UIMC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein that interacts with Brca1 (breast cancer 1) in a complex to recognize and repair DNA lesions. This protein binds ubiquitinated lysine 63 of histone H2A and H2AX. This protein may also function as a repressor of transcription. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.90272025
2synapsis (GO:0007129)5.19636015
3ribosomal small subunit assembly (GO:0000028)5.05709509
4regulation of meiosis I (GO:0060631)5.01042502
5DNA methylation involved in gamete generation (GO:0043046)4.83243738
6male meiosis I (GO:0007141)4.81186381
7viral transcription (GO:0019083)4.78558560
8translational termination (GO:0006415)4.60943162
9ribosomal small subunit biogenesis (GO:0042274)4.52974787
10male meiosis (GO:0007140)4.25100240
11maturation of SSU-rRNA (GO:0030490)4.23318459
12meiosis I (GO:0007127)4.16951516
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.15630870
14cotranslational protein targeting to membrane (GO:0006613)4.04927098
15translational elongation (GO:0006414)4.04683586
16protein targeting to ER (GO:0045047)4.03565361
17chromosome organization involved in meiosis (GO:0070192)3.97440979
18regulation of histone H3-K9 methylation (GO:0051570)3.85300607
19establishment of protein localization to endoplasmic reticulum (GO:0072599)3.80467489
20protein localization to endoplasmic reticulum (GO:0070972)3.78738026
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.76591880
22meiotic nuclear division (GO:0007126)3.75534083
23interkinetic nuclear migration (GO:0022027)3.72815342
24reciprocal DNA recombination (GO:0035825)3.72783661
25reciprocal meiotic recombination (GO:0007131)3.72783661
26DNA strand elongation involved in DNA replication (GO:0006271)3.68850148
27viral life cycle (GO:0019058)3.65392312
28translational initiation (GO:0006413)3.65170185
29telomere maintenance via semi-conservative replication (GO:0032201)3.64362102
30ribosomal large subunit biogenesis (GO:0042273)3.61414916
31activated T cell proliferation (GO:0050798)3.55327464
32DNA strand elongation (GO:0022616)3.54850865
33cellular protein complex disassembly (GO:0043624)3.53555293
34regulation of memory T cell differentiation (GO:0043380)3.49776952
35regulation of regulatory T cell differentiation (GO:0045589)3.47152756
36neutrophil activation involved in immune response (GO:0002283)3.44654725
37telomere maintenance via recombination (GO:0000722)3.38509857
38positive regulation of granulocyte differentiation (GO:0030854)3.35318127
39protein K11-linked deubiquitination (GO:0035871)3.31800332
40positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.30471932
41centriole replication (GO:0007099)3.30096171
42ribonucleoprotein complex biogenesis (GO:0022613)3.28248324
43DNA unwinding involved in DNA replication (GO:0006268)3.27644238
44formation of translation preinitiation complex (GO:0001731)3.25487015
45positive regulation of mitotic sister chromatid separation (GO:1901970)3.24527265
46positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.24527265
47positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.24527265
48growth hormone receptor signaling pathway (GO:0060396)3.24143355
49mitotic recombination (GO:0006312)3.18793191
50DNA replication initiation (GO:0006270)3.17082200
51hepatocyte apoptotic process (GO:0097284)3.16018502
52protein complex disassembly (GO:0043241)3.14741407
53histone H3-K36 demethylation (GO:0070544)3.13773079
54DNA deamination (GO:0045006)3.12211214
55rRNA catabolic process (GO:0016075)3.10360307
56sister chromatid cohesion (GO:0007062)3.09279334
57embryonic hemopoiesis (GO:0035162)3.08492806
58CENP-A containing nucleosome assembly (GO:0034080)3.08370754
59regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.07271650
60synaptonemal complex assembly (GO:0007130)3.06875369
61meiotic cell cycle process (GO:1903046)3.02630344
62synaptonemal complex organization (GO:0070193)3.02595318
63nuclear-transcribed mRNA catabolic process (GO:0000956)3.02488857
64positive regulation of DNA recombination (GO:0045911)3.02126160
65positive regulation of interleukin-17 production (GO:0032740)3.02117487
66gene silencing by RNA (GO:0031047)3.01669215
67peptidyl-lysine trimethylation (GO:0018023)3.00480648
68telomere maintenance via telomere lengthening (GO:0010833)2.99561600
69macromolecular complex disassembly (GO:0032984)2.99013325
70RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.98751951
71rRNA modification (GO:0000154)2.97074218
72rRNA processing (GO:0006364)2.96029861
73chromatin remodeling at centromere (GO:0031055)2.95072491
74NIK/NF-kappaB signaling (GO:0038061)2.93530862
75maturation of 5.8S rRNA (GO:0000460)2.93503757
76cellular response to growth hormone stimulus (GO:0071378)2.89973097
77positive regulation of gamma-delta T cell activation (GO:0046645)2.89474063
78mRNA catabolic process (GO:0006402)2.88806174
79positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.87179806
80kinetochore organization (GO:0051383)2.86851055
81rRNA metabolic process (GO:0016072)2.85644954
82translation (GO:0006412)2.84343194
83regulation of B cell apoptotic process (GO:0002902)2.83221280
84protein localization to kinetochore (GO:0034501)2.81817696
85DNA methylation (GO:0006306)2.81427840
86DNA alkylation (GO:0006305)2.81427840
87DNA replication checkpoint (GO:0000076)2.80496939
88antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.78932473
89antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.78932473
90RNA catabolic process (GO:0006401)2.78797749
91DNA synthesis involved in DNA repair (GO:0000731)2.76891917
92neutrophil activation (GO:0042119)2.76465593
93regulation of response to tumor cell (GO:0002834)2.75631315
94positive regulation of response to tumor cell (GO:0002836)2.75631315
95positive regulation of immune response to tumor cell (GO:0002839)2.75631315
