UPK1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.39350846
2cilium movement (GO:0003341)7.39884225
3diterpenoid biosynthetic process (GO:0016102)7.29460246
4cilium or flagellum-dependent cell motility (GO:0001539)7.05168425
5epithelial cilium movement (GO:0003351)6.95310889
6xenobiotic catabolic process (GO:0042178)6.83315055
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.72705418
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.40590524
9motile cilium assembly (GO:0044458)6.16130644
10regulation of skeletal muscle contraction (GO:0014819)6.05186105
11plasma membrane repair (GO:0001778)6.02425569
12axoneme assembly (GO:0035082)5.59240704
13terpenoid biosynthetic process (GO:0016114)5.56385146
14retinoic acid metabolic process (GO:0042573)5.11133051
15response to nitrosative stress (GO:0051409)5.02718173
16hypotonic response (GO:0006971)4.90434634
17pyrimidine dimer repair (GO:0006290)4.69800600
18hemidesmosome assembly (GO:0031581)4.64221674
19branching involved in prostate gland morphogenesis (GO:0060442)4.56854838
20lateral sprouting from an epithelium (GO:0060601)4.50181586
21interferon-gamma secretion (GO:0072643)4.47309874
22molting cycle (GO:0042303)4.45928652
23hair cycle (GO:0042633)4.45928652
24epithelial cell differentiation involved in prostate gland development (GO:0060742)4.45317298
25atrioventricular valve morphogenesis (GO:0003181)4.42001533
26negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.41782191
27O-glycan processing (GO:0016266)4.35355234
28regulation of cardioblast differentiation (GO:0051890)4.34017741
29glutathione derivative metabolic process (GO:1901685)4.27575125
30glutathione derivative biosynthetic process (GO:1901687)4.27575125
31extracellular fibril organization (GO:0043206)4.26681461
32pyrimidine-containing compound transmembrane transport (GO:0072531)4.25683278
33endocardial cushion development (GO:0003197)4.22080450
34L-ascorbic acid metabolic process (GO:0019852)4.20690705
35lung lobe morphogenesis (GO:0060463)4.15964538
36establishment of planar polarity (GO:0001736)4.15441920
37establishment of tissue polarity (GO:0007164)4.15441920
38ethanol oxidation (GO:0006069)4.09575983
39prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.01938614
40left/right pattern formation (GO:0060972)3.89445403
41surfactant homeostasis (GO:0043129)3.89406260
42regulation of secondary heart field cardioblast proliferation (GO:0003266)3.88764234
43regulation of cardioblast proliferation (GO:0003264)3.88764234
44extracellular negative regulation of signal transduction (GO:1900116)3.78778995
45extracellular regulation of signal transduction (GO:1900115)3.78778995
46bundle of His cell to Purkinje myocyte communication (GO:0086069)3.76920413
47desmosome organization (GO:0002934)3.71653495
48cilium organization (GO:0044782)3.70114613
49gas transport (GO:0015669)3.69806805
50retinol metabolic process (GO:0042572)3.68866932
51regulation of cilium movement (GO:0003352)3.61714573
52renal absorption (GO:0070293)3.60108220
53fibril organization (GO:0097435)3.59244294
54artery development (GO:0060840)3.58289696
55cilium assembly (GO:0042384)3.56814127
56potassium ion homeostasis (GO:0055075)3.52963109
57cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.51873582
58sequestering of extracellular ligand from receptor (GO:0035581)3.50050615
59ethanol metabolic process (GO:0006067)3.47742513
60natural killer cell mediated cytotoxicity (GO:0042267)3.47190931
61natural killer cell mediated immunity (GO:0002228)3.47190931
62epithelial cell-cell adhesion (GO:0090136)3.39266878
63microtubule bundle formation (GO:0001578)3.37965679
64intraciliary transport (GO:0042073)3.33664599
65negative regulation of cardiac muscle tissue growth (GO:0055022)3.33507476
66negative regulation of heart growth (GO:0061117)3.33507476
67multicellular organismal water homeostasis (GO:0050891)3.30322109
68positive regulation of gastrulation (GO:2000543)3.29639271
69fucose catabolic process (GO:0019317)3.29254824
70L-fucose metabolic process (GO:0042354)3.29254824
71L-fucose catabolic process (GO:0042355)3.29254824
72keratinocyte differentiation (GO:0030216)3.24907714
73pancreas development (GO:0031016)3.24753947
74prostate gland epithelium morphogenesis (GO:0060740)3.24271537
75left/right axis specification (GO:0070986)3.22734308
76negative regulation of kidney development (GO:0090185)3.22661276
77nephron epithelium morphogenesis (GO:0072088)3.22601940
78nephron tubule morphogenesis (GO:0072078)3.22601940
79UDP-N-acetylglucosamine metabolic process (GO:0006047)3.20378490
80retinal metabolic process (GO:0042574)3.19031782
81establishment of skin barrier (GO:0061436)3.18294123
82protein O-linked glycosylation (GO:0006493)3.16980977
83glomerular epithelial cell development (GO:0072310)3.16111740
84establishment of apical/basal cell polarity (GO:0035089)3.13157600
85hormone catabolic process (GO:0042447)3.10078013
86flavonoid metabolic process (GO:0009812)3.09056893
87extracellular matrix assembly (GO:0085029)3.07048475
88positive regulation of osteoblast proliferation (GO:0033690)3.06360129
89photoreceptor cell maintenance (GO:0045494)3.05608426
90apoptotic cell clearance (GO:0043277)3.04661063
91cilium morphogenesis (GO:0060271)3.03135103
92regulation of ruffle assembly (GO:1900027)3.01767251
93regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.00444831
94metanephric mesenchyme development (GO:0072075)2.99874189
95epidermis development (GO:0008544)2.99047967
96lung epithelium development (GO:0060428)2.97980590
97negative regulation of chondrocyte differentiation (GO:0032331)2.96540666
98positive regulation of transforming growth factor beta production (GO:0071636)2.94822761
99regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.93639974
100water homeostasis (GO:0030104)2.92140620
101Golgi transport vesicle coating (GO:0048200)2.91197864
102COPI coating of Golgi vesicle (GO:0048205)2.91197864
103chemical homeostasis within a tissue (GO:0048875)2.90757278
104regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.90515742
105L-serine transport (GO:0015825)2.90278374
106mesenchyme morphogenesis (GO:0072132)2.89846981
107keratinocyte development (GO:0003334)2.89796695
108mesonephros development (GO:0001823)2.89505653
