USH2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains laminin EGF motifs, a pentaxin domain, and many fibronectin type III motifs. The protein is found in the basement membrane, and may be important in development and homeostasis of the inner ear and retina. Mutations within this gene have been associated with Usher syndrome type IIa and retinitis pigmentosa. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1eye photoreceptor cell development (GO:0042462)9.85919604
2protein-chromophore linkage (GO:0018298)8.65601622
3phototransduction, visible light (GO:0007603)8.62652938
4phototransduction (GO:0007602)8.53663226
5detection of visible light (GO:0009584)8.51661287
6detection of light stimulus (GO:0009583)8.35613460
7GMP metabolic process (GO:0046037)7.82635132
8* visual perception (GO:0007601)7.54829804
9* sensory perception of light stimulus (GO:0050953)7.48299774
10positive regulation of guanylate cyclase activity (GO:0031284)6.84776906
11cellular response to light stimulus (GO:0071482)6.27591585
12regulation of guanylate cyclase activity (GO:0031282)6.14040357
13photoreceptor cell differentiation (GO:0046530)6.11633020
14eye photoreceptor cell differentiation (GO:0001754)6.11633020
15drug catabolic process (GO:0042737)6.03280658
16detection of external stimulus (GO:0009581)5.90108980
17cellular ketone body metabolic process (GO:0046950)5.84896483
18regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.84348964
19retina development in camera-type eye (GO:0060041)5.83090704
20detection of abiotic stimulus (GO:0009582)5.78598394
21oxidative demethylation (GO:0070989)5.44611092
22exogenous drug catabolic process (GO:0042738)5.42554361
23epoxygenase P450 pathway (GO:0019373)5.34030198
24omega-hydroxylase P450 pathway (GO:0097267)5.31965194
25ketone body metabolic process (GO:1902224)5.25228126
26nonmotile primary cilium assembly (GO:0035058)4.95136983
27ethanol oxidation (GO:0006069)4.83373345
28L-phenylalanine catabolic process (GO:0006559)4.79525854
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.79525854
30aromatic amino acid family catabolic process (GO:0009074)4.72332389
31indole-containing compound catabolic process (GO:0042436)4.65938199
32indolalkylamine catabolic process (GO:0046218)4.65938199
33tryptophan catabolic process (GO:0006569)4.65938199
34regulation of cGMP metabolic process (GO:0030823)4.64212658
35cilium or flagellum-dependent cell motility (GO:0001539)4.55783174
36positive regulation of cGMP biosynthetic process (GO:0030828)4.52671833
37regulation of short-term neuronal synaptic plasticity (GO:0048172)4.50692043
38estrogen biosynthetic process (GO:0006703)4.41912727
39L-phenylalanine metabolic process (GO:0006558)4.28903581
40erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.28903581
41regulation of cGMP biosynthetic process (GO:0030826)4.22338669
42peptidyl-glutamic acid carboxylation (GO:0017187)4.19115332
43protein carboxylation (GO:0018214)4.19115332
44lactate metabolic process (GO:0006089)4.06284865
45adaptation of signaling pathway (GO:0023058)4.06280623
46positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.04525199
47synaptic vesicle docking involved in exocytosis (GO:0016081)4.03768397
48multicellular organism reproduction (GO:0032504)4.02719729
49bile acid biosynthetic process (GO:0006699)4.01744587
50acrosome reaction (GO:0007340)4.00980729
51cellular response to radiation (GO:0071478)3.99030626
52sperm motility (GO:0030317)3.98439358
53positive regulation of cGMP metabolic process (GO:0030825)3.92519465
54regulation of fibrinolysis (GO:0051917)3.88306557
55imidazole-containing compound metabolic process (GO:0052803)3.87823032
56drug metabolic process (GO:0017144)3.82534345
57glyoxylate metabolic process (GO:0046487)3.81520251
58regulation of acrosome reaction (GO:0060046)3.78091911
59regulation of protein activation cascade (GO:2000257)3.76432561
60sodium ion export (GO:0071436)3.73956217
61tryptophan metabolic process (GO:0006568)3.72901394
62ethanol metabolic process (GO:0006067)3.70888835
63* sensory perception (GO:0007600)3.70072846
64phenylpropanoid metabolic process (GO:0009698)3.68610603
65regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.67818376
66complement activation, alternative pathway (GO:0006957)3.66121269
67behavioral response to ethanol (GO:0048149)3.64915427
68regulation of complement activation (GO:0030449)3.64741027
69indolalkylamine metabolic process (GO:0006586)3.63420622
70detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.61736063
71response to pheromone (GO:0019236)3.60097334
72aromatic amino acid family metabolic process (GO:0009072)3.60049255
73regulation of clathrin-mediated endocytosis (GO:2000369)3.59112969
74kynurenine metabolic process (GO:0070189)3.55334989
75bile acid metabolic process (GO:0008206)3.51889955
76coenzyme catabolic process (GO:0009109)3.50582970
77regulation of voltage-gated calcium channel activity (GO:1901385)3.47986951
78alkaloid metabolic process (GO:0009820)3.46492911
79positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.45124474
80cellular potassium ion homeostasis (GO:0030007)3.40673255
81blood coagulation, intrinsic pathway (GO:0007597)3.37046889
82response to light stimulus (GO:0009416)3.34128436
83lipid translocation (GO:0034204)3.32254601
84phospholipid translocation (GO:0045332)3.32254601
85retina layer formation (GO:0010842)3.32129750
86chemosensory behavior (GO:0007635)3.31451080
87triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.30738820
88membrane hyperpolarization (GO:0060081)3.29812029
89receptor guanylyl cyclase signaling pathway (GO:0007168)3.29180197
90acylglycerol homeostasis (GO:0055090)3.24723571
91triglyceride homeostasis (GO:0070328)3.24723571
92innervation (GO:0060384)3.23677965
93serine family amino acid catabolic process (GO:0009071)3.23635231
94urea metabolic process (GO:0019627)3.22601182
95neuron development (GO:0048666)3.21861811
96cellular glucuronidation (GO:0052695)3.21318624
97regulation of synaptic vesicle exocytosis (GO:2000300)3.20376605
98cell morphogenesis involved in neuron differentiation (GO:0048667)3.20073122
