UMPS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.48492222
2DNA strand elongation (GO:0022616)5.22491407
3DNA replication initiation (GO:0006270)5.15880526
4DNA unwinding involved in DNA replication (GO:0006268)5.15214010
5telomere maintenance via semi-conservative replication (GO:0032201)5.09552191
6IMP biosynthetic process (GO:0006188)4.67577765
7purine nucleobase biosynthetic process (GO:0009113)4.64416953
8* nucleobase biosynthetic process (GO:0046112)4.63870289
9DNA replication checkpoint (GO:0000076)4.59784318
10telomere maintenance via recombination (GO:0000722)4.49870659
11folic acid-containing compound biosynthetic process (GO:0009396)4.47236735
12ribosomal small subunit assembly (GO:0000028)4.47028469
13formation of translation preinitiation complex (GO:0001731)4.27886205
14mitotic recombination (GO:0006312)4.24698691
15protein localization to kinetochore (GO:0034501)4.20026496
16maturation of SSU-rRNA (GO:0030490)4.14654034
17IMP metabolic process (GO:0046040)4.11965278
18telomere maintenance via telomere lengthening (GO:0010833)4.06226523
19DNA deamination (GO:0045006)3.97945644
20mitotic metaphase plate congression (GO:0007080)3.94591056
21CENP-A containing nucleosome assembly (GO:0034080)3.90444161
22DNA replication-dependent nucleosome organization (GO:0034723)3.89866510
23DNA replication-dependent nucleosome assembly (GO:0006335)3.89866510
24mitotic nuclear envelope disassembly (GO:0007077)3.88054294
25chromatin remodeling at centromere (GO:0031055)3.86111836
26nucleotide-excision repair, DNA gap filling (GO:0006297)3.81181338
27DNA catabolic process, exonucleolytic (GO:0000738)3.79796038
28ribosome biogenesis (GO:0042254)3.77782327
29regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.69200485
30DNA double-strand break processing (GO:0000729)3.64198048
31negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.63194687
32negative regulation of ligase activity (GO:0051352)3.63194687
33maturation of 5.8S rRNA (GO:0000460)3.61278261
34nuclear pore organization (GO:0006999)3.61251810
35ribosome assembly (GO:0042255)3.58135309
36nuclear envelope disassembly (GO:0051081)3.56608091
37membrane disassembly (GO:0030397)3.56608091
38DNA replication-independent nucleosome organization (GO:0034724)3.56504811
39DNA replication-independent nucleosome assembly (GO:0006336)3.56504811
40ribonucleoprotein complex biogenesis (GO:0022613)3.54748717
41ribosomal large subunit biogenesis (GO:0042273)3.54523699
42viral transcription (GO:0019083)3.52095344
43regulation of mitochondrial translation (GO:0070129)3.50521649
44translational termination (GO:0006415)3.50230607
45protein localization to chromosome, centromeric region (GO:0071459)3.47299161
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.46820597
47regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.46531845
48regulation of mitotic spindle checkpoint (GO:1903504)3.46531845
49metaphase plate congression (GO:0051310)3.46114046
50nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.40813087
51folic acid metabolic process (GO:0046655)3.40476482
52termination of RNA polymerase III transcription (GO:0006386)3.40287583
53transcription elongation from RNA polymerase III promoter (GO:0006385)3.40287583
54establishment of protein localization to mitochondrial membrane (GO:0090151)3.38321341
55nuclear pore complex assembly (GO:0051292)3.35609287
56replication fork processing (GO:0031297)3.35398907
57DNA damage response, detection of DNA damage (GO:0042769)3.34973777
58translational elongation (GO:0006414)3.34466891
59mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.33699031
60rRNA processing (GO:0006364)3.31237071
61DNA duplex unwinding (GO:0032508)3.30594211
62pseudouridine synthesis (GO:0001522)3.30484732
63signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.30304244
64signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.30304244
65signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.30304244
66translational initiation (GO:0006413)3.30006179
67DNA geometric change (GO:0032392)3.28877373
68spliceosomal snRNP assembly (GO:0000387)3.27380956
69DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.26945789
70chaperone-mediated protein transport (GO:0072321)3.26935977
71signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.25637561
72intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.25637561
73mitochondrial RNA metabolic process (GO:0000959)3.24938653
74signal transduction involved in DNA integrity checkpoint (GO:0072401)3.24053401
75signal transduction involved in DNA damage checkpoint (GO:0072422)3.24053401
76meiotic chromosome segregation (GO:0045132)3.22906874
77somatic hypermutation of immunoglobulin genes (GO:0016446)3.22069056
78somatic diversification of immune receptors via somatic mutation (GO:0002566)3.22069056
79histone exchange (GO:0043486)3.21758550
80signal transduction involved in cell cycle checkpoint (GO:0072395)3.21622838
81rRNA metabolic process (GO:0016072)3.19811511
82regulation of translational termination (GO:0006449)3.19481328
