URGCP-MRPS24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring URGCP (upregulator of cell proliferation) and MRPS24 (mitochondrial ribosomal protein S24) genes on chromosome 7. The read-through transcript is predicted to encode a protein that shares sequence identity with the upstream gene product but its C-terminal region is distinct due to a frameshift relative to the downstream gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosome assembly (GO:0042255)5.69980921
2proteasome assembly (GO:0043248)5.64936888
3cullin deneddylation (GO:0010388)4.35936778
4negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.19186163
5regulation of cellular amino acid metabolic process (GO:0006521)4.18737052
6DNA deamination (GO:0045006)4.15782860
7protein maturation by protein folding (GO:0022417)4.11840514
8protein deneddylation (GO:0000338)4.11402159
9transcription from mitochondrial promoter (GO:0006390)4.01557968
10DNA damage response, detection of DNA damage (GO:0042769)3.95690818
11positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.92534392
12AMP metabolic process (GO:0046033)3.91312712
13DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.87975294
14negative regulation of ligase activity (GO:0051352)3.86704780
15negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.86704780
16signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.82870684
17signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.82870684
18signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.82870684
19maturation of 5.8S rRNA (GO:0000460)3.82344556
20regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.82189509
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.79036163
22signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.78248419
23intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.78248419
24establishment of protein localization to mitochondrial membrane (GO:0090151)3.73784432
25ATP synthesis coupled proton transport (GO:0015986)3.73777160
26energy coupled proton transport, down electrochemical gradient (GO:0015985)3.73777160
27exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.73441955
28respiratory chain complex IV assembly (GO:0008535)3.71077969
29rRNA modification (GO:0000154)3.71037433
30signal transduction involved in DNA damage checkpoint (GO:0072422)3.70703422
31signal transduction involved in DNA integrity checkpoint (GO:0072401)3.70703422
32signal transduction involved in cell cycle checkpoint (GO:0072395)3.69760844
33tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.68434981
34RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.68434981
35protein targeting to mitochondrion (GO:0006626)3.67433995
36nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.67130252
37chaperone-mediated protein transport (GO:0072321)3.66955902
38IMP biosynthetic process (GO:0006188)3.65573420
39anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.63722852
40mitochondrial RNA metabolic process (GO:0000959)3.60476625
41regulation of mitotic spindle checkpoint (GO:1903504)3.53890979
42regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.53890979
43purine nucleotide salvage (GO:0032261)3.46595612
44folic acid-containing compound biosynthetic process (GO:0009396)3.41257326
45positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.35733864
46establishment of protein localization to mitochondrion (GO:0072655)3.35568651
47GMP metabolic process (GO:0046037)3.34520543
48transcription elongation from RNA polymerase III promoter (GO:0006385)3.34458772
49termination of RNA polymerase III transcription (GO:0006386)3.34458772
50guanosine-containing compound biosynthetic process (GO:1901070)3.32233974
51water-soluble vitamin biosynthetic process (GO:0042364)3.31344032
52regulation of mitochondrial translation (GO:0070129)3.29523157
53positive regulation of ligase activity (GO:0051351)3.28046129
54establishment of integrated proviral latency (GO:0075713)3.27314049
55rRNA methylation (GO:0031167)3.25858216
56L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.25405521
57protein localization to mitochondrion (GO:0070585)3.25175124
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.23699658
59deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.20955701
60GTP biosynthetic process (GO:0006183)3.09801689
