ULK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1serine family amino acid catabolic process (GO:0009071)5.17869775
2glycine metabolic process (GO:0006544)4.69488665
3negative regulation of erythrocyte differentiation (GO:0045647)4.60880373
4regulation of cholesterol homeostasis (GO:2000188)4.07331440
5pre-miRNA processing (GO:0031054)3.87414679
6cysteine metabolic process (GO:0006534)3.78416386
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.76914450
8L-phenylalanine metabolic process (GO:0006558)3.76914450
9serine family amino acid metabolic process (GO:0009069)3.75595412
10kynurenine metabolic process (GO:0070189)3.71428921
11lysine metabolic process (GO:0006553)3.70734030
12lysine catabolic process (GO:0006554)3.70734030
13folic acid metabolic process (GO:0046655)3.70644495
14sulfur amino acid catabolic process (GO:0000098)3.70638072
15mannose metabolic process (GO:0006013)3.69155791
16negative regulation of fatty acid biosynthetic process (GO:0045717)3.68655405
17L-phenylalanine catabolic process (GO:0006559)3.63838720
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.63838720
19carnitine shuttle (GO:0006853)3.63527315
202-oxoglutarate metabolic process (GO:0006103)3.54250488
21regulation of ARF GTPase activity (GO:0032312)3.53292231
22anterior/posterior axis specification, embryo (GO:0008595)3.52862799
23amino-acid betaine metabolic process (GO:0006577)3.51845649
24fatty acid transmembrane transport (GO:1902001)3.46389484
25regulation of ARF protein signal transduction (GO:0032012)3.43862469
26glyoxylate metabolic process (GO:0046487)3.35345713
27negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.31102785
28aromatic amino acid family catabolic process (GO:0009074)3.28254726
29homocysteine metabolic process (GO:0050667)3.26347773
30dicarboxylic acid biosynthetic process (GO:0043650)3.24174393
31biotin metabolic process (GO:0006768)3.23270428
32regulation of hippo signaling (GO:0035330)3.20746762
33paraxial mesoderm development (GO:0048339)3.16251534
34adherens junction assembly (GO:0034333)3.13632003
35cytoskeletal anchoring at plasma membrane (GO:0007016)3.12491098
36negative regulation of cell killing (GO:0031342)3.11924716
37negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.11924716
38cell-cell junction maintenance (GO:0045217)3.11477563
39intestinal epithelial cell development (GO:0060576)3.11059629
40positive regulation of Cdc42 GTPase activity (GO:0043089)3.10828921
41modulation by symbiont of host defense response (GO:0052031)3.10699956
42modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.10699956
43modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.10699956
44positive regulation by organism of defense response of other organism involved in symbiotic interact3.10699956
45modulation by symbiont of host immune response (GO:0052553)3.10699956
46positive regulation by symbiont of host defense response (GO:0052509)3.10699956
47urea metabolic process (GO:0019627)3.10131707
48urea cycle (GO:0000050)3.10131707
49tryptophan catabolic process (GO:0006569)3.08835903
50indole-containing compound catabolic process (GO:0042436)3.08835903
51indolalkylamine catabolic process (GO:0046218)3.08835903
52negative regulation of fibrinolysis (GO:0051918)3.08543286
53alpha-amino acid catabolic process (GO:1901606)3.08110456
54regulation of translational termination (GO:0006449)3.07813994
55focal adhesion assembly (GO:0048041)3.06501170
56cell-substrate adherens junction assembly (GO:0007045)3.06501170
57triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.02657334
58alpha-linolenic acid metabolic process (GO:0036109)3.00979382
59regulation of protein activation cascade (GO:2000257)2.99220526
60detection of bacterium (GO:0016045)2.97980213
61signal complex assembly (GO:0007172)2.96987281
62apoptotic process involved in morphogenesis (GO:0060561)2.96753380
63detection of other organism (GO:0098543)2.96685329
64cellular amino acid catabolic process (GO:0009063)2.94829481
65semaphorin-plexin signaling pathway (GO:0071526)2.94728479
66positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.94182985
67fatty acid homeostasis (GO:0055089)2.93546701
68response to muramyl dipeptide (GO:0032495)2.93459460
69serine family amino acid biosynthetic process (GO:0009070)2.91016741
70mitotic G1 DNA damage checkpoint (GO:0031571)2.90524387
71maternal placenta development (GO:0001893)2.90210138
723-UTR-mediated mRNA stabilization (GO:0070935)2.89639973
73positive regulation of fatty acid beta-oxidation (GO:0032000)2.87862258
74tryptophan metabolic process (GO:0006568)2.87166867
75negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.86905224
76response to laminar fluid shear stress (GO:0034616)2.85276971
77positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.83548180
78histone H3-K36 demethylation (GO:0070544)2.82483266
79heme transport (GO:0015886)2.80912173
80regulation of complement activation (GO:0030449)2.80245503
81fructose metabolic process (GO:0006000)2.79754473
82NADH metabolic process (GO:0006734)2.79531897
83negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.78618616
84planar cell polarity pathway involved in neural tube closure (GO:0090179)2.78132970
85regulation of bile acid biosynthetic process (GO:0070857)2.77875799
86vitamin transmembrane transport (GO:0035461)2.77669267
87regulation of fatty acid beta-oxidation (GO:0031998)2.77298959
88negative regulation of fatty acid metabolic process (GO:0045922)2.76505597
89cellular modified amino acid catabolic process (GO:0042219)2.76401203
90aspartate family amino acid catabolic process (GO:0009068)2.76349029
91insulin-like growth factor receptor signaling pathway (GO:0048009)2.76237275
92peptidyl-glutamic acid carboxylation (GO:0017187)2.76023214
93protein carboxylation (GO:0018214)2.76023214
94purine nucleobase biosynthetic process (GO:0009113)2.75720343
95regulation of NFAT protein import into nucleus (GO:0051532)2.75124499
96glutamate metabolic process (GO:0006536)2.74134706
97trophectodermal cell differentiation (GO:0001829)2.74104649
98acetyl-CoA metabolic process (GO:0006084)2.73641019
99epithelial cell differentiation involved in prostate gland development (GO:0060742)2.73104491
100negative regulation of cell size (GO:0045792)2.72764774
101nitrogen cycle metabolic process (GO:0071941)2.72432454
102positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.71973827
103regulation of posttranscriptional gene silencing (GO:0060147)2.71062179
104regulation of gene silencing by miRNA (GO:0060964)2.71062179
