UHRF1BP1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)5.07202829
2positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.54827134
3nuclear pore complex assembly (GO:0051292)4.50894404
4phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.32850176
5cellular extravasation (GO:0045123)3.96927290
6nuclear pore organization (GO:0006999)3.95880897
7dicarboxylic acid biosynthetic process (GO:0043650)3.82298502
8neutrophil mediated immunity (GO:0002446)3.66280009
9neutrophil activation involved in immune response (GO:0002283)3.55422161
10iron ion import (GO:0097286)3.54866365
11protein targeting to Golgi (GO:0000042)3.48981183
12cysteine metabolic process (GO:0006534)3.48828572
13neural tube formation (GO:0001841)3.48477916
14urea cycle (GO:0000050)3.47134767
15urea metabolic process (GO:0019627)3.47134767
16mitotic sister chromatid cohesion (GO:0007064)3.46947731
17establishment of protein localization to Golgi (GO:0072600)3.42750998
18regulation of clathrin-mediated endocytosis (GO:2000369)3.36792021
19macroautophagy (GO:0016236)3.36461790
20pore complex assembly (GO:0046931)3.35877463
21retrograde transport, vesicle recycling within Golgi (GO:0000301)3.33256394
22response to peptidoglycan (GO:0032494)3.33031255
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.27946844
24L-phenylalanine catabolic process (GO:0006559)3.27946844
25myeloid leukocyte mediated immunity (GO:0002444)3.23782214
26regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.22993028
27early endosome to late endosome transport (GO:0045022)3.22315674
28alpha-linolenic acid metabolic process (GO:0036109)3.18836057
29monoubiquitinated protein deubiquitination (GO:0035520)3.17722197
30negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.15215830
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.14497597
32L-phenylalanine metabolic process (GO:0006558)3.14497597
33positive regulation of cellular amide metabolic process (GO:0034250)3.12599635
34detection of external biotic stimulus (GO:0098581)3.12125213
35mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.10721637
36positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.10721637
37protein carboxylation (GO:0018214)3.10701547
38peptidyl-glutamic acid carboxylation (GO:0017187)3.10701547
39histone mRNA catabolic process (GO:0071044)3.10096179
40regulation of cholesterol homeostasis (GO:2000188)3.06599330
41negative regulation of fibrinolysis (GO:0051918)3.05208700
42macrophage activation involved in immune response (GO:0002281)3.02602338
43positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.01357575
44negative regulation of fibroblast apoptotic process (GO:2000270)3.00145717
45nitrogen cycle metabolic process (GO:0071941)2.95308296
46glutamate metabolic process (GO:0006536)2.93676976
47positive regulation by organism of defense response of other organism involved in symbiotic interact2.93508273
48modulation by symbiont of host immune response (GO:0052553)2.93508273
49positive regulation by symbiont of host defense response (GO:0052509)2.93508273
50modulation by symbiont of host defense response (GO:0052031)2.93508273
51modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.93508273
52modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.93508273
53hepatocyte apoptotic process (GO:0097284)2.93269376
54negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.92983483
55negative regulation of T-helper cell differentiation (GO:0045623)2.92983483
56lysine catabolic process (GO:0006554)2.92585155
57lysine metabolic process (GO:0006553)2.92585155
58sodium ion export (GO:0071436)2.88926724
59positive regulation of gamma-delta T cell activation (GO:0046645)2.87907572
60regulation of B cell receptor signaling pathway (GO:0050855)2.87306891
61aromatic amino acid family catabolic process (GO:0009074)2.85557861
62kynurenine metabolic process (GO:0070189)2.84799543
63locomotory exploration behavior (GO:0035641)2.84790004
64nerve growth factor signaling pathway (GO:0038180)2.84767973
65triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.83721946
66negative regulation of cell killing (GO:0031342)2.80668124
67negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.80668124
68regulation of short-term neuronal synaptic plasticity (GO:0048172)2.80565067
69fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.80056273
70protein targeting to lysosome (GO:0006622)2.79649562
71establishment of protein localization to vacuole (GO:0072666)2.79649562
72protein targeting to vacuole (GO:0006623)2.79649562
73negative regulation of interleukin-12 production (GO:0032695)2.79335054
74microglial cell activation (GO:0001774)2.79208625
75interkinetic nuclear migration (GO:0022027)2.79054432
76macrophage activation (GO:0042116)2.78237521
77drug catabolic process (GO:0042737)2.76614262
78negative regulation of NF-kappaB import into nucleus (GO:0042347)2.76392427
79synaptic vesicle maturation (GO:0016188)2.75119344
80glutamate secretion (GO:0014047)2.75062159
81protein localization to endosome (GO:0036010)2.73242893
82sulfur amino acid catabolic process (GO:0000098)2.72981323
83regulation of fibroblast apoptotic process (GO:2000269)2.72279004
84cytoplasmic mRNA processing body assembly (GO:0033962)2.72129905
85cell wall macromolecule catabolic process (GO:0016998)2.70674371
86killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.70313885
87disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.70313885
88regulation of ARF protein signal transduction (GO:0032012)2.69743912
89regulation of fatty acid beta-oxidation (GO:0031998)2.69472673
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.65641611
91detection of biotic stimulus (GO:0009595)2.63763480
92bile acid biosynthetic process (GO:0006699)2.61192476
93N-terminal protein amino acid acetylation (GO:0006474)2.60517429
94positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.60446427
95positive regulation of macroautophagy (GO:0016239)2.60401576
96drug transmembrane transport (GO:0006855)2.60298155
97regulation of protein activation cascade (GO:2000257)2.57557797
98growth hormone receptor signaling pathway (GO:0060396)2.57410921
99tryptophan catabolic process (GO:0006569)2.56764487
100indole-containing compound catabolic process (GO:0042436)2.56764487