109endothelial cell morphogenesis (GO:0001886)2.88602257
110cell differentiation involved in metanephros development (GO:0072202)2.87824340
111positive regulation of steroid biosynthetic process (GO:0010893)2.87038140
112branching involved in salivary gland morphogenesis (GO:0060445)2.86455863
113positive regulation of embryonic development (GO:0040019)2.84678108
114protein localization to cilium (GO:0061512)2.84409874
115cornea development in camera-type eye (GO:0061303)2.82845943
116response to follicle-stimulating hormone (GO:0032354)2.82691689
117pattern specification involved in kidney development (GO:0061004)2.82506530
118primary alcohol metabolic process (GO:0034308)2.81539109
119mannose metabolic process (GO:0006013)2.80468851
120cell proliferation involved in metanephros development (GO:0072203)2.80344544
121negative regulation of neurological system process (GO:0031645)2.80031662
122positive regulation of hormone biosynthetic process (GO:0046886)2.79938840
123ventricular septum development (GO:0003281)2.78272246
124relaxation of cardiac muscle (GO:0055119)2.78108304
125mesenchymal cell differentiation involved in kidney development (GO:0072161)2.77599498
126mesenchymal cell differentiation involved in renal system development (GO:2001012)2.77599498
127regulation of heart rate by cardiac conduction (GO:0086091)2.77363016
128atrial septum morphogenesis (GO:0060413)2.77201556
129striated muscle atrophy (GO:0014891)2.75121064
130sodium ion homeostasis (GO:0055078)2.74800053
131regulation of water loss via skin (GO:0033561)2.74648251
132positive regulation of actin filament depolymerization (GO:0030836)2.74484593
133cell projection assembly (GO:0030031)2.74379288
134embryonic foregut morphogenesis (GO:0048617)2.74043824
135ventricular cardiac muscle cell action potential (GO:0086005)2.73529140
136cellular component assembly involved in morphogenesis (GO:0010927)2.69456239
137regulation of phospholipase A2 activity (GO:0032429)2.69275572
138regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.67900300
139regulation of metalloenzyme activity (GO:0048552)2.67401831
140positive regulation of glomerulus development (GO:0090193)2.66798037
141keratinization (GO:0031424)2.66788189
142establishment of monopolar cell polarity (GO:0061162)2.66678394
143establishment or maintenance of monopolar cell polarity (GO:0061339)2.66678394
144exogenous drug catabolic process (GO:0042738)2.65004272
145regulation of transforming growth factor beta2 production (GO:0032909)2.64918178
146intestinal epithelial cell development (GO:0060576)2.64581796
147response to water (GO:0009415)2.63529218
148regulation of hippo signaling (GO:0035330)2.62635390
149regulation of transforming growth factor beta1 production (GO:0032908)2.62186266
150regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.62184198
151positive regulation of protein kinase C signaling (GO:0090037)2.61825527
152regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.61622006
153regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.61406197
154maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.60377548
155regulation of heart morphogenesis (GO:2000826)2.59867247
156pharyngeal system development (GO:0060037)2.58939968
157respiratory tube development (GO:0030323)2.57142063
158positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.55586227
159cell adhesion mediated by integrin (GO:0033627)2.55509883
160regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.52647524
161primary alcohol catabolic process (GO:0034310)2.52311729
162peptide catabolic process (GO:0043171)2.51256842
163endocardial cushion morphogenesis (GO:0003203)2.49043113
164fibroblast migration (GO:0010761)2.48675155
165vitamin transmembrane transport (GO:0035461)2.46836084
166negative regulation of fatty acid transport (GO:2000192)2.46824619
167cellular glucuronidation (GO:0052695)2.46494082
168cytoskeletal anchoring at plasma membrane (GO:0007016)2.46299771
169uronic acid metabolic process (GO:0006063)2.45866232
170glucuronate metabolic process (GO:0019585)2.45866232
171cell-substrate junction assembly (GO:0007044)2.45045155
172heart valve morphogenesis (GO:0003179)2.44952648
173lateral ventricle development (GO:0021670)2.43257481
174gland morphogenesis (GO:0022612)2.43080119
175serine transport (GO:0032329)2.42155317
176lung vasculature development (GO:0060426)2.40548876
177camera-type eye morphogenesis (GO:0048593)2.39804317
178regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.39460597
179cellular response to arsenic-containing substance (GO:0071243)2.38663355
180positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.37221540
181water transport (GO:0006833)2.36189530
182relaxation of muscle (GO:0090075)2.35149065
183positive regulation of wound healing (GO:0090303)2.30369845
184outflow tract septum morphogenesis (GO:0003148)2.30270900
185establishment or maintenance of apical/basal cell polarity (GO:0035088)2.28386287
186establishment or maintenance of bipolar cell polarity (GO:0061245)2.28386287
187protein retention in ER lumen (GO:0006621)2.28132854
188cardiac septum development (GO:0003279)2.27819682
189one-carbon compound transport (GO:0019755)10.1062635

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.00598099
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.86298017
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.85743718
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.69531062
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.56586957
6CLOCK_20551151_ChIP-Seq_293T_Human3.21423501
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.17743972
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.86177021
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.82845602
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.78564111
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.46227603
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.34992950
13SOX2_27498859_Chip-Seq_STOMACH_Mouse2.30227201
14SOX2_20726797_ChIP-Seq_SW620_Human2.17417899
15CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.09471184
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.08327794
17PPAR_26484153_Chip-Seq_NCI-H1993_Human2.02734244
