UNC45B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)9.85496522
2actin-myosin filament sliding (GO:0033275)9.85496522
3sarcomere organization (GO:0045214)9.33094742
4cardiac myofibril assembly (GO:0055003)8.85163793
5myofibril assembly (GO:0030239)8.34390849
6actin-mediated cell contraction (GO:0070252)8.19612057
7negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.31943553
8regulation of skeletal muscle contraction (GO:0014819)7.17326018
9cardiac muscle contraction (GO:0060048)6.99137772
10cardiac muscle cell development (GO:0055013)6.60378536
11negative regulation of potassium ion transmembrane transport (GO:1901380)6.45257119
12actomyosin structure organization (GO:0031032)6.27692703
13cardiac muscle tissue morphogenesis (GO:0055008)6.25447787
14cardiac cell development (GO:0055006)6.21394501
15striated muscle contraction (GO:0006941)6.20521182
16regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.15191634
17positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.12195067
18actin filament-based movement (GO:0030048)6.11634074
19plasma membrane repair (GO:0001778)6.02722328
20regulation of relaxation of muscle (GO:1901077)6.00677608
21cardiac muscle hypertrophy (GO:0003300)5.89347677
22tricarboxylic acid cycle (GO:0006099)5.88693324
23heart process (GO:0003015)5.81680818
24heart contraction (GO:0060047)5.81680818
25sarcoplasmic reticulum calcium ion transport (GO:0070296)5.72066686
26muscle tissue morphogenesis (GO:0060415)5.70877566
27striated muscle hypertrophy (GO:0014897)5.65507743
28regulation of actin filament-based movement (GO:1903115)5.64691281
29ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.61827311
30regulation of sarcomere organization (GO:0060297)5.61221519
31adult heart development (GO:0007512)5.59836359
32regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.38038684
33carnitine shuttle (GO:0006853)5.24811801
34heart trabecula formation (GO:0060347)5.22048759
35regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.05182712
36regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.00971900
37muscle hypertrophy (GO:0014896)5.00844241
38skeletal muscle contraction (GO:0003009)4.98756241
39response to muscle activity (GO:0014850)4.93459479
40regulation of striated muscle contraction (GO:0006942)4.92225943
41ventricular cardiac muscle cell action potential (GO:0086005)4.91611960
42response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.91478392
43regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.82088763
44regulation of cell communication by electrical coupling (GO:0010649)4.75350294
45regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.69679874
46bundle of His cell to Purkinje myocyte communication (GO:0086069)4.69342685
47regulation of the force of heart contraction (GO:0002026)4.67467676
48regulation of acyl-CoA biosynthetic process (GO:0050812)4.55596105
49fatty acid transmembrane transport (GO:1902001)4.50396874
50negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.45830151
51cardiac chamber formation (GO:0003207)4.45608319
52mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.45165120
53cardiac muscle hypertrophy in response to stress (GO:0014898)4.33724944
54muscle hypertrophy in response to stress (GO:0003299)4.33724944
55cardiac muscle adaptation (GO:0014887)4.33724944
56oxidative phosphorylation (GO:0006119)4.23271022
57negative regulation of striated muscle cell apoptotic process (GO:0010664)4.19202556
58regulation of coenzyme metabolic process (GO:0051196)4.18155628
59regulation of cofactor metabolic process (GO:0051193)4.18155628
60striated muscle cell development (GO:0055002)4.17489205
61response to inactivity (GO:0014854)4.15910325
62regulation of cardioblast differentiation (GO:0051890)4.14819133
63muscle contraction (GO:0006936)4.14558265
64regulation of membrane repolarization (GO:0060306)4.13015912
65regulation of cardiac muscle cell contraction (GO:0086004)4.12299461
66ATP synthesis coupled proton transport (GO:0015986)4.12032503
67energy coupled proton transport, down electrochemical gradient (GO:0015985)4.12032503
68skeletal muscle fiber development (GO:0048741)4.11393910
69cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.04128375
70striated muscle adaptation (GO:0014888)4.01332813
71muscle cell fate commitment (GO:0042693)3.98365108
72myotube cell development (GO:0014904)3.97502355
73cardiac ventricle formation (GO:0003211)3.93370471
74striated muscle atrophy (GO:0014891)3.88392417
75relaxation of cardiac muscle (GO:0055119)3.87460370
76negative regulation of protein localization to cell surface (GO:2000009)3.87356691
77regulation of ATPase activity (GO:0043462)3.86036514
78regulation of ATP catabolic process (GO:1903289)3.86036514
79muscle cell cellular homeostasis (GO:0046716)3.86003709
