URM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.48418776
2central nervous system myelination (GO:0022010)7.48418776
3ribosomal small subunit assembly (GO:0000028)6.50535043
4protein localization to endoplasmic reticulum (GO:0070972)5.57690577
5axon ensheathment (GO:0008366)5.20992302
6ensheathment of neurons (GO:0007272)5.20992302
7modulation by virus of host process (GO:0019054)5.18581310
8myelination (GO:0042552)5.08012580
9modulation by symbiont of host cellular process (GO:0044068)4.68063819
10macromolecular complex disassembly (GO:0032984)4.61247004
11negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.54474764
12protein targeting to membrane (GO:0006612)4.31284752
13mitotic nuclear envelope reassembly (GO:0007084)4.24489367
14nuclear envelope reassembly (GO:0031468)4.24489367
15maturation of SSU-rRNA (GO:0030490)4.24323129
16deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.19423265
17establishment of apical/basal cell polarity (GO:0035089)4.16366902
18negative regulation of peptidyl-threonine phosphorylation (GO:0010801)4.14993714
19establishment of mitochondrion localization (GO:0051654)4.13685105
20Arp2/3 complex-mediated actin nucleation (GO:0034314)4.02944564
21myelin maintenance (GO:0043217)3.87637913
22polarized epithelial cell differentiation (GO:0030859)3.86855466
23apoptotic process involved in morphogenesis (GO:0060561)3.86657182
24viral transcription (GO:0019083)3.85164329
25transcription from mitochondrial promoter (GO:0006390)3.82841581
26poly(A)+ mRNA export from nucleus (GO:0016973)3.80050734
27negative regulation of GTP catabolic process (GO:0033125)3.76666492
28negative regulation of GTPase activity (GO:0034260)3.76666492
29formation of translation preinitiation complex (GO:0001731)3.73064287
30GDP-mannose metabolic process (GO:0019673)3.71603897
31peptidyl-arginine omega-N-methylation (GO:0035247)3.70339748
32astrocyte development (GO:0014002)3.69511320
33negative regulation of viral release from host cell (GO:1902187)3.68107856
34nuclear-transcribed mRNA catabolic process (GO:0000956)3.67760459
35protein maturation by protein folding (GO:0022417)3.65059540
36ribosomal small subunit biogenesis (GO:0042274)3.64667766
37negative regulation of Ras GTPase activity (GO:0034261)3.63859225
38translational termination (GO:0006415)3.60593432
39translation (GO:0006412)3.59013703
40cell migration in hindbrain (GO:0021535)3.58140729
41mRNA catabolic process (GO:0006402)3.51689611
42establishment of protein localization to mitochondrial membrane (GO:0090151)3.48428034
43establishment of monopolar cell polarity (GO:0061162)3.48420475
44establishment or maintenance of monopolar cell polarity (GO:0061339)3.48420475
45histone arginine methylation (GO:0034969)3.43506896
46amyloid precursor protein catabolic process (GO:0042987)3.42528687
47protein neddylation (GO:0045116)3.42323606
48ncRNA 3-end processing (GO:0043628)3.40569380
49DNA deamination (GO:0045006)3.32907850
50regulation of gene silencing by RNA (GO:0060966)3.32183445
51regulation of posttranscriptional gene silencing (GO:0060147)3.32183445
52regulation of gene silencing by miRNA (GO:0060964)3.32183445
53modulation by virus of host morphology or physiology (GO:0019048)3.27837406
54negative regulation of nucleotide catabolic process (GO:0030812)3.27786667
55RNA catabolic process (GO:0006401)3.23490779
56negative regulation of JAK-STAT cascade (GO:0046426)3.22433292
57fatty acid elongation (GO:0030497)3.19576647
58enteric nervous system development (GO:0048484)3.16800935
59protein localization to endosome (GO:0036010)3.16141978
60translational initiation (GO:0006413)3.14673190
61apoptotic process involved in development (GO:1902742)3.14409693
62pentose metabolic process (GO:0019321)3.12666955
63establishment of protein localization to membrane (GO:0090150)3.12239721
64negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.10625036
65actin nucleation (GO:0045010)3.09794526
66heterochromatin organization (GO:0070828)3.09281614
67negative regulation of purine nucleotide catabolic process (GO:0033122)3.08868680
68long-chain fatty acid biosynthetic process (GO:0042759)3.08638635
69regulation of response to osmotic stress (GO:0047484)3.06881564
70pyrimidine nucleoside salvage (GO:0043097)3.05632157
71pyrimidine-containing compound salvage (GO:0008655)3.05632157
72myelination in peripheral nervous system (GO:0022011)3.05522927
73peripheral nervous system axon ensheathment (GO:0032292)3.05522927
74establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.04730928
75mitochondrion transport along microtubule (GO:0047497)3.04730928
76translational elongation (GO:0006414)3.04288186
77maternal placenta development (GO:0001893)3.04232310
78UV protection (GO:0009650)3.04018454
79endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.03549055
80pentose-phosphate shunt (GO:0006098)3.02681703
81NIK/NF-kappaB signaling (GO:0038061)3.02644256
82energy coupled proton transport, down electrochemical gradient (GO:0015985)3.01412795
83ATP synthesis coupled proton transport (GO:0015986)3.01412795
84creatine metabolic process (GO:0006600)2.98736842
85detection of temperature stimulus (GO:0016048)2.97147996
86nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.94791597
87regulation of mammary gland epithelial cell proliferation (GO:0033599)2.92735483
88ribosomal large subunit biogenesis (GO:0042273)2.92114621
89detection of temperature stimulus involved in sensory perception (GO:0050961)2.92023127
90detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.92023127
91regulation of viral release from host cell (GO:1902186)2.90822581
92regulation of early endosome to late endosome transport (GO:2000641)2.90523994
93negative regulation of focal adhesion assembly (GO:0051895)2.88418277
94negative regulation of cell junction assembly (GO:1901889)2.88418277
95negative regulation of adherens junction organization (GO:1903392)2.88418277
96cellular protein complex disassembly (GO:0043624)2.87582765
97membrane tubulation (GO:0097320)2.86478255
98asymmetric protein localization (GO:0008105)2.85896457
99viral life cycle (GO:0019058)2.85650005
