UPF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.76037284
2nuclear pore organization (GO:0006999)4.36835039
3heterochromatin organization (GO:0070828)4.12005525
4pre-miRNA processing (GO:0031054)4.01313546
5regulation of translational fidelity (GO:0006450)3.97345563
6protein localization to endosome (GO:0036010)3.96255522
7RNA stabilization (GO:0043489)3.67897550
8mRNA stabilization (GO:0048255)3.67897550
9protein localization to kinetochore (GO:0034501)3.57154950
10negative regulation of histone methylation (GO:0031061)3.54127756
11folic acid-containing compound biosynthetic process (GO:0009396)3.53245390
12positive regulation of histone deacetylation (GO:0031065)3.52741318
13pore complex assembly (GO:0046931)3.50245039
14COPI coating of Golgi vesicle (GO:0048205)3.45459048
15Golgi transport vesicle coating (GO:0048200)3.45459048
16regulation of gamma-delta T cell differentiation (GO:0045586)3.40031075
17mannose metabolic process (GO:0006013)3.30469396
18activation of Rac GTPase activity (GO:0032863)3.29816880
19epithelial cell differentiation involved in prostate gland development (GO:0060742)3.28345148
20regulation of early endosome to late endosome transport (GO:2000641)3.27380748
213-UTR-mediated mRNA stabilization (GO:0070935)3.26840273
22cytoskeletal anchoring at plasma membrane (GO:0007016)3.26529815
23regulation of histone H3-K9 methylation (GO:0051570)3.26211365
24chromatin assembly (GO:0031497)3.25233700
25positive regulation of Cdc42 GTPase activity (GO:0043089)3.23803931
26DNA unwinding involved in DNA replication (GO:0006268)3.18849693
27mitotic nuclear envelope disassembly (GO:0007077)3.18465355
28regulation of posttranscriptional gene silencing (GO:0060147)3.16257200
29regulation of gene silencing by miRNA (GO:0060964)3.16257200
30regulation of gene silencing by RNA (GO:0060966)3.16257200
31protein localization to chromosome, centromeric region (GO:0071459)3.12588674
32sister chromatid segregation (GO:0000819)3.06539595
33regulation of hippo signaling (GO:0035330)3.05511183
34negative regulation of erythrocyte differentiation (GO:0045647)3.01891579
35maternal placenta development (GO:0001893)2.99998494
36DNA duplex unwinding (GO:0032508)2.99981059
37membrane disassembly (GO:0030397)2.98046466
38nuclear envelope disassembly (GO:0051081)2.98046466
39mitotic sister chromatid segregation (GO:0000070)2.96979677
40DNA geometric change (GO:0032392)2.96292545
41regulation of gamma-delta T cell activation (GO:0046643)2.95103969
42intracellular estrogen receptor signaling pathway (GO:0030520)2.93240590
43positive regulation by symbiont of host defense response (GO:0052509)2.91085495
44modulation by symbiont of host defense response (GO:0052031)2.91085495
45modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.91085495
46modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.91085495
47positive regulation by organism of defense response of other organism involved in symbiotic interact2.91085495
48modulation by symbiont of host immune response (GO:0052553)2.91085495
49trophectodermal cell differentiation (GO:0001829)2.86700467
50glucocorticoid receptor signaling pathway (GO:0042921)2.85998506
51modulation by symbiont of host cellular process (GO:0044068)2.84968921
52stress fiber assembly (GO:0043149)2.82642231
53regulation of histone H3-K27 methylation (GO:0061085)2.82209194
54IMP biosynthetic process (GO:0006188)2.82120884
55retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.81129995
56regulation of cholesterol homeostasis (GO:2000188)2.80637383
57regulation of glucose import in response to insulin stimulus (GO:2001273)2.80476852
58response to muramyl dipeptide (GO:0032495)2.79175201
59NLS-bearing protein import into nucleus (GO:0006607)2.76256300
60mitotic chromosome condensation (GO:0007076)2.73736630
61protein-DNA complex disassembly (GO:0032986)2.72824003
62nucleosome disassembly (GO:0006337)2.72824003
63apoptotic process involved in morphogenesis (GO:0060561)2.72670631
64antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.72305879
65antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.72305879
66regulation of chromatin binding (GO:0035561)2.71513731
67spliceosomal tri-snRNP complex assembly (GO:0000244)2.70379078
68positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.70038273
69negative regulation of cell killing (GO:0031342)2.69793956
70negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.69793956
71positive regulation of protein deacetylation (GO:0090312)2.69242112
72regulation of mRNA stability (GO:0043488)2.68681730
73histone H2A monoubiquitination (GO:0035518)2.68274637
74peptidyl-lysine dimethylation (GO:0018027)2.67196588
75positive regulation of gamma-delta T cell activation (GO:0046645)2.65826247
76regulation of interleukin-12 biosynthetic process (GO:0045075)2.65793912
77negative regulation of viral release from host cell (GO:1902187)2.65683250
78regulation of nucleobase-containing compound transport (GO:0032239)2.64143401
79response to peptidoglycan (GO:0032494)2.63833729
80barbed-end actin filament capping (GO:0051016)2.63688273
81negative regulation of fatty acid transport (GO:2000192)2.63390545
82modulation by virus of host process (GO:0019054)2.63278219
83negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.62341591
84positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.62199023
85histone H4-K12 acetylation (GO:0043983)2.62192128
86negative regulation of histone modification (GO:0031057)2.62027943
87thymic T cell selection (GO:0045061)2.60147072
88gene silencing (GO:0016458)2.60028705
89regulation of ARF protein signal transduction (GO:0032012)2.59869283