80muscle system process (GO:0003012)3.85588063
81regulation of calcium ion transmembrane transport (GO:1903169)3.83674239
82regulation of calcium ion transmembrane transporter activity (GO:1901019)3.83674239
83skeletal muscle adaptation (GO:0043501)3.80730355
84carnitine transmembrane transport (GO:1902603)3.79782586
85skeletal muscle tissue development (GO:0007519)3.79473068
86ventricular cardiac muscle cell development (GO:0055015)3.74640693
87cell communication involved in cardiac conduction (GO:0086065)3.72346358
88respiratory electron transport chain (GO:0022904)3.71178646
89membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.70486584
90regulation of muscle system process (GO:0090257)3.66783130
91positive regulation of myotube differentiation (GO:0010831)3.66053937
92creatine metabolic process (GO:0006600)3.65927197
93regulation of heart rate (GO:0002027)3.62399173
94muscle cell development (GO:0055001)3.61113213
95electron transport chain (GO:0022900)3.60725859
96cardiac muscle cell action potential involved in contraction (GO:0086002)3.60530122
97positive regulation of myoblast differentiation (GO:0045663)3.59113929
98mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.57507049
99cardiac muscle cell action potential (GO:0086001)3.57056951
100regulation of muscle contraction (GO:0006937)3.54110961
101muscle fiber development (GO:0048747)3.52589455
102regulation of cardiac muscle contraction (GO:0055117)3.50424270
103negative regulation of potassium ion transport (GO:0043267)3.49064680
104response to caffeine (GO:0031000)3.45882242
105regulation of sulfur metabolic process (GO:0042762)3.45462628
106carnitine transport (GO:0015879)3.44949659
107amino-acid betaine transport (GO:0015838)3.44949659
108muscle atrophy (GO:0014889)3.44418792
109cell communication by electrical coupling (GO:0010644)3.42294504
110regulation of myoblast differentiation (GO:0045661)3.40683396
111relaxation of muscle (GO:0090075)3.40394713
112NADH metabolic process (GO:0006734)3.40020385
113muscle adaptation (GO:0043500)3.37200321
114regulation of striated muscle cell apoptotic process (GO:0010662)3.37183088
115negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.36292793
116negative regulation of calcium ion transmembrane transport (GO:1903170)3.36292793
117trabecula formation (GO:0060343)3.36266812
118pyrimidine ribonucleoside catabolic process (GO:0046133)3.34086266
119regulation of heart contraction (GO:0008016)3.32946323
120positive regulation of cation channel activity (GO:2001259)3.32920122
121regulation of skeletal muscle cell differentiation (GO:2001014)3.32011571
122positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.31059906
123regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.30612041
124cytidine metabolic process (GO:0046087)3.28890467
125cytidine catabolic process (GO:0006216)3.28890467
126cytidine deamination (GO:0009972)3.28890467
127skeletal muscle tissue regeneration (GO:0043403)3.28357390

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.21180315
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.80589994
3EP300_21415370_ChIP-Seq_HL-1_Mouse5.42216349
4EZH2_22144423_ChIP-Seq_EOC_Human4.78460538
5ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.60954513
6TBX20_22080862_ChIP-Seq_HEART_Mouse4.24054744
7TBX20_22328084_ChIP-Seq_HEART_Mouse4.24054744
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.04222484
9ESR1_20079471_ChIP-ChIP_T-47D_Human3.77425128
10* MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.57332839
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.54457886
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.18521855
13* GATA4_21415370_ChIP-Seq_HL-1_Mouse2.82001565
14ZNF263_19887448_ChIP-Seq_K562_Human2.79775072
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.74743388
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.49508485
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.43715576
18NKX2-5_21415370_ChIP-Seq_HL-1_Mouse2.23556417
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.21951937
20GATA1_22025678_ChIP-Seq_K562_Human2.05923797
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02912861
22CLOCK_20551151_ChIP-Seq_293T_Human1.93399816
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.83456388
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.83033837
25VDR_22108803_ChIP-Seq_LS180_Human1.73659045
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69404554
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.67435762
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.65911195
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.65375008
30BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.64861632
31PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.63568406