61establishment of viral latency (GO:0019043)3.06316141
62regulation of cellular amine metabolic process (GO:0033238)3.05233409
63positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.04368663
64pteridine-containing compound biosynthetic process (GO:0042559)3.04277911
65preassembly of GPI anchor in ER membrane (GO:0016254)3.03773226
66cytochrome complex assembly (GO:0017004)3.03402905
67somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.03147575
68somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.03147575
69isotype switching (GO:0045190)3.03147575
70protein complex biogenesis (GO:0070271)3.01987497
71DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.01257292
72antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.99323611
73tRNA processing (GO:0008033)2.98171535
74mitochondrial respiratory chain complex I assembly (GO:0032981)2.95938990
75NADH dehydrogenase complex assembly (GO:0010257)2.95938990
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.95938990
77branched-chain amino acid catabolic process (GO:0009083)2.94019017
78protein-cofactor linkage (GO:0018065)2.93399567
79regulation of ubiquitin-protein transferase activity (GO:0051438)2.92743924
80mitochondrial respiratory chain complex assembly (GO:0033108)2.92249254
81tRNA methylation (GO:0030488)2.92212652
82negative regulation of protein ubiquitination (GO:0031397)2.92096153
83nucleoside transmembrane transport (GO:1901642)2.91772031
84IMP metabolic process (GO:0046040)2.88748366
85pseudouridine synthesis (GO:0001522)2.88567835
86regulation of ligase activity (GO:0051340)2.88214633
87positive regulation of cell cycle arrest (GO:0071158)2.87863773
88mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.86473589
89positive regulation of actin filament depolymerization (GO:0030836)2.84311883
90nucleoside salvage (GO:0043174)2.84043603
91viral mRNA export from host cell nucleus (GO:0046784)2.83276141
92lipopolysaccharide biosynthetic process (GO:0009103)2.82108073
93lipopolysaccharide metabolic process (GO:0008653)2.82089768
94ribosomal large subunit biogenesis (GO:0042273)2.82071934
95DNA catabolic process, exonucleolytic (GO:0000738)2.81768937
96negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.81585599
97UTP metabolic process (GO:0046051)2.80816782
98protein peptidyl-prolyl isomerization (GO:0000413)2.79636789
99tRNA modification (GO:0006400)2.79170280
100tRNA metabolic process (GO:0006399)2.77088363

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.71204234
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.63710437
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.29461873
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.03209591
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.79100638
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.20377644
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.19918616
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.95013419
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.93249956
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.93246429
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.88395901
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.88036101
13VDR_23849224_ChIP-Seq_CD4+_Human2.86154019
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.79689888
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.66485030
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.63437983
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.63376164
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.60180069
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.53738350
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.51603492
21ELK1_19687146_ChIP-ChIP_HELA_Human2.45212091
22DCP1A_22483619_ChIP-Seq_HELA_Human2.43278733
23FOXP3_21729870_ChIP-Seq_TREG_Human2.42343105
24E2F7_22180533_ChIP-Seq_HELA_Human2.39651028
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.36970055
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.30881774
27GABP_19822575_ChIP-Seq_HepG2_Human2.29643791
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.27524083
29MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23253192
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.19275546
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.02789605
