UQCRQ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.87204121
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.30604176
3energy coupled proton transport, down electrochemical gradient (GO:0015985)8.21019173
4ATP synthesis coupled proton transport (GO:0015986)8.21019173
5* respiratory electron transport chain (GO:0022904)7.74282514
6* electron transport chain (GO:0022900)7.53622293
7oxidative phosphorylation (GO:0006119)5.26872457
8ATP biosynthetic process (GO:0006754)4.89109779
9maturation of SSU-rRNA (GO:0030490)4.77617748
10protein complex biogenesis (GO:0070271)4.65822117
11tricarboxylic acid cycle (GO:0006099)4.60933550
12purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.47739358
13purine nucleoside triphosphate biosynthetic process (GO:0009145)4.47345614
14cellular ketone body metabolic process (GO:0046950)4.44240191
15mitochondrial respiratory chain complex I assembly (GO:0032981)4.43132352
16NADH dehydrogenase complex assembly (GO:0010257)4.43132352
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.43132352
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.41606952
19translational initiation (GO:0006413)4.38053719
20mitochondrial respiratory chain complex assembly (GO:0033108)4.37893824
21* hydrogen ion transmembrane transport (GO:1902600)4.19806571
22transcription elongation from RNA polymerase III promoter (GO:0006385)4.16163165
23termination of RNA polymerase III transcription (GO:0006386)4.16163165
24inner mitochondrial membrane organization (GO:0007007)4.11895264
25L-phenylalanine metabolic process (GO:0006558)4.07068869
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.07068869
27regulation of mitochondrial translation (GO:0070129)4.06176696
28ribonucleoside triphosphate biosynthetic process (GO:0009201)3.92585669
29deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.87536002
30protein complex disassembly (GO:0043241)3.87147922
31ketone body metabolic process (GO:1902224)3.86146787
32NADH metabolic process (GO:0006734)3.82813011
33aerobic respiration (GO:0009060)3.81762852
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.77378452
35protein targeting to membrane (GO:0006612)3.74851661
36erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.74004519
37L-phenylalanine catabolic process (GO:0006559)3.74004519
38macromolecular complex disassembly (GO:0032984)3.72712972
39chaperone-mediated protein transport (GO:0072321)3.72482117
40cellular component biogenesis (GO:0044085)3.71533446
41ubiquinone biosynthetic process (GO:0006744)3.68977789
42quinone biosynthetic process (GO:1901663)3.68977789
43aldehyde catabolic process (GO:0046185)3.68434388
44pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.67591689
45viral transcription (GO:0019083)3.66361053
46establishment of protein localization to mitochondrial membrane (GO:0090151)3.64329927
47sarcomere organization (GO:0045214)3.62528634
48* proton transport (GO:0015992)3.60524990
49* hydrogen transport (GO:0006818)3.55399550
50regulation of cellular amino acid metabolic process (GO:0006521)3.52523377
51translational termination (GO:0006415)3.50317923
52positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.48148768
53negative regulation of ligase activity (GO:0051352)3.47942887
54negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.47942887
55succinate metabolic process (GO:0006105)3.43557532
56respiratory chain complex IV assembly (GO:0008535)3.43246815
57nucleoside triphosphate biosynthetic process (GO:0009142)3.42196219
58ribosomal small subunit biogenesis (GO:0042274)3.40682894
59short-chain fatty acid metabolic process (GO:0046459)3.39542165
60glyoxylate metabolic process (GO:0046487)3.39196361
61intracellular protein transmembrane import (GO:0044743)3.37728233
62rRNA modification (GO:0000154)3.35762868
63regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.35323834
64protein-cofactor linkage (GO:0018065)3.35179110
65cullin deneddylation (GO:0010388)3.34985006
66mitochondrial transport (GO:0006839)3.32483704
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.31537159
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.31537159
69aspartate family amino acid catabolic process (GO:0009068)3.29064093
70lysine catabolic process (GO:0006554)3.28808411
71lysine metabolic process (GO:0006553)3.28808411
72branched-chain amino acid catabolic process (GO:0009083)3.28562208
73ribonucleoprotein complex biogenesis (GO:0022613)3.27845009
74sequestering of actin monomers (GO:0042989)3.26708215
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.26049094
76cytochrome complex assembly (GO:0017004)3.25347143
77fatty acid beta-oxidation (GO:0006635)3.25254638
78cotranslational protein targeting to membrane (GO:0006613)3.23722509
79DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.23372356
80ubiquinone metabolic process (GO:0006743)3.23284464
81nuclear-transcribed mRNA catabolic process (GO:0000956)3.23013382
82SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.22990391
83anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.22796888
84water-soluble vitamin biosynthetic process (GO:0042364)3.21514446
85protein targeting to ER (GO:0045047)3.21458834
86exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16954017