32GBX2_23144817_ChIP-Seq_PC3_Human1.56866242
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52447451
34ISL1_27105846_Chip-Seq_CPCs_Mouse1.49366025
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.45304795
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.45233007
37GATA2_21666600_ChIP-Seq_HMVEC_Human1.44265220
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.43735948
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.43012567
40PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.35290780
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34879601
42NFIB_24661679_ChIP-Seq_LUNG_Mouse1.32192496
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24914761
44* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24069693
45* EZH2_27294783_Chip-Seq_ESCs_Mouse1.24013047
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23598763
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22753301
48GATA1_19941826_ChIP-Seq_K562_Human1.20761499
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17698874
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17575256
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17517656
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17021552
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16916018
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.16897227
55SMAD4_21799915_ChIP-Seq_A2780_Human1.15238367
56PPARA_22158963_ChIP-Seq_LIVER_Mouse1.14666148
57ESR1_21235772_ChIP-Seq_MCF-7_Human1.14231540
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13607995
59* ELK3_25401928_ChIP-Seq_HUVEC_Human1.13090797
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12702013
61* EZH2_27304074_Chip-Seq_ESCs_Mouse1.12265046
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10694396
63CRX_20693478_ChIP-Seq_RETINA_Mouse1.09990736
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09793198
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.07495972
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06825037
67RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06825037
68LXR_22158963_ChIP-Seq_LIVER_Mouse1.06388558
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04711801
70DROSHA_22980978_ChIP-Seq_HELA_Human1.04568697
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04271471
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03128244
73NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03128244
74SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02749106
75SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02628995
76SMAD4_21741376_ChIP-Seq_HESCs_Human1.02201766
77* CTCF_27219007_Chip-Seq_Bcells_Human1.02057762
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.01818231
79MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01562909
80WT1_19549856_ChIP-ChIP_CCG9911_Human1.01226582
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01006809
82ZNF274_21170338_ChIP-Seq_K562_Hela1.00788250
83AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00763447
84SPI1_20517297_ChIP-Seq_HL60_Human1.00695847
85TP63_22573176_ChIP-Seq_HFKS_Human1.00465583
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00233768
87ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99318741
88SMC3_22415368_ChIP-Seq_MEFs_Mouse0.99168128
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98983657
90* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98874378
91CJUN_26792858_Chip-Seq_BT549_Human0.98050797
92* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96791134
93FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96230832
94LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95076358
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92156217
96WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91727576
97* KDM2B_26808549_Chip-Seq_DND41_Human0.91716432
98OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91715937
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90945836
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90832642
101RACK7_27058665_Chip-Seq_MCF-7_Human0.90798856
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90643875
103ATF3_27146783_Chip-Seq_COLON_Human0.88626246
104HTT_18923047_ChIP-ChIP_STHdh_Human0.88027202
105NFE2_27457419_Chip-Seq_LIVER_Mouse0.87565135
106* CBX2_27304074_Chip-Seq_ESCs_Mouse0.87545568
107TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86591823
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86495467
109ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86331922
110POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85950675
111FOXH1_21741376_ChIP-Seq_ESCs_Human0.85758157
112TBL1_22424771_ChIP-Seq_293T_Human0.85679918
113OCT4_20526341_ChIP-Seq_ESCs_Human0.84503187
114GF1_26923725_Chip-Seq_HPCs_Mouse0.84377611
115CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84105207
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83271054
117ZFP281_18757296_ChIP-ChIP_E14_Mouse0.83209245
118SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82366925
119JARID2_20075857_ChIP-Seq_MESCs_Mouse0.82187610
120FLI1_27457419_Chip-Seq_LIVER_Mouse0.81726587
121PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.81446399
122GATA2_19941826_ChIP-Seq_K562_Human0.81287447
123TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.80706156
124RNF2_27304074_Chip-Seq_ESCs_Mouse0.80255502
125SMAD3_21741376_ChIP-Seq_EPCs_Human0.78406443
126RUNX1_27514584_Chip-Seq_MCF-7_Human0.78225723
127YAP1_20516196_ChIP-Seq_MESCs_Mouse0.78203790
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.78036346
129* TCF4_23295773_ChIP-Seq_U87_Human0.77432921
130SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.77432036
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.77389464
132RARB_27405468_Chip-Seq_BRAIN_Mouse0.76782793
133TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76664920
134SMC1_22415368_ChIP-Seq_MEFs_Mouse0.75738468
135JARID2_20064375_ChIP-Seq_MESCs_Mouse0.75651296
136GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.75578281
137FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.73989911
138RXR_22158963_ChIP-Seq_LIVER_Mouse0.73378800
139UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.72553405
140CTCF_21964334_Chip-Seq_Bcells_Human0.71852250
141SOX9_24532713_ChIP-Seq_HFSC_Mouse0.71748224
142CTCF_21964334_ChIP-Seq_BJAB-B_Human0.70291439
143YY1_22570637_ChIP-Seq_MALME-3M_Human0.69551715
144BCL6_27268052_Chip-Seq_Bcells_Human0.69478429
145TP63_17297297_ChIP-ChIP_HaCaT_Human0.69365839
146SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.69168690
147SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.69046448
148P63_26484246_Chip-Seq_KERATINOCYTES_Human0.68893987
149GATA1_19941827_ChIP-Seq_MEL86_Mouse0.68768936
150SMAD3_21741376_ChIP-Seq_HESCs_Human0.68548886
151DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.68234358
152E2F1_20622854_ChIP-Seq_HELA_Human0.67244006
153TDRD3_21172665_ChIP-Seq_MCF-7_Human0.67119000
154GATA1_19941827_ChIP-Seq_MEL_Mouse0.66973150
155HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.66602375
156GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65861959
157CSB_26484114_Chip-Seq_FIBROBLAST_Human0.65037025
158NR3C1_23031785_ChIP-Seq_PC12_Mouse0.64971782

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle5.74483928
2MP0002837_dystrophic_cardiac_calcinosis5.65134246
3MP0003646_muscle_fatigue5.06556335
4MP0000751_myopathy5.05407263
5MP0000749_muscle_degeneration5.05300430
6MP0004036_abnormal_muscle_relaxation4.73624022
7MP0004215_abnormal_myocardial_fiber4.08064351
8MP0005330_cardiomyopathy3.76205659
9MP0004145_abnormal_muscle_electrophysio3.68695467
10MP0004087_abnormal_muscle_fiber3.33478226
11MP0002972_abnormal_cardiac_muscle3.15028323
12MP0005620_abnormal_muscle_contractility3.05100999
13MP0002106_abnormal_muscle_physiology3.00608261
14MP0008775_abnormal_heart_ventricle2.85754644
15MP0000750_abnormal_muscle_regeneration2.81945213
16MP0010630_abnormal_cardiac_muscle2.66553856
17MP0002269_muscular_atrophy2.60353861
18MP0001544_abnormal_cardiovascular_syste2.50731302
19MP0005385_cardiovascular_system_phenoty2.50731302
20MP0003137_abnormal_impulse_conducting2.49018506
21MP0000747_muscle_weakness2.48863215
22MP0005369_muscle_phenotype2.43298436
23MP0004130_abnormal_muscle_cell2.39653300
24MP0003828_pulmonary_edema2.37614455
25MP0000759_abnormal_skeletal_muscle2.36688437
26MP0006138_congestive_heart_failure2.32833975
27MP0004484_altered_response_of2.30351652
28MP0003221_abnormal_cardiomyocyte_apopto2.14269658
29MP0004085_abnormal_heartbeat1.95473158
30MP0004510_myositis1.94382449
31MP0002127_abnormal_cardiovascular_syste1.83498922
32MP0004233_abnormal_muscle_weight1.82861436
33MP0006036_abnormal_mitochondrial_physio1.79681500
34MP0003950_abnormal_plasma_membrane1.79478157
35MP0002332_abnormal_exercise_endurance1.63373883
36MP0003567_abnormal_fetal_cardiomyocyte1.58109729
37MP0010368_abnormal_lymphatic_system1.26280885
38MP0000266_abnormal_heart_morphology1.19931988
39MP0005666_abnormal_adipose_tissue1.14957783
40MP0000733_abnormal_muscle_development1.13798741
41MP0000343_altered_response_to1.07072579
42MP0004270_analgesia1.06288356
43MP0005451_abnormal_body_composition1.04024755
44MP0005670_abnormal_white_adipose1.03964185
45MP0006035_abnormal_mitochondrial_morpho1.03326290
46MP0002234_abnormal_pharynx_morphology1.02933773
47MP0001661_extended_life_span1.02668228
48MP0003279_aneurysm1.00508921
49MP0002108_abnormal_muscle_morphology0.99690737
50MP0001879_abnormal_lymphatic_vessel0.99180152
51MP0004272_abnormal_basement_membrane0.89275671