32E2F4_17652178_ChIP-ChIP_JURKAT_Human2.01816270
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.00801790
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.97585305
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90809969
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.89841207
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81865529
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78916936
39XRN2_22483619_ChIP-Seq_HELA_Human1.78670113
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.77129851
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75150256
42TTF2_22483619_ChIP-Seq_HELA_Human1.71532669
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67147057
44HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.65800098
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.63735646
46ELK1_22589737_ChIP-Seq_MCF10A_Human1.62379219
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58143042
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57110012
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44723288
50CIITA_25753668_ChIP-Seq_RAJI_Human1.44401401
51ZNF263_19887448_ChIP-Seq_K562_Human1.43460155
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36842657
53ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.36293534
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.32842960
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32527709
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28602674
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25000008
58ZNF274_21170338_ChIP-Seq_K562_Hela1.23500644
59KDM5A_27292631_Chip-Seq_BREAST_Human1.18012056
60TFEB_21752829_ChIP-Seq_HELA_Human1.17627169
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17136407
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.15434022
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15217841
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14093213
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13763807
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13502916
67MYC_18940864_ChIP-ChIP_HL60_Human1.13470269
68PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13344582
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11835445
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10009996
71CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06934093
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06440901
73POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04259766
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04090587
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02430693
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99778272
77ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99304076
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97778283
79FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96503850
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96454404
81TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88258251
82ELF5_23300383_ChIP-Seq_T47D_Human0.87422585
83SPI1_23547873_ChIP-Seq_NB4_Human0.82510977
84AR_20517297_ChIP-Seq_VCAP_Human0.82403273
85FLI1_27457419_Chip-Seq_LIVER_Mouse0.82113874
86TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.80384829
87STAT1_20625510_ChIP-Seq_HELA_Human0.80136755
88VDR_22108803_ChIP-Seq_LS180_Human0.79961808
89NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79824536
90TP53_22573176_ChIP-Seq_HFKS_Human0.79621497
91PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79281924
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78338784
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78193951
94STAT4_19710469_ChIP-ChIP_TH1__Mouse0.77299149
95E2F1_21310950_ChIP-Seq_MCF-7_Human0.74861711
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.74678128
97FOXP1_21924763_ChIP-Seq_HESCs_Human0.74626929
98ERG_20517297_ChIP-Seq_VCAP_Human0.72186683
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.71890091
100HIF1A_21447827_ChIP-Seq_MCF-7_Human0.71679561

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level5.03985858
2MP0003786_premature_aging3.89204094
3MP0003806_abnormal_nucleotide_metabolis3.29538188
4MP0008058_abnormal_DNA_repair3.02033957
5MP0003950_abnormal_plasma_membrane2.95400438
6MP0001542_abnormal_bone_strength2.86888897