18CDX2_20551321_ChIP-Seq_CACO-2_Human2.00944432
19ZNF274_21170338_ChIP-Seq_K562_Hela1.98672893
20* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.92455315
21* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.92455315
22NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.88075614
23NRF2_20460467_ChIP-Seq_MEFs_Mouse1.88075614
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83611517
25EP300_21415370_ChIP-Seq_HL-1_Mouse1.82035083
26ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.81890252
27ZNF263_19887448_ChIP-Seq_K562_Human1.81142962
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.80715014
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80049747
30* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78982541
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.77916779
32FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.77551856
33SOX9_24532713_ChIP-Seq_HFSC_Mouse1.76421835
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76355939
35GBX2_23144817_ChIP-Seq_PC3_Human1.74459323
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74024148
37VDR_22108803_ChIP-Seq_LS180_Human1.72618717
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.70618512
39CJUN_26792858_Chip-Seq_BT549_Human1.67653828
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.66070979
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64984571
42GATA4_25053715_ChIP-Seq_YYC3_Human1.63717923
43SALL4_18804426_ChIP-ChIP_XEN_Mouse1.63504044
44TAF15_26573619_Chip-Seq_HEK293_Human1.63135229
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.60621812
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60602922
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.59395184
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.55349020
49AHR_22903824_ChIP-Seq_MCF-7_Human1.55194588
50FUS_26573619_Chip-Seq_HEK293_Human1.53485327
51TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52916178
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.51727173
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.51551602
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49480692
55TP53_16413492_ChIP-PET_HCT116_Human1.48679464
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45157921
57SMAD4_21799915_ChIP-Seq_A2780_Human1.44275155
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42120072
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.41543171
60AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.41057712
61ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.39800751
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.39746038
63* SMAD3_21741376_ChIP-Seq_HESCs_Human1.39536421
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39484364
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39369994
66CBP_20019798_ChIP-Seq_JUKART_Human1.39369994
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37848805
68* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36373898
69LXR_22158963_ChIP-Seq_LIVER_Mouse1.35924913
70RUNX1_27514584_Chip-Seq_MCF-7_Human1.35707176
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.35033592
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34075530
73EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33061841
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.32237243
75EWS_26573619_Chip-Seq_HEK293_Human1.31918058
76P300_19829295_ChIP-Seq_ESCs_Human1.31229968
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30219450
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30140808
79GATA3_24758297_ChIP-Seq_MCF-7_Human1.30120802
80ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.30083802
81FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.29870939
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28840017
83CDX2_22108803_ChIP-Seq_LS180_Human1.26813904
84TCF4_22108803_ChIP-Seq_LS180_Human1.25957997
85RACK7_27058665_Chip-Seq_MCF-7_Human1.25475100
86* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25331367
87* KLF5_25053715_ChIP-Seq_YYC3_Human1.24951491
88GATA6_25053715_ChIP-Seq_YYC3_Human1.24421276
89TP53_18474530_ChIP-ChIP_U2OS_Human1.23379452
90RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22697841
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21532262
92ER_23166858_ChIP-Seq_MCF-7_Human1.21353285
93BCAT_22108803_ChIP-Seq_LS180_Human1.20935095
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20241537
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18594078
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18331299
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17481675
98DROSHA_22980978_ChIP-Seq_HELA_Human1.16998442
99FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16690394
100FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16669310
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.16371272
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.15630198
103AR_25329375_ChIP-Seq_VCAP_Human1.14824697
104SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14376398
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14140615
106* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13301554
107BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11223684
108* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11131026
109P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09365446
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09070545
111STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09034030
112EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07828326
113ETV1_20927104_ChIP-Seq_GIST48_Human1.07812701
114TCF4_18268006_ChIP-ChIP_LS174T_Human1.07143831
115NFE2_27457419_Chip-Seq_LIVER_Mouse1.05976394
116TCF4_23295773_ChIP-Seq_U87_Human1.05857959
117* SMAD4_21741376_ChIP-Seq_HESCs_Human1.05535220
118PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05053028
119PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.04414373
120RXR_22158963_ChIP-Seq_LIVER_Mouse1.03764093
121JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03702109
122STAT3_23295773_ChIP-Seq_U87_Human1.03617455
123CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03373117
124BRD4_25478319_ChIP-Seq_HGPS_Human1.01597776
125TBX20_22328084_ChIP-Seq_HEART_Mouse1.01487217
126TBX20_22080862_ChIP-Seq_HEART_Mouse1.01487217
127EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01468353
128CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01018124
129* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00872986
130* FOXA1_25329375_ChIP-Seq_VCAP_Human1.00872986
131SMAD4_21741376_ChIP-Seq_EPCs_Human1.00634139
132TP63_23658742_ChIP-Seq_EP156T_Human0.98871991
133Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97081595
134FOXA2_19822575_ChIP-Seq_HepG2_Human0.96723321
135RUNX2_22187159_ChIP-Seq_PCA_Human0.96671075
136WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94970957
137POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94772305
138UBF1/2_26484160_Chip-Seq_HMECs_Human0.93747397
139SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93569153
140CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92419006
141ISL1_27105846_Chip-Seq_CPCs_Mouse0.91846295
142TBL1_22424771_ChIP-Seq_293T_Human0.91648478
143FOXA1_25552417_ChIP-Seq_VCAP_Human0.91502369
144WT1_19549856_ChIP-ChIP_CCG9911_Human0.91488611
145CBX2_22325352_ChIP-Seq_293T-Rex_Human0.91405869
146* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90661735
147JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88132756
148KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.86701834
149KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86701834
150KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86701834
151RXR_22108803_ChIP-Seq_LS180_Human0.85373818
152GATA1_22025678_ChIP-Seq_K562_Human0.83828801
153ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83741991
154NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83407359
155AR_21909140_ChIP-Seq_LNCAP_Human0.79045025

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000516_abnormal_urinary_system5.89650150
2MP0005367_renal/urinary_system_phenotyp5.89650150
3MP0010386_abnormal_urinary_bladder4.98166690
4MP0000537_abnormal_urethra_morphology3.16285463
5MP0010234_abnormal_vibrissa_follicle3.10419900
6MP0000534_abnormal_ureter_morphology2.94605452
7MP0003950_abnormal_plasma_membrane2.90100795
8MP0002282_abnormal_trachea_morphology2.81628737
9MP0008875_abnormal_xenobiotic_pharmacok2.74006347
10MP0003566_abnormal_cell_adhesion2.65387214
11MP0001984_abnormal_olfaction2.58514253
12MP0002254_reproductive_system_inflammat2.45585218
13MP0003300_gastrointestinal_ulcer2.44120946
14MP0001756_abnormal_urination2.23918358
15MP0010771_integument_phenotype2.09042301
16MP0003195_calcinosis2.01333233
17MP0001958_emphysema1.94509195
18MP0003941_abnormal_skin_development1.92961184
19MP0004272_abnormal_basement_membrane1.92305776
20MP0009384_cardiac_valve_regurgitation1.89774850
21MP0008438_abnormal_cutaneous_collagen1.86009677
22MP0006054_spinal_hemorrhage1.84159214
23MP0004264_abnormal_extraembryonic_tissu1.81269339
24MP0003705_abnormal_hypodermis_morpholog1.79554861
25MP0000566_synostosis1.78127938
26MP0000579_abnormal_nail_morphology1.77037697
27MP0004133_heterotaxia1.76573012
28MP0003890_abnormal_embryonic-extraembry1.71773025
29MP0009053_abnormal_anal_canal1.70326539
30MP0005501_abnormal_skin_physiology1.69540145
31MP0005275_abnormal_skin_tensile1.65335809
32MP0002166_altered_tumor_susceptibility1.64565983
33MP0002653_abnormal_ependyma_morphology1.64413412
34MP0009780_abnormal_chondrocyte_physiolo1.62997367
35MP0008872_abnormal_physiological_respon1.62548259
36MP0002876_abnormal_thyroid_physiology1.61280098
37MP0000427_abnormal_hair_cycle1.59333049
38MP0010368_abnormal_lymphatic_system1.57401016
39MP0005023_abnormal_wound_healing1.57373702
40MP0001346_abnormal_lacrimal_gland1.56576280
41MP0002160_abnormal_reproductive_system1.54567154
42MP0004142_abnormal_muscle_tone1.52418259
43MP0003136_yellow_coat_color1.49859753
44MP0000647_abnormal_sebaceous_gland1.49859609
45MP0000762_abnormal_tongue_morphology1.48654735
46MP0000538_abnormal_urinary_bladder1.47083392
47MP0004019_abnormal_vitamin_homeostasis1.46372884
48MP0005248_abnormal_Harderian_gland1.43270807
49MP0010678_abnormal_skin_adnexa1.42118176
50MP0000467_abnormal_esophagus_morphology1.39582064
51MP0003828_pulmonary_edema1.39444217
52MP0005389_reproductive_system_phenotype1.36940186
53MP0000465_gastrointestinal_hemorrhage1.30810962
54MP0002295_abnormal_pulmonary_circulatio1.28265993
55MP0010352_gastrointestinal_tract_polyps1.25061141
56MP0002909_abnormal_adrenal_gland1.23846195
57MP0005503_abnormal_tendon_morphology1.23250251
58MP0000613_abnormal_salivary_gland1.21981474
59MP0002139_abnormal_hepatobiliary_system1.21047571
60MP0003186_abnormal_redox_activity1.20419444
61MP0001243_abnormal_dermal_layer1.19280661
62MP0005164_abnormal_response_to1.18756579
63MP0002277_abnormal_respiratory_mucosa1.15829648
64MP0000377_abnormal_hair_follicle1.14018634
65MP0002006_tumorigenesis1.13967140
66MP0000003_abnormal_adipose_tissue1.09938155
67MP0001765_abnormal_ion_homeostasis1.09125683
68MP0002060_abnormal_skin_morphology1.09012208
69MP0010030_abnormal_orbit_morphology1.08420209
70MP0003453_abnormal_keratinocyte_physiol1.07518640
71MP0005409_darkened_coat_color1.07074115
72MP0005310_abnormal_salivary_gland1.06554949
73MP0003385_abnormal_body_wall1.06510168
74MP0002168_other_aberrant_phenotype1.05293678
75MP0000462_abnormal_digestive_system1.04669717
76MP0002009_preneoplasia1.04177078
77MP0002877_abnormal_melanocyte_morpholog1.03282940
78MP0003937_abnormal_limbs/digits/tail_de1.01701143
79MP0005394_taste/olfaction_phenotype1.01332802
80MP0005499_abnormal_olfactory_system1.01332802
81MP0005253_abnormal_eye_physiology1.00950309
82MP0002098_abnormal_vibrissa_morphology1.00473032
83MP0000383_abnormal_hair_follicle0.99820800
84MP0004885_abnormal_endolymph0.96549060
85MP0001919_abnormal_reproductive_system0.95583041
86MP0005166_decreased_susceptibility_to0.95134328
87MP0003115_abnormal_respiratory_system0.94487509
88MP0003786_premature_aging0.93595144
89MP0001191_abnormal_skin_condition0.93589355
90MP0003638_abnormal_response/metabolism_0.92961166
91MP0000767_abnormal_smooth_muscle0.92076291
92MP0000639_abnormal_adrenal_gland0.91795990
93MP0003942_abnormal_urinary_system0.91435910
94MP0009764_decreased_sensitivity_to0.91148737
95MP0001270_distended_abdomen0.90995593
96MP0005083_abnormal_biliary_tract0.89639923
97MP0009643_abnormal_urine_homeostasis0.89144910
98MP0005330_cardiomyopathy0.88601095