52MP0005266_abnormal_metabolism0.87507039
53MP0003806_abnormal_nucleotide_metabolis0.87439211
54MP0002128_abnormal_blood_circulation0.85527967
55MP0004185_abnormal_adipocyte_glucose0.81459424
56MP0003566_abnormal_cell_adhesion0.81431366
57MP0005165_increased_susceptibility_to0.80904659
58MP0000230_abnormal_systemic_arterial0.78391566
59MP0005375_adipose_tissue_phenotype0.73229956
60MP0000767_abnormal_smooth_muscle0.72841969
61MP0004147_increased_porphyrin_level0.71227211
62MP0005623_abnormal_meninges_morphology0.62742385
63MP0003705_abnormal_hypodermis_morpholog0.62692972
64MP0003045_fibrosis0.62279916
65MP0002925_abnormal_cardiovascular_devel0.61794291
66MP0002822_catalepsy0.58952395
67MP0002971_abnormal_brown_adipose0.57080661
68MP0002088_abnormal_embryonic_growth/wei0.54173270
69MP0003984_embryonic_growth_retardation0.54094501
70MP0001299_abnormal_eye_distance/0.51765395
71MP0003941_abnormal_skin_development0.50552485
72MP0000013_abnormal_adipose_tissue0.49699819
73MP0001784_abnormal_fluid_regulation0.48596480
74MP0001614_abnormal_blood_vessel0.47908977
75MP0005187_abnormal_penis_morphology0.40849192
76MP0003122_maternal_imprinting0.40584647
77MP0009780_abnormal_chondrocyte_physiolo0.40313799
78MP0005319_abnormal_enzyme/_coenzyme0.39655858
79MP0003948_abnormal_gas_homeostasis0.38043998
80MP0005595_abnormal_vascular_smooth0.36727508
81MP0000372_irregular_coat_pigmentation0.36535310
82MP0000003_abnormal_adipose_tissue0.34779473
83MP0004043_abnormal_pH_regulation0.34568445
84MP0009384_cardiac_valve_regurgitation0.34221500
85MP0002078_abnormal_glucose_homeostasis0.33499925
86MP0005275_abnormal_skin_tensile0.33370918
87MP0005167_abnormal_blood-brain_barrier0.32280782
88MP0005380_embryogenesis_phenotype0.31486613
89MP0001672_abnormal_embryogenesis/_devel0.31486613
90MP0008438_abnormal_cutaneous_collagen0.30496371
91MP0008569_lethality_at_weaning0.30334446
92MP0002638_abnormal_pupillary_reflex0.28518842
93MP0008961_abnormal_basal_metabolism0.27017245
94MP0000249_abnormal_blood_vessel0.26858008
95MP0004134_abnormal_chest_morphology0.26124948
96MP0009250_abnormal_appendicular_skeleto0.25667437
97MP0001727_abnormal_embryo_implantation0.25572724
98MP0002249_abnormal_larynx_morphology0.23594022
99MP0003385_abnormal_body_wall0.23583871
100MP0000762_abnormal_tongue_morphology0.23507407
101MP0010030_abnormal_orbit_morphology0.22994175
102MP0005376_homeostasis/metabolism_phenot0.22742534
103MP0002114_abnormal_axial_skeleton0.22595936
104MP0002102_abnormal_ear_morphology0.20892782
105MP0005503_abnormal_tendon_morphology0.20722929
106MP0006276_abnormal_autonomic_nervous0.20230783
107MP0005334_abnormal_fat_pad0.20215036
108MP0005584_abnormal_enzyme/coenzyme_acti0.19367981
109MP0001984_abnormal_olfaction0.18508625
110MP0002133_abnormal_respiratory_system0.18227063
111MP0005388_respiratory_system_phenotype0.18227063
112MP0009672_abnormal_birth_weight0.17298818
113MP0002896_abnormal_bone_mineralization0.16693058
114MP0001943_abnormal_respiration0.16351300
115MP0005386_behavior/neurological_phenoty0.16301857
116MP0004924_abnormal_behavior0.16301857
117MP0004142_abnormal_muscle_tone0.15883099
118MP0001175_abnormal_lung_morphology0.15820324
119MP0009697_abnormal_copulation0.15690144
120MP0005452_abnormal_adipose_tissue0.15399661
121MP0001958_emphysema0.15226174
122MP0009115_abnormal_fat_cell0.15179454
123MP0002909_abnormal_adrenal_gland0.15171401
124MP0000534_abnormal_ureter_morphology0.14889434

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)7.37337345
2Sudden death (HP:0001699)7.23747188
3Exercise-induced myalgia (HP:0003738)7.18430041
4Calf muscle hypertrophy (HP:0008981)6.85037535
5Muscle hypertrophy of the lower extremities (HP:0008968)6.61745668
6Ventricular tachycardia (HP:0004756)5.91715511
7Muscle fiber splitting (HP:0003555)5.61454911
8Subaortic stenosis (HP:0001682)5.58666743
9Abnormality of the left ventricular outflow tract (HP:0011103)5.58666743
10Abnormality of the calf musculature (HP:0001430)5.41828235
11Hyporeflexia of lower limbs (HP:0002600)5.20254106
12Myoglobinuria (HP:0002913)5.19250286
13Atrial fibrillation (HP:0005110)5.13142305
14Muscle fiber inclusion bodies (HP:0100299)4.99504980
15Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.94511288
16Lipoatrophy (HP:0100578)4.90621821
17Primary atrial arrhythmia (HP:0001692)4.77793458
18EMG: myopathic abnormalities (HP:0003458)4.75396210
19Type 1 muscle fiber predominance (HP:0003803)4.67946167
20Supraventricular tachycardia (HP:0004755)4.62201457
21Supraventricular arrhythmia (HP:0005115)4.53910150
22Nemaline bodies (HP:0003798)4.39080558
23Rhabdomyolysis (HP:0003201)4.24713344
24Right ventricular cardiomyopathy (HP:0011663)4.10889398
25Increased connective tissue (HP:0009025)4.07450428
26Dilated cardiomyopathy (HP:0001644)4.06865188