99flavonoid metabolic process (GO:0009812)3.19020073
100positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.16425056
101peptidyl-glutamic acid modification (GO:0018200)3.15219391
102positive regulation of sodium ion transmembrane transport (GO:1902307)3.13833303
103axoneme assembly (GO:0035082)3.12836007
104positive regulation of neurotransmitter transport (GO:0051590)3.12781075
105negative regulation of protein activation cascade (GO:2000258)3.10474158
106spermatid development (GO:0007286)3.07490433
107regulation of female gonad development (GO:2000194)3.06570107
108negative regulation of complement activation (GO:0045916)3.06512003
109bile acid and bile salt transport (GO:0015721)3.06099790
110fusion of sperm to egg plasma membrane (GO:0007342)3.02908438
111uronic acid metabolic process (GO:0006063)2.98944919
112glucuronate metabolic process (GO:0019585)2.98944919
113cysteine metabolic process (GO:0006534)2.98360253
114protein localization to synapse (GO:0035418)2.97598955
115organic cation transport (GO:0015695)2.96607654
116peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.96000983
117tyrosine metabolic process (GO:0006570)2.95435838
118nephron tubule morphogenesis (GO:0072078)2.95255449
119nephron epithelium morphogenesis (GO:0072088)2.95255449
120indole-containing compound metabolic process (GO:0042430)2.93681238
121cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.92582991
122synaptic vesicle maturation (GO:0016188)2.92222191
123reproduction (GO:0000003)2.90286634
124negative regulation of cytosolic calcium ion concentration (GO:0051481)2.86073434
125cellular biogenic amine catabolic process (GO:0042402)2.85885874
126amine catabolic process (GO:0009310)2.85885874
127mitochondrion transport along microtubule (GO:0047497)2.84676307
128establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.84676307
129potassium ion homeostasis (GO:0055075)2.83545740
130piRNA metabolic process (GO:0034587)2.83042837
131calcium ion-dependent exocytosis (GO:0017156)2.82847730
132positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.82106470
133synaptic vesicle exocytosis (GO:0016079)2.81816598
134establishment of protein localization to Golgi (GO:0072600)2.81089353
135negative regulation of fibrinolysis (GO:0051918)2.80999008
136regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.80705993
137regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.80705993
138nitrogen cycle metabolic process (GO:0071941)2.80684297
139macroautophagy (GO:0016236)2.80633344
140benzene-containing compound metabolic process (GO:0042537)2.80468047
141amino-acid betaine metabolic process (GO:0006577)2.80449883
142phosphatidylethanolamine biosynthetic process (GO:0006646)2.80282284
143sulfation (GO:0051923)2.80129048
144dicarboxylic acid biosynthetic process (GO:0043650)2.80060312
145calcium ion import (GO:0070509)2.79995798
146detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.79228026
147regulation of triglyceride catabolic process (GO:0010896)2.78603188
148fibrinolysis (GO:0042730)2.78170654
149heme transport (GO:0015886)2.76334238
150righting reflex (GO:0060013)2.75993097
151regulation of synaptic vesicle transport (GO:1902803)2.75715897
152arginine metabolic process (GO:0006525)2.74125892
153xenobiotic catabolic process (GO:0042178)2.74087063
154NAD biosynthetic process (GO:0009435)2.71799484
155alpha-amino acid catabolic process (GO:1901606)2.69960079
156phosphate ion transmembrane transport (GO:0035435)2.69445352
157retinol metabolic process (GO:0042572)2.69192051
158protein K11-linked deubiquitination (GO:0035871)2.68750973
159epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.66961337
160xenobiotic metabolic process (GO:0006805)2.66364093
161urea cycle (GO:0000050)2.64091068
162retinoid metabolic process (GO:0001523)2.63698288
163behavioral response to nicotine (GO:0035095)2.63418018
164sperm-egg recognition (GO:0035036)2.63050874
165insulin secretion (GO:0030073)2.51288098
166regulation of penile erection (GO:0060405)2.50976644
167negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.49575039
168negative regulation of calcium ion transmembrane transport (GO:1903170)2.49575039
169diterpenoid metabolic process (GO:0016101)2.45538111
170potassium ion import (GO:0010107)2.41363324
171cerebellar Purkinje cell differentiation (GO:0021702)2.40271270
172establishment of mitochondrion localization (GO:0051654)2.40152975
173cellular potassium ion transport (GO:0071804)2.39525138
174potassium ion transmembrane transport (GO:0071805)2.39525138
175synaptic vesicle endocytosis (GO:0048488)2.39288282
176response to histamine (GO:0034776)2.36063302
177cell communication by electrical coupling (GO:0010644)2.34929810
178cellular sodium ion homeostasis (GO:0006883)2.34671803
179positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.32775636
180CDP-diacylglycerol biosynthetic process (GO:0016024)2.31871549
181detection of chemical stimulus involved in sensory perception (GO:0050907)2.30691317
182positive regulation of neurotransmitter secretion (GO:0001956)2.30387520
183prenylation (GO:0097354)2.28812092
184regulation of rhodopsin mediated signaling pathway (GO:0022400)14.3243075
185rhodopsin mediated signaling pathway (GO:0016056)14.0673774
186retinal cone cell development (GO:0046549)12.4152020
187detection of light stimulus involved in sensory perception (GO:0050962)11.0332977
188detection of light stimulus involved in visual perception (GO:0050908)11.0332977
189* photoreceptor cell maintenance (GO:0045494)10.5950202
190retinal rod cell development (GO:0046548)10.3852991
191photoreceptor cell development (GO:0042461)10.2494287

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.47969877
2EZH2_22144423_ChIP-Seq_EOC_Human4.20609154
3CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse2.89060168
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.77262172
5* GBX2_23144817_ChIP-Seq_PC3_Human2.53837710
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.41478740
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.36002074
8DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.31812947
9IGF1R_20145208_ChIP-Seq_DFB_Human2.27661372
10TAF15_26573619_Chip-Seq_HEK293_Human2.24736724
11* DROSHA_22980978_ChIP-Seq_HELA_Human2.23840191
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.22161902
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13922395
14REST_21632747_ChIP-Seq_MESCs_Mouse2.10169294
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.05580574
16* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.95069689
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89896992
18* ER_23166858_ChIP-Seq_MCF-7_Human1.89676438
19FUS_26573619_Chip-Seq_HEK293_Human1.85541052
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84594930
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79757491
22UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.77302352
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.72046915
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70149704
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70061363
26* SMAD4_21799915_ChIP-Seq_A2780_Human1.67866942
27SMAD3_21741376_ChIP-Seq_HESCs_Human1.64379599
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62216573
29LXR_22158963_ChIP-Seq_LIVER_Mouse1.60768732
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.60244983
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59249994
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57980684
33AR_21572438_ChIP-Seq_LNCaP_Human1.57093906
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56682398
35* STAT3_23295773_ChIP-Seq_U87_Human1.56127869
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.55551159
37TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.55451159
38ZNF274_21170338_ChIP-Seq_K562_Hela1.53841239
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53055180
40* AR_19668381_ChIP-Seq_PC3_Human1.53005626
41P53_22127205_ChIP-Seq_FIBROBLAST_Human1.52216410
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.50023262
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.47567827
44VDR_22108803_ChIP-Seq_LS180_Human1.46238957
45* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43424654
46* SMAD3_21741376_ChIP-Seq_EPCs_Human1.43155150
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43067834
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.40977424
49RARB_27405468_Chip-Seq_BRAIN_Mouse1.40817188
50* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39588978
51SMAD4_21741376_ChIP-Seq_EPCs_Human1.37557279
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.37455278
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36727451
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36219054
55WDR5_24793694_ChIP-Seq_LNCAP_Human1.32910893
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.31502916
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31429143
58RXR_22158963_ChIP-Seq_LIVER_Mouse1.31211424
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31160396
60EWS_26573619_Chip-Seq_HEK293_Human1.27806442
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.26968948
62HTT_18923047_ChIP-ChIP_STHdh_Human1.26558887
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25224341
64SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24412470
65* TCF4_23295773_ChIP-Seq_U87_Human1.24221771
66BCAT_22108803_ChIP-Seq_LS180_Human1.23911239
67* RUNX2_22187159_ChIP-Seq_PCA_Human1.23500259
68YAP1_20516196_ChIP-Seq_MESCs_Mouse1.22203719
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20929630
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.20691153
71* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20043865
72* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19411803
73TP53_18474530_ChIP-ChIP_U2OS_Human1.18913987
74* TBL1_22424771_ChIP-Seq_293T_Human1.18705700
75* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18410858
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.17630747
77TCF4_22108803_ChIP-Seq_LS180_Human1.16468990
78CBP_21632823_ChIP-Seq_H3396_Human1.16243688
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.16095711
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15398042
81* NANOG_18555785_Chip-Seq_ESCs_Mouse1.15055543
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14807361
83* CDX2_22108803_ChIP-Seq_LS180_Human1.14140910
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13298921
85* NFYB_21822215_ChIP-Seq_K562_Human1.13195404
86* EZH2_27294783_Chip-Seq_NPCs_Mouse1.13108570
87DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12901973
88* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12778591
89BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12624722
90KDM2B_26808549_Chip-Seq_K562_Human1.12623191
91EP300_21415370_ChIP-Seq_HL-1_Mouse1.12495789
92TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12181899
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12042766
94ISL1_27105846_Chip-Seq_CPCs_Mouse1.11989993
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.11879657
96SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11146992
97PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10018851
98MYC_19829295_ChIP-Seq_ESCs_Human1.09636037
99* PHF8_20622853_ChIP-Seq_HELA_Human1.09443606
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09333966
101FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.09168629
102* ETV1_20927104_ChIP-Seq_GIST48_Human1.09072570
103* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08298396
104* P300_19829295_ChIP-Seq_ESCs_Human1.07978142
105* NFE2_27457419_Chip-Seq_LIVER_Mouse1.07965715
106ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07616999
107FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07506604
108FOXA1_25329375_ChIP-Seq_VCAP_Human1.07506604
109AR_25329375_ChIP-Seq_VCAP_Human1.07058972
110SMAD4_21741376_ChIP-Seq_HESCs_Human1.06851383
111FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06831790
112* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.06759102
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06501815
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06397595