99MP0005388_respiratory_system_phenotype0.87781099
100MP0002133_abnormal_respiratory_system0.87781099
101MP0009250_abnormal_appendicular_skeleto0.86923892
102MP0005085_abnormal_gallbladder_physiolo0.86736499
103MP0001873_stomach_inflammation0.86220892
104MP0002136_abnormal_kidney_physiology0.86033871
105MP0004883_abnormal_blood_vessel0.85400034
106MP0002796_impaired_skin_barrier0.84872599
107MP0001664_abnormal_digestion0.84756343
108MP0005171_absent_coat_pigmentation0.83178938
109MP0004782_abnormal_surfactant_physiolog0.82377970
110MP0002234_abnormal_pharynx_morphology0.81038403
111MP0005165_increased_susceptibility_to0.80926007
112MP0004134_abnormal_chest_morphology0.80719362
113MP0003806_abnormal_nucleotide_metabolis0.79777567
114MP0004043_abnormal_pH_regulation0.78423514
115MP0001849_ear_inflammation0.78314678
116MP0003878_abnormal_ear_physiology0.77100896
117MP0005377_hearing/vestibular/ear_phenot0.77100896
118MP0005395_other_phenotype0.77026282
119MP0003315_abnormal_perineum_morphology0.76222665
120MP0002233_abnormal_nose_morphology0.75867825
121MP0000343_altered_response_to0.75091450
122MP0003936_abnormal_reproductive_system0.75026814
123MP0003119_abnormal_digestive_system0.74652247
124MP0003091_abnormal_cell_migration0.73445698
125MP0008789_abnormal_olfactory_epithelium0.72634312
126MP0003075_altered_response_to0.72446969
127MP0002135_abnormal_kidney_morphology0.72432470
128MP0001216_abnormal_epidermal_layer0.70619337
129MP0001879_abnormal_lymphatic_vessel0.70597243
130MP0010630_abnormal_cardiac_muscle0.69503760
131MP0001764_abnormal_homeostasis0.69214637
132MP0009379_abnormal_foot_pigmentation0.68813633
133MP0005058_abnormal_lysosome_morphology0.68353131
134MP0000470_abnormal_stomach_morphology0.68066893
135MP0005187_abnormal_penis_morphology0.68065607
136MP0001485_abnormal_pinna_reflex0.67970774
137MP0002736_abnormal_nociception_after0.67339634
138MP0005408_hypopigmentation0.66419060
139MP0005508_abnormal_skeleton_morphology0.66367440
140MP0006138_congestive_heart_failure0.66315079
141MP0005365_abnormal_bile_salt0.66280776
142MP0002896_abnormal_bone_mineralization0.66276815
143MP0002925_abnormal_cardiovascular_devel0.65548437
144MP0000627_abnormal_mammary_gland0.65538796
145MP0004185_abnormal_adipocyte_glucose0.65319852
146MP0005551_abnormal_eye_electrophysiolog0.64746076
147MP0005620_abnormal_muscle_contractility0.64421356
148MP0002938_white_spotting0.63884220
149MP0003045_fibrosis0.63701537
150MP0005636_abnormal_mineral_homeostasis0.63694528
151MP0005647_abnormal_sex_gland0.63234421
152MP0002249_abnormal_larynx_morphology0.62721738
153MP0006072_abnormal_retinal_apoptosis0.62345313
154MP0005195_abnormal_posterior_eye0.62097466
155MP0002102_abnormal_ear_morphology0.61153783
156MP0000367_abnormal_coat/_hair0.59972248
157MP0003283_abnormal_digestive_organ0.58006634
158MP0000569_abnormal_digit_pigmentation0.55824822
159MP0008004_abnormal_stomach_pH0.55464419
160MP0006276_abnormal_autonomic_nervous0.55240397
161MP0005646_abnormal_pituitary_gland0.54921212

Predicted human phenotypes

RankGene SetZ-score
1Aortic aneurysm (HP:0004942)7.67237801
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.42196581
3Abnormal respiratory epithelium morphology (HP:0012253)6.70320011
4Abnormal respiratory motile cilium morphology (HP:0005938)6.70320011
5Abnormal respiratory motile cilium physiology (HP:0012261)6.64809515
6Absent/shortened dynein arms (HP:0200106)6.60784623
7Dynein arm defect of respiratory motile cilia (HP:0012255)6.60784623
8Rhinitis (HP:0012384)6.56551355
9Abnormal ciliary motility (HP:0012262)6.50809597
10Aortic dissection (HP:0002647)5.77611578
11Right ventricular cardiomyopathy (HP:0011663)5.32044810
12Chronic bronchitis (HP:0004469)5.22347142
13Bronchiectasis (HP:0002110)4.47742539
14Cerebral aneurysm (HP:0004944)4.41031739
15Ulnar bowing (HP:0003031)4.35004089
16Pancreatic fibrosis (HP:0100732)3.83977691
17Duplicated collecting system (HP:0000081)3.80651408
18Hypoplastic pelvis (HP:0008839)3.79659518
19True hermaphroditism (HP:0010459)3.72507825
20Tubular atrophy (HP:0000092)3.67933004
21Pancreatic cysts (HP:0001737)3.57060066
22Ankle contracture (HP:0006466)3.47269856
23Bronchomalacia (HP:0002780)3.41206051
24Abnormality of the renal collecting system (HP:0004742)3.40389547
25Dry hair (HP:0011359)3.29648255
26Abnormality of the 2nd finger (HP:0004100)3.27672485
27Hyperactive renin-angiotensin system (HP:0000841)3.24383674
28Nasal polyposis (HP:0100582)3.23520912
29Short hallux (HP:0010109)3.18289364
30Abnormal auditory evoked potentials (HP:0006958)3.11430901
31Entropion (HP:0000621)3.06825908
32Aneurysm (HP:0002617)3.02257174
33Bifid scrotum (HP:0000048)3.01287222
34Bowed forearm bones (HP:0003956)2.97585182
35Bowing of the arm (HP:0006488)2.97585182
36Hydroureter (HP:0000072)2.96134724
37Gastrointestinal dysmotility (HP:0002579)2.95553690
38Aplasia/Hypoplasia of the hallux (HP:0008362)2.95504881
39Osteolytic defects of the phalanges of the hand (HP:0009771)2.95324932
40Osteolytic defects of the hand bones (HP:0009699)2.95324932
41Scapular winging (HP:0003691)2.92121181
42Onycholysis (HP:0001806)2.90363531
43Abnormal foot bone ossification (HP:0010675)2.87124706
44Hematochezia (HP:0002573)2.86317842
45Atrophic scars (HP:0001075)2.84023852
46Tarsal synostosis (HP:0008368)2.81734229
47Furrowed tongue (HP:0000221)2.81203307
48Nephronophthisis (HP:0000090)2.79145043
49Abnormality of midbrain morphology (HP:0002418)2.74789314
50Molar tooth sign on MRI (HP:0002419)2.74789314
51Aortic regurgitation (HP:0001659)2.68985812
52Occipital encephalocele (HP:0002085)2.68857464
53Cystic liver disease (HP:0006706)2.68491327
54Increased density of long bones (HP:0006392)2.68054918
55Arterial tortuosity (HP:0005116)2.65222820
56Synostosis involving bones of the feet (HP:0009140)2.57949518
57Synostosis involving bones of the lower limbs (HP:0009138)2.57949518
58Decreased circulating renin level (HP:0003351)2.55282380
59Long toe (HP:0010511)2.54824440
60Abnormality of the renal medulla (HP:0100957)2.53641200
61Abnormality of DNA repair (HP:0003254)2.50284560
62Stridor (HP:0010307)2.50060536
63Milia (HP:0001056)2.49923547
64Ectropion (HP:0000656)2.49627904
65Bicuspid aortic valve (HP:0001647)2.49451436
