UGT2A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1xenobiotic catabolic process (GO:0042178)9.66838631
2response to nitrosative stress (GO:0051409)8.61955188
3negative regulation of fatty acid transport (GO:2000192)8.40452954
4one-carbon compound transport (GO:0019755)7.57332878
5inner ear receptor cell differentiation (GO:0060113)6.80631455
6regulation of chemokine secretion (GO:0090196)6.12998069
7regulation of phospholipase A2 activity (GO:0032429)6.12505553
8mechanoreceptor differentiation (GO:0042490)6.11028801
9energy homeostasis (GO:0097009)6.10891514
10phenylpropanoid metabolic process (GO:0009698)6.09059537
11regulation of cholesterol biosynthetic process (GO:0045540)5.97044669
12regulation of skeletal muscle contraction (GO:0014819)5.74158907
13Notch signaling involved in heart development (GO:0061314)5.70547479
14negative regulation of lipase activity (GO:0060192)5.27763499
15L-ascorbic acid metabolic process (GO:0019852)5.27384474
16replicative senescence (GO:0090399)5.03660378
17auditory receptor cell differentiation (GO:0042491)4.93897557
18glutathione derivative metabolic process (GO:1901685)4.90054640
19glutathione derivative biosynthetic process (GO:1901687)4.90054640
20flavonoid metabolic process (GO:0009812)4.81363366
21glutathione metabolic process (GO:0006749)4.43515621
22relaxation of cardiac muscle (GO:0055119)4.40260130
23regulation of secondary heart field cardioblast proliferation (GO:0003266)4.38722372
24regulation of cardioblast proliferation (GO:0003264)4.38722372
25regulation of superoxide anion generation (GO:0032928)4.36702574
26positive regulation of chemokine secretion (GO:0090197)4.27064679
27cell differentiation involved in metanephros development (GO:0072202)4.21482418
28positive regulation of icosanoid secretion (GO:0032305)4.17233912
29benzene-containing compound metabolic process (GO:0042537)4.15922028
30nucleotide transmembrane transport (GO:1901679)4.15193107
31calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.11138384
32positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.11049109
33hormone catabolic process (GO:0042447)4.09914762
34aorta morphogenesis (GO:0035909)4.02695696
35amyloid precursor protein catabolic process (GO:0042987)3.96334613
36renal absorption (GO:0070293)3.93383468
37relaxation of muscle (GO:0090075)3.91654719
38cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.88760208
39pharyngeal system development (GO:0060037)3.70311040
40muscle cell migration (GO:0014812)3.68495064
41positive regulation of steroid biosynthetic process (GO:0010893)3.66167691
42purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.58703174
433-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.58703174
44glomerulus development (GO:0032835)3.57281806
45sulfur amino acid catabolic process (GO:0000098)3.55334224
46sensory perception of smell (GO:0007608)3.53773984
47heterotypic cell-cell adhesion (GO:0034113)3.51435598
48regulation of cholesterol metabolic process (GO:0090181)3.49242510
49negative regulation of organic acid transport (GO:0032891)3.47707699
50heart valve formation (GO:0003188)3.44692836
51polyol transport (GO:0015791)3.41318394
52positive regulation of fatty acid transport (GO:2000193)3.37503178
53hydrogen peroxide biosynthetic process (GO:0050665)3.33919356
54negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.33211099
55negative regulation of chondrocyte differentiation (GO:0032331)3.32534320
56positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.32005016
57cellular response to oxygen radical (GO:0071450)3.28340650
58removal of superoxide radicals (GO:0019430)3.28340650
59cellular response to superoxide (GO:0071451)3.28340650
60outer ear morphogenesis (GO:0042473)3.25217023
61L-serine transport (GO:0015825)3.24133368
62outflow tract septum morphogenesis (GO:0003148)3.20820037
