URAHP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline metabolic process (GO:0006560)4.12307485
2protein carboxylation (GO:0018214)3.85788827
3peptidyl-glutamic acid carboxylation (GO:0017187)3.85788827
4GDP-mannose metabolic process (GO:0019673)3.65307443
5pattern specification involved in kidney development (GO:0061004)3.45790497
6homocysteine metabolic process (GO:0050667)3.36718756
7sulfur amino acid catabolic process (GO:0000098)3.35877906
8G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.25626640
9L-phenylalanine catabolic process (GO:0006559)3.25562696
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.25562696
11cysteine metabolic process (GO:0006534)3.22133991
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.09655018
13L-phenylalanine metabolic process (GO:0006558)3.09655018
14lung epithelium development (GO:0060428)3.09402293
15planar cell polarity pathway involved in neural tube closure (GO:0090179)3.05966812
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.99156077
17regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.89755256
18regulation of mitochondrial translation (GO:0070129)2.88894700
19serine family amino acid catabolic process (GO:0009071)2.85148980
20purine nucleotide transport (GO:0015865)2.83258028
21positive regulation of smoothened signaling pathway (GO:0045880)2.82319370
22energy coupled proton transport, down electrochemical gradient (GO:0015985)2.80115303
23ATP synthesis coupled proton transport (GO:0015986)2.80115303
24cell proliferation involved in metanephros development (GO:0072203)2.79602592
25establishment of protein localization to mitochondrial membrane (GO:0090151)2.76898291
26positive regulation of fatty acid beta-oxidation (GO:0032000)2.76143576
27proline biosynthetic process (GO:0006561)2.75328880
28cellular modified amino acid catabolic process (GO:0042219)2.74006798
29alanine transport (GO:0032328)2.73349471
30exogenous drug catabolic process (GO:0042738)2.72816009
31exocrine pancreas development (GO:0031017)2.72359695
32cellular ketone body metabolic process (GO:0046950)2.71894489
33histone H4-K12 acetylation (GO:0043983)2.67956513
34intestinal cholesterol absorption (GO:0030299)2.66923737
35purine ribonucleotide transport (GO:0015868)2.64483362
36RNA localization (GO:0006403)2.63435594
37adenine nucleotide transport (GO:0051503)2.63054867
38cochlea morphogenesis (GO:0090103)2.56603367
39epithelial cell fate commitment (GO:0072148)2.55350043
40protein-cofactor linkage (GO:0018065)2.54858701
41positive regulation of fatty acid oxidation (GO:0046321)2.54627999
42aromatic amino acid family catabolic process (GO:0009074)2.52678129
43otic vesicle formation (GO:0030916)2.52222383
44midbrain development (GO:0030901)2.50619957
45nephron epithelium morphogenesis (GO:0072088)2.47897038
46nephron tubule morphogenesis (GO:0072078)2.47897038
47purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.47220870
483-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.47220870
49hindbrain development (GO:0030902)2.47089125
50drug catabolic process (GO:0042737)2.46763159
51regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.45639059
52dopaminergic neuron differentiation (GO:0071542)2.45517152
53cell proliferation involved in kidney development (GO:0072111)2.44611301
54renal system development (GO:0072001)2.44409028
55positive regulation of gastrulation (GO:2000543)2.44266684
56axonemal dynein complex assembly (GO:0070286)2.43801410
57urinary tract smooth muscle contraction (GO:0014848)2.43752337
58ethanol metabolic process (GO:0006067)2.42759708
59negative regulation of cell aging (GO:0090344)2.42198483
60detection of light stimulus involved in visual perception (GO:0050908)2.41072021
61detection of light stimulus involved in sensory perception (GO:0050962)2.41072021
62response to misfolded protein (GO:0051788)2.40968695
63omega-hydroxylase P450 pathway (GO:0097267)2.38891202
64ketone body metabolic process (GO:1902224)2.38073919
65estrogen biosynthetic process (GO:0006703)2.37977103
664-hydroxyproline metabolic process (GO:0019471)2.36827092
67nucleoside transmembrane transport (GO:1901642)2.35492384
68L-serine transport (GO:0015825)2.34674596