105regulation of gene silencing by RNA (GO:0060966)2.71062179
106leukocyte aggregation (GO:0070486)2.70836199
107response to peptidoglycan (GO:0032494)2.69879101
108mitotic G1/S transition checkpoint (GO:0044819)2.69510647
109regulation of fibrinolysis (GO:0051917)2.69023359
110positive regulation of histone deacetylation (GO:0031065)2.68684178
111regulation of fatty acid biosynthetic process (GO:0042304)2.67803520
112embryonic placenta development (GO:0001892)2.67732792
113acylglycerol homeostasis (GO:0055090)2.66590342
114triglyceride homeostasis (GO:0070328)2.66590342
115negative regulation of potassium ion transmembrane transport (GO:1901380)2.66490912
116atrioventricular valve morphogenesis (GO:0003181)2.66315426
117positive regulation of SMAD protein import into nucleus (GO:0060391)2.65942984
118protein localization to endosome (GO:0036010)2.65550858
119regulation of RNA export from nucleus (GO:0046831)2.65092464
120negative regulation of histone methylation (GO:0031061)2.64934205
121positive regulation of receptor recycling (GO:0001921)2.63599801
122labyrinthine layer development (GO:0060711)2.62595802
123bile acid biosynthetic process (GO:0006699)2.62558607
124negative regulation of glial cell proliferation (GO:0060253)2.62503411
125peptidyl-tyrosine autophosphorylation (GO:0038083)2.62121030
126complement activation, alternative pathway (GO:0006957)2.61951748
127protein targeting to plasma membrane (GO:0072661)2.61880014
128heterochromatin organization (GO:0070828)2.60664355
129activation of Rac GTPase activity (GO:0032863)2.59915523
130aromatic amino acid family metabolic process (GO:0009072)2.58819662
131nucleobase biosynthetic process (GO:0046112)2.58675397
132histone H2A monoubiquitination (GO:0035518)2.58506123
133embryonic process involved in female pregnancy (GO:0060136)2.58308468
134histone H3-K9 demethylation (GO:0033169)2.57912160
135fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.57610183
136G1 DNA damage checkpoint (GO:0044783)2.57133959
137carnitine metabolic process (GO:0009437)2.56939356
138intracellular estrogen receptor signaling pathway (GO:0030520)2.56418947
139positive regulation of Rap GTPase activity (GO:0032854)2.55957939
140negative regulation of sterol transport (GO:0032372)2.55740138
141negative regulation of cholesterol transport (GO:0032375)2.55740138
142histone H4-K12 acetylation (GO:0043983)2.55705956
143stress fiber assembly (GO:0043149)2.55396561
144regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.54469553
145detection of external biotic stimulus (GO:0098581)2.54336726
146regulation of T-helper 2 cell differentiation (GO:0045628)2.54263705
147bile acid metabolic process (GO:0008206)2.54031031
148histone H4-K8 acetylation (GO:0043982)2.53442696
149histone H4-K5 acetylation (GO:0043981)2.53442696
150ventricular cardiac muscle cell action potential (GO:0086005)2.53387621
151determination of adult lifespan (GO:0008340)2.52904962
152negative regulation of fatty acid transport (GO:2000192)2.52401121
153carnitine transmembrane transport (GO:1902603)2.52294175
154nuclear pore organization (GO:0006999)2.52283221
155regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.51695315
156regulation of regulated secretory pathway (GO:1903305)2.50051226
157negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.49051934
158regulation of early endosome to late endosome transport (GO:2000641)2.48026797
159modulation by virus of host process (GO:0019054)2.44535470
160activation of JUN kinase activity (GO:0007257)2.42812331
161regulation of chromatin binding (GO:0035561)2.42320722
162regulation of leukocyte degranulation (GO:0043300)2.42144932
163negative regulation of toll-like receptor signaling pathway (GO:0034122)2.41256083
164histone lysine demethylation (GO:0070076)2.40958383
165positive regulation of blood vessel endothelial cell migration (GO:0043536)2.40594078
166thymic T cell selection (GO:0045061)2.39622219
167macrophage activation involved in immune response (GO:0002281)2.38800961
168synaptic vesicle docking involved in exocytosis (GO:0016081)2.38418072
169regulation of histone H3-K27 methylation (GO:0061085)2.38246740
170modulation by symbiont of host cellular process (GO:0044068)2.37582335
171positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.37229767
172histone H4 deacetylation (GO:0070933)2.35714274
173positive regulation of CREB transcription factor activity (GO:0032793)2.34444903
174cell junction maintenance (GO:0034331)2.33566791
175cell-substrate junction assembly (GO:0007044)2.33214341
176detection of molecule of bacterial origin (GO:0032490)2.31827376
177negative regulation of myotube differentiation (GO:0010832)2.31521063
178glucose 6-phosphate metabolic process (GO:0051156)2.31245053
179regulation of phosphatidylinositol 3-kinase activity (GO:0043551)2.30550019
180G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.30129330
181regulation of lipid kinase activity (GO:0043550)2.28765265
182negative regulation of cAMP-mediated signaling (GO:0043951)2.28258467
183antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.27690186
184antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.27172233
185histone demethylation (GO:0016577)2.26508807
186positive regulation of protein dephosphorylation (GO:0035307)2.26352368
187positive regulation of synapse maturation (GO:0090129)2.25764056
188detection of biotic stimulus (GO:0009595)2.24644471
189cellular response to virus (GO:0098586)2.24218674
190regulation of myeloid leukocyte mediated immunity (GO:0002886)2.23983129
191germinal center formation (GO:0002467)2.23152975
192modulation by virus of host morphology or physiology (GO:0019048)2.23033324
193basement membrane organization (GO:0071711)2.20867284
194positive thymic T cell selection (GO:0045059)2.19002383
195regulation of endothelial cell chemotaxis (GO:2001026)2.18971428
196negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.18728558
197response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.14612650
198response to host defenses (GO:0052200)2.14612650

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.36761309
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.22386376
3ZNF263_19887448_ChIP-Seq_K562_Human3.10582037
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.03404170
5E2F7_22180533_ChIP-Seq_HELA_Human2.87144511
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.80774721
7* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.78257386
8* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.76530128