83peptidyl-histidine modification (GO:0018202)3.18888389
84kinetochore organization (GO:0051383)3.18682449
85SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.17864191
86regulation of cellular amino acid metabolic process (GO:0006521)3.17260551
87protein K6-linked ubiquitination (GO:0085020)3.16851467
88telomere maintenance (GO:0000723)3.16405846
89telomere organization (GO:0032200)3.16010298
90cullin deneddylation (GO:0010388)3.14833797
91ribosomal small subunit biogenesis (GO:0042274)3.14447598
92establishment of chromosome localization (GO:0051303)3.14428405
93deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.14253781
94G1/S transition of mitotic cell cycle (GO:0000082)3.13105726
95cell cycle G1/S phase transition (GO:0044843)3.13105726
96mitotic chromosome condensation (GO:0007076)3.12235049
97transcription-coupled nucleotide-excision repair (GO:0006283)3.11340688
98positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.08786776
99cotranslational protein targeting to membrane (GO:0006613)3.07767732
100protein targeting to ER (GO:0045047)3.06623300
101regulation of nuclear cell cycle DNA replication (GO:0033262)3.04691245
102mitotic sister chromatid segregation (GO:0000070)3.04681405
103double-strand break repair via nonhomologous end joining (GO:0006303)3.04289481
104non-recombinational repair (GO:0000726)3.04289481
105attachment of spindle microtubules to kinetochore (GO:0008608)3.03562610
106rRNA methylation (GO:0031167)3.03025914
107ATP synthesis coupled proton transport (GO:0015986)3.02759913
108energy coupled proton transport, down electrochemical gradient (GO:0015985)3.02759913
109histone mRNA metabolic process (GO:0008334)3.02720582
110nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02367319
111establishment of integrated proviral latency (GO:0075713)3.02237802
112pteridine-containing compound biosynthetic process (GO:0042559)3.01963942
113protein deneddylation (GO:0000338)3.00593935
114tetrahydrofolate metabolic process (GO:0046653)3.00214305
1157-methylguanosine mRNA capping (GO:0006370)3.00131530
116regulation of spindle organization (GO:0090224)2.99414438
117regulation of centriole replication (GO:0046599)2.98229074
118negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.96171030
119positive regulation of ligase activity (GO:0051351)2.95838045
120regulation of double-strand break repair via homologous recombination (GO:0010569)2.95814879
121maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.95579997
122termination of RNA polymerase II transcription (GO:0006369)2.95473803
123anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.95379144
124L-serine metabolic process (GO:0006563)2.93197373
125regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.91797756
126RNA capping (GO:0036260)2.91442302
1277-methylguanosine RNA capping (GO:0009452)2.91442302
128rRNA modification (GO:0000154)2.90355673
129establishment of protein localization to endoplasmic reticulum (GO:0072599)2.89185999
130protein localization to endoplasmic reticulum (GO:0070972)2.88792179
131translesion synthesis (GO:0019985)2.88200826
132proteasome assembly (GO:0043248)2.87955280
133postreplication repair (GO:0006301)2.87301438
134mismatch repair (GO:0006298)2.84548069
135positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83408421
136kinetochore assembly (GO:0051382)2.83257589
137DNA replication (GO:0006260)2.83147154
138deoxyribonucleotide biosynthetic process (GO:0009263)2.83031196
139negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.82757703
140chromatin assembly or disassembly (GO:0006333)2.81963445
141spliceosomal complex assembly (GO:0000245)2.80256309
142sister chromatid segregation (GO:0000819)2.79431895
143viral mRNA export from host cell nucleus (GO:0046784)2.79403901
144translation (GO:0006412)2.77981236
145DNA conformation change (GO:0071103)2.76646827
146RNA splicing, via transesterification reactions (GO:0000375)2.76486844
147base-excision repair (GO:0006284)2.76252888
148RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.76181529
149mRNA splicing, via spliceosome (GO:0000398)2.76181529

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.23064628
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.27612639
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.85597476
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.60389754
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.57761021
6* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.19304488
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.96733636
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.92012270
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87046801
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84840678
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81213528
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.76560786
13* GABP_17652178_ChIP-ChIP_JURKAT_Human2.73590487
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.69374710
15* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48989293