101indolalkylamine catabolic process (GO:0046218)2.56764487
102positive regulation of lipid catabolic process (GO:0050996)2.56558660
103regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.56107818
104serine family amino acid catabolic process (GO:0009071)2.55429616
105peptidyl-lysine trimethylation (GO:0018023)2.55399944
106cellular modified amino acid catabolic process (GO:0042219)2.55071019
107detection of other organism (GO:0098543)2.54422458
108regulation of macrophage cytokine production (GO:0010935)2.54343965
109positive regulation of fibroblast migration (GO:0010763)2.54018772
110positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.53128292
111neutrophil activation (GO:0042119)2.52435045
112cellular potassium ion homeostasis (GO:0030007)2.52091380
113positive regulation of fatty acid beta-oxidation (GO:0032000)2.51403324
1142-oxoglutarate metabolic process (GO:0006103)2.50835419
115complement activation, alternative pathway (GO:0006957)2.50171808
116cerebellar Purkinje cell differentiation (GO:0021702)2.49648909
117interleukin-6-mediated signaling pathway (GO:0070102)2.49516384
118NLS-bearing protein import into nucleus (GO:0006607)2.49412916
119phospholipid homeostasis (GO:0055091)2.49281479
120regulation of fibrinolysis (GO:0051917)2.47784291
121positive regulation of macrophage cytokine production (GO:0060907)2.47192751
122regulation of interleukin-6 biosynthetic process (GO:0045408)2.47185711
123glucocorticoid receptor signaling pathway (GO:0042921)2.46076094
124tryptophan metabolic process (GO:0006568)2.45056421
125establishment of nucleus localization (GO:0040023)2.44031013
126positive regulation of mast cell activation (GO:0033005)2.43421566
127high-density lipoprotein particle remodeling (GO:0034375)2.42766938
128cellular sodium ion homeostasis (GO:0006883)2.42301450
129regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.42277412
130regulation of mast cell activation (GO:0033003)2.42250241
131histone H3-K36 demethylation (GO:0070544)2.41534284
132myelin assembly (GO:0032288)2.41526521
133vesicle transport along microtubule (GO:0047496)2.40234353
134regulation of protein glycosylation (GO:0060049)2.40113227
135regulation of complement activation (GO:0030449)2.39997389
136negative regulation of neurotransmitter secretion (GO:0046929)2.39454776
137protein K11-linked deubiquitination (GO:0035871)2.39194812
138regulation of RNA export from nucleus (GO:0046831)2.38909831
139regulation of cAMP-dependent protein kinase activity (GO:2000479)2.38813919
140regulation of MHC class II biosynthetic process (GO:0045346)2.38431642
141regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.38115783
142import into cell (GO:0098657)2.37455281
143positive regulation of cardiac muscle hypertrophy (GO:0010613)2.36945752
144positive regulation of muscle hypertrophy (GO:0014742)2.36945752
145regulation of protein polyubiquitination (GO:1902914)2.36639784
146positive regulation of insulin receptor signaling pathway (GO:0046628)2.36374073
147Golgi to endosome transport (GO:0006895)2.35479734
148COPII vesicle coating (GO:0048208)2.35076721
149regulation of synaptic vesicle exocytosis (GO:2000300)2.34443042
150synaptic vesicle docking involved in exocytosis (GO:0016081)2.34290389
151negative regulation of sterol transport (GO:0032372)2.33169995
152negative regulation of cholesterol transport (GO:0032375)2.33169995
153clathrin coat assembly (GO:0048268)2.33160941
154protein-lipid complex assembly (GO:0065005)2.33055176
155epoxygenase P450 pathway (GO:0019373)2.32648433
156embryonic process involved in female pregnancy (GO:0060136)2.32234770
157negative regulation of B cell proliferation (GO:0030889)2.32188272
158production of molecular mediator involved in inflammatory response (GO:0002532)2.31798108
159cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.31481618
160positive regulation of glycolytic process (GO:0045821)2.31294642
161positive regulation of interferon-alpha production (GO:0032727)2.30606305
162layer formation in cerebral cortex (GO:0021819)2.30302628
163synaptic vesicle exocytosis (GO:0016079)2.30235529
164amino-acid betaine metabolic process (GO:0006577)2.29729864
165positive regulation of histone deacetylation (GO:0031065)2.29235361
166bile acid metabolic process (GO:0008206)2.29089011
167negative regulation of interleukin-17 production (GO:0032700)2.28422706
168cellular response to ethanol (GO:0071361)2.28076349
169peptidyl-threonine phosphorylation (GO:0018107)2.27327601
170negative regulation of sodium ion transport (GO:0010766)2.27306766
171histone H3-K4 trimethylation (GO:0080182)2.27238249
172negative regulation of cell size (GO:0045792)2.26494879
173regulation of nucleobase-containing compound transport (GO:0032239)2.26322715
174protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.26197520
175plasma lipoprotein particle assembly (GO:0034377)2.25438573
176granulocyte activation (GO:0036230)2.25134489
177negative regulation of lipid transport (GO:0032369)2.24943017
178proline transport (GO:0015824)2.24200759
179endoplasmic reticulum organization (GO:0007029)2.23930653
180homocysteine metabolic process (GO:0050667)2.23682017
181negative regulation of protein activation cascade (GO:2000258)2.23225644
182UDP-N-acetylglucosamine metabolic process (GO:0006047)2.23149815
183dosage compensation (GO:0007549)2.23103836
184lipid translocation (GO:0034204)2.22609330
185phospholipid translocation (GO:0045332)2.22609330
186regulation of synaptic vesicle transport (GO:1902803)2.21998789
187positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.21993888
188Golgi transport vesicle coating (GO:0048200)2.21691219
189COPI coating of Golgi vesicle (GO:0048205)2.21691219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.05873535
2POU3F2_20337985_ChIP-ChIP_501MEL_Human2.97094613
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.93700636
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.93636668
5LXR_22158963_ChIP-Seq_LIVER_Mouse2.68879523
6EZH2_22144423_ChIP-Seq_EOC_Human2.54577442
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.46211790
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.44060408
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.37151407
10* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.01913805
11TAF15_26573619_Chip-Seq_HEK293_Human1.99458564
12SMAD_19615063_ChIP-ChIP_OVARY_Human1.98227201
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91980483
14ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91034515
15FLI1_27457419_Chip-Seq_LIVER_Mouse1.90403552
16ZNF217_24962896_ChIP-Seq_MCF-7_Human1.87983911
17SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80055733
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79407809
19GATA1_22025678_ChIP-Seq_K562_Human1.79220743
20IRF8_27001747_Chip-Seq_BMDM_Mouse1.76219237
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.73242334
22TP53_16413492_ChIP-PET_HCT116_Human1.73185612
23OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71487128
24* FOXA2_19822575_ChIP-Seq_HepG2_Human1.69433267
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.67276324
26P300_19829295_ChIP-Seq_ESCs_Human1.65508092
27* EZH2_27294783_Chip-Seq_NPCs_Mouse1.63204319
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.61427948
29MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61310882
30CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.61089459
31* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59350080
32CLOCK_20551151_ChIP-Seq_293T_Human1.58837188
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56853745
34TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.56751540
35FUS_26573619_Chip-Seq_HEK293_Human1.56613877
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55250148
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55076072
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54989096
39* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52924284
40ER_23166858_ChIP-Seq_MCF-7_Human1.52576950
41IGF1R_20145208_ChIP-Seq_DFB_Human1.52548668
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.52163343
43* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.52156007
44ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.48067521
45NANOG_18555785_Chip-Seq_ESCs_Mouse1.47782807
46VDR_24787735_ChIP-Seq_THP-1_Human1.47208489
47PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46496813
48* BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46349732
49TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44725442
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.44035252
51* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.43595612
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43306276
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41728390
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.40960069
55WT1_19549856_ChIP-ChIP_CCG9911_Human1.40440365
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.39727470
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.38525153
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38020777
59* BRD4_25478319_ChIP-Seq_HGPS_Human1.36989656
60E2F1_18555785_Chip-Seq_ESCs_Mouse1.36626146
61CMYC_18555785_Chip-Seq_ESCs_Mouse1.33596454
62AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32981983
63GBX2_23144817_ChIP-Seq_PC3_Human1.32303483
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31959950
65* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31845946
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31736181
67DROSHA_22980978_ChIP-Seq_HELA_Human1.31706974
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.31133950
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31120715
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30926716
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30691623
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.28921452
73AHR_22903824_ChIP-Seq_MCF-7_Human1.28667968
74* CRX_20693478_ChIP-Seq_RETINA_Mouse1.28286128
75TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.27815265
76* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.27287162
77* FLI1_21867929_ChIP-Seq_TH2_Mouse1.27181206
78SUZ12_18555785_Chip-Seq_ESCs_Mouse1.26319500
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.25706680
80P53_22387025_ChIP-Seq_ESCs_Mouse1.25393909
81EWS_26573619_Chip-Seq_HEK293_Human1.25135491
82SMAD4_21799915_ChIP-Seq_A2780_Human1.24867610
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24034576
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23713406
85* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22971504
86IRF8_22096565_ChIP-ChIP_GC-B_Human1.22546735
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22013499
88CBP_20019798_ChIP-Seq_JUKART_Human1.22013499
89ESR1_20079471_ChIP-ChIP_T-47D_Human1.21945802
90MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21545764
91RXR_22108803_ChIP-Seq_LS180_Human1.21050587
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.20657045
93* BCAT_22108803_ChIP-Seq_LS180_Human1.19918884
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18791969
95NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18791969
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18353435
97P300_18555785_Chip-Seq_ESCs_Mouse1.16690817
98ZNF263_19887448_ChIP-Seq_K562_Human1.16524834
99ZNF274_21170338_ChIP-Seq_K562_Hela1.16094358
100* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.15687336
101* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.14729301
102STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.14304029
103PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14213962
104SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13466810
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.13348064
106SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13024598
107TCF7_22412390_ChIP-Seq_EML_Mouse1.12157326
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12001179
109SALL4_22934838_ChIP-ChIP_CD34+_Human1.11760817
110STAT3_23295773_ChIP-Seq_U87_Human1.11444456
111EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11109838
112CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10940617
113KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10567146
114NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10467573
115* CDX2_22108803_ChIP-Seq_LS180_Human1.10216892
116AR_21572438_ChIP-Seq_LNCaP_Human1.10119056
117SOX2_21211035_ChIP-Seq_LN229_Gbm1.09892397
118FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09272078