100regulation of collateral sprouting (GO:0048670)2.84836468
101mitochondrial DNA metabolic process (GO:0032042)2.83112577
102peptidyl-arginine methylation (GO:0018216)2.82728101
103peptidyl-arginine N-methylation (GO:0035246)2.82728101
104proline biosynthetic process (GO:0006561)2.81095326
105aerobic respiration (GO:0009060)2.78979065
106oxidative phosphorylation (GO:0006119)2.77157914
107negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.76676655
108amino acid import (GO:0043090)2.76170315
109protein targeting to ER (GO:0045047)2.73481820
110activation of MAPKKK activity (GO:0000185)2.72967607
111L-serine metabolic process (GO:0006563)2.72313639
112ribonucleoprotein complex biogenesis (GO:0022613)2.70735274
113cotranslational protein targeting to membrane (GO:0006613)2.70132773
114intracellular estrogen receptor signaling pathway (GO:0030520)2.68934785
115response to peptidoglycan (GO:0032494)2.68916503
116adhesion of symbiont to host cell (GO:0044650)2.68831379
117virion attachment to host cell (GO:0019062)2.68831379
118oligodendrocyte differentiation (GO:0048709)2.68805980
119mitochondrial calcium ion transport (GO:0006851)2.67668819
120cellular component biogenesis (GO:0044085)2.67259637
121establishment of protein localization to endoplasmic reticulum (GO:0072599)2.66942822
122SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.66634440
123regulation of translational fidelity (GO:0006450)2.66455191
124regulation of translational elongation (GO:0006448)2.66332916
125mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.64446972
126protein targeting (GO:0006605)2.64110602
127COPI coating of Golgi vesicle (GO:0048205)2.63283202
128Golgi transport vesicle coating (GO:0048200)2.63283202
129barbed-end actin filament capping (GO:0051016)2.62894855
130negative regulation of neurotransmitter secretion (GO:0046929)2.62082577
131negative regulation of macroautophagy (GO:0016242)2.59937727
132establishment of mitotic spindle localization (GO:0040001)2.59912611
133rRNA processing (GO:0006364)2.59402624
134spinal cord development (GO:0021510)2.58441582
135establishment or maintenance of apical/basal cell polarity (GO:0035088)2.58280924
136establishment or maintenance of bipolar cell polarity (GO:0061245)2.58280924
137nucleobase-containing small molecule interconversion (GO:0015949)2.57322647
138branching involved in mammary gland duct morphogenesis (GO:0060444)2.57260326
139pseudouridine synthesis (GO:0001522)2.56738540
140neurotransmitter uptake (GO:0001504)2.56421180
141positive regulation of developmental pigmentation (GO:0048087)2.55555184
142regulation of translational termination (GO:0006449)2.54393459
143protein complex disassembly (GO:0043241)2.53722270
144negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.53433312
145regulation of hippo signaling (GO:0035330)2.53307210
146mitochondrial fusion (GO:0008053)2.52735287
147protein retention in ER lumen (GO:0006621)2.52732521
148short-term memory (GO:0007614)2.52687687
149spliceosomal tri-snRNP complex assembly (GO:0000244)2.52604734
150NADPH regeneration (GO:0006740)2.48108872
151neutrophil activation involved in immune response (GO:0002283)2.46997922
152microtubule severing (GO:0051013)2.45228049
153protein localization to membrane (GO:0072657)2.42404559
154ribosome biogenesis (GO:0042254)2.40976610
155deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.40282667
156mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.39554288
157negative regulation of erythrocyte differentiation (GO:0045647)2.39552045
158heme biosynthetic process (GO:0006783)2.38476844
159rRNA modification (GO:0000154)2.38382606
160purine deoxyribonucleotide catabolic process (GO:0009155)2.37781375
161respiratory electron transport chain (GO:0022904)2.37587675
162myeloid cell homeostasis (GO:0002262)2.34966932
163glucose catabolic process (GO:0006007)2.34078825
164folic acid metabolic process (GO:0046655)2.33246876
165positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.32366686
166negative regulation of cell size (GO:0045792)2.30916193
167CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.30840699
168negative regulation of phagocytosis (GO:0050765)2.30282127
169NADH metabolic process (GO:0006734)2.29261387
170protein insertion into membrane (GO:0051205)2.28485740
171electron transport chain (GO:0022900)2.27425251
172antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.27278533
173histone H2B ubiquitination (GO:0033523)2.26761956
174protein targeting to mitochondrion (GO:0006626)2.26556709
175purine deoxyribonucleotide metabolic process (GO:0009151)2.26339640
176purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.25778714
177T cell apoptotic process (GO:0070231)2.25747543

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.90495179
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.90495179
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.90495179
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.39249866
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.04864834
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.84768421
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.51547356
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.46583118
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.38280493
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.29915149
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.27304552
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.23377901
13* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.21252773
14KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.18109832
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13153644
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.04363563
17VDR_21846776_ChIP-Seq_THP-1_Human1.96357540
18MYC_18358816_ChIP-ChIP_MESCs_Mouse1.92714016
19SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.91626285
20THAP11_20581084_ChIP-Seq_MESCs_Mouse1.90995728
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89963248
22* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.86880450
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.86778446