7MP0005084_abnormal_gallbladder_morpholo2.49790973
8MP0005360_urolithiasis2.38353686
9MP0006035_abnormal_mitochondrial_morpho2.34981316
10MP0010094_abnormal_chromosome_stability2.31706643
11MP0006036_abnormal_mitochondrial_physio2.29074285
12MP0008875_abnormal_xenobiotic_pharmacok2.25174681
13MP0004957_abnormal_blastocyst_morpholog2.23372296
14MP0003718_maternal_effect2.19511025
15MP0008877_abnormal_DNA_methylation2.03877767
16MP0003186_abnormal_redox_activity2.01702595
17MP0009333_abnormal_splenocyte_physiolog1.92602338
18MP0001661_extended_life_span1.85913554
19MP0009697_abnormal_copulation1.84773701
20MP0005332_abnormal_amino_acid1.84437701
21MP0003724_increased_susceptibility_to1.82962357
22MP0005646_abnormal_pituitary_gland1.80881878
23MP0005671_abnormal_response_to1.74610704
24MP0001853_heart_inflammation1.74020250
25MP0003111_abnormal_nucleus_morphology1.70753853
26MP0002876_abnormal_thyroid_physiology1.69807508
27MP0008995_early_reproductive_senescence1.66769858
28MP0002148_abnormal_hypersensitivity_rea1.60887014
29MP0008057_abnormal_DNA_replication1.58212209
30MP0002396_abnormal_hematopoietic_system1.56648279
31MP0003077_abnormal_cell_cycle1.53902497
32MP0008007_abnormal_cellular_replicative1.52064714
33MP0000358_abnormal_cell_content/1.51261442
34MP0008775_abnormal_heart_ventricle1.47630454
35MP0003693_abnormal_embryo_hatching1.47580776
36MP0002837_dystrophic_cardiac_calcinosis1.47094548
37MP0001835_abnormal_antigen_presentation1.38386641
38MP0006072_abnormal_retinal_apoptosis1.35706378
39MP0000685_abnormal_immune_system1.33360051
40MP0005165_increased_susceptibility_to1.32937176
41MP0005000_abnormal_immune_tolerance1.29843468
42MP0001764_abnormal_homeostasis1.28938296
43MP0008872_abnormal_physiological_respon1.26593296
44MP0009785_altered_susceptibility_to1.26156620
45MP0002736_abnormal_nociception_after1.25077943
46MP0000858_altered_metastatic_potential1.22584967
47MP0003763_abnormal_thymus_physiology1.22342937
48MP0001243_abnormal_dermal_layer1.22286024
49MP0003191_abnormal_cellular_cholesterol1.21950965
50MP0002332_abnormal_exercise_endurance1.21682332
51MP0002877_abnormal_melanocyte_morpholog1.12292701
52MP0003252_abnormal_bile_duct1.12031912
53MP0002102_abnormal_ear_morphology1.11162898
54MP0002019_abnormal_tumor_incidence1.10818774
55MP0003866_abnormal_defecation1.07800201
56MP0005083_abnormal_biliary_tract1.07050412
57MP0003195_calcinosis1.06999530
58MP0001533_abnormal_skeleton_physiology1.03169139
59MP0003436_decreased_susceptibility_to1.03109765
60MP0009764_decreased_sensitivity_to1.01337774
61MP0002006_tumorigenesis1.01006028
62MP0005645_abnormal_hypothalamus_physiol1.00618685
63MP0002452_abnormal_antigen_presenting0.98936830
64MP0000749_muscle_degeneration0.96856856
65MP0009643_abnormal_urine_homeostasis0.94918846
66MP0005670_abnormal_white_adipose0.94038244
67MP0000647_abnormal_sebaceous_gland0.93786303
68MP0000013_abnormal_adipose_tissue0.92651242
69MP0008873_increased_physiological_sensi0.92444828
70MP0002723_abnormal_immune_serum0.91510409
71MP0001756_abnormal_urination0.90119453
72MP0002693_abnormal_pancreas_physiology0.88927911
73MP0003638_abnormal_response/metabolism_0.88243495
74MP0001727_abnormal_embryo_implantation0.87640065
75MP0001800_abnormal_humoral_immune0.87632242
76MP0000516_abnormal_urinary_system0.87204384
77MP0005367_renal/urinary_system_phenotyp0.87204384
78MP0001845_abnormal_inflammatory_respons0.86795493
79MP0005410_abnormal_fertilization0.85600504
80MP0001905_abnormal_dopamine_level0.85014414
81MP0001819_abnormal_immune_cell0.82960558
82MP0005636_abnormal_mineral_homeostasis0.82878787
83MP0003075_altered_response_to0.81486241
84MP0000689_abnormal_spleen_morphology0.79790237
85MP0001929_abnormal_gametogenesis0.78922396
86MP0002420_abnormal_adaptive_immunity0.78478319
87MP0005266_abnormal_metabolism0.77660224
88MP0008932_abnormal_embryonic_tissue0.77051277
89MP0003656_abnormal_erythrocyte_physiolo0.74687328
90MP0001216_abnormal_epidermal_layer0.74200464
91MP0004510_myositis0.72893301
92MP0000230_abnormal_systemic_arterial0.72879092
93MP0001919_abnormal_reproductive_system0.70797285
94MP0002722_abnormal_immune_system0.69666981
95MP0003315_abnormal_perineum_morphology0.69447898
96MP0002398_abnormal_bone_marrow0.68885017
97MP0002210_abnormal_sex_determination0.67957582
98MP0008469_abnormal_protein_level0.67677878