87regulation of oxidative phosphorylation (GO:0002082)3.15167791
88protein deneddylation (GO:0000338)3.14355589
89signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.13904877
90signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.13904877
91signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.13904877
92purine nucleoside monophosphate biosynthetic process (GO:0009127)3.13015025
93purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.13015025
94intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.12935119
95signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.12935119
96pseudouridine synthesis (GO:0001522)3.12469852
97cellular respiration (GO:0045333)3.12230931
98actin-myosin filament sliding (GO:0033275)3.11553822
99muscle filament sliding (GO:0030049)3.11553822
100fatty acid catabolic process (GO:0009062)3.10812207
101oxaloacetate metabolic process (GO:0006107)3.10731619
102protein localization to endoplasmic reticulum (GO:0070972)3.09234533
103establishment of protein localization to endoplasmic reticulum (GO:0072599)3.07054750
104aromatic amino acid family catabolic process (GO:0009074)3.06357647
105mRNA catabolic process (GO:0006402)3.04818015
106protein neddylation (GO:0045116)3.04701631
107positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.04355540
108signal transduction involved in DNA damage checkpoint (GO:0072422)3.04013464
109signal transduction involved in DNA integrity checkpoint (GO:0072401)3.04013464
110translational elongation (GO:0006414)3.03872576
111* generation of precursor metabolites and energy (GO:0006091)3.03506616
112UTP biosynthetic process (GO:0006228)3.02956628
113GTP biosynthetic process (GO:0006183)3.02942884
114rRNA processing (GO:0006364)3.02148699
115protein targeting to mitochondrion (GO:0006626)3.01454975
116spliceosomal snRNP assembly (GO:0000387)3.00385303
117signal transduction involved in cell cycle checkpoint (GO:0072395)2.99337624
118heart process (GO:0003015)2.95239328
119heart contraction (GO:0060047)2.95239328
120pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.92886880
121ribosomal small subunit assembly (GO:0000028)2.91854439
122fatty acid oxidation (GO:0019395)2.91852442
123establishment of protein localization to mitochondrion (GO:0072655)2.91419355
124rRNA metabolic process (GO:0016072)2.90491578
125monocarboxylic acid catabolic process (GO:0072329)2.90122879
126pyrimidine nucleotide catabolic process (GO:0006244)2.90097587
127positive regulation of ligase activity (GO:0051351)2.89770555
128lipid oxidation (GO:0034440)2.85693958
129proteasome assembly (GO:0043248)2.82017889
130ribosomal large subunit biogenesis (GO:0042273)2.81071892
131protein localization to mitochondrion (GO:0070585)2.80962913
132purine nucleoside biosynthetic process (GO:0042451)2.80060640
133purine ribonucleoside biosynthetic process (GO:0046129)2.80060640
134cysteine metabolic process (GO:0006534)2.78949264
135regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.78428585
136cardiac myofibril assembly (GO:0055003)2.77992705
137coenzyme catabolic process (GO:0009109)2.77575080
138kynurenine metabolic process (GO:0070189)2.77528941
1392-oxoglutarate metabolic process (GO:0006103)2.77096014
140triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.75181070
141heme biosynthetic process (GO:0006783)2.74964178
142branched-chain amino acid metabolic process (GO:0009081)2.74144005
143acetyl-CoA metabolic process (GO:0006084)2.74035427
144translation (GO:0006412)2.73886055
145cellular protein complex disassembly (GO:0043624)2.73098730
146viral life cycle (GO:0019058)2.72645093
147regulation of cellular respiration (GO:0043457)2.70411490
148regulation of triglyceride catabolic process (GO:0010896)2.69930772
149myofibril assembly (GO:0030239)2.66908953
150cofactor catabolic process (GO:0051187)2.66615713

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.58954896
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.32069256
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.10339533
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.75637308
5* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.60837674
6* RXR_22158963_ChIP-Seq_LIVER_Mouse3.29440103
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.14647621
8* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.14009851
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.11280800
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.10930123
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.04783636
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.00874067
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.92505357
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.90745310
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.86095569
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.85880842
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.78852194
18EGR1_23403033_ChIP-Seq_LIVER_Mouse2.62719233
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.51991165
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.51282562
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.50864819
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.49809666
23ELK1_19687146_ChIP-ChIP_HELA_Human2.37658196