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86366916
25NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.85870817
26LXR_22292898_ChIP-Seq_THP-1_Human1.85435554
27ZFP281_18757296_ChIP-ChIP_E14_Mouse1.84402582
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.83640930
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.82499650
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.78152915
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67710393
32* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65756579
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65301185
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.65225504
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63662502
36XRN2_22483619_ChIP-Seq_HELA_Human1.63560357
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.63390526
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59332966
39NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.58693245
40* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.58658810
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57204367
42RACK7_27058665_Chip-Seq_MCF-7_Human1.56531638
43KDM2B_26808549_Chip-Seq_DND41_Human1.55453009
44POU5F1_16518401_ChIP-PET_MESCs_Mouse1.54764044
45ELF1_20517297_ChIP-Seq_JURKAT_Human1.53480916
46* YY1_21170310_ChIP-Seq_MESCs_Mouse1.52098547
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51623908
48* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.51014224
49KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.50302356
50* YY1_22570637_ChIP-Seq_MALME-3M_Human1.49009730
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48053461
52CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47919264
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45287151
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.45076531
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44319149
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44162293
57ZNF263_19887448_ChIP-Seq_K562_Human1.43835726
58* GABP_19822575_ChIP-Seq_HepG2_Human1.40615781
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.38104464
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37460515
61* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.37400835
62MYC_22102868_ChIP-Seq_BL_Human1.37164314
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.37082603
64* FOXP1_21924763_ChIP-Seq_HESCs_Human1.36566281
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.35978272
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34505085
67BCL6_27268052_Chip-Seq_Bcells_Human1.34163583
68* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33589681
69KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32655138
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.31606050
71OCT4_18692474_ChIP-Seq_MEFs_Mouse1.31450152
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31340105
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31113174
74* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.30880298
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.29671178
76CTCF_26484167_Chip-Seq_Bcells_Mouse1.29319929
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28102171
78SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.27979854
79MAF_26560356_Chip-Seq_TH1_Human1.27623195
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27297129
81UTX_26944678_Chip-Seq_JUKART_Human1.26392736
82* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.26179889
83DCP1A_22483619_ChIP-Seq_HELA_Human1.25903073
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25675459
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24834638
86* P68_20966046_ChIP-Seq_HELA_Human1.24270325
87TP53_22127205_ChIP-Seq_IMR90_Human1.24102073
88NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.23708750
89VDR_24763502_ChIP-Seq_THP-1_Human1.23224065
90* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.23181371
91SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23172077
92STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22689874
93P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22509155
94NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21788272
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21509678
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21208113
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20725177
98* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.19627396
99CTCF_18555785_ChIP-Seq_MESCs_Mouse1.18908868
100FOXM1_23109430_ChIP-Seq_U2OS_Human1.18448438
101SA1_27219007_Chip-Seq_ERYTHROID_Human1.18391083
102ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18197882
103RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18106205
104* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17821113
105TP63_17297297_ChIP-ChIP_HaCaT_Human1.17197828
106TRIM28_21343339_ChIP-Seq_HEK293_Human1.16956739
107SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15949553
108BCOR_27268052_Chip-Seq_Bcells_Human1.15922672
109KDM5A_27292631_Chip-Seq_BREAST_Human1.14764120
110UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14653847
111GABP_17652178_ChIP-ChIP_JURKAT_Human1.13149348
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12469344
113SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12199685
114TTF2_22483619_ChIP-Seq_HELA_Human1.12161093
115PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11131434
116SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09378280
117* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.09045140
118CREB1_26743006_Chip-Seq_LNCaP_Human1.07456067
119KDM2B_26808549_Chip-Seq_K562_Human1.07417689
120MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07030415
121TCF7_22412390_ChIP-Seq_EML_Mouse1.06606688
122CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.06103627
123E2F7_22180533_ChIP-Seq_HELA_Human1.05863584
124MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05540433
125E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05487864
126E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05368381
127ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04773712
128* SA1_27219007_Chip-Seq_Bcells_Human1.04400654
129MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04264723
130PHF8_20622854_ChIP-Seq_HELA_Human1.04160877
131RARA_24833708_ChIP-Seq_LIVER_Mouse1.03720673
132SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02758178
133PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02751857
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01742911
135MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01198898
136MAF_26560356_Chip-Seq_TH2_Human1.00905785
137* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00104657
138CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99856301
139CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99792297
140TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99365043
141CTCF_21964334_Chip-Seq_Bcells_Human0.98181774
142SMC4_20622854_ChIP-Seq_HELA_Human0.96731694
143PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.95791063
144E2F1_20622854_ChIP-Seq_HELA_Human0.95450379

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.49422312
2MP0003136_yellow_coat_color3.41467929
3MP0000920_abnormal_myelination3.00222930
4MP0003436_decreased_susceptibility_to2.95464036
5MP0002653_abnormal_ependyma_morphology2.82177739
6MP0009333_abnormal_splenocyte_physiolog2.63819425
7MP0010030_abnormal_orbit_morphology2.59050919
8MP0005451_abnormal_body_composition2.46094025
9MP0005171_absent_coat_pigmentation2.41041815
10MP0008057_abnormal_DNA_replication2.39935745
11MP0005623_abnormal_meninges_morphology2.36831791
12MP0004185_abnormal_adipocyte_glucose2.18657801
13MP0002877_abnormal_melanocyte_morpholog2.03145136
14MP0009840_abnormal_foam_cell2.02910254
15MP0005671_abnormal_response_to1.95997736
16MP0004133_heterotaxia1.89837289
17MP0001849_ear_inflammation1.89428896
18MP0003283_abnormal_digestive_organ1.87637522
19MP0000762_abnormal_tongue_morphology1.85921335
20MP0008932_abnormal_embryonic_tissue1.85070235
21MP0003705_abnormal_hypodermis_morpholog1.80449576
22MP0000343_altered_response_to1.80221719
23MP0003634_abnormal_glial_cell1.79868492
24MP0004142_abnormal_muscle_tone1.75377945
25MP0003806_abnormal_nucleotide_metabolis1.71714220
26MP0000604_amyloidosis1.70321139
27MP0003950_abnormal_plasma_membrane1.62334250
28MP0004145_abnormal_muscle_electrophysio1.60917408
29MP0004742_abnormal_vestibular_system1.60073002
30MP0004957_abnormal_blastocyst_morpholog1.59472386
31MP0003938_abnormal_ear_development1.59147395
32MP0009278_abnormal_bone_marrow1.57545638
33MP0000747_muscle_weakness1.54251858
34MP0000490_abnormal_crypts_of1.53279949
35MP0000462_abnormal_digestive_system1.51858081
36MP0002148_abnormal_hypersensitivity_rea1.51704629
37MP0004885_abnormal_endolymph1.51395672
38MP0003075_altered_response_to1.50148308
39MP0005330_cardiomyopathy1.49792718
40MP0005025_abnormal_response_to1.49341416
41MP0000778_abnormal_nervous_system1.49053421
42MP0000733_abnormal_muscle_development1.45938452
43MP0002089_abnormal_postnatal_growth/wei1.45623974
44MP0006036_abnormal_mitochondrial_physio1.45159878
45MP0001533_abnormal_skeleton_physiology1.45101690
46MP0004233_abnormal_muscle_weight1.44196017
47MP0000858_altered_metastatic_potential1.42580195
48MP0001881_abnormal_mammary_gland1.40792544
49MP0003303_peritoneal_inflammation1.40557244
50MP0003186_abnormal_redox_activity1.40440920
51MP0008438_abnormal_cutaneous_collagen1.40382808
52MP0001348_abnormal_lacrimal_gland1.40131251
53MP0001730_embryonic_growth_arrest1.39990117
54MP0000467_abnormal_esophagus_morphology1.39621257
55MP0002085_abnormal_embryonic_tissue1.38360310
56MP0000955_abnormal_spinal_cord1.33697471
57MP0005000_abnormal_immune_tolerance1.33351087
58MP0005464_abnormal_platelet_physiology1.30848475
59MP0002733_abnormal_thermal_nociception1.30379524
60MP0001485_abnormal_pinna_reflex1.30118841
61MP0002163_abnormal_gland_morphology1.29795928
62MP0005387_immune_system_phenotype1.28483622
63MP0001790_abnormal_immune_system1.28483622
64MP0002111_abnormal_tail_morphology1.27820883
65MP0002419_abnormal_innate_immunity1.27137645
66MP0001293_anophthalmia1.27014378
67MP0005058_abnormal_lysosome_morphology1.26785563
68MP0000685_abnormal_immune_system1.24901850
69MP0000428_abnormal_craniofacial_morphol1.23580691
70MP0002084_abnormal_developmental_patter1.17794752
71MP0003119_abnormal_digestive_system1.17525989
72MP0002132_abnormal_respiratory_system1.17425771
73MP0003137_abnormal_impulse_conducting1.17418360
74MP0001853_heart_inflammation1.16909457
75MP0004947_skin_inflammation1.16409392
76MP0005666_abnormal_adipose_tissue1.16196218
77MP0003755_abnormal_palate_morphology1.16001062
78MP0004858_abnormal_nervous_system1.15584904
79MP0003111_abnormal_nucleus_morphology1.14556038
80MP0000383_abnormal_hair_follicle1.14428269
81MP0003172_abnormal_lysosome_physiology1.13924437
82MP0006035_abnormal_mitochondrial_morpho1.13397782
83MP0003385_abnormal_body_wall1.12484361
84MP0003329_amyloid_beta_deposits1.12455139
85MP0005670_abnormal_white_adipose1.12438847
86MP0002751_abnormal_autonomic_nervous1.12091901
87MP0004381_abnormal_hair_follicle1.11409102
88MP0003123_paternal_imprinting1.10230474
89MP0002723_abnormal_immune_serum1.10113126
90MP0003221_abnormal_cardiomyocyte_apopto1.09697407
91MP0003453_abnormal_keratinocyte_physiol1.09374553
92MP0003690_abnormal_glial_cell1.09086235
93MP0005394_taste/olfaction_phenotype1.09037073
94MP0005499_abnormal_olfactory_system1.09037073
95MP0005380_embryogenesis_phenotype1.08769542
96MP0001672_abnormal_embryogenesis/_devel1.08769542
97MP0000015_abnormal_ear_pigmentation1.08763018
98MP0002998_abnormal_bone_remodeling1.08716913
99MP0001819_abnormal_immune_cell1.08001322
100MP0002420_abnormal_adaptive_immunity1.07369685
101MP0002064_seizures1.06517014
102MP0003937_abnormal_limbs/digits/tail_de1.06260166
103MP0009785_altered_susceptibility_to1.06022980
104MP0003763_abnormal_thymus_physiology1.05519372
105MP0005360_urolithiasis1.04781862
106MP0000759_abnormal_skeletal_muscle1.04444243
107MP0003861_abnormal_nervous_system1.04075750
108MP0005257_abnormal_intraocular_pressure1.03825731
109MP0008260_abnormal_autophagy1.03586829
110MP0002452_abnormal_antigen_presenting1.02741408
111MP0001697_abnormal_embryo_size1.01703292
112MP0002229_neurodegeneration1.01371850
