UOX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.63863668
2L-phenylalanine catabolic process (GO:0006559)7.63863668
3L-phenylalanine metabolic process (GO:0006558)7.28977786
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.28977786
5aromatic amino acid family catabolic process (GO:0009074)6.90094751
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.25940628
7tryptophan catabolic process (GO:0006569)6.24298527
8indole-containing compound catabolic process (GO:0042436)6.24298527
9indolalkylamine catabolic process (GO:0046218)6.24298527
10kynurenine metabolic process (GO:0070189)6.10131881
11bile acid biosynthetic process (GO:0006699)6.01128369
12tryptophan metabolic process (GO:0006568)5.87243507
13urea metabolic process (GO:0019627)5.75965508
14urea cycle (GO:0000050)5.75965508
15glyoxylate metabolic process (GO:0046487)5.75360307
16alpha-linolenic acid metabolic process (GO:0036109)5.65261111
17positive regulation of catecholamine secretion (GO:0033605)5.64054143
18negative regulation of fibrinolysis (GO:0051918)5.59041627
19high-density lipoprotein particle remodeling (GO:0034375)5.51469351
20tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.50097105
21RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.50097105
22regulation of plasminogen activation (GO:0010755)5.43163711
23complement activation, alternative pathway (GO:0006957)5.42417150
24regulation of fibrinolysis (GO:0051917)5.39836680
25protein carboxylation (GO:0018214)5.38609715
26peptidyl-glutamic acid carboxylation (GO:0017187)5.38609715
27regulation of protein activation cascade (GO:2000257)5.38077154
28cysteine metabolic process (GO:0006534)5.35433205
29sulfur amino acid catabolic process (GO:0000098)5.33824948
30nitrogen cycle metabolic process (GO:0071941)5.29383252
31regulation of oxidative phosphorylation (GO:0002082)5.16432262
32serine family amino acid catabolic process (GO:0009071)5.13610465
33bile acid metabolic process (GO:0008206)5.13424107
34regulation of autophagic vacuole assembly (GO:2000785)5.07350049
35regulation of complement activation (GO:0030449)5.03539930
36aromatic amino acid family metabolic process (GO:0009072)5.00907119
37folic acid-containing compound biosynthetic process (GO:0009396)4.99501581
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.87651818
39homocysteine metabolic process (GO:0050667)4.86904983
40positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.86509593
41tyrosine metabolic process (GO:0006570)4.84811653
42regulation of cholesterol esterification (GO:0010872)4.82697164
43regulation of triglyceride catabolic process (GO:0010896)4.81563973
44microtubule nucleation (GO:0007020)4.79693624
45reverse cholesterol transport (GO:0043691)4.78906498
46cellular response to zinc ion (GO:0071294)4.77262395
47plasma lipoprotein particle remodeling (GO:0034369)4.73119437
48protein-lipid complex remodeling (GO:0034368)4.73119437
49macromolecular complex remodeling (GO:0034367)4.73119437
50pteridine-containing compound biosynthetic process (GO:0042559)4.72651314
51alpha-amino acid catabolic process (GO:1901606)4.68457415
52organic cation transport (GO:0015695)4.67047292
53desmosome organization (GO:0002934)4.64204710
54lysine catabolic process (GO:0006554)4.62166327
55lysine metabolic process (GO:0006553)4.62166327
56amino-acid betaine metabolic process (GO:0006577)4.61818969
57retinal cone cell development (GO:0046549)4.60225916
58triglyceride homeostasis (GO:0070328)4.59623087
59acylglycerol homeostasis (GO:0055090)4.59623087
60negative regulation of cholesterol transport (GO:0032375)4.56690855
61negative regulation of sterol transport (GO:0032372)4.56690855
62phospholipid efflux (GO:0033700)4.52341955
63SMAD protein complex assembly (GO:0007183)4.51486542
64galactose catabolic process (GO:0019388)4.50068039
65regulation of oxidative stress-induced neuron death (GO:1903203)4.45849582
66bile acid and bile salt transport (GO:0015721)4.45570303
67coenzyme catabolic process (GO:0009109)4.43638348
68glycine metabolic process (GO:0006544)4.42990864
69indolalkylamine metabolic process (GO:0006586)4.42172775
70cellular ketone body metabolic process (GO:0046950)4.40674613
71imidazole-containing compound metabolic process (GO:0052803)4.39571038
72cell migration involved in heart development (GO:0060973)4.38318346
73kidney morphogenesis (GO:0060993)4.36466718
74amine catabolic process (GO:0009310)4.33679975
75cellular biogenic amine catabolic process (GO:0042402)4.33679975
76cellular glucuronidation (GO:0052695)4.33526171
77plasma lipoprotein particle clearance (GO:0034381)4.33372696
78cellular amino acid catabolic process (GO:0009063)4.30013793
79regulation of phosphoprotein phosphatase activity (GO:0043666)4.27130454
80glutamate metabolic process (GO:0006536)4.25888332
81zinc ion transmembrane transport (GO:0071577)4.25496366
82cholesterol efflux (GO:0033344)4.20363662
83mRNA cleavage (GO:0006379)4.19332762
84serine family amino acid metabolic process (GO:0009069)4.19205507
85benzene-containing compound metabolic process (GO:0042537)4.14062827
86regulation of vacuole organization (GO:0044088)4.13945074
87ethanol oxidation (GO:0006069)4.12491201
88cellular modified amino acid catabolic process (GO:0042219)4.06489054
89dicarboxylic acid biosynthetic process (GO:0043650)4.06318836
90peptidyl-histidine modification (GO:0018202)4.05257687
91arginine metabolic process (GO:0006525)4.04846928
92phosphate ion transport (GO:0006817)4.02216973
93serine family amino acid biosynthetic process (GO:0009070)4.00613728
94fibrinolysis (GO:0042730)4.00606580
95low-density lipoprotein particle remodeling (GO:0034374)4.00381060
96aldehyde catabolic process (GO:0046185)3.99192413
97galactose metabolic process (GO:0006012)3.96345430
98plasma lipoprotein particle assembly (GO:0034377)3.96278402
99inner ear receptor cell development (GO:0060119)3.94929674
100drug catabolic process (GO:0042737)3.92418401
101protein hydroxylation (GO:0018126)3.88028135
102pancreas development (GO:0031016)3.86549096
103insulin secretion (GO:0030073)3.86354445
104negative regulation of meiotic cell cycle (GO:0051447)3.85165107
105blood coagulation, intrinsic pathway (GO:0007597)3.84854170
106uronic acid metabolic process (GO:0006063)3.84728364
107glucuronate metabolic process (GO:0019585)3.84728364
108phosphate ion transmembrane transport (GO:0035435)3.84523563
109cofactor catabolic process (GO:0051187)3.82378343