27Asymmetric septal hypertrophy (HP:0001670)4.06172283
28Difficulty running (HP:0009046)3.95341035
29Syncope (HP:0001279)3.77325636
30Palpitations (HP:0001962)3.74880027
31Prolonged QT interval (HP:0001657)3.67519813
32Myotonia (HP:0002486)3.65002245
33Ventricular arrhythmia (HP:0004308)3.61903572
34Bundle branch block (HP:0011710)3.50146186
35Muscle stiffness (HP:0003552)3.30804887
36Malignant hyperthermia (HP:0002047)3.29341499
37Distal arthrogryposis (HP:0005684)3.20291139
38Neck muscle weakness (HP:0000467)3.20064822
39Fetal akinesia sequence (HP:0001989)3.16124461
40Difficulty climbing stairs (HP:0003551)3.09925820
41Heart block (HP:0012722)3.08185226
42Atrioventricular block (HP:0001678)2.94349155
43Distal lower limb muscle weakness (HP:0009053)2.93362256
44Abnormal atrioventricular conduction (HP:0005150)2.90547145
45Popliteal pterygium (HP:0009756)2.87920416
46Ventricular fibrillation (HP:0001663)2.86473180
47Areflexia of lower limbs (HP:0002522)2.85221070
48Round ear (HP:0100830)2.82720562
49Abnormal finger flexion creases (HP:0006143)2.82002975
50Myopathic facies (HP:0002058)2.80550337
51Abnormality of skeletal muscle fiber size (HP:0012084)2.78369164
52Centrally nucleated skeletal muscle fibers (HP:0003687)2.72797125
53Rimmed vacuoles (HP:0003805)2.71949300
54Abnormal EKG (HP:0003115)2.69578010
55Increased variability in muscle fiber diameter (HP:0003557)2.68467496
56Left ventricular hypertrophy (HP:0001712)2.63862910
57Hip contracture (HP:0003273)2.63484819
58Abnormal mitochondria in muscle tissue (HP:0008316)2.60627216
59Generalized muscle weakness (HP:0003324)2.58782879
60Weak cry (HP:0001612)2.58194809
61Acute necrotizing encephalopathy (HP:0006965)2.54725731
62Ragged-red muscle fibers (HP:0003200)2.53024613
63Bulbar palsy (HP:0001283)2.51282095
64EMG: neuropathic changes (HP:0003445)2.49838096
65Hepatic necrosis (HP:0002605)2.43848300
66Ulnar deviation of the wrist (HP:0003049)2.43094825
67Mildly elevated creatine phosphokinase (HP:0008180)2.42627277
68Palmoplantar keratoderma (HP:0000982)2.36656672
69Type 2 muscle fiber atrophy (HP:0003554)2.33952609
70Aplasia of the musculature (HP:0100854)2.31709995
71Exercise intolerance (HP:0003546)2.30667998
72Abnormality of the calcaneus (HP:0008364)2.20569602
73Congenital malformation of the right heart (HP:0011723)2.20402118
74Double outlet right ventricle (HP:0001719)2.20402118
75Conjunctival hamartoma (HP:0100780)2.20151989
76Muscular dystrophy (HP:0003560)2.14887968
77Acute encephalopathy (HP:0006846)2.14383595
78Gowers sign (HP:0003391)2.12148740
79Limb-girdle muscle atrophy (HP:0003797)2.10535414
80Ketoacidosis (HP:0001993)2.10527817
81Hypoglycemic coma (HP:0001325)2.10227191
82Muscle fiber atrophy (HP:0100295)2.09323137
83Progressive macrocephaly (HP:0004481)2.08305271
84Hepatocellular necrosis (HP:0001404)2.07743547
85Hypoplastic heart (HP:0001961)2.04976383
86Abnormality of the foot musculature (HP:0001436)2.04314856
87Mitochondrial inheritance (HP:0001427)2.03284396
88Increased muscle lipid content (HP:0009058)2.02432820
89Abnormality of placental membranes (HP:0011409)1.98448314
90Amniotic constriction ring (HP:0009775)1.98448314
91Facial diplegia (HP:0001349)1.98411966
92Calcaneovalgus deformity (HP:0001848)1.97878800
93Increased CSF lactate (HP:0002490)1.97495839
94Hypoplastic ischia (HP:0003175)1.92642037
95Respiratory insufficiency due to muscle weakness (HP:0002747)1.92084720
96Scapular winging (HP:0003691)1.91284326
97Abnormality of the shoulder girdle musculature (HP:0001435)1.91238780
98Dicarboxylic aciduria (HP:0003215)1.90535838
99Abnormality of dicarboxylic acid metabolism (HP:0010995)1.90535838
100Waddling gait (HP:0002515)1.88450626
101Progressive muscle weakness (HP:0003323)1.87220301
102Cerebral edema (HP:0002181)1.86536381
103Limited hip movement (HP:0008800)1.85372925
104Congestive heart failure (HP:0001635)1.84750197
105Foot dorsiflexor weakness (HP:0009027)1.82325422
106Steppage gait (HP:0003376)1.80955704
107Metatarsus adductus (HP:0001840)1.80841932
108Hypoplastic left heart (HP:0004383)1.80652996
109Increased intramyocellular lipid droplets (HP:0012240)1.80350847
110Proximal amyotrophy (HP:0007126)1.80087755
111Distal lower limb amyotrophy (HP:0008944)1.79921006
112Abnormality of fatty-acid metabolism (HP:0004359)1.79872924
113Frequent falls (HP:0002359)1.78937448
114Pheochromocytoma (HP:0002666)1.78701773
115Deformed tarsal bones (HP:0008119)1.77323079
116Spinal rigidity (HP:0003306)1.77188484
117Neoplasm of the adrenal gland (HP:0100631)1.76874993
118Fatigable weakness (HP:0003473)1.76244410
119Abnormality of the neuromuscular junction (HP:0003398)1.76244410
120Lactic acidosis (HP:0003128)1.75983322
121Absent phalangeal crease (HP:0006109)1.74837494
122Slender build (HP:0001533)1.74816607