90positive regulation of gene expression, epigenetic (GO:0045815)2.59439601
91chromatin silencing (GO:0006342)2.58979798
92positive thymic T cell selection (GO:0045059)2.58309672
93regulation of mammary gland epithelial cell proliferation (GO:0033599)2.57577275
94embryonic process involved in female pregnancy (GO:0060136)2.57147893
95regulation of extracellular matrix disassembly (GO:0010715)2.57120483
96planar cell polarity pathway involved in neural tube closure (GO:0090179)2.56738778
97regulation of RNA stability (GO:0043487)2.55875948
98pinocytosis (GO:0006907)2.55867294
99negative regulation of myotube differentiation (GO:0010832)2.53254407
100pentose-phosphate shunt (GO:0006098)2.52841531
101negative regulation of cell size (GO:0045792)2.52661463
102detection of other organism (GO:0098543)2.51105420
103regulation of type I interferon-mediated signaling pathway (GO:0060338)2.50860825
104gene silencing by RNA (GO:0031047)2.50793546
105cytoplasmic mRNA processing body assembly (GO:0033962)2.50622374
106negative regulation of toll-like receptor signaling pathway (GO:0034122)2.50511040
107detection of bacterium (GO:0016045)2.49883191
108antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.49289037
109adherens junction assembly (GO:0034333)2.49021186
110corticosteroid receptor signaling pathway (GO:0031958)2.48976916
111negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.47633220
112positive regulation of SMAD protein import into nucleus (GO:0060391)2.46942745
113positive regulation of blood vessel endothelial cell migration (GO:0043536)2.45399500
114hemidesmosome assembly (GO:0031581)2.45257138
115proline biosynthetic process (GO:0006561)2.44185033
116positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.43884262
117nuclear envelope organization (GO:0006998)2.43731682
118germinal center formation (GO:0002467)2.43230346
119mitotic sister chromatid cohesion (GO:0007064)2.43129670
120hypotonic response (GO:0006971)2.42536997
121cell-substrate adherens junction assembly (GO:0007045)2.42405745
122focal adhesion assembly (GO:0048041)2.42405745
123nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.42190098
124regulation of RNA export from nucleus (GO:0046831)2.41878892
125positive regulation of receptor recycling (GO:0001921)2.41441451
126response to UV-C (GO:0010225)2.40139206
127negative regulation of chromatin modification (GO:1903309)2.40064213
128semaphorin-plexin signaling pathway (GO:0071526)2.39740238
129positive regulation of chromosome segregation (GO:0051984)2.39554880
130antigen processing and presentation of endogenous antigen (GO:0019883)2.39149620
131activation of MAPKKK activity (GO:0000185)2.38465820
132regulation of NFAT protein import into nucleus (GO:0051532)2.38372392
133epithelial cell-cell adhesion (GO:0090136)2.38248164
134mitotic G1 DNA damage checkpoint (GO:0031571)2.37441960
135basement membrane organization (GO:0071711)2.37113188
136positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.36667732
137signal complex assembly (GO:0007172)2.36360227
138histone H3-K36 demethylation (GO:0070544)2.36038958
139histone lysine demethylation (GO:0070076)2.35999684
140positive regulation of protein import into nucleus, translocation (GO:0033160)2.35496558
141NIK/NF-kappaB signaling (GO:0038061)2.35038287
142regulation of gene silencing (GO:0060968)2.34528452
143IMP metabolic process (GO:0046040)2.34196134
144embryonic placenta development (GO:0001892)2.34081226
145regulation of protein polyubiquitination (GO:1902914)2.33902105
146tetrahydrofolate metabolic process (GO:0046653)2.33888017
147cellular response to epidermal growth factor stimulus (GO:0071364)2.33865534
148glycine metabolic process (GO:0006544)2.33561099
149positive regulation of RNA splicing (GO:0033120)2.33238328
150cell-substrate junction assembly (GO:0007044)2.33211664
151modulation by virus of host morphology or physiology (GO:0019048)2.33150558
152cellular protein complex localization (GO:0034629)2.32238666
153cellular hyperosmotic response (GO:0071474)2.31773265
154positive regulation of protein dephosphorylation (GO:0035307)2.31191239
155negative regulation of gene expression, epigenetic (GO:0045814)2.31135370
156paraxial mesoderm development (GO:0048339)2.31017437
157regulation of fatty acid beta-oxidation (GO:0031998)2.30998391
158regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.30939328
159DNA conformation change (GO:0071103)2.30811848
160negative regulation of DNA repair (GO:0045738)2.30553534
161response to laminar fluid shear stress (GO:0034616)2.30320560
162cellular response to virus (GO:0098586)2.30319628
163negative regulation of mRNA metabolic process (GO:1903312)2.30033049
164histone demethylation (GO:0016577)2.29359041
165macrophage activation involved in immune response (GO:0002281)2.28836275
166activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.25595436
167regulation of leukocyte degranulation (GO:0043300)2.25309686
168protein retention in ER lumen (GO:0006621)2.24443285
169negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.24306649
170cortical actin cytoskeleton organization (GO:0030866)2.23413242
171regulation of defense response to virus by virus (GO:0050690)2.22964532
172maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.22054764

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.67234251
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.02447836
3MYC_22102868_ChIP-Seq_BL_Human3.62166991
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.46164814
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.23500634
6VDR_21846776_ChIP-Seq_THP-1_Human2.41986675