63relaxation of smooth muscle (GO:0044557)3.17504968
64positive regulation of fatty acid beta-oxidation (GO:0032000)3.14764622
65regulation of icosanoid secretion (GO:0032303)3.09794972
66galactose metabolic process (GO:0006012)3.04381958
67generation of neurons (GO:0048699)3.04375077
68bundle of His cell to Purkinje myocyte communication (GO:0086069)3.02469490
69sulfation (GO:0051923)3.01712974
70neurofilament cytoskeleton organization (GO:0060052)3.00011627
71neuronal ion channel clustering (GO:0045161)2.99221583
72regulation of superoxide metabolic process (GO:0090322)2.98569894
73iron ion import (GO:0097286)2.96464621
74reactive oxygen species biosynthetic process (GO:1903409)2.93830972
75positive regulation of cholesterol efflux (GO:0010875)2.91653496
76proline transport (GO:0015824)2.91159017
77artery smooth muscle contraction (GO:0014824)2.90485519
78heart valve morphogenesis (GO:0003179)2.89517319
79bone remodeling (GO:0046849)2.82129865
80positive regulation of actin filament depolymerization (GO:0030836)2.80190864
81carnitine metabolic process (GO:0009437)2.78312833
82positive regulation of hormone biosynthetic process (GO:0046886)2.77161692
83positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.76280467
84endocardial cushion morphogenesis (GO:0003203)2.76196625
85serine transport (GO:0032329)2.71851584
86positive regulation of signal transduction by p53 class mediator (GO:1901798)2.71349710
87positive regulation of cellular response to oxidative stress (GO:1900409)2.70207633
88positive regulation of response to oxidative stress (GO:1902884)2.70207633
89hair cell differentiation (GO:0035315)2.66190860
90pyrimidine-containing compound transmembrane transport (GO:0072531)2.63963572
91xenobiotic metabolic process (GO:0006805)2.63445243
92retina homeostasis (GO:0001895)2.63009844
93positive regulation of sterol transport (GO:0032373)2.62649152
94positive regulation of cholesterol transport (GO:0032376)2.62649152
95regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.61955199
96response to superoxide (GO:0000303)2.60924220
97prostanoid metabolic process (GO:0006692)2.60593104
98glucuronate metabolic process (GO:0019585)13.4128396
99uronic acid metabolic process (GO:0006063)13.4128396
100cellular glucuronidation (GO:0052695)12.8957401

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.37592254
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.04540316
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.39232340
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.18576290
5FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.67806733
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.67662635
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.65829085
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.43845283
9CDX2_20551321_ChIP-Seq_CACO-2_Human2.41077337
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.34847502
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.21294829
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.19114061
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.15237318
14CLOCK_20551151_ChIP-Seq_293T_Human2.11986633
15AHR_22903824_ChIP-Seq_MCF-7_Human2.08433765
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05275232
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82595881
18DROSHA_22980978_ChIP-Seq_HELA_Human1.75437030
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.74348988
20TP53_18474530_ChIP-ChIP_U2OS_Human1.71104459
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.69775774
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.69391390
23NRF2_20460467_ChIP-Seq_MEFs_Mouse1.68596500
24NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.68596500
25LXR_22158963_ChIP-Seq_LIVER_Mouse1.64337247
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.59914356
27ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.53052296
28CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52137099
29ZNF263_19887448_ChIP-Seq_K562_Human1.51917747
30RXR_22158963_ChIP-Seq_LIVER_Mouse1.50325093
31CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.50159030
32ARNT_22903824_ChIP-Seq_MCF-7_Human1.47613096
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.46390492
34TAF15_26573619_Chip-Seq_HEK293_Human1.44022018
35SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.43171567
36SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.43171567
37AR_21572438_ChIP-Seq_LNCaP_Human1.42997360
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.39733707
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38135162
40SOX2_20726797_ChIP-Seq_SW620_Human1.33967883
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29384739
42ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26794906
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.25210475
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23331554
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22739619
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22739619
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22355467
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21959042
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21889735
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20737526
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.19781976
52SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18626917
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17300528
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17141951
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.15780213
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15596045
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14565539
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.09558951
59TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.09072455
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09002761
61FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08941679
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08656469
63KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08656469
64KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08656469
65Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08417605
66STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05859358
67* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04817086
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03162431
69NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02746730
70EED_16625203_ChIP-ChIP_MESCs_Mouse0.99766412
71RING1B_27294783_Chip-Seq_NPCs_Mouse0.98689689
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98257796
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97875734
74TCF4_18268006_ChIP-ChIP_LS174T_Human0.97534913
75TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97034123
76GATA3_24758297_ChIP-Seq_MCF-7_Human0.94383172
77GBX2_23144817_ChIP-Seq_PC3_Human0.92499883
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91412066
79TP53_20018659_ChIP-ChIP_R1E_Mouse0.91133817
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90254351
81SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.89555479
82TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89399013
83RING1B_27294783_Chip-Seq_ESCs_Mouse0.89264620
84CJUN_26792858_Chip-Seq_BT549_Human0.88652407
85WT1_19549856_ChIP-ChIP_CCG9911_Human0.88098476
86MTF2_20144788_ChIP-Seq_MESCs_Mouse0.87906485
87RNF2_27304074_Chip-Seq_ESCs_Mouse0.87798678
88P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86474392
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86434407
90HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85701360
91* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85401014
92KLF5_25053715_ChIP-Seq_YYC3_Human0.84777298