66Hypoplastic labia majora (HP:0000059)2.47011750
67Hypoplasia of the iris (HP:0007676)2.45815463
68Decreased lacrimation (HP:0000633)2.45293998
69Vascular tortuosity (HP:0004948)2.44566731
70Bronchitis (HP:0012387)2.43339475
71Malnutrition (HP:0004395)2.41542440
72Striae distensae (HP:0001065)2.38288594
73Chronic hepatic failure (HP:0100626)2.37471984
74Abnormality of the renal cortex (HP:0011035)2.35058681
75Radial bowing (HP:0002986)2.34796231
76Dilatation of the ascending aorta (HP:0005111)2.34560773
77Hypotrichosis (HP:0001006)2.33830045
78Lip pit (HP:0100267)2.32979173
79Chronic sinusitis (HP:0011109)2.32492403
80Ureteral stenosis (HP:0000071)2.32249839
81Aplasia of the musculature (HP:0100854)2.31951594
82Rectal prolapse (HP:0002035)2.31853225
83Abnormality of the nasal mucosa (HP:0000433)2.31607479
84Abnormal hemoglobin (HP:0011902)2.31555466
85Aplasia involving bones of the upper limbs (HP:0009823)2.30510535
86Aplasia of the phalanges of the hand (HP:0009802)2.30510535
87Aplasia involving bones of the extremities (HP:0009825)2.30510535
88Anhidrosis (HP:0000970)2.30015699
89Hyporeflexia of lower limbs (HP:0002600)2.28772236
90Infertility (HP:0000789)2.28359756
91Abnormality of cochlea (HP:0000375)2.28014766
92Congenital hepatic fibrosis (HP:0002612)2.26662576
93Neoplasm of the heart (HP:0100544)2.25256321
94Camptodactyly of toe (HP:0001836)2.25226328
95Broad distal phalanx of finger (HP:0009836)2.24708732
96Alopecia of scalp (HP:0002293)2.24501413
97Aplasia/Hypoplasia of the scapulae (HP:0006713)2.23967137
98Hypoplastic scapulae (HP:0000882)2.23967137
99Plantar hyperkeratosis (HP:0007556)2.23427126
100Woolly hair (HP:0002224)2.21534550
101Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.21027288
102Medial flaring of the eyebrow (HP:0010747)2.18565023
103Mesomelia (HP:0003027)2.17202438
104Ureteral obstruction (HP:0006000)2.16154668
105Labial hypoplasia (HP:0000066)2.16145475
106Abnormality of the labia majora (HP:0012881)2.15758458
107Urethral obstruction (HP:0000796)2.15727385
108Abnormality of the distal phalanges of the toes (HP:0010182)2.14832945
109Hypoplastic left heart (HP:0004383)2.14473792
110Poikiloderma (HP:0001029)2.13756486
111Absent frontal sinuses (HP:0002688)2.13510666
112Tubulointerstitial fibrosis (HP:0005576)2.10522333
113Tubulointerstitial nephritis (HP:0001970)2.09563346
114Mitral valve prolapse (HP:0001634)2.09118019
115Persistence of primary teeth (HP:0006335)2.08729286
116Stomach cancer (HP:0012126)2.08440481
117Spastic diplegia (HP:0001264)2.03992918
118Femoral bowing (HP:0002980)2.03733162
119Muscle fiber splitting (HP:0003555)2.03201472
120Curly hair (HP:0002212)2.03187958
121Ureteral duplication (HP:0000073)2.02302036
122Selective tooth agenesis (HP:0001592)2.01039594
123Aplasia/Hypoplasia of the tongue (HP:0010295)2.00801262
124Short nail (HP:0001799)2.00209260
125Postaxial foot polydactyly (HP:0001830)1.99814173
126Systemic lupus erythematosus (HP:0002725)1.99080027
127Abnormality of nail color (HP:0100643)1.98519734
128Recurrent sinusitis (HP:0011108)1.98161728
129Wrist flexion contracture (HP:0001239)1.98128169
130Abnormality of the shoulder girdle musculature (HP:0001435)1.96266947
131Palpitations (HP:0001962)1.94043954
132Fragile nails (HP:0001808)1.93429281
133Stage 5 chronic kidney disease (HP:0003774)1.92919159
134Facial diplegia (HP:0001349)1.92652330
135Carpal synostosis (HP:0009702)1.92032879
136Polycythemia (HP:0001901)1.89403788
137Congenital, generalized hypertrichosis (HP:0004540)1.89146677
138Decreased central vision (HP:0007663)1.85961036
139Male pseudohermaphroditism (HP:0000037)1.85945054
140Renal salt wasting (HP:0000127)1.85026449
141Abnormality of oral frenula (HP:0000190)1.85022269
142Hypodontia (HP:0000668)1.84744169
143Severe short stature (HP:0003510)1.83560588
144Ventricular tachycardia (HP:0004756)1.83318874
145Reduced subcutaneous adipose tissue (HP:0003758)1.83101501
146Wormian bones (HP:0002645)1.82512235
147Hypoplastic female external genitalia (HP:0012815)1.82157830
148Abnormal pancreas size (HP:0012094)1.81652630
149Amelogenesis imperfecta (HP:0000705)1.81528956
150Humeroradial synostosis (HP:0003041)1.81177823
151Synostosis involving the elbow (HP:0003938)1.81177823
152Hyperkalemia (HP:0002153)1.81166201
153Increased mean platelet volume (HP:0011877)1.81117633
154Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.80890551
155Abnormality of the axillary hair (HP:0100134)1.80653601
156Abnormality of secondary sexual hair (HP:0009888)1.80653601
157Abnormality of the middle phalanges of the toes (HP:0010183)1.80497397
158Anencephaly (HP:0002323)1.80473986
159Tubulointerstitial abnormality (HP:0001969)1.79821613
160Absent toe (HP:0010760)1.79563454
161Abnormality of renin-angiotensin system (HP:0000847)1.78348207
162Recurrent otitis media (HP:0000403)1.77915863
163Erythema (HP:0010783)1.77043526
164Soft skin (HP:0000977)1.74893011
165Bicornuate uterus (HP:0000813)1.74656240
166Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.74426087
167Flat acetabular roof (HP:0003180)1.74414832
168Corneal erosion (HP:0200020)1.73632864
169Nonprogressive disorder (HP:0003680)1.73243783
170Hyperaldosteronism (HP:0000859)1.73210533
171Partial duplication of thumb phalanx (HP:0009944)1.73199000
172Synostosis of carpal bones (HP:0005048)1.72901067
173Disproportionate short-trunk short stature (HP:0003521)1.71440234
174Cardiovascular calcification (HP:0011915)1.70260773
175Abnormality of the phalanges of the 2nd finger (HP:0009541)1.69639336
176Fibular hypoplasia (HP:0003038)1.69523015
177Abnormal ossification of hand bones (HP:0005921)1.69368658
178Down-sloping shoulders (HP:0200021)1.69000830
179Aplasia/Hypoplasia of the spleen (HP:0010451)1.68495638
180Type 1 muscle fiber predominance (HP:0003803)1.67221514
181Interstitial pulmonary disease (HP:0006530)1.66555004
182Congenital primary aphakia (HP:0007707)1.66268149
183Pustule (HP:0200039)1.66210059
184Knee flexion contracture (HP:0006380)1.66203784
185Abnormality of the proximal phalanges of the hand (HP:0009834)1.65892480
186Sclerocornea (HP:0000647)1.64731657
187Short 4th metacarpal (HP:0010044)1.62651150
188Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.62651150
189Elbow flexion contracture (HP:0002987)1.61925544