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.40352950
17* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32963096
18XRN2_22483619_ChIP-Seq_HELA_Human2.29349142
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19869777
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17158416
21VDR_23849224_ChIP-Seq_CD4+_Human2.16041299
22AR_21909140_ChIP-Seq_LNCAP_Human2.11714089
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11335476
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.03411280
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02135340
26FOXP3_21729870_ChIP-Seq_TREG_Human1.98576656
27DCP1A_22483619_ChIP-Seq_HELA_Human1.95305855
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85551636
29GABP_19822575_ChIP-Seq_HepG2_Human1.84676142
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84350757
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84291035
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.83731908
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82543844
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81539936
35* TTF2_22483619_ChIP-Seq_HELA_Human1.72033427
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71699815
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70874438
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.70714460
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69016142
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.66089952
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65187779
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59920630
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59623473
44CIITA_25753668_ChIP-Seq_RAJI_Human1.59446206
45* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.59431731
46MYC_22102868_ChIP-Seq_BL_Human1.59419977
47* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56881254
48* ELK1_19687146_ChIP-ChIP_HELA_Human1.55732764
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50842364
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50619836
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.49289788
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.47002454
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.43831565
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42576891
55KDM5A_27292631_Chip-Seq_BREAST_Human1.41305779
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37367329
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36218585
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36192103
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34330004
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30637676
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29518593
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29176251
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23996241
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23390058
65EWS_26573619_Chip-Seq_HEK293_Human1.22663895
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20759545
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18802682
68E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17472908
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17428115
70ZNF274_21170338_ChIP-Seq_K562_Hela1.17077786
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.14353983
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12670275
73TFEB_21752829_ChIP-Seq_HELA_Human1.12616521
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09236576
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04218725
76* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03979395
77CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02868502
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01272073
79IRF1_19129219_ChIP-ChIP_H3396_Human0.99835136
80NANOG_16153702_ChIP-ChIP_HESCs_Human0.99458692
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98317671
82SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97962441
83SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97805756
84VDR_21846776_ChIP-Seq_THP-1_Human0.97693297
85* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96555726
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96316739
87CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95566277
88MYC_18940864_ChIP-ChIP_HL60_Human0.94984521
89SPI1_23547873_ChIP-Seq_NB4_Human0.94865348
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94066920
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92932193
92* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90884691
93ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89421125
94TP63_19390658_ChIP-ChIP_HaCaT_Human0.89147928
95ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88016434
96* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86795354
97FUS_26573619_Chip-Seq_HEK293_Human0.86138550
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.86116026
99SOX2_16153702_ChIP-ChIP_HESCs_Human0.84239824
100* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83372706
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83015688