113MP0002932_abnormal_joint_morphology1.00594687
114MP0004270_analgesia1.00561322
115MP0001970_abnormal_pain_threshold1.00356722
116MP0002114_abnormal_axial_skeleton1.00047255
117MP0002882_abnormal_neuron_morphology0.99677029
118MP0000751_myopathy0.99361822
119MP0000350_abnormal_cell_proliferation0.98550631
120MP0000750_abnormal_muscle_regeneration0.98414129
121MP0002272_abnormal_nervous_system0.97160931
122MP0005075_abnormal_melanosome_morpholog0.97087215
123MP0000678_abnormal_parathyroid_gland0.97076128
124MP0003632_abnormal_nervous_system0.96924374
125MP0002269_muscular_atrophy0.96729839
126MP0002752_abnormal_somatic_nervous0.95856068
127MP0008789_abnormal_olfactory_epithelium0.95006961
128MP0002429_abnormal_blood_cell0.94771949
129MP0002080_prenatal_lethality0.94695573
130MP0000749_muscle_degeneration0.93987243
131MP0002398_abnormal_bone_marrow0.93612389
132MP0000579_abnormal_nail_morphology0.93311347
133MP0005023_abnormal_wound_healing0.93284131
134MP0009250_abnormal_appendicular_skeleto0.93107598
135MP0005397_hematopoietic_system_phenotyp0.92523364
136MP0001545_abnormal_hematopoietic_system0.92523364
137MP0005390_skeleton_phenotype0.92044812
138MP0004197_abnormal_fetal_growth/weight/0.91922397
139MP0005375_adipose_tissue_phenotype0.91408278
140MP0010307_abnormal_tumor_latency0.90875026
141MP0005501_abnormal_skin_physiology0.90208404
142MP0002066_abnormal_motor_capabilities/c0.89694311
143MP0001529_abnormal_vocalization0.89494818
144MP0000537_abnormal_urethra_morphology0.88797100
145MP0005508_abnormal_skeleton_morphology0.88702369
146MP0002092_abnormal_eye_morphology0.88563492
147MP0000534_abnormal_ureter_morphology0.88393285
148MP0002249_abnormal_larynx_morphology0.87773186
149MP0002796_impaired_skin_barrier0.86330766
150MP0000716_abnormal_immune_system0.86233823
151MP0002152_abnormal_brain_morphology0.86219375
152MP0001727_abnormal_embryo_implantation0.85841429
153MP0010678_abnormal_skin_adnexa0.84221959
154MP0003077_abnormal_cell_cycle0.84018612
155MP0003935_abnormal_craniofacial_develop0.83662044
156MP0001835_abnormal_antigen_presentation0.83323020
157MP0000681_abnormal_thyroid_gland0.82193322
158MP0008469_abnormal_protein_level0.82040142
159MP0003984_embryonic_growth_retardation0.81856382
160MP0009053_abnormal_anal_canal0.81784501
161MP0003191_abnormal_cellular_cholesterol0.81692687
162MP0005584_abnormal_enzyme/coenzyme_acti0.81519712
163MP0003693_abnormal_embryo_hatching0.80774550
164MP0002088_abnormal_embryonic_growth/wei0.80491736
165MP0005319_abnormal_enzyme/_coenzyme0.80280790
166MP0001340_abnormal_eyelid_morphology0.80263750
167MP0002116_abnormal_craniofacial_bone0.80130004
168MP0003300_gastrointestinal_ulcer0.78730417
169MP0001915_intracranial_hemorrhage0.78350024
170MP0001845_abnormal_inflammatory_respons0.77937863
171MP0000313_abnormal_cell_death0.76289157
172MP0001800_abnormal_humoral_immune0.75715657
173MP0002722_abnormal_immune_system0.75414226
174MP0003448_altered_tumor_morphology0.74945320
175MP0004510_myositis0.74046049
176MP0001663_abnormal_digestive_system0.72730469
177MP0000003_abnormal_adipose_tissue0.72432907
178MP0001186_pigmentation_phenotype0.72263986

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)5.68024831
2Concave nail (HP:0001598)5.14087215
3Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.41010273
4Axonal loss (HP:0003447)4.14923713
5Sensory axonal neuropathy (HP:0003390)4.07845631
6Vertebral compression fractures (HP:0002953)4.06271013
7Ragged-red muscle fibers (HP:0003200)3.67052018
8Premature rupture of membranes (HP:0001788)3.66077338
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.55889459
10Degeneration of the lateral corticospinal tracts (HP:0002314)3.55889459
11Reticulocytopenia (HP:0001896)3.49415324
12Rib fusion (HP:0000902)3.43996676
13Hypertensive crisis (HP:0100735)3.41540894
14Progressive external ophthalmoplegia (HP:0000590)3.40559252
15Distal lower limb muscle weakness (HP:0009053)3.37676621
16Upper motor neuron abnormality (HP:0002127)3.29203706
17Abnormality of cells of the erythroid lineage (HP:0012130)3.23062496
18Achilles tendon contracture (HP:0001771)3.22849811
19Coronal craniosynostosis (HP:0004440)3.20654351
20Premature skin wrinkling (HP:0100678)3.15611443
21Abnormality of the corticospinal tract (HP:0002492)3.15057904
22Alacrima (HP:0000522)3.09943300
23Ulnar bowing (HP:0003031)3.02385868
24Pallor (HP:0000980)3.01717513
25Myopathic facies (HP:0002058)3.00643167
26Severe visual impairment (HP:0001141)2.96920804
27Macrocytic anemia (HP:0001972)2.95758488
28Abnormal number of erythroid precursors (HP:0012131)2.93277019
29Hyperacusis (HP:0010780)2.91294653
30Distal lower limb amyotrophy (HP:0008944)2.90316017
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.81021952
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.81021952
33Neurofibrillary tangles (HP:0002185)2.79880625
34Abnormality of the Achilles tendon (HP:0005109)2.73752014
35Esophageal atresia (HP:0002032)2.71491206
36Turricephaly (HP:0000262)2.70950863
37Peripheral hypomyelination (HP:0007182)2.68346677
38Protrusio acetabuli (HP:0003179)2.65416011
39Rectal fistula (HP:0100590)2.63924792
40Rectovaginal fistula (HP:0000143)2.63924792
41Abnormal hemoglobin (HP:0011902)2.61654345
42Abnormality of the umbilical cord (HP:0010881)2.58022883
43CNS hypomyelination (HP:0003429)2.50299109
44Personality changes (HP:0000751)2.49297616
45Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.48914840
46Parakeratosis (HP:0001036)2.46143515
47Abnormality of glycolipid metabolism (HP:0010969)2.39637565
48Abnormality of liposaccharide metabolism (HP:0010968)2.39637565
49Abnormality of glycosphingolipid metabolism (HP:0004343)2.39637565
50Supranuclear gaze palsy (HP:0000605)2.39532117
51Abnormality of the astrocytes (HP:0100707)2.38500043
52Astrocytoma (HP:0009592)2.38500043
53Agnosia (HP:0010524)2.37655573
54Abnormality of reticulocytes (HP:0004312)2.37373587
55Large earlobe (HP:0009748)2.35522116
56Abnormality of the labia minora (HP:0012880)2.31153251
57Generalized amyotrophy (HP:0003700)2.28419510
58Progressive neurologic deterioration (HP:0002344)2.27894275