115GATA3_21878914_ChIP-Seq_MCF-7_Human1.06206674
116* SOX2_19829295_ChIP-Seq_ESCs_Human1.06039974
117* NANOG_19829295_ChIP-Seq_ESCs_Human1.06039974
118GF1_26923725_Chip-Seq_HPCs_Mouse1.05963413
119PRDM14_20953172_ChIP-Seq_ESCs_Human1.05887869
120NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.05592213
121AR_20517297_ChIP-Seq_VCAP_Human1.04552975
122SMAD3_21741376_ChIP-Seq_ESCs_Human1.04486946
123CBX2_27304074_Chip-Seq_ESCs_Mouse1.04309064
124* CJUN_26792858_Chip-Seq_BT549_Human1.04256547
125CTCF_27219007_Chip-Seq_Bcells_Human1.04109410
126NCOR_22424771_ChIP-Seq_293T_Human1.03789927
127SOX2_21211035_ChIP-Seq_LN229_Gbm1.03641607
128* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.03183864
129CBP_20019798_ChIP-Seq_JUKART_Human1.03151601
130IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03151601
131* HNFA_21074721_ChIP-Seq_CACO-2_Human1.03065076
132* NFYA_21822215_ChIP-Seq_K562_Human1.02928023
133RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02479037
134ERG_20517297_ChIP-Seq_VCAP_Human1.02462955
135LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01978881
136* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01191407
137AHR_22903824_ChIP-Seq_MCF-7_Human1.00984031
138ELK4_26923725_Chip-Seq_MESODERM_Mouse1.00804386
139RING1B_27294783_Chip-Seq_NPCs_Mouse1.00540158
140VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00480443
141WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00400318
142KDM2B_26808549_Chip-Seq_REH_Human1.00113909
143OCT4_20526341_ChIP-Seq_ESCs_Human0.99883726
144POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99792259
145TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99792259
146TAF2_19829295_ChIP-Seq_ESCs_Human0.99766572
147RXR_22108803_ChIP-Seq_LS180_Human0.99762888
148ARNT_22903824_ChIP-Seq_MCF-7_Human0.99659188
149* OCT1_27270436_Chip-Seq_PROSTATE_Human0.99657529
150EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98389275
151RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98389275
152ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97866657
153GF1B_26923725_Chip-Seq_HPCs_Mouse0.96368100
154* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95353198
155FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92987745
156STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92146407
157JARID2_20064375_ChIP-Seq_MESCs_Mouse0.92103841
158TAL1_26923725_Chip-Seq_HPCs_Mouse0.89831858
159SMC4_20622854_ChIP-Seq_HELA_Human0.89511269

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog8.85745851
2MP0006072_abnormal_retinal_apoptosis6.75260775
3MP0005253_abnormal_eye_physiology6.53331113
4MP0002139_abnormal_hepatobiliary_system6.00555471
5MP0005085_abnormal_gallbladder_physiolo4.00834952
6MP0003195_calcinosis3.91239805
7MP0003950_abnormal_plasma_membrane3.70708160
8* MP0005195_abnormal_posterior_eye3.47123652
9MP0002138_abnormal_hepatobiliary_system3.40353888
10MP0002090_abnormal_vision3.29546786
11MP0005360_urolithiasis3.26861404
12MP0001324_abnormal_eye_pigmentation3.17565103
13MP0008875_abnormal_xenobiotic_pharmacok3.10148949
14MP0002638_abnormal_pupillary_reflex3.08349673
15MP0005391_vision/eye_phenotype3.07984373
16* MP0002229_neurodegeneration2.45710364
17MP0003878_abnormal_ear_physiology2.43412432
18MP0005377_hearing/vestibular/ear_phenot2.43412432
19MP0003136_yellow_coat_color2.36981207
20MP0003718_maternal_effect2.34597788
21MP0005423_abnormal_somatic_nervous2.04886110
22MP0003011_delayed_dark_adaptation10.3198160
23MP0001986_abnormal_taste_sensitivity1.95613787
24MP0010329_abnormal_lipoprotein_level1.89842206
25MP0002653_abnormal_ependyma_morphology1.86428024
26MP0005332_abnormal_amino_acid1.78646816
27* MP0002752_abnormal_somatic_nervous1.73822982
28MP0004233_abnormal_muscle_weight1.73631068
29MP0005174_abnormal_tail_pigmentation1.70209090
30MP0001502_abnormal_circadian_rhythm1.62728663
31MP0001984_abnormal_olfaction1.61590408
32MP0001666_abnormal_nutrient_absorption1.55641517
33MP0005171_absent_coat_pigmentation1.41802940
34MP0005395_other_phenotype1.39311447
35MP0005647_abnormal_sex_gland1.39288388
36MP0001501_abnormal_sleep_pattern1.39090143
37MP0001764_abnormal_homeostasis1.38651731
38MP0005248_abnormal_Harderian_gland1.37408640
39MP0008057_abnormal_DNA_replication1.37060334
40MP0008877_abnormal_DNA_methylation1.34700466
41MP0002837_dystrophic_cardiac_calcinosis1.33767030
42MP0009697_abnormal_copulation1.30436608
43* MP0002882_abnormal_neuron_morphology1.26707315
44MP0002876_abnormal_thyroid_physiology1.26390191
45MP0002822_catalepsy1.25365108
46MP0004019_abnormal_vitamin_homeostasis1.24010900
47MP0005379_endocrine/exocrine_gland_phen1.23134560
48MP0010234_abnormal_vibrissa_follicle1.22616718
49MP0006292_abnormal_olfactory_placode1.22386193
50MP0004043_abnormal_pH_regulation1.16322608
51MP0010386_abnormal_urinary_bladder1.15207828
52MP0002118_abnormal_lipid_homeostasis1.08412016
53MP0002163_abnormal_gland_morphology1.06019721
54MP0008872_abnormal_physiological_respon1.05432047
55MP0001756_abnormal_urination1.04981004
56MP0004782_abnormal_surfactant_physiolog1.01112039
57MP0004270_analgesia1.00811269
58MP0001486_abnormal_startle_reflex1.00590635
59MP0003646_muscle_fatigue1.00578048
60MP0000427_abnormal_hair_cycle0.98920202
61MP0001485_abnormal_pinna_reflex0.97322527
62MP0010368_abnormal_lymphatic_system0.97102586
63MP0005084_abnormal_gallbladder_morpholo0.97056929
64MP0009780_abnormal_chondrocyte_physiolo0.93249914
65MP0001346_abnormal_lacrimal_gland0.92197410
66MP0002735_abnormal_chemical_nociception0.92177281
67MP0002160_abnormal_reproductive_system0.91396936
68MP0006276_abnormal_autonomic_nervous0.91232559
69MP0004885_abnormal_endolymph0.88584818
70MP0000538_abnormal_urinary_bladder0.88036988
71MP0002332_abnormal_exercise_endurance0.86562203
72MP0002161_abnormal_fertility/fecundity0.83950782
73MP0001968_abnormal_touch/_nociception0.82645375
74MP0001664_abnormal_digestion0.81574287
75MP0002693_abnormal_pancreas_physiology0.81062872
76MP0002909_abnormal_adrenal_gland0.80925071
77MP0005083_abnormal_biliary_tract0.80403730
78MP0000013_abnormal_adipose_tissue0.79989313