110ketone body metabolic process (GO:1902224)3.81456581
111complement activation, classical pathway (GO:0006958)3.80837563
112regulation of bile acid biosynthetic process (GO:0070857)3.80058902
113complement activation (GO:0006956)3.77440077
114very-low-density lipoprotein particle assembly (GO:0034379)3.76565854
115positive regulation of lipid catabolic process (GO:0050996)3.75702865
116phospholipid homeostasis (GO:0055091)3.75314651
117organic acid catabolic process (GO:0016054)3.75136840
118carboxylic acid catabolic process (GO:0046395)3.75136840
119negative regulation of lipase activity (GO:0060192)3.74581268
120protein activation cascade (GO:0072376)3.74190096
121cytolysis (GO:0019835)3.74003234
122cholesterol homeostasis (GO:0042632)3.72937559
123acetyl-CoA metabolic process (GO:0006084)3.72421590
124positive regulation of triglyceride lipase activity (GO:0061365)3.71875630
125positive regulation of lipoprotein lipase activity (GO:0051006)3.71875630
126cellular response to cadmium ion (GO:0071276)3.68322182
127sterol homeostasis (GO:0055092)3.66687785
128short-chain fatty acid metabolic process (GO:0046459)3.65217163
129regulation of cholesterol homeostasis (GO:2000188)3.63800469
130cell fate commitment involved in formation of primary germ layer (GO:0060795)3.59325899
131plasma lipoprotein particle organization (GO:0071827)3.58825625
132NAD biosynthetic process (GO:0009435)3.57583524
133epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.56859624
134multicellular organism reproduction (GO:0032504)3.56620475
135cilium or flagellum-dependent cell motility (GO:0001539)3.56160935
136protein-lipid complex assembly (GO:0065005)3.54975769
137nicotinamide nucleotide biosynthetic process (GO:0019359)3.54655266
138positive regulation of actin filament depolymerization (GO:0030836)3.51859887
139male meiosis (GO:0007140)3.49061546
140activation of protein kinase A activity (GO:0034199)3.42544883
141cardiac muscle cell proliferation (GO:0060038)3.42485265
142regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.40012547
143positive regulation of endothelial cell differentiation (GO:0045603)3.35534721
144primary amino compound metabolic process (GO:1901160)3.35066889
145polyamine biosynthetic process (GO:0006596)3.34646377
146adenosine metabolic process (GO:0046085)3.33811521
147positive regulation of TOR signaling (GO:0032008)3.19266496
148white fat cell differentiation (GO:0050872)3.18720657
149acrosome reaction (GO:0007340)3.15887484
150negative regulation of response to extracellular stimulus (GO:0032105)3.15417851
151negative regulation of response to nutrient levels (GO:0032108)3.15417851
152response to lead ion (GO:0010288)3.14667488
153regulation of gonadotropin secretion (GO:0032276)3.12664280
154regulation of cellular respiration (GO:0043457)3.12442865
155positive regulation of myoblast differentiation (GO:0045663)3.11849412
156regulation of response to food (GO:0032095)3.10512335
157potassium ion export (GO:0071435)3.08926863
158response to BMP (GO:0071772)3.08817135
159cellular response to BMP stimulus (GO:0071773)3.08817135
160fatty acid beta-oxidation (GO:0006635)3.07409402
161sperm motility (GO:0030317)3.06647023
162potassium ion import (GO:0010107)3.05669764
163homeostasis of number of cells within a tissue (GO:0048873)3.04224658
1644-hydroxyproline metabolic process (GO:0019471)3.03479261
165nucleoside diphosphate biosynthetic process (GO:0009133)3.01202574
166rRNA methylation (GO:0031167)3.00569303
167innervation (GO:0060384)2.99137380
168energy homeostasis (GO:0097009)2.97139354
169purine nucleotide salvage (GO:0032261)2.96821222
170regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.96490544
171indole-containing compound metabolic process (GO:0042430)2.96079423
172cartilage morphogenesis (GO:0060536)2.95364063
173negative regulation of macrophage differentiation (GO:0045650)2.93420855
174negative regulation of DNA biosynthetic process (GO:2000279)2.92699439
175cGMP-mediated signaling (GO:0019934)2.90893127
176androgen biosynthetic process (GO:0006702)2.90411784
177gluconeogenesis (GO:0006094)2.82959870
178peptide hormone secretion (GO:0030072)2.82174449
179spermatid development (GO:0007286)2.79054970
180hexose biosynthetic process (GO:0019319)2.77132932
181retinol metabolic process (GO:0042572)2.76786050
182regulation of synaptic transmission, dopaminergic (GO:0032225)2.76504085
183striated muscle cell proliferation (GO:0014855)2.75400580
184maintenance of protein location in nucleus (GO:0051457)2.73688572
185TOR signaling (GO:0031929)2.73624579
186single fertilization (GO:0007338)2.72390565
187nucleoside transport (GO:0015858)2.72309486
188peptide secretion (GO:0002790)2.71920285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.42041785
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.20032128
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.10040631
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.53399797
5* FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.24374093
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.12640742
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.79681991
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.07870410
9* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.91519226
10ZNF274_21170338_ChIP-Seq_K562_Hela2.69208755
11GBX2_23144817_ChIP-Seq_PC3_Human2.47971117
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.41304867
13VDR_22108803_ChIP-Seq_LS180_Human2.39109982
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.10689975
15AR_21572438_ChIP-Seq_LNCaP_Human2.09441598
16* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9370944
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96204947
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95955289
19FUS_26573619_Chip-Seq_HEK293_Human1.90849236
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87865685
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85715910
22BP1_19119308_ChIP-ChIP_Hs578T_Human1.75318252
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74600362
24OCT1_27270436_Chip-Seq_PROSTATE_Human1.64707145
25FOXA2_19822575_ChIP-Seq_HepG2_Human1.62172433
26LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61066043
27HTT_18923047_ChIP-ChIP_STHdh_Human1.59473701
28CLOCK_20551151_ChIP-Seq_293T_Human1.55653590
29TP53_22573176_ChIP-Seq_HFKS_Human1.50121033
30CDX2_22108803_ChIP-Seq_LS180_Human1.48357662