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82524549
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.82237133
104POU5F1_16153702_ChIP-ChIP_HESCs_Human0.81366991
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80554749
106ELK1_22589737_ChIP-Seq_MCF10A_Human0.77304416
107* SOX17_20123909_ChIP-Seq_XEN_Mouse0.75615053
108FLI1_27457419_Chip-Seq_LIVER_Mouse0.74406746
109* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.72994688
110IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.71789892
111NANOG_21062744_ChIP-ChIP_HESCs_Human0.71386389
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.70465600
113ELF5_23300383_ChIP-Seq_T47D_Human0.69880546
114PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.69394634
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.67050301
116SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.64274015
117EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.64226781

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.65419522
2MP0010094_abnormal_chromosome_stability4.90707281
3MP0004957_abnormal_blastocyst_morpholog4.45208120
4MP0003111_abnormal_nucleus_morphology4.41555748
5MP0008057_abnormal_DNA_replication4.28712858
6MP0003077_abnormal_cell_cycle3.98398132
7MP0008058_abnormal_DNA_repair3.50649100
8MP0008007_abnormal_cellular_replicative2.92849751
9MP0002396_abnormal_hematopoietic_system2.82484937
10MP0003806_abnormal_nucleotide_metabolis2.71131257
11MP0008932_abnormal_embryonic_tissue2.59071264
12MP0003123_paternal_imprinting2.39833559
13MP0010352_gastrointestinal_tract_polyps2.34644404
14MP0001730_embryonic_growth_arrest2.31705929
15MP0000350_abnormal_cell_proliferation2.16669749
16MP0010307_abnormal_tumor_latency1.94804545
17MP0003786_premature_aging1.85495277
18MP0005408_hypopigmentation1.83598264
19MP0000490_abnormal_crypts_of1.80765165
20MP0006072_abnormal_retinal_apoptosis1.75170066
21MP0003941_abnormal_skin_development1.64570132
22MP0001672_abnormal_embryogenesis/_devel1.63290471
23MP0005380_embryogenesis_phenotype1.63290471
24MP0006054_spinal_hemorrhage1.62932240
25MP0008877_abnormal_DNA_methylation1.62637715
26MP0001697_abnormal_embryo_size1.62584842
27MP0004808_abnormal_hematopoietic_stem1.58888553
28MP0002080_prenatal_lethality1.57462589
29MP0002019_abnormal_tumor_incidence1.53893100
30MP0003984_embryonic_growth_retardation1.49686834
31MP0002088_abnormal_embryonic_growth/wei1.46417627
32MP0000313_abnormal_cell_death1.46042080
33MP0003186_abnormal_redox_activity1.40862506
34MP0003718_maternal_effect1.40822847
35MP0002102_abnormal_ear_morphology1.37029373
36MP0009333_abnormal_splenocyte_physiolog1.32570141
37MP0002085_abnormal_embryonic_tissue1.29785210
38MP0004197_abnormal_fetal_growth/weight/1.28477923
39MP0002086_abnormal_extraembryonic_tissu1.28464764
40MP0003763_abnormal_thymus_physiology1.28391614
41MP0003937_abnormal_limbs/digits/tail_de1.25285364
42MP0001545_abnormal_hematopoietic_system1.23465028
43MP0005397_hematopoietic_system_phenotyp1.23465028
44MP0000372_irregular_coat_pigmentation1.20604978
45MP0003195_calcinosis1.19891111
46MP0002084_abnormal_developmental_patter1.18579895
47MP0003567_abnormal_fetal_cardiomyocyte1.17413141
48MP0008789_abnormal_olfactory_epithelium1.16108133
49MP0002398_abnormal_bone_marrow1.13697098
50MP0000703_abnormal_thymus_morphology1.11864469
51MP0002722_abnormal_immune_system1.11107657
52MP0000689_abnormal_spleen_morphology1.10165535
53MP0002736_abnormal_nociception_after1.08444553
54MP0005395_other_phenotype1.04996153
55MP0000358_abnormal_cell_content/1.04906173
56MP0001293_anophthalmia1.04735830
57MP0003950_abnormal_plasma_membrane1.03255410
58MP0009053_abnormal_anal_canal0.99344863
59MP0009672_abnormal_birth_weight0.98628746
60MP0003121_genomic_imprinting0.98321647
61MP0002210_abnormal_sex_determination0.97137115
62MP0006036_abnormal_mitochondrial_physio0.96113091
63MP0002234_abnormal_pharynx_morphology0.94637223
64MP0005253_abnormal_eye_physiology0.94094065
65MP0002429_abnormal_blood_cell0.93490651
66MP0001764_abnormal_homeostasis0.92532103
67MP0000858_altered_metastatic_potential0.90736548
68MP0001145_abnormal_male_reproductive0.89596090
69MP0003890_abnormal_embryonic-extraembry0.89533682
70MP0001853_heart_inflammation0.89433063
71MP0003315_abnormal_perineum_morphology0.89152854
72MP0002160_abnormal_reproductive_system0.83869959
73MP0006035_abnormal_mitochondrial_morpho0.82567249
74MP0008875_abnormal_xenobiotic_pharmacok0.82197195
75MP0000647_abnormal_sebaceous_gland0.81676559
76MP0002163_abnormal_gland_morphology0.80487179
77MP0010030_abnormal_orbit_morphology0.80106670
78MP0003136_yellow_coat_color0.80031674
79MP0005023_abnormal_wound_healing0.79184387
80MP0001119_abnormal_female_reproductive0.79015189
81MP0005384_cellular_phenotype0.78053131
82MP0005076_abnormal_cell_differentiation0.78039922
83MP0000598_abnormal_liver_morphology0.77978427
84MP0001286_abnormal_eye_development0.77503862
85MP0000653_abnormal_sex_gland0.77300797
86MP0005266_abnormal_metabolism0.77217822
87MP0002132_abnormal_respiratory_system0.76416017
88MP0000716_abnormal_immune_system0.76310426