79MP0003806_abnormal_nucleotide_metabolis0.79872021
80MP0004130_abnormal_muscle_cell0.79463155
81MP0001944_abnormal_pancreas_morphology0.79459875
82MP0005499_abnormal_olfactory_system0.78938206
83MP0005394_taste/olfaction_phenotype0.78938206
84MP0002127_abnormal_cardiovascular_syste0.77477196
85MP0002734_abnormal_mechanical_nocicepti0.77213890
86MP0002877_abnormal_melanocyte_morpholog0.75286333
87MP0003045_fibrosis0.73851708
88MP0004142_abnormal_muscle_tone0.73634879
89MP0000569_abnormal_digit_pigmentation0.72396664
90MP0005187_abnormal_penis_morphology0.72262315
91MP0002210_abnormal_sex_determination0.70655459
92MP0002272_abnormal_nervous_system0.70554011
93MP0005645_abnormal_hypothalamus_physiol0.70445903
94MP0002168_other_aberrant_phenotype0.70385051
95MP0003634_abnormal_glial_cell0.70007464
96MP0000631_abnormal_neuroendocrine_gland0.68723150
97MP0003879_abnormal_hair_cell0.68283285
98MP0003283_abnormal_digestive_organ0.65950018
99MP0000653_abnormal_sex_gland0.65741999
100MP0008789_abnormal_olfactory_epithelium0.65539579
101MP0005266_abnormal_metabolism0.65414748
102MP0005197_abnormal_uvea_morphology0.63684109
103MP0004145_abnormal_muscle_electrophysio0.62260082
104MP0005220_abnormal_exocrine_pancreas0.61997680
105MP0002234_abnormal_pharynx_morphology0.59323027
106MP0003635_abnormal_synaptic_transmissio0.55729173
107MP0003890_abnormal_embryonic-extraembry0.55517482
108MP0004215_abnormal_myocardial_fiber0.54308882
109MP0002064_seizures0.53460811
110MP0002928_abnormal_bile_duct0.52607851
111MP0002067_abnormal_sensory_capabilities0.51844782
112MP0002078_abnormal_glucose_homeostasis0.50520714
113MP0004036_abnormal_muscle_relaxation0.50294794
114* MP0001963_abnormal_hearing_physiology0.49264784
115MP0000678_abnormal_parathyroid_gland0.48892509
116MP0005646_abnormal_pituitary_gland0.45690035
117MP0002063_abnormal_learning/memory/cond0.44805850
118MP0003183_abnormal_peptide_metabolism0.44215738
119MP0001286_abnormal_eye_development0.43856082
120MP0001661_extended_life_span0.43466430
121MP0003698_abnormal_male_reproductive0.42124123
122MP0009046_muscle_twitch0.40750755
123MP0008775_abnormal_heart_ventricle0.40123522
124MP0004084_abnormal_cardiac_muscle0.39456865
125MP0002572_abnormal_emotion/affect_behav0.38094759
126MP0010030_abnormal_orbit_morphology0.37240223
127MP0003868_abnormal_feces_composition0.36509685
128MP0004742_abnormal_vestibular_system0.36434882
129MP0005365_abnormal_bile_salt0.35535576
130MP0004085_abnormal_heartbeat0.35187441
131MP0005386_behavior/neurological_phenoty0.34891327
132MP0004924_abnormal_behavior0.34891327
133MP0003252_abnormal_bile_duct0.31885090
134MP0000003_abnormal_adipose_tissue0.31560380
135MP0002184_abnormal_innervation0.29958961
136MP0002102_abnormal_ear_morphology0.29817364
137MP0005410_abnormal_fertilization0.29687098
138MP0000462_abnormal_digestive_system0.29212950
139MP0003953_abnormal_hormone_level0.28947734
140MP0005620_abnormal_muscle_contractility0.28508416
141MP0009745_abnormal_behavioral_response0.26146500
142* MP0000026_abnormal_inner_ear0.25545170
143MP0002152_abnormal_brain_morphology0.25340237
144MP0005670_abnormal_white_adipose0.25248667
145MP0002697_abnormal_eye_size0.25155830
146MP0003633_abnormal_nervous_system0.24790685
147MP0005257_abnormal_intraocular_pressure0.24768423
148MP0001929_abnormal_gametogenesis0.24611767
149MP0005376_homeostasis/metabolism_phenot0.24278291
150MP0005595_abnormal_vascular_smooth0.23957095
151MP0002108_abnormal_muscle_morphology0.23940708
152MP0000230_abnormal_systemic_arterial0.23909097

Predicted human phenotypes

RankGene SetZ-score
1Abnormal rod and cone electroretinograms (HP:0008323)9.93457405
2Absent rod-and cone-mediated responses on ERG (HP:0007688)9.78637335
3Central scotoma (HP:0000603)9.36497853
4Abnormality of macular pigmentation (HP:0008002)8.33988645
5Scotoma (HP:0000575)8.11131584
6Dyschromatopsia (HP:0007641)7.74948142
7Pigmentary retinal degeneration (HP:0001146)7.25654908
8Chorioretinal atrophy (HP:0000533)7.10474880
9Pendular nystagmus (HP:0012043)6.89112600
10Decreased central vision (HP:0007663)6.69267834
11* Attenuation of retinal blood vessels (HP:0007843)6.68567175
12Abolished electroretinogram (ERG) (HP:0000550)6.39981585
13Severe visual impairment (HP:0001141)5.66545863
14Prolonged partial thromboplastin time (HP:0003645)5.66100645
15* Type II diabetes mellitus (HP:0005978)5.31831642
16* Photophobia (HP:0000613)5.17895271
17Cone-rod dystrophy (HP:0000548)4.85267205
18Macular degeneration (HP:0000608)4.72669237
19Posterior subcapsular cataract (HP:0007787)4.71415295
20Abnormality of monocarboxylic acid metabolism (HP:0010996)4.61100586
21Constricted visual fields (HP:0001133)4.42244997
22Keratoconus (HP:0000563)4.35832839
23Increased corneal curvature (HP:0100692)4.35832839
24Abnormality of aromatic amino acid family metabolism (HP:0004338)4.27878901
25* Retinitis pigmentosa (HP:0000510)3.96884002
26Vitreoretinal degeneration (HP:0000655)3.87294758
27Choroideremia (HP:0001139)3.83728286
28Hypophosphatemic rickets (HP:0004912)3.50824269
29Joint hemorrhage (HP:0005261)3.48952100
30Progressive visual loss (HP:0000529)3.34871325
31Complement deficiency (HP:0004431)3.34716726
32Hyperlipoproteinemia (HP:0010980)3.12307617
33Generalized aminoaciduria (HP:0002909)3.10275476
34Deep venous thrombosis (HP:0002625)3.07892213
35Decreased electroretinogram (ERG) amplitude (HP:0000654)3.07595410
36Intrahepatic cholestasis (HP:0001406)3.00212963
37Hypobetalipoproteinemia (HP:0003563)2.94165053
38Subcapsular cataract (HP:0000523)2.94066012
39Retinal atrophy (HP:0001105)2.91574143
40Abnormality of the intrinsic pathway (HP:0010989)2.86396722
41Fair hair (HP:0002286)2.80555003
42Azoospermia (HP:0000027)2.67778151
43Abnormality of pyrimidine metabolism (HP:0004353)2.66149592
44Hypoalphalipoproteinemia (HP:0003233)2.65686882
45Xanthomatosis (HP:0000991)2.65371672
46Tubulointerstitial nephritis (HP:0001970)2.62029596
47Hypolipoproteinemia (HP:0010981)2.59009423
48Gait imbalance (HP:0002141)2.58465709
49Congenital primary aphakia (HP:0007707)2.54023541
50Abnormality of urine glucose concentration (HP:0011016)2.53376380