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.23711972
2MYLK4.99604269
3MST43.89069322
4PBK3.52378543
5EPHA23.49863718
6TLK13.19333787
7MAP3K23.06036088
8FRK2.74193525
9DMPK2.63680980
10BMPR1B2.48504607
11MST1R2.46716939
12DAPK22.43766194
13LMTK22.34540492
14TGFBR22.32796921
15STK392.31015706
16AKT32.30049425
17MAP3K32.20768264
18NME12.11564856
19LATS11.97420158
20GRK11.93353112
21NUAK11.89165510
22EPHB21.87429119
23TRPM71.76137778
24ERN11.74857928
25RIPK11.73625369
26EPHA41.73508028
27PAK21.69378081
28PIK3CA1.65705726
29ACVR1B1.60927528
30LRRK21.56264085
31MAP3K121.47323465
32FER1.46225915
33PIK3CG1.38967239
34STK101.37972092
35SIK11.36722186
36INSRR1.36282851
37ERBB31.31840470
38MET1.31445599
39TESK11.24635938
40TRIB31.23477313
41MAP4K21.23272985
42EEF2K1.22393407
43ADRBK21.20912367
44BRSK21.20316451
45BCR1.17945163
46MAP3K41.15449560
47PTK21.14309379
48PAK41.12722082
49WNK41.12325223
50PTK61.11960660
51PDK21.10736602
52PKN21.10654813
53MAPKAPK31.08415663
54ADRBK11.07795006
55PAK31.06650363
56RPS6KB21.05167964
57OXSR11.02792993
58MAP2K71.01056830
59RPS6KA21.00146218
60STK30.98758405
61ILK0.97636944
62BCKDK0.96969709
63ROCK20.95289836
64MAPK150.93680574
65DDR20.91940870
66WNK30.90951058
67TYK20.90445272
68FGFR20.89329972
69PNCK0.89045934
70MAP3K60.88911106
71EIF2AK30.88417212
72PINK10.83799469
73ROCK10.82181487
74STK380.81815407
75MAP2K30.78074808
76FLT30.75782104
77NEK90.74321260
78EPHB10.71716975
79TAOK30.70773176
80MAP2K20.67100160
81SCYL20.65670431
82RPS6KC10.63482275
83RPS6KL10.63482275
84MAP2K10.62911640
85MAPK130.61842679
86PRKCE0.61684561
87PDGFRA0.61444308
88MAP3K70.59920003
89DAPK30.58661624
90PDGFRB0.57388555
91CASK0.55324980
92CAMK2G0.55324165
93RPS6KA60.54438415
94STK38L0.53952797
95CDK60.53430624
96LIMK10.52500077
97IGF1R0.50621142
98CAMKK20.50360850
99RPS6KA40.50177568
100WNK10.49111230
101GSK3A0.45122086
102WEE10.44851436
103TGFBR10.43984979
104MAP3K80.43822237
105CSF1R0.43106468
106CSK0.42349894
107PRKD10.41641285
108PRKAA20.41168854
109OBSCN0.41166456
110PAK10.41164116
111MAPKAPK20.40299379
112MAP2K40.37934677
113CDC42BPA0.37853398
114ERBB20.37822072
115DAPK10.37390842
116MKNK10.37225163
117RPS6KA50.37014670
118JAK30.35876024
119PRKCI0.34574045
120FGFR10.34251348
121PTK2B0.32814970
122SRC0.32191741
123EGFR0.32169989
124MAPKAPK50.30989623
125ZAP700.30727142
126PRKCQ0.30447631
127CAMK2A0.30395729
128NLK0.30324583
129MAP2K60.29802126
130STK240.29723487
131PRKCA0.29167160
132TIE10.29003866
133JAK10.28996920
134ERBB40.28410801
135FYN0.28071548
136INSR0.27641153
137PHKG20.27455902
138PHKG10.27455902
139PRKACA0.27408001
140CAMK1D0.26428168
141ZAK0.26136450
142NEK60.25647447
143MATK0.25171729
144ABL10.24780843
145JAK20.24535830
146PRKG10.24281308
147CHUK0.23990212
148AKT20.22409694
149TXK0.22230441
150PKN10.21640059
151PRKACB0.19293857
152SGK4940.19292891
153SGK2230.19292891
154PRKCG0.18505681
155GRK70.18274031

Predicted pathways (KEGG)

RankGene SetZ-score
1Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.51733055
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.36178210
3Chemical carcinogenesis_Homo sapiens_hsa052043.74094819
4Glutathione metabolism_Homo sapiens_hsa004802.84195513
5Linoleic acid metabolism_Homo sapiens_hsa005912.40017445
6Caffeine metabolism_Homo sapiens_hsa002322.37443319
7Bladder cancer_Homo sapiens_hsa052192.31421289
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.29430435
9Sulfur metabolism_Homo sapiens_hsa009202.29237871
10Adherens junction_Homo sapiens_hsa045202.08908871
11Pentose and glucuronate interconversions_Homo sapiens_hsa000401.93106563
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.92891261
13Hedgehog signaling pathway_Homo sapiens_hsa043401.92492811
14ECM-receptor interaction_Homo sapiens_hsa045121.89130755
15Focal adhesion_Homo sapiens_hsa045101.81082325
16Tight junction_Homo sapiens_hsa045301.75892576
17Nitrogen metabolism_Homo sapiens_hsa009101.65931217
18Leukocyte transendothelial migration_Homo sapiens_hsa046701.61361767
19Phenylalanine metabolism_Homo sapiens_hsa003601.57323383
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.55577315
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.52430503
22Arachidonic acid metabolism_Homo sapiens_hsa005901.49866972
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.48953297
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.45049240
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.42189756
26Proteoglycans in cancer_Homo sapiens_hsa052051.42045890
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.41174531
28Ether lipid metabolism_Homo sapiens_hsa005651.40584732
29Amoebiasis_Homo sapiens_hsa051461.36229782
30Phototransduction_Homo sapiens_hsa047441.35997618
31Hippo signaling pathway_Homo sapiens_hsa043901.33974439
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33495587
33Butanoate metabolism_Homo sapiens_hsa006501.28826495
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28419963
35Other glycan degradation_Homo sapiens_hsa005111.27859495
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.27537122
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24675722
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.24539652
39Prostate cancer_Homo sapiens_hsa052151.23495555
40Sphingolipid metabolism_Homo sapiens_hsa006001.23364275
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.23319662
42beta-Alanine metabolism_Homo sapiens_hsa004101.19740755
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19278021
44Tryptophan metabolism_Homo sapiens_hsa003801.17014814
45Small cell lung cancer_Homo sapiens_hsa052221.16644439
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.15779258
47Huntingtons disease_Homo sapiens_hsa050161.14932745
48Tyrosine metabolism_Homo sapiens_hsa003501.13828130
49Retinol metabolism_Homo sapiens_hsa008301.12209960
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10629043
51ABC transporters_Homo sapiens_hsa020101.10173361
52N-Glycan biosynthesis_Homo sapiens_hsa005101.09517031
53Histidine metabolism_Homo sapiens_hsa003401.09077093
54TGF-beta signaling pathway_Homo sapiens_hsa043501.08966781
55Peroxisome_Homo sapiens_hsa041461.08516560
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08140821
57Protein export_Homo sapiens_hsa030601.04673437