89MP0002233_abnormal_nose_morphology0.75828131
90MP0001929_abnormal_gametogenesis0.75178630
91MP0000579_abnormal_nail_morphology0.75087160
92MP0009697_abnormal_copulation0.74832113
93MP0002751_abnormal_autonomic_nervous0.74663190
94MP0001915_intracranial_hemorrhage0.74566283
95MP0005389_reproductive_system_phenotype0.73864920
96MP0002697_abnormal_eye_size0.73718014
97MP0008995_early_reproductive_senescence0.71451728
98MP0005499_abnormal_olfactory_system0.70647180
99MP0005394_taste/olfaction_phenotype0.70647180
100MP0003252_abnormal_bile_duct0.69490093
101MP0000477_abnormal_intestine_morphology0.68904267
102MP0005621_abnormal_cell_physiology0.68066927
103MP0000049_abnormal_middle_ear0.67629753
104MP0006292_abnormal_olfactory_placode0.66637504
105MP0008872_abnormal_physiological_respon0.65921094
106MP0005391_vision/eye_phenotype0.65679973
107MP0003705_abnormal_hypodermis_morpholog0.65647013
108MP0002111_abnormal_tail_morphology0.65540792
109MP0005220_abnormal_exocrine_pancreas0.65383863
110MP0001727_abnormal_embryo_implantation0.65241175
111MP0009703_decreased_birth_body0.65175461
112MP0004782_abnormal_surfactant_physiolog0.65173097
113MP0005084_abnormal_gallbladder_morpholo0.64984928
114MP0009379_abnormal_foot_pigmentation0.64974797
115MP0000537_abnormal_urethra_morphology0.64298185
116MP0005501_abnormal_skin_physiology0.62867672
117MP0004147_increased_porphyrin_level0.62821017
118MP0001346_abnormal_lacrimal_gland0.61932931
119MP0003221_abnormal_cardiomyocyte_apopto0.61506885
120MP0005410_abnormal_fertilization0.61450747
121MP0001529_abnormal_vocalization0.61264231
122MP0001835_abnormal_antigen_presentation0.61047305
123MP0005647_abnormal_sex_gland0.60846091
124MP0000427_abnormal_hair_cycle0.60706046
125MP0002139_abnormal_hepatobiliary_system0.60272275
126MP0003119_abnormal_digestive_system0.60100597
127MP0005075_abnormal_melanosome_morpholog0.59823492
128MP0002254_reproductive_system_inflammat0.59593557
129MP0003566_abnormal_cell_adhesion0.59419310
130MP0005332_abnormal_amino_acid0.58330086
131MP0001800_abnormal_humoral_immune0.57993460
132MP0004133_heterotaxia0.57805739
133MP0001881_abnormal_mammary_gland0.57355726
134MP0003436_decreased_susceptibility_to0.56478258
135MP0005551_abnormal_eye_electrophysiolog0.56369433
136MP0002420_abnormal_adaptive_immunity0.55619477
137MP0004264_abnormal_extraembryonic_tissu0.54011885
138MP0001919_abnormal_reproductive_system0.54004209
139MP0001819_abnormal_immune_cell0.53715009
140MP0002938_white_spotting0.53015907
141MP0003656_abnormal_erythrocyte_physiolo0.52818746
142MP0005365_abnormal_bile_salt0.52801966
143MP0001243_abnormal_dermal_layer0.51644488

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.30377628
2Reticulocytopenia (HP:0001896)4.50018651
3Abnormality of cells of the erythroid lineage (HP:0012130)4.30452846
4Abnormal number of erythroid precursors (HP:0012131)4.27899901
5Breast hypoplasia (HP:0003187)3.83297938
6Oral leukoplakia (HP:0002745)3.76988620
7Aplastic anemia (HP:0001915)3.74458084
8Chromsome breakage (HP:0040012)3.66207291
9Acute necrotizing encephalopathy (HP:0006965)3.49877564
10Acute encephalopathy (HP:0006846)3.47864308
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.44479924
12Abnormality of the anterior horn cell (HP:0006802)3.41756638
13Degeneration of anterior horn cells (HP:0002398)3.41756638
14Colon cancer (HP:0003003)3.41109405
15Increased CSF lactate (HP:0002490)3.23712826
16Abnormal mitochondria in muscle tissue (HP:0008316)3.23241934
17Selective tooth agenesis (HP:0001592)3.18015262
18Abnormality of chromosome stability (HP:0003220)3.16277950
19Medulloblastoma (HP:0002885)3.14780449
20Carpal bone hypoplasia (HP:0001498)3.14102117
21Mitochondrial inheritance (HP:0001427)3.06208048
22Thrombocytosis (HP:0001894)3.03939447
23Patellar aplasia (HP:0006443)3.03471104
24Agnosia (HP:0010524)2.97139856
25Meckel diverticulum (HP:0002245)2.96744737
26Abnormality of the preputium (HP:0100587)2.95645865
27Hepatocellular necrosis (HP:0001404)2.90025668
283-Methylglutaconic aciduria (HP:0003535)2.89863787
29Aplasia/Hypoplasia of the patella (HP:0006498)2.84390972
30Cerebral edema (HP:0002181)2.83726354
3111 pairs of ribs (HP:0000878)2.83662264
32Rough bone trabeculation (HP:0100670)2.81963671
33Abnormality of the ileum (HP:0001549)2.79860618
34Abnormality of the pons (HP:0007361)2.79803908
35Ependymoma (HP:0002888)2.78255513
36Myelodysplasia (HP:0002863)2.74799439
37Lipid accumulation in hepatocytes (HP:0006561)2.74005118
38Multiple enchondromatosis (HP:0005701)2.73831150
39Increased hepatocellular lipid droplets (HP:0006565)2.72667221
40Absent thumb (HP:0009777)2.72477713
41Progressive macrocephaly (HP:0004481)2.70769440
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.68156708
43Microretrognathia (HP:0000308)2.64490983
44Hepatic necrosis (HP:0002605)2.57971665
45Impulsivity (HP:0100710)2.55112709
46* Macrocytic anemia (HP:0001972)2.54525692
47Pallor (HP:0000980)2.53951527
48Bone marrow hypocellularity (HP:0005528)2.51797848
49Lactic acidosis (HP:0003128)2.50872361