51Glycosuria (HP:0003076)2.53376380
52Abnormality of glutamine family amino acid metabolism (HP:0010902)2.43894387
53Ileus (HP:0002595)2.40702294
54Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.38901109
55Rickets (HP:0002748)2.34947480
56Medial flaring of the eyebrow (HP:0010747)2.32990515
57Intestinal atresia (HP:0011100)2.31950726
58Abnormality of the renal cortex (HP:0011035)2.30848426
59Male infertility (HP:0003251)2.27861496
60Conjugated hyperbilirubinemia (HP:0002908)2.27469547
61Gaze-evoked nystagmus (HP:0000640)2.24935102
62Abnormality of complement system (HP:0005339)2.24637888
63Dynein arm defect of respiratory motile cilia (HP:0012255)2.24521216
64Absent/shortened dynein arms (HP:0200106)2.24521216
65Abnormal ciliary motility (HP:0012262)2.23583662
66Nephrogenic diabetes insipidus (HP:0009806)2.21941981
67* Wide nasal bridge (HP:0000431)2.20525335
68Proximal tubulopathy (HP:0000114)2.18215640
69Aplasia/Hypoplasia of the fovea (HP:0008060)2.13638335
70Hypoplasia of the fovea (HP:0007750)2.13638335
71Abnormality of alanine metabolism (HP:0010916)2.13027598
72Hyperalaninemia (HP:0003348)2.13027598
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13027598
74Abnormality of the renal medulla (HP:0100957)2.12785964
75Pancreatic fibrosis (HP:0100732)2.07681419
76Infertility (HP:0000789)2.07386431
77Abnormality of the common coagulation pathway (HP:0010990)2.06894455
78Generalized hypopigmentation of hair (HP:0011358)2.04673895
79Optic disc pallor (HP:0000543)2.01315749
80Abnormality of the fovea (HP:0000493)2.01223560
81Congenital stationary night blindness (HP:0007642)14.1706203
82* Bony spicule pigmentary retinopathy (HP:0007737)10.4238733
83Supernumerary spleens (HP:0009799)1.99596929
84Tubular atrophy (HP:0000092)1.99431172
85Polydipsia (HP:0001959)1.99092893
86Abnormal drinking behavior (HP:0030082)1.99092893
87Poikiloderma (HP:0001029)1.98824060
88Hyperkalemia (HP:0002153)1.96020056
89Ketosis (HP:0001946)1.94405187
90Poor coordination (HP:0002370)1.94003676
91Aplasia/Hypoplasia of the tibia (HP:0005772)1.93078496
92True hermaphroditism (HP:0010459)1.91645781
93Abnormality of the hepatic vasculature (HP:0006707)1.89734190
94Abnormal spermatogenesis (HP:0008669)1.88655235
95Cystic liver disease (HP:0006706)1.86136897
96Facial diplegia (HP:0001349)1.85611700
97Vascular calcification (HP:0004934)1.84660436
98Abnormality of vitamin metabolism (HP:0100508)1.83115117
99Facial shape deformation (HP:0011334)1.82802360
100Potter facies (HP:0002009)1.82802360
101Abnormality of sulfur amino acid metabolism (HP:0004339)1.82736839
102Annular pancreas (HP:0001734)1.80748262
103Abnormality of chloride homeostasis (HP:0011422)1.80415717
104Spontaneous abortion (HP:0005268)1.77832184
105Enlarged epiphyses (HP:0010580)1.76657649
106Vaginal atresia (HP:0000148)1.76654948
107Genital tract atresia (HP:0001827)1.74996277
108Bile duct proliferation (HP:0001408)1.74066011
109Abnormal biliary tract physiology (HP:0012439)1.74066011
110Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.66429371
111Aplasia/Hypoplasia of the lens (HP:0008063)1.64316584
112Pancreatic cysts (HP:0001737)1.62615119
113Hyperinsulinemic hypoglycemia (HP:0000825)1.59796945
114* Optic atrophy (HP:0000648)1.53649958
115Aplasia/Hypoplasia of the macula (HP:0008059)1.53086583
116Polar cataract (HP:0010696)1.51030341
117Aplasia/Hypoplasia of the tongue (HP:0010295)1.47185202
118Molar tooth sign on MRI (HP:0002419)1.46304869
119Abnormality of midbrain morphology (HP:0002418)1.46304869
120Horizontal nystagmus (HP:0000666)1.44828408
121* Congenital sensorineural hearing impairment (HP:0008527)1.43088509
122Severe Myopia (HP:0011003)1.42421326
123Epileptic encephalopathy (HP:0200134)1.41560445
124Aplasia/Hypoplasia affecting the retina (HP:0008061)1.41116415
125Hypoglycemic seizures (HP:0002173)1.40798142
126Dysdiadochokinesis (HP:0002075)1.40611899
127Astigmatism (HP:0000483)1.31768628
128Pancreatic islet-cell hyperplasia (HP:0004510)1.27658467
129Abnormality of endocrine pancreas physiology (HP:0012093)1.25135166
130Abnormality of the pancreatic islet cells (HP:0006476)1.25135166
131Visual hallucinations (HP:0002367)1.21246638
132Insulin-resistant diabetes mellitus (HP:0000831)1.19735215
133Febrile seizures (HP:0002373)1.19236348
134Chorioretinal coloboma (HP:0000567)1.18097482
135Hyperglycemia (HP:0003074)1.17597123
136Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.17328870
137Abnormality of the parathyroid morphology (HP:0011766)1.14557330
138Progressive cerebellar ataxia (HP:0002073)1.12319302
139Septo-optic dysplasia (HP:0100842)1.12119195
140Truncal ataxia (HP:0002078)1.11556873
141Left ventricular hypertrophy (HP:0001712)1.11381690
142Increased neuronal autofluorescent lipopigment (HP:0002074)1.11369926
143Furrowed tongue (HP:0000221)1.11030876
144Sclerocornea (HP:0000647)1.09224763
145Symptomatic seizures (HP:0011145)1.06842762
146Retinal detachment (HP:0000541)1.04658093
147Macroorchidism (HP:0000053)1.04644756
148Decreased circulating renin level (HP:0003351)1.02717974
149Broad foot (HP:0001769)1.00979833
150Increased cerebral lipofuscin (HP:0011813)0.97696884
151Osteomalacia (HP:0002749)0.97426625
152Large for gestational age (HP:0001520)0.97326481
153Nephronophthisis (HP:0000090)0.96859605
154Genetic anticipation (HP:0003743)0.96585656
155Interstitial pulmonary disease (HP:0006530)0.96494919
156Asthma (HP:0002099)0.96446587
157Specific learning disability (HP:0001328)0.95741996
158Depression (HP:0000716)0.95185899
159Hypermetropia (HP:0000540)0.94198997
160Congenital hepatic fibrosis (HP:0002612)0.93174372
161Chronic hepatic failure (HP:0100626)0.93051362
162Postaxial hand polydactyly (HP:0001162)0.92118662
163Abnormality of the fingertips (HP:0001211)0.91982005
164Decreased testicular size (HP:0008734)0.91547423

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK18.35029012
2INSRR4.46835599
3TAOK33.31667443
4IRAK23.18058488
5MUSK2.98799913
6LMTK22.84834493
7MAP4K22.80086277
8PINK12.71701239
9PBK2.60585943
10ACVR1B2.36914718
11STK382.34911492
12FRK2.33181768
