USF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the basic helix-loop-helix leucine zipper family of transcription factors. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.07214673
2positive regulation of histone deacetylation (GO:0031065)3.97287221
3growth hormone receptor signaling pathway (GO:0060396)3.93930097
4L-phenylalanine metabolic process (GO:0006558)3.93047445
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.93047445
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.91397112
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.87819322
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.86396669
9positive regulation by organism of defense response of other organism involved in symbiotic interact3.86396669
10modulation by symbiont of host immune response (GO:0052553)3.86396669
11positive regulation by symbiont of host defense response (GO:0052509)3.86396669
12modulation by symbiont of host defense response (GO:0052031)3.86396669
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.86396669
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.76778084
15L-phenylalanine catabolic process (GO:0006559)3.76778084
16mannose metabolic process (GO:0006013)3.67836736
17response to peptidoglycan (GO:0032494)3.66908386
18antigen processing and presentation of endogenous antigen (GO:0019883)3.66213097
19alpha-linolenic acid metabolic process (GO:0036109)3.63745702
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.62461001
21positive regulation of fatty acid beta-oxidation (GO:0032000)3.57668447
22macrophage activation involved in immune response (GO:0002281)3.51240015
23negative regulation of cell killing (GO:0031342)3.47245096
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.47245096
25regulation of cholesterol homeostasis (GO:2000188)3.43124225
26cellular response to growth hormone stimulus (GO:0071378)3.38256582
27regulation of fatty acid beta-oxidation (GO:0031998)3.33029356
28protein localization to endosome (GO:0036010)3.32363116
29neutrophil activation involved in immune response (GO:0002283)3.31684679
30response to muramyl dipeptide (GO:0032495)3.31509616
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.28912659
32detection of other organism (GO:0098543)3.20957779
33detection of bacterium (GO:0016045)3.19386415
34regulation of gamma-delta T cell activation (GO:0046643)3.18792856
35protein carboxylation (GO:0018214)3.18511630
36peptidyl-glutamic acid carboxylation (GO:0017187)3.18511630
37sulfur amino acid catabolic process (GO:0000098)3.14614759
38germinal center formation (GO:0002467)3.08988402
39negative regulation of interleukin-12 production (GO:0032695)3.08254911
40positive regulation of triglyceride biosynthetic process (GO:0010867)3.06691035
41positive regulation of lipid catabolic process (GO:0050996)3.04411444
42maternal placenta development (GO:0001893)3.04054534
43regulation of early endosome to late endosome transport (GO:2000641)3.03840308
44dicarboxylic acid biosynthetic process (GO:0043650)3.03821809
45regulation of leukocyte degranulation (GO:0043300)3.03294274
46regulation of cholesterol storage (GO:0010885)3.03142834
47regulation of triglyceride catabolic process (GO:0010896)2.99588461
48negative regulation of fibrinolysis (GO:0051918)2.98927824
49lysine catabolic process (GO:0006554)2.98884811
50lysine metabolic process (GO:0006553)2.98884811
51plasma lipoprotein particle clearance (GO:0034381)2.98324207
52glyoxylate metabolic process (GO:0046487)2.96010083
53kynurenine metabolic process (GO:0070189)2.95906830
54urea cycle (GO:0000050)2.95438036
55urea metabolic process (GO:0019627)2.95438036
56barbed-end actin filament capping (GO:0051016)2.95256965
57aromatic amino acid family catabolic process (GO:0009074)2.94940492
58regulation of T-helper 2 cell differentiation (GO:0045628)2.94610168
59modulation by symbiont of host cellular process (GO:0044068)2.93477459
60cellular modified amino acid catabolic process (GO:0042219)2.93462084
61regulation of myeloid leukocyte mediated immunity (GO:0002886)2.88862712
62high-density lipoprotein particle remodeling (GO:0034375)2.88537878
63positive regulation of fatty acid oxidation (GO:0046321)2.88253805
64leukocyte aggregation (GO:0070486)2.88057627
65negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.86474668
66thymic T cell selection (GO:0045061)2.86025239
67negative regulation of sterol transport (GO:0032372)2.85835341
68negative regulation of cholesterol transport (GO:0032375)2.85835341
69regulation of mast cell degranulation (GO:0043304)2.85112692
70positive regulation of triglyceride metabolic process (GO:0090208)2.85112443
71NIK/NF-kappaB signaling (GO:0038061)2.84253154
72lipopolysaccharide-mediated signaling pathway (GO:0031663)2.83360669
73negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.82626600
74immunoglobulin mediated immune response (GO:0016064)2.81668058
75modulation by virus of host process (GO:0019054)2.81010287
76fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.79968412
77complement activation, alternative pathway (GO:0006957)2.79849770
78negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.78056462
792-oxoglutarate metabolic process (GO:0006103)2.77840793
80protein-lipid complex assembly (GO:0065005)2.76613059
81regulation of p38MAPK cascade (GO:1900744)2.76162933
82cellular response to thyroid hormone stimulus (GO:0097067)2.75244154
83creatine metabolic process (GO:0006600)2.75044030
84signal complex assembly (GO:0007172)2.74394932
85bile acid biosynthetic process (GO:0006699)2.74026263
86phospholipid efflux (GO:0033700)2.72577665
87regulation of cholesterol esterification (GO:0010872)2.72045734
88regulation of ARF protein signal transduction (GO:0032012)2.71969881
89nitrogen cycle metabolic process (GO:0071941)2.71536019
90JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.70266454
91positive regulation of cellular amide metabolic process (GO:0034250)2.70165645
92glutamate metabolic process (GO:0006536)2.70068281
93cysteine metabolic process (GO:0006534)2.69864621
94antigen processing and presentation via MHC class Ib (GO:0002475)2.68625466
95detection of external biotic stimulus (GO:0098581)2.67882734
96plasma lipoprotein particle assembly (GO:0034377)2.65806810
97sodium ion export (GO:0071436)2.63650846
98stress fiber assembly (GO:0043149)2.63081670
99regulation of fatty acid oxidation (GO:0046320)2.63039427
100response to growth hormone (GO:0060416)2.62466173
101regulation of fibrinolysis (GO:0051917)2.62129301
102activation of MAPKKK activity (GO:0000185)2.61527013
103regulation of triglyceride biosynthetic process (GO:0010866)2.61368465
104ethanol oxidation (GO:0006069)2.61097552
105glycosphingolipid catabolic process (GO:0046479)2.60230674
106regulation of regulated secretory pathway (GO:1903305)2.59999668
107regulation of interferon-beta biosynthetic process (GO:0045357)2.59708183
108negative regulation of cell size (GO:0045792)2.59244527
109cholesterol efflux (GO:0033344)2.59018178
110negative regulation of potassium ion transmembrane transport (GO:1901380)2.58484414
111amino sugar catabolic process (GO:0046348)2.58380978
112adenosine receptor signaling pathway (GO:0001973)2.58045987
113plasma lipoprotein particle remodeling (GO:0034369)2.57554903
114protein-lipid complex remodeling (GO:0034368)2.57554903
115macromolecular complex remodeling (GO:0034367)2.57554903
116negative regulation of toll-like receptor signaling pathway (GO:0034122)2.56838287
117positive thymic T cell selection (GO:0045059)2.56103364
118T cell selection (GO:0045058)2.54091580
119regulation of ARF GTPase activity (GO:0032312)2.52926498
120positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.52191656
121phospholipid homeostasis (GO:0055091)2.51557773
122negative regulation of erythrocyte differentiation (GO:0045647)2.51251640
123low-density lipoprotein particle clearance (GO:0034383)2.50962625
124negative regulation of leukocyte mediated immunity (GO:0002704)2.50794375
125myeloid dendritic cell differentiation (GO:0043011)2.50415408
126positive regulation of protein deacetylation (GO:0090312)2.50283180
127epithelial cell differentiation involved in prostate gland development (GO:0060742)2.49124975
128response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.49098888
129response to host immune response (GO:0052572)2.49098888
130positive regulation of protein dephosphorylation (GO:0035307)2.48218335
131reverse cholesterol transport (GO:0043691)2.48165128
132response to laminar fluid shear stress (GO:0034616)2.48127384
133fatty acid transmembrane transport (GO:1902001)2.47954201
134amino-acid betaine metabolic process (GO:0006577)2.47436092
135positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.47291238
136positive regulation of Cdc42 GTPase activity (GO:0043089)2.46163240
137regulation of triglyceride metabolic process (GO:0090207)2.45961754
138regulation of mast cell activation involved in immune response (GO:0033006)2.44872685
139triglyceride homeostasis (GO:0070328)2.44627610
140acylglycerol homeostasis (GO:0055090)2.44627610
141negative regulation of granulocyte differentiation (GO:0030853)2.44221966
142B cell receptor signaling pathway (GO:0050853)2.43779956
143regulation of protein activation cascade (GO:2000257)2.43631123
144regulation of extracellular matrix disassembly (GO:0010715)2.43590072
145response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.42080990
146response to host (GO:0075136)2.42080990
147response to host defenses (GO:0052200)2.42080990
148positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.41851552
149regulation of defense response to virus by virus (GO:0050690)2.40895474
150negative regulation of cytokine production involved in immune response (GO:0002719)2.40653214
151negative regulation of nucleotide catabolic process (GO:0030812)2.40614610
152regulation of lipid catabolic process (GO:0050994)2.40575161
153aspartate family amino acid catabolic process (GO:0009068)2.39966433
154regulation of superoxide anion generation (GO:0032928)2.39007643
155negative regulation of heart growth (GO:0061117)2.38739084
156negative regulation of cardiac muscle tissue growth (GO:0055022)2.38739084
157regulation of B cell receptor signaling pathway (GO:0050855)2.38319319
158negative regulation of lipid transport (GO:0032369)2.37585473
159positive regulation of lipid storage (GO:0010884)2.37473209
160regulation of gamma-delta T cell differentiation (GO:0045586)2.37331620
161myeloid cell activation involved in immune response (GO:0002275)2.37076875
162cholesterol homeostasis (GO:0042632)2.36796068
163positive T cell selection (GO:0043368)2.36469104
164negative regulation of innate immune response (GO:0045824)2.36437544
165tolerance induction (GO:0002507)2.36170913
166sterol homeostasis (GO:0055092)2.36152525
167pinocytosis (GO:0006907)2.35340351
168detection of biotic stimulus (GO:0009595)2.34661302
169detection of molecule of bacterial origin (GO:0032490)2.34427436
170protein-lipid complex subunit organization (GO:0071825)2.34253502
171positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.34137293
172cellular extravasation (GO:0045123)2.33909456
173positive regulation of B cell differentiation (GO:0045579)2.33003871
174macrophage activation (GO:0042116)2.32068664
1753-UTR-mediated mRNA stabilization (GO:0070935)2.32064719
176negative regulation of lymphocyte mediated immunity (GO:0002707)2.32054430
177bile acid metabolic process (GO:0008206)2.31926769
178activation of JUN kinase activity (GO:0007257)2.31243260
179pentose-phosphate shunt (GO:0006098)2.31030352