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.32943667
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.29669113
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29100161
27* LXR_22158963_ChIP-Seq_LIVER_Mouse2.24937523
28* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.17364782
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.15817157
30* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.12591227
31* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.10098537
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.04352173
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02989161
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97309087
35* DCP1A_22483619_ChIP-Seq_HELA_Human1.79827649
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.75871256
37SRY_22984422_ChIP-ChIP_TESTIS_Rat1.74739994
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71390872
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67075842
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66384105
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57130183
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52454532
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52447122
44BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.48036793
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41107755
46* XRN2_22483619_ChIP-Seq_HELA_Human1.40808205
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38986449
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37284314
49CTCF_18555785_ChIP-Seq_MESCs_Mouse1.36902292
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36684884
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.35836160
52* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33366693
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33187587
54PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.30501380
55ELK1_22589737_ChIP-Seq_MCF10A_Human1.28869802
56SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.23856263
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23455352
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22938082
59ZNF263_19887448_ChIP-Seq_K562_Human1.22903944
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22643292
61* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22204365
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20947514
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20569074
64* VDR_23849224_ChIP-Seq_CD4+_Human1.16810912
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16311640
66FOXP3_21729870_ChIP-Seq_TREG_Human1.13021961
67TTF2_22483619_ChIP-Seq_HELA_Human1.12092543
68RAD21_21589869_ChIP-Seq_MESCs_Mouse1.10692336
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09489968
70CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.09335252
71* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08682628
72NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07714305
73GABP_19822575_ChIP-Seq_HepG2_Human1.04343561
74YY1_22570637_ChIP-Seq_MALME-3M_Human1.03417312
75* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01322706
76KDM5A_27292631_Chip-Seq_BREAST_Human0.99548103
77NANOG_20526341_ChIP-Seq_ESCs_Human0.99149910
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97823687
79EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97414122
80SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97251469
81OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96630288
82SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95635047
83TP53_22573176_ChIP-Seq_HFKS_Human0.95616048
84PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94227962
85HTT_18923047_ChIP-ChIP_STHdh_Human0.93945012
86SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93854162
87SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93643924
88STAT1_20625510_ChIP-Seq_HELA_Human0.93338810
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93330834
90* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92862997
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92643205
92TET1_21451524_ChIP-Seq_MESCs_Mouse0.92124127
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91635501
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90490797
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90252074
96MYCN_18555785_ChIP-Seq_MESCs_Mouse0.88078626
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87905969
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87557050
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86901089
100NANOG_18555785_ChIP-Seq_MESCs_Mouse0.86700251
101MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.86340214
102ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84320917
103SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83390105
104BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82472386
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82159771
106ZNF274_21170338_ChIP-Seq_K562_Hela0.80749546
107* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.80310426
108FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80210884
109CTCF_26484167_Chip-Seq_Bcells_Mouse0.80068298
110* MYC_18940864_ChIP-ChIP_HL60_Human0.79576107
111CTCF_20526341_ChIP-Seq_ESCs_Human0.79527601
112SOX2_18555785_ChIP-Seq_MESCs_Mouse0.79308035
113PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79305829
114CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.79222589
115E2F1_21310950_ChIP-Seq_MCF-7_Human0.78942821
116SOX17_20123909_ChIP-Seq_XEN_Mouse0.78559871
117TAF2_19829295_ChIP-Seq_ESCs_Human0.77943280
118SOX2_16153702_ChIP-ChIP_HESCs_Human0.77463751
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76119143
120ELF1_17652178_ChIP-ChIP_JURKAT_Human0.75275904
121AR_20517297_ChIP-Seq_VCAP_Human0.75026119
122CSB_26484114_Chip-Seq_FIBROBLAST_Human0.74669505
123E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.74484754
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.74484547
125* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.73926681
126FOXP1_21924763_ChIP-Seq_HESCs_Human0.73418142
127BMI1_23680149_ChIP-Seq_NPCS_Mouse0.73317661
128MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.73316089
129EZH2_22144423_ChIP-Seq_EOC_Human0.72689545
130RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.72062371
131BCL6_27268052_Chip-Seq_Bcells_Human0.70963191
132EWS_26573619_Chip-Seq_HEK293_Human0.70666518
133VDR_22108803_ChIP-Seq_LS180_Human0.70164631
134GATA4_21415370_ChIP-Seq_HL-1_Mouse0.70049826
135ERG_20517297_ChIP-Seq_VCAP_Human0.68918314
136ERA_21632823_ChIP-Seq_H3396_Human0.68604472
137MYC_19829295_ChIP-Seq_ESCs_Human0.68208030
138AUTS2_25519132_ChIP-Seq_293T-REX_Human0.68165489
139ETV2_25802403_ChIP-Seq_MESCs_Mouse0.67746438
140NANOG_16153702_ChIP-ChIP_HESCs_Human0.67670838
141NELFA_20434984_ChIP-Seq_ESCs_Mouse0.67243805
142E2F7_22180533_ChIP-Seq_HELA_Human0.66840664

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.89808674
2MP0002139_abnormal_hepatobiliary_system4.48972644
3MP0003646_muscle_fatigue4.18078273
4MP0005360_urolithiasis3.99004548
5MP0003806_abnormal_nucleotide_metabolis3.79343927
6MP0005085_abnormal_gallbladder_physiolo3.53362307
7MP0009379_abnormal_foot_pigmentation3.29201559
8MP0006036_abnormal_mitochondrial_physio3.22366563
9MP0008875_abnormal_xenobiotic_pharmacok2.95010118
10MP0000751_myopathy2.91481211
11MP0004084_abnormal_cardiac_muscle2.90460789
12MP0004215_abnormal_myocardial_fiber2.83449852
13MP0000749_muscle_degeneration2.75560647
14MP0005365_abnormal_bile_salt2.62681729
15MP0005330_cardiomyopathy2.58696408
16MP0004036_abnormal_muscle_relaxation2.55240338
17MP0000372_irregular_coat_pigmentation2.38308966
18MP0003195_calcinosis2.25536263
19MP0005083_abnormal_biliary_tract2.17655984
20MP0006035_abnormal_mitochondrial_morpho2.16882418
21MP0005332_abnormal_amino_acid2.13008858
22MP0002938_white_spotting2.11815900
23MP0006292_abnormal_olfactory_placode2.09347560
24MP0008058_abnormal_DNA_repair2.07543218
25MP0003186_abnormal_redox_activity2.00859233
26MP0003137_abnormal_impulse_conducting1.99008528
27MP0006072_abnormal_retinal_apoptosis1.95938070
28MP0002972_abnormal_cardiac_muscle1.84076792
29MP0001529_abnormal_vocalization1.76429688
30MP0003786_premature_aging1.72782723
31MP0010030_abnormal_orbit_morphology1.66948131
32MP0003011_delayed_dark_adaptation1.66675114
33MP0004043_abnormal_pH_regulation1.66671337
34MP0000750_abnormal_muscle_regeneration1.66353138
35MP0005451_abnormal_body_composition1.65435136
36MP0002822_catalepsy1.64446978
37MP0003693_abnormal_embryo_hatching1.64271942
38MP0008789_abnormal_olfactory_epithelium1.59321462
39MP0005620_abnormal_muscle_contractility1.57318521
40MP0004087_abnormal_muscle_fiber1.55334723
41MP0009840_abnormal_foam_cell1.54352884
42MP0004957_abnormal_blastocyst_morpholog1.51309720
43MP0002234_abnormal_pharynx_morphology1.50468436
44MP0001666_abnormal_nutrient_absorption1.50213665
45MP0001544_abnormal_cardiovascular_syste1.49790469
46MP0005385_cardiovascular_system_phenoty1.49790469
47MP0002638_abnormal_pupillary_reflex1.49652028
48MP0008775_abnormal_heart_ventricle1.47579483
49MP0002277_abnormal_respiratory_mucosa1.46700590
50MP0005584_abnormal_enzyme/coenzyme_acti1.43485138
51MP0004130_abnormal_muscle_cell1.41209884
52MP0002160_abnormal_reproductive_system1.41028049
53MP0002332_abnormal_exercise_endurance1.40780422
54MP0010329_abnormal_lipoprotein_level1.40173476
55MP0001764_abnormal_homeostasis1.40012395
56MP0006276_abnormal_autonomic_nervous1.38727623
57MP0005319_abnormal_enzyme/_coenzyme1.36927100
58MP0002163_abnormal_gland_morphology1.34825504
59MP0005266_abnormal_metabolism1.33241714
60MP0004484_altered_response_of1.33068311
61MP0003136_yellow_coat_color1.32322192
62MP0001984_abnormal_olfaction1.30919184
63MP0003252_abnormal_bile_duct1.29090545
64MP0001485_abnormal_pinna_reflex1.28990116
65MP0002269_muscular_atrophy1.28739166
66MP0009697_abnormal_copulation1.28592315
67MP0005551_abnormal_eye_electrophysiolog1.27446748
68MP0005636_abnormal_mineral_homeostasis1.26998347
69MP0006138_congestive_heart_failure1.26120724
70MP0009046_muscle_twitch1.26018010
71MP0004145_abnormal_muscle_electrophysio1.24794788
72MP0002106_abnormal_muscle_physiology1.24228129
73MP0003221_abnormal_cardiomyocyte_apopto1.24074413
74MP0003123_paternal_imprinting1.22004499
75MP0000747_muscle_weakness1.20252967
76MP0004019_abnormal_vitamin_homeostasis1.19105224
77MP0005670_abnormal_white_adipose1.19030123
78MP0008995_early_reproductive_senescence1.17086922
79MP0002118_abnormal_lipid_homeostasis1.16671940