31GATA1_22025678_ChIP-Seq_K562_Human1.46356373
32KLF5_20875108_ChIP-Seq_MESCs_Mouse1.44470216
33* PHF8_20622853_ChIP-Seq_HELA_Human1.43408789
34HNF4A_19822575_ChIP-Seq_HepG2_Human1.41207952
35ER_23166858_ChIP-Seq_MCF-7_Human1.35675802
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34358906
37NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31969587
38VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.31077938
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26942759
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26470651
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25520221
42TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.24956515
43* TBL1_22424771_ChIP-Seq_293T_Human1.23020767
44CBP_20019798_ChIP-Seq_JUKART_Human1.22901378
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22901378
46AHR_22903824_ChIP-Seq_MCF-7_Human1.21776795
47RUNX2_22187159_ChIP-Seq_PCA_Human1.21367623
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20264031
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19551308
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.18844211
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17803648
52STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17780364
53IGF1R_20145208_ChIP-Seq_DFB_Human1.17275499
54* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17189304
55* NFYA_21822215_ChIP-Seq_K562_Human1.15706100
56* HNFA_21074721_ChIP-Seq_CACO-2_Human1.13767620
57* NFYB_21822215_ChIP-Seq_K562_Human1.13341234
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13087151
59* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.09743443
60* ETV1_20927104_ChIP-Seq_GIST48_Human1.09065629
61* SMAD4_21741376_ChIP-Seq_EPCs_Human1.08549292
62SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07389236
63NANOG_20526341_ChIP-Seq_ESCs_Human1.06168496
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05993890
65P300_19829295_ChIP-Seq_ESCs_Human1.04679380
66* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04312680
67SMAD4_21741376_ChIP-Seq_ESCs_Human1.04253103
68CTCF_27219007_Chip-Seq_Bcells_Human1.03499163
69STAT3_23295773_ChIP-Seq_U87_Human1.03199700
70HOXB7_26014856_ChIP-Seq_BT474_Human1.02732703
71OCT4_20526341_ChIP-Seq_ESCs_Human1.02659890
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01731167
73ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00769068
74CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00459505
75* GATA6_21074721_ChIP-Seq_CACO-2_Human0.99814714
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99113639
77* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.97737247
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97478013
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97284107
80EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97199265
81RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97199265
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96331801
83PRDM14_20953172_ChIP-Seq_ESCs_Human0.95234351
84EP300_21415370_ChIP-Seq_HL-1_Mouse0.94293198
85RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94201175
86ERA_21632823_ChIP-Seq_H3396_Human0.93165539
87* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.92625322
88SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92371586
89FLI1_21867929_ChIP-Seq_CD8_Mouse0.92287338
90YY1_22570637_ChIP-Seq_MALME-3M_Human0.91705173
91SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91637315
92TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91551240
93* RBPJ_21746931_ChIP-Seq_IB4_Human0.91404751
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91275827
95EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90575100
96NANOG_19829295_ChIP-Seq_ESCs_Human0.90534870
97SOX2_19829295_ChIP-Seq_ESCs_Human0.90534870
98P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89683752
99PIAS1_25552417_ChIP-Seq_VCAP_Human0.88262186
100RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88037756
101EED_16625203_ChIP-ChIP_MESCs_Mouse0.87976697
102AR_25329375_ChIP-Seq_VCAP_Human0.86757925
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86427934
104RAC3_21632823_ChIP-Seq_H3396_Human0.86426405
105FOXH1_21741376_ChIP-Seq_ESCs_Human0.86199275
106AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85189217
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84846282
108SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.84334007
109IRF8_22096565_ChIP-ChIP_GC-B_Human0.84308796
110SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83779226
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83187161
112BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82614041
113POU3F2_20337985_ChIP-ChIP_501MEL_Human0.82198298
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81998626
115SCL_19346495_ChIP-Seq_HPC-7_Human0.81958229
116EZH2_27294783_Chip-Seq_NPCs_Mouse0.81732412
117RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80609199
118GATA4_25053715_ChIP-Seq_YYC3_Human0.80063377
119TET1_21490601_ChIP-Seq_MESCs_Mouse0.79710505
120CTCF_20526341_ChIP-Seq_ESCs_Human0.79525542
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78185729
122ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77626709
123SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77240102
124KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77169455
125Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.74898356
126RARA_24833708_ChIP-Seq_LIVER_Mouse0.73373962
127SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72888731
128CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71467525
129ZNF263_19887448_ChIP-Seq_K562_Human0.70953477
130AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69441731
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.67045862
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.67045862
133ESR2_21235772_ChIP-Seq_MCF-7_Human0.64010328
134* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.63778506
135RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63511090
136RARB_24833708_ChIP-Seq_LIVER_Mouse0.62902193
137RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60400804
138BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59208917
139NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.58985990
140NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.58105835
141CEBPB_22108803_ChIP-Seq_LS180_Human0.57601117
142NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.56711703