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.71323074
10VDR_21846776_ChIP-Seq_THP-1_Human2.71232088
11* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.58166999
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.56403101
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.56403101
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.56403101
15STAT3_1855785_ChIP-Seq_MESCs_Mouse2.46689661
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.44495689
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.41918778
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.36431038
19* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.33708666
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.33237015
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.22543661
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.11499276
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.08558873
24SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.08198932
25* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.07395859
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.96122697
27NANOG_18555785_ChIP-Seq_MESCs_Mouse1.93958102
28SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.91828684
29* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.85465307
30ESR1_15608294_ChIP-ChIP_MCF-7_Human1.84919065
31* KDM2B_26808549_Chip-Seq_JURKAT_Human1.84618800
32* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.82812748
33ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.82050359
34MYC_22102868_ChIP-Seq_BL_Human1.76202429
35* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.75424948
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73168329
37POU5F1_16518401_ChIP-PET_MESCs_Mouse1.70187841
38VDR_24763502_ChIP-Seq_THP-1_Human1.69681491
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67677991
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.63832557
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63420854
42SMC4_20622854_ChIP-Seq_HELA_Human1.62916197
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.62642789
44CTCF_27219007_Chip-Seq_ERYTHROID_Human1.60180269
45* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.58387063
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55955317
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.55770440
48* NANOG_21062744_ChIP-ChIP_HESCs_Human1.55582700
49* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.54596724
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53365280
51* SA1_27219007_Chip-Seq_ERYTHROID_Human1.52975935
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.49453700
53DROSHA_22980978_ChIP-Seq_HELA_Human1.48435931
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48395309
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48080608
56MAF_26560356_Chip-Seq_TH1_Human1.46854900
57* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.45895820
58CLOCK_20551151_ChIP-Seq_293T_Human1.44959894
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43656039
60ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42233228
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40369715
62* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.40200463
63KDM2B_26808549_Chip-Seq_DND41_Human1.40135412
64TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40128050
65* RUNX1_27514584_Chip-Seq_MCF-7_Human1.38743000
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38206849
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.37762600
68MYC_18555785_ChIP-Seq_MESCs_Mouse1.37285264
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36206230
70KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36069278
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35617294
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.35394729
73* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.34820217
74* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.34431553
75CTCF_27219007_Chip-Seq_Bcells_Human1.34402830
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34264728
77RACK7_27058665_Chip-Seq_MCF-7_Human1.34152479
78* UTX_26944678_Chip-Seq_JUKART_Human1.33778415
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.33147546
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.31768623
81ATF3_27146783_Chip-Seq_COLON_Human1.30277583
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30228064
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30224704
84SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29476384
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29138516
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28754193
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28559231
88* MAF_26560356_Chip-Seq_TH2_Human1.28545242
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26462053
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26451262
91* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.26053527
92* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.25324521
93LXR_22292898_ChIP-Seq_THP-1_Human1.24478628
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24355444
95KDM2B_26808549_Chip-Seq_K562_Human1.22672283
96* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.22604948
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.21017279
98* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.20976068
99* CREB1_26743006_Chip-Seq_LNCaP_Human1.20947119
100SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19844703
101* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18197413
102ELK3_25401928_ChIP-Seq_HUVEC_Human1.16552218
103CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15528658
104BCOR_27268052_Chip-Seq_Bcells_Human1.15493960
105RARB_27405468_Chip-Seq_BRAIN_Mouse1.14977603
106THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14185303
107* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13558886
108* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13517547
109* TCF7_22412390_ChIP-Seq_EML_Mouse1.13012447
110SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12466132
111KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12425969
112* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12188405
113P68_20966046_ChIP-Seq_HELA_Human1.11739357
114MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.11733150
115RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10707915
116RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10630033
117KAP1_27257070_Chip-Seq_ESCs_Mouse1.09812043
118* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08453535
119SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08426169
120KDM5A_27292631_Chip-Seq_BREAST_Human1.08160085
121GATA1_19941826_ChIP-Seq_K562_Human1.07201052
122TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.07143335
123SPI1_23127762_ChIP-Seq_K562_Human1.07101637
124EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06887716
125MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06244565
126ERG_21242973_ChIP-ChIP_JURKAT_Human1.05938083
127NCOR1_26117541_ChIP-Seq_K562_Human1.05883887
128TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05855353
129PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.05646924
130* NANOG_16518401_ChIP-PET_MESCs_Mouse1.05448903
131ELF1_20517297_ChIP-Seq_JURKAT_Human1.04362480
132DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04189502
133POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03005466
134FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02593104
135* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02524154
136* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02471882
137GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01358315
138STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01056909
139MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00909417
140BCL6_27268052_Chip-Seq_Bcells_Human1.00646623
141AR_21909140_ChIP-Seq_LNCAP_Human1.00388432
142* TP63_22573176_ChIP-Seq_HFKS_Human0.98652809
143OCT4_19829295_ChIP-Seq_ESCs_Human0.97758293
144PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97563564
145SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96832110
146SCL_19346495_ChIP-Seq_HPC-7_Human0.96564131
147TET1_21490601_ChIP-Seq_MESCs_Mouse0.96156651
148SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95194106
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.94716138
150* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94707396
151TP53_22127205_ChIP-Seq_IMR90_Human0.92958428
152* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92862183
153CTCF_21964334_ChIP-Seq_BJAB-B_Human0.92665535
154* STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.92419000
155DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90277756
156MYC_18358816_ChIP-ChIP_MESCs_Mouse0.89046373
157ESR1_21235772_ChIP-Seq_MCF-7_Human0.89035464
158* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88577515
159CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88204544

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005085_abnormal_gallbladder_physiolo3.77399617
2MP0002139_abnormal_hepatobiliary_system3.76755669
3MP0005365_abnormal_bile_salt3.66677956
4MP0005360_urolithiasis3.63386197
5MP0003806_abnormal_nucleotide_metabolis3.45837615
6MP0003705_abnormal_hypodermis_morpholog3.44050211
7MP0003436_decreased_susceptibility_to2.76280703
8MP0003172_abnormal_lysosome_physiology2.64541438
9MP0009840_abnormal_foam_cell2.63967859
10MP0005409_darkened_coat_color2.51912711
11MP0004859_abnormal_synaptic_plasticity2.37917315
12MP0003303_peritoneal_inflammation2.25673135
13MP0002653_abnormal_ependyma_morphology2.23009117
14MP0002249_abnormal_larynx_morphology2.20114078
15MP0002837_dystrophic_cardiac_calcinosis2.17996433
16MP0003111_abnormal_nucleus_morphology2.17124268
17MP0010329_abnormal_lipoprotein_level2.14166309
18MP0005058_abnormal_lysosome_morphology2.06286435
19MP0004381_abnormal_hair_follicle2.05301450
20MP0003646_muscle_fatigue1.96511786
21MP0005083_abnormal_biliary_tract1.95981276
22MP0004510_myositis1.95740886
23MP0008875_abnormal_xenobiotic_pharmacok1.90151320
24MP0004084_abnormal_cardiac_muscle1.86822330
25MP0002269_muscular_atrophy1.84584781
26MP0001348_abnormal_lacrimal_gland1.82348100
27MP0010352_gastrointestinal_tract_polyps1.82164281
28* MP0008260_abnormal_autophagy1.75587407
29MP0004957_abnormal_blastocyst_morpholog1.74284769
30MP0003252_abnormal_bile_duct1.73589944
31MP0003879_abnormal_hair_cell1.69912599
32MP0003878_abnormal_ear_physiology1.68503775
33MP0005377_hearing/vestibular/ear_phenot1.68503775
34MP0000678_abnormal_parathyroid_gland1.67984025
35MP0003693_abnormal_embryo_hatching1.67969186
36MP0005076_abnormal_cell_differentiation1.65369222
37MP0003453_abnormal_keratinocyte_physiol1.65268370
38MP0004130_abnormal_muscle_cell1.65198862
39MP0005332_abnormal_amino_acid1.63311246
40MP0005380_embryogenesis_phenotype1.61402368
41MP0001672_abnormal_embryogenesis/_devel1.61402368
42MP0001730_embryonic_growth_arrest1.59966954
43MP0008961_abnormal_basal_metabolism1.57897621
44MP0004947_skin_inflammation1.57842273
45MP0004185_abnormal_adipocyte_glucose1.54610377
46MP0003984_embryonic_growth_retardation1.51799638
47MP0002088_abnormal_embryonic_growth/wei1.51720685
48MP0000609_abnormal_liver_physiology1.50579836
49MP0005666_abnormal_adipose_tissue1.50293837
50MP0005670_abnormal_white_adipose1.49562184
51MP0001849_ear_inflammation1.48386028
52MP0000751_myopathy1.45862938
53MP0004233_abnormal_muscle_weight1.44822852
54MP0003300_gastrointestinal_ulcer1.44374293
55MP0001958_emphysema1.44324080
56MP0003329_amyloid_beta_deposits1.41473155
57MP0002086_abnormal_extraembryonic_tissu1.41250403
58MP0005330_cardiomyopathy1.40749006
59MP0003077_abnormal_cell_cycle1.40727174
60MP0003119_abnormal_digestive_system1.40681211
61MP0000750_abnormal_muscle_regeneration1.40393807
62MP0003567_abnormal_fetal_cardiomyocyte1.39388961
63MP0009278_abnormal_bone_marrow1.38183803
64MP0002084_abnormal_developmental_patter1.36912621
65MP0004019_abnormal_vitamin_homeostasis1.31656911
66MP0009672_abnormal_birth_weight1.30379543
67MP0004087_abnormal_muscle_fiber1.29587527
68MP0003724_increased_susceptibility_to1.27184665
69MP0004197_abnormal_fetal_growth/weight/1.26972389
70MP0003221_abnormal_cardiomyocyte_apopto1.26964476
71MP0005423_abnormal_somatic_nervous1.26734406
72MP0002118_abnormal_lipid_homeostasis1.26488738
73MP0003279_aneurysm1.25122159
74MP0005319_abnormal_enzyme/_coenzyme1.24694185
75MP0010630_abnormal_cardiac_muscle1.23803089
76MP0004264_abnormal_extraembryonic_tissu1.21699196
77MP0008057_abnormal_DNA_replication1.21154999
78MP0002089_abnormal_postnatal_growth/wei1.20694988
79MP0000350_abnormal_cell_proliferation1.20232650
80MP0002085_abnormal_embryonic_tissue1.20179076
81MP0003828_pulmonary_edema1.19064122
82MP0000747_muscle_weakness1.17949444
83MP0001697_abnormal_embryo_size1.17718362
84MP0003091_abnormal_cell_migration1.17314729
85MP0003191_abnormal_cellular_cholesterol1.17075488
86MP0001533_abnormal_skeleton_physiology1.16626748
87MP0010094_abnormal_chromosome_stability1.14438102
88MP0009053_abnormal_anal_canal1.12738275
89MP0003183_abnormal_peptide_metabolism1.12657072