50Premature graying of hair (HP:0002216)2.48598874
51Rhabdomyosarcoma (HP:0002859)2.47919424
52Increased serum pyruvate (HP:0003542)2.40869226
53Cerebral hypomyelination (HP:0006808)2.39841701
54Neoplasm of the pancreas (HP:0002894)2.39197381
55Abnormality of the labia minora (HP:0012880)2.36677093
56Small intestinal stenosis (HP:0012848)2.36449940
57Duodenal stenosis (HP:0100867)2.36449940
58Hypoplasia of the pons (HP:0012110)2.35780552
59Abnormality of the renal collecting system (HP:0004742)2.34132059
60Type I transferrin isoform profile (HP:0003642)2.33693984
61Abnormality of glycolysis (HP:0004366)2.26872565
62Pancytopenia (HP:0001876)2.26024207
63Abnormality of serum amino acid levels (HP:0003112)2.25235386
64Abnormality of methionine metabolism (HP:0010901)2.23103260
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21842533
66Abnormality of alanine metabolism (HP:0010916)2.21842533
67Hyperalaninemia (HP:0003348)2.21842533
68Clubbing of toes (HP:0100760)2.20927674
69Sloping forehead (HP:0000340)2.20451870
70Absent radius (HP:0003974)2.19279645
71Abnormal number of incisors (HP:0011064)2.19196383
72Cellular immunodeficiency (HP:0005374)2.18551676
73Abnormality of reticulocytes (HP:0004312)2.16592887
74IgM deficiency (HP:0002850)2.13816666
75Basal cell carcinoma (HP:0002671)2.10929686
76Trismus (HP:0000211)2.10028324
77Horseshoe kidney (HP:0000085)2.09975721
78Slender long bone (HP:0003100)2.09384403
79Ectopic kidney (HP:0000086)2.08639723
80Respiratory failure (HP:0002878)2.08503104
81Reduced antithrombin III activity (HP:0001976)2.07179258
82Abnormality of the duodenum (HP:0002246)2.07170446
83Abnormal trabecular bone morphology (HP:0100671)2.05511004
84Hyperglycinemia (HP:0002154)2.05270829
85Tracheoesophageal fistula (HP:0002575)2.05104258
86* Abnormality of pyrimidine metabolism (HP:0004353)2.04724931
87Lethargy (HP:0001254)2.02516142
88Lymphoma (HP:0002665)2.01254728
89Nephroblastoma (Wilms tumor) (HP:0002667)2.00964508
90Testicular atrophy (HP:0000029)2.00511082
91Aplasia involving forearm bones (HP:0009822)1.99711296
92Absent forearm bone (HP:0003953)1.99711296
93Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.99607481
94Abnormal lung lobation (HP:0002101)1.99324853
95Hyperglycinuria (HP:0003108)1.97001520
96Squamous cell carcinoma (HP:0002860)1.95765303
97Amaurosis fugax (HP:0100576)1.95551216
98Atresia of the external auditory canal (HP:0000413)1.95479431
99Secondary amenorrhea (HP:0000869)1.94695124
100Atrophy/Degeneration involving motor neurons (HP:0007373)1.94273983
101Hypoplasia of the capital femoral epiphysis (HP:0003090)1.94014716
102Missing ribs (HP:0000921)1.92061638
103Abnormality of aspartate family amino acid metabolism (HP:0010899)1.90762126
104Proximal placement of thumb (HP:0009623)1.90395619
105Embryonal renal neoplasm (HP:0011794)1.90168918
106Exercise intolerance (HP:0003546)1.90165358
107Deviation of the thumb (HP:0009603)1.89537281
108Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.89467463
109Abnormality of the carotid arteries (HP:0005344)1.87521979
110Triphalangeal thumb (HP:0001199)1.87478777
111Sparse eyelashes (HP:0000653)1.87067381
112Prominent metopic ridge (HP:0005487)1.85636023
113Duplicated collecting system (HP:0000081)1.85180719
114Neoplasm of the colon (HP:0100273)1.84318292
115Abnormality of DNA repair (HP:0003254)1.83150700
116Leukodystrophy (HP:0002415)1.82995166
117Short thumb (HP:0009778)1.82989987
118Increased nuchal translucency (HP:0010880)1.82727969
119Renal Fanconi syndrome (HP:0001994)1.81683155
120Facial cleft (HP:0002006)1.79476821
121Premature ovarian failure (HP:0008209)1.79063431
122CNS demyelination (HP:0007305)1.78297005
123Optic nerve coloboma (HP:0000588)1.78147891
124Increased serum lactate (HP:0002151)1.77985410
125Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.77270403
126Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77090794
127Cafe-au-lait spot (HP:0000957)1.76094498
128Abnormality of serine family amino acid metabolism (HP:0010894)1.75116926
129Abnormality of glycine metabolism (HP:0010895)1.75116926
130Hypobetalipoproteinemia (HP:0003563)1.74880469
131Neoplasm of the adrenal gland (HP:0100631)1.74448888
132Poor head control (HP:0002421)1.74440999
133Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74048863
134Abnormal protein N-linked glycosylation (HP:0012347)1.74048863
135Abnormal protein glycosylation (HP:0012346)1.74048863
136Abnormal glycosylation (HP:0012345)1.74048863
137Spastic diplegia (HP:0001264)1.74033384
138Glossoptosis (HP:0000162)1.71797529
139Microvesicular hepatic steatosis (HP:0001414)1.71554311
140Pendular nystagmus (HP:0012043)1.70889274
141High pitched voice (HP:0001620)1.70065762
142Methylmalonic aciduria (HP:0012120)1.70037035
143Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.69903040
144Decreased activity of mitochondrial respiratory chain (HP:0008972)1.69903040
145Progressive muscle weakness (HP:0003323)1.68830795
146Optic disc pallor (HP:0000543)1.68760367
147Cleft eyelid (HP:0000625)1.68414363
148Abnormality of the calcaneus (HP:0008364)1.67472627