80MP0008932_abnormal_embryonic_tissue1.16641931
81MP0005084_abnormal_gallbladder_morpholo1.16263579
82MP0004085_abnormal_heartbeat1.15982474
83MP0005646_abnormal_pituitary_gland1.15143850
84MP0009643_abnormal_urine_homeostasis1.14059489
85MP0004142_abnormal_muscle_tone1.09894534
86MP0000230_abnormal_systemic_arterial1.09217016
87MP0005389_reproductive_system_phenotype1.09041213
88MP0002272_abnormal_nervous_system1.07491788
89MP0005379_endocrine/exocrine_gland_phen1.05537197
90MP0002653_abnormal_ependyma_morphology1.05169704
91MP0000631_abnormal_neuroendocrine_gland1.05168535
92MP0002102_abnormal_ear_morphology1.05007423
93MP0001968_abnormal_touch/_nociception1.04379239
94MP0000759_abnormal_skeletal_muscle1.03925371
95MP0002095_abnormal_skin_pigmentation1.02774150
96MP0005165_increased_susceptibility_to1.00856149
97MP0005253_abnormal_eye_physiology1.00806185
98MP0009745_abnormal_behavioral_response0.99670002
99MP0005666_abnormal_adipose_tissue0.99566483
100MP0005369_muscle_phenotype0.98896203
101MP0010630_abnormal_cardiac_muscle0.97780780
102MP0003315_abnormal_perineum_morphology0.97397020
103MP0003828_pulmonary_edema0.97312582
104MP0010386_abnormal_urinary_bladder0.97248953
105MP0000049_abnormal_middle_ear0.97084006
106MP0005376_homeostasis/metabolism_phenot0.94653676
107MP0010094_abnormal_chromosome_stability0.94148614
108MP0003656_abnormal_erythrocyte_physiolo0.93413056
109MP0001919_abnormal_reproductive_system0.92512738
110MP0005645_abnormal_hypothalamus_physiol0.90722363
111MP0005535_abnormal_body_temperature0.90275159
112MP0002127_abnormal_cardiovascular_syste0.89900028
113MP0003077_abnormal_cell_cycle0.89596103
114MP0003868_abnormal_feces_composition0.85457418
115MP0005394_taste/olfaction_phenotype0.84307312
116MP0005499_abnormal_olfactory_system0.84307312
117MP0002138_abnormal_hepatobiliary_system0.83934367
118MP0002736_abnormal_nociception_after0.83753613
119MP0008007_abnormal_cellular_replicative0.83298945
120MP0004133_heterotaxia0.83283920
121MP0000609_abnormal_liver_physiology0.82730736
122MP0002210_abnormal_sex_determination0.82311956
123MP0000358_abnormal_cell_content/0.80902879
124MP0001293_anophthalmia0.79990496
125MP0001905_abnormal_dopamine_level0.79652776
126MP0003950_abnormal_plasma_membrane0.78032996
127MP0004147_increased_porphyrin_level0.77519522
128MP0000026_abnormal_inner_ear0.77056574
129MP0005410_abnormal_fertilization0.74318058
130MP0000566_synostosis0.73935277
131MP0008004_abnormal_stomach_pH0.73481299
132MP0008872_abnormal_physiological_respon0.73329922
133MP0002876_abnormal_thyroid_physiology0.73258317
134MP0003718_maternal_effect0.73202870
135MP0001756_abnormal_urination0.72203201
136MP0001188_hyperpigmentation0.69804406
137MP0002064_seizures0.69047849
138MP0003724_increased_susceptibility_to0.68643742
139MP0002078_abnormal_glucose_homeostasis0.67983621
140MP0003191_abnormal_cellular_cholesterol0.67546597
141MP0001727_abnormal_embryo_implantation0.67397035
142MP0001970_abnormal_pain_threshold0.67321338
143MP0003638_abnormal_response/metabolism_0.67068057
144MP0002971_abnormal_brown_adipose0.65218192
145MP0005195_abnormal_posterior_eye0.65218147
146MP0000343_altered_response_to0.64674047
147MP0002734_abnormal_mechanical_nocicepti0.64416418
148MP0003938_abnormal_ear_development0.64388290
149MP0001663_abnormal_digestive_system0.63173418
150MP0003880_abnormal_central_pattern0.59473718
151MP0005381_digestive/alimentary_phenotyp0.56157868
152MP0009642_abnormal_blood_homeostasis0.56106203
153MP0002132_abnormal_respiratory_system0.55446885
154MP0001542_abnormal_bone_strength0.51641423
155MP0005408_hypopigmentation0.51556196
156MP0005595_abnormal_vascular_smooth0.49711690
157MP0001765_abnormal_ion_homeostasis0.49121527
158MP0001664_abnormal_digestion0.48791093
159MP0001440_abnormal_grooming_behavior0.48470337

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.44851069
2Abnormal mitochondria in muscle tissue (HP:0008316)6.09838762
3Mitochondrial inheritance (HP:0001427)5.90375685
4Acute encephalopathy (HP:0006846)5.88377295
5Hepatocellular necrosis (HP:0001404)5.62722214
6Hepatic necrosis (HP:0002605)5.59259871
7Progressive macrocephaly (HP:0004481)5.37252879
8Increased CSF lactate (HP:0002490)5.20489009
9Cerebral edema (HP:0002181)4.94508516
10Lipid accumulation in hepatocytes (HP:0006561)4.33773096
11Increased intramyocellular lipid droplets (HP:0012240)4.30980403
12Increased hepatocellular lipid droplets (HP:0006565)4.29187476
13Increased muscle lipid content (HP:0009058)4.22620916
14Abnormal number of erythroid precursors (HP:0012131)4.21921584
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.15105577
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.02003948
17Decreased activity of mitochondrial respiratory chain (HP:0008972)4.02003948
18Lactic acidosis (HP:0003128)3.98158283
19Respiratory failure (HP:0002878)3.91386202
20Sudden death (HP:0001699)3.72706477
21Exercise intolerance (HP:0003546)3.72374666
22Renal Fanconi syndrome (HP:0001994)3.65584516
23Increased serum pyruvate (HP:0003542)3.48453151
24Abnormality of glycolysis (HP:0004366)3.48453151
25Reticulocytopenia (HP:0001896)3.41231963
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.39918430