119OCT4_18555785_Chip-Seq_ESCs_Mouse1.08771800
120NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08270331
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08081851
122RUNX_20019798_ChIP-Seq_JUKART_Human1.07945636
123NMYC_18555785_Chip-Seq_ESCs_Mouse1.07849635
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05097752
125SOX2_18555785_Chip-Seq_ESCs_Mouse1.05027863
126PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04757924
127MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04737489
128TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04102487
129AR_19668381_ChIP-Seq_PC3_Human1.04010958
130PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04002938
131IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03277658
132SALL1_21062744_ChIP-ChIP_HESCs_Human1.02624470
133KDM2B_26808549_Chip-Seq_K562_Human1.02623877
134P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01231264
135KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01118137
136ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00816752
137EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99822890
138KDM2B_26808549_Chip-Seq_DND41_Human0.99708046
139AR_25329375_ChIP-Seq_VCAP_Human0.99058931
140TRIM28_21343339_ChIP-Seq_HEK293_Human0.98652373
141EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97495194
142ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97208250
143WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96359310
144GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96267788
145MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95116486
146TCF4_23295773_ChIP-Seq_U87_Human0.92158854
147KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92037505
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91852884
149* HNF4A_19822575_ChIP-Seq_HepG2_Human0.91572584
150ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91310038
151TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90702144
152SPI1_23127762_ChIP-Seq_K562_Human0.90134071
153FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.89591693
154KDM2B_26808549_Chip-Seq_JURKAT_Human0.89565880
155SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88837688
156* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88694233
157AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88604214
158* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88580665
159RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88297644
160SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87279348
161* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86726126
162SMAD4_21741376_ChIP-Seq_HESCs_Human0.86680166
163KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86573063

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.68577876
2MP0008057_abnormal_DNA_replication4.71231733
3MP0005360_urolithiasis4.25081896
4MP0000569_abnormal_digit_pigmentation3.95584381
5MP0005365_abnormal_bile_salt3.65698460
6MP0004859_abnormal_synaptic_plasticity3.59036440
7MP0005085_abnormal_gallbladder_physiolo3.55462180
8MP0003300_gastrointestinal_ulcer3.02126686
9MP0003252_abnormal_bile_duct2.94680163
10MP0008875_abnormal_xenobiotic_pharmacok2.86592336
11MP0003221_abnormal_cardiomyocyte_apopto2.65893115
12MP0010329_abnormal_lipoprotein_level2.50948252
13MP0002138_abnormal_hepatobiliary_system2.42704065
14MP0003724_increased_susceptibility_to2.42287951
15MP0009780_abnormal_chondrocyte_physiolo2.40122477
16MP0005083_abnormal_biliary_tract2.39479293
17MP0010234_abnormal_vibrissa_follicle2.32255943
18MP0003705_abnormal_hypodermis_morpholog2.26560020
19MP0008260_abnormal_autophagy2.16292217
20MP0008961_abnormal_basal_metabolism2.09626710
21MP0003329_amyloid_beta_deposits2.09318013
22MP0001835_abnormal_antigen_presentation2.02359286
23MP0000604_amyloidosis2.00993280
24MP0002909_abnormal_adrenal_gland1.91779669
25MP0003828_pulmonary_edema1.86890580
26MP0008877_abnormal_DNA_methylation1.84845498
27MP0002009_preneoplasia1.84599437
28MP0006054_spinal_hemorrhage1.83219144
29MP0003183_abnormal_peptide_metabolism1.80929008
30MP0003635_abnormal_synaptic_transmissio1.73027925
31MP0003890_abnormal_embryonic-extraembry1.72878040
32MP0005451_abnormal_body_composition1.69783107
33MP0010352_gastrointestinal_tract_polyps1.62665641
34MP0003950_abnormal_plasma_membrane1.57830268
35MP0002928_abnormal_bile_duct1.57563142
36MP0002332_abnormal_exercise_endurance1.56469289
37MP0000015_abnormal_ear_pigmentation1.56028304
38MP0004270_analgesia1.52773382
39MP0002735_abnormal_chemical_nociception1.47442379
40MP0006082_CNS_inflammation1.46868232
41MP0001958_emphysema1.46274738
42MP0005332_abnormal_amino_acid1.46163139
43MP0002006_tumorigenesis1.46020242
44MP0002063_abnormal_learning/memory/cond1.45483386
45MP0002254_reproductive_system_inflammat1.42657714
46MP0003045_fibrosis1.40444450
47MP0002419_abnormal_innate_immunity1.40249924
48MP0000609_abnormal_liver_physiology1.39871182
49MP0003303_peritoneal_inflammation1.37895891
50MP0002118_abnormal_lipid_homeostasis1.34648620
51MP0002877_abnormal_melanocyte_morpholog1.32750404
52MP0000371_diluted_coat_color1.31247696
53MP0003091_abnormal_cell_migration1.31030656
54MP0005174_abnormal_tail_pigmentation1.30758068
55MP0005076_abnormal_cell_differentiation1.30222226
56MP0001968_abnormal_touch/_nociception1.28480002
57MP0001177_atelectasis1.23859246
58MP0001666_abnormal_nutrient_absorption1.22750060
59MP0004858_abnormal_nervous_system1.19026852
60MP0004130_abnormal_muscle_cell1.15429564
61MP0003195_calcinosis1.15082083
62MP0009840_abnormal_foam_cell1.13419375
63MP0005248_abnormal_Harderian_gland1.11607829
64MP0003787_abnormal_imprinting1.10273627
65MP0009745_abnormal_behavioral_response1.09448368
66MP0005319_abnormal_enzyme/_coenzyme1.08925194
67MP0001440_abnormal_grooming_behavior1.08599333
68MP0005408_hypopigmentation1.07784142
69MP0003868_abnormal_feces_composition1.06733904
70MP0005310_abnormal_salivary_gland1.03804170
71MP0001501_abnormal_sleep_pattern1.03005649
72MP0004484_altered_response_of1.02258275
73MP0003566_abnormal_cell_adhesion1.01017317
74MP0005075_abnormal_melanosome_morpholog1.00101371
75MP0004808_abnormal_hematopoietic_stem0.98482842
76MP0005621_abnormal_cell_physiology0.98120155
77MP0003690_abnormal_glial_cell0.97802857