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31835416
8TCF7_22412390_ChIP-Seq_EML_Mouse2.21828554
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.12774078
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04873311
11KDM2B_26808549_Chip-Seq_DND41_Human2.01142656
12KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.99549780
13TP63_17297297_ChIP-ChIP_HaCaT_Human1.98090977
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.97521503
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.96786081
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.96779931
17E2F4_17652178_ChIP-ChIP_JURKAT_Human1.92412242
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89924753
19ELK3_25401928_ChIP-Seq_HUVEC_Human1.81923619
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.81822636
21ZNF263_19887448_ChIP-Seq_K562_Human1.78340686
22PPARA_22158963_ChIP-Seq_LIVER_Mouse1.77734990
23SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.76090738
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73583418
25UTX_26944678_Chip-Seq_JUKART_Human1.71426440
26MAF_26560356_Chip-Seq_TH1_Human1.69240328
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.68173307
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.66036738
29STAT3_1855785_ChIP-Seq_MESCs_Mouse1.65790914
30RXR_22158963_ChIP-Seq_LIVER_Mouse1.55902378
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.54592902
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51272598
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41929408
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.40418268
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39177074
36EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39176429
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36910514
38* NCOR1_26117541_ChIP-Seq_K562_Human1.36712970
39UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36208986
40* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35823878
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35218766
42AR_21909140_ChIP-Seq_LNCAP_Human1.34610179
43RACK7_27058665_Chip-Seq_MCF-7_Human1.34541122
44* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.34039082
45SMC4_20622854_ChIP-Seq_HELA_Human1.33410577
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.32831351
47MYB_26560356_Chip-Seq_TH1_Human1.32112081
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31488436
49CIITA_25753668_ChIP-Seq_RAJI_Human1.31239562
50* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30949687
51ATF3_27146783_Chip-Seq_COLON_Human1.30498521
52SA1_27219007_Chip-Seq_ERYTHROID_Human1.30449821
53CLOCK_20551151_ChIP-Seq_293T_Human1.30310298
54SCL_19346495_ChIP-Seq_HPC-7_Human1.30197477
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29707071
56LXR_22292898_ChIP-Seq_THP-1_Human1.28116518
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27122411
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26331724
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26136657
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.24066008
61VDR_24763502_ChIP-Seq_THP-1_Human1.23317635
62SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22481389
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22457896
64TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22170337
65* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21798421
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21728422
67RUNX1_27514584_Chip-Seq_MCF-7_Human1.21705087
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.20899477
69* LXR_22158963_ChIP-Seq_LIVER_Mouse1.20337045
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19718152
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19452390
72PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18741695
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18493497
74HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18466094
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18132533
76RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17799780
77RUNX1_22412390_ChIP-Seq_EML_Mouse1.17618083
78* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17106159
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16428463
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16279714
81KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.16231853
82KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.16231853
83KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.16231853
84MAF_26560356_Chip-Seq_TH2_Human1.15919382
85DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14917890
86GATA1_19941827_ChIP-Seq_MEL_Mouse1.13399415
87ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13163991
88* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12593117
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.12270971
90EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11927883
91KDM5A_27292631_Chip-Seq_BREAST_Human1.11925862
92* MYB_26560356_Chip-Seq_TH2_Human1.11283003
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10118435
94* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09377713
95MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08892252
96SPI1_23127762_ChIP-Seq_K562_Human1.08500673
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06261475
98GATA6_25053715_ChIP-Seq_YYC3_Human1.05592750
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03701587
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02221309
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01941134
102GATA1_19941826_ChIP-Seq_K562_Human1.01833579
103TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01461422
104UBF1/2_26484160_Chip-Seq_HMECs_Human1.01258687