143FOXA1_25552417_ChIP-Seq_VCAP_Human0.54129728
144EGR1_19032775_ChIP-ChIP_M12_Human0.53791959
145TAF15_26573619_Chip-Seq_HEK293_Human0.53206061
146FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52809454
147AR_20517297_ChIP-Seq_VCAP_Human0.52766151
148PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51686600
149FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51644907
150E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.49843150
151CBP_21632823_ChIP-Seq_H3396_Human0.49655759
152LXR_22292898_ChIP-Seq_THP-1_Human0.49481602
153ESET_19884257_ChIP-Seq_ESCs_Mouse0.48924486
154STAT3_1855785_ChIP-Seq_MESCs_Mouse0.48841354
155STAT1_17558387_ChIP-Seq_HELA_Human0.48794114
156* MYC_19915707_ChIP-ChIP_AK7_Human0.48699198
157PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46338739
158FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.45750006
159CDX2_20551321_ChIP-Seq_CACO-2_Human0.44450114
160* P53_21459846_ChIP-Seq_SAOS-2_Human0.43916524
161PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43177141
162ESR1_21235772_ChIP-Seq_MCF-7_Human0.43136906
163PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43017161
164CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.42228866
165FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41896034
166FOXO3_23340844_ChIP-Seq_DLD1_Human0.41252801
167BCAT_22108803_ChIP-Seq_LS180_Human0.41188007
168TAF2_19829295_ChIP-Seq_ESCs_Human0.40592001
169GATA1_19941826_ChIP-Seq_K562_Human0.39981014
170ESR1_20079471_ChIP-ChIP_T-47D_Human0.39733670
171GATA1_19941827_ChIP-Seq_MEL_Mouse0.39596738
172PPAR_26484153_Chip-Seq_NCI-H1993_Human0.39539122
173SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39234850
174GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.39195904
175GATA2_19941826_ChIP-Seq_K562_Human0.38850318
176ERG_21242973_ChIP-ChIP_JURKAT_Human0.38489592
177GATA6_25053715_ChIP-Seq_YYC3_Human0.37829415
178SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.37657007
179STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37456302
180MYC_27129775_Chip-Seq_CORNEA_Mouse0.37003866
181LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36038713
182NCOR_22424771_ChIP-Seq_293T_Human0.34764617
183SPI1_26923725_Chip-Seq_HPCs_Mouse0.34502638
184ERG_20517297_ChIP-Seq_VCAP_Human0.34496878
185BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.34350361
186FOXH1_21741376_ChIP-Seq_EPCs_Human0.34340499

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.46519033
2* MP0005360_urolithiasis6.80838265
3MP0005085_abnormal_gallbladder_physiolo6.62700824
4MP0005365_abnormal_bile_salt6.29183123
5MP0008875_abnormal_xenobiotic_pharmacok5.25648953
6MP0004043_abnormal_pH_regulation5.23074723
7MP0003806_abnormal_nucleotide_metabolis4.29438385
8MP0003252_abnormal_bile_duct4.01433597
9MP0000013_abnormal_adipose_tissue4.00697531
10MP0005646_abnormal_pituitary_gland3.80492909
11MP0010329_abnormal_lipoprotein_level3.63322763
12MP0005410_abnormal_fertilization3.39089016
13MP0009840_abnormal_foam_cell3.28370791
14MP0005083_abnormal_biliary_tract3.12790028
15MP0001984_abnormal_olfaction3.03355081
16MP0004885_abnormal_endolymph2.94247443
17MP0003195_calcinosis2.87865763
18MP0003315_abnormal_perineum_morphology2.73884391
19* MP0005332_abnormal_amino_acid2.70344991
20MP0003136_yellow_coat_color2.64375911
21MP0001666_abnormal_nutrient_absorption2.63003688
22MP0002132_abnormal_respiratory_system2.50659176
23MP0002909_abnormal_adrenal_gland2.48955027
24MP0001664_abnormal_digestion2.31029161
25MP0003191_abnormal_cellular_cholesterol2.27234815
26MP0010234_abnormal_vibrissa_follicle2.23218180
27MP0000609_abnormal_liver_physiology2.20003632
28MP0008004_abnormal_stomach_pH2.16973017
29MP0004019_abnormal_vitamin_homeostasis2.16036962
30MP0000749_muscle_degeneration2.13598696
31MP0002118_abnormal_lipid_homeostasis2.13553879
32MP0001944_abnormal_pancreas_morphology2.07141039
33MP0002138_abnormal_hepatobiliary_system2.00242361
34MP0003868_abnormal_feces_composition1.99183865
35MP0002736_abnormal_nociception_after1.92852129
36MP0008995_early_reproductive_senescence1.89788539
37MP0005319_abnormal_enzyme/_coenzyme1.85990942
38MP0001905_abnormal_dopamine_level1.81377781
39MP0001270_distended_abdomen1.79168268
40MP0002160_abnormal_reproductive_system1.75690418
41MP0003045_fibrosis1.72865607
42MP0008961_abnormal_basal_metabolism1.72084560
43MP0001764_abnormal_homeostasis1.70358939
44MP0001968_abnormal_touch/_nociception1.68104754
45MP0009697_abnormal_copulation1.64067941
46MP0002938_white_spotting1.63709574
47MP0005584_abnormal_enzyme/coenzyme_acti1.58894639
48MP0002234_abnormal_pharynx_morphology1.54444701
49MP0005499_abnormal_olfactory_system1.45297034
50MP0005394_taste/olfaction_phenotype1.45297034
51MP0005451_abnormal_body_composition1.43269589
52MP0003011_delayed_dark_adaptation1.41154644
53MP0003633_abnormal_nervous_system1.34146682
54MP0003186_abnormal_redox_activity1.28249902
55MP0003656_abnormal_erythrocyte_physiolo1.27323126
56MP0001929_abnormal_gametogenesis1.27023465
57MP0004084_abnormal_cardiac_muscle1.26008255
58MP0003698_abnormal_male_reproductive1.24015803
59MP0003183_abnormal_peptide_metabolism1.23388439
60MP0004147_increased_porphyrin_level1.20550263
61MP0000598_abnormal_liver_morphology1.19928644
62* MP0009643_abnormal_urine_homeostasis1.18175215
63MP0005647_abnormal_sex_gland1.16102576
64MP0003705_abnormal_hypodermis_morpholog1.15293978
65MP0000003_abnormal_adipose_tissue1.13973640
66MP0005171_absent_coat_pigmentation1.12324350
67MP0005551_abnormal_eye_electrophysiolog1.11889550
68MP0002095_abnormal_skin_pigmentation1.11646902
69MP0005253_abnormal_eye_physiology1.11135753
70MP0009764_decreased_sensitivity_to1.07372914
71MP0000604_amyloidosis1.06971099
72MP0004085_abnormal_heartbeat1.06138964
73MP0002254_reproductive_system_inflammat1.04698737
74MP0004233_abnormal_muscle_weight1.04598687
75MP0004510_myositis1.03842702
76MP0009763_increased_sensitivity_to1.03752944
77MP0006072_abnormal_retinal_apoptosis1.01762502
78MP0001765_abnormal_ion_homeostasis1.00715269
79MP0000470_abnormal_stomach_morphology0.98087049
80MP0005379_endocrine/exocrine_gland_phen0.98015135
81MP0005377_hearing/vestibular/ear_phenot0.97597010
82MP0003878_abnormal_ear_physiology0.97597010
83MP0008789_abnormal_olfactory_epithelium0.95340056
84MP0010368_abnormal_lymphatic_system0.95215299
85MP0001145_abnormal_male_reproductive0.95172257