59Decreased lacrimation (HP:0000633)2.26913486
60Diaphragmatic weakness (HP:0009113)2.25157720
61Myokymia (HP:0002411)2.25025470
62Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23859130
63Cerebral inclusion bodies (HP:0100314)2.23471158
64Absent radius (HP:0003974)2.23453266
65Absent septum pellucidum (HP:0001331)2.21488033
66Fused cervical vertebrae (HP:0002949)2.20482953
67Centrally nucleated skeletal muscle fibers (HP:0003687)2.19659532
68Muscle fiber splitting (HP:0003555)2.18287357
69Long palpebral fissure (HP:0000637)2.18217312
70Aplasia involving forearm bones (HP:0009822)2.14253317
71Absent forearm bone (HP:0003953)2.14253317
72Aplasia/hypoplasia of the humerus (HP:0006507)2.13901534
73Clumsiness (HP:0002312)2.13663367
74Spastic gait (HP:0002064)2.13144326
75Insomnia (HP:0100785)2.12048158
76Progressive muscle weakness (HP:0003323)2.11801631
77Hypoplastic pelvis (HP:0008839)2.11588100
78Round ear (HP:0100830)2.10771032
79Neck muscle weakness (HP:0000467)2.10513250
80Anteriorly placed anus (HP:0001545)2.10448555
81Onion bulb formation (HP:0003383)2.10247689
82Increased muscle lipid content (HP:0009058)2.10143544
83Generalized hypotonia (HP:0001290)2.09945548
84Abnormal gallbladder physiology (HP:0012438)2.09619157
85Cholecystitis (HP:0001082)2.09619157
86Disinhibition (HP:0000734)2.09039124
87Septo-optic dysplasia (HP:0100842)2.06646474
88Vaginal fistula (HP:0004320)2.06316086
89Ependymoma (HP:0002888)2.05867008
90Difficulty climbing stairs (HP:0003551)2.05692297
91Abnormality of the septum pellucidum (HP:0007375)2.05460584
92Intestinal fistula (HP:0100819)2.05005827
93Rough bone trabeculation (HP:0100670)2.04959398
94Petechiae (HP:0000967)2.04958137
95Aplasia/Hypoplasia involving the musculature (HP:0001460)2.04015572
96Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.03799516
97Insidious onset (HP:0003587)2.03600386
98Termporal pattern (HP:0011008)2.03600386
99Increased intramyocellular lipid droplets (HP:0012240)2.03018049
100Purpura (HP:0000979)2.01574861
101Obstructive sleep apnea (HP:0002870)2.01559773
102Annular pancreas (HP:0001734)2.00829134
103Abnormality of aromatic amino acid family metabolism (HP:0004338)2.00193560
104Congenital ichthyosiform erythroderma (HP:0007431)1.98853105
105Stridor (HP:0010307)1.98739566
106Trismus (HP:0000211)1.97398558
107Athetosis (HP:0002305)1.96758628
108Hypokinesia (HP:0002375)1.96504025
109Difficulty running (HP:0009046)1.95857036
110Abnormal mitochondria in muscle tissue (HP:0008316)1.94965857
111Hyporeflexia of lower limbs (HP:0002600)1.94791292
112Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93896272
113Abnormality of the salivary glands (HP:0010286)1.92413995
114Abnormal umbilical cord blood vessels (HP:0011403)1.91833542
115Single umbilical artery (HP:0001195)1.91833542
116Abnormality of the fetal cardiovascular system (HP:0010948)1.91833542
117Abnormal auditory evoked potentials (HP:0006958)1.90699238
118Vertebral fusion (HP:0002948)1.88846215
119Pathologic fracture (HP:0002756)1.88580658
120Increased connective tissue (HP:0009025)1.88436463
121Hepatosplenomegaly (HP:0001433)1.87911823
122Spinal rigidity (HP:0003306)1.86170768
123Opisthotonus (HP:0002179)1.84777205
124Aplasia of the musculature (HP:0100854)1.84631752
125Reticulocytosis (HP:0001923)1.84301185
126Dicarboxylic aciduria (HP:0003215)1.84260536
127Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84260536
128Increased IgM level (HP:0003496)1.83265327
129Multiple enchondromatosis (HP:0005701)1.83176310
130Chronic obstructive pulmonary disease (HP:0006510)1.83060873
131Obstructive lung disease (HP:0006536)1.83060873
132Akinesia (HP:0002304)1.82238295
133Polygenic inheritance (HP:0010982)1.80888252
134Pterygium (HP:0001059)1.80459502
135Short humerus (HP:0005792)1.79455663
136Foot dorsiflexor weakness (HP:0009027)1.79094440
137Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.78543814
138Microvesicular hepatic steatosis (HP:0001414)1.78474209
139Broad face (HP:0000283)1.77800717
140Rhabdomyolysis (HP:0003201)1.76983555
141Biconcave vertebral bodies (HP:0004586)1.76434156
142Truncus arteriosus (HP:0001660)1.76251111
143Prominent occiput (HP:0000269)1.76015764
144Microretrognathia (HP:0000308)1.75887717
145Partial duplication of the phalanx of hand (HP:0009999)1.75445353
146Upper limb amyotrophy (HP:0009129)1.74585294
147Distal upper limb amyotrophy (HP:0007149)1.74585294
148Emotional lability (HP:0000712)1.73311784
149Abnormal number of incisors (HP:0011064)1.73292057
150Spastic paraparesis (HP:0002313)1.73054418
151Abnormality of the motor neurons (HP:0002450)1.73004564
152Abnormal neuron morphology (HP:0012757)1.73004564
153Reduced subcutaneous adipose tissue (HP:0003758)1.72531978
154Breast hypoplasia (HP:0003187)1.70941428
155Bowel incontinence (HP:0002607)1.70908164
156Recurrent abscess formation (HP:0002722)1.70758080
157Adrenal hypoplasia (HP:0000835)1.70378435
158Cellulitis (HP:0100658)1.69916368
159Congenital hip dislocation (HP:0001374)1.69864789
160Neuronal loss in central nervous system (HP:0002529)1.69124137
161Vacuolated lymphocytes (HP:0001922)1.69062155
162J-shaped sella turcica (HP:0002680)1.69021537
163Partial agenesis of the corpus callosum (HP:0001338)1.68529805
164Hepatocellular necrosis (HP:0001404)1.68320504
165Recurrent bacterial skin infections (HP:0005406)1.67857054
166Ankle clonus (HP:0011448)1.67776910
167Testicular atrophy (HP:0000029)1.67768031
168Joint stiffness (HP:0001387)1.67211227
169Gastrointestinal stroma tumor (HP:0100723)1.67126900
170Abnormal large intestine physiology (HP:0012700)1.66832166
171Hyperthyroidism (HP:0000836)1.66469151
172Neoplasm of striated muscle (HP:0009728)1.66185091
173Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.66169063
174Dysostosis multiplex (HP:0000943)1.65747044
175Muscle fibrillation (HP:0010546)1.65606181
176Redundant skin (HP:0001582)1.65497088
177Relative macrocephaly (HP:0004482)1.65281922
178Bulbar palsy (HP:0001283)1.65190378
179Abnormal trabecular bone morphology (HP:0100671)1.65045213
180Seborrheic dermatitis (HP:0001051)1.64446957
181Broad distal phalanx of finger (HP:0009836)1.63627696