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01204086
106CREB1_26743006_Chip-Seq_LNCaP_Human1.00673950
107FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00205668
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99835967
109ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99346893
110RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99098164
111P68_20966046_ChIP-Seq_HELA_Human0.99007625
112ELF1_20517297_ChIP-Seq_JURKAT_Human0.97995757
113SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97812555
114CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97358617
115NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97314364
116CHD1_26751641_Chip-Seq_LNCaP_Human0.96615056
117ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96059442
118ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95323581
119BCOR_27268052_Chip-Seq_Bcells_Human0.95240163
120TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95135608
121KDM2B_26808549_Chip-Seq_K562_Human0.94784286
122* TP53_22127205_ChIP-Seq_IMR90_Human0.94306419
123DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94273998
124NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94218425
125CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94013899
126NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93978832
127MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.93877344
128* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93795926
129STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93287807
130PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93287239
131FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92766631
132NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92515675
133MYC_19030024_ChIP-ChIP_MESCs_Mouse0.92366305
134CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91446408
135POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.90186967
136GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89694519
137* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.89617126
138DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89446279
139CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88514580
140SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.87714766

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.12895722
2MP0010352_gastrointestinal_tract_polyps3.18425785
3MP0005451_abnormal_body_composition3.15517206
4MP0005076_abnormal_cell_differentiation2.67081278
5MP0003300_gastrointestinal_ulcer2.55430118
6MP0008260_abnormal_autophagy2.40486282
7MP0010307_abnormal_tumor_latency2.34320202
8MP0003111_abnormal_nucleus_morphology2.23958537
9MP0005058_abnormal_lysosome_morphology2.15501170
10MP0003566_abnormal_cell_adhesion2.07482774
11MP0009278_abnormal_bone_marrow1.98332817
12MP0005409_darkened_coat_color1.95413916
13MP0004858_abnormal_nervous_system1.94456586
14MP0002877_abnormal_melanocyte_morpholog1.93523411
15MP0003077_abnormal_cell_cycle1.82077269
16MP0002396_abnormal_hematopoietic_system1.81471753
17MP0010094_abnormal_chromosome_stability1.80955703
18MP0005360_urolithiasis1.74435594
19MP0010234_abnormal_vibrissa_follicle1.74397709
20MP0001730_embryonic_growth_arrest1.69688089
21MP0000678_abnormal_parathyroid_gland1.69062944
22MP0008438_abnormal_cutaneous_collagen1.69020371
23MP0008057_abnormal_DNA_replication1.68829985
24MP0004957_abnormal_blastocyst_morpholog1.68777134
25MP0004808_abnormal_hematopoietic_stem1.68720809
26MP0003303_peritoneal_inflammation1.68539601
27MP0002139_abnormal_hepatobiliary_system1.66093159
28MP0000350_abnormal_cell_proliferation1.61921022
29MP0003763_abnormal_thymus_physiology1.58695037
30MP0003252_abnormal_bile_duct1.57985004
31MP0004197_abnormal_fetal_growth/weight/1.57752804
32MP0009840_abnormal_foam_cell1.57120544
33MP0002086_abnormal_extraembryonic_tissu1.55054527
34MP0003693_abnormal_embryo_hatching1.53942837
35MP0001545_abnormal_hematopoietic_system1.52049976
36MP0005397_hematopoietic_system_phenotyp1.52049976
37MP0001348_abnormal_lacrimal_gland1.49622337
38MP0003984_embryonic_growth_retardation1.48721340
39MP0004264_abnormal_extraembryonic_tissu1.48251624
40MP0002088_abnormal_embryonic_growth/wei1.48050779
41MP0003172_abnormal_lysosome_physiology1.47917493
42MP0001849_ear_inflammation1.47881762
43* MP0001672_abnormal_embryogenesis/_devel1.47779220
44* MP0005380_embryogenesis_phenotype1.47779220
45MP0005023_abnormal_wound_healing1.43743978
46MP0004233_abnormal_muscle_weight1.40252745
47MP0001915_intracranial_hemorrhage1.35258424
48MP0002166_altered_tumor_susceptibility1.29048514
49MP0009053_abnormal_anal_canal1.26924705
50MP0003191_abnormal_cellular_cholesterol1.25983369
51MP0000733_abnormal_muscle_development1.25935198
52MP0004185_abnormal_adipocyte_glucose1.25837817
53MP0008007_abnormal_cellular_replicative1.23968987
54MP0001697_abnormal_embryo_size1.23813628
55MP0003329_amyloid_beta_deposits1.21337885
56MP0003453_abnormal_keratinocyte_physiol1.21294458
57MP0002084_abnormal_developmental_patter1.20955460
58MP0005085_abnormal_gallbladder_physiolo1.20411903
59MP0005623_abnormal_meninges_morphology1.17321054
60MP0002419_abnormal_innate_immunity1.16299564
61MP0000685_abnormal_immune_system1.15888287
62MP0002085_abnormal_embryonic_tissue1.15222755
63MP0002398_abnormal_bone_marrow1.14953434
64MP0002019_abnormal_tumor_incidence1.14445830
65MP0002089_abnormal_postnatal_growth/wei1.14254236
66MP0004381_abnormal_hair_follicle1.13976183
67MP0005375_adipose_tissue_phenotype1.13730409
68MP0000609_abnormal_liver_physiology1.13715945
69MP0003806_abnormal_nucleotide_metabolis1.13189995
70MP0000537_abnormal_urethra_morphology1.13015373