90MP0002419_abnormal_innate_immunity1.12388134
91MP0004885_abnormal_endolymph1.11591254
92MP0002080_prenatal_lethality1.10131787
93MP0005266_abnormal_metabolism1.06388725
94MP0004215_abnormal_myocardial_fiber1.05942317
95MP0000767_abnormal_smooth_muscle1.04793244
96MP0003718_maternal_effect1.04652356
97MP0003656_abnormal_erythrocyte_physiolo1.04578461
98MP0000858_altered_metastatic_potential1.02383760
99MP0003075_altered_response_to1.02257240
100MP0006138_congestive_heart_failure1.02159196
101MP0002998_abnormal_bone_remodeling1.01841117
102MP0005501_abnormal_skin_physiology1.01102462
103MP0001666_abnormal_nutrient_absorption1.00055216
104MP0002127_abnormal_cardiovascular_syste0.99129946
105MP0008438_abnormal_cutaneous_collagen0.99063201
106MP0009931_abnormal_skin_appearance0.98836214
107MP0008569_lethality_at_weaning0.98509026
108MP0005025_abnormal_response_to0.98414857
109MP0002106_abnormal_muscle_physiology0.98262884
110MP0004036_abnormal_muscle_relaxation0.96182872
111MP0001545_abnormal_hematopoietic_system0.96090191
112MP0005397_hematopoietic_system_phenotyp0.96090191
113MP0002822_catalepsy0.95710829
114MP0003890_abnormal_embryonic-extraembry0.95664390
115MP0002796_impaired_skin_barrier0.94434571
116MP0003137_abnormal_impulse_conducting0.92878377
117MP0005451_abnormal_body_composition0.92322914
118MP0005375_adipose_tissue_phenotype0.91857626
119MP0004145_abnormal_muscle_electrophysio0.91648808
120MP0010234_abnormal_vibrissa_follicle0.91549879
121MP0005187_abnormal_penis_morphology0.89304140
122MP0003690_abnormal_glial_cell0.88649825
123MP0001851_eye_inflammation0.88432854
124MP0010030_abnormal_orbit_morphology0.88067600
125MP0000733_abnormal_muscle_development0.87153064
126MP0000003_abnormal_adipose_tissue0.86811614
127MP0008874_decreased_physiological_sensi0.86808233
128MP0003566_abnormal_cell_adhesion0.86525035
129MP0009703_decreased_birth_body0.86183113
130MP0005385_cardiovascular_system_phenoty0.85382169
131MP0001544_abnormal_cardiovascular_syste0.85382169
132MP0008775_abnormal_heart_ventricle0.84700821
133MP0003115_abnormal_respiratory_system0.84535381
134MP0004858_abnormal_nervous_system0.84370409
135MP0000579_abnormal_nail_morphology0.84339932
136MP0000759_abnormal_skeletal_muscle0.83966174
137MP0003123_paternal_imprinting0.83934036
138MP0002332_abnormal_exercise_endurance0.83274868
139MP0002060_abnormal_skin_morphology0.82922581
140MP0000598_abnormal_liver_morphology0.82836498
141MP0002396_abnormal_hematopoietic_system0.80773626
142MP0002254_reproductive_system_inflammat0.80181091
143MP0008770_decreased_survivor_rate0.78403339
144MP0006036_abnormal_mitochondrial_physio0.78354184
145MP0000266_abnormal_heart_morphology0.78263508
146MP0000685_abnormal_immune_system0.75946969
147MP0005369_muscle_phenotype0.75612986
148MP0005248_abnormal_Harderian_gland0.74995409
149MP0005390_skeleton_phenotype0.74771417
150MP0003763_abnormal_thymus_physiology0.74179197
151MP0002877_abnormal_melanocyte_morpholog0.73898353
152MP0003635_abnormal_synaptic_transmissio0.73250161
153MP0003283_abnormal_digestive_organ0.72987304
154MP0010307_abnormal_tumor_latency0.72741177
155MP0004133_heterotaxia0.70862244
156MP0000703_abnormal_thymus_morphology0.69795350
157MP0000462_abnormal_digestive_system0.69171205
158MP0004270_analgesia0.68317459
159MP0005023_abnormal_wound_healing0.67606325
160MP0002098_abnormal_vibrissa_morphology0.67482377
161MP0003866_abnormal_defecation0.67436370
162MP0003634_abnormal_glial_cell0.66173123
163MP0003045_fibrosis0.64321878
164MP0002932_abnormal_joint_morphology0.64177520
165MP0004808_abnormal_hematopoietic_stem0.63989219
166MP0000470_abnormal_stomach_morphology0.61511081
167MP0003948_abnormal_gas_homeostasis0.61510758
168MP0002933_joint_inflammation0.61000931
169MP0002108_abnormal_muscle_morphology0.60479332
170MP0009384_cardiac_valve_regurgitation0.60000533

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.71247956
2Hyperglycinemia (HP:0002154)4.69003414
3Hyperglycinuria (HP:0003108)4.44324866
4Ependymoma (HP:0002888)3.80917198
5Abnormality of the lower motor neuron (HP:0002366)3.79584577
6Hypochromic microcytic anemia (HP:0004840)3.77683988
7Abnormality of glycine metabolism (HP:0010895)3.74613673
8Abnormality of serine family amino acid metabolism (HP:0010894)3.74613673
9Deep venous thrombosis (HP:0002625)3.70170522
10Gout (HP:0001997)3.56616919
11Abnormality of monocarboxylic acid metabolism (HP:0010996)3.49629043
12Intrahepatic cholestasis (HP:0001406)3.47553358
13Cerebral aneurysm (HP:0004944)3.26856193
14Broad face (HP:0000283)3.24277374
15Eczematoid dermatitis (HP:0000976)3.22368615
16Atrioventricular block (HP:0001678)2.98093809
17Xanthomatosis (HP:0000991)2.97234800
18Hyperammonemia (HP:0001987)2.94800169
19Astrocytoma (HP:0009592)2.89056533
20Abnormality of the astrocytes (HP:0100707)2.89056533
21Hypoalphalipoproteinemia (HP:0003233)2.88752003
22Abnormality of aromatic amino acid family metabolism (HP:0004338)2.80237949
23Hyperlipoproteinemia (HP:0010980)2.76748045
24Abnormality of the fingertips (HP:0001211)2.73867896
25Increased IgE level (HP:0003212)2.64440849
26Muscle fiber splitting (HP:0003555)2.63684780
27Abnormality of sulfur amino acid metabolism (HP:0004339)2.63090178
28Difficulty climbing stairs (HP:0003551)2.60993364
29Abnormality of the labia minora (HP:0012880)2.58494247
30Hyperglycemia (HP:0003074)2.57806072
31Bundle branch block (HP:0011710)2.57168507
32Hyperacusis (HP:0010780)2.54514056
33Hypolipoproteinemia (HP:0010981)2.52199976
34Shallow orbits (HP:0000586)2.49908033
35Hypobetalipoproteinemia (HP:0003563)2.49245088
36Exercise-induced myalgia (HP:0003738)2.47562080
37Ketosis (HP:0001946)2.46274943
38Impulsivity (HP:0100710)2.43955792
39Abnormality of the Achilles tendon (HP:0005109)2.43648457
40Ventricular fibrillation (HP:0001663)2.43585669
41Increased connective tissue (HP:0009025)2.43353318
42Thin bony cortex (HP:0002753)2.42917968
43Metaphyseal cupping (HP:0003021)2.42726681
44Abnormality of serum amino acid levels (HP:0003112)2.42149948
45Cervical subluxation (HP:0003308)2.41798191
46Multiple enchondromatosis (HP:0005701)2.40342149
47Polycythemia (HP:0001901)2.39798140
48Distal lower limb muscle weakness (HP:0009053)2.39173669
49Spastic diplegia (HP:0001264)2.38969957
50Glioma (HP:0009733)2.35532411
51Pseudobulbar signs (HP:0002200)2.34630200
52Increased variability in muscle fiber diameter (HP:0003557)2.31712434
53Protrusio acetabuli (HP:0003179)2.30815119
54Sudden death (HP:0001699)2.30075998
55Disproportionate tall stature (HP:0001519)2.25924596