78MP0001299_abnormal_eye_distance/0.96393219
79MP0003191_abnormal_cellular_cholesterol0.96118125
80MP0009785_altered_susceptibility_to0.95561725
81MP0001800_abnormal_humoral_immune0.94189122
82MP0002090_abnormal_vision0.93938559
83MP0002168_other_aberrant_phenotype0.92634029
84MP0001765_abnormal_ion_homeostasis0.92604073
85MP0008874_decreased_physiological_sensi0.92095386
86MP0004811_abnormal_neuron_physiology0.91915377
87MP0005058_abnormal_lysosome_morphology0.90825978
88MP0005000_abnormal_immune_tolerance0.90810501
89MP0010307_abnormal_tumor_latency0.90710988
90MP0002396_abnormal_hematopoietic_system0.90577783
91MP0003172_abnormal_lysosome_physiology0.89179452
92MP0005166_decreased_susceptibility_to0.88214302
93MP0005367_renal/urinary_system_phenotyp0.87238756
94MP0000516_abnormal_urinary_system0.87238756
95MP0001915_intracranial_hemorrhage0.87051354
96MP0005266_abnormal_metabolism0.86936574
97MP0002452_abnormal_antigen_presenting0.86325604
98MP0002064_seizures0.85322551
99MP0002723_abnormal_immune_serum0.84876882
100MP0005584_abnormal_enzyme/coenzyme_acti0.84526567
101MP0002736_abnormal_nociception_after0.83645105
102MP0004233_abnormal_muscle_weight0.83379065
103MP0001851_eye_inflammation0.81973858
104MP0003075_altered_response_to0.81966044
105MP0003633_abnormal_nervous_system0.81957415
106MP0005647_abnormal_sex_gland0.81745831
107MP0002166_altered_tumor_susceptibility0.81025395
108MP0000598_abnormal_liver_morphology0.79976116
109MP0009046_muscle_twitch0.79961768
110MP0010678_abnormal_skin_adnexa0.79711274
111MP0004883_abnormal_blood_vessel0.78732798
112MP0002089_abnormal_postnatal_growth/wei0.77954591
113MP0003656_abnormal_erythrocyte_physiolo0.77021892
114MP0003448_altered_tumor_morphology0.76827825
115MP0002572_abnormal_emotion/affect_behav0.75930954
116MP0004510_myositis0.75471492
117MP0000920_abnormal_myelination0.74472693
118MP0005023_abnormal_wound_healing0.74426801
119MP0005535_abnormal_body_temperature0.74365332
120MP0005084_abnormal_gallbladder_morpholo0.74302460
121MP0004134_abnormal_chest_morphology0.73652452
122MP0001756_abnormal_urination0.72618354
123MP0002733_abnormal_thermal_nociception0.72583537
124MP0005384_cellular_phenotype0.72364331
125MP0005395_other_phenotype0.71493492
126MP0002420_abnormal_adaptive_immunity0.71083591
127MP0001819_abnormal_immune_cell0.70373265
128MP0002822_catalepsy0.68919722
129MP0001845_abnormal_inflammatory_respons0.68307968
130MP0004019_abnormal_vitamin_homeostasis0.68277414
131MP0010368_abnormal_lymphatic_system0.67231050
132MP0004185_abnormal_adipocyte_glucose0.65394193
133MP0008004_abnormal_stomach_pH0.65215481
134MP0000465_gastrointestinal_hemorrhage0.65043288
135MP0005334_abnormal_fat_pad0.64878380
136MP0002398_abnormal_bone_marrow0.64540082
137MP0005464_abnormal_platelet_physiology0.63834831
138MP0009115_abnormal_fat_cell0.63751746
139MP0002269_muscular_atrophy0.63676378
140MP0000689_abnormal_spleen_morphology0.63481281
141MP0005397_hematopoietic_system_phenotyp0.63451715
142MP0001545_abnormal_hematopoietic_system0.63451715
143MP0002078_abnormal_glucose_homeostasis0.63116646
144MP0003436_decreased_susceptibility_to0.62916544
145MP0009763_increased_sensitivity_to0.62716704
146MP0009643_abnormal_urine_homeostasis0.62516581
147MP0004947_skin_inflammation0.62507477
148MP0001881_abnormal_mammary_gland0.62260526
149MP0000427_abnormal_hair_cycle0.61895415
150MP0001533_abnormal_skeleton_physiology0.61756282
151MP0004264_abnormal_extraembryonic_tissu0.60766040
152MP0003806_abnormal_nucleotide_metabolis0.60566221
153MP0009764_decreased_sensitivity_to0.58761871
154MP0009697_abnormal_copulation0.56687792
155MP0002734_abnormal_mechanical_nocicepti0.56033611
156MP0002896_abnormal_bone_mineralization0.55856322
157MP0004782_abnormal_surfactant_physiolog0.55815708
158MP0004885_abnormal_endolymph0.55339297
159MP0002998_abnormal_bone_remodeling0.55257437
160MP0003631_nervous_system_phenotype0.54476149
161MP0005164_abnormal_response_to0.54318600
162MP0000013_abnormal_adipose_tissue0.53937604
163MP0009384_cardiac_valve_regurgitation0.53153494
164MP0005666_abnormal_adipose_tissue0.51010529
165MP0009672_abnormal_birth_weight0.50430239

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)4.56710219
2Fair hair (HP:0002286)3.62894043
3Deep venous thrombosis (HP:0002625)3.59582697
4Long clavicles (HP:0000890)3.14072861
5Volvulus (HP:0002580)3.11123577
6Thyroid carcinoma (HP:0002890)3.07406033
7Abnormality of the lower motor neuron (HP:0002366)3.01230992
8Medulloblastoma (HP:0002885)2.95299755
9Intrahepatic cholestasis (HP:0001406)2.90877495
10Abnormality of the common coagulation pathway (HP:0010990)2.90584193
11Generalized hypopigmentation of hair (HP:0011358)2.87504204
12Xanthomatosis (HP:0000991)2.86783148
13Abnormality of monocarboxylic acid metabolism (HP:0010996)2.83406094
14Absent frontal sinuses (HP:0002688)2.77266096
15Dysmetric saccades (HP:0000641)2.75707975
16Gout (HP:0001997)2.74840475
17Recurrent bacterial skin infections (HP:0005406)2.70588746
18Gingival bleeding (HP:0000225)2.69661518
19Retrobulbar optic neuritis (HP:0100654)2.62437458
20Optic neuritis (HP:0100653)2.62437458
21Aortic aneurysm (HP:0004942)2.59943618
22Macroorchidism (HP:0000053)2.54654995
23Abnormality of the labia minora (HP:0012880)2.51623196
24Abnormal hair whorl (HP:0010721)2.51171797
25Long toe (HP:0010511)2.50022803
26Hypobetalipoproteinemia (HP:0003563)2.49741094
27Recurrent abscess formation (HP:0002722)2.49447044
28Abnormality of glutamine family amino acid metabolism (HP:0010902)2.46018067
29Inappropriate behavior (HP:0000719)2.45980434
30Focal seizures (HP:0007359)2.45283631
31T lymphocytopenia (HP:0005403)2.44514450
32Curly hair (HP:0002212)2.42901614
33Focal motor seizures (HP:0011153)2.40288097
34Global brain atrophy (HP:0002283)2.39867845
35Disinhibition (HP:0000734)2.38522064
36Skin nodule (HP:0200036)2.37628576
37Febrile seizures (HP:0002373)2.36824150
38Papilledema (HP:0001085)2.35461337
39Action tremor (HP:0002345)2.34912197
40Impaired social interactions (HP:0000735)2.34560132
41Abnormal social behavior (HP:0012433)2.34560132
42Amyotrophic lateral sclerosis (HP:0007354)2.31911517
43Mitral stenosis (HP:0001718)2.31620832
44Lower limb hyperreflexia (HP:0002395)2.31358587