180positive regulation of Rap GTPase activity (GO:0032854)2.30812704
181positive regulation of receptor recycling (GO:0001921)2.30793209
182interferon-gamma-mediated signaling pathway (GO:0060333)2.30763172
183cellular ketone body metabolic process (GO:0046950)2.30641045
184regulation of type I interferon-mediated signaling pathway (GO:0060338)2.30341904
185glycolipid catabolic process (GO:0019377)2.29772808
186acetyl-CoA metabolic process (GO:0006084)2.29350066
187apoptotic process involved in morphogenesis (GO:0060561)2.28617427
188cortical actin cytoskeleton organization (GO:0030866)2.28580554
189regulation of complement activation (GO:0030449)2.27833992
190positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.27521377

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.61778151
2* RXR_22158963_ChIP-Seq_LIVER_Mouse3.55839572
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.29061218
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.25376766
5* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.73192400
6* LXR_22158963_ChIP-Seq_LIVER_Mouse2.71739014
7VDR_21846776_ChIP-Seq_THP-1_Human2.68946399
8KDM2B_26808549_Chip-Seq_DND41_Human2.68244086
9MYC_22102868_ChIP-Seq_BL_Human2.64554791
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.60100894
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.59141768
12LXR_22292898_ChIP-Seq_THP-1_Human2.58949828
13TCF7_22412390_ChIP-Seq_EML_Mouse2.38568791
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.27013678
15* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.21564189
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.21366193
17* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.12669327
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.09173053
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.01963851
20KDM2B_26808549_Chip-Seq_K562_Human1.94806998
21MAF_26560356_Chip-Seq_TH1_Human1.91324385
22KDM2B_26808549_Chip-Seq_JURKAT_Human1.88318353
23RACK7_27058665_Chip-Seq_MCF-7_Human1.83033942
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81529969
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.80601114
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77137574
27ZNF263_19887448_ChIP-Seq_K562_Human1.76022395
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.71982189
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69572049
30VDR_24763502_ChIP-Seq_THP-1_Human1.69149396
31UTX_26944678_Chip-Seq_JUKART_Human1.66969823
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65365256
33GATA1_19941826_ChIP-Seq_K562_Human1.54062792
34CLOCK_20551151_ChIP-Seq_293T_Human1.52165169
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.52048127
36P300_27058665_Chip-Seq_ZR-75-30cells_Human1.51282239
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50889749
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50262199
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48687126
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48574854
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46944921
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45693004
43CREB1_26743006_Chip-Seq_LNCaP_Human1.44030177
44CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43231456
45TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42971892
46TET1_21451524_ChIP-Seq_MESCs_Mouse1.41084607
47* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.40969687
48SMC4_20622854_ChIP-Seq_HELA_Human1.38705152
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.38625343
50* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38499406
51SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38068756
52SCL_19346495_ChIP-Seq_HPC-7_Human1.37678888
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.36568027
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35894120
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34354065
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31814365
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31569010
58* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31527373
59MAF_26560356_Chip-Seq_TH2_Human1.31269656
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30936537
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30670260
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.29953386
63NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29282221
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29157337
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.28528214
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28219581
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28178822
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27113774
69TBX20_22080862_ChIP-Seq_HEART_Mouse1.27056833
70TBX20_22328084_ChIP-Seq_HEART_Mouse1.27056833
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.25408413
72* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23992534
73P68_20966046_ChIP-Seq_HELA_Human1.23546135
74* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23541691
75* IRF8_27001747_Chip-Seq_BMDM_Mouse1.22331895
76SPI1_23127762_ChIP-Seq_K562_Human1.22024980
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21007882
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20740169
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20172675
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19537566
81BCL6_27268052_Chip-Seq_Bcells_Human1.19163645
82EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18681720
83BCOR_27268052_Chip-Seq_Bcells_Human1.18545231
84MYB_21317192_ChIP-Seq_ERMYB_Mouse1.18454361
85CTCF_21964334_ChIP-Seq_BJAB-B_Human1.18110354
86SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15296549
87NCOR1_26117541_ChIP-Seq_K562_Human1.14758053
88PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14568167