182Paraparesis (HP:0002385)1.63462948
183Abnormality of the foot musculature (HP:0001436)1.63234438
184Hepatic necrosis (HP:0002605)1.63009047
185Bone pain (HP:0002653)1.62903166
186Asplenia (HP:0001746)1.62766086
187Abnormality of macrophages (HP:0004311)1.61975080
188Deep palmar crease (HP:0006191)1.61491430
189Thrombocytosis (HP:0001894)1.61272100

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.59030171
2ICK3.74428183
3VRK23.63858623
4BCKDK3.57083253
5TYRO33.40313267
6SMG13.35588970
7STK393.30278631
8PRPF4B2.95353328
9UHMK12.80101714
10IRAK32.75085428
11DDR22.53755815
12ERN12.41283445
13TESK12.37432795
14NME12.20103381
15TESK22.19170046
16CDK192.12890262
17EPHB12.02377309
18BMX2.02214598
19SCYL21.99642514
20NME21.97869813
21OXSR11.94120656
22TAOK21.92904915
23FGR1.89814372
24LIMK11.76247865
25TRIB31.75573571
26ALK1.74526041
27BUB11.70012665
28MAP3K111.66371543
29CDK121.65317118
30SIK11.64946289
31MAP4K11.62383061
32PKN11.59183353
33PRKD21.57426866
34MARK21.46742765
35MET1.45032447
36EIF2AK11.44986621
37EEF2K1.44112794
38PHKG21.43237191
39PHKG11.43237191
40STK161.42741463
41DAPK31.38319431
42IRAK41.37715938
43ARAF1.37674018
44KDR1.32480947
45PINK11.30634432
46PIM21.29561001
47NTRK11.29391377
48WNK11.27799845
49PDGFRA1.24286018
50PAK61.22303562
51TBK11.21264400
52CSK1.19417813
53MAP2K31.15625064
54PAK41.15377012
55RPS6KB21.13786894
56WNK41.12829250
57LATS21.11793715
58ILK1.06206185
59CLK11.06173488
60ROCK21.03974576
61CDK71.03120298
62MAPKAPK31.01630250
63ABL20.96785704
64DMPK0.94632126
65MATK0.94457679
66GRK50.94277275
67CDK140.93497934
68PAK10.92511288
69MAP2K20.90581892
70MAPK150.89478837
71BRAF0.86979834
72CASK0.86600484
73EPHA20.82495027
74CDK150.80771274
75NEK10.80744098
76CDK11A0.79313488
77AURKA0.76966480
78DYRK1B0.76645527
79GSK3A0.76629330
80EPHB20.76183644
81PRKD10.72674436
82CAMK2B0.72221408
83PAK20.72220415
84PASK0.72133732
85SRPK10.71808425
86CDK180.69740619
87TTN0.69600123
88CSNK1G30.69122565
89FGFR20.68300234
90CDK80.67123716
91PTK60.66605517
92PKN20.66216841
93BRSK10.66047433
94TAOK10.63680394
95MAP3K10.61702207
96MOS0.60420918
97PDGFRB0.58876857
98HIPK20.58706417
99LMTK20.57942734
100CDK40.57684844
101CAMK2D0.57344582
102DAPK10.56692776
103MAPK110.56298732
104MKNK20.55256256
105FES0.54681454
106ZAP700.53121000
107MTOR0.52390377
108PRKG20.52149983
109DYRK20.51546142
110NEK20.51409278
111RIPK40.50961772
112CSNK1E0.50957410
113DYRK30.49837276
114FGFR40.48950157
115CAMK2G0.48861762
116PNCK0.47660064
117MAP3K100.47402000
118PDPK10.46691765
119CSNK1G10.46618796
120LRRK20.45973879
121MAPKAPK50.44554174
122IRAK20.44437418
123RPS6KA20.44235296
124MST40.43430498
125PLK10.43174258
126STK110.41593675
127MAP3K80.41050355
128TYK20.40332772
129CSNK1A1L0.38962987
130CSNK1D0.38657429
131CDK20.37925316
132CHEK20.37312536
133MAPKAPK20.37257483
134RPS6KC10.36237583
135RPS6KL10.36237583
136CSNK2A20.35717559
137IKBKB0.35651221
138GRK60.35566280
139INSR0.35172675
140CHEK10.34547333
141MAPK120.34128669
142MAPK100.33540308
143JAK30.33335092
144VRK10.32483697
145PRKCI0.31757772
146MAP3K60.31635550
147CAMKK10.31588121
148SYK0.31519458
149RPS6KA60.31081015
150CDC42BPA0.30776966
151AKT20.30236022
152CAMK2A0.29353347
153AURKB0.29235739
154RIPK10.28798651
155PBK0.28597592
156TTK0.27554162

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.93852102
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.92780859
3Vitamin B6 metabolism_Homo sapiens_hsa007503.35396550
4* Sulfur relay system_Homo sapiens_hsa041222.85981059
5Other glycan degradation_Homo sapiens_hsa005112.82502856
6Steroid biosynthesis_Homo sapiens_hsa001002.73058082
7RNA polymerase_Homo sapiens_hsa030202.52608141
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.43968709
9Spliceosome_Homo sapiens_hsa030402.26813865
10Fatty acid elongation_Homo sapiens_hsa000621.98837140
11Mismatch repair_Homo sapiens_hsa034301.85902702
12RNA transport_Homo sapiens_hsa030131.83914959
13Hedgehog signaling pathway_Homo sapiens_hsa043401.75212834
14Hippo signaling pathway_Homo sapiens_hsa043901.68127995
15Base excision repair_Homo sapiens_hsa034101.67994981
16DNA replication_Homo sapiens_hsa030301.66477435
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66118416
18Oxidative phosphorylation_Homo sapiens_hsa001901.60408746
19mRNA surveillance pathway_Homo sapiens_hsa030151.60164650
20Parkinsons disease_Homo sapiens_hsa050121.54936189
21Nucleotide excision repair_Homo sapiens_hsa034201.52536454
22Basal cell carcinoma_Homo sapiens_hsa052171.52394422
23Tight junction_Homo sapiens_hsa045301.50643932
24Arginine and proline metabolism_Homo sapiens_hsa003301.48399043
25Ether lipid metabolism_Homo sapiens_hsa005651.46688004
26Axon guidance_Homo sapiens_hsa043601.46591550
27Bladder cancer_Homo sapiens_hsa052191.36607959
28Renal cell carcinoma_Homo sapiens_hsa052111.35932396
29Carbon metabolism_Homo sapiens_hsa012001.35925926
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.35266709
31Notch signaling pathway_Homo sapiens_hsa043301.35194572
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32751357
33Galactose metabolism_Homo sapiens_hsa000521.32432910
34Fatty acid biosynthesis_Homo sapiens_hsa000611.28473578
35Homologous recombination_Homo sapiens_hsa034401.27129854
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.22422626
37Endocytosis_Homo sapiens_hsa041441.20335654
38One carbon pool by folate_Homo sapiens_hsa006701.16041718
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15741949
40Vibrio cholerae infection_Homo sapiens_hsa051101.13615271
41Proteasome_Homo sapiens_hsa030501.12355589
42Folate biosynthesis_Homo sapiens_hsa007901.11754389
43Epstein-Barr virus infection_Homo sapiens_hsa051691.10521542
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10510785
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09580963
46Regulation of actin cytoskeleton_Homo sapiens_hsa048101.08914152
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.08405216
48Primary immunodeficiency_Homo sapiens_hsa053401.07728764
49Cardiac muscle contraction_Homo sapiens_hsa042601.07504988
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06797273
51Sphingolipid signaling pathway_Homo sapiens_hsa040711.04242486