93RUNX_20019798_ChIP-Seq_JUKART_Human0.83767604
94JARID2_20075857_ChIP-Seq_MESCs_Mouse0.82512089
95SMAD_19615063_ChIP-ChIP_OVARY_Human0.81999188
96TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.81442919
97SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.80652118
98PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80234504
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80229256
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.80034105

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005394_taste/olfaction_phenotype8.09017802
2MP0005499_abnormal_olfactory_system8.09017802
3MP0008789_abnormal_olfactory_epithelium6.87690743
4MP0008875_abnormal_xenobiotic_pharmacok6.15868405
5MP0001984_abnormal_olfaction5.84106849
6MP0010030_abnormal_orbit_morphology3.43170252
7MP0003878_abnormal_ear_physiology3.25906698
8MP0005377_hearing/vestibular/ear_phenot3.25906698
9MP0002877_abnormal_melanocyte_morpholog2.88965781
10MP0003186_abnormal_redox_activity2.53373549
11MP0002254_reproductive_system_inflammat2.52152390
12MP0002233_abnormal_nose_morphology2.07155731
13MP0009053_abnormal_anal_canal2.02013028
14MP0001346_abnormal_lacrimal_gland1.72292539
15MP0000762_abnormal_tongue_morphology1.69543375
16MP0000678_abnormal_parathyroid_gland1.66210260
17MP0005365_abnormal_bile_salt1.62109225
18MP0000613_abnormal_salivary_gland1.60365103
19MP0003279_aneurysm1.58147518
20MP0005085_abnormal_gallbladder_physiolo1.49105553
21MP0001919_abnormal_reproductive_system1.31386712
22MP0003941_abnormal_skin_development1.28603373
23MP0006292_abnormal_olfactory_placode1.24986142
24MP0009250_abnormal_appendicular_skeleto1.23946097
25MP0002132_abnormal_respiratory_system1.23892280
26MP0002098_abnormal_vibrissa_morphology1.23513121
27MP0000049_abnormal_middle_ear1.16774124
28MP0004264_abnormal_extraembryonic_tissu1.13516919
29MP0002295_abnormal_pulmonary_circulatio1.13114519
30MP0000467_abnormal_esophagus_morphology1.08899075
31MP0000534_abnormal_ureter_morphology1.07911103
32MP0002009_preneoplasia1.07887949
33MP0003828_pulmonary_edema1.03386813
34MP0010368_abnormal_lymphatic_system1.02449652
35MP0002249_abnormal_larynx_morphology1.02140369
36MP0000566_synostosis1.00948508
37MP0001958_emphysema0.93688916
38MP0005197_abnormal_uvea_morphology0.91886331
39MP0003786_premature_aging0.91610783
40MP0002133_abnormal_respiratory_system0.90775973
41MP0005388_respiratory_system_phenotype0.90775973
42MP0005408_hypopigmentation0.86939965
43MP0009379_abnormal_foot_pigmentation0.85782177
44MP0005248_abnormal_Harderian_gland0.82325120
45MP0003937_abnormal_limbs/digits/tail_de0.81016988
46MP0002277_abnormal_respiratory_mucosa0.79411021
47MP0005389_reproductive_system_phenotype0.78629170
48MP0010329_abnormal_lipoprotein_level0.77999731
49MP0004043_abnormal_pH_regulation0.77512818
50MP0008872_abnormal_physiological_respon0.74709597
51MP0005266_abnormal_metabolism0.74190277
52MP0002090_abnormal_vision0.72988843
53MP0003566_abnormal_cell_adhesion0.72788052
54MP0004147_increased_porphyrin_level0.72767670
55MP0005647_abnormal_sex_gland0.72290757
56MP0001177_atelectasis0.71789418
57MP0001849_ear_inflammation0.71356292
58MP0002653_abnormal_ependyma_morphology0.70213494
59MP0003806_abnormal_nucleotide_metabolis0.66374622
60MP0003942_abnormal_urinary_system0.65265018
61MP0006072_abnormal_retinal_apoptosis0.65069760
62MP0002177_abnormal_outer_ear0.61559204
63MP0001851_eye_inflammation0.60553457
64MP0003755_abnormal_palate_morphology0.60454403
65MP0002928_abnormal_bile_duct0.58816067
66MP0001501_abnormal_sleep_pattern0.57535973
67MP0003075_altered_response_to0.57333368
68MP0001270_distended_abdomen0.56004631
69MP0002160_abnormal_reproductive_system0.55866532
70MP0000767_abnormal_smooth_muscle0.55794107
71MP0000372_irregular_coat_pigmentation0.54738043
72MP0002938_white_spotting0.54704966
73MP0002127_abnormal_cardiovascular_syste0.54179965