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12652128
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10021268
91IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09800350
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09187431
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.09023205
94ATF3_27146783_Chip-Seq_COLON_Human1.08408626
95RUNX_20019798_ChIP-Seq_JUKART_Human1.07775731
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07323215
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07063833
98NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06973267
99PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06956396
100SPI1_23547873_ChIP-Seq_NB4_Human1.05207567
101CTCF_21964334_Chip-Seq_Bcells_Human1.05154379
102NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05103086
103* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04490779
104FOXO3_23340844_ChIP-Seq_DLD1_Human1.03222537
105RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02538649
106GATA2_19941826_ChIP-Seq_K562_Human1.02311919
107SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01594056
108SPI1_20517297_ChIP-Seq_HL60_Human1.01076117
109RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00428422
110FOXA2_19822575_ChIP-Seq_HepG2_Human1.00292842
111FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99686591
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99372624
113LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99174897
114SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98473675
115RUNX1_27514584_Chip-Seq_MCF-7_Human0.98265208
116IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98187753
117* CTCF_26484167_Chip-Seq_Bcells_Mouse0.97348560
118* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97313787
119GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96948240
120EGR1_19374776_ChIP-ChIP_THP-1_Human0.96248894
121* RUNX1_22412390_ChIP-Seq_EML_Mouse0.96232464
122CTCF_27219007_Chip-Seq_Bcells_Human0.95329706
123EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94391651
124SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93891876
125ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92636046
126VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91758271
127SA1_27219007_Chip-Seq_Bcells_Human0.91677997
128SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91381427

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.19325633
2MP0002139_abnormal_hepatobiliary_system3.98547382
3MP0003303_peritoneal_inflammation3.82346194
4MP0009840_abnormal_foam_cell3.34465151
5MP0005085_abnormal_gallbladder_physiolo3.09221724
6MP0002138_abnormal_hepatobiliary_system3.08379402
7MP0003705_abnormal_hypodermis_morpholog3.08266393
8MP0004185_abnormal_adipocyte_glucose2.94757403
9MP0003191_abnormal_cellular_cholesterol2.85266864
10MP0003300_gastrointestinal_ulcer2.81493141
11MP0005365_abnormal_bile_salt2.80000411
12MP0005083_abnormal_biliary_tract2.54460836
13MP0003252_abnormal_bile_duct2.29770573
14MP0003724_increased_susceptibility_to2.22156035
15MP0001835_abnormal_antigen_presentation2.21666665
16MP0010329_abnormal_lipoprotein_level2.16165116
17MP0008875_abnormal_xenobiotic_pharmacok2.15623322
18MP0004510_myositis2.08190750
19MP0004130_abnormal_muscle_cell2.04171860
20MP0008260_abnormal_autophagy2.02672517
21MP0005671_abnormal_response_to1.91974109
22MP0005666_abnormal_adipose_tissue1.84596243
23MP0008961_abnormal_basal_metabolism1.78731262
24MP0002148_abnormal_hypersensitivity_rea1.77082964
25MP0003763_abnormal_thymus_physiology1.74008789
26MP0001533_abnormal_skeleton_physiology1.72063147
27MP0009333_abnormal_splenocyte_physiolog1.71844047
28MP0000685_abnormal_immune_system1.67916378
29MP0000609_abnormal_liver_physiology1.66781131
30MP0002837_dystrophic_cardiac_calcinosis1.63145915
31MP0002998_abnormal_bone_remodeling1.62807584
32MP0005058_abnormal_lysosome_morphology1.61221900
33MP0009785_altered_susceptibility_to1.59937681
34MP0003075_altered_response_to1.56543470
35MP0003436_decreased_susceptibility_to1.55208534
36MP0002118_abnormal_lipid_homeostasis1.52861125
37MP0010155_abnormal_intestine_physiology1.51681527
38MP0009278_abnormal_bone_marrow1.51249921
39MP0000858_altered_metastatic_potential1.46365336
40MP0005375_adipose_tissue_phenotype1.42172027
41MP0005330_cardiomyopathy1.41481777
42MP0004087_abnormal_muscle_fiber1.38956892
43MP0003656_abnormal_erythrocyte_physiolo1.37719979
44MP0006082_CNS_inflammation1.36403541
45MP0005464_abnormal_platelet_physiology1.33474106
46MP0003828_pulmonary_edema1.32712244
47MP0000343_altered_response_to1.32391802
48MP0000716_abnormal_immune_system1.29819966
49MP0001849_ear_inflammation1.29564081
50MP0002398_abnormal_bone_marrow1.27979232
51MP0003879_abnormal_hair_cell1.27745002
52MP0005387_immune_system_phenotype1.26153730
53MP0001790_abnormal_immune_system1.26153730
54MP0001845_abnormal_inflammatory_respons1.26059956
55MP0005332_abnormal_amino_acid1.24762229
56MP0002971_abnormal_brown_adipose1.24194394
57MP0003690_abnormal_glial_cell1.23846928
58MP0005076_abnormal_cell_differentiation1.23823685
59MP0000604_amyloidosis1.23079548
60MP0002877_abnormal_melanocyte_morpholog1.21533608
61MP0003183_abnormal_peptide_metabolism1.20713228
62MP0010630_abnormal_cardiac_muscle1.20371122
63MP0000751_myopathy1.20079719
64MP0005584_abnormal_enzyme/coenzyme_acti1.18467431
65MP0005670_abnormal_white_adipose1.16369931
66MP0003091_abnormal_cell_migration1.16294588
67MP0005451_abnormal_body_composition1.14570020
68MP0005319_abnormal_enzyme/_coenzyme1.14433927
69MP0001545_abnormal_hematopoietic_system1.13012552
70MP0005397_hematopoietic_system_phenotyp1.13012552
71MP0001666_abnormal_nutrient_absorption1.12971923
72MP0005310_abnormal_salivary_gland1.11899708
73MP0004381_abnormal_hair_follicle1.08946183