99MP0002429_abnormal_blood_cell0.66983675
100MP0000653_abnormal_sex_gland0.64430878

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.10603000
2Abnormal mitochondria in muscle tissue (HP:0008316)3.88457454
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.71277180
4Abnormality of alanine metabolism (HP:0010916)3.71277180
5Hyperalaninemia (HP:0003348)3.71277180
6Mitochondrial inheritance (HP:0001427)3.61335301
7Type I transferrin isoform profile (HP:0003642)3.58120063
8Acute encephalopathy (HP:0006846)3.52967104
9Increased CSF lactate (HP:0002490)3.46330759
10Methylmalonic aciduria (HP:0012120)3.41844084
11Methylmalonic acidemia (HP:0002912)3.40019311
12Adrenal hypoplasia (HP:0000835)3.37606448
13Progressive macrocephaly (HP:0004481)3.33190150
14Hepatocellular necrosis (HP:0001404)3.32898155
15Hepatic necrosis (HP:0002605)3.26201576
16Abnormal protein glycosylation (HP:0012346)3.13873287
17Abnormal glycosylation (HP:0012345)3.13873287
18Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.13873287
19Abnormal protein N-linked glycosylation (HP:0012347)3.13873287
20Congenital, generalized hypertrichosis (HP:0004540)3.08227753
21Delayed CNS myelination (HP:0002188)3.05272758
22Cerebral edema (HP:0002181)3.02564386
23Increased serum pyruvate (HP:0003542)2.94580150
24Increased serum lactate (HP:0002151)2.93609935
25Abnormality of methionine metabolism (HP:0010901)2.90161562
26Short tibia (HP:0005736)2.88273527
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.85476963
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.85476963
29Lactic acidosis (HP:0003128)2.85441033
30IgG deficiency (HP:0004315)2.82342466
31Abnormality of glycolysis (HP:0004366)2.81959255
32Increased hepatocellular lipid droplets (HP:0006565)2.79457695
33Reduced subcutaneous adipose tissue (HP:0003758)2.79198627
34Constricted visual fields (HP:0001133)2.74764722
35Ureteral duplication (HP:0000073)2.74370114
36Duplicated collecting system (HP:0000081)2.72319455
37Opisthotonus (HP:0002179)2.71087168
38Abnormality of homocysteine metabolism (HP:0010919)2.69139419
39Homocystinuria (HP:0002156)2.69139419
40Prostate neoplasm (HP:0100787)2.64590663
41Lipid accumulation in hepatocytes (HP:0006561)2.60336817
42Abnormality of aspartate family amino acid metabolism (HP:0010899)2.56783906
43Rough bone trabeculation (HP:0100670)2.53141643
44Testicular atrophy (HP:0000029)2.51981083
45Renal cortical cysts (HP:0000803)2.45643908
46Ketoacidosis (HP:0001993)2.44780165
47Aplasia/Hypoplasia of the tibia (HP:0005772)2.41120842
48Abnormality of serum amino acid levels (HP:0003112)2.40989956
49Exercise intolerance (HP:0003546)2.39572734
50Abnormality of the renal collecting system (HP:0004742)2.38205583
51Tongue fasciculations (HP:0001308)2.37437734
52Abnormality of dicarboxylic acid metabolism (HP:0010995)2.36642435
53Dicarboxylic aciduria (HP:0003215)2.36642435
54Entropion (HP:0000621)2.33465828
55Brittle hair (HP:0002299)2.33197433
56Abnormality of sulfur amino acid metabolism (HP:0004339)2.32707525
57Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.32240853
58Lethargy (HP:0001254)2.29576468
59Generalized aminoaciduria (HP:0002909)2.27730507
60Abnormality of the vitamin B12 metabolism (HP:0004341)2.19177414
61Respiratory failure (HP:0002878)2.17741924
62Sparse eyelashes (HP:0000653)2.15010363
63Prominent metopic ridge (HP:0005487)2.14806968
64Abnormality of vitamin B metabolism (HP:0004340)2.14490883
65Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.12334426
66Pancytopenia (HP:0001876)2.11394099
67Optic disc pallor (HP:0000543)2.09192430
68Renal Fanconi syndrome (HP:0001994)2.09064637
69Poor speech (HP:0002465)2.08555089
70Progressive microcephaly (HP:0000253)2.05409897
71Large for gestational age (HP:0001520)2.02785530
72Cerebral hypomyelination (HP:0006808)2.01906145
73Stomach cancer (HP:0012126)2.01071678
74Glucose intolerance (HP:0000833)1.98802248
75Metabolic acidosis (HP:0001942)1.95655981
76Reduced antithrombin III activity (HP:0001976)1.93337835
77Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.92653230
78Absent thumb (HP:0009777)1.91705716
79Abnormality of the umbilical cord (HP:0010881)1.91094893
80Abnormal spermatogenesis (HP:0008669)1.90436344
81Aplasia/hypoplasia of the uterus (HP:0008684)1.88952575
82Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87440856
83Increased intramyocellular lipid droplets (HP:0012240)1.84968908
84Muscle fibrillation (HP:0010546)1.83382746
85Oral leukoplakia (HP:0002745)1.83035954
86Nausea (HP:0002018)1.82575508
87Hyperglycemia (HP:0003074)1.80369110
88Abnormal trabecular bone morphology (HP:0100671)1.79921991
89CNS hypomyelination (HP:0003429)1.78613737
90Decreased subcutaneous fat (HP:0001002)1.78453452
91Neutropenia (HP:0001875)1.78202047
92Hypoglycemic coma (HP:0001325)1.76383088
93Insulin resistance (HP:0000855)1.76332842
94Median cleft lip (HP:0000161)1.75422793
95Delayed gross motor development (HP:0002194)1.74165917
96Horseshoe kidney (HP:0000085)1.73626108
97Hypokinesia (HP:0002375)1.72664454
98Abnormality of T cell physiology (HP:0011840)1.71132705
99Abnormality of the distal phalanges of the toes (HP:0010182)1.69734618
100Ketosis (HP:0001946)1.69146416

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.99832961
2TAOK33.54269258
3VRK23.52461591
4MST43.14315348
5TXK2.89693943
6NEK12.50892093
7LIMK12.49481247
8NME22.38814908
9TSSK62.29811585
10MAP4K22.27935137
11TESK22.24983011
12EIF2AK12.16374702
13TESK12.05794450
14MAP3K122.05387308
15DAPK11.98821505
16GRK71.89774109
17GRK51.89007443
18SRPK11.88998289
19STK101.86803145
20ZAK1.83139873
21BCKDK1.74565327
22EIF2AK31.66690875
23NUAK11.61941294
24CSNK1G31.59537748
25EIF2AK21.44474184
26EPHA21.44162235
27MOS1.39482986
28TGFBR21.39112161
29CSNK1A1L1.35907882
30PBK1.34540410
31PHKG21.33674858
32PHKG11.33674858
33TLK11.32187029
34ACVR1B1.30890223
35MAP2K21.24991592
36GRK61.24243288
37CSNK1G11.22337515
38PLK31.21747529
39OXSR11.18654841
40MAPKAPK31.13864024
41STK161.10218001
42CSNK1G21.09635804
43MYLK1.09599385
44FER1.09450616
45TRIM281.09012469
46ILK1.07791616
47BMPR21.04375097
48PAK41.02844866
49PIM20.98659373
50VRK10.97135264
51ERBB30.97087306
52IRAK30.90095965
53KDR0.86684310
54GRK10.86678759
55PRKCI0.82549402
56CDC70.80327452
57TTK0.79611911
58PLK40.71143078
59PLK10.71105136
60RPS6KB20.70777613
61IKBKB0.68662557
62RIPK40.66660065
63RPS6KA50.64798735
64RPS6KA40.62010040
65AURKA0.59111784
66ADRBK10.58339032
67WNK40.57557712
68PAK10.56048942
69NEK20.54174648
70TAOK20.53286954
71ABL20.52761923
72TBK10.52069597
73MAP2K70.51328796
74AURKB0.50439758
75MST1R0.49639358
76FES0.49046262
77MAPKAPK20.47839462
78ADRBK20.44929326
79MKNK10.44834925
80NME10.44579272
81JAK30.43071755
82LMTK20.42533973
83ATR0.42527688
84MAPKAPK50.38746727
85CDK70.38706061
86ARAF0.37277940
87STK390.37077626
88ERBB40.36107699
89CCNB10.35967401
90CHEK20.35833996
91ITK0.35343332
92PRKCE0.34689438
93PLK20.34023891
94CDK190.32955337
95BRSK10.32939461
96TAF10.32538020
97PINK10.31267399
98INSRR0.30682740
99IGF1R0.30603575
100CDK80.29336670

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.29015394
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.11886015
3Oxidative phosphorylation_Homo sapiens_hsa001902.97958724
4RNA polymerase_Homo sapiens_hsa030202.86472192
5DNA replication_Homo sapiens_hsa030302.60524362
6Parkinsons disease_Homo sapiens_hsa050122.46360206
7RNA degradation_Homo sapiens_hsa030182.27138104
8One carbon pool by folate_Homo sapiens_hsa006702.26824788
9Mismatch repair_Homo sapiens_hsa034302.13102601
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.00948588
11Pyrimidine metabolism_Homo sapiens_hsa002401.99776446
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.87131960
13Protein export_Homo sapiens_hsa030601.86826979
14Ribosome_Homo sapiens_hsa030101.83934807
15Nucleotide excision repair_Homo sapiens_hsa034201.82794983
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81097964
17Spliceosome_Homo sapiens_hsa030401.75375074
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.74989530
19Homologous recombination_Homo sapiens_hsa034401.74910266
20RNA transport_Homo sapiens_hsa030131.72373308
21Base excision repair_Homo sapiens_hsa034101.68804360
22Huntingtons disease_Homo sapiens_hsa050161.67332348
23Basal transcription factors_Homo sapiens_hsa030221.66735617
24Fatty acid elongation_Homo sapiens_hsa000621.65512949
25Alzheimers disease_Homo sapiens_hsa050101.64079189
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63085115
27Selenocompound metabolism_Homo sapiens_hsa004501.51629489
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49196632