58Dilated cardiomyopathy_Homo sapiens_hsa054141.04608151
59Oxidative phosphorylation_Homo sapiens_hsa001901.04144720
60Toxoplasmosis_Homo sapiens_hsa051451.02333181
61Vibrio cholerae infection_Homo sapiens_hsa051101.01542825
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.98139241
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94335816
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94285156
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93000167
66Platelet activation_Homo sapiens_hsa046110.92150333
67Chronic myeloid leukemia_Homo sapiens_hsa052200.91908550
68Vitamin digestion and absorption_Homo sapiens_hsa049770.91193436
69Thyroid cancer_Homo sapiens_hsa052160.91053094
70Endometrial cancer_Homo sapiens_hsa052130.89572735
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89214869
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88931953
73Nucleotide excision repair_Homo sapiens_hsa034200.86622710
74Taste transduction_Homo sapiens_hsa047420.82592488
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81205377
76Pancreatic cancer_Homo sapiens_hsa052120.75649070
77Insulin resistance_Homo sapiens_hsa049310.74597773
78Gastric acid secretion_Homo sapiens_hsa049710.73989465
79Salmonella infection_Homo sapiens_hsa051320.70712108
80Circadian rhythm_Homo sapiens_hsa047100.68314802
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67693743
82Regulation of autophagy_Homo sapiens_hsa041400.67237037
83Pertussis_Homo sapiens_hsa051330.65244119
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65215226
85Lysosome_Homo sapiens_hsa041420.65200105
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63829053
87Thyroid hormone synthesis_Homo sapiens_hsa049180.63558317
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63307279
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62360648
90Fatty acid degradation_Homo sapiens_hsa000710.61374898
91Pathways in cancer_Homo sapiens_hsa052000.61303591
92Starch and sucrose metabolism_Homo sapiens_hsa005000.58502444
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58251009
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58196501
95Basal cell carcinoma_Homo sapiens_hsa052170.58166047
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57173994
97Metabolic pathways_Homo sapiens_hsa011000.56652591
98Prion diseases_Homo sapiens_hsa050200.56315477
99Protein digestion and absorption_Homo sapiens_hsa049740.54971067
100Ovarian steroidogenesis_Homo sapiens_hsa049130.54340476
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52777470
102PPAR signaling pathway_Homo sapiens_hsa033200.51879305
103Shigellosis_Homo sapiens_hsa051310.51506650
104Melanoma_Homo sapiens_hsa052180.50876342
105Estrogen signaling pathway_Homo sapiens_hsa049150.49995497
106TNF signaling pathway_Homo sapiens_hsa046680.49910544
107Rap1 signaling pathway_Homo sapiens_hsa040150.49674431
108Selenocompound metabolism_Homo sapiens_hsa004500.49421843
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.48346293
110Viral myocarditis_Homo sapiens_hsa054160.48183810
111Salivary secretion_Homo sapiens_hsa049700.47743585
112Non-small cell lung cancer_Homo sapiens_hsa052230.47319324
113Glioma_Homo sapiens_hsa052140.46602250
114Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46231957
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46202660
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45719028
117p53 signaling pathway_Homo sapiens_hsa041150.45438594
118Hepatitis C_Homo sapiens_hsa051600.45355899
119Renal cell carcinoma_Homo sapiens_hsa052110.44968709
120Melanogenesis_Homo sapiens_hsa049160.42620696
121Olfactory transduction_Homo sapiens_hsa047400.41958035
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41116929
123Renin-angiotensin system_Homo sapiens_hsa046140.39929742
124Leishmaniasis_Homo sapiens_hsa051400.38687179
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37807729
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.37539390
127Phagosome_Homo sapiens_hsa041450.36980684
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36958391
129Type I diabetes mellitus_Homo sapiens_hsa049400.36893964
130Graft-versus-host disease_Homo sapiens_hsa053320.35696352
131Parkinsons disease_Homo sapiens_hsa050120.34946827
132Colorectal cancer_Homo sapiens_hsa052100.34441249
133Glycerolipid metabolism_Homo sapiens_hsa005610.34351279
134FoxO signaling pathway_Homo sapiens_hsa040680.33864667
135Insulin signaling pathway_Homo sapiens_hsa049100.33163878
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33140478
137Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32880812
138Calcium signaling pathway_Homo sapiens_hsa040200.32532847
139Osteoclast differentiation_Homo sapiens_hsa043800.32454413
140Collecting duct acid secretion_Homo sapiens_hsa049660.32218819
141Oxytocin signaling pathway_Homo sapiens_hsa049210.31836151
142Nicotine addiction_Homo sapiens_hsa050330.31828593
143Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31819848
144Mineral absorption_Homo sapiens_hsa049780.31748311
145MicroRNAs in cancer_Homo sapiens_hsa052060.31716053
146Prolactin signaling pathway_Homo sapiens_hsa049170.31466564
147Endocytosis_Homo sapiens_hsa041440.31028322
148Acute myeloid leukemia_Homo sapiens_hsa052210.30428486
149Insulin secretion_Homo sapiens_hsa049110.30158409
150Gap junction_Homo sapiens_hsa045400.29852447
151Allograft rejection_Homo sapiens_hsa053300.29615375
152Homologous recombination_Homo sapiens_hsa034400.29163160
153Autoimmune thyroid disease_Homo sapiens_hsa053200.29058836
154Alzheimers disease_Homo sapiens_hsa050100.28738001
155Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28289684
156Pancreatic secretion_Homo sapiens_hsa049720.28036509
157Axon guidance_Homo sapiens_hsa043600.27729579
158RNA polymerase_Homo sapiens_hsa030200.26764329
159Steroid biosynthesis_Homo sapiens_hsa001000.24585764
160Fat digestion and absorption_Homo sapiens_hsa049750.21747621
161Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21443213
162Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18194158
163Serotonergic synapse_Homo sapiens_hsa047260.17320137
164Wnt signaling pathway_Homo sapiens_hsa043100.17036292

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