69serine family amino acid biosynthetic process (GO:0009070)2.34588305
70regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.33092555
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.32327214
72mitochondrial respiratory chain complex I assembly (GO:0032981)2.32327214
73NADH dehydrogenase complex assembly (GO:0010257)2.32327214
74regulation of fibrinolysis (GO:0051917)2.31848868
75nucleoside transport (GO:0015858)2.31826148
76protein insertion into membrane (GO:0051205)2.31759344
77DNA replication checkpoint (GO:0000076)2.31368848
78regulation of fatty acid oxidation (GO:0046320)2.30511141
79alkaloid metabolic process (GO:0009820)2.30229719
80peptidyl-glutamic acid modification (GO:0018200)2.27166637
81Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.26404163
82ethanol oxidation (GO:0006069)2.25963157
83alpha-amino acid catabolic process (GO:1901606)2.24447254
84neurotransmitter catabolic process (GO:0042135)2.24180405
85positive regulation of protein kinase C signaling (GO:0090037)2.23648478
86cellular amino acid catabolic process (GO:0009063)2.22361734
87regulation of cholesterol biosynthetic process (GO:0045540)2.20995528
88left/right pattern formation (GO:0060972)2.20934715
89regulation of establishment of planar polarity (GO:0090175)2.19995506
90endocrine pancreas development (GO:0031018)2.19947505
91regulation of synapse structural plasticity (GO:0051823)2.19722760
92DNA strand renaturation (GO:0000733)2.19273453
93cranial nerve development (GO:0021545)2.18952045
94rRNA modification (GO:0000154)2.18479299
95negative regulation of T cell differentiation in thymus (GO:0033085)2.18328207
96lateral sprouting from an epithelium (GO:0060601)2.18306946
97L-alpha-amino acid transmembrane transport (GO:1902475)2.16875846
98branching involved in salivary gland morphogenesis (GO:0060445)2.15956235
99artery smooth muscle contraction (GO:0014824)2.15788599
100regulation of acyl-CoA biosynthetic process (GO:0050812)2.15186177

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.48678366
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.67740203
3ZNF263_19887448_ChIP-Seq_K562_Human2.42140135
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36733144
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36189065
6CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.35334222
7XRN2_22483619_ChIP-Seq_HELA_Human2.28690992
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.27507945
9ERG_21242973_ChIP-ChIP_JURKAT_Human2.20213793
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.18239128
11P68_20966046_ChIP-Seq_HELA_Human1.90172624
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89674710
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.86936457
14CTCF_27219007_Chip-Seq_Bcells_Human1.84862331
15RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.75222992
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74965371
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72221464
18LXR_22292898_ChIP-Seq_THP-1_Human1.70991319
19RACK7_27058665_Chip-Seq_MCF-7_Human1.68744739
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.68717850
21ESR1_21235772_ChIP-Seq_MCF-7_Human1.67782686
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.63617353
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61015184
24E2F1_20622854_ChIP-Seq_HELA_Human1.57526405
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52552539
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52474463
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49252830
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.48067645
29FOXP1_21924763_ChIP-Seq_HESCs_Human1.44731069
30CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.44471353
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.43930150
32SMC4_20622854_ChIP-Seq_HELA_Human1.41524421
33RARA_24833708_ChIP-Seq_LIVER_Mouse1.40327453
34RARB_24833708_ChIP-Seq_LIVER_Mouse1.38545482
35PPARA_22158963_ChIP-Seq_LIVER_Mouse1.36775641
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34653513
37SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33742070
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33620999
39ERA_21632823_ChIP-Seq_H3396_Human1.33255838
40RXR_22158963_ChIP-Seq_LIVER_Mouse1.32652537
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.32446450
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31356943
43PHF8_20622854_ChIP-Seq_HELA_Human1.29044602
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28219628
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.27852355
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.27798031
47BCOR_27268052_Chip-Seq_Bcells_Human1.26506964
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.24031958
49MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.23396749
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22406890
51RUNX1_27514584_Chip-Seq_MCF-7_Human1.20131526
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19664115
53SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18073491
54EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16786314
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16266243
56SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15835652
57CREB1_26743006_Chip-Seq_LNCaP_Human1.15079353
58SA1_27219007_Chip-Seq_ERYTHROID_Human1.13533143
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.12312662
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11102428
61YY1_22570637_ChIP-Seq_MALME-3M_Human1.10591296
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09847629
63TTF2_22483619_ChIP-Seq_HELA_Human1.09762425
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09696069
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08598783
66CTCF_20526341_ChIP-Seq_ESCs_Human1.08010741
67EED_16625203_ChIP-ChIP_MESCs_Mouse1.07734592
68SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05935780
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04403281
70CTCF_26484167_Chip-Seq_Bcells_Mouse1.03925789
71NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.03250169
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03117618
73EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01285141
74DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00795454
75BCL6_27268052_Chip-Seq_Bcells_Human1.00514794
76EZH2_27304074_Chip-Seq_ESCs_Mouse0.99686574
77SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98865921
78DCP1A_22483619_ChIP-Seq_HELA_Human0.98101242
79SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97974745
80VDR_21846776_ChIP-Seq_THP-1_Human0.96416924
81RXRA_24833708_ChIP-Seq_LIVER_Mouse0.95898807
82P53_21459846_ChIP-Seq_SAOS-2_Human0.95759427
83TP53_22127205_ChIP-Seq_IMR90_Human0.95173039
84NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93949859
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93779050
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93018671
87ETS1_20019798_ChIP-Seq_JURKAT_Human0.92690876
88SOX3_22085726_ChIP-Seq_NPCs_Mouse0.92646693
89KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.92187755
90BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92123338
91DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92077274
92RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91681887
93TP53_20018659_ChIP-ChIP_R1E_Mouse0.91500911
94STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.90919497
95KDM5A_27292631_Chip-Seq_BREAST_Human0.90805457
96SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90483331
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.90469830
98TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90220858
99CTCF_21964334_Chip-Seq_Bcells_Human0.89468778
100SA1_27219007_Chip-Seq_Bcells_Human0.89439546

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.47363273
2MP0003136_yellow_coat_color4.29474447
3MP0008875_abnormal_xenobiotic_pharmacok2.96973833
4MP0010030_abnormal_orbit_morphology2.69460904
5MP0005084_abnormal_gallbladder_morpholo2.48144545
6MP0002938_white_spotting2.47047023
7MP0002249_abnormal_larynx_morphology2.34128438
8MP0009780_abnormal_chondrocyte_physiolo2.32538431
9MP0009379_abnormal_foot_pigmentation2.26455289
10MP0001188_hyperpigmentation2.13389503
11MP0005083_abnormal_biliary_tract2.08821577
12MP0006292_abnormal_olfactory_placode1.96585128
13MP0002139_abnormal_hepatobiliary_system1.92321718
14MP0005365_abnormal_bile_salt1.89435155
15MP0002282_abnormal_trachea_morphology1.85926116
16MP0005332_abnormal_amino_acid1.82950897
17MP0005670_abnormal_white_adipose1.80175144
18MP0005377_hearing/vestibular/ear_phenot1.79996034
19MP0003878_abnormal_ear_physiology1.79996034
20MP0002909_abnormal_adrenal_gland1.75388993
21MP0005171_absent_coat_pigmentation1.66158070
22MP0005409_darkened_coat_color1.62192916
23MP0005423_abnormal_somatic_nervous1.62144340
24MP0004133_heterotaxia1.59352653
25MP0002653_abnormal_ependyma_morphology1.51487132
26MP0002928_abnormal_bile_duct1.50689677
27MP0001529_abnormal_vocalization1.48554031
28MP0001944_abnormal_pancreas_morphology1.35471968
29MP0005220_abnormal_exocrine_pancreas1.34164608
30MP0002089_abnormal_postnatal_growth/wei1.29270875
31MP0003122_maternal_imprinting1.28448782
32MP0002876_abnormal_thyroid_physiology1.25235501
33MP0001764_abnormal_homeostasis1.25174739
34MP0003283_abnormal_digestive_organ1.16689201
35MP0005174_abnormal_tail_pigmentation1.14784021
36MP0010329_abnormal_lipoprotein_level1.14224792
37MP0004019_abnormal_vitamin_homeostasis1.09139886
38MP0001756_abnormal_urination1.07785517
39MP0000026_abnormal_inner_ear1.07019038
40MP0001293_anophthalmia1.05481408
41MP0005408_hypopigmentation1.04254109
42MP0002160_abnormal_reproductive_system1.04092213
43MP0005085_abnormal_gallbladder_physiolo1.03844213
44MP0002277_abnormal_respiratory_mucosa1.03271840
45MP0010094_abnormal_chromosome_stability1.00404906
46MP0005187_abnormal_penis_morphology1.00176131
47MP0005360_urolithiasis0.99512131
48MP0005503_abnormal_tendon_morphology0.97571088
49MP0000538_abnormal_urinary_bladder0.95900307
50MP0003942_abnormal_urinary_system0.95611968
51MP0002697_abnormal_eye_size0.94460689
52MP0000631_abnormal_neuroendocrine_gland0.92466050
53MP0005551_abnormal_eye_electrophysiolog0.91779388
54MP0000462_abnormal_digestive_system0.91605504
55MP0003937_abnormal_limbs/digits/tail_de0.91363446
56MP0003938_abnormal_ear_development0.91305472
57MP0002254_reproductive_system_inflammat0.89808216
58MP0000751_myopathy0.88853660
59MP0002132_abnormal_respiratory_system0.88623934
60MP0003123_paternal_imprinting0.88081373
61MP0001986_abnormal_taste_sensitivity0.84607246
62MP0003718_maternal_effect0.84521398
63MP0008872_abnormal_physiological_respon0.84139111
64MP0001661_extended_life_span0.82185183
65MP0003638_abnormal_response/metabolism_0.81660030
66MP0001984_abnormal_olfaction0.81377341
67MP0005410_abnormal_fertilization0.80454588
68MP0002184_abnormal_innervation0.80277051
69MP0001485_abnormal_pinna_reflex0.80170358
70MP0001346_abnormal_lacrimal_gland0.78958581
71MP0001186_pigmentation_phenotype0.76982143
72MP0005394_taste/olfaction_phenotype0.75632808
73MP0005499_abnormal_olfactory_system0.75632808
74MP0008007_abnormal_cellular_replicative0.74432676
75MP0001905_abnormal_dopamine_level0.73776977
76MP0002932_abnormal_joint_morphology0.73289562
77MP0000013_abnormal_adipose_tissue0.73283522
78MP0004924_abnormal_behavior0.73186853
79MP0005386_behavior/neurological_phenoty0.73186853
80MP0000647_abnormal_sebaceous_gland0.72343494
81MP0001664_abnormal_digestion0.72332714
82MP0001299_abnormal_eye_distance/0.71750547
83MP0003195_calcinosis0.70872870
84MP0000678_abnormal_parathyroid_gland0.70298181
85MP0000534_abnormal_ureter_morphology0.70011674
86MP0002118_abnormal_lipid_homeostasis0.68390905
87MP0000778_abnormal_nervous_system0.68040383
88MP0002075_abnormal_coat/hair_pigmentati0.68002142
89MP0008789_abnormal_olfactory_epithelium0.67996538
90MP0000003_abnormal_adipose_tissue0.67777374
91MP0001849_ear_inflammation0.66586900
92MP0005645_abnormal_hypothalamus_physiol0.66424830
93MP0000049_abnormal_middle_ear0.66150247
94MP0000467_abnormal_esophagus_morphology0.65235702
95MP0005330_cardiomyopathy0.64315529
96MP0002638_abnormal_pupillary_reflex0.63521307
97MP0001929_abnormal_gametogenesis0.62985326
98MP0003698_abnormal_male_reproductive0.62904237
99MP0001502_abnormal_circadian_rhythm0.62710982
100MP0001324_abnormal_eye_pigmentation0.62655364

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)3.77196390
2Partial duplication of thumb phalanx (HP:0009944)3.49846861
3Rib fusion (HP:0000902)3.49305311
4Testicular atrophy (HP:0000029)3.35086863
5Bronchomalacia (HP:0002780)3.31147162
6Partial duplication of the phalanx of hand (HP:0009999)3.15613642
7Vaginal fistula (HP:0004320)3.05522485
8Hyperglycinuria (HP:0003108)3.02274344
9Broad metatarsal (HP:0001783)2.89860608
10Rectal fistula (HP:0100590)2.87904703
11Rectovaginal fistula (HP:0000143)2.87904703
12Coronal craniosynostosis (HP:0004440)2.77348951
13Turricephaly (HP:0000262)2.76388127
1411 pairs of ribs (HP:0000878)2.62655108
15Abnormality of aromatic amino acid family metabolism (HP:0004338)2.53789769
16Intestinal fistula (HP:0100819)2.46285244
17Bilateral microphthalmos (HP:0007633)2.42290219
18Hydroxyprolinuria (HP:0003080)2.38318128
19Abnormality of proline metabolism (HP:0010907)2.38318128
20Abnormality of serine family amino acid metabolism (HP:0010894)2.35126087
21Abnormality of glycine metabolism (HP:0010895)2.35126087
22Increased hepatocellular lipid droplets (HP:0006565)2.30240020
23Hypoplasia of the capital femoral epiphysis (HP:0003090)2.22328024
24Chronic hepatic failure (HP:0100626)2.20808247
25Maternal diabetes (HP:0009800)2.20185731
26Abnormality of the phalanges of the hallux (HP:0010057)2.20181646
27Deep venous thrombosis (HP:0002625)2.18054688
28Reduced antithrombin III activity (HP:0001976)2.16607004
29Duplication of thumb phalanx (HP:0009942)2.15691149
30Abnormality of sulfur amino acid metabolism (HP:0004339)2.13898357
31Abnormality of methionine metabolism (HP:0010901)2.13348992
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.12327563
33Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.12158668
34Abnormal sex determination (HP:0012244)2.11955795
35Sex reversal (HP:0012245)2.11955795
36Abnormality of midbrain morphology (HP:0002418)2.11791098
37Molar tooth sign on MRI (HP:0002419)2.11791098
38Mesangial abnormality (HP:0001966)2.09112244
39True hermaphroditism (HP:0010459)2.07556249
40Abnormality of the intrinsic pathway (HP:0010989)2.07133729
41Preaxial foot polydactyly (HP:0001841)2.06845175
42Joint hemorrhage (HP:0005261)2.06657389
43Birth length less than 3rd percentile (HP:0003561)2.06081138
44Ulnar bowing (HP:0003031)2.02394355
45Abnormal urine phosphate concentration (HP:0012599)2.02373706
46Dynein arm defect of respiratory motile cilia (HP:0012255)2.02369728
47Absent/shortened dynein arms (HP:0200106)2.02369728
48Neonatal short-limb short stature (HP:0008921)2.01176160
49Renal Fanconi syndrome (HP:0001994)2.00736745
50Lipid accumulation in hepatocytes (HP:0006561)2.00672137
51Facial hemangioma (HP:0000329)1.99676423
52Pheochromocytoma (HP:0002666)1.98668683
53Ketoacidosis (HP:0001993)1.97153127
54Down-sloping shoulders (HP:0200021)1.96066655
55Spontaneous abortion (HP:0005268)1.94983477
56Thin bony cortex (HP:0002753)1.94677300
57Aplasia involving bones of the upper limbs (HP:0009823)1.94155644
58Aplasia of the phalanges of the hand (HP:0009802)1.94155644
59Aplasia involving bones of the extremities (HP:0009825)1.94155644
60Abnormality of the distal phalanx of the thumb (HP:0009617)1.94008211
61Squamous cell carcinoma (HP:0002860)1.92803678
62Absent epiphyses (HP:0010577)1.92459923
63Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.92459923
64Respiratory distress (HP:0002098)1.89319174
65Attenuation of retinal blood vessels (HP:0007843)1.88671418
66Abnormality of the diencephalon (HP:0010662)1.84931504
67Bifid scrotum (HP:0000048)1.82718209
68Abnormal ciliary motility (HP:0012262)1.78415512
69Hypoplasia of the pons (HP:0012110)1.77824705
70Infertility (HP:0000789)1.77548432
71Akinesia (HP:0002304)1.76708306
72Tinnitus (HP:0000360)1.74456850
73Bifid tongue (HP:0010297)1.74195378
74Abnormality of glutamine family amino acid metabolism (HP:0010902)1.74006190
75Midline defect of the nose (HP:0004122)1.73577009
76Short chin (HP:0000331)1.73434014
77Choanal stenosis (HP:0000452)1.73364381
78Microretrognathia (HP:0000308)1.73298870
79Pendular nystagmus (HP:0012043)1.72648652
80Abnormal respiratory motile cilium physiology (HP:0012261)1.70721611
81Ketosis (HP:0001946)1.69715955
82Congenital, generalized hypertrichosis (HP:0004540)1.69491461
83Meningioma (HP:0002858)1.68723620
84Abnormal respiratory motile cilium morphology (HP:0005938)1.68714186
85Abnormal respiratory epithelium morphology (HP:0012253)1.68714186
86Neonatal onset (HP:0003623)1.68590584
87Abnormal number of incisors (HP:0011064)1.68166523
88Intrahepatic cholestasis (HP:0001406)1.67694687
89Patellar aplasia (HP:0006443)1.66742691
90Cystic liver disease (HP:0006706)1.62479826
91Infantile muscular hypotonia (HP:0008947)1.62270904
92Occipital encephalocele (HP:0002085)1.62185483
93Congenital stationary night blindness (HP:0007642)1.61441298
94Concave nail (HP:0001598)1.60114788
95Renal dysplasia (HP:0000110)1.58337105
96Broad face (HP:0000283)1.57599891
97Neuroendocrine neoplasm (HP:0100634)1.57503582
98Anophthalmia (HP:0000528)1.56647817
99Severe muscular hypotonia (HP:0006829)1.55877258
100Neoplasm of the heart (HP:0100544)1.55668760

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.55378730
2PNCK3.80195212
3EPHA22.87426010
4WNK42.70541986
5NME12.58326882
6BUB12.54350375
7PINK12.53315625
8TRIB32.48999115
9NTRK32.40175140
10TSSK62.36293895
11LATS22.36077072
12TLK12.28630451
13DYRK32.27491256
14FGFR22.26714656
15SIK12.15128859
16NEK21.88279719
17WEE11.82190272
18PHKG21.78575483
19PHKG11.78575483
20TRIM281.70641766
21MUSK1.52854278
22BCKDK1.44075303
23BRSK21.34577585
24PLK41.31755387
25NME21.23439913
26PKN21.18770783
27DYRK21.16986244
28ERBB41.16834613
29BRSK11.14020242
30MAP2K61.11584524
31SIK21.10780556
32DYRK1B1.07060844
33MAP3K91.04531197
34TTK1.04166808
35MET1.03637134
36STK390.98580800
37IRAK30.95552998
38MAP3K60.90100559
39EEF2K0.86968329
40MAP2K70.86152054
41ADRBK20.86050266
42ICK0.77243690
43PTK20.75987315
44PRKCI0.75064480
45ERBB20.74199186
46STK160.72561400
47GRK10.72114866
48ZAK0.71628492
49CDK120.71232033
50TYRO30.70956435
51CDK30.68035845
52FGFR10.66614631
53PLK10.65548203
54MAPKAPK50.65274437
55MST40.64941015
56TRPM70.64635536
57ADRBK10.64301723
58BMX0.63407234
59ARAF0.62265590
60UHMK10.61020474
61CDK70.60750733
62MARK10.59763966
63CCNB10.59456722
64MAPK130.58727988
65CDK80.58326298
66PTK60.58293174
67MST1R0.56174436
68RPS6KA20.53912283
69PBK0.53560615
70RPS6KA60.50269468
71MAPKAPK30.49851445
72DMPK0.47260169
73CAMK1G0.46894506
74MTOR0.46786394
75WNK10.46167724
76FGFR40.45885137
77AURKA0.44658867
78INSRR0.44654906
79CHEK20.43995982
80AURKB0.42579468
81GRK60.42393653
82MAP3K70.42009156
83PRKCG0.41878906
84IRAK20.41536504
85EPHA40.40840464
86WNK30.40437340
87DAPK20.39881735
88KSR20.39853640
89BRAF0.38533842
90VRK20.37418493
91MARK20.36970761
92PDPK10.36462469
93CSNK1E0.35351944
94CAMK2D0.33305767
95MAP3K20.33055877
96ILK0.32875389
97VRK10.32765290
98PLK30.32741780
99MINK10.32627728
100RPS6KA50.31354137

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041222.94942905
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.83689094
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.63320338
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.47388539
5Selenocompound metabolism_Homo sapiens_hsa004502.13733287
6Tyrosine metabolism_Homo sapiens_hsa003502.03990481
7Ribosome_Homo sapiens_hsa030101.89415328
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.89251249
9Phenylalanine metabolism_Homo sapiens_hsa003601.88178417
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.67339675
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.67045796
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.66131459
13Pyruvate metabolism_Homo sapiens_hsa006201.65214666
14Cyanoamino acid metabolism_Homo sapiens_hsa004601.64103278
15Caffeine metabolism_Homo sapiens_hsa002321.62572374
16Chemical carcinogenesis_Homo sapiens_hsa052041.57991942
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.56154105
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54969875
19Oxidative phosphorylation_Homo sapiens_hsa001901.51024144
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.45530867
21Basal cell carcinoma_Homo sapiens_hsa052171.45328833
22Butanoate metabolism_Homo sapiens_hsa006501.43428592
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41405073
24Steroid biosynthesis_Homo sapiens_hsa001001.38646214
25Histidine metabolism_Homo sapiens_hsa003401.38399163
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.36485858
27Hedgehog signaling pathway_Homo sapiens_hsa043401.35766440
28Retinol metabolism_Homo sapiens_hsa008301.31141501
29Linoleic acid metabolism_Homo sapiens_hsa005911.31131035