96regulation of immune response to tumor cell (GO:0002837)2.75631315
97DNA replication-independent nucleosome assembly (GO:0006336)2.74506289
98DNA replication-independent nucleosome organization (GO:0034724)2.74506289
99positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.71821891
100antigen processing and presentation of endogenous antigen (GO:0019883)2.71320880
101neural tube formation (GO:0001841)2.71171615
102ribosome biogenesis (GO:0042254)2.69968396
103leukocyte migration involved in inflammatory response (GO:0002523)2.68864415
104negative regulation of DNA-dependent DNA replication (GO:2000104)2.66568283
105termination of RNA polymerase III transcription (GO:0006386)2.66133296
106transcription elongation from RNA polymerase III promoter (GO:0006385)2.66133296
107positive regulation of isotype switching (GO:0045830)2.65588234
108regulation of DNA endoreduplication (GO:0032875)2.64788889
109proteasome assembly (GO:0043248)2.64618216
110kinetochore assembly (GO:0051382)2.64342938
111rRNA methylation (GO:0031167)2.62577005
112mismatch repair (GO:0006298)2.62281972
113DNA methylation or demethylation (GO:0044728)2.62068815
114telomere maintenance (GO:0000723)2.60770265
115negative regulation of T-helper cell differentiation (GO:0045623)2.60165556
116negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.60165556
117telomere organization (GO:0032200)2.58707191
118regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.58101929
119regulation of B cell receptor signaling pathway (GO:0050855)2.57857084
120antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.57395590
121nucleobase biosynthetic process (GO:0046112)2.57133920
122tRNA methylation (GO:0030488)2.55700720
123somatic diversification of immune receptors via somatic mutation (GO:0002566)2.55131792
124somatic hypermutation of immunoglobulin genes (GO:0016446)2.55131792
125deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.54519676
126positive regulation of cellular response to oxidative stress (GO:1900409)2.54509207
127positive regulation of response to oxidative stress (GO:1902884)2.54509207
128neutrophil mediated immunity (GO:0002446)2.52949180
129cellular response to dsRNA (GO:0071359)2.52753835
130negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.52371638
131positive regulation of mast cell activation (GO:0033005)2.51771977
132meiotic cell cycle (GO:0051321)2.51765680
133mitotic nuclear envelope disassembly (GO:0007077)2.51502523
134positive regulation of protein homooligomerization (GO:0032464)2.51298041
135N-terminal protein amino acid acetylation (GO:0006474)2.51182361
136antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.50700047
137negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.50503646
138histone H2A acetylation (GO:0043968)2.50349897
139nucleotide-excision repair, DNA gap filling (GO:0006297)2.50111168
140snRNA processing (GO:0016180)2.49885421
141protein targeting to membrane (GO:0006612)2.49686850
142centriole assembly (GO:0098534)2.48675194
143negative regulation of B cell apoptotic process (GO:0002903)2.48652348
144spliceosomal complex assembly (GO:0000245)2.48245469
145modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.47574695
146positive regulation by organism of defense response of other organism involved in symbiotic interact2.47574695
147modulation by symbiont of host immune response (GO:0052553)2.47574695
148positive regulation by symbiont of host defense response (GO:0052509)2.47574695
149modulation by symbiont of host defense response (GO:0052031)2.47574695
150modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.47574695
151natural killer cell activation involved in immune response (GO:0002323)2.46610078
152regulation of interferon-beta biosynthetic process (GO:0045357)2.46597209
153pseudouridine synthesis (GO:0001522)2.46094017
154IMP biosynthetic process (GO:0006188)2.45830366
155cellular component biogenesis (GO:0044085)2.44882605
156regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.43698154
157spliceosomal snRNP assembly (GO:0000387)2.43168500
158microglial cell activation (GO:0001774)2.43111669
159establishment of integrated proviral latency (GO:0075713)2.42815837
160transcription-coupled nucleotide-excision repair (GO:0006283)2.42379357
161meiotic chromosome segregation (GO:0045132)2.41990454
162regulation of isotype switching to IgG isotypes (GO:0048302)2.41822790
163regulation of nuclear cell cycle DNA replication (GO:0033262)2.41459554
164protein localization to chromosome, centromeric region (GO:0071459)2.41213107
165double-strand break repair via homologous recombination (GO:0000724)2.40315039
166RNA splicing, via transesterification reactions (GO:0000375)2.39717565
167histone mRNA catabolic process (GO:0071044)2.39379795
168axoneme assembly (GO:0035082)2.39209458
169regulation of mast cell activation (GO:0033003)2.38954146
170histone H3-K4 trimethylation (GO:0080182)2.38930775
171folic acid-containing compound biosynthetic process (GO:0009396)2.38274862
172mRNA splicing, via spliceosome (GO:0000398)2.38062184
173RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.38062184
174DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.37958752
175signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.37852222
176signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.37852222
177signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.37852222
178recombinational repair (GO:0000725)2.37518233
179positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.37481136
180leukocyte degranulation (GO:0043299)2.37047947
181signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.36958040
182intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.36958040
183regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.36532736
184attachment of spindle microtubules to kinetochore (GO:0008608)2.36267027