86MP0000653_abnormal_sex_gland0.92182314
87MP0005636_abnormal_mineral_homeostasis0.91985456
88MP0000372_irregular_coat_pigmentation0.91796824
89MP0003631_nervous_system_phenotype0.91704202
90MP0002210_abnormal_sex_determination0.90620124
91MP0002733_abnormal_thermal_nociception0.90400861
92MP0002108_abnormal_muscle_morphology0.90284405
93MP0004134_abnormal_chest_morphology0.90121528
94MP0002269_muscular_atrophy0.90010940
95MP0008469_abnormal_protein_level0.89789450
96MP0005670_abnormal_white_adipose0.87761272
97MP0005167_abnormal_blood-brain_barrier0.87176031
98* MP0009642_abnormal_blood_homeostasis0.86919058
99MP0002233_abnormal_nose_morphology0.86751018
100MP0009250_abnormal_appendicular_skeleto0.86750677
101MP0005408_hypopigmentation0.86640170
102MP0000516_abnormal_urinary_system0.86006665
103MP0005367_renal/urinary_system_phenotyp0.86006665
104MP0000631_abnormal_neuroendocrine_gland0.85923072
105MP0001970_abnormal_pain_threshold0.85728840
106MP0002184_abnormal_innervation0.84014964
107MP0005389_reproductive_system_phenotype0.83816982
108MP0003936_abnormal_reproductive_system0.83254514
109MP0004036_abnormal_muscle_relaxation0.83168640
110MP0003937_abnormal_limbs/digits/tail_de0.83121459
111MP0006036_abnormal_mitochondrial_physio0.82469751
112MP0005330_cardiomyopathy0.82022506
113MP0000026_abnormal_inner_ear0.81740069
114MP0005376_homeostasis/metabolism_phenot0.80879663
115MP0002272_abnormal_nervous_system0.80818604
116MP0010386_abnormal_urinary_bladder0.80744526
117MP0005174_abnormal_tail_pigmentation0.80093977
118MP0009765_abnormal_xenobiotic_induced0.79932380
119MP0000569_abnormal_digit_pigmentation0.79880038
120MP0005084_abnormal_gallbladder_morpholo0.79024912
121MP0002078_abnormal_glucose_homeostasis0.78968020
122MP0004215_abnormal_myocardial_fiber0.78917060
123MP0004145_abnormal_muscle_electrophysio0.78655163
124MP0002876_abnormal_thyroid_physiology0.78297615
125MP0001486_abnormal_startle_reflex0.77946771
126MP0002102_abnormal_ear_morphology0.76603081
127MP0003935_abnormal_craniofacial_develop0.75719619
128MP0005220_abnormal_exocrine_pancreas0.75012594
129MP0004130_abnormal_muscle_cell0.73270086
130MP0002971_abnormal_brown_adipose0.72997282
131MP0005334_abnormal_fat_pad0.70793270
132MP0003690_abnormal_glial_cell0.69286849
133MP0005535_abnormal_body_temperature0.68208320
134MP0001661_extended_life_span0.68125746
135MP0005266_abnormal_metabolism0.66127899
136MP0009053_abnormal_anal_canal0.65420698
137MP0003329_amyloid_beta_deposits0.62462503
138MP0000639_abnormal_adrenal_gland0.61367107
139MP0006035_abnormal_mitochondrial_morpho0.57800331
140MP0005448_abnormal_energy_balance0.56013974
141MP0005464_abnormal_platelet_physiology0.51933533
142MP0002822_catalepsy0.49972526
143MP0005395_other_phenotype0.48895417
144MP0002928_abnormal_bile_duct0.48138817
145MP0008874_decreased_physiological_sensi0.47067408
146MP0003638_abnormal_response/metabolism_0.46902672
147MP0003718_maternal_effect0.46538380
148MP0008873_increased_physiological_sensi0.45603071
149MP0004782_abnormal_surfactant_physiolog0.43863361
150MP0003724_increased_susceptibility_to0.43657236
151* MP0001756_abnormal_urination0.43498545
152MP0004381_abnormal_hair_follicle0.42311154
153MP0002837_dystrophic_cardiac_calcinosis0.41917956
154MP0003436_decreased_susceptibility_to0.41852032
155MP0003953_abnormal_hormone_level0.41155548
156MP0005248_abnormal_Harderian_gland0.41136724
157* MP0002136_abnormal_kidney_physiology0.40068124
158MP0003075_altered_response_to0.40010379
159MP0005666_abnormal_adipose_tissue0.39027011
160MP0000579_abnormal_nail_morphology0.38976260
161MP0005166_decreased_susceptibility_to0.38571884
162MP0008872_abnormal_physiological_respon0.38539138
163MP0009672_abnormal_birth_weight0.37792115
164MP0009384_cardiac_valve_regurgitation0.34451024
165MP0002796_impaired_skin_barrier0.33387444
166MP0009115_abnormal_fat_cell0.33382240
167MP0001853_heart_inflammation0.32582339
168MP0001243_abnormal_dermal_layer0.32339495
169MP0000230_abnormal_systemic_arterial0.32247270
170MP0002168_other_aberrant_phenotype0.31785604
171MP0000249_abnormal_blood_vessel0.31541642
172MP0002970_abnormal_white_adipose0.30936895
173MP0004883_abnormal_blood_vessel0.30367770
174MP0006082_CNS_inflammation0.29357893
175MP0001881_abnormal_mammary_gland0.28961148
176MP0002090_abnormal_vision0.27485557
177MP0002060_abnormal_skin_morphology0.25904567
178* MP0001845_abnormal_inflammatory_respons0.25094097
179MP0005164_abnormal_response_to0.24212261
180MP0000427_abnormal_hair_cycle0.23340770

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.47215087
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.46928722
3Intrahepatic cholestasis (HP:0001406)7.37427454
4Reduced antithrombin III activity (HP:0001976)6.99346070
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.76288030
6Prolonged partial thromboplastin time (HP:0003645)6.64475413
7Abnormality of alanine metabolism (HP:0010916)6.63614559
8Hyperalaninemia (HP:0003348)6.63614559
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)6.63614559
10Hypobetalipoproteinemia (HP:0003563)6.49631525
11Xanthomatosis (HP:0000991)6.28332895
12Tongue fasciculations (HP:0001308)5.77183764
13Hyperlipoproteinemia (HP:0010980)5.58602226
14Complement deficiency (HP:0004431)5.48251423
15Muscle fibrillation (HP:0010546)5.13990231
16Hypolipoproteinemia (HP:0010981)4.81997998
17Joint hemorrhage (HP:0005261)4.80305271
18Hyperammonemia (HP:0001987)4.61923667
19Epidermoid cyst (HP:0200040)4.59312742
20Renal tubular acidosis (HP:0001947)4.50898626
21Abnormality of the common coagulation pathway (HP:0010990)4.45944282
22Proximal tubulopathy (HP:0000114)4.43119539
23Hyperglycinemia (HP:0002154)4.42082200
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.40978182
25Abnormality of methionine metabolism (HP:0010901)4.34848872
26Abnormality of sulfur amino acid metabolism (HP:0004339)4.27031288
27Ketosis (HP:0001946)4.26982893
28Severe muscular hypotonia (HP:0006829)4.23368243
29Hypoalphalipoproteinemia (HP:0003233)4.18128023
30Abnormality of glutamine family amino acid metabolism (HP:0010902)4.16321673
31Abnormality of aspartate family amino acid metabolism (HP:0010899)4.16119703
32Fat malabsorption (HP:0002630)4.15464669
33Action tremor (HP:0002345)4.01003542
34Abnormality of complement system (HP:0005339)3.99655896
35Abnormality of pyrimidine metabolism (HP:0004353)3.91179711
36Abnormality of serine family amino acid metabolism (HP:0010894)3.88614069