71MP0002998_abnormal_bone_remodeling1.12982669
72MP0005025_abnormal_response_to1.12764800
73MP0000703_abnormal_thymus_morphology1.12674790
74* MP0002080_prenatal_lethality1.12040028
75MP0000490_abnormal_crypts_of1.12024695
76MP0004510_myositis1.11862602
77MP0010155_abnormal_intestine_physiology1.10752869
78MP0004947_skin_inflammation1.10367663
79MP0001958_emphysema1.08687885
80MP0005365_abnormal_bile_salt1.08198008
81MP0003436_decreased_susceptibility_to1.08116641
82MP0002722_abnormal_immune_system1.06546772
83MP0005000_abnormal_immune_tolerance1.05141860
84MP0000689_abnormal_spleen_morphology1.05114548
85MP0001533_abnormal_skeleton_physiology1.04936026
86MP0003828_pulmonary_edema1.03892986
87MP0001800_abnormal_humoral_immune1.02165782
88MP0008961_abnormal_basal_metabolism1.01471543
89MP0010630_abnormal_cardiac_muscle1.01410495
90MP0002249_abnormal_larynx_morphology1.01202705
91MP0003567_abnormal_fetal_cardiomyocyte1.00051176
92MP0001835_abnormal_antigen_presentation0.99284525
93MP0009672_abnormal_birth_weight0.99027980
94MP0000598_abnormal_liver_morphology0.97568451
95MP0000003_abnormal_adipose_tissue0.96157162
96MP0002006_tumorigenesis0.95926274
97MP0005666_abnormal_adipose_tissue0.95598650
98MP0001216_abnormal_epidermal_layer0.95494255
99MP0005257_abnormal_intraocular_pressure0.94532386
100MP0000858_altered_metastatic_potential0.93251095
101MP0002925_abnormal_cardiovascular_devel0.92985548
102MP0002653_abnormal_ependyma_morphology0.92240698
103MP0003115_abnormal_respiratory_system0.91299556
104MP0003091_abnormal_cell_migration0.90683673
105MP0005464_abnormal_platelet_physiology0.90473887
106MP0002420_abnormal_adaptive_immunity0.89203013
107MP0001819_abnormal_immune_cell0.88850471
108MP0003075_altered_response_to0.87784783
109MP0002405_respiratory_system_inflammati0.87652538
110MP0009333_abnormal_splenocyte_physiolog0.87389507
111MP0002009_preneoplasia0.87372455
112MP0000477_abnormal_intestine_morphology0.87287292
113MP0005501_abnormal_skin_physiology0.86332049
114MP0004272_abnormal_basement_membrane0.85947247
115* MP0000313_abnormal_cell_death0.85289129
116MP0010329_abnormal_lipoprotein_level0.85243663
117MP0002452_abnormal_antigen_presenting0.85176361
118MP0000747_muscle_weakness0.83455352
119MP0002060_abnormal_skin_morphology0.83259360
120MP0002723_abnormal_immune_serum0.82139064
121MP0001851_eye_inflammation0.82045329
122MP0003279_aneurysm0.81979949
123MP0002429_abnormal_blood_cell0.80832549
124MP0001243_abnormal_dermal_layer0.80278214
125MP0001873_stomach_inflammation0.79116457
126MP0000716_abnormal_immune_system0.78284943
127MP0009703_decreased_birth_body0.77573252
128MP0003045_fibrosis0.77237185
129MP0005310_abnormal_salivary_gland0.77198673
130MP0003448_altered_tumor_morphology0.76332981
131MP0000767_abnormal_smooth_muscle0.75911682
132MP0000266_abnormal_heart_morphology0.74937893
133MP0003866_abnormal_defecation0.74302556
134MP0005387_immune_system_phenotype0.73896648
135MP0001790_abnormal_immune_system0.73896648
136MP0002796_impaired_skin_barrier0.72350233
137MP0008770_decreased_survivor_rate0.71872507
138MP0000604_amyloidosis0.71722320
139MP0002098_abnormal_vibrissa_morphology0.71640969
140MP0009931_abnormal_skin_appearance0.70998496
141MP0005083_abnormal_biliary_tract0.69949485
142MP0005621_abnormal_cell_physiology0.69378121

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.05216642
2Broad face (HP:0000283)2.95025870
3Eczematoid dermatitis (HP:0000976)2.93780604
4Obstructive sleep apnea (HP:0002870)2.87002102
5Cerebral aneurysm (HP:0004944)2.84323663
6Abnormality of the fingertips (HP:0001211)2.82051807
7Pseudobulbar signs (HP:0002200)2.70720461
8Ependymoma (HP:0002888)2.62340354
9Flat acetabular roof (HP:0003180)2.56769341
10Abnormality of the lower motor neuron (HP:0002366)2.47595063
11Increased connective tissue (HP:0009025)2.47085362
12Myocardial infarction (HP:0001658)2.42172915
13Ulnar bowing (HP:0003031)2.38511026
14Premature rupture of membranes (HP:0001788)2.38167429
15Deep venous thrombosis (HP:0002625)2.37403251
16Upper limb amyotrophy (HP:0009129)2.24889247
17Distal upper limb amyotrophy (HP:0007149)2.24889247
18Renovascular hypertension (HP:0100817)2.24091510
19Distal lower limb muscle weakness (HP:0009053)2.21522901
20Hand muscle atrophy (HP:0009130)2.20683517
21Centrally nucleated skeletal muscle fibers (HP:0003687)2.20507588
22Vertebral compression fractures (HP:0002953)2.18660072
23Increased density of long bones (HP:0006392)2.16757306
24Abnormal platelet volume (HP:0011876)2.16745519
25Hemorrhage of the eye (HP:0011885)2.14778808
26Thin bony cortex (HP:0002753)2.13854760
27Ankyloglossia (HP:0010296)2.13244791
28Astrocytoma (HP:0009592)2.12974926
29Abnormality of the astrocytes (HP:0100707)2.12974926
30Heterotopia (HP:0002282)2.12636599
31Segmental peripheral demyelination/remyelination (HP:0003481)2.11721235
32Increased IgE level (HP:0003212)2.10644245
33Increased mean platelet volume (HP:0011877)2.08606951
34Basal cell carcinoma (HP:0002671)2.08502670
35Mitral valve prolapse (HP:0001634)2.08048487
36Reticulocytosis (HP:0001923)2.06451643
37Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05899992
38Short 4th metacarpal (HP:0010044)2.05899992
39Shallow orbits (HP:0000586)2.05150131
40Long palpebral fissure (HP:0000637)2.04880144
41Selective tooth agenesis (HP:0001592)2.03472432
42Protrusio acetabuli (HP:0003179)2.02427505
43High pitched voice (HP:0001620)2.01703116
44Abnormality of the distal phalanx of the thumb (HP:0009617)2.00905781
45Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.00580832
46Aneurysm (HP:0002617)1.99778897
47Increased variability in muscle fiber diameter (HP:0003557)1.99530465