74MP0001873_stomach_inflammation1.07566942
75MP0003453_abnormal_keratinocyte_physiol1.06999617
76MP0005167_abnormal_blood-brain_barrier1.05416596
77MP0004859_abnormal_synaptic_plasticity1.04506826
78MP0002429_abnormal_blood_cell1.04416874
79MP0008874_decreased_physiological_sensi1.02597547
80MP0003566_abnormal_cell_adhesion1.00923771
81MP0004084_abnormal_cardiac_muscle0.99707383
82MP0002722_abnormal_immune_system0.99635135
83MP0001800_abnormal_humoral_immune0.97959438
84MP0005409_darkened_coat_color0.97784922
85MP0009643_abnormal_urine_homeostasis0.97494118
86MP0003866_abnormal_defecation0.97322311
87MP0003172_abnormal_lysosome_physiology0.96270391
88MP0000703_abnormal_thymus_morphology0.95026912
89MP0003646_muscle_fatigue0.94192635
90MP0000747_muscle_weakness0.93388294
91MP0000598_abnormal_liver_morphology0.92742494
92MP0000689_abnormal_spleen_morphology0.92659685
93MP0005025_abnormal_response_to0.90440676
94MP0003448_altered_tumor_morphology0.89431894
95MP0002933_joint_inflammation0.88484120
96MP0001544_abnormal_cardiovascular_syste0.88266512
97MP0005385_cardiovascular_system_phenoty0.88266512
98MP0003329_amyloid_beta_deposits0.88260972
99MP0004858_abnormal_nervous_system0.87677028
100MP0003634_abnormal_glial_cell0.86974575
101MP0004036_abnormal_muscle_relaxation0.86671146
102MP0005000_abnormal_immune_tolerance0.86046045
103MP0008469_abnormal_protein_level0.84344806
104MP0000750_abnormal_muscle_regeneration0.84189308
105MP0005334_abnormal_fat_pad0.82944981
106MP0005390_skeleton_phenotype0.82618810
107MP0000678_abnormal_parathyroid_gland0.82492414
108MP0003011_delayed_dark_adaptation0.82010997
109MP0004947_skin_inflammation0.81578016
110MP0009764_decreased_sensitivity_to0.81362192
111MP0010368_abnormal_lymphatic_system0.80963834
112MP0002078_abnormal_glucose_homeostasis0.80638466
113MP0001663_abnormal_digestive_system0.79509483
114MP0005166_decreased_susceptibility_to0.79455471
115MP0003868_abnormal_feces_composition0.79332186
116MP0003279_aneurysm0.78606187
117MP0002452_abnormal_antigen_presenting0.78248762
118MP0000003_abnormal_adipose_tissue0.77935497
119MP0002419_abnormal_innate_immunity0.77464344
120MP0002723_abnormal_immune_serum0.77443672
121MP0000749_muscle_degeneration0.77398824
122MP0002796_impaired_skin_barrier0.76586680
123MP0000759_abnormal_skeletal_muscle0.76412058
124MP0009763_increased_sensitivity_to0.75406797
125MP0001348_abnormal_lacrimal_gland0.75070178
126MP0004808_abnormal_hematopoietic_stem0.74171218
127MP0008775_abnormal_heart_ventricle0.73828730
128MP0008569_lethality_at_weaning0.72554567
129MP0002269_muscular_atrophy0.72028043
130MP0005165_increased_susceptibility_to0.72009531
131MP0000920_abnormal_myelination0.71691342
132MP0002970_abnormal_white_adipose0.71468023
133MP0008004_abnormal_stomach_pH0.70227798
134MP0003045_fibrosis0.69691554
135MP0000249_abnormal_blood_vessel0.69550819
136MP0010234_abnormal_vibrissa_follicle0.69330478
137MP0002420_abnormal_adaptive_immunity0.68506796
138MP0002106_abnormal_muscle_physiology0.68478411
139MP0002972_abnormal_cardiac_muscle0.67824405
140MP0003795_abnormal_bone_structure0.67660676
141MP0001819_abnormal_immune_cell0.67585352
142MP0000733_abnormal_muscle_development0.66649938
143MP0009115_abnormal_fat_cell0.66091945
144MP0002405_respiratory_system_inflammati0.65075273
145MP0002254_reproductive_system_inflammat0.64983785
146MP0001853_heart_inflammation0.64759247
147MP0006138_congestive_heart_failure0.64017583
148MP0001851_eye_inflammation0.63482308

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.58631079
2Abnormality of glycolipid metabolism (HP:0010969)3.77317140
3Abnormality of liposaccharide metabolism (HP:0010968)3.77317140
4Abnormality of glycosphingolipid metabolism (HP:0004343)3.77317140
5Xanthomatosis (HP:0000991)3.74577372
6Abnormality of macrophages (HP:0004311)3.55449288
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.33454010
8Recurrent abscess formation (HP:0002722)3.29161968
9Complement deficiency (HP:0004431)3.21492362
10Recurrent bacterial skin infections (HP:0005406)3.21014682
11Abnormality of the Achilles tendon (HP:0005109)3.16829476
12Hyperlipoproteinemia (HP:0010980)3.10965625
13Obstructive sleep apnea (HP:0002870)3.02256386
14Increased neuronal autofluorescent lipopigment (HP:0002074)2.99866381
15Achilles tendon contracture (HP:0001771)2.97778993
16Myocardial infarction (HP:0001658)2.87874315
17Intrahepatic cholestasis (HP:0001406)2.86701545
18Polycythemia (HP:0001901)2.86659023
19Abnormality of complement system (HP:0005339)2.81535735
20Ketosis (HP:0001946)2.79313760
21Joint hemorrhage (HP:0005261)2.75013709
22Sudden death (HP:0001699)2.72975902
23Abnormality of monocarboxylic acid metabolism (HP:0010996)2.70719613
24Eczematoid dermatitis (HP:0000976)2.70676726
25Loss of speech (HP:0002371)2.68816990
26Systemic lupus erythematosus (HP:0002725)2.68000479
27Purpura (HP:0000979)2.66706285
28Hepatoblastoma (HP:0002884)2.64866776
29Asymmetric septal hypertrophy (HP:0001670)2.62667138
30Ketoacidosis (HP:0001993)2.62658837
31Mediastinal lymphadenopathy (HP:0100721)2.58719237
32Myositis (HP:0100614)2.51487404
33Chronic obstructive pulmonary disease (HP:0006510)2.50214434
34Obstructive lung disease (HP:0006536)2.50214434
35Hyporeflexia of lower limbs (HP:0002600)2.49691120
36Ventricular tachycardia (HP:0004756)2.49316278
37Recurrent gram-negative bacterial infections (HP:0005420)2.46427183
38Hypercholesterolemia (HP:0003124)2.45497618
39Centrally nucleated skeletal muscle fibers (HP:0003687)2.44806626
40Neonatal hypoglycemia (HP:0001998)2.44298500
41Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.42931614
42Increased IgE level (HP:0003212)2.41809878
43Gastrointestinal stroma tumor (HP:0100723)2.39524800
44Distal lower limb muscle weakness (HP:0009053)2.39050734