45Periodontitis (HP:0000704)2.31057027
46Hepatoblastoma (HP:0002884)2.29541067
47Abnormality of T cell number (HP:0011839)2.28769473
48Hyperlipoproteinemia (HP:0010980)2.28329544
49Acute myeloid leukemia (HP:0004808)2.25594633
50Autoamputation (HP:0001218)2.22310925
51Epidermoid cyst (HP:0200040)2.20911047
52Abnormality of aromatic amino acid family metabolism (HP:0004338)2.20402322
53Orchitis (HP:0100796)2.15884000
54Genetic anticipation (HP:0003743)2.14063780
55Arterial thrombosis (HP:0004420)2.12721595
56Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.12592808
57Short 1st metacarpal (HP:0010034)2.12592808
58Mitral valve prolapse (HP:0001634)2.11887187
59Complement deficiency (HP:0004431)2.10934431
60Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.09733338
61Hypolipoproteinemia (HP:0010981)2.08802539
62Hypoalphalipoproteinemia (HP:0003233)2.08624502
63Hyperventilation (HP:0002883)2.07863152
64Aneurysm (HP:0002617)2.05147670
65Myocardial infarction (HP:0001658)2.04586235
66Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.04562690
67Degeneration of the lateral corticospinal tracts (HP:0002314)2.04562690
68Abnormality of sulfur amino acid metabolism (HP:0004339)2.02881103
69Sensorimotor neuropathy (HP:0007141)2.02302679
70Status epilepticus (HP:0002133)2.01583045
71Progressive inability to walk (HP:0002505)1.99237221
72Fatigue (HP:0012378)1.98478331
73Facial diplegia (HP:0001349)1.98455881
74Aplasia/Hypoplasia of the sternum (HP:0006714)1.97607852
75Cystic hygroma (HP:0000476)1.97116250
76Deep philtrum (HP:0002002)1.96984006
77Cerebral aneurysm (HP:0004944)1.96064871
78Truncal obesity (HP:0001956)1.95856237
79Resting tremor (HP:0002322)1.95085561
80Progressive cerebellar ataxia (HP:0002073)1.94958044
81Increased mean platelet volume (HP:0011877)1.94948546
82Abnormality of purine metabolism (HP:0004352)1.94819086
83Abnormality of the vasculature of the conjunctiva (HP:0008054)1.92926607
84Agnosia (HP:0010524)1.92890480
85Heterotopia (HP:0002282)1.92563934
86Impaired smooth pursuit (HP:0007772)1.91823890
87Hypoplastic labia majora (HP:0000059)1.90351879
88Abnormality of the Achilles tendon (HP:0005109)1.89149178
89Upper limb amyotrophy (HP:0009129)1.88342760
90Distal upper limb amyotrophy (HP:0007149)1.88342760
91Recurrent gram-negative bacterial infections (HP:0005420)1.86749087
92Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.86388778
93Increased density of long bones (HP:0006392)1.85473487
94Tetraparesis (HP:0002273)1.85425635
95Ketosis (HP:0001946)1.85197818
96Impaired vibratory sensation (HP:0002495)1.84851591
97Keratoconjunctivitis sicca (HP:0001097)1.84625832
98Narrow palate (HP:0000189)1.84280758
99Hand muscle atrophy (HP:0009130)1.83934791
100Broad ribs (HP:0000885)1.82989885
101Scanning speech (HP:0002168)1.82790725
102Arterial tortuosity (HP:0005116)1.82351125
103Prominent nose (HP:0000448)1.81266109
104Hypercholesterolemia (HP:0003124)1.81260950
105Abnormality of ocular smooth pursuit (HP:0000617)1.81131941
106Lower limb muscle weakness (HP:0007340)1.80886009
107Prolonged partial thromboplastin time (HP:0003645)1.80275321
108Impaired vibration sensation in the lower limbs (HP:0002166)1.80252377
109Striae distensae (HP:0001065)1.80208018
110Keratoconjunctivitis (HP:0001096)1.79611094
111Myositis (HP:0100614)1.79555326
112Urinary bladder sphincter dysfunction (HP:0002839)1.78736249
113Excessive salivation (HP:0003781)1.78695741
114Drooling (HP:0002307)1.78695741
115Poor eye contact (HP:0000817)1.78624031
116Short phalanx of the thumb (HP:0009660)1.78491436
117Hypochromic microcytic anemia (HP:0004840)1.78398630
118Gingivitis (HP:0000230)1.77555966
119Submucous cleft hard palate (HP:0000176)1.77278754
120Conjunctival telangiectasia (HP:0000524)1.77230686
121Acanthocytosis (HP:0001927)1.76467899
122Abnormality of the musculature of the pelvis (HP:0001469)1.76425165
123Abnormality of the hip-girdle musculature (HP:0001445)1.76425165
124Spondylolisthesis (HP:0003302)1.76177656
125Atonic seizures (HP:0010819)1.75759473
126Subaortic stenosis (HP:0001682)1.75631294
127Abnormality of the left ventricular outflow tract (HP:0011103)1.75631294
128Transitional cell carcinoma of the bladder (HP:0006740)1.75573466
129Urinary urgency (HP:0000012)1.74999105
130Subacute progressive viral hepatitis (HP:0006572)1.74639231
131Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.74598862
132Pelvic girdle muscle weakness (HP:0003749)1.74283648
133Hemiplegia (HP:0002301)1.74053941
134Aqueductal stenosis (HP:0002410)1.73978090
135Rhabdomyosarcoma (HP:0002859)1.73910589
136Postural instability (HP:0002172)1.73591401
137Spontaneous abortion (HP:0005268)1.72565553
138Abnormality of proline metabolism (HP:0010907)1.72223568
139Hydroxyprolinuria (HP:0003080)1.72223568
140Dilatation of the ascending aorta (HP:0005111)1.71934579
141Eczematoid dermatitis (HP:0000976)1.71783404
142Myokymia (HP:0002411)1.71382173
143Protuberant abdomen (HP:0001538)1.71295137
144Spontaneous hematomas (HP:0007420)1.71279377
145Abnormality of the intrinsic pathway (HP:0010989)1.70886622
146Absent speech (HP:0001344)1.70711482
147Bladder neoplasm (HP:0009725)1.70078251
148Bladder carcinoma (HP:0002862)1.70078251
149Stomatitis (HP:0010280)1.70077160
150Abnormality of the 1st metacarpal (HP:0010009)1.69669242
151Widely spaced teeth (HP:0000687)1.69447672
152Rectal prolapse (HP:0002035)1.69397969
153Abnormality of the labia majora (HP:0012881)1.68912231
154Protruding tongue (HP:0010808)1.68449011
155Menstrual irregularities (HP:0000858)1.68054037
156Difficulty running (HP:0009046)1.67790989
157Decreased skull ossification (HP:0004331)1.67702238
158Absence seizures (HP:0002121)1.67104941
159Termporal pattern (HP:0011008)1.66871049
160Insidious onset (HP:0003587)1.66871049
161Visual hallucinations (HP:0002367)1.65952817
162Abnormal platelet volume (HP:0011876)1.65605492
163Relative macrocephaly (HP:0004482)1.65220150
164Increased purine levels (HP:0004368)1.64940843
165Hyperuricemia (HP:0002149)1.64940843
166Lymphangioma (HP:0100764)1.64243893
167Frequent falls (HP:0002359)1.64157826
168Pulmonary embolism (HP:0002204)1.62440968
169Vascular tortuosity (HP:0004948)1.62099385
170Neonatal onset (HP:0003623)1.61372931
171Obsessive-compulsive behavior (HP:0000722)1.61217803
172Joint hemorrhage (HP:0005261)1.60397794
173Enlarged penis (HP:0000040)1.57364920
174Spinal cord lesions (HP:0100561)1.57177880
175Syringomyelia (HP:0003396)1.57177880
176Esophageal varix (HP:0002040)1.56327942
177Abnormality of the thoracic spine (HP:0100711)1.55969128
178Achilles tendon contracture (HP:0001771)1.55515033
179Gaze-evoked nystagmus (HP:0000640)1.55506615

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.46954018
2PINK13.29342004
3ACVR1B2.85798770
4AKT32.76969045
5EIF2AK32.75557741
6RIPK42.46614797
7FRK2.35968921
8NTRK32.26652820
9LMTK22.24474001
10BMPR22.24255566
11TRIM282.18675877
12CAMK1G2.09628071
13MAP3K42.06815094
14RIPK12.01385237
15ERBB32.00238192
16DAPK21.93247005
17TAOK31.90571933
18FGFR21.85123749
19CAMK1D1.84312008
20BCR1.76844598
21SCYL21.75668217
22KSR21.75466814
23CAMKK11.74099917
24TRIB31.72960474
25MAP2K41.71774081
26FGFR41.71103826
27PKN21.68313208
28MAP4K21.67725783
29EPHA41.64604150
30MINK11.63525776
31KSR11.62649328
32TAOK11.60746014
33CAMKK21.60489860
34PRKD31.53673490
35STK31.52250191
36BLK1.47272237
37STK381.45773433
38IRAK11.43331059
39YES11.41996679
40RET1.40923426
41MAP3K141.40636408
42SGK31.38634523
43IRAK21.37292312
44CDK61.34370383
45FGFR31.33888105
46PDGFRA1.32019786
47TNIK1.28809992
48BRD41.28385258
49MAP3K21.27810052
50SIK31.26085077
51SIK11.25906654
52PTK2B1.24929713
53FGR1.20352423
54NTRK11.19063396
55MAP3K131.18795035
56MAP3K61.12571641
57DMPK1.11887238
58TYK21.10232773
59MAP3K71.08942123
60PTK21.08461002
61MAP3K121.07954301
62LATS11.07343526
63SGK4941.07287233
64SGK2231.07287233
65PBK1.04548944
66PAK61.00839992
67EIF2AK11.00322354
68LATS20.97931472
69PDGFRB0.97714329
70NEK60.97579484
71JAK10.97512749
72FGFR10.97084815
73TRPM70.96404789
74STK240.91953865
75MAP2K30.91356133
76SGK20.90834058
77PDK10.89449926
78FER0.89103507
79SIK20.89033157
80PTK60.88141464
81ERN10.86045236
82MST40.85501787
83NLK0.85443278
84EEF2K0.85386680
85DAPK10.84289303
86TESK10.83483105
87TEC0.83083128
88TTN0.80805031
89PNCK0.78245041
90PRKCH0.78023109
91ALK0.77382426
92OBSCN0.77365919
93MAPK130.76522080
94MAP3K30.75183828
95TYRO30.72996936
96CDK120.72873872
97PDK30.72656287
98PDK40.72656287
99BRSK20.72258480
100TGFBR20.71887205
101CDK50.69491728
102PAK30.69205405
103MTOR0.69130734
104PDPK10.68861794
105NEK10.68610762
106STK38L0.67085299
107CSK0.66668141
108MAP3K50.66514402
109MAP2K70.65991593
110WNK30.65976060
111PLK20.63606302
112MARK30.63457055
113RAF10.63445172
114DYRK30.63168395
115MAP3K10.62505241
116HCK0.61545258
117LRRK20.60267998
118JAK20.59627724
119IKBKE0.59411634
120IRAK40.58680036
121INSRR0.58269000
122WNK10.57479269
123ZAP700.54496142
124RPS6KA40.53140143
125STK100.52391026
126CLK10.50933805
127TSSK60.50074107
128STK110.49685750
129ITK0.48829991
130PIK3CG0.47538966
131PRKAA20.47048053
132GRK60.47035623
133FYN0.46922020
134MELK0.46736321
135CSNK1A1L0.44643445
136SGK10.43968522
137PIM10.40870544
138EGFR0.40556882
139SRPK10.40182513
140CCNB10.39156174
141PRKCQ0.38964490
142SYK0.38803101
143MAPK100.38794283
144STK40.38415483
145DDR20.38372482
146EPHA30.38108189
147PRKCG0.38048656
148BRAF0.37316011
149TNK20.37220318
150CAMK10.36939372
151NEK90.35815766
152EIF2AK20.35385077
153JAK30.34770646
154FES0.34166265
155PRKCE0.33937974
156PRKG20.33936044
157CAMK40.32910556

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.62678661
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.67478881
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.27187912
4Arginine biosynthesis_Homo sapiens_hsa002202.16522005
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.05447000
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.91945394
7Legionellosis_Homo sapiens_hsa051341.82363551
8NOD-like receptor signaling pathway_Homo sapiens_hsa046211.78837408
9Osteoclast differentiation_Homo sapiens_hsa043801.68549592
10Long-term potentiation_Homo sapiens_hsa047201.63825907
11Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61978921
12Tuberculosis_Homo sapiens_hsa051521.61776661
13Bile secretion_Homo sapiens_hsa049761.61404785
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.57088819
15Leishmaniasis_Homo sapiens_hsa051401.54874116
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48351754
17Complement and coagulation cascades_Homo sapiens_hsa046101.40484680
18Prolactin signaling pathway_Homo sapiens_hsa049171.40372424
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38766103
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.34744528
21Measles_Homo sapiens_hsa051621.29674857
22Sphingolipid signaling pathway_Homo sapiens_hsa040711.29469971
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26281222
24FoxO signaling pathway_Homo sapiens_hsa040681.22428013
25Hepatitis B_Homo sapiens_hsa051611.21189113
26Renal cell carcinoma_Homo sapiens_hsa052111.21161424
27Caffeine metabolism_Homo sapiens_hsa002321.15400874
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14274462
29Glioma_Homo sapiens_hsa052141.14263605
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13327532
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12307799
32PPAR signaling pathway_Homo sapiens_hsa033201.10459555
33Prostate cancer_Homo sapiens_hsa052151.10174307
34Type II diabetes mellitus_Homo sapiens_hsa049301.10095703
35TNF signaling pathway_Homo sapiens_hsa046681.09007704
36Synaptic vesicle cycle_Homo sapiens_hsa047211.08128654
37B cell receptor signaling pathway_Homo sapiens_hsa046621.05715665
38Salivary secretion_Homo sapiens_hsa049701.05112609
39Non-homologous end-joining_Homo sapiens_hsa034501.04664848
40Amphetamine addiction_Homo sapiens_hsa050311.04654718
41Circadian rhythm_Homo sapiens_hsa047101.04009752
42Nicotine addiction_Homo sapiens_hsa050331.03576940
43Influenza A_Homo sapiens_hsa051641.02754722
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02599698
45Colorectal cancer_Homo sapiens_hsa052101.02572303
46Acute myeloid leukemia_Homo sapiens_hsa052211.02339742
47Regulation of autophagy_Homo sapiens_hsa041401.02199543
48Toxoplasmosis_Homo sapiens_hsa051451.01784219
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01646202
50Circadian entrainment_Homo sapiens_hsa047131.01591209
51Tryptophan metabolism_Homo sapiens_hsa003801.01367961
52mTOR signaling pathway_Homo sapiens_hsa041500.99338585
53Renin secretion_Homo sapiens_hsa049240.98446997
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97330233
55Fatty acid degradation_Homo sapiens_hsa000710.96430122
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93291521
57Chemokine signaling pathway_Homo sapiens_hsa040620.93193248
58Insulin secretion_Homo sapiens_hsa049110.92579190
59Glucagon signaling pathway_Homo sapiens_hsa049220.92360993
60Lysine degradation_Homo sapiens_hsa003100.91426097
61Gastric acid secretion_Homo sapiens_hsa049710.90504704
62Phagosome_Homo sapiens_hsa041450.89441028
63Dopaminergic synapse_Homo sapiens_hsa047280.87791004
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87612090
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86910176
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86611858
67Estrogen signaling pathway_Homo sapiens_hsa049150.85956358
68Insulin resistance_Homo sapiens_hsa049310.85761759
69Thyroid hormone synthesis_Homo sapiens_hsa049180.85464637
70Olfactory transduction_Homo sapiens_hsa047400.83810065
71Dorso-ventral axis formation_Homo sapiens_hsa043200.83607112
72T cell receptor signaling pathway_Homo sapiens_hsa046600.83109070
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.81569410
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80856288
75Oxytocin signaling pathway_Homo sapiens_hsa049210.77113085
76ABC transporters_Homo sapiens_hsa020100.76389405
77VEGF signaling pathway_Homo sapiens_hsa043700.76132712
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.75692862
79Starch and sucrose metabolism_Homo sapiens_hsa005000.75347239
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74610172
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74545090
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.74323690
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74100794
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73943636
85Glutamatergic synapse_Homo sapiens_hsa047240.73126968
86Selenocompound metabolism_Homo sapiens_hsa004500.71675876
87GnRH signaling pathway_Homo sapiens_hsa049120.71335004
88Systemic lupus erythematosus_Homo sapiens_hsa053220.70281049
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69408119
90Viral carcinogenesis_Homo sapiens_hsa052030.69373474
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68850336
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68840348
93Hepatitis C_Homo sapiens_hsa051600.68302005
94GABAergic synapse_Homo sapiens_hsa047270.68100911
95Insulin signaling pathway_Homo sapiens_hsa049100.67678295
96Non-small cell lung cancer_Homo sapiens_hsa052230.67278887
97Choline metabolism in cancer_Homo sapiens_hsa052310.67261979
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66904072
99Chronic myeloid leukemia_Homo sapiens_hsa052200.66184855
100Morphine addiction_Homo sapiens_hsa050320.66133012
101Cholinergic synapse_Homo sapiens_hsa047250.66071237
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64829299
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64700942
104MicroRNAs in cancer_Homo sapiens_hsa052060.64699589
105ErbB signaling pathway_Homo sapiens_hsa040120.64660087
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64655884
107Rheumatoid arthritis_Homo sapiens_hsa053230.64567898
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64393793
109Butanoate metabolism_Homo sapiens_hsa006500.63084116
110Shigellosis_Homo sapiens_hsa051310.62929353
111cAMP signaling pathway_Homo sapiens_hsa040240.62603052
112HIF-1 signaling pathway_Homo sapiens_hsa040660.62086430
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62015154
114Staphylococcus aureus infection_Homo sapiens_hsa051500.61656780
115Long-term depression_Homo sapiens_hsa047300.61609805
116Salmonella infection_Homo sapiens_hsa051320.61473999
117Sphingolipid metabolism_Homo sapiens_hsa006000.60399366
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59593955
119Propanoate metabolism_Homo sapiens_hsa006400.59560883
120African trypanosomiasis_Homo sapiens_hsa051430.59546051
121Proteoglycans in cancer_Homo sapiens_hsa052050.59423793
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59029717
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57724142
124Endometrial cancer_Homo sapiens_hsa052130.57112479
125Pyruvate metabolism_Homo sapiens_hsa006200.57043538
126Inositol phosphate metabolism_Homo sapiens_hsa005620.56813289
127Gap junction_Homo sapiens_hsa045400.56411115
128Glycerolipid metabolism_Homo sapiens_hsa005610.56211480
129Herpes simplex infection_Homo sapiens_hsa051680.55885208
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55366857
131AMPK signaling pathway_Homo sapiens_hsa041520.54904296
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54754136
133Alcoholism_Homo sapiens_hsa050340.54428160
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53761897
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53416771
136Pertussis_Homo sapiens_hsa051330.53075514
137Pancreatic cancer_Homo sapiens_hsa052120.53045024
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52739127
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.52590986
140Type I diabetes mellitus_Homo sapiens_hsa049400.52445791
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52013372
142Graft-versus-host disease_Homo sapiens_hsa053320.51675026
143Peroxisome_Homo sapiens_hsa041460.50965932
144Fatty acid biosynthesis_Homo sapiens_hsa000610.50769299
145Hematopoietic cell lineage_Homo sapiens_hsa046400.50446177
146Melanoma_Homo sapiens_hsa052180.50208904
147Focal adhesion_Homo sapiens_hsa045100.49711638
148Thyroid cancer_Homo sapiens_hsa052160.49647568
149Amoebiasis_Homo sapiens_hsa051460.49504775
150Phospholipase D signaling pathway_Homo sapiens_hsa040720.48990098
151Platelet activation_Homo sapiens_hsa046110.48972403
152Steroid hormone biosynthesis_Homo sapiens_hsa001400.48791669
153Adherens junction_Homo sapiens_hsa045200.48767943
154Malaria_Homo sapiens_hsa051440.48032167
155Fatty acid metabolism_Homo sapiens_hsa012120.47969523
156Cyanoamino acid metabolism_Homo sapiens_hsa004600.47682377
157Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47566978
158Endocytosis_Homo sapiens_hsa041440.45794964

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