48Deviation of the thumb (HP:0009603)1.98141201
49Increased nuchal translucency (HP:0010880)1.97386005
50Elfin facies (HP:0004428)1.96460317
51Dilatation of the ascending aorta (HP:0005111)1.96427577
52Urethral obstruction (HP:0000796)1.93793782
53Abnormality of oral frenula (HP:0000190)1.93691958
54Asymmetry of the thorax (HP:0001555)1.93359325
55Spastic diplegia (HP:0001264)1.92679207
56Fragile skin (HP:0001030)1.92373413
57Abnormality of monocarboxylic acid metabolism (HP:0010996)1.91068098
58Long eyelashes (HP:0000527)1.89668228
59Osteolytic defects of the phalanges of the hand (HP:0009771)1.89130339
60Osteolytic defects of the hand bones (HP:0009699)1.89130339
61Abnormality of the distal phalanges of the toes (HP:0010182)1.88689513
62Cerebral inclusion bodies (HP:0100314)1.87829195
63Abnormality of macrophages (HP:0004311)1.87581014
64Esophageal varix (HP:0002040)1.86288087
65Ankle contracture (HP:0006466)1.84590601
66Genu recurvatum (HP:0002816)1.83230748
67Abnormality of the 4th metacarpal (HP:0010012)1.83066738
68Interstitial pulmonary disease (HP:0006530)1.83015561
69Cervical subluxation (HP:0003308)1.82686665
70Polygenic inheritance (HP:0010982)1.82286862
71Dysmetric saccades (HP:0000641)1.82245475
72Cutaneous melanoma (HP:0012056)1.82072986
73Nasal polyposis (HP:0100582)1.81896664
74Gingivitis (HP:0000230)1.81779583
75Abnormality of skeletal muscle fiber size (HP:0012084)1.81572922
76Autoimmune thrombocytopenia (HP:0001973)1.80850463
77Recurrent abscess formation (HP:0002722)1.80308411
78Abnormality of the thoracic spine (HP:0100711)1.80182132
79Subacute progressive viral hepatitis (HP:0006572)1.79863925
80Renal duplication (HP:0000075)1.78714156
81Metaphyseal cupping (HP:0003021)1.78237324
82Mitral regurgitation (HP:0001653)1.78124528
83Short nail (HP:0001799)1.78116040
84Distal lower limb amyotrophy (HP:0008944)1.77420102
85Persistence of primary teeth (HP:0006335)1.76791569
86Macroorchidism (HP:0000053)1.76092913
87Lower limb amyotrophy (HP:0007210)1.75540509
88Colitis (HP:0002583)1.75308148
89Hyperparathyroidism (HP:0000843)1.75300114
90Proximal placement of thumb (HP:0009623)1.75068479
91Back pain (HP:0003418)1.74587886
92Abnormality of the peritoneum (HP:0002585)1.74388054
93Dislocated radial head (HP:0003083)1.73706391
94Rhabdomyosarcoma (HP:0002859)1.73498727
95Neoplasm of striated muscle (HP:0009728)1.73388403
96Advanced eruption of teeth (HP:0006288)1.72977027
97Cellulitis (HP:0100658)1.72117087
98Rectal prolapse (HP:0002035)1.71748014
99Polycythemia (HP:0001901)1.71330303
100Difficulty climbing stairs (HP:0003551)1.70498057
101Lymphangioma (HP:0100764)1.70312690
102Emphysema (HP:0002097)1.70312423
103Recurrent bacterial skin infections (HP:0005406)1.70199549
104Sandal gap (HP:0001852)1.69592933
105Blue sclerae (HP:0000592)1.69155366
106Bowel diverticulosis (HP:0005222)1.68269234
107Abnormality of the nasal mucosa (HP:0000433)1.68197768
108Verrucae (HP:0200043)1.67591572
109Papilloma (HP:0012740)1.67591572
110Broad palm (HP:0001169)1.66955390
111Gastrointestinal inflammation (HP:0004386)1.66628567
112Malignant gastrointestinal tract tumors (HP:0006749)1.66296068
113Gastrointestinal carcinoma (HP:0002672)1.66296068
114Aortic aneurysm (HP:0004942)1.65562317
115Slow saccadic eye movements (HP:0000514)1.64868510
116Enlarged penis (HP:0000040)1.64753087
117Atrophic scars (HP:0001075)1.64691615
118Gastrointestinal stroma tumor (HP:0100723)1.64569855
119Vertebral clefting (HP:0008428)1.64453964
120Abnormality of the Achilles tendon (HP:0005109)1.64408869
121Abnormality of pyrimidine metabolism (HP:0004353)1.64040433
122Missing ribs (HP:0000921)1.63922981
123Insomnia (HP:0100785)1.63779443
124Abnormality of the salivary glands (HP:0010286)1.63376109
125Cutis marmorata (HP:0000965)1.63078519
126Stridor (HP:0010307)1.63007051
127Hypercortisolism (HP:0001578)1.62920907
128Skin tags (HP:0010609)1.62427942
129Prominent nose (HP:0000448)1.61048058
130Recurrent viral infections (HP:0004429)1.60031814
131Mildly elevated creatine phosphokinase (HP:0008180)1.59761178
132Abnormal vertebral ossification (HP:0100569)1.59344540
133Biconcave vertebral bodies (HP:0004586)1.58724097
134Abnormal delayed hypersensitivity skin test (HP:0002963)1.58145627
135Skull defect (HP:0001362)1.58054038
136Arterial tortuosity (HP:0005116)1.57958979
137Pointed chin (HP:0000307)1.57881795
138Abnormality of the radial head (HP:0003995)1.57836138
139Germ cell neoplasia (HP:0100728)1.57832744
140Achilles tendon contracture (HP:0001771)1.56938087
141Cafe-au-lait spot (HP:0000957)1.56341529
142Arnold-Chiari malformation (HP:0002308)1.55855692
143Syringomyelia (HP:0003396)1.55534779
144Spinal cord lesions (HP:0100561)1.55534779
145Abnormal ossification of hand bones (HP:0005921)1.55532243
146Atelectasis (HP:0100750)1.55250837
147Trismus (HP:0000211)1.55109489
148Neuronal loss in central nervous system (HP:0002529)1.55082279
149Fibroma (HP:0010614)1.54697535
150Poikilocytosis (HP:0004447)1.54161352
151Glioma (HP:0009733)1.53610578
152Disproportionate tall stature (HP:0001519)1.53269615
153Patellar dislocation (HP:0002999)1.52462129
154Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.51641125
155Peritonitis (HP:0002586)1.51487908
156Inflammation of the large intestine (HP:0002037)1.51016179
157Bowel incontinence (HP:0002607)1.50872078
158Spinal cord compression (HP:0002176)1.50188914
159Impulsivity (HP:0100710)1.49763456
160Bone pain (HP:0002653)1.49750063
161Onion bulb formation (HP:0003383)1.49268096
162Decreased motor nerve conduction velocity (HP:0003431)1.49210001
163Hypochromic anemia (HP:0001931)1.49091871