45Axonal loss (HP:0003447)2.35442494
46Orchitis (HP:0100796)2.34462424
47Gingivitis (HP:0000230)2.33023507
48Myoglobinuria (HP:0002913)2.30416155
49Hyperammonemia (HP:0001987)2.30022422
50Meningitis (HP:0001287)2.28238654
51Hypoalphalipoproteinemia (HP:0003233)2.27142488
52Amyloidosis (HP:0011034)2.21174758
53Exercise-induced myalgia (HP:0003738)2.20344882
54Reticulocytosis (HP:0001923)2.19887405
55Spontaneous hematomas (HP:0007420)2.19839021
56Cerebral aneurysm (HP:0004944)2.19153697
57Late onset (HP:0003584)2.19048244
58Verrucae (HP:0200043)2.18317250
59Papilloma (HP:0012740)2.18317250
60Cellulitis (HP:0100658)2.15367908
61Increased connective tissue (HP:0009025)2.15155020
62Distal lower limb amyotrophy (HP:0008944)2.14533101
63Skin nodule (HP:0200036)2.13357300
64Exercise-induced muscle cramps (HP:0003710)2.13092716
65Segmental peripheral demyelination/remyelination (HP:0003481)2.11622366
66Dysostosis multiplex (HP:0000943)2.11592366
67Vertebral compression fractures (HP:0002953)2.10811750
68Increased cerebral lipofuscin (HP:0011813)2.10177195
69Increased variability in muscle fiber diameter (HP:0003557)2.07635054
70Back pain (HP:0003418)2.07453782
71Polygenic inheritance (HP:0010982)2.06890997
72J-shaped sella turcica (HP:0002680)2.04690500
73Hypoglycemic coma (HP:0001325)2.04247589
74Cholelithiasis (HP:0001081)2.04167568
75Slow saccadic eye movements (HP:0000514)2.03322975
76Recurrent fungal infections (HP:0002841)2.02700644
77Hypobetalipoproteinemia (HP:0003563)2.02238118
78Petechiae (HP:0000967)2.01950628
79Prolonged bleeding time (HP:0003010)2.01945113
80Vacuolated lymphocytes (HP:0001922)2.00931286
81Nuclear cataract (HP:0100018)2.00685950
82Emphysema (HP:0002097)2.00532803
83Urinary glycosaminoglycan excretion (HP:0003541)2.00320869
84Mucopolysacchariduria (HP:0008155)2.00320869
85Apathy (HP:0000741)2.00043457
86Abnormality of skeletal muscle fiber size (HP:0012084)2.00021381
87Abnormality of glutamine family amino acid metabolism (HP:0010902)1.99980987
88Glomerulonephritis (HP:0000099)1.99623947
89Difficulty running (HP:0009046)1.98473389
90Pseudobulbar signs (HP:0002200)1.98459353
91Abnormality of the common coagulation pathway (HP:0010990)1.98083626
92Impaired platelet aggregation (HP:0003540)1.97887700
93Abnormal platelet function (HP:0011869)1.97887700
94Recurrent skin infections (HP:0001581)1.97679308
95Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.97430198
96Hypolipoproteinemia (HP:0010981)1.95067236
97Menorrhagia (HP:0000132)1.94138947
98Thin bony cortex (HP:0002753)1.93921863
99Diminished motivation (HP:0000745)1.93022474
100Retrobulbar optic neuritis (HP:0100654)1.91745971
101Optic neuritis (HP:0100653)1.91745971
102Epidermoid cyst (HP:0200040)1.91388216
103Muscle fiber splitting (HP:0003555)1.90701649
104Cardiomegaly (HP:0001640)1.89944002
105Esophageal varix (HP:0002040)1.89566772
106Myopathic facies (HP:0002058)1.89495682
107Mutism (HP:0002300)1.89384862
108Diastasis recti (HP:0001540)1.89069896
109Rapidly progressive (HP:0003678)1.88374508
110Peripheral hypomyelination (HP:0007182)1.88323189
111Abnormal gallbladder morphology (HP:0012437)1.88155795
112Gingival bleeding (HP:0000225)1.88007970
113Cerebral inclusion bodies (HP:0100314)1.87846237
114Elevated erythrocyte sedimentation rate (HP:0003565)1.87732361
115Bulbar palsy (HP:0001283)1.87545993
116Ankle clonus (HP:0011448)1.87479901
117Restrictive lung disease (HP:0002091)1.86942006
118Colitis (HP:0002583)1.85922530
119Vasculitis (HP:0002633)1.85215971
120Overgrowth (HP:0001548)1.85149970
121Gastrointestinal infarctions (HP:0005244)1.85116195
122Lymphangioma (HP:0100764)1.85046558
123Hypercortisolism (HP:0001578)1.84462614
124Thoracic kyphosis (HP:0002942)1.84096586
125Hyperacusis (HP:0010780)1.83098840
126Mitral valve prolapse (HP:0001634)1.82966161
127Supranuclear gaze palsy (HP:0000605)1.82609850
128Urticaria (HP:0001025)1.82416221
129Hemorrhage of the eye (HP:0011885)1.82174794
130Disproportionate tall stature (HP:0001519)1.81424810
131Broad face (HP:0000283)1.80974626
132Abnormality of the fingertips (HP:0001211)1.80387174
133Recurrent viral infections (HP:0004429)1.79911310
134Abnormality of binocular vision (HP:0011514)1.79253144
135Diplopia (HP:0000651)1.79253144
136Conjunctival hamartoma (HP:0100780)1.77747467
137Hypochromic microcytic anemia (HP:0004840)1.76511569
138Prolonged partial thromboplastin time (HP:0003645)1.76405056
139Neurofibrillary tangles (HP:0002185)1.76275961
140Hypertriglyceridemia (HP:0002155)1.75288057
141Hamartoma of the eye (HP:0010568)1.75233114
142Right ventricular cardiomyopathy (HP:0011663)1.74548236
143Interstitial pulmonary disease (HP:0006530)1.74178257
144Abnormality of the thoracic spine (HP:0100711)1.74056507
145Global brain atrophy (HP:0002283)1.72962084
146Epistaxis (HP:0000421)1.72915240
147Abnormality of the nasal mucosa (HP:0000433)1.72634980
148Upper motor neuron abnormality (HP:0002127)1.72505771
149Hyperinsulinemic hypoglycemia (HP:0000825)1.72051618
150Multiple lipomas (HP:0001012)1.71967401
151Hyperparathyroidism (HP:0000843)1.71657123
152Hyperbilirubinemia (HP:0002904)1.71134282
153Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.71076188
154Dementia (HP:0000726)1.70828105
155Abnormality of mucopolysaccharide metabolism (HP:0011020)1.69803635
156Abnormality of polysaccharide metabolism (HP:0011012)1.69803635
157Abnormality of glycosaminoglycan metabolism (HP:0004371)1.69803635
158Gastrointestinal inflammation (HP:0004386)1.69445985
159Increased CSF protein (HP:0002922)1.69290970
160Inflammation of the large intestine (HP:0002037)1.68869917
161Poikilocytosis (HP:0004447)1.68464032
162Neuronal loss in central nervous system (HP:0002529)1.66727334
163Upper limb amyotrophy (HP:0009129)1.65647994
164Distal upper limb amyotrophy (HP:0007149)1.65647994