185purine nucleobase biosynthetic process (GO:0009113)2.36181433
186establishment of protein localization to Golgi (GO:0072600)2.36031069
187exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.35572621
188replication fork processing (GO:0031297)2.35236329
189interferon-gamma production (GO:0032609)2.34897057
190histone H3-K9 demethylation (GO:0033169)2.34140553
191histone H2A ubiquitination (GO:0033522)2.33195012
192positive regulation of histone methylation (GO:0031062)2.30400309
193negative regulation of telomere maintenance (GO:0032205)2.30194804
194peptidyl-lysine methylation (GO:0018022)2.29062492
195antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.28504722
196GMP metabolic process (GO:0046037)2.27446073
197protein K6-linked ubiquitination (GO:0085020)2.27007421

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.94337897
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.58311168
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.17237907
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.03088992
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.98492387
6ZNF274_21170338_ChIP-Seq_K562_Hela2.95609360
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.93864877
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.90982928
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.85946599
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.84212293
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.82001491
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.80651993
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49069167
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.47957215
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.39985333
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.39079898
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.36632072
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34070508
19VDR_23849224_ChIP-Seq_CD4+_Human2.30722242
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.28862781
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.27844488
22IRF8_22096565_ChIP-ChIP_GC-B_Human2.26594911
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.24614093
24FOXP3_21729870_ChIP-Seq_TREG_Human2.18474417
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.18057546
26POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16324225
27XRN2_22483619_ChIP-Seq_HELA_Human2.15319558
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.14571834
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11787576
30EWS_26573619_Chip-Seq_HEK293_Human2.08671936
31CREB1_15753290_ChIP-ChIP_HEK293T_Human2.07971469
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.06265937
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04443582
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.01420207
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00570638
36NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00012042
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.97683993
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.95634446
39IGF1R_20145208_ChIP-Seq_DFB_Human1.93489819
40TAF15_26573619_Chip-Seq_HEK293_Human1.93438720
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.93231239
42ELK1_19687146_ChIP-ChIP_HELA_Human1.91912160
43DCP1A_22483619_ChIP-Seq_HELA_Human1.90970634
44MYC_22102868_ChIP-Seq_BL_Human1.90697136
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88555381
46CIITA_25753668_ChIP-Seq_RAJI_Human1.88543837
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76314801
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75899840
49VDR_22108803_ChIP-Seq_LS180_Human1.72224776
50GBX2_23144817_ChIP-Seq_PC3_Human1.72136843
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71737106
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70305525
53* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67628176
54SPI1_23547873_ChIP-Seq_NB4_Human1.67618670
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66756620
56ER_23166858_ChIP-Seq_MCF-7_Human1.64292219
57TTF2_22483619_ChIP-Seq_HELA_Human1.63759693
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63189285
59FUS_26573619_Chip-Seq_HEK293_Human1.62870075
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.62335626
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.62306340
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.57934489
63* GABP_19822575_ChIP-Seq_HepG2_Human1.57600129
64MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.54640277
65* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54328705
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52270374
67STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.49787671
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48767154
69GATA3_26560356_Chip-Seq_TH2_Human1.47977367
70IRF8_21731497_ChIP-ChIP_J774_Mouse1.46030060
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45273590
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.44316507
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44073075
74VDR_21846776_ChIP-Seq_THP-1_Human1.43906568
75RUNX_20019798_ChIP-Seq_JUKART_Human1.42563216
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41627354
77* TP53_22573176_ChIP-Seq_HFKS_Human1.38850490
78GATA3_27048872_Chip-Seq_THYMUS_Human1.38575961
79NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36696954
80EGR1_23403033_ChIP-Seq_LIVER_Mouse1.36330090
81MYB_26560356_Chip-Seq_TH2_Human1.35142735
82AR_21909140_ChIP-Seq_LNCAP_Human1.34337114
83MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33763398
84MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32527351
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.32267396
86THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31391598
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.27253405
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26762665
89MYB_26560356_Chip-Seq_TH1_Human1.26644326
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26243921
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25516179
92SCL_19346495_ChIP-Seq_HPC-7_Human1.25422988
93RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24967152
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24451777
95STAT3_23295773_ChIP-Seq_U87_Human1.23752262
96TFEB_21752829_ChIP-Seq_HELA_Human1.23706180
97POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23508417
98KDM5A_27292631_Chip-Seq_BREAST_Human1.22344303
99YY1_21170310_ChIP-Seq_MESCs_Mouse1.22249620
100MAF_26560356_Chip-Seq_TH1_Human1.20404201
101GATA3_26560356_Chip-Seq_TH1_Human1.19520680
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18959879
103CBP_20019798_ChIP-Seq_JUKART_Human1.17354050
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17354050
105HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15840965
106IRF1_19129219_ChIP-ChIP_H3396_Human1.14109556
107SALL4_22934838_ChIP-ChIP_CD34+_Human1.13919106
108PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12725405
109STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.12710152
110SMAD_19615063_ChIP-ChIP_OVARY_Human1.11274055
111SMRT_27268052_Chip-Seq_Bcells_Human1.11266554
112TP63_19390658_ChIP-ChIP_HaCaT_Human1.10390176
113P300_19829295_ChIP-Seq_ESCs_Human1.09855637
114* UTX_26944678_Chip-Seq_JUKART_Human1.08547095
115HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08469480
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08271068
117IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08178638
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07880769
119RUNX1_22412390_ChIP-Seq_EML_Mouse1.07432693
120* TCF4_23295773_ChIP-Seq_U87_Human1.07197720
121TP53_16413492_ChIP-PET_HCT116_Human1.05000160
122CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04688211
123ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03650159
124PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03565944
125BCAT_22108803_ChIP-Seq_LS180_Human1.02969812
126E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02285815
127* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02218760
128DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01824863
129MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00411784
130ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00174871
131MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99523698
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99050266
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99050266
134MYC_18940864_ChIP-ChIP_HL60_Human0.98682212
135CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98657469
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98407996
137CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97424074
138CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97386694
139FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96833484
140FOXA1_25329375_ChIP-Seq_VCAP_Human0.96833484
141GATA1_22025678_ChIP-Seq_K562_Human0.96814801
142GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96644137
143BP1_19119308_ChIP-ChIP_Hs578T_Human0.96631535
144MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96556991
145FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95835718
146HOXB7_26014856_ChIP-Seq_BT474_Human0.95122752
147MAF_26560356_Chip-Seq_TH2_Human0.94878762
148GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94123079
149E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93633813
150* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.93266542
151RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92835793
152NFE2_27457419_Chip-Seq_LIVER_Mouse0.91512730
153TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90133011
154EZH2_27294783_Chip-Seq_NPCs_Mouse0.89250766
155IRF8_27001747_Chip-Seq_BMDM_Mouse0.88905847

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.57696838
2MP0003763_abnormal_thymus_physiology3.13438624
3MP0008057_abnormal_DNA_replication3.10595622
4MP0001835_abnormal_antigen_presentation3.09723152
5MP0002396_abnormal_hematopoietic_system2.89209583
6MP0010094_abnormal_chromosome_stability2.78409258
7MP0003111_abnormal_nucleus_morphology2.62958006
8MP0003077_abnormal_cell_cycle2.61072272
9MP0000569_abnormal_digit_pigmentation2.58292357
10MP0008995_early_reproductive_senescence2.54407085
11MP0002102_abnormal_ear_morphology2.45478678
12MP0008007_abnormal_cellular_replicative2.44482115
13MP0005671_abnormal_response_to2.44280518
14MP0003436_decreased_susceptibility_to2.43688047
15MP0000685_abnormal_immune_system2.43621299
16MP0004957_abnormal_blastocyst_morpholog2.34553718
17MP0001800_abnormal_humoral_immune2.21677792
18MP0003646_muscle_fatigue2.17091303
19MP0008058_abnormal_DNA_repair2.14250869
20MP0009333_abnormal_splenocyte_physiolog2.09894125
21MP0005000_abnormal_immune_tolerance2.04075111
22MP0002398_abnormal_bone_marrow2.03821304
23MP0001853_heart_inflammation2.01988035
24MP0002452_abnormal_antigen_presenting1.96197409
25MP0009785_altered_susceptibility_to1.94295173
26MP0002420_abnormal_adaptive_immunity1.91401896
27MP0001819_abnormal_immune_cell1.88903495
28MP0002723_abnormal_immune_serum1.87405437
29MP0004808_abnormal_hematopoietic_stem1.83640925
30MP0005025_abnormal_response_to1.81178528
31MP0002837_dystrophic_cardiac_calcinosis1.77423366
32MP0002722_abnormal_immune_system1.76018546
33MP0005387_immune_system_phenotype1.76012456
34MP0001790_abnormal_immune_system1.76012456
35MP0000703_abnormal_thymus_morphology1.75907841
36MP0003787_abnormal_imprinting1.75383643
37MP0000689_abnormal_spleen_morphology1.72154261
38MP0000716_abnormal_immune_system1.68572109
39MP0001929_abnormal_gametogenesis1.67011827
40MP0002405_respiratory_system_inflammati1.65301231
41MP0002148_abnormal_hypersensitivity_rea1.64895298
42MP0002210_abnormal_sex_determination1.63901072
43MP0000490_abnormal_crypts_of1.60954216
44MP0002166_altered_tumor_susceptibility1.60171267
45MP0001545_abnormal_hematopoietic_system1.59754974
46MP0005397_hematopoietic_system_phenotyp1.59754974
47MP0002429_abnormal_blood_cell1.58604427
48MP0003786_premature_aging1.55918323
49MP0000427_abnormal_hair_cycle1.52959269
50MP0002419_abnormal_innate_immunity1.50727454
51MP0008877_abnormal_DNA_methylation1.50441863
52MP0005084_abnormal_gallbladder_morpholo1.50072755
53MP0004147_increased_porphyrin_level1.47810782
54MP0008932_abnormal_embryonic_tissue1.47543483
55MP0000015_abnormal_ear_pigmentation1.47279041
56MP0002928_abnormal_bile_duct1.47178217
57MP0010352_gastrointestinal_tract_polyps1.44866091
58MP0000372_irregular_coat_pigmentation1.44317077
59MP0002006_tumorigenesis1.43454848
60MP0003724_increased_susceptibility_to1.40749187
61MP0003300_gastrointestinal_ulcer1.40434006
62MP0000383_abnormal_hair_follicle1.39981321
63MP0002019_abnormal_tumor_incidence1.39485321
64MP0005389_reproductive_system_phenotype1.39294179
65MP0002132_abnormal_respiratory_system1.38334806
66MP0005083_abnormal_biliary_tract1.36861188
67MP0005464_abnormal_platelet_physiology1.36514904
68MP0003890_abnormal_embryonic-extraembry1.26447351
69MP0001873_stomach_inflammation1.26132838
70MP0003698_abnormal_male_reproductive1.25508914
71MP0000653_abnormal_sex_gland1.25505605
72MP0010155_abnormal_intestine_physiology1.24080230
73MP0003718_maternal_effect1.23657301
74MP0000858_altered_metastatic_potential1.23247244
75MP0002160_abnormal_reproductive_system1.23210834
76MP0008260_abnormal_autophagy1.23072285
77MP0001145_abnormal_male_reproductive1.21758181
78MP0002653_abnormal_ependyma_morphology1.21145942
79MP0000350_abnormal_cell_proliferation1.19138005
80MP0005174_abnormal_tail_pigmentation1.18969853
81MP0001845_abnormal_inflammatory_respons1.17803436
82MP0005075_abnormal_melanosome_morpholog1.17561203
83MP0002876_abnormal_thyroid_physiology1.17249115
84MP0003186_abnormal_redox_activity1.12673735
85MP0006035_abnormal_mitochondrial_morpho1.07735628
86MP0002277_abnormal_respiratory_mucosa1.07528054
87MP0000313_abnormal_cell_death1.05755892
88MP0006292_abnormal_olfactory_placode1.04487193
89MP0001919_abnormal_reproductive_system1.04201502
90MP0006054_spinal_hemorrhage1.02563831
91MP0001533_abnormal_skeleton_physiology0.98799156
92MP0009379_abnormal_foot_pigmentation0.96895401
93MP0005646_abnormal_pituitary_gland0.94780756
94MP0001730_embryonic_growth_arrest0.94645600
95MP0003011_delayed_dark_adaptation0.94572974
96MP0005379_endocrine/exocrine_gland_phen0.93747773
97MP0002933_joint_inflammation0.90928709
98MP0005023_abnormal_wound_healing0.89972186
99MP0004381_abnormal_hair_follicle0.89623823
100MP0003866_abnormal_defecation0.87072437
101MP0008469_abnormal_protein_level0.86156475
102MP0001293_anophthalmia0.84708304
103MP0004947_skin_inflammation0.84301503
104MP0002163_abnormal_gland_morphology0.82565218
105MP0003448_altered_tumor_morphology0.81627816
106MP0008872_abnormal_physiological_respon0.81032101
107MP0009278_abnormal_bone_marrow0.79642408
108MP0003252_abnormal_bile_duct0.79542120
109MP0000647_abnormal_sebaceous_gland0.79134031
110MP0010678_abnormal_skin_adnexa0.79047027
111MP0003303_peritoneal_inflammation0.77995010
112MP0010307_abnormal_tumor_latency0.77518981
113MP0009763_increased_sensitivity_to0.75130568
114MP0009764_decreased_sensitivity_to0.73983423
115MP0008004_abnormal_stomach_pH0.73720249
116MP0003566_abnormal_cell_adhesion0.73538135
117MP0001986_abnormal_taste_sensitivity0.72639162
118MP0005310_abnormal_salivary_gland0.70587116
119MP0002095_abnormal_skin_pigmentation0.70445818
120MP0002080_prenatal_lethality0.70048757
121MP0003943_abnormal_hepatobiliary_system0.69638047
122MP0001672_abnormal_embryogenesis/_devel0.69494894
123MP0005380_embryogenesis_phenotype0.69494894
124MP0001697_abnormal_embryo_size0.66831582
125MP0003984_embryonic_growth_retardation0.65576693
126MP0002877_abnormal_melanocyte_morpholog0.65559036
127MP0009765_abnormal_xenobiotic_induced0.64988782
128MP0002088_abnormal_embryonic_growth/wei0.63304077
129MP0002009_preneoplasia0.62869921
130MP0002138_abnormal_hepatobiliary_system0.60878510
131MP0001119_abnormal_female_reproductive0.60380707
132MP0005390_skeleton_phenotype0.60248450
133MP0001243_abnormal_dermal_layer0.58958282
134MP0003656_abnormal_erythrocyte_physiolo0.58686484
135MP0000465_gastrointestinal_hemorrhage0.55847287
136MP0003567_abnormal_fetal_cardiomyocyte0.54046750
137MP0006082_CNS_inflammation0.53783708
138MP0001764_abnormal_homeostasis0.52566488
139MP0000343_altered_response_to0.50911612

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.67017815
2Reticulocytopenia (HP:0001896)4.47193335
3Abnormal number of erythroid precursors (HP:0012131)4.45399400
4Chronic hepatic failure (HP:0100626)4.07119162
5Stomatitis (HP:0010280)3.63467775
6IgM deficiency (HP:0002850)3.54190475
7Agnosia (HP:0010524)3.36564162
8Pancreatic cysts (HP:0001737)3.36181386
9Elevated erythrocyte sedimentation rate (HP:0003565)3.20813838
10Oligodactyly (hands) (HP:0001180)3.19561111
11Pallor (HP:0000980)3.18348826
12Pancreatic fibrosis (HP:0100732)3.12165206
13Birth length less than 3rd percentile (HP:0003561)3.03351369
14Prostate neoplasm (HP:0100787)3.01322126
15T lymphocytopenia (HP:0005403)2.96089267
16Abnormality of T cell number (HP:0011839)2.94825072
17Macrocytic anemia (HP:0001972)2.93091107
1811 pairs of ribs (HP:0000878)2.92320605
19Myositis (HP:0100614)2.88686238
20Aplastic anemia (HP:0001915)2.86088925
21Abnormality of midbrain morphology (HP:0002418)2.83525471
22Molar tooth sign on MRI (HP:0002419)2.83525471
23Nephronophthisis (HP:0000090)2.81771802
24Thrombocytosis (HP:0001894)2.76306884
25Abnormality of T cells (HP:0002843)2.76218190
26True hermaphroditism (HP:0010459)2.71613527
27Lymphoma (HP:0002665)2.68005345
28Papillary thyroid carcinoma (HP:0002895)2.67995720
29Selective tooth agenesis (HP:0001592)2.66860255
30Abnormality of the fingertips (HP:0001211)2.63149454
31Recurrent abscess formation (HP:0002722)2.59520854
32Hypoplastic iliac wings (HP:0002866)2.53859118
33Hypochromic microcytic anemia (HP:0004840)2.53411325
34Abnormality of the renal medulla (HP:0100957)2.53379979
35Recurrent viral infections (HP:0004429)2.52574630
36Abnormality of the heme biosynthetic pathway (HP:0010472)2.50808756
37Chromsome breakage (HP:0040012)2.48883865
38Recurrent fungal infections (HP:0002841)2.47806140
39Rough bone trabeculation (HP:0100670)2.47803367
40IgG deficiency (HP:0004315)2.46194535
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.46085840
42Abnormality of the renal cortex (HP:0011035)2.45989597
43Optic nerve coloboma (HP:0000588)2.45869050
44Abnormality of the prostate (HP:0008775)2.43744100
45Eczematoid dermatitis (HP:0000976)2.42523738
46Recurrent bronchitis (HP:0002837)2.40779870
47Absent/shortened dynein arms (HP:0200106)2.39733600
48Dynein arm defect of respiratory motile cilia (HP:0012255)2.39733600
49Oligodactyly (HP:0012165)2.38419847
50Ectopic kidney (HP:0000086)2.37134597
51Lymphopenia (HP:0001888)2.35866812
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.34647171
53Abnormality of the preputium (HP:0100587)2.29156972
54Abnormality of T cell physiology (HP:0011840)2.28876301
55Myelodysplasia (HP:0002863)2.28729223
56Panhypogammaglobulinemia (HP:0003139)2.28155664
57Mediastinal lymphadenopathy (HP:0100721)2.28128766
58Recurrent bacterial skin infections (HP:0005406)2.26472400
59Amaurosis fugax (HP:0100576)2.23433781
60Increased IgM level (HP:0003496)2.23216974
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.22755556
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20229243
63Abnormality of alanine metabolism (HP:0010916)2.20229243
64Hyperalaninemia (HP:0003348)2.20229243
65Absent thumb (HP:0009777)2.19677113
66Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17220990
67Meningitis (HP:0001287)2.16329321
68Chronic otitis media (HP:0000389)2.16314084
69Abnormality of DNA repair (HP:0003254)2.15963037
70Abnormal ciliary motility (HP:0012262)2.15423630
71Agammaglobulinemia (HP:0004432)2.14002653
72Abnormal trabecular bone morphology (HP:0100671)2.13471412
73Granulocytopenia (HP:0001913)2.13228952
74Poikilocytosis (HP:0004447)2.13151042
75Retrobulbar optic neuritis (HP:0100654)2.13104950
76Optic neuritis (HP:0100653)2.13104950
77Stomach cancer (HP:0012126)2.12379190
78Hypochromic anemia (HP:0001931)2.12164508
79Abnormality of the anterior horn cell (HP:0006802)2.09950312
80Degeneration of anterior horn cells (HP:0002398)2.09950312
81Volvulus (HP:0002580)2.09307745
82Chronic mucocutaneous candidiasis (HP:0002728)2.09243755
83Recurrent cutaneous fungal infections (HP:0011370)2.09243755
84Orchitis (HP:0100796)2.07110169
85Cleft eyelid (HP:0000625)2.04910624
86Type I transferrin isoform profile (HP:0003642)2.04139089
87Pancytopenia (HP:0001876)2.02440773
88Thyroid carcinoma (HP:0002890)2.01409555
89Encephalitis (HP:0002383)2.01195939
90Aplasia/Hypoplasia of the tongue (HP:0010295)2.00836186
91Abnormal biliary tract physiology (HP:0012439)1.99737026
92Bile duct proliferation (HP:0001408)1.99737026
93Congenital, generalized hypertrichosis (HP:0004540)1.99374715
94Trismus (HP:0000211)1.98833090
95Acute myeloid leukemia (HP:0004808)1.98497599
96Oral leukoplakia (HP:0002745)1.96408577
97Colon cancer (HP:0003003)1.96051391
98Abnormal platelet volume (HP:0011876)1.95184053
99Prominent metopic ridge (HP:0005487)1.95176359
100Carpal bone hypoplasia (HP:0001498)1.94305441
101Abnormality of chromosome stability (HP:0003220)1.93949062
102Petechiae (HP:0000967)1.93159431
103Clubbing of toes (HP:0100760)1.90806808
104Anencephaly (HP:0002323)1.90717681
105Cutaneous melanoma (HP:0012056)1.89853897
106Medial flaring of the eyebrow (HP:0010747)1.89346138
107Sloping forehead (HP:0000340)1.89220100
108Cellulitis (HP:0100658)1.89210617
109Ependymoma (HP:0002888)1.89079893
110Vasculitis (HP:0002633)1.88908826
111Bone marrow hypocellularity (HP:0005528)1.88755836
112Progressive inability to walk (HP:0002505)1.87895242
113Epistaxis (HP:0000421)1.87565642
1143-Methylglutaconic aciduria (HP:0003535)1.86885629
115Increased mean platelet volume (HP:0011877)1.86216748
116Premature graying of hair (HP:0002216)1.86213667
117Neutropenia (HP:0001875)1.85725757
118Autoimmune hemolytic anemia (HP:0001890)1.84976789
119Cellular immunodeficiency (HP:0005374)1.84255317
120Attenuation of retinal blood vessels (HP:0007843)1.83663135
121Eosinophilia (HP:0001880)1.82954901
122Cystic liver disease (HP:0006706)1.82632576
123Abnormality of the renal collecting system (HP:0004742)1.82512516
124Duplicated collecting system (HP:0000081)1.81650530
125IgA deficiency (HP:0002720)1.80590124
126Abnormality of eosinophils (HP:0001879)1.80266245
127Postaxial foot polydactyly (HP:0001830)1.79540825
128Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79447056
129Abnormality of B cell number (HP:0010975)1.79225543
130B lymphocytopenia (HP:0010976)1.79225543
131Gastrointestinal stroma tumor (HP:0100723)1.78614210
132Leukopenia (HP:0001882)1.78353133
133Sparse lateral eyebrow (HP:0005338)1.77384405
134Abnormality of the ileum (HP:0001549)1.76114965
135Preaxial hand polydactyly (HP:0001177)1.75257617
136Neoplasm of the pancreas (HP:0002894)1.74640062
137Recurrent pneumonia (HP:0006532)1.74602516
138Acute lymphatic leukemia (HP:0006721)1.74449505
139Patellar aplasia (HP:0006443)1.72250656
140Abnormal number of incisors (HP:0011064)1.72008022
141Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71986616
142Abnormal protein N-linked glycosylation (HP:0012347)1.71986616
143Abnormal protein glycosylation (HP:0012346)1.71986616
144Abnormal glycosylation (HP:0012345)1.71986616
145Muscle fiber atrophy (HP:0100295)1.70966709
146Recurrent skin infections (HP:0001581)1.70906953
147Abnormality of lateral ventricle (HP:0030047)1.70115460
148Leukocytosis (HP:0001974)1.69872932
149Gingival bleeding (HP:0000225)1.68567240
150Meckel diverticulum (HP:0002245)1.68431680
151Emphysema (HP:0002097)1.67942496
152Severe combined immunodeficiency (HP:0004430)1.67637440
153Keratoconjunctivitis sicca (HP:0001097)1.67552860
154Prolonged bleeding time (HP:0003010)1.66832546
155Widely spaced teeth (HP:0000687)1.66420920
156Prominent nose (HP:0000448)1.66385457
157Type 2 muscle fiber atrophy (HP:0003554)1.65530463
158Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.63788789
159Small intestinal stenosis (HP:0012848)1.63693642
160Duodenal stenosis (HP:0100867)1.63693642
161Thyroiditis (HP:0100646)1.63297823
162Microcytic anemia (HP:0001935)1.61584177
163Abnormal respiratory motile cilium morphology (HP:0005938)1.60537169
164Abnormal respiratory epithelium morphology (HP:0012253)1.60537169
165Biliary tract neoplasm (HP:0100574)1.59671786
166Neoplasm of the adrenal cortex (HP:0100641)1.59408463
167Sclerocornea (HP:0000647)1.58768812
168Decreased central vision (HP:0007663)1.57964705
169Congenital hepatic fibrosis (HP:0002612)1.57922960
170Menorrhagia (HP:0000132)1.57248710
171Aplasia/Hypoplasia of the patella (HP:0006498)1.56807450
172Abnormality of the pons (HP:0007361)1.55253145

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.05361111
2PNCK3.22286839
3BUB13.15034740
4MAP4K22.91211395
5NME22.83668724
6MAP4K12.72149779
7NUAK12.63748484
8IRAK42.45448358
9RIPK42.39574137
10PTK2B2.26617387
11WEE12.15433811
12CDC72.08032551
13TXK2.02779815
14RPS6KA41.92406883
15MAP3K141.92048081
16KIT1.91057079
17CAMK1G1.88405701
18CDK191.87424019
19FGR1.84808570
20PIK3CG1.82944069
21BMPR1B1.79098825
22VRK11.78933417
23TYK21.76630008
24PIM21.75027391
25JAK31.67098952
26DYRK31.66421550
27ZAP701.66025537
28FLT31.63698306
29TEC1.61380740
30BMX1.61380421
31IRAK31.60929393
32NLK1.54452536
33STK101.50961673
34STK161.50365025
35MAP3K101.41688363
36ERN11.41480658
37PLK41.40080415
38TLK11.39087502
39BRD41.38772063
40IKBKE1.38559221
41EEF2K1.37929583
42PASK1.34789421
43MAP2K31.33818808
44MAP3K31.33646608
45IKBKB1.33486139
46NEK21.32852573
47BTK1.32523675
48* ATR1.32428303
49KDR1.32116371
50SRPK11.29368469
51CASK1.27746157
52PLK21.26694471
53CDK121.23033240
54CLK11.20694483
55CDK71.20472627
56EIF2AK31.19367439
57OXSR11.17709909
58TBK11.16983237
59STK41.16205640
60EIF2AK11.15314569
61AURKB1.15067559
62RPS6KB21.13953419
63PIM11.12824867
64MKNK11.12785717
65MAP2K61.11856932
66MST41.09507908
67STK31.07707192
68CHUK1.07015172
69TGFBR11.06945998
70ACVR1B1.05643898
71BRSK21.04001800
72MAP3K51.03767157
73SYK1.02879150
74BLK1.01991393
75ITK1.01637401
76PLK11.01631568
77TTK1.00822999
78FGFR40.98012535
79PDK20.97727513
80TSSK60.94783834
81FES0.94175955
82IRAK20.93395433
83LRRK20.92437006
84MUSK0.91245753
85BCR0.89945557
86LCK0.89925931
87CDK40.89488820
88EIF2AK20.87689509
89RPS6KA50.87232696
90ZAK0.85634066
91GRK60.84040975
92CSF1R0.82541754
93ADRBK20.81233609
94LYN0.80297169
95CSK0.79142301
96MKNK20.78268189
97TNK20.77834851
98TESK20.77261212
99SIK30.77163397
100MAP3K80.75768909
101MAPK130.73229328
102PAK30.70900278
103IRAK10.70489365
104KSR10.69909279
105JAK10.67351423
106SIK20.66271169
107GRK10.64794878
108TAOK30.62691152
109TNIK0.62036142
110MET0.61418859
111PRKCQ0.60147682
112TRPM70.59723680
113HIPK20.58519722
114MAPKAPK30.58454588
115* CHEK10.55549081
116MARK30.55038222
117TGFBR20.54959863
118SGK20.54392790
119WNK40.54005816
120MAPKAPK20.53941746
121DYRK1B0.53521688
122CSNK2A10.52542921
123CCNB10.50518051
124CDK60.49345078
125* ATM0.46873024
126CAMK1D0.46796786
127PLK30.46504022
128CSNK2A20.46271461
129STK110.45753838
130YES10.45516314
131BMPR20.45234712
132JAK20.43590756
133RPS6KA60.42918377
134ADRBK10.42915195
135RAF10.42591510
136STK240.42472959
137PRKCI0.42402221
138AURKA0.42103732
139TAOK20.41934181
140MAP3K130.41859464
141MELK0.41441414
142TRIM280.41293777
143BCKDK0.41237335
144PDGFRB0.40007195
145HCK0.39537678
146STK390.38575739
147MATK0.35157583
148WNK30.32805590
149MAP3K40.32092914

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.00352209
2DNA replication_Homo sapiens_hsa030303.93424523
3Mismatch repair_Homo sapiens_hsa034303.46944056
4Proteasome_Homo sapiens_hsa030502.90922007
5RNA polymerase_Homo sapiens_hsa030202.89549891
6Spliceosome_Homo sapiens_hsa030402.78986166
7Homologous recombination_Homo sapiens_hsa034402.65600064
8Base excision repair_Homo sapiens_hsa034102.47789565
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.47638321
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.26741053
11Primary immunodeficiency_Homo sapiens_hsa053402.19077151
12One carbon pool by folate_Homo sapiens_hsa006702.14205024
13Non-homologous end-joining_Homo sapiens_hsa034502.08265215
14Pyrimidine metabolism_Homo sapiens_hsa002402.03216543
15Regulation of autophagy_Homo sapiens_hsa041401.92214089
16Nucleotide excision repair_Homo sapiens_hsa034201.91767998
17RNA transport_Homo sapiens_hsa030131.90223672
18Fanconi anemia pathway_Homo sapiens_hsa034601.84673559
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74383581
20Antigen processing and presentation_Homo sapiens_hsa046121.70891643
21Cell cycle_Homo sapiens_hsa041101.68949898
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.65859946
23Protein export_Homo sapiens_hsa030601.65672494
24Dorso-ventral axis formation_Homo sapiens_hsa043201.63565970
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.62612748
26RNA degradation_Homo sapiens_hsa030181.53720384
27Measles_Homo sapiens_hsa051621.48717018
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.46259571
29Nitrogen metabolism_Homo sapiens_hsa009101.45047469
30Herpes simplex infection_Homo sapiens_hsa051681.43992319
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.42346840
32p53 signaling pathway_Homo sapiens_hsa041151.42276735
33Epstein-Barr virus infection_Homo sapiens_hsa051691.36714162
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34416342
35Basal transcription factors_Homo sapiens_hsa030221.32674348
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31703191
37Phototransduction_Homo sapiens_hsa047441.29546454
38Platelet activation_Homo sapiens_hsa046111.26601446
39Allograft rejection_Homo sapiens_hsa053301.20298838
40Hematopoietic cell lineage_Homo sapiens_hsa046401.17391191
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.10727333
42Legionellosis_Homo sapiens_hsa051341.09067861
43Leishmaniasis_Homo sapiens_hsa051401.07740317
44Graft-versus-host disease_Homo sapiens_hsa053321.06162238
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06059671
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98878400
47Chemokine signaling pathway_Homo sapiens_hsa040620.94954590
48Purine metabolism_Homo sapiens_hsa002300.93827875
49mRNA surveillance pathway_Homo sapiens_hsa030150.93798358
50HTLV-I infection_Homo sapiens_hsa051660.92252964
51Apoptosis_Homo sapiens_hsa042100.90679151
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90192886
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89724954
54FoxO signaling pathway_Homo sapiens_hsa040680.89614072
55Influenza A_Homo sapiens_hsa051640.88152594
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85831969
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85573081
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84984934
59Viral carcinogenesis_Homo sapiens_hsa052030.84844526
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84129916
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.82511249
62Alcoholism_Homo sapiens_hsa050340.80658608
63Systemic lupus erythematosus_Homo sapiens_hsa053220.80573825
64Folate biosynthesis_Homo sapiens_hsa007900.80512701
65Linoleic acid metabolism_Homo sapiens_hsa005910.79596510
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.78981678
67Olfactory transduction_Homo sapiens_hsa047400.77832326
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76927639
69Selenocompound metabolism_Homo sapiens_hsa004500.75387228
70Sulfur relay system_Homo sapiens_hsa041220.75335178
71Osteoclast differentiation_Homo sapiens_hsa043800.74123565
72Hepatitis B_Homo sapiens_hsa051610.73639472
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73573551
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72745419
75T cell receptor signaling pathway_Homo sapiens_hsa046600.72025604
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.70453050
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69878525
78Viral myocarditis_Homo sapiens_hsa054160.69348131
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68032414
80Acute myeloid leukemia_Homo sapiens_hsa052210.67827412
81B cell receptor signaling pathway_Homo sapiens_hsa046620.67679751
82mTOR signaling pathway_Homo sapiens_hsa041500.67082976
83Caffeine metabolism_Homo sapiens_hsa002320.65698083
84Melanoma_Homo sapiens_hsa052180.65373259
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65155142
86ABC transporters_Homo sapiens_hsa020100.64820260
87Autoimmune thyroid disease_Homo sapiens_hsa053200.61777241
88Asthma_Homo sapiens_hsa053100.61355008
89Glutathione metabolism_Homo sapiens_hsa004800.60478130
90Non-small cell lung cancer_Homo sapiens_hsa052230.59942786
91Small cell lung cancer_Homo sapiens_hsa052220.58612674
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.56879418
93Toxoplasmosis_Homo sapiens_hsa051450.55767766
94TNF signaling pathway_Homo sapiens_hsa046680.48462644
95Malaria_Homo sapiens_hsa051440.47452520
96Pentose phosphate pathway_Homo sapiens_hsa000300.46624051
97Pancreatic cancer_Homo sapiens_hsa052120.46232669
98African trypanosomiasis_Homo sapiens_hsa051430.46227498
99MAPK signaling pathway_Homo sapiens_hsa040100.46106917
100Shigellosis_Homo sapiens_hsa051310.43604629
101Type II diabetes mellitus_Homo sapiens_hsa049300.42274639
102TGF-beta signaling pathway_Homo sapiens_hsa043500.41772653
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41550589
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41448086
105Glycerolipid metabolism_Homo sapiens_hsa005610.41207838
106Arachidonic acid metabolism_Homo sapiens_hsa005900.41111156
107Ether lipid metabolism_Homo sapiens_hsa005650.39474169
108Other glycan degradation_Homo sapiens_hsa005110.35663407
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33135848
110N-Glycan biosynthesis_Homo sapiens_hsa005100.32638541
111Tuberculosis_Homo sapiens_hsa051520.31900519
112Type I diabetes mellitus_Homo sapiens_hsa049400.31779810
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31521356
114Pertussis_Homo sapiens_hsa051330.30853378
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.29180683
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29175706
117MicroRNAs in cancer_Homo sapiens_hsa052060.28607268
118Notch signaling pathway_Homo sapiens_hsa043300.28422790
119Hepatitis C_Homo sapiens_hsa051600.26820552
120Huntingtons disease_Homo sapiens_hsa050160.26779431
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.24782998
122Chronic myeloid leukemia_Homo sapiens_hsa052200.24540552
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23315146
124Staphylococcus aureus infection_Homo sapiens_hsa051500.23045348
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21741488
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21299898
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18449406
128Chemical carcinogenesis_Homo sapiens_hsa052040.18443491
129Thyroid cancer_Homo sapiens_hsa052160.17527905
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.17474490
131Prostate cancer_Homo sapiens_hsa052150.17433807
132HIF-1 signaling pathway_Homo sapiens_hsa040660.17170613

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