13PRKD32.18492130
14HIPK22.11163952
15ZAK2.07034994
16LATS11.79752514
17PLK41.69568213
18PIK3CG1.64338978
19STK391.61150518
20ADRBK21.59138808
21CAMK1G1.56921075
22DYRK1A1.56660136
23MAP3K41.54121029
24PAK61.48587807
25TLK11.42286360
26CAMK1D1.38221481
27PASK1.36120129
28EPHA31.32713874
29FER1.31086427
30CDK121.29435515
31STK31.28434391
32SGK4941.18404969
33SGK2231.18404969
34BRD41.17211984
35MAP3K101.17009635
36PRKAA11.15823066
37MARK11.14341348
38AKT31.08599236
39PIK3CA1.07103020
40OBSCN1.05686994
41ADRBK11.05560796
42MAP3K21.04403819
43DYRK1B1.04213174
44OXSR11.03303802
45ICK1.02344094
46SGK21.00842360
47PRKG21.00632193
48PAK30.99746904
49IRAK10.99163474
50MAP2K70.99012718
51PRKCH0.96581232
52CDK30.95523020
53CAMK2D0.95024234
54MAP3K60.94909377
55CDK90.94598403
56NEK60.88753663
57CSNK1D0.86969446
58WNK40.86295148
59PRKAA20.85240035
60PRKD20.85075070
61WNK10.83143173
62NLK0.79377852
63MAPK70.78821241
64PHKG20.78770914
65PHKG10.78770914
66MAP3K10.77942764
67CDC42BPA0.77599406
68RPS6KA40.76609561
69KSR20.73543761
70TNIK0.73326723
71SGK30.70578700
72DDR20.70192781
73NTRK30.68893384
74CAMKK10.67807200
75ERBB20.67523937
76PRPF4B0.67503036
77MET0.67302408
78TTK0.66981445
79NUAK10.65067701
80PRKCB0.64318248
81NEK20.63623696
82STK38L0.63330060
83MAPK120.63254100
84GSK3B0.62251292
85PTK2B0.61408481
86RPS6KA30.60341932
87PRKCZ0.59643935
88SIK20.58273687
89TIE10.58058854
90WNK30.57945749
91STK240.57508452
92TGFBR10.57098679
93PDPK10.56585805
94MAPK100.56191602
95PNCK0.55852105
96STK110.55702574
97BRSK20.55444187
98SGK10.55209983
99PLK20.54983524
100MAPK140.53950906
101MARK20.53479143
102TRPM70.53320738
103PRKACG0.52946582
104NEK10.51878248
105PDK10.51516242
106CDK50.50703537
107MARK30.50447093
108DAPK20.48355575
109PRKDC0.47479574
110MST1R0.47319787
111ATM0.45890958
112MAPK150.45337332
113FGFR20.44524454
114MTOR0.43724955
115MAPK90.43412991
116CDK10.43335964
117CHEK20.42976550
118PLK30.42804755
119PRKACB0.41899513
120BLK0.41207386
121PRKACA0.40290338
122MAP3K90.40043337
123MYLK0.39224911
124RET0.38842968
125SIK10.38804594
126TNK20.38556101
127ARAF0.37644269
128MAPK110.37517332
129MAP2K40.36991898
130PRKCQ0.36302426
131CAMK10.36132756
132MAP3K70.35274888
133CSNK1G10.35214852
134PRKCE0.34948550
135PRKG10.34945404
136RPS6KB10.34517722
137PRKCG0.33914219
138PKN10.33177372
139BMPR1B0.33084472
140JAK10.32842677
141CAMK2A0.32402738
142MAP2K10.32037629
143PRKCA0.31920322
144GRK50.31575480
145MAPK10.31381309
146MKNK20.31015601
147AURKA0.30062522
148RPS6KA50.26341279
149ROCK10.23692836
150TXK0.23137822
151MELK0.22791944

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.65355030
2Caffeine metabolism_Homo sapiens_hsa002323.29662613
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.00085091
4Butanoate metabolism_Homo sapiens_hsa006502.70918117
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.60352477
6Chemical carcinogenesis_Homo sapiens_hsa052042.56711633
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.52450765
8Steroid hormone biosynthesis_Homo sapiens_hsa001402.48716988
9Complement and coagulation cascades_Homo sapiens_hsa046102.47862790
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.45321420
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.30921912
12Arginine biosynthesis_Homo sapiens_hsa002202.28591214
13Fatty acid degradation_Homo sapiens_hsa000712.20425898
14Synaptic vesicle cycle_Homo sapiens_hsa047212.12789752
15Tryptophan metabolism_Homo sapiens_hsa003802.04106434
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.01697126
17Phototransduction_Homo sapiens_hsa0474414.0746460
18Histidine metabolism_Homo sapiens_hsa003401.88162668
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.80933034
20Circadian rhythm_Homo sapiens_hsa047101.77722137
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.75844452
22Tyrosine metabolism_Homo sapiens_hsa003501.74966733
23Insulin secretion_Homo sapiens_hsa049111.67409587
24GABAergic synapse_Homo sapiens_hsa047271.61788886
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59916912
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57482305
27Phenylalanine metabolism_Homo sapiens_hsa003601.52896821
28Olfactory transduction_Homo sapiens_hsa047401.52701673
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.49917996
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29728545
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27534446
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26065969
33Peroxisome_Homo sapiens_hsa041461.25442704
34Fatty acid biosynthesis_Homo sapiens_hsa000611.24767985
35PPAR signaling pathway_Homo sapiens_hsa033201.24045692
36Sulfur relay system_Homo sapiens_hsa041221.23655693
37Arachidonic acid metabolism_Homo sapiens_hsa005901.23363728
38beta-Alanine metabolism_Homo sapiens_hsa004101.22067208
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.21895939
40Morphine addiction_Homo sapiens_hsa050321.18344472
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16133082
42Cholinergic synapse_Homo sapiens_hsa047251.14124250
43ABC transporters_Homo sapiens_hsa020101.12293251
44Circadian entrainment_Homo sapiens_hsa047131.10270110
45Type II diabetes mellitus_Homo sapiens_hsa049301.07787489
46Selenocompound metabolism_Homo sapiens_hsa004501.06449852
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02009652
48Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00860479
49Retinol metabolism_Homo sapiens_hsa008300.98911702
50Nicotine addiction_Homo sapiens_hsa050330.96185852
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92892872
52Dopaminergic synapse_Homo sapiens_hsa047280.92798651
53Propanoate metabolism_Homo sapiens_hsa006400.92443519
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92049926
55Starch and sucrose metabolism_Homo sapiens_hsa005000.91510109
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.90013328
57Glutamatergic synapse_Homo sapiens_hsa047240.88098598
58Fatty acid metabolism_Homo sapiens_hsa012120.87472516
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87154671
60Fructose and mannose metabolism_Homo sapiens_hsa000510.86823893