52Glutathione metabolism_Homo sapiens_hsa004801.03482896
53Prion diseases_Homo sapiens_hsa050200.99982259
54VEGF signaling pathway_Homo sapiens_hsa043700.99016739
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97887088
56Basal transcription factors_Homo sapiens_hsa030220.96160300
57ErbB signaling pathway_Homo sapiens_hsa040120.95168010
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.91056299
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89239432
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88401959
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87314052
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87185873
63Wnt signaling pathway_Homo sapiens_hsa043100.86606084
64mTOR signaling pathway_Homo sapiens_hsa041500.84528252
65Biosynthesis of amino acids_Homo sapiens_hsa012300.81723966
66Huntingtons disease_Homo sapiens_hsa050160.81540449
67Alzheimers disease_Homo sapiens_hsa050100.81076651
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80786986
69Oocyte meiosis_Homo sapiens_hsa041140.79875680
70Ras signaling pathway_Homo sapiens_hsa040140.79132845
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79051712
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77620394
73Linoleic acid metabolism_Homo sapiens_hsa005910.76387909
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75849286
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75773910
76Salmonella infection_Homo sapiens_hsa051320.75621750
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75147982
78Dorso-ventral axis formation_Homo sapiens_hsa043200.74358131
79Viral myocarditis_Homo sapiens_hsa054160.74027618
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73657103
81Fanconi anemia pathway_Homo sapiens_hsa034600.73410172
82Antigen processing and presentation_Homo sapiens_hsa046120.73248037
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72486617
84Sulfur metabolism_Homo sapiens_hsa009200.72134746
85N-Glycan biosynthesis_Homo sapiens_hsa005100.70781277
86MicroRNAs in cancer_Homo sapiens_hsa052060.69621502
87Leishmaniasis_Homo sapiens_hsa051400.69390166
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69243208
89Cell cycle_Homo sapiens_hsa041100.68975023
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.68580679
91HTLV-I infection_Homo sapiens_hsa051660.68124948
92Thyroid cancer_Homo sapiens_hsa052160.67321622
93Gap junction_Homo sapiens_hsa045400.67019367
94Osteoclast differentiation_Homo sapiens_hsa043800.67013841
95Sphingolipid metabolism_Homo sapiens_hsa006000.65984230
96Pentose phosphate pathway_Homo sapiens_hsa000300.65973172
97p53 signaling pathway_Homo sapiens_hsa041150.65593870
98Viral carcinogenesis_Homo sapiens_hsa052030.65016652
99Chronic myeloid leukemia_Homo sapiens_hsa052200.64950678
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64360072
101Fructose and mannose metabolism_Homo sapiens_hsa000510.63665702
102Alcoholism_Homo sapiens_hsa050340.62600373
103Apoptosis_Homo sapiens_hsa042100.62545675
104Long-term depression_Homo sapiens_hsa047300.62027181
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62001303
106Non-small cell lung cancer_Homo sapiens_hsa052230.61928961
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61881273
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61402217
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60044644
110Proteoglycans in cancer_Homo sapiens_hsa052050.58883539
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58739375
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58432979
113Arginine biosynthesis_Homo sapiens_hsa002200.58170139
114Pancreatic cancer_Homo sapiens_hsa052120.58105513
115Purine metabolism_Homo sapiens_hsa002300.57626630
116Focal adhesion_Homo sapiens_hsa045100.55345606
117Lysosome_Homo sapiens_hsa041420.55305977
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54379183
119Arachidonic acid metabolism_Homo sapiens_hsa005900.53837621
120Hepatitis C_Homo sapiens_hsa051600.53031658
121Collecting duct acid secretion_Homo sapiens_hsa049660.52975965
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.52963276
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.52198191
124Influenza A_Homo sapiens_hsa051640.52100019
125Synaptic vesicle cycle_Homo sapiens_hsa047210.51735675
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.51642561
127Pathways in cancer_Homo sapiens_hsa052000.51532563
128Herpes simplex infection_Homo sapiens_hsa051680.50011749
129Choline metabolism in cancer_Homo sapiens_hsa052310.49950988
130Acute myeloid leukemia_Homo sapiens_hsa052210.49762635
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48665060
132Shigellosis_Homo sapiens_hsa051310.46178988
133Hepatitis B_Homo sapiens_hsa051610.45232654
134Small cell lung cancer_Homo sapiens_hsa052220.45133557
135Pyrimidine metabolism_Homo sapiens_hsa002400.45031664
136NF-kappa B signaling pathway_Homo sapiens_hsa040640.44911529
137Tuberculosis_Homo sapiens_hsa051520.44815846
138Glioma_Homo sapiens_hsa052140.44588407
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44459923
140MAPK signaling pathway_Homo sapiens_hsa040100.44276627
141Metabolic pathways_Homo sapiens_hsa011000.43943295
142B cell receptor signaling pathway_Homo sapiens_hsa046620.43803709
143Allograft rejection_Homo sapiens_hsa053300.43466258
144ECM-receptor interaction_Homo sapiens_hsa045120.43126015
145Melanogenesis_Homo sapiens_hsa049160.42576734
146Measles_Homo sapiens_hsa051620.42034374
147Malaria_Homo sapiens_hsa051440.41217268
148Melanoma_Homo sapiens_hsa052180.39693355
149Central carbon metabolism in cancer_Homo sapiens_hsa052300.39597413
150Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39471261
151Pyruvate metabolism_Homo sapiens_hsa006200.39451374
152Pertussis_Homo sapiens_hsa051330.39164217
153Phagosome_Homo sapiens_hsa041450.38634675
154Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37071721
155Rap1 signaling pathway_Homo sapiens_hsa040150.36091122
156Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35547409
157Systemic lupus erythematosus_Homo sapiens_hsa053220.34782113

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