123Hyperkalemia (HP:0002153)1.73038776
124Lower limb amyotrophy (HP:0007210)1.60368081
125Nonprogressive disorder (HP:0003680)1.56038499
126Easy fatigability (HP:0003388)1.55756608

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.36988318
2TTN5.22548629
3PHKG13.94710328
4PHKG23.94710328
5MYLK3.88492594
6PKN22.85327604
7DMPK2.81411403
8PDK32.80477016
9PDK42.80477016
10TIE12.80175503
11STK242.76566368
12PIK3CA2.46863766
13MUSK2.41953061
14LMTK22.26987845
15TRIB32.22345767
16NEK12.20606462
17BCKDK2.01808106
18PDK21.82287190
19MAP2K31.78940377
20ZAK1.77082897
21PINK11.67175012
22STK38L1.51219618
23ILK1.40981274
24MAPK121.27030557
25MARK11.25585983
26MAP3K71.25328796
27NME11.13418929
28PIK3CG1.12070680
29TRPM71.10359382
30CDC42BPA1.04635375
31KDR1.01045463
32CCNB10.98491527
33PRKD10.97993558
34ROCK10.88215969
35EEF2K0.86408304
36FLT30.85634427
37CAMK2D0.84868176
38PRKAA20.83844986
39PAK30.83833683
40RIPK10.83097638
41INSRR0.81268786
42PRKAA10.80685485
43MAP3K50.79870571
44TGFBR20.79382037
45MAP3K30.77836700
46MOS0.76636730
47DAPK30.74617208
48MAPKAPK30.74286909
49STK40.73671421
50PTK2B0.67785588
51GRK70.66319647
52WNK40.60387632
53MAP2K60.58754470
54MAPK40.58283644
55ERBB30.57481714
56LIMK10.53592715
57CAMK10.53162595
58MAP2K10.52190203
59DYRK1B0.50818396
60AKT20.48411086
61MAP2K40.48052376
62CAMK40.48042542
63PKN10.47026169
64EPHA30.45691397
65PRKACB0.44974924
66KSR20.44873224
67TGFBR10.44595423
68NEK90.44351029
69CAMK2B0.43439518
70ROCK20.40785161
71RPS6KL10.39886743
72RPS6KC10.39886743
73PRKD30.37142522
74MAP3K100.36363023
75CAMK2A0.35371192
76STK380.34763211
77LATS10.34241334
78DDR20.33709125
79RPS6KA60.32874995
80PTK60.32809940
81CAMK2G0.32793042
82SGK30.32706519
83WNK10.31501227
84PDGFRA0.31185999
85PRKG20.30543593
86PRKACA0.29719119
87STK30.29315143
88EPHB20.29160366
89SGK20.28073791
90PRKG10.27124673
91MARK30.27080079
92NME20.26426986
93LATS20.25923247
94MAP3K130.24455116
95MAPK100.23885126
96RPS6KB20.22651878
97FER0.22357066
98NLK0.21577743
99EPHB10.21402554
100PRKACG0.20984237
101STK390.20269799
102SIK10.20265783
103PDK10.20205942
104MAPK110.19933791
105PRKCE0.19400133
106MARK20.19239270
107MAPK70.19084699
108PDPK10.18754461
109LRRK20.18358243
110PAK20.18083282
111MAP3K110.17493622
112RAF10.17300878
113RPS6KB10.16889935
114STK110.16114336
115RPS6KA10.14873816
116SGK10.14702610
117RET0.11898633
118PRKCH0.11615681
119MTOR0.11397122
120KSR10.10932632
121UHMK10.09601228
122SGK2230.09417426
123RPS6KA30.09074974
124ICK0.08884677
125FGFR10.07529191
126MAP3K60.07221953
127RPS6KA20.06429658

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.89424716
2Cardiac muscle contraction_Homo sapiens_hsa042604.94704186
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.30237889
4Dilated cardiomyopathy_Homo sapiens_hsa054144.12126505
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.08611362
6Parkinsons disease_Homo sapiens_hsa050123.26826651
7Oxidative phosphorylation_Homo sapiens_hsa001903.01696639
8Propanoate metabolism_Homo sapiens_hsa006402.88807368
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.80740043
10Carbon metabolism_Homo sapiens_hsa012002.53857246
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.51502607
12Fatty acid degradation_Homo sapiens_hsa000712.40187535
13Alzheimers disease_Homo sapiens_hsa050102.35792288
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.17364121
15Huntingtons disease_Homo sapiens_hsa050162.04605316
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.98678253
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93285268
18Fatty acid metabolism_Homo sapiens_hsa012121.77799837
19Pyruvate metabolism_Homo sapiens_hsa006201.70323477
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.70013529
21Viral myocarditis_Homo sapiens_hsa054161.64553947
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46600902
23Biosynthesis of amino acids_Homo sapiens_hsa012301.41155313
24Starch and sucrose metabolism_Homo sapiens_hsa005001.34442218
25Glucagon signaling pathway_Homo sapiens_hsa049221.34168969
26Insulin resistance_Homo sapiens_hsa049311.20909998
27cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18622858
28Galactose metabolism_Homo sapiens_hsa000521.05450646
29Insulin signaling pathway_Homo sapiens_hsa049101.03248811
30HIF-1 signaling pathway_Homo sapiens_hsa040661.00303085
31Adipocytokine signaling pathway_Homo sapiens_hsa049200.99384184
32Fatty acid elongation_Homo sapiens_hsa000620.99170588
33Tight junction_Homo sapiens_hsa045300.98315442
34Focal adhesion_Homo sapiens_hsa045100.95176924
35Oxytocin signaling pathway_Homo sapiens_hsa049210.88494024
36Butanoate metabolism_Homo sapiens_hsa006500.88324868
37Calcium signaling pathway_Homo sapiens_hsa040200.84967167
38Fructose and mannose metabolism_Homo sapiens_hsa000510.82364255