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86786177
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84909003
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83868112
64Serotonergic synapse_Homo sapiens_hsa047260.82990198
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77218054
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73972831
67Pyruvate metabolism_Homo sapiens_hsa006200.73624268
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73577604
69Inositol phosphate metabolism_Homo sapiens_hsa005620.71705555
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.71530950
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70145395
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69548724
73Renin secretion_Homo sapiens_hsa049240.67624160
74Fat digestion and absorption_Homo sapiens_hsa049750.65821171
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65088753
76Oxytocin signaling pathway_Homo sapiens_hsa049210.63527250
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63289423
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60929815
79Sulfur metabolism_Homo sapiens_hsa009200.60531814
80Arginine and proline metabolism_Homo sapiens_hsa003300.60093268
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58759087
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57878029
83Dilated cardiomyopathy_Homo sapiens_hsa054140.57675265
84One carbon pool by folate_Homo sapiens_hsa006700.57648642
85Glucagon signaling pathway_Homo sapiens_hsa049220.57352865
86Cocaine addiction_Homo sapiens_hsa050300.54510106
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52383536
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52000687
89Salivary secretion_Homo sapiens_hsa049700.51748050
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.51666161
91cAMP signaling pathway_Homo sapiens_hsa040240.51583457
92Metabolic pathways_Homo sapiens_hsa011000.51243074
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50957619
94Cardiac muscle contraction_Homo sapiens_hsa042600.50305663
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49486457
96Mineral absorption_Homo sapiens_hsa049780.49136669
97mTOR signaling pathway_Homo sapiens_hsa041500.48225142
98Amphetamine addiction_Homo sapiens_hsa050310.47478665
99Basal transcription factors_Homo sapiens_hsa030220.46865021
100Galactose metabolism_Homo sapiens_hsa000520.46486012
101Ether lipid metabolism_Homo sapiens_hsa005650.46109334
102Vitamin B6 metabolism_Homo sapiens_hsa007500.45571827
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45227428
104Taste transduction_Homo sapiens_hsa047420.44861948
105Vibrio cholerae infection_Homo sapiens_hsa051100.43923229
106Pancreatic secretion_Homo sapiens_hsa049720.38630510
107Lysine degradation_Homo sapiens_hsa003100.38563447
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38118247
109Long-term potentiation_Homo sapiens_hsa047200.37229508
110Protein export_Homo sapiens_hsa030600.36213577
111AMPK signaling pathway_Homo sapiens_hsa041520.35099030
112Thyroid hormone synthesis_Homo sapiens_hsa049180.34805220
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.34652745
114Vitamin digestion and absorption_Homo sapiens_hsa049770.34341230
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.33992493
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32762330
117Purine metabolism_Homo sapiens_hsa002300.32253597
118N-Glycan biosynthesis_Homo sapiens_hsa005100.31933334
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30563906
120Gastric acid secretion_Homo sapiens_hsa049710.29433776
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29394621
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28827198
123Insulin resistance_Homo sapiens_hsa049310.27899076
124Glycerolipid metabolism_Homo sapiens_hsa005610.27251029
125Renal cell carcinoma_Homo sapiens_hsa052110.27187725
126Collecting duct acid secretion_Homo sapiens_hsa049660.27027599
127Systemic lupus erythematosus_Homo sapiens_hsa053220.26888167
128Calcium signaling pathway_Homo sapiens_hsa040200.25897852
129Glutathione metabolism_Homo sapiens_hsa004800.25127889
130GnRH signaling pathway_Homo sapiens_hsa049120.23735163
131Bile secretion_Homo sapiens_hsa049760.23612164
132Nitrogen metabolism_Homo sapiens_hsa009100.23348418
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.23146744
134Alcoholism_Homo sapiens_hsa050340.22791081
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22268325
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21956081
137Ovarian steroidogenesis_Homo sapiens_hsa049130.20906874
138Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19124270
139Type I diabetes mellitus_Homo sapiens_hsa049400.17804814
140MAPK signaling pathway_Homo sapiens_hsa040100.17399958
141Lysosome_Homo sapiens_hsa041420.17311078
142Endometrial cancer_Homo sapiens_hsa052130.16902639
143Homologous recombination_Homo sapiens_hsa034400.14934812
144Choline metabolism in cancer_Homo sapiens_hsa052310.14636176
145Fanconi anemia pathway_Homo sapiens_hsa034600.14628815
146Dorso-ventral axis formation_Homo sapiens_hsa043200.14336976
147Glycosaminoglycan degradation_Homo sapiens_hsa005310.14246845
148Linoleic acid metabolism_Homo sapiens_hsa005910.14020563
149HIF-1 signaling pathway_Homo sapiens_hsa040660.13923796
150Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.13589277
151alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13584001
152Ras signaling pathway_Homo sapiens_hsa040140.13031072
153Gap junction_Homo sapiens_hsa045400.12958024
154Protein digestion and absorption_Homo sapiens_hsa049740.12924838
155Insulin signaling pathway_Homo sapiens_hsa049100.11638309
156Phospholipase D signaling pathway_Homo sapiens_hsa040720.10422464
157Glioma_Homo sapiens_hsa052140.10010019
158Sphingolipid metabolism_Homo sapiens_hsa006000.09839324
159Biosynthesis of amino acids_Homo sapiens_hsa012300.09683969
160Oocyte meiosis_Homo sapiens_hsa041140.09589403
161Prolactin signaling pathway_Homo sapiens_hsa049170.09233695
162Chemokine signaling pathway_Homo sapiens_hsa040620.08877781

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