164Medulloblastoma (HP:0002885)1.48737974
165Sparse lateral eyebrow (HP:0005338)1.48567007
166Bladder diverticulum (HP:0000015)1.48494138
167Upper motor neuron abnormality (HP:0002127)1.48148019
168Fibrous tissue neoplasm (HP:0012316)1.48116767
169Vascular tortuosity (HP:0004948)1.48022970
170Spinal rigidity (HP:0003306)1.47803570

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.40214430
2EEF2K4.16663860
3PRPF4B3.64139173
4TRIB33.63420871
5PKN23.58818787
6MAP3K103.56912719
7MAP4K12.18745426
8ERN12.12023857
9IRAK32.10586846
10RIPK41.92252460
11TTN1.90042612
12NEK21.84773056
13STK101.82615932
14ICK1.82448483
15LATS11.77887721
16PTK61.75494195
17CDC71.73588402
18CDK41.70221289
19MAP3K131.56687917
20ALK1.54924751
21KSR21.53415506
22SIK11.52728618
23RPS6KB21.49243909
24EPHA21.43065315
25RIPK11.42695739
26MTOR1.37131350
27BMX1.34665937
28GRK61.32377682
29FGFR41.31648761
30CDK61.30640443
31MARK21.24138578
32TAOK21.21637647
33PIM11.15935943
34IRAK41.15345433
35MAP3K71.13660699
36MAP3K11.12840216
37PAK41.11893197
38STK41.11253737
39MAP2K31.10615803
40PDGFRA1.09535934
41BRD41.08141899
42CDC42BPA1.06270103
43LRRK21.05668829
44JAK31.04882602
45MAP3K81.04720669
46TTK1.04457277
47PRKD21.03328828
48MST1R1.02198793
49TAOK11.01941762
50STK30.99589919
51NME20.98268375
52FGFR30.97499376
53SCYL20.97066132
54DMPK0.97043026
55CHUK0.96373648
56PDPK10.96001513
57EPHB10.93178428
58TYK20.87804175
59SIK20.87407647
60MAP3K110.87213042
61ARAF0.86735147
62CHEK10.84656386
63CDK70.84398521
64NEK10.81601731
65RPS6KA20.81470615
66IRAK20.79623768
67MAP3K20.79436379
68CAMK1D0.76736418
69RPS6KA40.76693001
70PASK0.75100591
71TBK10.75036299
72CSK0.74789086
73FLT30.73934578
74SGK30.72071010
75RET0.71885235
76ZAP700.71616148
77HIPK20.70947026
78ATR0.69711995
79TYRO30.68914872
80PAK20.65871833
81JAK10.64836678
82SIK30.64660667
83BLK0.64261864
84CAMK1G0.63721770
85MAP3K60.63163422
86PDK10.62409115
87MAP3K30.61979802
88MAP3K90.61569427
89JAK20.61565193
90LATS20.61249979
91PDGFRB0.61243211
92BTK0.60413874
93CDK20.60308334
94TGFBR20.60293794
95STK38L0.59635229
96CSF1R0.58767407
97MAPK110.56290030
98TSSK60.55460519
99LMTK20.54762186
100ATM0.54106764
101BRAF0.53941014
102TRPM70.53350123
103CAMKK10.52949040
104MAPKAPK30.52851299
105CDK90.52822818
106TESK20.52670058
107HCK0.52205169
108STK380.51887335
109TGFBR10.51855261
110TNK20.51269766
111MAPK120.51256303
112CLK10.48552807
113PRKCH0.48399294
114AURKB0.47074378
115PRKD30.46732450
116MAP3K140.46618755
117NTRK10.46094360
118RPS6KA10.45807109
119RPS6KA60.44996073
120RPS6KC10.44881620
121RPS6KL10.44881620
122AKT20.44058176
123CHEK20.43810728
124FGR0.43557036
125IKBKB0.42941191
126TESK10.42739188
127MARK30.42578376
128PRKG20.41213757
129FES0.41158333
130RAF10.39023158
131MAPK10.38676874
132PLK10.38081914
133CSNK1D0.37963610
134IKBKE0.37060787
135ITK0.36866478
136MELK0.36310038
137PTK20.36011017
138MAPK140.35357546
139FGFR10.35238961
140MAP2K20.33554005

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006702.30814259
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.21394755
3Lysine degradation_Homo sapiens_hsa003102.17811583
4Other glycan degradation_Homo sapiens_hsa005111.88482566
5Nitrogen metabolism_Homo sapiens_hsa009101.77715199
6Chronic myeloid leukemia_Homo sapiens_hsa052201.72660926
7Selenocompound metabolism_Homo sapiens_hsa004501.65449414
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.49575737
9Acute myeloid leukemia_Homo sapiens_hsa052211.48915165
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.48420947
11DNA replication_Homo sapiens_hsa030301.45977739
12Notch signaling pathway_Homo sapiens_hsa043301.42609635
13Renal cell carcinoma_Homo sapiens_hsa052111.41568041
14Small cell lung cancer_Homo sapiens_hsa052221.34984056
15Arginine biosynthesis_Homo sapiens_hsa002201.34880026
16Prion diseases_Homo sapiens_hsa050201.33937084
17Adherens junction_Homo sapiens_hsa045201.30140054
18MicroRNAs in cancer_Homo sapiens_hsa052061.26571932
19mTOR signaling pathway_Homo sapiens_hsa041501.25088046
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25040144
21Glioma_Homo sapiens_hsa052141.24127555
22B cell receptor signaling pathway_Homo sapiens_hsa046621.23585011
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23048629
24Hepatitis C_Homo sapiens_hsa051601.21757176
25ErbB signaling pathway_Homo sapiens_hsa040121.20287067
26Biosynthesis of amino acids_Homo sapiens_hsa012301.17109131
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.17055285
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.16905000
29Non-small cell lung cancer_Homo sapiens_hsa052231.16311638
30Viral carcinogenesis_Homo sapiens_hsa052031.14937653
31Cell cycle_Homo sapiens_hsa041101.14653270
32* RNA transport_Homo sapiens_hsa030131.13950824
33Antigen processing and presentation_Homo sapiens_hsa046121.11863347
34* mRNA surveillance pathway_Homo sapiens_hsa030151.10746555
35Insulin resistance_Homo sapiens_hsa049311.09811885
36HTLV-I infection_Homo sapiens_hsa051661.09714608
37Primary immunodeficiency_Homo sapiens_hsa053401.08361839
38Endometrial cancer_Homo sapiens_hsa052131.08341885
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07424199
40GnRH signaling pathway_Homo sapiens_hsa049121.06083731
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05952116
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04992699
43Staphylococcus aureus infection_Homo sapiens_hsa051501.04085766
44Herpes simplex infection_Homo sapiens_hsa051681.02662882
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02493164
46Phospholipase D signaling pathway_Homo sapiens_hsa040721.02315526
47Mismatch repair_Homo sapiens_hsa034301.02237926