165Neonatal onset (HP:0003623)1.63920274
166Increased serum ferritin (HP:0003281)1.63523038
167Hypochromic anemia (HP:0001931)1.62908414
168Aneurysm (HP:0002617)1.62682236
169EMG: neuropathic changes (HP:0003445)1.62386800

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.36439900
2PRPF4B4.19665534
3PKN23.78955882
4MAP3K103.60614496
5ERN12.98348771
6RIPK12.51948168
7IRAK32.27605513
8MAP4K12.25099652
9SIK12.16338161
10EPHB12.14869863
11SMG12.13414930
12MAP3K131.85843382
13EEF2K1.83969393
14TAOK21.83788723
15PTK61.83568013
16GRK61.79956110
17SIK21.72200030
18TTN1.66316946
19ICK1.59437965
20DMPK1.57502049
21BMX1.55062053
22LRRK21.46638963
23FGFR41.44664549
24BLK1.44652069
25PRKD21.40444179
26TNK21.38283318
27HIPK21.34388052
28MAP3K31.33124670
29ALK1.31575065
30CDC42BPA1.26077822
31MAP3K141.24802320
32CSK1.22782338
33TAOK31.21912211
34PRKG21.21132392
35TYRO31.20232849
36TAOK11.20157633
37TGFBR21.18678667
38JAK21.11640529
39KSR21.11609885
40ARAF1.10741893
41SIK31.10148528
42MAP3K71.09178123
43STK101.08719660
44CDK121.06987868
45FES1.06764536
46TYK21.03182109
47TBK11.03035887
48BCKDK1.02800722
49PRKD11.02157119
50DYRK1B0.99194115
51MAP3K110.88996378
52PRKCH0.88850425
53PAK60.88206989
54RET0.87818003
55HCK0.84439775
56JAK30.84225845
57CSF1R0.82110180
58CDK60.80100162
59TESK20.78252955
60NME20.78086753
61UHMK10.76902017
62PDPK10.76610249
63DDR20.76313119
64PRKD30.76026282
65MAPK110.75164897
66DAPK20.74937681
67FGR0.74784358
68MARK20.73693202
69MOS0.73217030
70MAP3K10.71860537
71ZAP700.70717320
72RPS6KA20.69456580
73JAK10.68992376
74PDGFRA0.68674213
75CAMKK10.66836849
76IKBKE0.66064165
77TESK10.65579583
78ITK0.65512041
79ILK0.65487535
80BTK0.64998430
81CAMK1G0.64796624
82PDK10.63822003
83STK110.63602673
84MAP3K20.61748247
85MAPK70.61549074
86PHKG10.60634118
87PHKG20.60634118
88MAP2K30.60385856
89IRAK20.59045133
90STK380.58364339
91DAPK30.57863247
92RIPK40.57677008
93MAPK120.56837852
94WNK10.56143395
95MATK0.55010866
96CDK40.54997769
97CAMK1D0.54410775
98SGK30.51416202
99MAP3K90.51378382
100BRAF0.50958343
101TLK10.50528096
102IRAK10.50136033
103SYK0.49995937
104GSK3A0.49769949
105IKBKB0.49762272
106CAMK40.49245294
107RPS6KA60.49125767
108PDGFRB0.48637627
109RPS6KA10.48523252
110MAP2K20.48229124
111MTOR0.48211960
112LYN0.47534374
113CLK10.47034060
114MARK30.45282844
115FGFR30.45166700
116MAP3K60.44076138
117PAK40.43235793
118MAPK40.43028770
119NEK90.42836595
120LMTK20.40541460
121RPS6KC10.39239316
122RPS6KL10.39239316
123MAP2K60.38966971
124PRKCQ0.36380514
125LCK0.36059591
126IRAK40.35637383
127EPHA30.33939858

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.49139989
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.45347329
3Other glycan degradation_Homo sapiens_hsa005112.98603642
4Arginine biosynthesis_Homo sapiens_hsa002202.71566023
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.66549312
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.23322924
7Staphylococcus aureus infection_Homo sapiens_hsa051502.02387215
8Fatty acid degradation_Homo sapiens_hsa000712.02257924
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.95005714
10Complement and coagulation cascades_Homo sapiens_hsa046101.87909843
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.74202839
12Lysine degradation_Homo sapiens_hsa003101.72102225
13Tryptophan metabolism_Homo sapiens_hsa003801.70299401
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61577573
15PPAR signaling pathway_Homo sapiens_hsa033201.60906434
16Tuberculosis_Homo sapiens_hsa051521.58026688
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50055836
18Bile secretion_Homo sapiens_hsa049761.40430798
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38642597
20Allograft rejection_Homo sapiens_hsa053301.35212491
21Fatty acid metabolism_Homo sapiens_hsa012121.34127726
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31699140
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.30547150
24B cell receptor signaling pathway_Homo sapiens_hsa046621.28555679
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26387890
26Graft-versus-host disease_Homo sapiens_hsa053321.21191011
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.20398477
28Autoimmune thyroid disease_Homo sapiens_hsa053201.19042525
29TNF signaling pathway_Homo sapiens_hsa046681.16015797
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14906821
31Osteoclast differentiation_Homo sapiens_hsa043801.13160215
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10745331
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10223361
34Influenza A_Homo sapiens_hsa051641.08631290
35Insulin resistance_Homo sapiens_hsa049311.07960552
36Butanoate metabolism_Homo sapiens_hsa006501.06961494
37Malaria_Homo sapiens_hsa051441.06774572
38Viral myocarditis_Homo sapiens_hsa054161.06143884
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04939293
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04648607
41Acute myeloid leukemia_Homo sapiens_hsa052211.03099347
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03089220
43Hepatitis C_Homo sapiens_hsa051601.01808772
44Pertussis_Homo sapiens_hsa051331.01060763
45VEGF signaling pathway_Homo sapiens_hsa043701.00259505
46Adipocytokine signaling pathway_Homo sapiens_hsa049200.99775367
47Sulfur relay system_Homo sapiens_hsa041220.99532176
48Chronic myeloid leukemia_Homo sapiens_hsa052200.96894784
49Propanoate metabolism_Homo sapiens_hsa006400.95454436
50Non-small cell lung cancer_Homo sapiens_hsa052230.94609317
51Long-term potentiation_Homo sapiens_hsa047200.94560520
52Hepatitis B_Homo sapiens_hsa051610.94534132
53Phagosome_Homo sapiens_hsa041450.91371059
54Caffeine metabolism_Homo sapiens_hsa002320.91143099
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90000058