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.39606121
2CDC74.34982362
3BUB14.10315317
4VRK23.76351580
5EIF2AK13.49716258
6NUAK13.00528367
7PBK2.88650740
8BRSK22.76000096
9TSSK62.68306106
10STK162.59931763
11EIF2AK32.48975555
12SRPK12.30225864
13NEK22.27486235
14PASK2.25335236
15NEK12.23234505
16ACVR1B2.03976208
17MST42.03886046
18NME22.03209642
19TTK1.97237798
20TAF11.90056780
21PLK41.87641870
22PLK11.86844532
23TESK21.79159802
24VRK11.78925080
25ATR1.73990878
26BRSK11.73213734
27CDK71.68083426
28TLK11.67006235
29MKNK11.66675604
30LATS11.64155457
31RPS6KB21.57250327
32BMPR1B1.55415220
33AURKB1.55148835
34EEF2K1.54811599
35RPS6KA41.52475398
36FLT31.51220897
37NME11.51065385
38MAP4K21.49430548
39TRIM281.45923779
40PLK31.45187239
41PDK21.43069060
42TGFBR11.40459284
43MAP3K81.35335305
44CCNB11.34796421
45SCYL21.34153438
46DYRK31.29931541
47BCKDK1.24022361
48CDK41.23947938
49CHEK21.18836609
50STK391.16392219
51STK101.13632416
52PAK41.11731965
53WNK41.10859673
54MKNK21.10610793
55AURKA1.09076179
56CHEK11.08686278
57PIM21.08331621
58PKN21.05914161
59WNK31.01525489
60MAP4K10.98477108
61ZAK0.91815694
62CDK120.89140789
63MAP3K120.87664047
64STK40.86778125
65CDK80.85308876
66TESK10.84953859
67EPHA20.83315522
68MAP2K30.82986558
69PIM10.82783439
70KDR0.81762426
71ATM0.77923633
72LRRK20.77708689
73CDK20.76814805
74CSNK1G10.74213044
75CSNK2A20.73435813
76ITK0.73330421
77FRK0.70641956
78EIF2AK20.69659547
79CSNK2A10.69633130
80CSNK1G30.69610583
81TEC0.67715830
82SMG10.66087563
83NEK90.65311381
84ERBB40.64597199
85MAP3K100.63948588
86GRK10.62906464
87BTK0.61701547
88CSNK1A1L0.60119689
89ALK0.57805050
90BRD40.56783598
91CLK10.56461405
92CDK60.55302259
93OXSR10.53625430
94CDK10.53246905
95PAK10.52918112
96MAPKAPK30.51842637
97MAP3K110.51579401
98TAOK20.49295312
99MAPKAPK50.48869127
100ZAP700.48279282
101TNIK0.47557710
102PRKCI0.46689260
103ERBB30.45925719
104STK38L0.45760272
105IRAK30.45547152
106IRAK40.44720616
107CDK30.44200985
108MAP3K30.43060885
109DAPK10.43038681
110CSF1R0.42566845
111BRAF0.42281307
112CSNK1G20.42109415
113KIT0.41258254
114DYRK20.40807808
115INSRR0.39900727
116IRAK10.39899242
117PTK2B0.39009438
118CSNK1A10.38985363
119IRAK20.36577214
120MAP2K70.36461866
121BCR0.34931682
122GSK3A0.34916953
123ILK0.34665212
124MST1R0.33824708
125JAK30.32328859
126RPS6KA50.31109363
127FGFR10.30654156
128ABL20.30251355
129MELK0.29461808
130PLK20.28399964
131PRKDC0.27957526
132STK30.27742942
133GRK60.26582551
134RPS6KB10.26241789
135AKT20.25350874
136TRIB30.24962408
137MAPK110.24762144
138MTOR0.24309050
139CSNK1E0.23522796
140PAK20.23195829
141LYN0.22173838
142TYK20.21765694

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.41458135
2Mismatch repair_Homo sapiens_hsa034304.38417058
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.41143627
4Ribosome_Homo sapiens_hsa030103.17619194
5One carbon pool by folate_Homo sapiens_hsa006703.14213554
6Proteasome_Homo sapiens_hsa030503.11836382
7Base excision repair_Homo sapiens_hsa034103.03852490
8Spliceosome_Homo sapiens_hsa030403.03591045
9RNA polymerase_Homo sapiens_hsa030202.97650272
10Homologous recombination_Homo sapiens_hsa034402.91866897
11RNA transport_Homo sapiens_hsa030132.84026938
12Nucleotide excision repair_Homo sapiens_hsa034202.81469623
13* Pyrimidine metabolism_Homo sapiens_hsa002402.53418031
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.51190120
15Cell cycle_Homo sapiens_hsa041102.50945093
16Non-homologous end-joining_Homo sapiens_hsa034502.01101314
17Oxidative phosphorylation_Homo sapiens_hsa001901.99214578
18Fanconi anemia pathway_Homo sapiens_hsa034601.98732407
19RNA degradation_Homo sapiens_hsa030181.69072192
20Basal transcription factors_Homo sapiens_hsa030221.48830518
21Propanoate metabolism_Homo sapiens_hsa006401.48599095
22Fatty acid elongation_Homo sapiens_hsa000621.43421296
23Selenocompound metabolism_Homo sapiens_hsa004501.39598610
24p53 signaling pathway_Homo sapiens_hsa041151.38916706
25Purine metabolism_Homo sapiens_hsa002301.34682694
26mRNA surveillance pathway_Homo sapiens_hsa030151.34437224
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30781172
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.26649167
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24019721
30Biosynthesis of amino acids_Homo sapiens_hsa012301.23899677
31Folate biosynthesis_Homo sapiens_hsa007901.22385446
32Steroid biosynthesis_Homo sapiens_hsa001001.17134903
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16845251
34Protein export_Homo sapiens_hsa030601.14688376
35Pentose phosphate pathway_Homo sapiens_hsa000301.14454413
36Systemic lupus erythematosus_Homo sapiens_hsa053221.08796937
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06485867
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.06061122
39* Drug metabolism - other enzymes_Homo sapiens_hsa009831.03655981
40Epstein-Barr virus infection_Homo sapiens_hsa051691.02175559
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99069073
42Alzheimers disease_Homo sapiens_hsa050100.98746544
43Antigen processing and presentation_Homo sapiens_hsa046120.97349716
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94736997
45Carbon metabolism_Homo sapiens_hsa012000.87928807
46Sulfur metabolism_Homo sapiens_hsa009200.87131660
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86723597
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85327868
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83828634
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80566057
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80553083
52Herpes simplex infection_Homo sapiens_hsa051680.79000128
53Viral carcinogenesis_Homo sapiens_hsa052030.78993617
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77225889
55Sulfur relay system_Homo sapiens_hsa041220.75022838
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73637645
57Glutathione metabolism_Homo sapiens_hsa004800.71172937
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69386942
59N-Glycan biosynthesis_Homo sapiens_hsa005100.69241825
60Legionellosis_Homo sapiens_hsa051340.68238298
61Butanoate metabolism_Homo sapiens_hsa006500.66403490
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64563510
63Vitamin B6 metabolism_Homo sapiens_hsa007500.61907817
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61842013
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60975148
66Oocyte meiosis_Homo sapiens_hsa041140.58713495
67Galactose metabolism_Homo sapiens_hsa000520.58240978
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55660727
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55576736
70HTLV-I infection_Homo sapiens_hsa051660.54996929
71Tryptophan metabolism_Homo sapiens_hsa003800.53995878
72Fatty acid metabolism_Homo sapiens_hsa012120.53420966
73Thyroid cancer_Homo sapiens_hsa052160.51640391
74Fructose and mannose metabolism_Homo sapiens_hsa000510.49774846
75Fatty acid degradation_Homo sapiens_hsa000710.47048379
76Chemical carcinogenesis_Homo sapiens_hsa052040.45513405
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.45253388
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43959676
79Arginine biosynthesis_Homo sapiens_hsa002200.42329771
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41012254
81Retinol metabolism_Homo sapiens_hsa008300.39423681
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39351559
83Primary immunodeficiency_Homo sapiens_hsa053400.38211083
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38137784
85* Metabolic pathways_Homo sapiens_hsa011000.34684692
86Pyruvate metabolism_Homo sapiens_hsa006200.34534103
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33891531
88Small cell lung cancer_Homo sapiens_hsa052220.32010239
89Apoptosis_Homo sapiens_hsa042100.29589610
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29518144
91Huntingtons disease_Homo sapiens_hsa050160.29205238
92Measles_Homo sapiens_hsa051620.27670582
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27147088
94Nitrogen metabolism_Homo sapiens_hsa009100.26647173
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25879722
96MicroRNAs in cancer_Homo sapiens_hsa052060.25430915
97Tyrosine metabolism_Homo sapiens_hsa003500.24583648
98Renin-angiotensin system_Homo sapiens_hsa046140.22294317
99Fat digestion and absorption_Homo sapiens_hsa049750.21907123
100Arginine and proline metabolism_Homo sapiens_hsa003300.21416393
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19716779
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.19553320
103Hepatitis B_Homo sapiens_hsa051610.19408444
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18331298
105Phototransduction_Homo sapiens_hsa047440.17405407
106Lysine degradation_Homo sapiens_hsa003100.17213980
107Alcoholism_Homo sapiens_hsa050340.16692711
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.15558844
109Cardiac muscle contraction_Homo sapiens_hsa042600.15018670
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.14816684
111Basal cell carcinoma_Homo sapiens_hsa052170.14369145
112Parkinsons disease_Homo sapiens_hsa050120.13953079
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.13523864
114Bladder cancer_Homo sapiens_hsa052190.12104986
115Influenza A_Homo sapiens_hsa051640.11942031
116Vitamin digestion and absorption_Homo sapiens_hsa049770.11581163
117Shigellosis_Homo sapiens_hsa051310.11498645
118beta-Alanine metabolism_Homo sapiens_hsa004100.10181348
119HIF-1 signaling pathway_Homo sapiens_hsa040660.08563868
120Chronic myeloid leukemia_Homo sapiens_hsa052200.07933759
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.07040797
122Acute myeloid leukemia_Homo sapiens_hsa052210.06934012
123Caffeine metabolism_Homo sapiens_hsa002320.06390265
124Phenylalanine metabolism_Homo sapiens_hsa003600.06253341
125Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.06115752
126Peroxisome_Homo sapiens_hsa041460.05972713
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.05847936
128TGF-beta signaling pathway_Homo sapiens_hsa043500.05805117
129Colorectal cancer_Homo sapiens_hsa052100.05404291

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