37Abnormality of glycine metabolism (HP:0010895)3.88614069
38Hyperglycinuria (HP:0003108)3.88440797
39Hypoglycemic coma (HP:0001325)3.82510377
40Conjugated hyperbilirubinemia (HP:0002908)3.80074214
41Abnormality of the intrinsic pathway (HP:0010989)3.78218488
42Arthropathy (HP:0003040)3.77593916
43Congenital sensorineural hearing impairment (HP:0008527)3.77045783
44Cerebellar dysplasia (HP:0007033)3.73877996
45Spontaneous hematomas (HP:0007420)3.69326466
46Hypercholesterolemia (HP:0003124)3.66038512
47Resting tremor (HP:0002322)3.64432164
48Nausea (HP:0002018)3.56583459
49Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.37363741
50Hyperbilirubinemia (HP:0002904)3.36668479
51Menstrual irregularities (HP:0000858)3.35891987
52Type I transferrin isoform profile (HP:0003642)3.35293418
53Abnormality of fatty-acid metabolism (HP:0004359)3.30692000
54Steatorrhea (HP:0002570)3.13345670
55Delayed CNS myelination (HP:0002188)3.11614872
56Abnormality of serum amino acid levels (HP:0003112)3.09430977
57Abnormality of nucleobase metabolism (HP:0010932)3.07360672
58Constricted visual fields (HP:0001133)3.07287782
59Ketoacidosis (HP:0001993)2.98823947
60Hepatocellular carcinoma (HP:0001402)2.98687960
61Spontaneous abortion (HP:0005268)2.98619364
62Hypochromic microcytic anemia (HP:0004840)2.97085081
63Myocardial infarction (HP:0001658)2.96795691
64Renal dysplasia (HP:0000110)2.95490055
65Skin nodule (HP:0200036)2.83862208
66Systemic lupus erythematosus (HP:0002725)2.76297361
67Hypomagnesemia (HP:0002917)2.75307156
68Metabolic acidosis (HP:0001942)2.73395069
69Abnormality of purine metabolism (HP:0004352)2.65451153
70Ventricular fibrillation (HP:0001663)2.63719947
71Acanthocytosis (HP:0001927)2.60601657
72Lethargy (HP:0001254)2.60284718
73Vascular calcification (HP:0004934)2.56205019
74Pachygyria (HP:0001302)2.54238139
75Abnormality of dicarboxylic acid metabolism (HP:0010995)2.53424329
76Dicarboxylic aciduria (HP:0003215)2.53424329
77Type II lissencephaly (HP:0007260)2.53267393
78Short hallux (HP:0010109)2.52947639
79Abnormality of magnesium homeostasis (HP:0004921)2.52917957
80Decreased electroretinogram (ERG) amplitude (HP:0000654)2.52836906
81Abnormal gallbladder morphology (HP:0012437)2.50796242
82White forelock (HP:0002211)2.50518646
83Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.50460041
84Spastic diplegia (HP:0001264)2.48327390
85Hypoglycemic seizures (HP:0002173)2.47505091
86Spastic paraparesis (HP:0002313)2.46879653
87Rhabdomyolysis (HP:0003201)2.46502887
88Abnormal sex determination (HP:0012244)2.46061654
89Sex reversal (HP:0012245)2.46061654
90Glomerulonephritis (HP:0000099)2.45054993
91Mitral stenosis (HP:0001718)2.44426134
92Cerebral edema (HP:0002181)2.44326994
93Upper limb muscle weakness (HP:0003484)2.43503814
94Cholelithiasis (HP:0001081)2.43411339
95Abnormal gallbladder physiology (HP:0012438)2.43194070
96Cholecystitis (HP:0001082)2.43194070
97Recurrent gram-negative bacterial infections (HP:0005420)2.41698786
98Gout (HP:0001997)2.40725450
99Renal tubular dysfunction (HP:0000124)2.37701826
100Irritability (HP:0000737)2.36515338
101Abnormal protein glycosylation (HP:0012346)2.36295078
102Abnormal glycosylation (HP:0012345)2.36295078
103Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.36295078
104Abnormal protein N-linked glycosylation (HP:0012347)2.36295078
105Neonatal onset (HP:0003623)2.35437397
106Hand muscle atrophy (HP:0009130)2.34219533
107Neonatal death (HP:0003811)2.30047192
108Aplasia/Hypoplasia of the hallux (HP:0008362)2.29771055
109Increased serum pyruvate (HP:0003542)2.27858082
110Cardiovascular calcification (HP:0011915)2.27002738
111Hypoplasia of the uterus (HP:0000013)2.26075445
112Fatigue (HP:0012378)2.24271775
113CNS hypomyelination (HP:0003429)2.23953207
114Amyloidosis (HP:0011034)2.23337500
115Esophageal varix (HP:0002040)2.20714031
116Malnutrition (HP:0004395)2.20483946
117Round ear (HP:0100830)2.20069716
118Gingival bleeding (HP:0000225)2.18962313
119Insulin-resistant diabetes mellitus (HP:0000831)2.17720782
120Wrist flexion contracture (HP:0001239)2.17190562
121Anorexia (HP:0002039)2.17185239
122Abnormality of the renal cortex (HP:0011035)2.16332263
123Diaphragmatic weakness (HP:0009113)2.15289263
124Menorrhagia (HP:0000132)2.14438746
125Sensorimotor neuropathy (HP:0007141)2.13844790
126Brushfield spots (HP:0001088)2.13260710
127Pancreatitis (HP:0001733)2.12250767
128Enlarged kidneys (HP:0000105)2.10474877
129Late onset (HP:0003584)2.09703903
130Mixed hearing impairment (HP:0000410)2.08178538
131Aplasia/hypoplasia of the uterus (HP:0008684)2.07299969
132Thrombophlebitis (HP:0004418)2.06069738
133Patchy hypopigmentation of hair (HP:0011365)2.05797195
134Vomiting (HP:0002013)2.03886800
135Poikilocytosis (HP:0004447)2.03445969
136Abnormality of the gallbladder (HP:0005264)2.03400328
137Coxa valga (HP:0002673)2.02018324
138Postural tremor (HP:0002174)2.01684502
139J-shaped sella turcica (HP:0002680)2.01264100
140Opisthotonus (HP:0002179)2.00858796
141Hyperinsulinemic hypoglycemia (HP:0000825)2.00597959
142Generalized aminoaciduria (HP:0002909)2.00170612
143Conjunctival telangiectasia (HP:0000524)1.99888688
144Abnormality of urine glucose concentration (HP:0011016)1.99646514
145Glycosuria (HP:0003076)1.99646514
146Abnormality of the tricuspid valve (HP:0001702)1.99292381
147Hemorrhage of the eye (HP:0011885)1.97585422
148Atonic seizures (HP:0010819)1.96496927
149Azoospermia (HP:0000027)1.96087873
150Rickets (HP:0002748)1.92901555
151Hypergonadotropic hypogonadism (HP:0000815)1.91523738
152Respiratory distress (HP:0002098)1.89266976
153Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88877118
154Abnormality of iron homeostasis (HP:0011031)1.88358710
155Abnormal cartilage morphology (HP:0002763)1.88127155
156Hepatic necrosis (HP:0002605)1.86126594
157Hypophosphatemic rickets (HP:0004912)1.85748719
158Renal cortical cysts (HP:0000803)1.85654086
159Abnormality of transition element cation homeostasis (HP:0011030)1.85410383
160Stridor (HP:0010307)1.85270765
161Hyporeflexia of lower limbs (HP:0002600)1.85144193
162Intention tremor (HP:0002080)1.84693787
163Alkalosis (HP:0001948)1.82374379
164Poor suck (HP:0002033)1.81956877
165Abnormal tarsal ossification (HP:0008369)1.81836605
166Hydroxyprolinuria (HP:0003080)1.81680695
167Abnormality of proline metabolism (HP:0010907)1.81680695