29Sulfur metabolism_Homo sapiens_hsa009201.47477963
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47023470
31Folate biosynthesis_Homo sapiens_hsa007901.46841158
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.44172639
33Purine metabolism_Homo sapiens_hsa002301.43930827
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42492242
35Non-homologous end-joining_Homo sapiens_hsa034501.37913700
36Sulfur relay system_Homo sapiens_hsa041221.34773670
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33202958
38Pyruvate metabolism_Homo sapiens_hsa006201.25906335
39Glutathione metabolism_Homo sapiens_hsa004801.24236591
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20969218
41Peroxisome_Homo sapiens_hsa041461.16206841
42Collecting duct acid secretion_Homo sapiens_hsa049661.13700694
43Biosynthesis of amino acids_Homo sapiens_hsa012301.11589071
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09991531
45Propanoate metabolism_Homo sapiens_hsa006401.07191117
46Galactose metabolism_Homo sapiens_hsa000520.98594622
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97799032
48Fanconi anemia pathway_Homo sapiens_hsa034600.97770108
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96551777
50Vibrio cholerae infection_Homo sapiens_hsa051100.95010418
51Tryptophan metabolism_Homo sapiens_hsa003800.91569114
52Carbon metabolism_Homo sapiens_hsa012000.90927980
53Metabolic pathways_Homo sapiens_hsa011000.83768500
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81901704
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80243769
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75640239
57N-Glycan biosynthesis_Homo sapiens_hsa005100.75510182
58Pentose phosphate pathway_Homo sapiens_hsa000300.69483049
59Legionellosis_Homo sapiens_hsa051340.66913915
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66299173
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.63195062
62Arachidonic acid metabolism_Homo sapiens_hsa005900.60603054
63Salivary secretion_Homo sapiens_hsa049700.60120716
64Primary immunodeficiency_Homo sapiens_hsa053400.59298264
65Chemical carcinogenesis_Homo sapiens_hsa052040.56595049
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.53736071
67Shigellosis_Homo sapiens_hsa051310.52591410
68Nitrogen metabolism_Homo sapiens_hsa009100.51556206
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51427469
70Butanoate metabolism_Homo sapiens_hsa006500.49748604
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.49667581
72Steroid biosynthesis_Homo sapiens_hsa001000.49378479
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49353577
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.48585762
75Regulation of autophagy_Homo sapiens_hsa041400.48499813
76p53 signaling pathway_Homo sapiens_hsa041150.48003144
77Ether lipid metabolism_Homo sapiens_hsa005650.47812622
78Linoleic acid metabolism_Homo sapiens_hsa005910.47129285
79Cell cycle_Homo sapiens_hsa041100.46113919
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46006021
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44779920
82Epstein-Barr virus infection_Homo sapiens_hsa051690.43861796
83Vitamin B6 metabolism_Homo sapiens_hsa007500.43498705
84Cardiac muscle contraction_Homo sapiens_hsa042600.42456610
85Rheumatoid arthritis_Homo sapiens_hsa053230.42272775
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.41875417
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39648254
88Fructose and mannose metabolism_Homo sapiens_hsa000510.39357530
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38515580
90Fatty acid metabolism_Homo sapiens_hsa012120.36931250
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.33348102
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31656929
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29517144
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29087378
95Arginine and proline metabolism_Homo sapiens_hsa003300.29082744
96Synaptic vesicle cycle_Homo sapiens_hsa047210.28946739
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28733729
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28360196
99Antigen processing and presentation_Homo sapiens_hsa046120.27579553
100Caffeine metabolism_Homo sapiens_hsa002320.26219218

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »