ULK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)7.63555406
2maintenance of protein location in nucleus (GO:0051457)6.70393015
3negative regulation of erythrocyte differentiation (GO:0045647)6.11263151
4interferon-gamma production (GO:0032609)6.10345157
5somite rostral/caudal axis specification (GO:0032525)5.06933066
6regulation of MHC class I biosynthetic process (GO:0045343)4.91122959
7cytidine deamination (GO:0009972)4.55941559
8cytidine metabolic process (GO:0046087)4.55941559
9cytidine catabolic process (GO:0006216)4.55941559
10nucleoside transmembrane transport (GO:1901642)4.52260341
11regulation of cilium movement (GO:0003352)4.46357431
12response to dietary excess (GO:0002021)4.40327024
13negative regulation of telomerase activity (GO:0051974)4.24950419
14regulation of mammary gland epithelial cell proliferation (GO:0033599)4.24848094
15regulation of response to osmotic stress (GO:0047484)4.21703393
16tachykinin receptor signaling pathway (GO:0007217)4.10636523
17mitochondrion distribution (GO:0048311)4.07085391
18mannose metabolic process (GO:0006013)4.04146320
19histone H4-K8 acetylation (GO:0043982)4.02577294
20histone H4-K5 acetylation (GO:0043981)4.02577294
21regulation of telomere maintenance via telomerase (GO:0032210)3.99855774
22muscle organ morphogenesis (GO:0048644)3.96902448
23negative regulation of cell size (GO:0045792)3.94610907
24regulation of apoptotic process involved in morphogenesis (GO:1902337)3.94439232
25negative regulation of telomere maintenance (GO:0032205)3.91750794
26histone H4-K12 acetylation (GO:0043983)3.81502018
27regulation of ARF protein signal transduction (GO:0032012)3.81055267
28NADH metabolic process (GO:0006734)3.78147548
29negative regulation of epidermis development (GO:0045683)3.75969574
30hormone catabolic process (GO:0042447)3.72550795
31coenzyme catabolic process (GO:0009109)3.72288252
32thymic T cell selection (GO:0045061)3.65153559
33maintenance of protein localization in organelle (GO:0072595)3.60215726
34response to pheromone (GO:0019236)3.59887850
35regulation of ARF GTPase activity (GO:0032312)3.59691346
36activation of MAPKKK activity (GO:0000185)3.58211329
37nucleoside transport (GO:0015858)3.55338851
38negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.50629765
39peptidyl-tyrosine autophosphorylation (GO:0038083)3.50214239
40synaptic vesicle exocytosis (GO:0016079)3.49424721
41retinal rod cell development (GO:0046548)3.48205008
42phenol-containing compound catabolic process (GO:0019336)3.46710440
43regulation of nuclear cell cycle DNA replication (GO:0033262)3.46595606
44pyrimidine ribonucleoside catabolic process (GO:0046133)3.44085709
45regulation of isotype switching to IgG isotypes (GO:0048302)3.42656765
46regulation of interleukin-2 biosynthetic process (GO:0045076)3.36207617
47primitive streak formation (GO:0090009)3.32865267
48histone H4-K16 acetylation (GO:0043984)3.32436480
49negative regulation of interleukin-2 production (GO:0032703)3.32188791
50adaptation of signaling pathway (GO:0023058)3.31054283
51histone H3-K4 methylation (GO:0051568)3.26858388
52regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.26351092
53mucosal-associated lymphoid tissue development (GO:0048537)3.26034397
54Peyers patch development (GO:0048541)3.26034397
55quinone metabolic process (GO:1901661)3.25984288
56histone H3-K4 trimethylation (GO:0080182)3.25180579
57positive regulation of histone deacetylation (GO:0031065)3.25079817
58antigen processing and presentation of endogenous antigen (GO:0019883)3.25020727
59protein kinase C signaling (GO:0070528)3.24832992
60negative regulation of systemic arterial blood pressure (GO:0003085)3.23197691
61positive regulation of protein deacetylation (GO:0090312)3.22465822
62positive regulation of synapse maturation (GO:0090129)3.21362820
63regulation of telomere maintenance (GO:0032204)3.21079991
64histone H4 deacetylation (GO:0070933)3.19875308
65negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.19511446
66negative regulation of viral release from host cell (GO:1902187)3.19016700
67synaptic vesicle docking involved in exocytosis (GO:0016081)3.18074864
68regulation of gamma-delta T cell differentiation (GO:0045586)3.16641349
69retinoic acid receptor signaling pathway (GO:0048384)3.13940425
70T cell selection (GO:0045058)3.11543773
71branching involved in mammary gland duct morphogenesis (GO:0060444)3.11410002
72establishment of endothelial barrier (GO:0061028)3.05845540
73proline biosynthetic process (GO:0006561)3.04270832
74negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.03902625
75negative regulation of cell cycle G2/M phase transition (GO:1902750)3.01966255
76G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.00426421
77histone H3 deacetylation (GO:0070932)2.97946660
78regulation of cytokine production involved in inflammatory response (GO:1900015)2.97635563
79antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.96850943
80creatine metabolic process (GO:0006600)2.96077352
81signal complex assembly (GO:0007172)2.95262466
82regulation of hydrogen peroxide metabolic process (GO:0010310)2.94895257
83regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.93952058
84positive regulation of Rap GTPase activity (GO:0032854)2.93141203
85glutamate secretion (GO:0014047)2.92354143
86regulation of cholesterol metabolic process (GO:0090181)2.89060973
87phosphatidylinositol 3-kinase signaling (GO:0014065)2.88044310
88positive T cell selection (GO:0043368)2.87464892
89regulation of gamma-delta T cell activation (GO:0046643)2.85650065
90nonmotile primary cilium assembly (GO:0035058)2.85265326
91rRNA transcription (GO:0009303)2.85028834
92negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.83486165
93negative regulation of cell killing (GO:0031342)2.83486165
94regulation of chromatin binding (GO:0035561)2.82466525
95negative regulation of epidermal cell differentiation (GO:0045605)2.82023330
96synaptic vesicle maturation (GO:0016188)2.80790427
97cellular modified amino acid catabolic process (GO:0042219)2.80351571
98negative regulation of bone resorption (GO:0045779)2.79340082
99positive regulation of odontogenesis (GO:0042482)2.79182722
100icosanoid secretion (GO:0032309)2.77684068
101arachidonic acid secretion (GO:0050482)2.77684068
102positive regulation of Cdc42 GTPase activity (GO:0043089)2.76867860
103Arp2/3 complex-mediated actin nucleation (GO:0034314)2.76145027
104regulation of B cell receptor signaling pathway (GO:0050855)2.76055310
105retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.76021370
106cell fate commitment involved in formation of primary germ layer (GO:0060795)2.75997479
107detection of temperature stimulus (GO:0016048)2.75323202
108activation of Rac GTPase activity (GO:0032863)2.75067276
109T cell differentiation involved in immune response (GO:0002292)2.73763372
110alpha-beta T cell differentiation involved in immune response (GO:0002293)2.73763372
111alpha-beta T cell activation involved in immune response (GO:0002287)2.73763372
112positive regulation of defense response to virus by host (GO:0002230)2.73096689
113regulation of Rap GTPase activity (GO:0032317)2.72030755
114intracellular estrogen receptor signaling pathway (GO:0030520)2.71465279
115poly(A)+ mRNA export from nucleus (GO:0016973)2.71208371
116regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.70931477
117antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.69665233
118negative thymic T cell selection (GO:0045060)2.69128237
119sodium ion export (GO:0071436)2.69113319
120proline transport (GO:0015824)2.66914184
121negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.66448126
122regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.66353130
123regulation of alkaline phosphatase activity (GO:0010692)2.65675319
124positive regulation of triglyceride lipase activity (GO:0061365)2.64088759
125positive regulation of lipoprotein lipase activity (GO:0051006)2.64088759
126regulation of microtubule-based movement (GO:0060632)2.64066644
127positive regulation of DNA-dependent DNA replication (GO:2000105)2.63580843
128epithelial cell differentiation involved in prostate gland development (GO:0060742)2.63236676
129rRNA methylation (GO:0031167)2.62779381
130response to muramyl dipeptide (GO:0032495)2.61358961
131negative T cell selection (GO:0043383)2.61197856
132phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.60627176
133detection of bacterium (GO:0016045)2.60347998
134negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.60090760
135negative regulation of granulocyte differentiation (GO:0030853)2.59977157
136activation of JUN kinase activity (GO:0007257)2.59813464
137cell proliferation involved in metanephros development (GO:0072203)2.59212813
138positive regulation of B cell differentiation (GO:0045579)2.58506631
139regulation of synaptic vesicle exocytosis (GO:2000300)2.58080993
140positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.57767384
141transepithelial transport (GO:0070633)2.57161063
142establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.56125223
143mitochondrion transport along microtubule (GO:0047497)2.56125223
144establishment of mitochondrion localization (GO:0051654)2.54686087
145glycolipid biosynthetic process (GO:0009247)2.54117459
146negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.53822273
147calcium-mediated signaling using intracellular calcium source (GO:0035584)2.53278360
148leukocyte aggregation (GO:0070486)2.51270618
149negative regulation of toll-like receptor signaling pathway (GO:0034122)2.50958415
150regulation of respiratory burst (GO:0060263)2.50155048
151actin filament polymerization (GO:0030041)2.50024379
152regulation of necrotic cell death (GO:0010939)2.48999642
153natural killer cell activation (GO:0030101)2.48893660
154positive regulation of gamma-delta T cell activation (GO:0046645)2.48467169
155positive thymic T cell selection (GO:0045059)2.48442020
156regulation of synapse maturation (GO:0090128)2.46135260
157regulation of monocyte differentiation (GO:0045655)2.44542004
158positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.44322903
159tricarboxylic acid metabolic process (GO:0072350)2.44285980
160positive regulation of tissue remodeling (GO:0034105)2.43686797
1613-UTR-mediated mRNA stabilization (GO:0070935)2.43400032
162regulation of leukocyte degranulation (GO:0043300)2.43239219
163proline metabolic process (GO:0006560)2.42338915
164mammary gland alveolus development (GO:0060749)2.41952813
165neurotransmitter secretion (GO:0007269)2.41605642
166UV protection (GO:0009650)2.41218812
167hypotonic response (GO:0006971)2.41142938
168regulation of regulated secretory pathway (GO:1903305)2.39641942
169regulation of mast cell degranulation (GO:0043304)2.39379216
170cell migration in hindbrain (GO:0021535)2.39336083
171regulation of female receptivity (GO:0045924)2.39149523
172negative regulation of myotube differentiation (GO:0010832)2.36743770
173apoptotic process involved in morphogenesis (GO:0060561)2.35981105
174regulation of interleukin-4 production (GO:0032673)2.34555191
175neuronal ion channel clustering (GO:0045161)2.32717353
176cell volume homeostasis (GO:0006884)2.32621978
177entrainment of circadian clock by photoperiod (GO:0043153)2.32532567
178female mating behavior (GO:0060180)2.32325753
179cytoskeletal anchoring at plasma membrane (GO:0007016)2.31947908
180negative regulation of necroptotic process (GO:0060546)2.31576404
181regulation of myeloid leukocyte mediated immunity (GO:0002886)2.31532336
1822-oxoglutarate metabolic process (GO:0006103)2.30632135
183mature B cell differentiation involved in immune response (GO:0002313)2.29988161
184detection of other organism (GO:0098543)2.28377182
185retrograde transport, endosome to Golgi (GO:0042147)2.28281677
186oxaloacetate metabolic process (GO:0006107)2.27959069
187germinal center formation (GO:0002467)2.27612131
188doxorubicin metabolic process (GO:0044598)11.8590102
189daunorubicin metabolic process (GO:0044597)11.8590102
190polyketide metabolic process (GO:0030638)11.8590102

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.41572885
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.91965716
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.91965716
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.91965716
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.22745655
6VDR_21846776_ChIP-Seq_THP-1_Human2.99091917
7TP63_19390658_ChIP-ChIP_HaCaT_Human2.52083434
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.44100495
9SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.35094965
10KDM2B_26808549_Chip-Seq_DND41_Human2.27995478
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18042245
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.16299919
13P68_20966046_ChIP-Seq_HELA_Human2.12751589
14RACK7_27058665_Chip-Seq_MCF-7_Human2.12342181
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.12057070
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.10248466
17NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.09999004
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.08680609
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.04387588
20CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.02619362
21* TET1_21451524_ChIP-Seq_MESCs_Mouse2.00865488
22IRF1_19129219_ChIP-ChIP_H3396_Human1.98712673
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.92179258
24CDX2_20551321_ChIP-Seq_CACO-2_Human1.91689955
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87289214
26SCL_19346495_ChIP-Seq_HPC-7_Human1.81280692
27SA1_27219007_Chip-Seq_ERYTHROID_Human1.80418797
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79420523
29SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.79035137
30SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.78432517
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78380838
32EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.76416787
33CTCF_27219007_Chip-Seq_ERYTHROID_Human1.74975737
34ELF1_20517297_ChIP-Seq_JURKAT_Human1.74020811
35SRY_22984422_ChIP-ChIP_TESTIS_Rat1.69534029
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66659672
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.66577342
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.65462435
39BCOR_27268052_Chip-Seq_Bcells_Human1.64523890
40RUNX_20019798_ChIP-Seq_JUKART_Human1.63451409
41* MAF_26560356_Chip-Seq_TH2_Human1.62457203
42BCL6_27268052_Chip-Seq_Bcells_Human1.62203189
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59345069
44MAF_26560356_Chip-Seq_TH1_Human1.56974994
45UTX_26944678_Chip-Seq_JUKART_Human1.55836098
46VDR_22108803_ChIP-Seq_LS180_Human1.54055936
47CREB1_26743006_Chip-Seq_LNCaP_Human1.53637573
48VDR_24763502_ChIP-Seq_THP-1_Human1.52373124
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.49698897
50TCF3_18692474_ChIP-Seq_MESCs_Mouse1.49060955
51NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.48872345
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46736311
53SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41937177
54* CTCF_27219007_Chip-Seq_Bcells_Human1.41503193
55KDM2B_26808549_Chip-Seq_JURKAT_Human1.39623766
56MYC_22102868_ChIP-Seq_BL_Human1.36115763
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.35801410
58ZNF263_19887448_ChIP-Seq_K562_Human1.35422043
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.34291358
60CTCF_26484167_Chip-Seq_Bcells_Mouse1.32767655
61SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.32259618
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32005832
63MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30978957
64UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30366524
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.30059037
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30004301
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29139533
68IRF8_21731497_ChIP-ChIP_J774_Mouse1.28619996
69PHF8_20622854_ChIP-Seq_HELA_Human1.27413762
70TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.26899500
71* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26779621
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26701556
73TCF7_22412390_ChIP-Seq_EML_Mouse1.26323480
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25659387
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25534310
76SA1_27219007_Chip-Seq_Bcells_Human1.25522984
77DROSHA_22980978_ChIP-Seq_HELA_Human1.25362540
78* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25158487
79SPI1_23127762_ChIP-Seq_K562_Human1.24864962
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23191624
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23099128
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22924310
83E2F1_20622854_ChIP-Seq_HELA_Human1.22650246
84SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.22552099
85CTCF_21964334_ChIP-Seq_BJAB-B_Human1.22209220
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21608531
87NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.21103419
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20891620
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20793714
90NCOR1_26117541_ChIP-Seq_K562_Human1.20614471
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20125373
92* ETS1_21867929_ChIP-Seq_TH2_Mouse1.19283190
93HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17972971
94CIITA_25753668_ChIP-Seq_RAJI_Human1.16860068
95E2F1_17053090_ChIP-ChIP_MCF-7_Human1.15516777
96RUNX1_27514584_Chip-Seq_MCF-7_Human1.15307292
97NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14936853
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14352628
99MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14299612
100SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.14108955
101EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13654416
102RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13654416
103CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13618395
104FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13606210
105ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12622379
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11956933
107SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11768254
108SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11610509
109TP63_22573176_ChIP-Seq_HFKS_Human1.11148066
110WT1_19549856_ChIP-ChIP_CCG9911_Human1.09703421
111GBX2_23144817_ChIP-Seq_PC3_Human1.09512752
112PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08520844
113* CTCF_21964334_Chip-Seq_Bcells_Human1.07701166
114SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06774816
115GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06554883
116P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05946907
117* RARB_24833708_ChIP-Seq_LIVER_Mouse1.05444472
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05241630
119KDM2B_26808549_Chip-Seq_K562_Human1.05207407
120* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05081201
121CTCF_20526341_ChIP-Seq_ESCs_Human1.05058895
122CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04807752
123POU5F1_16518401_ChIP-PET_MESCs_Mouse1.04215750
124BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04101783
125OCT4_19829295_ChIP-Seq_ESCs_Human1.03592808
126NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03443838
127* RARA_24833708_ChIP-Seq_LIVER_Mouse1.02731820
128YY1_22570637_ChIP-Seq_MALME-3M_Human1.02333251
129* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02000988
130RARB_27405468_Chip-Seq_BRAIN_Mouse1.00605451
131ESR2_21235772_ChIP-Seq_MCF-7_Human0.99150094
132SMAD3_21741376_ChIP-Seq_HESCs_Human0.98857852
133RNF2_27304074_Chip-Seq_NSC_Mouse0.97938453
134IRF8_27001747_Chip-Seq_BMDM_Mouse0.97894061
135NANOG_18692474_ChIP-Seq_MESCs_Mouse0.97521398
136IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97198598
137HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95400826
138TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94716160
139BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94232332
140TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93608636
141PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.90921652
142GATA2_21666600_ChIP-Seq_HMVEC_Human0.90315727
143STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.90121226
144SMC4_20622854_ChIP-Seq_HELA_Human0.90070326
145SMAD_19615063_ChIP-ChIP_OVARY_Human0.89738364
146SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.89047685
147BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.88703176
148ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87411920
149* MYB_26560356_Chip-Seq_TH1_Human0.85614128
150LXR_22292898_ChIP-Seq_THP-1_Human0.85519305
151WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85069367
152RING1B_27294783_Chip-Seq_NPCs_Mouse0.84670225
153TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84558802
154RNF2_27304074_Chip-Seq_ESCs_Mouse0.83403287
155FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.83192365
156MYB_26560356_Chip-Seq_TH2_Human0.81415435
157NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79787105
158RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.79698158
159TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.79033718
160SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.78665298
161STAT3_18555785_ChIP-Seq_MESCs_Mouse0.78621310
162SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.77577202
163AHR_22903824_ChIP-Seq_MCF-7_Human0.77046616
164POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76270482
165REST_18959480_ChIP-ChIP_MESCs_Mouse0.75261325
166WT1_25993318_ChIP-Seq_PODOCYTE_Human0.74817469
167EZH2_27294783_Chip-Seq_ESCs_Mouse0.74564439
168JARID2_20075857_ChIP-Seq_MESCs_Mouse0.74344509
169STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.74009010
170KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.73735600
171MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.73091292
172REST_21632747_ChIP-Seq_MESCs_Mouse0.72989224
173RUNX1_22412390_ChIP-Seq_EML_Mouse0.72567472
174ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72306532
175KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.72165537
176DNAJC2_21179169_ChIP-ChIP_NT2_Human0.72104480
177ZNF217_24962896_ChIP-Seq_MCF-7_Human0.71883305
178MTF2_20144788_ChIP-Seq_MESCs_Mouse0.71189733

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat5.89319000
2MP0006292_abnormal_olfactory_placode4.88114080
3MP0005499_abnormal_olfactory_system4.52481787
4MP0005394_taste/olfaction_phenotype4.52481787
5MP0003011_delayed_dark_adaptation3.83565175
6MP0005075_abnormal_melanosome_morpholog3.62307645
7MP0004264_abnormal_extraembryonic_tissu3.34842585
8MP0005058_abnormal_lysosome_morphology3.06821006
9MP0008260_abnormal_autophagy3.01384199
10MP0009278_abnormal_bone_marrow2.97546033
11MP0002822_catalepsy2.84252460
12MP0009840_abnormal_foam_cell2.67992688
13MP0006082_CNS_inflammation2.65029182
14MP0008789_abnormal_olfactory_epithelium2.60792706
15MP0003183_abnormal_peptide_metabolism2.56283503
16MP0000678_abnormal_parathyroid_gland2.43310769
17MP0004858_abnormal_nervous_system2.37811290
18MP0005451_abnormal_body_composition2.35294862
19MP0002277_abnormal_respiratory_mucosa2.34320238
20MP0003191_abnormal_cellular_cholesterol2.31086352
21MP0000465_gastrointestinal_hemorrhage2.20421237
22MP0003303_peritoneal_inflammation2.19852788
23MP0005310_abnormal_salivary_gland2.13489573
24MP0005387_immune_system_phenotype2.11347157
25MP0001790_abnormal_immune_system2.11347157
26MP0005671_abnormal_response_to2.04255621
27MP0008961_abnormal_basal_metabolism2.01222470
28MP0002249_abnormal_larynx_morphology1.98210819
29MP0004381_abnormal_hair_follicle1.97577267
30MP0004043_abnormal_pH_regulation1.94201503
31MP0001873_stomach_inflammation1.88788941
32MP0005257_abnormal_intraocular_pressure1.86224799
33MP0003329_amyloid_beta_deposits1.84477720
34MP0001984_abnormal_olfaction1.83677537
35MP0002332_abnormal_exercise_endurance1.81366966
36MP0005409_darkened_coat_color1.80029514
37MP0005397_hematopoietic_system_phenotyp1.79372604
38MP0001545_abnormal_hematopoietic_system1.79372604
39MP0002127_abnormal_cardiovascular_syste1.78534588
40MP0002796_impaired_skin_barrier1.77326241
41MP0003938_abnormal_ear_development1.75156328
42MP0003122_maternal_imprinting1.72624553
43MP0003866_abnormal_defecation1.72534951
44MP0004185_abnormal_adipocyte_glucose1.71113964
45MP0010155_abnormal_intestine_physiology1.67429856
46MP0005666_abnormal_adipose_tissue1.67229917
47MP0001800_abnormal_humoral_immune1.66705886
48MP0002396_abnormal_hematopoietic_system1.66378220
49MP0005360_urolithiasis1.65615848
50MP0003890_abnormal_embryonic-extraembry1.62871394
51MP0010234_abnormal_vibrissa_follicle1.56526380
52MP0003705_abnormal_hypodermis_morpholog1.53135790
53MP0003172_abnormal_lysosome_physiology1.50610185
54MP0003879_abnormal_hair_cell1.46130336
55MP0005464_abnormal_platelet_physiology1.44971068
56MP0008569_lethality_at_weaning1.42065920
57MP0009333_abnormal_splenocyte_physiolog1.41164431
58MP0002233_abnormal_nose_morphology1.38581302
59MP0002132_abnormal_respiratory_system1.36861521
60MP0001835_abnormal_antigen_presentation1.36482244
61MP0000681_abnormal_thyroid_gland1.33188706
62MP0003635_abnormal_synaptic_transmissio1.33083041
63MP0005000_abnormal_immune_tolerance1.31398343
64MP0005501_abnormal_skin_physiology1.31143349
65MP0005375_adipose_tissue_phenotype1.30622754
66MP0005551_abnormal_eye_electrophysiolog1.29598781
67MP0003690_abnormal_glial_cell1.29303084
68MP0001486_abnormal_startle_reflex1.29185548
69MP0002098_abnormal_vibrissa_morphology1.23806496
70MP0000003_abnormal_adipose_tissue1.23382888
71MP0003763_abnormal_thymus_physiology1.21389469
72MP0000604_amyloidosis1.18248298
73MP0000685_abnormal_immune_system1.16606448
74MP0006035_abnormal_mitochondrial_morpho1.16019959
75MP0005535_abnormal_body_temperature1.15960766
76MP0002723_abnormal_immune_serum1.15374896
77MP0003787_abnormal_imprinting1.13798133
78MP0005670_abnormal_white_adipose1.13304070
79MP0002420_abnormal_adaptive_immunity1.13056354
80MP0008057_abnormal_DNA_replication1.10245635
81MP0001819_abnormal_immune_cell1.08909378
82MP0000049_abnormal_middle_ear1.08546217
83MP0009379_abnormal_foot_pigmentation1.05911925
84MP0003828_pulmonary_edema1.05039859
85MP0002063_abnormal_learning/memory/cond1.04054874
86MP0000762_abnormal_tongue_morphology1.03638559
87MP0001664_abnormal_digestion1.01924738
88MP0002452_abnormal_antigen_presenting1.01069348
89MP0000490_abnormal_crypts_of1.01055238
90MP0001501_abnormal_sleep_pattern1.00259639
91MP0001188_hyperpigmentation0.99228140
92MP0000751_myopathy0.98777595
93MP0005253_abnormal_eye_physiology0.98136056
94MP0001502_abnormal_circadian_rhythm0.96198551
95MP0000716_abnormal_immune_system0.95886796
96MP0003453_abnormal_keratinocyte_physiol0.95418090
97MP0002572_abnormal_emotion/affect_behav0.95317476
98MP0001849_ear_inflammation0.93813372
99MP0003121_genomic_imprinting0.92637975
100MP0005423_abnormal_somatic_nervous0.91717959
101MP0002419_abnormal_innate_immunity0.91582370
102MP0003075_altered_response_to0.91554075
103MP0001348_abnormal_lacrimal_gland0.88902671
104MP0002653_abnormal_ependyma_morphology0.88529564
105MP0002405_respiratory_system_inflammati0.87358668
106MP0002398_abnormal_bone_marrow0.87194772
107MP0003123_paternal_imprinting0.86529056
108MP0002090_abnormal_vision0.86354839
109MP0002970_abnormal_white_adipose0.86030279
110MP0001324_abnormal_eye_pigmentation0.85906466
111MP0002722_abnormal_immune_system0.84642082
112MP0001765_abnormal_ion_homeostasis0.82916665
113MP0005025_abnormal_response_to0.82373395
114MP0000689_abnormal_spleen_morphology0.82017483
115MP0003880_abnormal_central_pattern0.80962443
116MP0005166_decreased_susceptibility_to0.79024178
117MP0000955_abnormal_spinal_cord0.78172350
118MP0000013_abnormal_adipose_tissue0.78156483
119MP0005391_vision/eye_phenotype0.76393008
120MP0000920_abnormal_myelination0.76305014
121MP0000858_altered_metastatic_potential0.75476405
122MP0002932_abnormal_joint_morphology0.75172709
123MP0000477_abnormal_intestine_morphology0.73533815
124MP0006036_abnormal_mitochondrial_physio0.72726726
125MP0008770_decreased_survivor_rate0.72640264
126MP0003436_decreased_susceptibility_to0.71966935
127MP0003634_abnormal_glial_cell0.71625491
128MP0000703_abnormal_thymus_morphology0.71445783
129MP0002429_abnormal_blood_cell0.70663881
130MP0004859_abnormal_synaptic_plasticity0.70593347
131MP0005584_abnormal_enzyme/coenzyme_acti0.70290898
132MP0001663_abnormal_digestive_system0.70108673
133MP0009931_abnormal_skin_appearance0.69425168
134MP0010368_abnormal_lymphatic_system0.69386173
135MP0002272_abnormal_nervous_system0.69204092
136MP0004142_abnormal_muscle_tone0.69137778
137MP0009785_altered_susceptibility_to0.68502420
138MP0003950_abnormal_plasma_membrane0.67219595
139MP0008874_decreased_physiological_sensi0.66497639
140MP0000747_muscle_weakness0.66341278
141MP0002752_abnormal_somatic_nervous0.65332646
142MP0000383_abnormal_hair_follicle0.65295400
143MP0002092_abnormal_eye_morphology0.64747283
144MP0004947_skin_inflammation0.64551812
145MP0004085_abnormal_heartbeat0.64497611
146MP0001293_anophthalmia0.63934209
147MP0002064_seizures0.63790492
148MP0003045_fibrosis0.61455432
149MP0000749_muscle_degeneration0.59647775
150MP0004270_analgesia0.59305181
151MP0002751_abnormal_autonomic_nervous0.59074787
152MP0005195_abnormal_posterior_eye0.58706986
153MP0008872_abnormal_physiological_respon0.58685690
154MP0001970_abnormal_pain_threshold0.57371698
155MP0002148_abnormal_hypersensitivity_rea0.56608404
156MP0000631_abnormal_neuroendocrine_gland0.55069878
157MP0000377_abnormal_hair_follicle0.54302715
158MP0002735_abnormal_chemical_nociception0.52211727

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.89291111
2Hypochromic microcytic anemia (HP:0004840)5.17648022
3Hepatoblastoma (HP:0002884)4.57078988
4Ankle clonus (HP:0011448)4.04481303
5Rib fusion (HP:0000902)4.04350617
6J-shaped sella turcica (HP:0002680)4.03381666
7Abnormality of the lower motor neuron (HP:0002366)3.82307943
8Cheilitis (HP:0100825)3.73835822
9Obstructive sleep apnea (HP:0002870)3.61215736
10Hypoplasia of the fovea (HP:0007750)3.60759879
11Aplasia/Hypoplasia of the fovea (HP:0008060)3.60759879
12Supranuclear gaze palsy (HP:0000605)3.52514642
13Febrile seizures (HP:0002373)3.45852094
14Hyperinsulinemic hypoglycemia (HP:0000825)3.39682432
15Increased IgE level (HP:0003212)3.25119935
16Periauricular skin pits (HP:0100277)3.09161344
17Preauricular pit (HP:0004467)3.09161344
18Petechiae (HP:0000967)3.08993279
19Anomalous pulmonary venous return (HP:0010772)3.06537368
20Bifid tongue (HP:0010297)3.05718134
21Combined immunodeficiency (HP:0005387)3.05025295
22Lip pit (HP:0100267)3.01638693
23Epileptic encephalopathy (HP:0200134)2.99268266
24Hyperventilation (HP:0002883)2.97942633
25Multiple enchondromatosis (HP:0005701)2.97067668
26Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.95529791
27Eczematoid dermatitis (HP:0000976)2.95380087
28Partial duplication of thumb phalanx (HP:0009944)2.91047070
29Thin bony cortex (HP:0002753)2.90596499
30Myokymia (HP:0002411)2.89709314
31Nasolacrimal duct obstruction (HP:0000579)2.88267966
32Exercise-induced myalgia (HP:0003738)2.86431791
33Neuronal loss in central nervous system (HP:0002529)2.86413358
34Abnormality of the fovea (HP:0000493)2.85420697
35Neoplasm of striated muscle (HP:0009728)2.84489338
36Ependymoma (HP:0002888)2.82172139
37Intestinal fistula (HP:0100819)2.80173187
38Generalized hypotonia (HP:0001290)2.71971687
39Seborrheic dermatitis (HP:0001051)2.71519863
40Abnormality of the salivary glands (HP:0010286)2.71351840
41Reduced antithrombin III activity (HP:0001976)2.70102025
42Sensory axonal neuropathy (HP:0003390)2.68460049
43Myopathic facies (HP:0002058)2.67604936
44Visual hallucinations (HP:0002367)2.66293622
45Nasal polyposis (HP:0100582)2.62597095
46Neoplasm of the heart (HP:0100544)2.60433024
47Colitis (HP:0002583)2.60296645
48Reticulocytosis (HP:0001923)2.59651950
49Stridor (HP:0010307)2.59154749
50Dysostosis multiplex (HP:0000943)2.58183944
51Pendular nystagmus (HP:0012043)2.55489129
52Gastrointestinal inflammation (HP:0004386)2.49861340
53Increased cerebral lipofuscin (HP:0011813)2.48417290
54Abnormality of the pulmonary veins (HP:0011718)2.47717856
55Hemorrhage of the eye (HP:0011885)2.46686000
56Annular pancreas (HP:0001734)2.46416941
57Cellulitis (HP:0100658)2.45485335
58Distal lower limb amyotrophy (HP:0008944)2.44154011
59Broad face (HP:0000283)2.43543134
60Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.42961293
61Rectovaginal fistula (HP:0000143)2.42865446
62Rectal fistula (HP:0100590)2.42865446
63Amblyopia (HP:0000646)2.40245281
64Chromosomal breakage induced by crosslinking agents (HP:0003221)2.39602500
65Aplasia/Hypoplasia of the macula (HP:0008059)2.38898413
66Upper limb muscle weakness (HP:0003484)2.38528196
67Papilledema (HP:0001085)2.38465204
68Peripheral hypomyelination (HP:0007182)2.37961348
69Partial duplication of the phalanx of hand (HP:0009999)2.37201278
70Spinal canal stenosis (HP:0003416)2.36912174
71Elevated erythrocyte sedimentation rate (HP:0003565)2.35246592
72Amyotrophic lateral sclerosis (HP:0007354)2.35123526
73Nephroblastoma (Wilms tumor) (HP:0002667)2.34502540
74Skin pits (HP:0100276)2.34201072
75Fatigue (HP:0012378)2.33841456
76Prolonged bleeding time (HP:0003010)2.32580178
77Growth hormone excess (HP:0000845)2.32213787
78Abnormality of small intestinal villus morphology (HP:0011472)2.32033337
79Villous atrophy (HP:0011473)2.32033337
80Deformed sella turcica (HP:0002681)2.31375787
81Abnormality of the lacrimal duct (HP:0011481)2.31302701
82Neurofibrillary tangles (HP:0002185)2.31264943
83Increased neuronal autofluorescent lipopigment (HP:0002074)2.30229865
84Horizontal nystagmus (HP:0000666)2.26342530
85Centrally nucleated skeletal muscle fibers (HP:0003687)2.25377565
86Preauricular skin tag (HP:0000384)2.24131347
87Easy fatigability (HP:0003388)2.23938595
88Malnutrition (HP:0004395)2.23069077
89Difficulty climbing stairs (HP:0003551)2.23012306
90Ragged-red muscle fibers (HP:0003200)2.22666690
91Cerebral palsy (HP:0100021)2.22601246
92Rhabdomyosarcoma (HP:0002859)2.20977993
93Slow saccadic eye movements (HP:0000514)2.19868001
94Hemiparesis (HP:0001269)2.19727549
95Hypertensive crisis (HP:0100735)2.18112617
96Congenital stationary night blindness (HP:0007642)2.16823894
97Cerebral inclusion bodies (HP:0100314)2.15240205
98Testicular atrophy (HP:0000029)2.14049304
99Difficulty walking (HP:0002355)2.13038483
100Thoracic kyphosis (HP:0002942)2.12157092
101Hyperthyroidism (HP:0000836)2.11814866
102Distal upper limb amyotrophy (HP:0007149)2.10829689
103Upper limb amyotrophy (HP:0009129)2.10829689
104Urinary glycosaminoglycan excretion (HP:0003541)2.10788157
105Mucopolysacchariduria (HP:0008155)2.10788157
106Agammaglobulinemia (HP:0004432)2.10391741
107Abnormality of liposaccharide metabolism (HP:0010968)2.09783633
108Abnormality of glycosphingolipid metabolism (HP:0004343)2.09783633
109Abnormality of glycolipid metabolism (HP:0010969)2.09783633
110Inflammation of the large intestine (HP:0002037)2.08871327
111Neoplasm of the tracheobronchial system (HP:0100552)2.08104987
112Vaginal fistula (HP:0004320)2.07818500
113Aplasia/Hypoplasia affecting the retina (HP:0008061)2.07418505
114Systemic lupus erythematosus (HP:0002725)2.07119246
115Purpura (HP:0000979)2.05931391
116Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05555772
117Abnormality of polysaccharide metabolism (HP:0011012)2.05555772
118Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05555772
119Increased IgM level (HP:0003496)2.04368798
120Obstructive lung disease (HP:0006536)2.03950224
121Chronic obstructive pulmonary disease (HP:0006510)2.03950224
122Skin tags (HP:0010609)2.03627302
123Embryonal renal neoplasm (HP:0011794)2.03138532
124Large earlobe (HP:0009748)2.02967230
125Abnormality of the nasal mucosa (HP:0000433)2.02095868
126Abnormality of the thoracic spine (HP:0100711)2.01641994
127Truncus arteriosus (HP:0001660)2.00553913
128Gait imbalance (HP:0002141)1.99457876
129Restrictive lung disease (HP:0002091)1.98357605
130Loss of speech (HP:0002371)1.98054481
131Rapidly progressive (HP:0003678)1.97894393
132Hyperacusis (HP:0010780)1.97794434
133Congenital primary aphakia (HP:0007707)1.96293714
134Upper motor neuron abnormality (HP:0002127)1.95473706
135Tetraplegia (HP:0002445)1.95062589
136Tented upper lip vermilion (HP:0010804)1.93820868
137Chest pain (HP:0100749)1.92994202
138Neonatal onset (HP:0003623)1.91568933
139Spastic gait (HP:0002064)1.91563740
140Supernumerary nipples (HP:0002558)1.90382306
141Muscle stiffness (HP:0003552)1.89738241
142Abnormality of the astrocytes (HP:0100707)1.89476280
143Astrocytoma (HP:0009592)1.89476280
144Abnormality of the nasolacrimal system (HP:0000614)1.89476217
145Bulbar palsy (HP:0001283)1.89004910
146Dyschromatopsia (HP:0007641)1.88848464
147Abnormality of the pubic bones (HP:0003172)1.88721799
148Segmental peripheral demyelination/remyelination (HP:0003481)1.87876164
149Foot dorsiflexor weakness (HP:0009027)1.87013900
150Cerebral aneurysm (HP:0004944)1.86115816
151Broad foot (HP:0001769)1.85737161
152Gastrointestinal dysmotility (HP:0002579)1.85427671
153Distal lower limb muscle weakness (HP:0009053)1.84609333
154Bifid scrotum (HP:0000048)1.84464891
155Axonal loss (HP:0003447)1.83103359
156Pulmonary infiltrates (HP:0002113)1.82604088
157Atelectasis (HP:0100750)1.82410076
1583-Methylglutaconic aciduria (HP:0003535)1.81440169
159Protruding tongue (HP:0010808)1.80915226
160Spastic tetraparesis (HP:0001285)1.80576204
161Neurodegeneration (HP:0002180)1.80304545
162Hyperparathyroidism (HP:0000843)1.79867614
163Germ cell neoplasia (HP:0100728)1.79671984
164Gingivitis (HP:0000230)1.79516490
165Curly hair (HP:0002212)1.77847695
166Open mouth (HP:0000194)1.77622107
167Pili torti (HP:0003777)1.76177482
168Diminished motivation (HP:0000745)1.76176601
169Personality changes (HP:0000751)1.75477913
170Scrotal hypoplasia (HP:0000046)1.75367833
171Osteomalacia (HP:0002749)1.75015693
172Bowel incontinence (HP:0002607)1.74464092
173Nephrogenic diabetes insipidus (HP:0009806)1.73681840
174Vasculitis (HP:0002633)1.73424767
175Hypochromic anemia (HP:0001931)1.73069215
176Dementia (HP:0000726)1.73039764
177Broad distal phalanx of finger (HP:0009836)1.72670602
178Recurrent abscess formation (HP:0002722)1.72622207
179Cholecystitis (HP:0001082)1.72492265
180Abnormal gallbladder physiology (HP:0012438)1.72492265
181Abnormality of the musculature of the hand (HP:0001421)1.72434912
182Type I transferrin isoform profile (HP:0003642)1.71840082
183Achilles tendon contracture (HP:0001771)1.71436537
184Lymphangioma (HP:0100764)1.71146657
185Trismus (HP:0000211)1.71136989
186Fused cervical vertebrae (HP:0002949)1.70976670
187Abnormal hair laboratory examination (HP:0003328)1.70533196
188Hypercortisolism (HP:0001578)1.70513765
189Recurrent fungal infections (HP:0002841)1.69249290
190Interstitial pulmonary disease (HP:0006530)1.68989506
191Panhypogammaglobulinemia (HP:0003139)1.68743427
192Lower limb amyotrophy (HP:0007210)1.68172466
193Abnormality of the fingertips (HP:0001211)1.67559171
194Recurrent sinusitis (HP:0011108)1.67553985
195Meningitis (HP:0001287)1.66811761
196Chromsome breakage (HP:0040012)1.66681041

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.28704138
2TRIB34.57897133
3GRK54.34930339
4ERN14.24342675
5GRK63.98819307
6ADRBK23.36076222
7CSF1R2.93116918
8TGFBR22.83128256
9GRK12.72995891
10MAPK72.50413916
11SIK22.45213623
12GRK72.39640669
13WNK12.31971675
14MAP3K112.21305495
15EEF2K2.13017877
16TYRO32.12985824
17STK101.99646815
18SMG11.89798746
19MARK21.81482771
20MAP2K31.81152570
21MATK1.79624299
22SIK31.79280888
23TESK21.75871144
24CAMKK11.71795451
25PKN21.69724795
26TESK11.65484219
27NME21.63851637
28ITK1.62400664
29PRKD31.58568515
30HIPK21.52972429
31IRAK31.43226706
32CAMK41.43172315
33MAP4K11.41684292
34SIK11.29981913
35CSK1.29147202
36SCYL21.24778204
37MOS1.24663908
38KDR1.23652246
39MAP3K11.20471841
40TAOK11.20397595
41RIPK41.20252118
42TBK11.19093910
43MAP3K71.17127582
44INSRR1.17053693
45ICK1.16554347
46TXK1.14767143
47NTRK11.13692901
48FGFR31.02371360
49MAPK121.01577938
50MAP3K141.01238896
51MAP3K61.00245549
52PDPK10.98007726
53PRKG20.95634282
54ADRBK10.92421343
55RPS6KA20.92188612
56ARAF0.91212880
57MAP2K60.89037181
58PTK60.88640815
59MAP2K20.88320425
60KIT0.88201854
61MUSK0.87678712
62MAP3K130.85765558
63DAPK10.84580910
64PDK10.84493220
65MAPK110.83885345
66BLK0.81053033
67BMX0.80686650
68PIM20.80404547
69KSR20.79981143
70UHMK10.77526971
71SYK0.76860419
72MST1R0.76577893
73MST40.75791119
74PAK60.75135046
75PRKD20.75079979
76LCK0.74070610
77IKBKB0.73242673
78HCK0.72196840
79PRKCQ0.69859293
80TNIK0.69278080
81LRRK20.67401130
82RPS6KC10.66823635
83RPS6KL10.66823635
84TAOK20.66455728
85PRPF4B0.66246917
86EIF2AK20.66046409
87CDC42BPA0.65958770
88MAP3K30.60812908
89AKT20.60069202
90MAP3K100.59969814
91CDK190.59394271
92MAPKAPK30.58727742
93PRKCH0.58460662
94RET0.58340885
95IGF1R0.57668866
96YES10.57610587
97EPHA40.57227533
98IRAK20.55591691
99TNK20.55001922
100JAK30.53784187
101NTRK20.52438771
102JAK10.51669326
103DYRK1A0.50477703
104INSR0.50241365
105CAMK10.50157663
106NEK60.50060020
107TTK0.49075213
108MTOR0.48593398
109AKT30.48441093
110NTRK30.47831966
111TYK20.47643374
112RPS6KA60.47497253
113MAP2K40.45630491
114FES0.44276137
115MARK30.44143847
116PRKCI0.44015760
117PTK20.43522228
118ZAP700.43504036
119CDK70.43468538
120LYN0.41287891
121PRKD10.40544249
122IRAK40.40498914
123CDK40.39112836
124LMTK20.38985062
125JAK20.38918229
126BRD40.38606950
127CASK0.37012257
128PRKCD0.36749214
129IKBKE0.36207851
130MAPK40.36080461
131FYN0.34698720
132PKN10.34632440
133FGFR40.33133483
134FGR0.32365800
135EPHB10.30170413
136CHUK0.28840813
137DAPK20.28625012
138BTK0.28238175
139CHEK20.27304280
140ALK0.27109538
141RIPK10.26137126
142ABL10.24996947
143SRC0.24821585
144DYRK1B0.24705338
145PDGFRB0.24567917
146MAP3K20.24511563
147CDK50.22586910
148MAPK100.22165410
149PRKACA0.21895395
150CSNK1A10.20561409
151STK380.20117697

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.43067303
2Vitamin B6 metabolism_Homo sapiens_hsa007503.41989087
3Primary immunodeficiency_Homo sapiens_hsa053402.87307275
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.84144527
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.35149633
6Fructose and mannose metabolism_Homo sapiens_hsa000512.11025743
7T cell receptor signaling pathway_Homo sapiens_hsa046601.89732233
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.82854025
9Synaptic vesicle cycle_Homo sapiens_hsa047211.82066988
10B cell receptor signaling pathway_Homo sapiens_hsa046621.80997175
11Notch signaling pathway_Homo sapiens_hsa043301.72345291
12Other glycan degradation_Homo sapiens_hsa005111.70786928
13Sulfur relay system_Homo sapiens_hsa041221.66223822
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65430867
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.59969283
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.58466470
17GABAergic synapse_Homo sapiens_hsa047271.47520110
18Taste transduction_Homo sapiens_hsa047421.46828655
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.45127829
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42658862
21Arachidonic acid metabolism_Homo sapiens_hsa005901.40931583
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38958394
23Glutamatergic synapse_Homo sapiens_hsa047241.38501703
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36114167
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.35876650
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.35362854
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.35148728
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32874187
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32667715
30Hematopoietic cell lineage_Homo sapiens_hsa046401.32238731
31Nicotine addiction_Homo sapiens_hsa050331.31056960
32Inositol phosphate metabolism_Homo sapiens_hsa005621.30755699
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29104706
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27038087
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22083656
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21232879
37Phospholipase D signaling pathway_Homo sapiens_hsa040721.20460550
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.18779701
39Leishmaniasis_Homo sapiens_hsa051401.14230375
40Morphine addiction_Homo sapiens_hsa050321.13457797
41Chronic myeloid leukemia_Homo sapiens_hsa052201.12078486
42African trypanosomiasis_Homo sapiens_hsa051431.12070710
43Serotonergic synapse_Homo sapiens_hsa047261.11596492
44Pentose phosphate pathway_Homo sapiens_hsa000301.10489513
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06133410
46Linoleic acid metabolism_Homo sapiens_hsa005911.05811364
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04611303
48Acute myeloid leukemia_Homo sapiens_hsa052211.02859939
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00659080
50Adipocytokine signaling pathway_Homo sapiens_hsa049201.00412279
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98492258
52Amphetamine addiction_Homo sapiens_hsa050310.97843381
53Choline metabolism in cancer_Homo sapiens_hsa052310.96270608
54Ether lipid metabolism_Homo sapiens_hsa005650.95760349
55Endocytosis_Homo sapiens_hsa041440.95752410
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95628514
57ErbB signaling pathway_Homo sapiens_hsa040120.95605472
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95577234
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95509639
60Rap1 signaling pathway_Homo sapiens_hsa040150.94292789
61AMPK signaling pathway_Homo sapiens_hsa041520.93916429
62Glioma_Homo sapiens_hsa052140.93865892
63Galactose metabolism_Homo sapiens_hsa000520.92775360
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91352222
65Lysosome_Homo sapiens_hsa041420.90873391
66Insulin signaling pathway_Homo sapiens_hsa049100.90627096
67Estrogen signaling pathway_Homo sapiens_hsa049150.89602961
68Platelet activation_Homo sapiens_hsa046110.88059841
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.85964848
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85936219
71Olfactory transduction_Homo sapiens_hsa047400.84377875
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83975951
73Calcium signaling pathway_Homo sapiens_hsa040200.83743618
74Osteoclast differentiation_Homo sapiens_hsa043800.83533279
75* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82768652
76ABC transporters_Homo sapiens_hsa020100.79764668
77cAMP signaling pathway_Homo sapiens_hsa040240.79286546
78Pancreatic cancer_Homo sapiens_hsa052120.78753820
79Tuberculosis_Homo sapiens_hsa051520.78688188
80Arginine biosynthesis_Homo sapiens_hsa002200.78267874
81Cocaine addiction_Homo sapiens_hsa050300.76155614
82Chemokine signaling pathway_Homo sapiens_hsa040620.75290242
83Prion diseases_Homo sapiens_hsa050200.74932269
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73792764
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.73646853
86Insulin resistance_Homo sapiens_hsa049310.73425226
87Gastric acid secretion_Homo sapiens_hsa049710.72429860
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72155792
89Ovarian steroidogenesis_Homo sapiens_hsa049130.72044977
90Phototransduction_Homo sapiens_hsa047440.71530109
91Circadian entrainment_Homo sapiens_hsa047130.71361611
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70656178
93MAPK signaling pathway_Homo sapiens_hsa040100.69788360
94Prolactin signaling pathway_Homo sapiens_hsa049170.69672213
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.69318493
96Autoimmune thyroid disease_Homo sapiens_hsa053200.68934205
97VEGF signaling pathway_Homo sapiens_hsa043700.68076457
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.68067921
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67069401
100Endometrial cancer_Homo sapiens_hsa052130.66579721
101Ras signaling pathway_Homo sapiens_hsa040140.66293789
102Axon guidance_Homo sapiens_hsa043600.66209449
103Chemical carcinogenesis_Homo sapiens_hsa052040.65751972
104Non-small cell lung cancer_Homo sapiens_hsa052230.65365913
105Bile secretion_Homo sapiens_hsa049760.64792006
106TNF signaling pathway_Homo sapiens_hsa046680.64604497
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.64363811
108Thyroid cancer_Homo sapiens_hsa052160.64073095
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62975375
110Renin secretion_Homo sapiens_hsa049240.62947009
111Long-term depression_Homo sapiens_hsa047300.62138554
112Biosynthesis of amino acids_Homo sapiens_hsa012300.61901544
113Oxytocin signaling pathway_Homo sapiens_hsa049210.61721115
114Measles_Homo sapiens_hsa051620.61597731
115Salivary secretion_Homo sapiens_hsa049700.61010266
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60569141
117Vibrio cholerae infection_Homo sapiens_hsa051100.60230842
118Long-term potentiation_Homo sapiens_hsa047200.59057632
119Dopaminergic synapse_Homo sapiens_hsa047280.57621835
120Renin-angiotensin system_Homo sapiens_hsa046140.57590472
121Insulin secretion_Homo sapiens_hsa049110.56993592
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56258338
123Vitamin digestion and absorption_Homo sapiens_hsa049770.55861425
124Graft-versus-host disease_Homo sapiens_hsa053320.55426289
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.55286076
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55095105
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.55023493
128Base excision repair_Homo sapiens_hsa034100.54802061
129Dilated cardiomyopathy_Homo sapiens_hsa054140.54252219
130Hepatitis B_Homo sapiens_hsa051610.53819971
131Bladder cancer_Homo sapiens_hsa052190.53654079
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.53547202
133Salmonella infection_Homo sapiens_hsa051320.53464558
134Lysine degradation_Homo sapiens_hsa003100.53030429
135Glucagon signaling pathway_Homo sapiens_hsa049220.52852465
136GnRH signaling pathway_Homo sapiens_hsa049120.52560977
137Herpes simplex infection_Homo sapiens_hsa051680.52272288
138Hepatitis C_Homo sapiens_hsa051600.51746321
139* mTOR signaling pathway_Homo sapiens_hsa041500.51709738
140Type II diabetes mellitus_Homo sapiens_hsa049300.50961949
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50472774
142Toxoplasmosis_Homo sapiens_hsa051450.50107046
143Apoptosis_Homo sapiens_hsa042100.49931994
144Allograft rejection_Homo sapiens_hsa053300.49908801
145Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47278122
146Cholinergic synapse_Homo sapiens_hsa047250.44157212
147Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43655989
148Steroid hormone biosynthesis_Homo sapiens_hsa001400.43588752
149Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42185298
150Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41069797
151Neurotrophin signaling pathway_Homo sapiens_hsa047220.39907635
152Influenza A_Homo sapiens_hsa051640.39500785

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