39PPAR signaling pathway_Homo sapiens_hsa033200.82218074
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81538634
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81106595
42Vascular smooth muscle contraction_Homo sapiens_hsa042700.79089558
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77983190
44AMPK signaling pathway_Homo sapiens_hsa041520.77898007
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76067661
46Central carbon metabolism in cancer_Homo sapiens_hsa052300.74439908
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73885223
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67649047
49Circadian rhythm_Homo sapiens_hsa047100.63344417
50Arginine and proline metabolism_Homo sapiens_hsa003300.59811696
51Adherens junction_Homo sapiens_hsa045200.56319614
52Salivary secretion_Homo sapiens_hsa049700.56280887
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.50266993
54Lysine degradation_Homo sapiens_hsa003100.50182683
55Long-term potentiation_Homo sapiens_hsa047200.49603217
56Arginine biosynthesis_Homo sapiens_hsa002200.48254271
57beta-Alanine metabolism_Homo sapiens_hsa004100.47413914
58Tryptophan metabolism_Homo sapiens_hsa003800.47017003
59ECM-receptor interaction_Homo sapiens_hsa045120.45270386
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44088335
61Protein digestion and absorption_Homo sapiens_hsa049740.42709896
62Cholinergic synapse_Homo sapiens_hsa047250.42366583
63Phenylalanine metabolism_Homo sapiens_hsa003600.40156822
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38481138
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37948835
66Nitrogen metabolism_Homo sapiens_hsa009100.37471153
67Amphetamine addiction_Homo sapiens_hsa050310.36981757
68Peroxisome_Homo sapiens_hsa041460.36207507
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35099086
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33995721
71Renin secretion_Homo sapiens_hsa049240.33299366
72Type II diabetes mellitus_Homo sapiens_hsa049300.33098498
73Fatty acid biosynthesis_Homo sapiens_hsa000610.32360979
74Proteoglycans in cancer_Homo sapiens_hsa052050.30502409
75Pentose phosphate pathway_Homo sapiens_hsa000300.30335768
76Regulation of autophagy_Homo sapiens_hsa041400.29283420
77Platelet activation_Homo sapiens_hsa046110.28900437
78Amoebiasis_Homo sapiens_hsa051460.27481856
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27220025
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26468774
81Metabolic pathways_Homo sapiens_hsa011000.26358059
82Gastric acid secretion_Homo sapiens_hsa049710.24660374
83cAMP signaling pathway_Homo sapiens_hsa040240.24270791
84FoxO signaling pathway_Homo sapiens_hsa040680.21787900
85Insulin secretion_Homo sapiens_hsa049110.21635443
86Olfactory transduction_Homo sapiens_hsa047400.19712001
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19284321
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.16598643
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.14786898
90Tyrosine metabolism_Homo sapiens_hsa003500.14391204
91GABAergic synapse_Homo sapiens_hsa047270.14020682
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.13831547
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.13282231
94Endometrial cancer_Homo sapiens_hsa052130.13151477
95Long-term depression_Homo sapiens_hsa047300.12251393
96Dopaminergic synapse_Homo sapiens_hsa047280.10932899
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.10738504
98GnRH signaling pathway_Homo sapiens_hsa049120.10639804
99Ovarian steroidogenesis_Homo sapiens_hsa049130.10496062
100mTOR signaling pathway_Homo sapiens_hsa041500.10410664
101Circadian entrainment_Homo sapiens_hsa047130.10188078
102Renal cell carcinoma_Homo sapiens_hsa052110.09928423
103VEGF signaling pathway_Homo sapiens_hsa043700.07761573
104Thyroid hormone synthesis_Homo sapiens_hsa049180.07733411
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.05096642
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.03695152
107Fat digestion and absorption_Homo sapiens_hsa049750.02348279
108Small cell lung cancer_Homo sapiens_hsa052220.02139393
109MAPK signaling pathway_Homo sapiens_hsa040100.01963868
110Notch signaling pathway_Homo sapiens_hsa043300.01649841
111Toxoplasmosis_Homo sapiens_hsa051450.00977014
112Rap1 signaling pathway_Homo sapiens_hsa04015-0.0543188
113Gap junction_Homo sapiens_hsa04540-0.0459616
114Pathways in cancer_Homo sapiens_hsa05200-0.0423132
115Pancreatic secretion_Homo sapiens_hsa04972-0.0368632
116Hippo signaling pathway_Homo sapiens_hsa04390-0.0351470
117Purine metabolism_Homo sapiens_hsa00230-0.0099440
118Bile secretion_Homo sapiens_hsa04976-0.0076683
119Melanogenesis_Homo sapiens_hsa04916-0.0037772

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