56Sphingolipid signaling pathway_Homo sapiens_hsa040710.89850445
57Salmonella infection_Homo sapiens_hsa051320.89210627
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.89059005
59ABC transporters_Homo sapiens_hsa020100.88934092
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88449455
61Antigen processing and presentation_Homo sapiens_hsa046120.87579705
62Measles_Homo sapiens_hsa051620.86672864
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86606668
64Histidine metabolism_Homo sapiens_hsa003400.85406685
65ErbB signaling pathway_Homo sapiens_hsa040120.84290696
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84271053
67Rheumatoid arthritis_Homo sapiens_hsa053230.84006161
68Type II diabetes mellitus_Homo sapiens_hsa049300.82735989
69Apoptosis_Homo sapiens_hsa042100.81901334
70Asthma_Homo sapiens_hsa053100.81668245
71Herpes simplex infection_Homo sapiens_hsa051680.80544767
72beta-Alanine metabolism_Homo sapiens_hsa004100.80530629
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80275989
74Platelet activation_Homo sapiens_hsa046110.80249246
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80019114
76Choline metabolism in cancer_Homo sapiens_hsa052310.79729218
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79675725
78Carbon metabolism_Homo sapiens_hsa012000.78705075
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.78061335
80Type I diabetes mellitus_Homo sapiens_hsa049400.77724966
81Insulin signaling pathway_Homo sapiens_hsa049100.76379779
82Leishmaniasis_Homo sapiens_hsa051400.76307816
83Starch and sucrose metabolism_Homo sapiens_hsa005000.76033523
84Fructose and mannose metabolism_Homo sapiens_hsa000510.74942024
85Biosynthesis of amino acids_Homo sapiens_hsa012300.74644921
86Fat digestion and absorption_Homo sapiens_hsa049750.73611146
87mTOR signaling pathway_Homo sapiens_hsa041500.73346379
88Renal cell carcinoma_Homo sapiens_hsa052110.72211701
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71745800
90Hematopoietic cell lineage_Homo sapiens_hsa046400.71261499
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70308019
92Pentose phosphate pathway_Homo sapiens_hsa000300.70125795
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70096314
94Chemokine signaling pathway_Homo sapiens_hsa040620.69299614
95Phenylalanine metabolism_Homo sapiens_hsa003600.66993711
96Synaptic vesicle cycle_Homo sapiens_hsa047210.66020968
97Shigellosis_Homo sapiens_hsa051310.65924709
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65339288
99Peroxisome_Homo sapiens_hsa041460.65028092
100HIF-1 signaling pathway_Homo sapiens_hsa040660.65023993
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64850926
102Lysosome_Homo sapiens_hsa041420.64738472
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64594288
104Legionellosis_Homo sapiens_hsa051340.64532330
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.64216065
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.63773914
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63765825
108Glioma_Homo sapiens_hsa052140.63761200
109Estrogen signaling pathway_Homo sapiens_hsa049150.63739224
110MAPK signaling pathway_Homo sapiens_hsa040100.63665428
111Gastric acid secretion_Homo sapiens_hsa049710.63440896
112AMPK signaling pathway_Homo sapiens_hsa041520.63383253
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62216804
114Inositol phosphate metabolism_Homo sapiens_hsa005620.62003863
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61595717
116Prolactin signaling pathway_Homo sapiens_hsa049170.61192805
117HTLV-I infection_Homo sapiens_hsa051660.60634047
118Prion diseases_Homo sapiens_hsa050200.60173026
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.58484988
120Glycerolipid metabolism_Homo sapiens_hsa005610.58092933
121Galactose metabolism_Homo sapiens_hsa000520.56898215
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.56276314
123Amoebiasis_Homo sapiens_hsa051460.55881722
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55437667
125Renin secretion_Homo sapiens_hsa049240.55234337
126African trypanosomiasis_Homo sapiens_hsa051430.52825334
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52745785
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52597887
129Dilated cardiomyopathy_Homo sapiens_hsa054140.52168554
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50683117
131T cell receptor signaling pathway_Homo sapiens_hsa046600.50514408
132Glucagon signaling pathway_Homo sapiens_hsa049220.50294755
133Dorso-ventral axis formation_Homo sapiens_hsa043200.50194975
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.48618316
135Chemical carcinogenesis_Homo sapiens_hsa052040.48574097
136Fatty acid biosynthesis_Homo sapiens_hsa000610.47515677
137Proteoglycans in cancer_Homo sapiens_hsa052050.47453009
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47191116
139Pancreatic cancer_Homo sapiens_hsa052120.47082611
140Bladder cancer_Homo sapiens_hsa052190.47068660
141GnRH signaling pathway_Homo sapiens_hsa049120.46889138
142Primary immunodeficiency_Homo sapiens_hsa053400.46615429
143Toxoplasmosis_Homo sapiens_hsa051450.44004802
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42826061
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.42583240
146cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41897340
147Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41617902
148Endocytosis_Homo sapiens_hsa041440.40127849
149Notch signaling pathway_Homo sapiens_hsa043300.39515408
150Endometrial cancer_Homo sapiens_hsa052130.39496309
151Maturity onset diabetes of the young_Homo sapiens_hsa049500.38225934
152Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37975396
153Arginine and proline metabolism_Homo sapiens_hsa003300.37837210

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