27Lethargy (HP:0001254)3.39821843
28* Increased serum lactate (HP:0002151)3.37588859
29Dicarboxylic aciduria (HP:0003215)3.32396386
30Abnormality of dicarboxylic acid metabolism (HP:0010995)3.32396386
31Palpitations (HP:0001962)3.22331558
32Optic disc pallor (HP:0000543)3.20007703
33Calf muscle hypertrophy (HP:0008981)3.09849754
34Abnormality of aromatic amino acid family metabolism (HP:0004338)3.05273375
35Ventricular tachycardia (HP:0004756)3.03233506
36Muscle hypertrophy of the lower extremities (HP:0008968)3.01394584
373-Methylglutaconic aciduria (HP:0003535)3.00671957
38Leukodystrophy (HP:0002415)3.00515730
39Abnormality of urine glucose concentration (HP:0011016)2.99097187
40Glycosuria (HP:0003076)2.99097187
41Hypoglycemic coma (HP:0001325)2.93547840
42CNS demyelination (HP:0007305)2.90204208
43Myoglobinuria (HP:0002913)2.89333314
44Abnormality of fatty-acid metabolism (HP:0004359)2.87330407
45Exertional dyspnea (HP:0002875)2.81728898
46Hyperammonemia (HP:0001987)2.80711636
47Ketosis (HP:0001946)2.74505373
48Type I transferrin isoform profile (HP:0003642)2.72675737
49Rhabdomyolysis (HP:0003201)2.71301008
50Ketoacidosis (HP:0001993)2.70453211
51Congenital, generalized hypertrichosis (HP:0004540)2.69096613
52Ragged-red muscle fibers (HP:0003200)2.65807060
53Exercise-induced myalgia (HP:0003738)2.60099152
54Hyperglycinemia (HP:0002154)2.57602070
55Vomiting (HP:0002013)2.56508539
56Hyperglycinuria (HP:0003108)2.53959097
57Pallor (HP:0000980)2.53847773
58Generalized aminoaciduria (HP:0002909)2.51668506
59Exercise-induced muscle cramps (HP:0003710)2.51217633
60Hyperphosphaturia (HP:0003109)2.51024332
61Respiratory difficulties (HP:0002880)2.50304740
62Pheochromocytoma (HP:0002666)2.49164753
63Neuroendocrine neoplasm (HP:0100634)2.49079087
64Conjunctival hamartoma (HP:0100780)2.47816625
65Lipoatrophy (HP:0100578)2.47493914
66Abnormality of glycine metabolism (HP:0010895)2.43244932
67Abnormality of serine family amino acid metabolism (HP:0010894)2.43244932
68Abnormality of renal resorption (HP:0011038)2.42971616
69Aplastic anemia (HP:0001915)2.41872727
70Metabolic acidosis (HP:0001942)2.35349375
71Abnormal hemoglobin (HP:0011902)2.34913345
72Methylmalonic aciduria (HP:0012120)2.29646657
73Atrial fibrillation (HP:0005110)2.28564277
74Intrahepatic cholestasis (HP:0001406)2.27990203
75Abnormality of the calf musculature (HP:0001430)2.25086068
76Myokymia (HP:0002411)2.24467210
77Syncope (HP:0001279)2.23710218
78Emotional lability (HP:0000712)2.23604523
79Dilated cardiomyopathy (HP:0001644)2.23320356
80Abnormality of midbrain morphology (HP:0002418)2.23174953
81Molar tooth sign on MRI (HP:0002419)2.23174953
82Muscle fiber splitting (HP:0003555)2.23078941
83Prolonged QT interval (HP:0001657)2.22055328
84Ventricular fibrillation (HP:0001663)2.20340497
85Nausea (HP:0002018)2.18320505
86Supraventricular tachycardia (HP:0004755)2.17189772
87Hypobetalipoproteinemia (HP:0003563)2.17097640
88Primary atrial arrhythmia (HP:0001692)2.14440600
89Aplasia/Hypoplasia of the sacrum (HP:0008517)2.14409530
90Oral leukoplakia (HP:0002745)2.13676961
91Abnormal protein glycosylation (HP:0012346)2.12185256
92Abnormal glycosylation (HP:0012345)2.12185256
93Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12185256
94Abnormal protein N-linked glycosylation (HP:0012347)2.12185256
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12051954
96Abnormality of alanine metabolism (HP:0010916)2.12051954
97Hyperalaninemia (HP:0003348)2.12051954
98Abnormal urine phosphate concentration (HP:0012599)2.09698330
99Supraventricular arrhythmia (HP:0005115)2.09647475
100Proximal tubulopathy (HP:0000114)2.09576009
101Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.07984056
102Macrocytic anemia (HP:0001972)2.07057665
103Right ventricular cardiomyopathy (HP:0011663)2.03513387
104Muscle stiffness (HP:0003552)2.03506033
105Abnormality of monocarboxylic acid metabolism (HP:0010996)2.02985067
106Abnormality of serum amino acid levels (HP:0003112)2.02296861
107Xanthomatosis (HP:0000991)1.99419321
108Testicular atrophy (HP:0000029)1.99391991
109Pancreatic cysts (HP:0001737)1.99351743
110Gliosis (HP:0002171)1.98703359
111X-linked dominant inheritance (HP:0001423)1.97786531
112Prolonged partial thromboplastin time (HP:0003645)1.97256483
113Pancreatic fibrosis (HP:0100732)1.96267836
114Medial flaring of the eyebrow (HP:0010747)1.95126060
115Abnormality of placental membranes (HP:0011409)1.94574597
116Amniotic constriction ring (HP:0009775)1.94574597
117Abnormality of cells of the erythroid lineage (HP:0012130)1.93692234
118Delayed CNS myelination (HP:0002188)1.93303867
119Esophageal neoplasm (HP:0100751)1.92687016
120Neoplasm of head and neck (HP:0012288)1.92687016
121Progressive external ophthalmoplegia (HP:0000590)1.92680607
122Methylmalonic acidemia (HP:0002912)1.89727670
123Ileus (HP:0002595)1.89092287
124Pancytopenia (HP:0001876)1.88021538
125Reduced antithrombin III activity (HP:0001976)1.86717648
126Renal tubular dysfunction (HP:0000124)1.85480548
127Abnormality of the anterior horn cell (HP:0006802)1.84824008
128Degeneration of anterior horn cells (HP:0002398)1.84824008
129Blindness (HP:0000618)1.84662677
130Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.81582312