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.01423502
49Spliceosome_Homo sapiens_hsa030401.00901400
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00440252
51TNF signaling pathway_Homo sapiens_hsa046681.00087282
52Viral myocarditis_Homo sapiens_hsa054160.99122908
53Choline metabolism in cancer_Homo sapiens_hsa052310.98484808
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.97645320
55Inositol phosphate metabolism_Homo sapiens_hsa005620.97141123
56Toxoplasmosis_Homo sapiens_hsa051450.96678828
57Estrogen signaling pathway_Homo sapiens_hsa049150.96091840
58Base excision repair_Homo sapiens_hsa034100.95999983
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95618472
60Fructose and mannose metabolism_Homo sapiens_hsa000510.95402044
61Bladder cancer_Homo sapiens_hsa052190.95197745
62Proteoglycans in cancer_Homo sapiens_hsa052050.94943622
63Measles_Homo sapiens_hsa051620.92969092
64Thyroid cancer_Homo sapiens_hsa052160.92933846
65Pancreatic cancer_Homo sapiens_hsa052120.92903242
66Apoptosis_Homo sapiens_hsa042100.91676152
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90396191
68Complement and coagulation cascades_Homo sapiens_hsa046100.89719705
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87080280
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86719936
71Tuberculosis_Homo sapiens_hsa051520.85705807
72T cell receptor signaling pathway_Homo sapiens_hsa046600.85111088
73p53 signaling pathway_Homo sapiens_hsa041150.84169024
74Endocytosis_Homo sapiens_hsa041440.83462773
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82983470
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.82864642
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82612884
78Shigellosis_Homo sapiens_hsa051310.82601621
79Caffeine metabolism_Homo sapiens_hsa002320.82543180
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81685111
81Leishmaniasis_Homo sapiens_hsa051400.81604872
82Osteoclast differentiation_Homo sapiens_hsa043800.81361532
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80081192
84Hepatitis B_Homo sapiens_hsa051610.79009303
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78273758
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78230731
87Carbon metabolism_Homo sapiens_hsa012000.78198569
88Prolactin signaling pathway_Homo sapiens_hsa049170.77266215
89Dorso-ventral axis formation_Homo sapiens_hsa043200.77183603
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76627287
91Pentose phosphate pathway_Homo sapiens_hsa000300.76423895
92Focal adhesion_Homo sapiens_hsa045100.76039928
93Long-term potentiation_Homo sapiens_hsa047200.75890173
94Chemokine signaling pathway_Homo sapiens_hsa040620.75879990
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.75057448
96Tryptophan metabolism_Homo sapiens_hsa003800.74577722
97Influenza A_Homo sapiens_hsa051640.74437218
98Fatty acid degradation_Homo sapiens_hsa000710.74158503
99Colorectal cancer_Homo sapiens_hsa052100.73157110
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.72984624
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72248843
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.71868236
103Salmonella infection_Homo sapiens_hsa051320.71814127
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71728365
105PPAR signaling pathway_Homo sapiens_hsa033200.71628632
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.71356883
107Galactose metabolism_Homo sapiens_hsa000520.71330189
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71226517
109AMPK signaling pathway_Homo sapiens_hsa041520.70550274
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70341700
111Systemic lupus erythematosus_Homo sapiens_hsa053220.69783945
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.67654571
113Prostate cancer_Homo sapiens_hsa052150.67447057
114HIF-1 signaling pathway_Homo sapiens_hsa040660.66737413
115Bile secretion_Homo sapiens_hsa049760.65247422
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64763345
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64635307
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64332285
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.64111801
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63137746
121Platelet activation_Homo sapiens_hsa046110.63133610
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63015870
123Malaria_Homo sapiens_hsa051440.62459371
124VEGF signaling pathway_Homo sapiens_hsa043700.61253972
125Hippo signaling pathway_Homo sapiens_hsa043900.61199812
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.61025328
127Legionellosis_Homo sapiens_hsa051340.60626054
128Insulin signaling pathway_Homo sapiens_hsa049100.60571155
129Type II diabetes mellitus_Homo sapiens_hsa049300.60270620
130ABC transporters_Homo sapiens_hsa020100.59288990
131Basal cell carcinoma_Homo sapiens_hsa052170.59089073
132FoxO signaling pathway_Homo sapiens_hsa040680.58802100
133Sulfur relay system_Homo sapiens_hsa041220.58413963
134Fat digestion and absorption_Homo sapiens_hsa049750.57915654
135Epstein-Barr virus infection_Homo sapiens_hsa051690.56839093
136Rap1 signaling pathway_Homo sapiens_hsa040150.56752621
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56280430
138Amoebiasis_Homo sapiens_hsa051460.55703344
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54539654
140Pathways in cancer_Homo sapiens_hsa052000.54388297
141Lysosome_Homo sapiens_hsa041420.52158903
142MAPK signaling pathway_Homo sapiens_hsa040100.51321922
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50897647
144ECM-receptor interaction_Homo sapiens_hsa045120.47782203

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »