UGT8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the UDP-glycosyltransferase family. It catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central and peripheral nervous systems. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.08426414
2central nervous system myelination (GO:0022010)8.08426414
3presynaptic membrane organization (GO:0097090)5.91388317
4locomotory exploration behavior (GO:0035641)4.87051676
5presynaptic membrane assembly (GO:0097105)4.85257892
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.70606883
7synaptic vesicle maturation (GO:0016188)4.56015395
8regulation of short-term neuronal synaptic plasticity (GO:0048172)4.37892460
9neuron cell-cell adhesion (GO:0007158)4.28594570
10L-amino acid import (GO:0043092)4.27254586
11glutamate secretion (GO:0014047)4.00118697
12cellular potassium ion homeostasis (GO:0030007)3.90309749
13long-chain fatty acid biosynthetic process (GO:0042759)3.82579726
14membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.65320781
15neurotransmitter uptake (GO:0001504)3.63763594
16ionotropic glutamate receptor signaling pathway (GO:0035235)3.61530136
17righting reflex (GO:0060013)3.55988478
18postsynaptic membrane organization (GO:0001941)3.53263868
19myelin maintenance (GO:0043217)3.51542898
20potassium ion import (GO:0010107)3.50012537
21amino acid import (GO:0043090)3.47722890
22exploration behavior (GO:0035640)3.44139261
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.44014780
24vocalization behavior (GO:0071625)3.40759786
25myelination (GO:0042552)3.34022443
26axon ensheathment (GO:0008366)3.32263670
27ensheathment of neurons (GO:0007272)3.32263670
28negative regulation of synaptic transmission, GABAergic (GO:0032229)3.28478512
29positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.26036179
30glutamate receptor signaling pathway (GO:0007215)3.24253295
31sodium ion export (GO:0071436)3.24072973
32regulation of synaptic vesicle exocytosis (GO:2000300)3.20885894
33synaptic transmission, glutamatergic (GO:0035249)3.18875197
34regulation of neuronal synaptic plasticity (GO:0048168)3.18825029
35neuronal ion channel clustering (GO:0045161)3.16821348
36neuronal action potential propagation (GO:0019227)3.15530914
37neurotransmitter secretion (GO:0007269)3.13895791
38potassium ion homeostasis (GO:0055075)3.11132052
39neuron-neuron synaptic transmission (GO:0007270)3.09312561
40synaptic vesicle exocytosis (GO:0016079)3.01867577
41long-term synaptic potentiation (GO:0060291)3.00808657
42detection of calcium ion (GO:0005513)2.95926667
43transmission of nerve impulse (GO:0019226)2.90330918
44substantia nigra development (GO:0021762)2.90257219
45C4-dicarboxylate transport (GO:0015740)2.89586908
46neurotransmitter transport (GO:0006836)2.86935275
47acidic amino acid transport (GO:0015800)2.84933187
48astrocyte development (GO:0014002)2.81552603
49oligodendrocyte differentiation (GO:0048709)2.81335997
50regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.81092585
51regulation of long-term neuronal synaptic plasticity (GO:0048169)2.79946536
52gamma-aminobutyric acid signaling pathway (GO:0007214)2.79887157
53positive regulation of neurological system process (GO:0031646)2.78474508
54proline transport (GO:0015824)2.77189965
55serotonin metabolic process (GO:0042428)2.73008775
56regulation of synaptic vesicle transport (GO:1902803)2.70185240
57cyclic nucleotide catabolic process (GO:0009214)2.69485886
58glycerophospholipid catabolic process (GO:0046475)2.68304734
59gamma-aminobutyric acid transport (GO:0015812)2.68145773
60peptidyl-cysteine modification (GO:0018198)2.63638039
61positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.62226988
62primary amino compound metabolic process (GO:1901160)2.62108563
63regulation of dendritic spine development (GO:0060998)2.61800799
64startle response (GO:0001964)2.60161335
65cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.60063769
66L-glutamate transport (GO:0015813)2.58956553
67regulation of female receptivity (GO:0045924)2.54002490
68regulation of neurotransmitter levels (GO:0001505)2.51762016
69astrocyte differentiation (GO:0048708)2.48969099
70regulation of excitatory postsynaptic membrane potential (GO:0060079)2.47886489
71dendritic spine morphogenesis (GO:0060997)2.47691996
72regulation of neurotransmitter uptake (GO:0051580)2.47454767
73membrane depolarization during action potential (GO:0086010)2.46885514
74G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.46753002
75cellular sodium ion homeostasis (GO:0006883)2.46194703
76neurotransmitter-gated ion channel clustering (GO:0072578)2.44092585
77negative regulation of cytosolic calcium ion concentration (GO:0051481)2.43117001
78regulation of synaptic plasticity (GO:0048167)2.42799492
79regulation of axon regeneration (GO:0048679)2.42554854
80regulation of neuron projection regeneration (GO:0070570)2.42554854
81regulation of neurotransmitter transport (GO:0051588)2.39558128
82negative regulation of dendrite morphogenesis (GO:0050774)2.38815687
83potassium ion transmembrane transport (GO:0071805)2.38716353
84cellular potassium ion transport (GO:0071804)2.38716353
85regulation of dendritic spine morphogenesis (GO:0061001)2.38441553
86membrane assembly (GO:0071709)2.38229168
87long term synaptic depression (GO:0060292)2.37686768
88cell communication involved in cardiac conduction (GO:0086065)2.36883061
89regulation of postsynaptic membrane potential (GO:0060078)2.36654080
90positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.36645147
91fucose catabolic process (GO:0019317)2.35592035
92L-fucose metabolic process (GO:0042354)2.35592035
93L-fucose catabolic process (GO:0042355)2.35592035
94potassium ion transport (GO:0006813)2.34815784
95negative regulation of dendrite development (GO:2000171)2.33856755
96atrial cardiac muscle cell action potential (GO:0086014)2.32680061
97adult walking behavior (GO:0007628)2.32166862
98positive regulation of membrane potential (GO:0045838)2.31940574
99positive regulation of dendritic spine development (GO:0060999)2.31557206
100positive regulation of meiosis (GO:0045836)2.31548124

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.72908654
2ZFP57_27257070_Chip-Seq_ESCs_Mouse2.62030741
3* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.58493751
4SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.39255739
5EZH2_22144423_ChIP-Seq_EOC_Human2.33800924
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.32875023
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32861256
8* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.28244003
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26251726
10P300_19829295_ChIP-Seq_ESCs_Human2.23752163
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.19495048
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.17945856
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17785956
14* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.14061526
15FUS_26573619_Chip-Seq_HEK293_Human2.11075040
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04356930
17REST_21632747_ChIP-Seq_MESCs_Mouse2.03464010
18SMAD4_21799915_ChIP-Seq_A2780_Human2.01210050
19TAF15_26573619_Chip-Seq_HEK293_Human1.92530025
20* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.92058016
21STAT3_23295773_ChIP-Seq_U87_Human1.87244068
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.86492924
23* PIAS1_25552417_ChIP-Seq_VCAP_Human1.84974898
24EWS_26573619_Chip-Seq_HEK293_Human1.83276991
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.82858564
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80398403
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78243763
28TCF4_23295773_ChIP-Seq_U87_Human1.76334672
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74982867
30SMAD3_21741376_ChIP-Seq_EPCs_Human1.69687579
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68365017
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63769805
33* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.63216969
34VDR_22108803_ChIP-Seq_LS180_Human1.62691832
35TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.57183832
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54483011
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54024261
38TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51310022
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.49978094
40NANOG_18555785_Chip-Seq_ESCs_Mouse1.49182001
41BCAT_22108803_ChIP-Seq_LS180_Human1.48241356
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47867922
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.46565760
44DROSHA_22980978_ChIP-Seq_HELA_Human1.45939031
45* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43156861
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42143121
47* SOX2_21211035_ChIP-Seq_LN229_Gbm1.38788662
48AR_25329375_ChIP-Seq_VCAP_Human1.38379407
49NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36624093
50P53_22387025_ChIP-Seq_ESCs_Mouse1.34878336
51TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34472614
52TCF4_22108803_ChIP-Seq_LS180_Human1.32583267
53IGF1R_20145208_ChIP-Seq_DFB_Human1.31862350
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31192353
55KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30459264
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30091179
57CMYC_18555785_Chip-Seq_ESCs_Mouse1.27663649
58CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27036775
59E2F1_18555785_Chip-Seq_ESCs_Mouse1.26131859
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.25565635
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25323860
62RARB_27405468_Chip-Seq_BRAIN_Mouse1.24440420
63RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23382630
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.23371643
65ER_23166858_ChIP-Seq_MCF-7_Human1.22571154
66P300_18555785_Chip-Seq_ESCs_Mouse1.21607777
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21391217
68CBP_20019798_ChIP-Seq_JUKART_Human1.21391217
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20470087
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20449180
71SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20357995
72SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19379063
73ZNF274_21170338_ChIP-Seq_K562_Hela1.18313511
74STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16926543
75SOX2_18555785_Chip-Seq_ESCs_Mouse1.16761352
76AR_21572438_ChIP-Seq_LNCaP_Human1.15496726
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15329716
78* RUNX2_22187159_ChIP-Seq_PCA_Human1.15308603
79STAT3_18555785_Chip-Seq_ESCs_Mouse1.14366506
80SMAD4_21741376_ChIP-Seq_EPCs_Human1.14023715
81SOX9_26525672_Chip-Seq_HEART_Mouse1.13628966
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13316199
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13316199
84FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12176042
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.12055012
86SOX2_19829295_ChIP-Seq_ESCs_Human1.11319331
87NANOG_19829295_ChIP-Seq_ESCs_Human1.11319331
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09746739
89SMAD3_21741376_ChIP-Seq_ESCs_Human1.09366300
90CDX2_22108803_ChIP-Seq_LS180_Human1.09068470
91TAL1_26923725_Chip-Seq_HPCs_Mouse1.08995795
92KDM2B_26808549_Chip-Seq_REH_Human1.08517620
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08178220
94MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08167135
95EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07141897
96SMAD3_21741376_ChIP-Seq_HESCs_Human1.06512964
97SMAD4_21741376_ChIP-Seq_HESCs_Human1.05822079
98SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05690271
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04810276
100YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04512446

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia3.92211118
2MP0004859_abnormal_synaptic_plasticity3.75961656
3MP0003880_abnormal_central_pattern3.08631540
4MP0001968_abnormal_touch/_nociception2.91844310
5MP0002064_seizures2.91431133
6MP0002736_abnormal_nociception_after2.88245263
7MP0001486_abnormal_startle_reflex2.86122855
8MP0002272_abnormal_nervous_system2.81692621
9MP0003635_abnormal_synaptic_transmissio2.62043486
10MP0000920_abnormal_myelination2.61638540
11MP0004885_abnormal_endolymph2.59285434
12MP0009046_muscle_twitch2.57441137
13MP0009745_abnormal_behavioral_response2.54376723
14MP0002734_abnormal_mechanical_nocicepti2.46190552
15MP0003690_abnormal_glial_cell2.34405551
16MP0005423_abnormal_somatic_nervous2.17261040
17MP0001501_abnormal_sleep_pattern2.16287591
18MP0002063_abnormal_learning/memory/cond2.09390100
19MP0002735_abnormal_chemical_nociception2.04959230
20MP0008057_abnormal_DNA_replication2.00514809
21MP0009780_abnormal_chondrocyte_physiolo1.96824116
22MP0003787_abnormal_imprinting1.93063276
23MP0002572_abnormal_emotion/affect_behav1.89501033
24MP0001984_abnormal_olfaction1.89278859
25MP0008877_abnormal_DNA_methylation1.77082485
26MP0004147_increased_porphyrin_level1.76004688
27MP0001970_abnormal_pain_threshold1.73970898
28MP0001485_abnormal_pinna_reflex1.73525823
29MP0005646_abnormal_pituitary_gland1.69099238
30MP0005551_abnormal_eye_electrophysiolog1.62456711
31MP0001529_abnormal_vocalization1.57516301
32MP0010678_abnormal_skin_adnexa1.56334548
33MP0002733_abnormal_thermal_nociception1.53116589
34MP0008569_lethality_at_weaning1.52462325
35MP0002229_neurodegeneration1.45725936
36MP0002067_abnormal_sensory_capabilities1.43383508
37MP0003633_abnormal_nervous_system1.42778842
38MP0000383_abnormal_hair_follicle1.41602511
39MP0003632_abnormal_nervous_system1.38312776
40MP0002909_abnormal_adrenal_gland1.36436480
41MP0002557_abnormal_social/conspecific_i1.35561424
42MP0000778_abnormal_nervous_system1.35288425
43MP0003123_paternal_imprinting1.32534339
44MP0003631_nervous_system_phenotype1.26804003
45MP0005386_behavior/neurological_phenoty1.26598269
46MP0004924_abnormal_behavior1.26598269
47MP0004742_abnormal_vestibular_system1.25932553
48MP0003879_abnormal_hair_cell1.24969430
49MP0001440_abnormal_grooming_behavior1.22411713
50MP0003634_abnormal_glial_cell1.21802490
51MP0003195_calcinosis1.19797783
52MP0010234_abnormal_vibrissa_follicle1.16908252
53MP0002066_abnormal_motor_capabilities/c1.15821133
54MP0004043_abnormal_pH_regulation1.15751545
55MP0002882_abnormal_neuron_morphology1.11074980
56MP0003718_maternal_effect1.11026476
57MP0000427_abnormal_hair_cycle1.06938044
58MP0001963_abnormal_hearing_physiology1.05038999
59MP0000955_abnormal_spinal_cord1.03880370
60MP0006276_abnormal_autonomic_nervous1.03326080
61MP0008872_abnormal_physiological_respon1.02684400
62MP0001986_abnormal_taste_sensitivity1.02369669
63MP0005253_abnormal_eye_physiology1.01670934
64MP0005645_abnormal_hypothalamus_physiol1.00887208
65MP0004811_abnormal_neuron_physiology1.00773667
66MP0001177_atelectasis1.00729787
67MP0001905_abnormal_dopamine_level0.97689208
68MP0004142_abnormal_muscle_tone0.93610096
69MP0001188_hyperpigmentation0.93031343
70MP0001502_abnormal_circadian_rhythm0.92838532
71MP0000631_abnormal_neuroendocrine_gland0.90777155
72MP0010386_abnormal_urinary_bladder0.90017183
73MP0004215_abnormal_myocardial_fiber0.88455714
74MP0005379_endocrine/exocrine_gland_phen0.85926815
75MP0003283_abnormal_digestive_organ0.85203959
76MP0000569_abnormal_digit_pigmentation0.85169972
77MP0001346_abnormal_lacrimal_gland0.83334676
78MP0002876_abnormal_thyroid_physiology0.81928182
79MP0004019_abnormal_vitamin_homeostasis0.81741123
80MP0002152_abnormal_brain_morphology0.81426487
81MP0000579_abnormal_nail_morphology0.80658830
82MP0003136_yellow_coat_color0.78948937
83MP0003121_genomic_imprinting0.78640414
84MP0002254_reproductive_system_inflammat0.76995777
85MP0010352_gastrointestinal_tract_polyps0.75901507
86MP0003119_abnormal_digestive_system0.75250219
87MP0002752_abnormal_somatic_nervous0.73182543
88MP0000647_abnormal_sebaceous_gland0.72856395
89MP0002069_abnormal_eating/drinking_beha0.72165940
90MP0002090_abnormal_vision0.70100003
91MP0002184_abnormal_innervation0.70063682
92MP0002638_abnormal_pupillary_reflex0.68646108
93MP0003329_amyloid_beta_deposits0.68505252
94MP0001666_abnormal_nutrient_absorption0.68377490
95MP0010094_abnormal_chromosome_stability0.67796521
96MP0001756_abnormal_urination0.66928273
97MP0002938_white_spotting0.66764803
98MP0005174_abnormal_tail_pigmentation0.65009917
99MP0005360_urolithiasis0.64872175
100MP0005171_absent_coat_pigmentation0.64036628

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.61094761
2Degeneration of the lateral corticospinal tracts (HP:0002314)4.48826002
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.48826002
4Action tremor (HP:0002345)4.03679617
5Focal seizures (HP:0007359)3.83115231
6Abnormality of the corticospinal tract (HP:0002492)3.78859597
7Increased circulating renin level (HP:0000848)3.47174545
8Gaze-evoked nystagmus (HP:0000640)3.40259225
9Febrile seizures (HP:0002373)3.27482261
10Scanning speech (HP:0002168)3.20361037
11Myokymia (HP:0002411)3.03789206
12Epileptic encephalopathy (HP:0200134)3.03749231
13Metabolic alkalosis (HP:0200114)3.02254373
14Intention tremor (HP:0002080)2.93613354
15Generalized tonic-clonic seizures (HP:0002069)2.91080427
16Atonic seizures (HP:0010819)2.86527756
17Hyperventilation (HP:0002883)2.80552022
18Cerebral hypomyelination (HP:0006808)2.76816744
19Spastic gait (HP:0002064)2.73996433
20Ankle clonus (HP:0011448)2.66381133
21Dysmetria (HP:0001310)2.66137005
22Dialeptic seizures (HP:0011146)2.61988251
23Hypomagnesemia (HP:0002917)2.61646544
24Progressive cerebellar ataxia (HP:0002073)2.59299883
25Dysdiadochokinesis (HP:0002075)2.57061483
26Broad-based gait (HP:0002136)2.56936257
27Abnormality of the labia minora (HP:0012880)2.48890304
28Absent speech (HP:0001344)2.38649202
29Epileptiform EEG discharges (HP:0011182)2.38589526
30Hemiparesis (HP:0001269)2.38127372
31Confusion (HP:0001289)2.36060793
32Abnormality of renin-angiotensin system (HP:0000847)2.33433658
33Leukodystrophy (HP:0002415)2.28218532
34Absence seizures (HP:0002121)2.26968165
35Hypoglycemic seizures (HP:0002173)2.26353547
36Hyperaldosteronism (HP:0000859)2.24686583
37Abnormality of aspartate family amino acid metabolism (HP:0010899)2.24463147
38Abnormal eating behavior (HP:0100738)2.21932802
39Abnormality of vitamin B metabolism (HP:0004340)2.20054746
40Choreoathetosis (HP:0001266)2.17927418
41EEG with generalized epileptiform discharges (HP:0011198)2.17375072
42Abolished electroretinogram (ERG) (HP:0000550)2.15964171
43Hyperinsulinemic hypoglycemia (HP:0000825)2.12600062
44Abnormality of magnesium homeostasis (HP:0004921)2.10714650
45Urinary bladder sphincter dysfunction (HP:0002839)2.10267602
46Morphological abnormality of the inner ear (HP:0011390)2.08685058
47Hypsarrhythmia (HP:0002521)2.08117414
48Abnormality of the astrocytes (HP:0100707)2.04732068
49Astrocytoma (HP:0009592)2.04732068
50Lower limb muscle weakness (HP:0007340)2.03999752
51Alacrima (HP:0000522)2.01292044
52Impaired vibration sensation in the lower limbs (HP:0002166)2.01047861
53Congenital sensorineural hearing impairment (HP:0008527)2.00718763
54Spastic tetraparesis (HP:0001285)1.97587838
55Abnormal auditory evoked potentials (HP:0006958)1.97185395
56Volvulus (HP:0002580)1.92178499
57Urinary urgency (HP:0000012)1.91562145
58Neoplasm of the adrenal cortex (HP:0100641)1.90008900
59Abnormality of the vitamin B12 metabolism (HP:0004341)1.89810841
60Abnormality of cochlea (HP:0000375)1.88602181
61Hypokalemic alkalosis (HP:0001949)1.87919272
62Embryonal renal neoplasm (HP:0011794)1.87604311
63Neoplasm of the oral cavity (HP:0100649)1.87305959
64Protruding tongue (HP:0010808)1.86325922
65Hypoglycemic coma (HP:0001325)1.84977552
66Glioma (HP:0009733)1.84497702
67Diplopia (HP:0000651)1.83856492
68Abnormality of binocular vision (HP:0011514)1.83856492
69Postural instability (HP:0002172)1.82790436
70Impaired vibratory sensation (HP:0002495)1.81205912
71Abnormality of vitamin metabolism (HP:0100508)1.80175545
72Morphological abnormality of the pyramidal tract (HP:0002062)1.79239795
73CNS hypomyelination (HP:0003429)1.78705302
74Aqueductal stenosis (HP:0002410)1.77378119
75Clonus (HP:0002169)1.75019282
76Hyperactive renin-angiotensin system (HP:0000841)1.74624568
77Sensory axonal neuropathy (HP:0003390)1.71371053
78Anxiety (HP:0000739)1.71352490
79Status epilepticus (HP:0002133)1.71067187
80Megalencephaly (HP:0001355)1.70969998
81Poor eye contact (HP:0000817)1.70743755
82Paraplegia (HP:0010550)1.69872561
83Drooling (HP:0002307)1.69666927
84Polydipsia (HP:0001959)1.67762016
85Abnormal drinking behavior (HP:0030082)1.67762016
86Limb dystonia (HP:0002451)1.67737054
87Dysmetric saccades (HP:0000641)1.67735944
88Decreased lacrimation (HP:0000633)1.67145979
89Urethral obstruction (HP:0000796)1.65688468
90Biliary tract neoplasm (HP:0100574)1.65581797
91Colon cancer (HP:0003003)1.64314578
92Stridor (HP:0010307)1.64088619
93Neoplasm of the small intestine (HP:0100833)1.63461588
94Abnormality of serum amino acid levels (HP:0003112)1.63160597
95Spastic paraplegia (HP:0001258)1.62069635
96Peripheral hypomyelination (HP:0007182)1.61884041
97Symptomatic seizures (HP:0011145)1.61601298
98Bell-shaped thorax (HP:0001591)1.61206142
99Bony spicule pigmentary retinopathy (HP:0007737)1.60108627
100Truncal ataxia (HP:0002078)1.59914635

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.57435231
2CASK3.08254399
3NTRK32.85112383
4TNIK2.84279804
5UHMK12.66366036
6OXSR12.65995379
7STK392.48299796
8EPHA42.46912882
9FGFR22.46025703
10ACVR1B2.26090704
11DAPK21.99042693
12MKNK21.88613359
13PBK1.88116919
14MST41.82866968
15BMPR1B1.73067449
16MARK11.65189823
17PLK21.63110835
18TAF11.55487204
19WNK31.55123943
20MST1R1.50348883
21MET1.43611042
22MAP3K41.40961187
23CAMK2B1.38158750
24STK38L1.31810319
25ERBB31.26971356
26MINK11.26423769
27PLK31.26183255
28TRIM281.23007723
29PAK61.20592853
30PKN11.20321175
31NTRK21.19696242
32MAP3K91.16114446
33TTK1.14398114
34MKNK11.13485423
35INSRR1.09541328
36PINK11.06954289
37CAMK2D1.06387473
38PHKG21.05127857
39PHKG11.05127857
40NEK11.04333595
41MAP4K21.02132051
42DAPK11.00946082
43NEK61.00767745
44PRKCG1.00643664
45TSSK60.98206540
46CSNK1G10.96663301
47MAPK130.93598236
48CAMK2A0.93577560
49PRKCE0.92225399
50ZAK0.92175794
51PAK30.91111691
52CAMK2G0.90310293
53GRK10.87319912
54SGK20.86716729
55SGK2230.86691487
56SGK4940.86691487
57CDK50.84545157
58BUB10.81250685
59CSNK1G20.81128673
60ALK0.79681866
61BRSK10.79394536
62LMTK20.76171406
63MAPKAPK50.71554331
64PLK40.70068305
65BRSK20.69591781
66ROCK20.68270927
67WNK40.67209739
68YES10.66581895
69PNCK0.65344444
70PRKD30.64010428
71NUAK10.62505758
72BMPR20.61199191
73PLK10.59608769
74CSNK1A1L0.59453076
75NLK0.59217973
76SGK10.59088785
77CDC70.58596351
78MAP3K20.55060316
79CSNK1G30.53970691
80BCR0.53221916
81STK110.52279301
82CAMK10.50209278
83STK30.49779731
84CSNK1A10.49731634
85MAPK100.48369628
86SGK30.47378763
87CSNK1D0.46794396
88FGFR10.46231286
89DYRK1A0.45725159
90CAMK1G0.44905103
91RPS6KA30.44022301
92CSNK1E0.43737329
93PRKG10.43325480
94FER0.41985342
95NTRK10.40722506
96PRKCA0.40095333
97CDK180.39471725
98PRKG20.38475460
99PTK2B0.38466269
100ADRBK20.38310853

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.33832895
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.63799063
3Histidine metabolism_Homo sapiens_hsa003402.48013090
4Insulin secretion_Homo sapiens_hsa049112.29745629
5Vitamin B6 metabolism_Homo sapiens_hsa007502.21765006
6Glutamatergic synapse_Homo sapiens_hsa047242.14850643
7Synaptic vesicle cycle_Homo sapiens_hsa047212.12037968
8Circadian entrainment_Homo sapiens_hsa047132.04913019
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.95515690
10GABAergic synapse_Homo sapiens_hsa047271.90845723
11Amphetamine addiction_Homo sapiens_hsa050311.86308159
12beta-Alanine metabolism_Homo sapiens_hsa004101.76642621
13Morphine addiction_Homo sapiens_hsa050321.72233940
14Long-term potentiation_Homo sapiens_hsa047201.71046267
15Gastric acid secretion_Homo sapiens_hsa049711.65710737
16Nitrogen metabolism_Homo sapiens_hsa009101.57702880
17Arginine and proline metabolism_Homo sapiens_hsa003301.56305640
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.55114437
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.53619482
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.52300636
21Salivary secretion_Homo sapiens_hsa049701.52197202
22Dopaminergic synapse_Homo sapiens_hsa047281.49614881
23Renin secretion_Homo sapiens_hsa049241.48717727
24Taste transduction_Homo sapiens_hsa047421.44700019
25Phototransduction_Homo sapiens_hsa047441.41266194
26Pancreatic secretion_Homo sapiens_hsa049721.40388328
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.38621721
28Olfactory transduction_Homo sapiens_hsa047401.37230433
29Cocaine addiction_Homo sapiens_hsa050301.34968695
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.34605554
31* Ether lipid metabolism_Homo sapiens_hsa005651.32381356
32Mineral absorption_Homo sapiens_hsa049781.32155730
33Long-term depression_Homo sapiens_hsa047301.26982945
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.26249400
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25975623
36Sulfur metabolism_Homo sapiens_hsa009201.24116626
37Propanoate metabolism_Homo sapiens_hsa006401.20966616
38Bile secretion_Homo sapiens_hsa049761.19482404
39Serotonergic synapse_Homo sapiens_hsa047261.19079042
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15477870
41Butanoate metabolism_Homo sapiens_hsa006501.13510125
42Non-homologous end-joining_Homo sapiens_hsa034501.10982362
43Oocyte meiosis_Homo sapiens_hsa041141.00776553
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00205395
45Calcium signaling pathway_Homo sapiens_hsa040200.95674755
46cAMP signaling pathway_Homo sapiens_hsa040240.94555669
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94523270
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90501694
49Collecting duct acid secretion_Homo sapiens_hsa049660.90150695
50Thyroid hormone synthesis_Homo sapiens_hsa049180.88799045
51Arginine biosynthesis_Homo sapiens_hsa002200.88667171
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88077753
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87987938
54Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87805131
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.84750265
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83843819
57Tryptophan metabolism_Homo sapiens_hsa003800.81668205
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.80254548
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.76868003
60Folate biosynthesis_Homo sapiens_hsa007900.76323921
61Tight junction_Homo sapiens_hsa045300.75165563
62Cholinergic synapse_Homo sapiens_hsa047250.74869902
63Vitamin digestion and absorption_Homo sapiens_hsa049770.73743185
64Fat digestion and absorption_Homo sapiens_hsa049750.73333174
65Glycerolipid metabolism_Homo sapiens_hsa005610.72641481
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72337117
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71877204
68Retinol metabolism_Homo sapiens_hsa008300.71381294
69Fatty acid metabolism_Homo sapiens_hsa012120.71250456
70Linoleic acid metabolism_Homo sapiens_hsa005910.68180445
71ABC transporters_Homo sapiens_hsa020100.67041421
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65702739
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.64774182
74Inositol phosphate metabolism_Homo sapiens_hsa005620.62040443
75Homologous recombination_Homo sapiens_hsa034400.61114994
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58908196
77Circadian rhythm_Homo sapiens_hsa047100.58087962
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58080569
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57232543
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56837151
81Lysine degradation_Homo sapiens_hsa003100.54793058
82Protein export_Homo sapiens_hsa030600.54232001
83Protein digestion and absorption_Homo sapiens_hsa049740.54008303
84Oxytocin signaling pathway_Homo sapiens_hsa049210.52749446
85Fatty acid biosynthesis_Homo sapiens_hsa000610.51503032
86Gap junction_Homo sapiens_hsa045400.51227328
87Fatty acid elongation_Homo sapiens_hsa000620.50373109
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.49765234
89* Sphingolipid metabolism_Homo sapiens_hsa006000.49340209
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.48965795
91Mismatch repair_Homo sapiens_hsa034300.45578008
92Basal transcription factors_Homo sapiens_hsa030220.44430699
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43636404
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41639351
95Estrogen signaling pathway_Homo sapiens_hsa049150.41480497
96Peroxisome_Homo sapiens_hsa041460.40772277
97Starch and sucrose metabolism_Homo sapiens_hsa005000.40551070
98Vibrio cholerae infection_Homo sapiens_hsa051100.39997608
99Caffeine metabolism_Homo sapiens_hsa002320.39054020
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38901533

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