56Ankle clonus (HP:0011448)2.25084587
57Shawl scrotum (HP:0000049)2.24345549
58Supranuclear gaze palsy (HP:0000605)2.23247562
59Global brain atrophy (HP:0002283)2.23201741
60Long palpebral fissure (HP:0000637)2.22389995
61Dysmetric saccades (HP:0000641)2.21824914
62Difficulty running (HP:0009046)2.21554401
63Reticulocytosis (HP:0001923)2.21207010
64Tetraplegia (HP:0002445)2.20706734
65Complement deficiency (HP:0004431)2.18279388
66J-shaped sella turcica (HP:0002680)2.17317401
67Right ventricular cardiomyopathy (HP:0011663)2.17082082
68Achilles tendon contracture (HP:0001771)2.14742931
69Aneurysm (HP:0002617)2.14479602
70Heart block (HP:0012722)2.13201474
71Hyporeflexia of lower limbs (HP:0002600)2.12630486
72Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.11859742
73Gingivitis (HP:0000230)2.10913220
74Stridor (HP:0010307)2.10894683
75EMG: neuropathic changes (HP:0003445)2.10347262
76Hypoglycemic coma (HP:0001325)2.10137418
77Mitral regurgitation (HP:0001653)2.08819931
78Hypercortisolism (HP:0001578)2.08668540
79Annular pancreas (HP:0001734)2.08279333
80Distal lower limb amyotrophy (HP:0008944)2.07898859
81Ventricular tachycardia (HP:0004756)2.07395673
82Cellulitis (HP:0100658)2.06862631
83Ulnar bowing (HP:0003031)2.04994130
84Peritonitis (HP:0002586)2.04639376
85Hemorrhage of the eye (HP:0011885)2.01729755
86Abnormality of skeletal muscle fiber size (HP:0012084)2.00850891
87Bronchomalacia (HP:0002780)1.99847787
88Myopathic facies (HP:0002058)1.99437082
89Flat acetabular roof (HP:0003180)1.99123455
90Centrally nucleated skeletal muscle fibers (HP:0003687)1.98797376
91Germ cell neoplasia (HP:0100728)1.98689139
92Exercise-induced muscle cramps (HP:0003710)1.98481573
93Easy fatigability (HP:0003388)1.97308443
94Skin nodule (HP:0200036)1.97304584
95Epidermoid cyst (HP:0200040)1.97302305
96Turricephaly (HP:0000262)1.97000638
97Abnormal atrioventricular conduction (HP:0005150)1.96239309
98Myoglobinuria (HP:0002913)1.95958442
99Cholelithiasis (HP:0001081)1.95615155
100Increased purine levels (HP:0004368)1.94526439
101Hyperuricemia (HP:0002149)1.94526439
102Broad metatarsal (HP:0001783)1.93785082
103Abnormality of the salivary glands (HP:0010286)1.91382731
104Neoplasm of the oral cavity (HP:0100649)1.91130854
105Areflexia of lower limbs (HP:0002522)1.89566573
106Lymphangioma (HP:0100764)1.88753213
107Segmental peripheral demyelination/remyelination (HP:0003481)1.87128017
108Biconcave vertebral bodies (HP:0004586)1.87090102
109Abnormality of macrophages (HP:0004311)1.87084947
110Distal upper limb amyotrophy (HP:0007149)1.85513095
111Upper limb amyotrophy (HP:0009129)1.85513095
112Cortical dysplasia (HP:0002539)1.84857149
113Neuronal loss in central nervous system (HP:0002529)1.84586049
114Recurrent gram-negative bacterial infections (HP:0005420)1.84576928
115Angiofibromas (HP:0010615)1.84565540
116Adenoma sebaceum (HP:0009720)1.84565540
117Abnormal cartilage morphology (HP:0002763)1.82949892
118Ventricular arrhythmia (HP:0004308)1.82857259
119Ketoacidosis (HP:0001993)1.82054439
120Abnormality of pyrimidine metabolism (HP:0004353)1.81695447
121Status epilepticus (HP:0002133)1.81539172
122Slow saccadic eye movements (HP:0000514)1.81100439
123Neoplasm of striated muscle (HP:0009728)1.80476063
124Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.75845862
125Polygenic inheritance (HP:0010982)1.75817694
126Irritability (HP:0000737)1.75730968
127Spinal canal stenosis (HP:0003416)1.75092936
128Facial hemangioma (HP:0000329)1.74976863
129Rhabdomyolysis (HP:0003201)1.74541232
130Neurofibrillary tangles (HP:0002185)1.74313203
131Dislocated radial head (HP:0003083)1.74094169
132Recurrent abscess formation (HP:0002722)1.73703678
133Abnormality of the radial head (HP:0003995)1.73451800
134Hypochromic anemia (HP:0001931)1.73372143
135Rib fusion (HP:0000902)1.72134654
136Abnormality of nucleobase metabolism (HP:0010932)1.71365124
137Myositis (HP:0100614)1.70939974
138Mildly elevated creatine phosphokinase (HP:0008180)1.70782261
139Genu recurvatum (HP:0002816)1.70536673
140Poikilocytosis (HP:0004447)1.68737111
141Precocious puberty (HP:0000826)1.68713525
142Abnormality of the distal phalanx of the thumb (HP:0009617)1.68467503
143Abnormality of lateral ventricle (HP:0030047)1.67188476
144Cerebral inclusion bodies (HP:0100314)1.67051694
145Onion bulb formation (HP:0003383)1.67031632
146Abnormal gallbladder morphology (HP:0012437)1.66820353
147Abnormality of fatty-acid metabolism (HP:0004359)1.66635397
148Neoplasm of the heart (HP:0100544)1.66480513
149Abnormality of purine metabolism (HP:0004352)1.66199963
150Blue sclerae (HP:0000592)1.66199397
151Thin ribs (HP:0000883)1.65410776
152Asymmetry of the thorax (HP:0001555)1.65403513
153Hand muscle atrophy (HP:0009130)1.64293381
154Abnormality of glutamine family amino acid metabolism (HP:0010902)1.64019289
155Lower limb amyotrophy (HP:0007210)1.63404337
156Abnormality of the thoracic spine (HP:0100711)1.62786406
157Visceral angiomatosis (HP:0100761)1.62636794
158Pointed chin (HP:0000307)1.62583087
159Esophageal varix (HP:0002040)1.62467973
160Abnormality of methionine metabolism (HP:0010901)1.61974408
161Medulloblastoma (HP:0002885)1.61865359
162Fragile skin (HP:0001030)1.61608202
163Abnormality of the aortic arch (HP:0012303)1.61464649
164Abnormal vertebral ossification (HP:0100569)1.61436273
165Deformed sella turcica (HP:0002681)1.61263751
166Atelectasis (HP:0100750)1.61043571
167Asymmetric septal hypertrophy (HP:0001670)1.60812775
168Prolonged partial thromboplastin time (HP:0003645)1.60725402
169Gastrointestinal infarctions (HP:0005244)1.59953946
170Pelvic girdle muscle weakness (HP:0003749)1.59485128
171Dilatation of the ascending aorta (HP:0005111)1.59336278
172Neonatal onset (HP:0003623)1.59208998
173Sleep apnea (HP:0010535)1.59106381
174Recurrent bacterial skin infections (HP:0005406)1.58941531
175Macroorchidism (HP:0000053)1.58733965
176Enlarged penis (HP:0000040)1.58173964
177Abnormality of aspartate family amino acid metabolism (HP:0010899)1.57926109
178Back pain (HP:0003418)1.57719632
179Decreased motor nerve conduction velocity (HP:0003431)1.55689621
180Diplopia (HP:0000651)1.54828681
181Abnormality of binocular vision (HP:0011514)1.54828681
182Hyperparathyroidism (HP:0000843)1.54827664
183Mitral valve prolapse (HP:0001634)1.54348855
184Urinary glycosaminoglycan excretion (HP:0003541)1.54056370
185Mucopolysacchariduria (HP:0008155)1.54056370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.91839919
2PRPF4B3.40011939
3TRIB33.16369266
4NEK13.12162409
5LATS22.95544926
6SMG12.69630851
7BCKDK2.37124435
8EPHA22.27517246
9AKT32.16151280
10ICK2.15218598
11PKN22.08971401
12LATS12.02239803
13PNCK2.02006907
14RIPK41.97122997
15MAP3K91.95565810
16NEK21.87075857
17WEE11.79775183
18MARK21.79033430
19TNK21.69139295
20TTK1.68109946
21STK381.64833993
22EPHB11.64768847
23ALK1.63990547
24ERN11.60196005
25EEF2K1.57152843
26TYRO31.54507785
27PRKD21.52434408
28TTN1.51096283
29FGFR41.45872863
30BUB11.41989361
31PDK41.41679397
32PDK31.41679397
33TSSK61.37614539
34TAOK11.37379030
35* MTOR1.36826795
36BRD41.33501386
37PHKG11.32554067
38PHKG21.32554067
39SIK11.30723514
40RPS6KA21.26590259
41RIPK11.24831735
42MAP3K11.22205572
43MAP2K41.21798763
44SIK31.18479954
45GRK61.16735939
46MAP4K11.16646532
47MAP3K61.16160913
48MAP3K101.15565176
49STK38L1.15218838
50CDK41.13729465
51DYRK31.12523996
52PAK61.09593951
53PDGFRA1.06457454
54MAP3K131.05432739
55CAMKK11.04000566
56ZAP701.02702213
57RPS6KL11.02488603
58RPS6KC11.02488603
59IRAK41.02133480
60PINK10.99895795
61PDPK10.97866030
62HIPK20.95335876
63CDK60.94929930
64MARK10.94819258
65MAP3K70.93760469
66PLK10.91088891
67RPS6KB20.90175070
68BMX0.88638201
69* PRKAA10.86040449
70TYK20.84520617
71MAP3K40.81890702
72MAP2K20.81660742
73RPS6KA60.81543051
74RET0.80903339
75CSK0.79829881
76MAPK110.79169414
77IRAK20.78744509
78KSR20.77404204
79PTK60.76499310
80CSNK1E0.76472100
81BLK0.76408155
82CHEK20.74890025
83CDK20.73162416
84STK30.72980996
85IRAK30.72485448
86FES0.71923764
87CDK70.71874288
88TBK10.70348019
89STK110.69420184
90PDK10.69145257
91PRKCI0.69133329
92MAPKAPK30.68818362
93MAP2K30.66455460
94CHEK10.65975472
95CAMK1D0.65856684
96DDR20.65348948
97MAPK70.63839980
98PDK20.63498085
99PRKCH0.62468188
100SGK30.62341834
101UHMK10.61531387
102PAK40.61448352
103AKT20.61345571
104PTK20.61021127
105CAMK40.58246497
106CAMK10.56288268
107HCK0.55582615
108DYRK1B0.55453331
109RPS6KA10.54828560
110MAP3K110.54739101
111CDC42BPA0.53518034
112CAMK1G0.52754262
113MAP3K30.51648165
114LRRK20.51223214
115GSK3A0.50136777
116CSNK1D0.49578176
117FGFR30.49240494
118ARAF0.48531256
119PRKD10.47126047
120NTRK30.47116537
121SIK20.46343182
122MAP3K20.45925751
123SGK4940.45528067
124SGK2230.45528067
125FGR0.45506766
126FGFR10.45346466
127PIM10.45329662
128ERBB20.44728938
129AURKA0.44654533
130CHUK0.44520539
131JAK20.44518400
132MAPK120.44478306
133CDK10.43910552
134LMTK20.43531077
135MAP3K80.43469904
136PLK30.42958518
137MAPK100.42708018
138KSR10.42514698
139DYRK20.42380653
140PRKD30.42170635
141AURKB0.41908874
142PRKAA20.41741582
143PRKG20.41737566
144PRKCZ0.41024536
145NTRK10.40905338
146GSK3B0.40781913
147BTK0.40635775
148DAPK20.40607465
149RPS6KA30.40222141
150PDGFRB0.39756199
151MAP3K50.39254798
152DMPK0.38947093
153MAPK80.38372638
154TAOK20.38235754

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.96133807
2Nitrogen metabolism_Homo sapiens_hsa009103.60957171
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.23616477
4Vitamin B6 metabolism_Homo sapiens_hsa007503.23032578
5Arginine biosynthesis_Homo sapiens_hsa002203.00661559
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.98406167
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.72355765
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.54920106
9Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.19288199
10Acute myeloid leukemia_Homo sapiens_hsa052212.10013586
11Biosynthesis of amino acids_Homo sapiens_hsa012302.06962426
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.00961830
13Fatty acid degradation_Homo sapiens_hsa000711.99466203
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.92886366
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91148817
16VEGF signaling pathway_Homo sapiens_hsa043701.87365094
17Tryptophan metabolism_Homo sapiens_hsa003801.82015773
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.81030048
19Carbon metabolism_Homo sapiens_hsa012001.77285193
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.75234079
21Chronic myeloid leukemia_Homo sapiens_hsa052201.74838529
22Non-small cell lung cancer_Homo sapiens_hsa052231.73491856
23Butanoate metabolism_Homo sapiens_hsa006501.68258488
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.60669767
25Lysine degradation_Homo sapiens_hsa003101.59225622
26Fatty acid metabolism_Homo sapiens_hsa012121.53792529
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.52402326
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.51460124
29Osteoclast differentiation_Homo sapiens_hsa043801.51119543
30Other glycan degradation_Homo sapiens_hsa005111.49137584
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48359219
32B cell receptor signaling pathway_Homo sapiens_hsa046621.47203384
33PPAR signaling pathway_Homo sapiens_hsa033201.45582435
34Propanoate metabolism_Homo sapiens_hsa006401.44227115
35Renal cell carcinoma_Homo sapiens_hsa052111.43920075
36Complement and coagulation cascades_Homo sapiens_hsa046101.42047657
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.40083630
38Phospholipase D signaling pathway_Homo sapiens_hsa040721.40071231
39GnRH signaling pathway_Homo sapiens_hsa049121.40005499
40ErbB signaling pathway_Homo sapiens_hsa040121.36949346
41Choline metabolism in cancer_Homo sapiens_hsa052311.35681091
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.35009904
43Long-term potentiation_Homo sapiens_hsa047201.32949639
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30938607
45Glioma_Homo sapiens_hsa052141.30391081
46Bile secretion_Homo sapiens_hsa049761.30171936
47Selenocompound metabolism_Homo sapiens_hsa004501.28904336
48Fructose and mannose metabolism_Homo sapiens_hsa000511.28732786
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28406399
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.25584322
51Pentose phosphate pathway_Homo sapiens_hsa000301.23252333
52Folate biosynthesis_Homo sapiens_hsa007901.22483557
53Pancreatic cancer_Homo sapiens_hsa052121.21519393
54Pentose and glucuronate interconversions_Homo sapiens_hsa000401.20824697
55beta-Alanine metabolism_Homo sapiens_hsa004101.18222992
56Estrogen signaling pathway_Homo sapiens_hsa049151.17757634
57Sulfur relay system_Homo sapiens_hsa041221.17480689
58RNA transport_Homo sapiens_hsa030131.16686684
59Inositol phosphate metabolism_Homo sapiens_hsa005621.11419483
60Glycosaminoglycan degradation_Homo sapiens_hsa005311.09945475
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08176917
62* mTOR signaling pathway_Homo sapiens_hsa041501.06854575
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06713070
64Prolactin signaling pathway_Homo sapiens_hsa049171.05979990
65Amoebiasis_Homo sapiens_hsa051461.03083388
66Thyroid cancer_Homo sapiens_hsa052161.03001092
67Leukocyte transendothelial migration_Homo sapiens_hsa046701.02924695
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99761322
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95518152
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94816511
71Hepatitis C_Homo sapiens_hsa051600.94290121
72Insulin resistance_Homo sapiens_hsa049310.94204297
73Synaptic vesicle cycle_Homo sapiens_hsa047210.94141156
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94012011
75One carbon pool by folate_Homo sapiens_hsa006700.93306666
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92985912
77Endocytosis_Homo sapiens_hsa041440.92642825
78Arginine and proline metabolism_Homo sapiens_hsa003300.92284932
79T cell receptor signaling pathway_Homo sapiens_hsa046600.91217100
80Pyruvate metabolism_Homo sapiens_hsa006200.89952643
81MAPK signaling pathway_Homo sapiens_hsa040100.89938976
82Prostate cancer_Homo sapiens_hsa052150.89338698
83Colorectal cancer_Homo sapiens_hsa052100.87708984
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87528023
85Chemokine signaling pathway_Homo sapiens_hsa040620.87045572
86* AMPK signaling pathway_Homo sapiens_hsa041520.86182922
87Insulin signaling pathway_Homo sapiens_hsa049100.85416553
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84519541
89Focal adhesion_Homo sapiens_hsa045100.84416558
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84345574
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84003291
92Phenylalanine metabolism_Homo sapiens_hsa003600.83795467
93Starch and sucrose metabolism_Homo sapiens_hsa005000.83364552
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83107155
95Fat digestion and absorption_Homo sapiens_hsa049750.82916446
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82855540
97Circadian rhythm_Homo sapiens_hsa047100.82061152
98Hepatitis B_Homo sapiens_hsa051610.81988648
99HIF-1 signaling pathway_Homo sapiens_hsa040660.81889772
100* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81120046
101Melanogenesis_Homo sapiens_hsa049160.80870983
102Leishmaniasis_Homo sapiens_hsa051400.80300895
103Rap1 signaling pathway_Homo sapiens_hsa040150.79524765
104Peroxisome_Homo sapiens_hsa041460.79480108
105Tuberculosis_Homo sapiens_hsa051520.79340260
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79182661
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78117823
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78049291
109Fatty acid biosynthesis_Homo sapiens_hsa000610.77002263
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76963773
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.75888454
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75629879
113Proteoglycans in cancer_Homo sapiens_hsa052050.75332236
114TNF signaling pathway_Homo sapiens_hsa046680.74619570
115Cholinergic synapse_Homo sapiens_hsa047250.74587080
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.74402448
117Glucagon signaling pathway_Homo sapiens_hsa049220.73203883
118Oxytocin signaling pathway_Homo sapiens_hsa049210.73033500
119Axon guidance_Homo sapiens_hsa043600.72756235
120Galactose metabolism_Homo sapiens_hsa000520.72424214
121Platelet activation_Homo sapiens_hsa046110.71797682
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71603398
123Chemical carcinogenesis_Homo sapiens_hsa052040.70140687
124Gastric acid secretion_Homo sapiens_hsa049710.69705806
125ABC transporters_Homo sapiens_hsa020100.69313483
126Glycerolipid metabolism_Homo sapiens_hsa005610.68367870
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67961988
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67267229
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.67101400
130Retinol metabolism_Homo sapiens_hsa008300.66261108
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65364062
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.64767742
133Toxoplasmosis_Homo sapiens_hsa051450.62445681
134mRNA surveillance pathway_Homo sapiens_hsa030150.61896565
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61879912
136Malaria_Homo sapiens_hsa051440.61766024
137MicroRNAs in cancer_Homo sapiens_hsa052060.61568201
138Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60920038
139Dorso-ventral axis formation_Homo sapiens_hsa043200.59746684
140Small cell lung cancer_Homo sapiens_hsa052220.59396279
141cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58591898
142cAMP signaling pathway_Homo sapiens_hsa040240.58300664
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58010380
144Influenza A_Homo sapiens_hsa051640.57796758
145Gap junction_Homo sapiens_hsa045400.55444592
146Apoptosis_Homo sapiens_hsa042100.55247404
147Hippo signaling pathway_Homo sapiens_hsa043900.52990977
148Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52051742
149Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50461872
150Tyrosine metabolism_Homo sapiens_hsa003500.49492014
151Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47342997
152Prion diseases_Homo sapiens_hsa050200.46558533
153Cell cycle_Homo sapiens_hsa041100.46432522
154Oocyte meiosis_Homo sapiens_hsa041140.46198888
155Steroid hormone biosynthesis_Homo sapiens_hsa001400.46133013
156Maturity onset diabetes of the young_Homo sapiens_hsa049500.45078518
157Staphylococcus aureus infection_Homo sapiens_hsa051500.44459347
158Caffeine metabolism_Homo sapiens_hsa002320.43379543
159Vitamin digestion and absorption_Homo sapiens_hsa049770.43049811
160FoxO signaling pathway_Homo sapiens_hsa040680.41121771
161Notch signaling pathway_Homo sapiens_hsa043300.40794453
162Dilated cardiomyopathy_Homo sapiens_hsa054140.40107850
163Adherens junction_Homo sapiens_hsa045200.38861975
164Type II diabetes mellitus_Homo sapiens_hsa049300.38460422
165Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38063538
166Bladder cancer_Homo sapiens_hsa052190.36423487
167Hedgehog signaling pathway_Homo sapiens_hsa043400.35813339
168Endometrial cancer_Homo sapiens_hsa052130.33243076
169* Regulation of autophagy_Homo sapiens_hsa041400.32397595
170p53 signaling pathway_Homo sapiens_hsa041150.32202862
171Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31417757
172Basal cell carcinoma_Homo sapiens_hsa052170.28872054
173Histidine metabolism_Homo sapiens_hsa003400.28670210
174Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.27311403
175Tight junction_Homo sapiens_hsa045300.27098280

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