168Abnormal enzyme/coenzyme activity (HP:0012379)1.81551767
169Elevated hepatic transaminases (HP:0002910)1.80988109
170Thickened helices (HP:0000391)1.80925087
171Abnormality of glycolysis (HP:0004366)1.80631898
172Fetal akinesia sequence (HP:0001989)1.80537131
173Status epilepticus (HP:0002133)1.80513755
174Attenuation of retinal blood vessels (HP:0007843)1.78917628
175Hyperglycemia (HP:0003074)1.78306718
176High pitched voice (HP:0001620)1.77503581
177Distal upper limb amyotrophy (HP:0007149)1.77292726
178Upper limb amyotrophy (HP:0009129)1.77292726
179Prominent supraorbital ridges (HP:0000336)1.75230973
180Abnormality of the vasculature of the conjunctiva (HP:0008054)1.74508531
181Abnormality of vitamin metabolism (HP:0100508)1.73758232
182Nephritis (HP:0000123)1.73697748
183Disproportionate short-trunk short stature (HP:0003521)1.71637531
184Abnormality of the vitreous humor (HP:0004327)1.70975337
185Clumsiness (HP:0002312)1.69461186
186Pulmonary embolism (HP:0002204)1.68137668

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B7.18135408
2BCKDK7.08247619
3SIK14.62055987
4FGFR44.55913766
5CDK84.52812027
6ERN14.26116594
7TGFBR13.86866173
8TAOK33.17062389
9INSRR3.13057747
10ERBB43.04010185
11MARK32.66748870
12CDK92.59799434
13TESK12.58868021
14MAP2K42.39511517
15PKN22.28332673
16PNCK2.19277302
17ACVR1B2.14792761
18MST1R2.14558926
19FLT31.96723280
20MAPK111.91960701
21OBSCN1.89541590
22PIK3CG1.79800483
23LATS11.70873254
24TYK21.68778291
25FGR1.67703676
26TRIB31.67244087
27PRKG21.55022638
28DAPK21.52332897
29ABL21.50143775
30PHKG21.49382803
31PHKG11.49382803
32LIMK11.47069544
33FRK1.45408527
34FGFR21.45007348
35PTK61.42955391
36NEK91.42000557
37ZAK1.41880227
38KDR1.27098769
39JAK21.24050256
40MAP3K71.22983256
41PRKAA21.15152880
42PINK11.11945787
43CDK31.11680406
44ADRBK21.06456314
45ERBB21.05641044
46GRK61.04367231
47TBK11.04243149
48JAK11.03937670
49MAP2K31.03289579
50MAP3K141.02024328
51MAPK41.01377722
52LMTK20.98621743
53NTRK20.96283767
54MAP3K100.94544913
55JAK30.94078132
56PRKCZ0.93414067
57MAPK150.92792950
58STK38L0.89008050
59MKNK20.88417182
60MET0.85182430
61MAP3K30.84319369
62MAPK120.82078181
63CDK60.80489179
64EPHB10.79901700
65CDK70.78594576
66PRKACG0.76763599
67EPHA30.76608857
68TIE10.75722201
69WNK40.75323786
70CAMK1D0.74497862
71RPS6KB10.73622408
72CAMK2G0.73621132
73FGFR10.72101124
74CSK0.72030432
75AKT20.71200050
76MAP3K110.70943879
77MAP2K60.68139970
78GSK3A0.67542924
79DYRK1B0.66447547
80SGK30.66133079
81PRKAA10.65902759
82IRAK30.62979031
83MAPK70.61608950
84RPS6KA50.61065394
85FGFR30.60641096
86RIPK10.58787690
87CSF1R0.56984202
88TGFBR20.55484804
89MYLK0.54934191
90IKBKE0.54827082
91PTK20.53157258
92TNK20.51670159
93PRKCQ0.51116110
94EPHA40.50626217
95PDGFRB0.50437296
96TLK10.50115467
97PDPK10.49877174
98SGK20.49842597
99CSNK1G10.49831293
100GRK10.47329616
101ADRBK10.47312857
102TAOK20.46552451
103ITK0.46043975
104CCNB10.46025632
105IGF1R0.45616938
106MAP3K50.45104959
107MAP3K130.43925319
108PKN10.43850870
109TAF10.43397249
110RET0.43217212
111MAP2K10.41501440
112PRKCG0.40843902
113CDK40.39518544
114WNK10.38645372
115MAP3K60.36639343
116ICK0.35538400
117EGFR0.35157523
118MUSK0.34570513
119MTOR0.34396080
120SGK2230.33915400
121SGK4940.33915400
122MELK0.32799629
123BMX0.32587474
124PBK0.32354856
125CAMK40.31733867
126PDK10.31561412
127CSNK1G20.29572814
128IRAK10.29406551
129IRAK20.29160734
130CSNK1A10.27641656
131MAP4K10.27392105
132NME10.26876361
133PIK3CA0.26718257
134DMPK0.26623744
135CAMK1G0.26616089
136LATS20.26278805
137CDK140.26268809
138PRKCA0.26199438
139MAP3K10.25350230
140CSNK1G30.25091798
141AKT30.23932309
142SGK10.23594908
143PLK40.22629145
144ABL10.22525530
145PDK40.22151562
146PDK30.22151562
147ROCK10.17920746
148CDK50.17592071
149CAMK10.17442810
150PRKG10.17368478
151PRKCE0.17270605
152RPS6KA10.17198045
153NTRK30.16019945
154MAP2K70.15613024
155CAMK2D0.15102464
156RPS6KB20.11832632
157EPHB20.11780772
158MKNK10.11609792
159CAMK2B0.10552454
160EIF2AK30.10322708
161AKT10.07742104
162STK380.07135013

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.55281649
2Nitrogen metabolism_Homo sapiens_hsa009103.63157682
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.44527967
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.37073389
5Arginine biosynthesis_Homo sapiens_hsa002203.09987286
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.80026858
7Complement and coagulation cascades_Homo sapiens_hsa046102.76901915
8Tryptophan metabolism_Homo sapiens_hsa003802.70042935
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.69157517
10Olfactory transduction_Homo sapiens_hsa047402.67958472
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.59984122
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.53794238
13Fatty acid degradation_Homo sapiens_hsa000712.47060047
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36482585
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26880953
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14131383
17Butanoate metabolism_Homo sapiens_hsa006502.13207064
18Peroxisome_Homo sapiens_hsa041462.07132112
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.95112880
20Chemical carcinogenesis_Homo sapiens_hsa052041.94984109
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.92871428
22Propanoate metabolism_Homo sapiens_hsa006401.91514729
23Histidine metabolism_Homo sapiens_hsa003401.90644700
24Taste transduction_Homo sapiens_hsa047421.90510942
25Mineral absorption_Homo sapiens_hsa049781.88585452
26PPAR signaling pathway_Homo sapiens_hsa033201.85862366
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.82744164
28Caffeine metabolism_Homo sapiens_hsa002321.79824339
29Fatty acid metabolism_Homo sapiens_hsa012121.79013732
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.78507924
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.76024877
32Staphylococcus aureus infection_Homo sapiens_hsa051501.75557985
33Retinol metabolism_Homo sapiens_hsa008301.72247407
34Hedgehog signaling pathway_Homo sapiens_hsa043401.71698246
35beta-Alanine metabolism_Homo sapiens_hsa004101.70460466
36GABAergic synapse_Homo sapiens_hsa047271.67886688
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67430323
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65458780
39Morphine addiction_Homo sapiens_hsa050321.64258562
40Selenocompound metabolism_Homo sapiens_hsa004501.58113628
41Phenylalanine metabolism_Homo sapiens_hsa003601.57830534
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56399089
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50004812
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49763825
45Bile secretion_Homo sapiens_hsa049761.49457341
46Tyrosine metabolism_Homo sapiens_hsa003501.44494902
47Circadian entrainment_Homo sapiens_hsa047131.41303050
48Pyruvate metabolism_Homo sapiens_hsa006201.36037108
49Sulfur metabolism_Homo sapiens_hsa009201.33060314
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.32574186
51Gap junction_Homo sapiens_hsa045401.31857919
52Fatty acid elongation_Homo sapiens_hsa000621.31461851
53Salivary secretion_Homo sapiens_hsa049701.30627127
54Starch and sucrose metabolism_Homo sapiens_hsa005001.30014927
55Renin secretion_Homo sapiens_hsa049241.27603895
56Phagosome_Homo sapiens_hsa041451.26021490
57Insulin secretion_Homo sapiens_hsa049111.24960115
58ABC transporters_Homo sapiens_hsa020101.21133351
59Biosynthesis of amino acids_Homo sapiens_hsa012301.21008564
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20876536
61Steroid biosynthesis_Homo sapiens_hsa001001.19765408
62Vibrio cholerae infection_Homo sapiens_hsa051101.18963521
63Folate biosynthesis_Homo sapiens_hsa007901.18599654
64Cocaine addiction_Homo sapiens_hsa050301.18063901
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16722153
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16509311
67Collecting duct acid secretion_Homo sapiens_hsa049661.15964719
68Fat digestion and absorption_Homo sapiens_hsa049751.14027522
69Carbon metabolism_Homo sapiens_hsa012001.11884191
70RNA degradation_Homo sapiens_hsa030181.09372505
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04206296
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02602209
73Maturity onset diabetes of the young_Homo sapiens_hsa049501.01410090
74Serotonergic synapse_Homo sapiens_hsa047260.98867929
75Other glycan degradation_Homo sapiens_hsa005110.97432051
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96716017
77Amphetamine addiction_Homo sapiens_hsa050310.96523544
78Gastric acid secretion_Homo sapiens_hsa049710.96345005
79Arginine and proline metabolism_Homo sapiens_hsa003300.95147280
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.95006915
81Vitamin B6 metabolism_Homo sapiens_hsa007500.94013278
82N-Glycan biosynthesis_Homo sapiens_hsa005100.92025593
83Sulfur relay system_Homo sapiens_hsa041220.90795440
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86781827
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84809011
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83862242
87Glutamatergic synapse_Homo sapiens_hsa047240.83578294
88Vitamin digestion and absorption_Homo sapiens_hsa049770.82697182
89Cholinergic synapse_Homo sapiens_hsa047250.81514160
90Lysine degradation_Homo sapiens_hsa003100.80978991
91Pancreatic secretion_Homo sapiens_hsa049720.80654144
92Purine metabolism_Homo sapiens_hsa002300.79081716
93Long-term potentiation_Homo sapiens_hsa047200.77649276
94Dopaminergic synapse_Homo sapiens_hsa047280.77550140
95One carbon pool by folate_Homo sapiens_hsa006700.75244494
96Calcium signaling pathway_Homo sapiens_hsa040200.75174100
97Nicotine addiction_Homo sapiens_hsa050330.74433533
98mRNA surveillance pathway_Homo sapiens_hsa030150.72137128
99Parkinsons disease_Homo sapiens_hsa050120.70715267
100Oxidative phosphorylation_Homo sapiens_hsa001900.70633606
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70142968
102Synaptic vesicle cycle_Homo sapiens_hsa047210.69947837
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67972819
104Glycerolipid metabolism_Homo sapiens_hsa005610.66334287
105Glutathione metabolism_Homo sapiens_hsa004800.63445842
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62387692
107Alcoholism_Homo sapiens_hsa050340.58070595
108Pentose phosphate pathway_Homo sapiens_hsa000300.56709838
109Legionellosis_Homo sapiens_hsa051340.54505950
110Fatty acid biosynthesis_Homo sapiens_hsa000610.54346145
111Dilated cardiomyopathy_Homo sapiens_hsa054140.53330929
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.50664978
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47085744
114TGF-beta signaling pathway_Homo sapiens_hsa043500.46771931
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46699958
116Metabolic pathways_Homo sapiens_hsa011000.45492634
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39490369
118Prion diseases_Homo sapiens_hsa050200.38179747
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24331087
120Galactose metabolism_Homo sapiens_hsa000520.24243404
121Insulin resistance_Homo sapiens_hsa049310.23474382
122Fructose and mannose metabolism_Homo sapiens_hsa000510.23433382
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.22175490
124Linoleic acid metabolism_Homo sapiens_hsa005910.21306578
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18043293
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.15392212
127Glucagon signaling pathway_Homo sapiens_hsa049220.10859961
128AMPK signaling pathway_Homo sapiens_hsa041520.02369642
129Ether lipid metabolism_Homo sapiens_hsa00565-0.2555508
130Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2389620
131Amoebiasis_Homo sapiens_hsa05146-0.2324603
132Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2302400
133Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2226324
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1973361
135Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1970144
136Renin-angiotensin system_Homo sapiens_hsa04614-0.1935943
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1929948
138Hepatitis C_Homo sapiens_hsa05160-0.1799802
139Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1731733
140Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1605736
141Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1533669
142African trypanosomiasis_Homo sapiens_hsa05143-0.1501609
143Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1335942
144Regulation of autophagy_Homo sapiens_hsa04140-0.1287156
145Insulin signaling pathway_Homo sapiens_hsa04910-0.0940985
146Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0872035
147Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0853265
148Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0670429
149Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0489219

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