30Arginine biosynthesis_Homo sapiens_hsa002201.31083786
31Cocaine addiction_Homo sapiens_hsa050301.29734617
32ABC transporters_Homo sapiens_hsa020101.29417394
33Vitamin B6 metabolism_Homo sapiens_hsa007501.27463195
34Fatty acid degradation_Homo sapiens_hsa000711.22804339
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22356483
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21319041
37Tryptophan metabolism_Homo sapiens_hsa003801.19984546
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19536750
39Arginine and proline metabolism_Homo sapiens_hsa003301.15147904
40Parkinsons disease_Homo sapiens_hsa050121.11103008
41Huntingtons disease_Homo sapiens_hsa050161.08793180
42Glutathione metabolism_Homo sapiens_hsa004801.06810824
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06711108
44Vitamin digestion and absorption_Homo sapiens_hsa049771.03280064
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02991370
46One carbon pool by folate_Homo sapiens_hsa006701.02920363
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01911143
48Bile secretion_Homo sapiens_hsa049760.98345405
49Mismatch repair_Homo sapiens_hsa034300.96953745
50Homologous recombination_Homo sapiens_hsa034400.96296919
51beta-Alanine metabolism_Homo sapiens_hsa004100.96112460
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94504653
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94101907
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93740626
55Fructose and mannose metabolism_Homo sapiens_hsa000510.92647835
56Complement and coagulation cascades_Homo sapiens_hsa046100.89358850
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87190300
58Cardiac muscle contraction_Homo sapiens_hsa042600.86434892
59Biosynthesis of amino acids_Homo sapiens_hsa012300.82505066
60Fatty acid metabolism_Homo sapiens_hsa012120.80790880
61Alzheimers disease_Homo sapiens_hsa050100.80314341
62Fanconi anemia pathway_Homo sapiens_hsa034600.80106133
63Fat digestion and absorption_Homo sapiens_hsa049750.79492167
64Metabolic pathways_Homo sapiens_hsa011000.75431664
65Taste transduction_Homo sapiens_hsa047420.73630073
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73187695
67Lysine degradation_Homo sapiens_hsa003100.72583124
68Pyrimidine metabolism_Homo sapiens_hsa002400.68972494
69PPAR signaling pathway_Homo sapiens_hsa033200.67816243
70Peroxisome_Homo sapiens_hsa041460.67811208
71Ovarian steroidogenesis_Homo sapiens_hsa049130.66057004
72Nucleotide excision repair_Homo sapiens_hsa034200.65288603
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63189610
74RNA polymerase_Homo sapiens_hsa030200.60499726
75Melanogenesis_Homo sapiens_hsa049160.60266049
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59201257
77N-Glycan biosynthesis_Homo sapiens_hsa005100.57876981
78Propanoate metabolism_Homo sapiens_hsa006400.57769479
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57435726
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56035715
81Hippo signaling pathway_Homo sapiens_hsa043900.54739770
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.53431710
83Serotonergic synapse_Homo sapiens_hsa047260.53143728
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51193313
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51079152
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50801561
87Starch and sucrose metabolism_Homo sapiens_hsa005000.50370017
88Glutamatergic synapse_Homo sapiens_hsa047240.49879249
89Insulin secretion_Homo sapiens_hsa049110.48873151
90Amphetamine addiction_Homo sapiens_hsa050310.47413106
91Purine metabolism_Homo sapiens_hsa002300.45281707
92Arachidonic acid metabolism_Homo sapiens_hsa005900.44054786
93Fatty acid biosynthesis_Homo sapiens_hsa000610.43944702
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.43509831
95Sphingolipid metabolism_Homo sapiens_hsa006000.40988382
96Circadian entrainment_Homo sapiens_hsa047130.40698215
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40017361
98Notch signaling pathway_Homo sapiens_hsa043300.39174138
99Carbon metabolism_Homo sapiens_hsa012000.38475229
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38298446

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