131Sclerocornea (HP:0000647)1.79973501
132Opisthotonus (HP:0002179)1.73971623
133True hermaphroditism (HP:0010459)1.71455367
134Abnormality of methionine metabolism (HP:0010901)1.70981151
135Microvesicular hepatic steatosis (HP:0001414)1.67315616
136Microretrognathia (HP:0000308)1.61911231
137Abnormality of aspartate family amino acid metabolism (HP:0010899)1.61786786
138Hypothermia (HP:0002045)1.61139427
139Sparse eyelashes (HP:0000653)1.60283724
140Aplasia/hypoplasia of the uterus (HP:0008684)1.56665207
141Cerebral hypomyelination (HP:0006808)1.55900255
142Nephronophthisis (HP:0000090)1.55433113
143Megaloblastic anemia (HP:0001889)1.54156254
144Abnormal pupillary function (HP:0007686)1.50962889
145Concave nail (HP:0001598)1.50032690
146Renal cortical cysts (HP:0000803)1.49285768

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.36550627
2BCKDK4.57673439
3NME24.11995871
4TLK13.64921456
5MYLK3.61336694
6NME13.57685664
7OBSCN2.88314437
8LMTK22.78639088
9EIF2AK12.61916481
10PDK42.39229134
11PDK32.39229134
12STK162.36433284
13PBK2.27024903
14WNK42.26496796
15STK392.09147907
16PHKG12.01439436
17PHKG22.01439436
18TTN1.76170158
19PIK3CA1.74341458
20CDC71.72331428
21NUAK11.59056140
22DAPK31.57797701
23PINK11.54713732
24GRK71.53485769
25MAP3K111.50516071
26BUB11.49619903
27PIM21.46450681
28MAP4K21.45727660
29MUSK1.45251969
30MAP3K121.40630866
31STK38L1.40367681
32PDK21.39350146
33ARAF1.37837706
34ABL21.37360212
35TESK21.37276555
36CAMK2D1.34886068
37LIMK11.31532242
38BRAF1.30791428
39MST1R1.25936392
40IRAK31.25408407
41GRK11.24371641
42KDR1.22952423
43BMPR1B1.22868114
44CASK1.21609557
45NEK11.16856270
46CDK191.14530676
47CDK81.13642149
48CAMK2G1.10229995
49ILK1.09306637
50WNK31.09122778
51CSNK1G31.09037399
52TIE11.06585055
53OXSR11.06295678
54CCNB11.04039054
55TAF10.96161530
56PLK40.94757686
57MAP2K20.93301851
58PLK30.92694430
59CSNK1G20.92072807
60AURKB0.91301959
61TESK10.90135667
62RPS6KA50.89272164
63VRK10.87081046
64CSNK1G10.84899849
65STK240.84450371
66PLK10.83251215
67PIK3CG0.81647410
68PKN10.76906405
69DAPK10.73097031
70CAMK2B0.73056666
71CAMK2A0.72947045
72CSNK1A1L0.69608579
73BRSK10.69365089
74MAP2K60.69339855
75NEK90.68825059
76MST40.68440184
77EPHB20.66914963
78IRAK10.65705165
79CHEK20.65281929
80ADRBK10.62183336
81TTK0.61931052
82SCYL20.60689325
83PAK30.58986849
84LRRK20.58879409
85AURKA0.56802960
86PRKCI0.56467214
87PRKACA0.56456626
88ZAK0.53525183
89ROCK10.51707880
90EIF2AK30.50842733
91MAPK120.49965360
92IRAK20.49743098
93BRSK20.49573981
94PRKG20.48207910
95GRK50.47620244
96PRKCE0.46115441
97MARK10.45034563
98MAP2K40.44963396
99ATR0.44857455
100MAPK150.44535749
101CSNK2A10.44323646
102WEE10.43275841
103DMPK0.42279268
104PRKD10.41171734
105ROCK20.40545584
106MAPK40.39913908
107CSNK1A10.39807192
108DYRK30.39222226
109MAPKAPK30.37797409
110ADRBK20.37605754
111PRKACG0.37322412
112DYRK20.37143149
113CDC42BPA0.36976198
114PAK10.36468698
115MAP3K50.36453674
116MAP2K70.35468338
117EIF2AK20.35155504
118CSNK2A20.34576476
119PNCK0.34549384
120CSNK1E0.34029650
121BCR0.33934410
122TRIM280.33328907
123SRPK10.33110041
124MINK10.32949111
125RPS6KC10.32367310
126RPS6KL10.32367310
127MAPK130.30905605
128MAP3K40.30520856
129RPS6KB20.30216689
130PRKCA0.29685221
131CAMK10.29136602
132STK40.28946134
133INSRR0.28349316
134PRKACB0.27606958
135PRKCG0.26558856
136PRKAA20.24904979
137ERN10.24592589
138MAPKAPK50.24323382
139MAPK110.23113857
140PTK2B0.23000548
141PRKCD0.22653210
142RPS6KA60.22199191

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001905.10033645
2Parkinsons disease_Homo sapiens_hsa050124.49253666
3Alzheimers disease_Homo sapiens_hsa050103.22248553
4Huntingtons disease_Homo sapiens_hsa050163.06101405
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.03361698
6* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.01743482
7Ribosome_Homo sapiens_hsa030102.74226551
8* Cardiac muscle contraction_Homo sapiens_hsa042602.62443641
9Propanoate metabolism_Homo sapiens_hsa006402.45428268
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.37948829
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.30596275
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27845746
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.27137070
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23985411
15Fatty acid degradation_Homo sapiens_hsa000712.09436061
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03077883
17Sulfur metabolism_Homo sapiens_hsa009202.00776004
18Pyruvate metabolism_Homo sapiens_hsa006201.98698104
19DNA replication_Homo sapiens_hsa030301.95799307
20Butanoate metabolism_Homo sapiens_hsa006501.87298742
21Carbon metabolism_Homo sapiens_hsa012001.86744246
22Mismatch repair_Homo sapiens_hsa034301.85297940
23Proteasome_Homo sapiens_hsa030501.80695032
24Fatty acid elongation_Homo sapiens_hsa000621.69189489
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.65588347
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60437835
27Sulfur relay system_Homo sapiens_hsa041221.53883260
28Peroxisome_Homo sapiens_hsa041461.48403165
29Protein export_Homo sapiens_hsa030601.48209684
30Tryptophan metabolism_Homo sapiens_hsa003801.47212549
31Nucleotide excision repair_Homo sapiens_hsa034201.46796409
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45957254
33Fatty acid metabolism_Homo sapiens_hsa012121.43887717
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42988639
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.41580475
36Arginine biosynthesis_Homo sapiens_hsa002201.31621082
37Base excision repair_Homo sapiens_hsa034101.28565566
38Spliceosome_Homo sapiens_hsa030401.27472455
39beta-Alanine metabolism_Homo sapiens_hsa004101.23153902
40Phenylalanine metabolism_Homo sapiens_hsa003601.20859743
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19532082
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18318767
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16812846
44Folate biosynthesis_Homo sapiens_hsa007901.13620312
45Biosynthesis of amino acids_Homo sapiens_hsa012301.12339667
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11033472
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09288261
48PPAR signaling pathway_Homo sapiens_hsa033201.08446960
49Arginine and proline metabolism_Homo sapiens_hsa003301.08129272
50RNA polymerase_Homo sapiens_hsa030201.06881410
51Tyrosine metabolism_Homo sapiens_hsa003501.06193515
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.05851047
53Chemical carcinogenesis_Homo sapiens_hsa052041.05672021
54Glutathione metabolism_Homo sapiens_hsa004800.99697909
55Fat digestion and absorption_Homo sapiens_hsa049750.98053397
56Basal transcription factors_Homo sapiens_hsa030220.97908101
57* Metabolic pathways_Homo sapiens_hsa011000.96822808
58Histidine metabolism_Homo sapiens_hsa003400.93799362
59RNA degradation_Homo sapiens_hsa030180.93410725
60Fanconi anemia pathway_Homo sapiens_hsa034600.89300031
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.86968659
62Starch and sucrose metabolism_Homo sapiens_hsa005000.80845937
63Retinol metabolism_Homo sapiens_hsa008300.80393600
64Pentose phosphate pathway_Homo sapiens_hsa000300.79723559
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.75952889
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.75246767
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75158809
68Pyrimidine metabolism_Homo sapiens_hsa002400.72646321
69RNA transport_Homo sapiens_hsa030130.72123974
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70243116
71Linoleic acid metabolism_Homo sapiens_hsa005910.68116959
72Fructose and mannose metabolism_Homo sapiens_hsa000510.64385119
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62368158
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62092826
75Phototransduction_Homo sapiens_hsa047440.60906049
76Complement and coagulation cascades_Homo sapiens_hsa046100.60392996
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59940541
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59933405
79Galactose metabolism_Homo sapiens_hsa000520.58118833
80Arachidonic acid metabolism_Homo sapiens_hsa005900.53256534
81Collecting duct acid secretion_Homo sapiens_hsa049660.50386658
82Steroid biosynthesis_Homo sapiens_hsa001000.48309526
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.46632597
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43815076
85Selenocompound metabolism_Homo sapiens_hsa004500.42719757
86Systemic lupus erythematosus_Homo sapiens_hsa053220.42218963
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41129590
88N-Glycan biosynthesis_Homo sapiens_hsa005100.40747820
89Dilated cardiomyopathy_Homo sapiens_hsa054140.39928197
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39825757
91Bile secretion_Homo sapiens_hsa049760.39473209
92Vitamin B6 metabolism_Homo sapiens_hsa007500.35231592
93Purine metabolism_Homo sapiens_hsa002300.34365676
94Vibrio cholerae infection_Homo sapiens_hsa051100.34108859
95One carbon pool by folate_Homo sapiens_hsa006700.31078877
96Glycerolipid metabolism_Homo sapiens_hsa005610.29501784
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26993283
98Caffeine metabolism_Homo sapiens_hsa002320.26478141
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26205974
100Nitrogen metabolism_Homo sapiens_hsa009100.25178512
101Non-homologous end-joining_Homo sapiens_hsa034500.24953236
102Nicotine addiction_Homo sapiens_hsa050330.23416028
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22539848
104Synaptic vesicle cycle_Homo sapiens_hsa047210.18910171
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.17363203
106Vitamin digestion and absorption_Homo sapiens_hsa049770.16294500
107Homologous recombination_Homo sapiens_hsa034400.15967196
108Ether lipid metabolism_Homo sapiens_hsa005650.06793899
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.05133499
110ABC transporters_Homo sapiens_hsa020100.04826564
111Staphylococcus aureus infection_Homo sapiens_hsa051500.01788675
112Mineral absorption_Homo sapiens_hsa04978-0.0993379
113Pancreatic secretion_Homo sapiens_hsa04972-0.0913284
114Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0661779
115Regulation of autophagy_Homo sapiens_hsa04140-0.0586436
116Glucagon signaling pathway_Homo sapiens_hsa04922-0.0543358
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0520999
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.0206292
119Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0082983

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