74MP0004134_abnormal_chest_morphology0.53204381
75MP0000579_abnormal_nail_morphology0.52942740
76MP0002168_other_aberrant_phenotype0.51569571
77MP0000383_abnormal_hair_follicle0.51121982
78MP0003453_abnormal_keratinocyte_physiol0.48782208
79MP0004782_abnormal_surfactant_physiolog0.47528679
80MP0002405_respiratory_system_inflammati0.47341574
81MP0002092_abnormal_eye_morphology0.47080130
82MP0005023_abnormal_wound_healing0.46347009
83MP0001485_abnormal_pinna_reflex0.45687804
84MP0003938_abnormal_ear_development0.44304690
85MP0000026_abnormal_inner_ear0.43317722
86MP0003385_abnormal_body_wall0.42928957
87MP0002751_abnormal_autonomic_nervous0.41941980
88MP0003690_abnormal_glial_cell0.41924515
89MP0005646_abnormal_pituitary_gland0.41599435
90MP0000465_gastrointestinal_hemorrhage0.41205236
91MP0001963_abnormal_hearing_physiology0.40654941
92MP0003890_abnormal_embryonic-extraembry0.40556949
93MP0004233_abnormal_muscle_weight0.39664119
94MP0002060_abnormal_skin_morphology0.37450109
95MP0005319_abnormal_enzyme/_coenzyme0.37033209
96MP0009765_abnormal_xenobiotic_induced0.36977295
97MP0005171_absent_coat_pigmentation0.35747798
98MP0005508_abnormal_skeleton_morphology0.34654854
99MP0001905_abnormal_dopamine_level0.33635815
100MP0003252_abnormal_bile_duct0.33374945

Predicted human phenotypes

RankGene SetZ-score
1Potter facies (HP:0002009)8.23215429
2Facial shape deformation (HP:0011334)8.23215429
3Lip pit (HP:0100267)6.39308495
4Renal tubular acidosis (HP:0001947)5.11867472
5Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)4.74602425
6Redundant skin (HP:0001582)4.65619845
7Periauricular skin pits (HP:0100277)4.37995598
8Preauricular pit (HP:0004467)4.37995598
9Abnormal hemoglobin (HP:0011902)4.37572590
10Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)4.30531261
11Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.90073408
12Abnormality of the phalanges of the 2nd finger (HP:0009541)3.85510737
13Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.77972096
14Degeneration of the lateral corticospinal tracts (HP:0002314)3.77972096
15Popliteal pterygium (HP:0009756)3.61420974
16Fibular aplasia (HP:0002990)3.61094077
17Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.60565450
18Humeroradial synostosis (HP:0003041)3.50790219
19Synostosis involving the elbow (HP:0003938)3.50790219
20Bifid scrotum (HP:0000048)3.45575185
21Stomach cancer (HP:0012126)3.45561496
22Bronchomalacia (HP:0002780)3.42235512
23Papillary thyroid carcinoma (HP:0002895)3.40742632
24Aplasia involving bones of the extremities (HP:0009825)3.34434353
25Aplasia involving bones of the upper limbs (HP:0009823)3.34434353
26Aplasia of the phalanges of the hand (HP:0009802)3.34434353
27Abnormality of the distal phalanges of the toes (HP:0010182)3.31223048
28Abnormality of the phalanges of the 5th finger (HP:0004213)3.30884848
29Abnormality of the middle phalanges of the toes (HP:0010183)3.23450152
30Skin pits (HP:0100276)3.22055847
31Stenosis of the external auditory canal (HP:0000402)3.21186938
32Cupped ear (HP:0000378)3.19558311
33Pulmonary artery stenosis (HP:0004415)3.19244162
34Renal tubular dysfunction (HP:0000124)3.11483545
35Glucose intolerance (HP:0000833)2.95364359
36Chorioretinal atrophy (HP:0000533)2.90658054
37Down-sloping shoulders (HP:0200021)2.90618346
38Renal dysplasia (HP:0000110)2.85944119
39Right ventricular cardiomyopathy (HP:0011663)2.82076501
40Abnormality of the proximal phalanges of the hand (HP:0009834)2.81220492
41Labial hypoplasia (HP:0000066)2.78556845
42Renal cortical cysts (HP:0000803)2.78019124
43Hypoplasia of the ulna (HP:0003022)2.74506519
44Abnormality of the corticospinal tract (HP:0002492)2.73998734
45Abnormal tarsal ossification (HP:0008369)2.71397125
46Hypoplasia of the uterus (HP:0000013)2.66906846
47Vertebral arch anomaly (HP:0008438)2.64693339
48Vaginal fistula (HP:0004320)2.60129447
49Aplasia/Hypoplasia of the scapulae (HP:0006713)2.59651203
50Hypoplastic scapulae (HP:0000882)2.59651203
51Ulnar bowing (HP:0003031)2.57961935
52Tarsal synostosis (HP:0008368)2.56759908
53Hydroureter (HP:0000072)2.49847029
54Hemivertebrae (HP:0002937)2.49801837
55Hypoplastic female external genitalia (HP:0012815)2.48455212
56Split foot (HP:0001839)2.47050885
57Synostosis involving bones of the lower limbs (HP:0009138)2.38839941
58Synostosis involving bones of the feet (HP:0009140)2.38839941
59Abnormality of the renal collecting system (HP:0004742)2.37481005
60Urethral obstruction (HP:0000796)2.37327957
61Morphological abnormality of the middle ear (HP:0008609)2.34020112
62Abnormality of the 2nd finger (HP:0004100)2.32828838
63Hypoplastic labia majora (HP:0000059)2.32373514
64Progressive sensorineural hearing impairment (HP:0000408)2.29769529
65Short hallux (HP:0010109)2.26434888
66Absent eyebrow (HP:0002223)2.23665458
67Degeneration of anterior horn cells (HP:0002398)2.22684767
68Abnormality of the anterior horn cell (HP:0006802)2.22684767
69Prolonged neonatal jaundice (HP:0006579)2.21213379
70Abnormality of cochlea (HP:0000375)2.20598726
71Short middle phalanx of the 5th finger (HP:0004220)2.19131973
72Thyroid carcinoma (HP:0002890)2.16943493
73Pulmonary hypoplasia (HP:0002089)2.16473322
74Submucous cleft hard palate (HP:0000176)2.15708833
75Hypercholesterolemia (HP:0003124)2.15201278
76Bowed forearm bones (HP:0003956)2.13294419
77Bowing of the arm (HP:0006488)2.13294419
78Anterior segment dysgenesis (HP:0007700)2.13195237
79Aplasia/Hypoplasia of the ulna (HP:0006495)2.12211079
80Adactyly (HP:0009776)2.11844893
81Abnormality of the labia (HP:0000058)2.09189856
82Onycholysis (HP:0001806)2.06419419
83Abnormality of the labia majora (HP:0012881)2.06247284
84Aplasia/hypoplasia of the uterus (HP:0008684)2.05795237
85Pseudobulbar signs (HP:0002200)2.05160033
86Absent eyelashes (HP:0000561)2.04369972
87Dysphonia (HP:0001618)2.03925495
88Aplasia/Hypoplasia of the hallux (HP:0008362)2.01182556
89Non-midline cleft lip (HP:0100335)2.00834463
90Abnormal glucose tolerance (HP:0001952)1.99676094
91Carpal synostosis (HP:0009702)1.98713006
92Sleep apnea (HP:0010535)1.98648209
93Steatorrhea (HP:0002570)1.97011994
94Syncope (HP:0001279)1.95614672
95Distal lower limb muscle weakness (HP:0009053)1.93168212
96Palpitations (HP:0001962)1.92425663
97Fair hair (HP:0002286)1.92357586
98Tubulointerstitial nephritis (HP:0001970)1.89774265
99Femoral bowing (HP:0002980)1.89112891
100Nuclear cataract (HP:0100018)1.88090009

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K24.33198674
2ZAK4.08842261
3MST43.86867543
4MAP3K33.77855018
5ERBB33.63407437
6ADRBK23.41581762
7BMPR22.99510742
8RPS6KB22.84383596
9MAPK152.76660983
10MAP2K22.13853231
11PAK31.98839839
12MAP2K11.95312715
13PBK1.90552948
14EPHA21.84744963
15MAP3K141.72673751
16BCKDK1.70110341
17CSNK1A1L1.66373112
18INSRR1.53444872
19NME11.51279468
20HIPK21.45354701
21TNIK1.43350201
22EPHB21.39576578
23MAP3K131.33496342
24TESK11.31392814
25CAMKK21.28344659
26CAMK1D1.28142050
27BMPR1B1.27777370
28MAP2K31.21172961
29EPHB11.05260750
30STK390.99345558
31PRPF4B0.99023890
32MAP3K70.98240367
33PRKD30.96580437
34NUAK10.94576163
35MAPKAPK50.92895109
36MAP3K60.91883441
37NLK0.89467857
38RIPK40.87705272
39NEK60.87337310
40STK40.86597300
41CAMK1G0.86041970
42TRPM70.85008928
43FER0.83933496
44CSNK1G30.83475946
45TSSK60.83321537
46CAMKK10.81803619
47CAMK40.81491162
48SGK20.80599966
49CHUK0.80509873
50SIK10.77175714
51PDGFRB0.74643820
52TRIB30.73575091
53PRKCE0.73112391
54SGK4940.69125337
55SGK2230.69125337
56CASK0.68312233
57IKBKB0.65854994
58ERBB40.65172356
59CAMK10.63910572
60MAPKAPK30.61526807
61RIPK10.61493801
62STK100.61221058
63MAP2K60.60851745
64ERBB20.60820066
65EPHA30.60505878
66CSNK1G20.60218362
67CDK60.60214758
68CSNK1G10.58632380
69TNK20.58632241
70VRK10.55974429
71PRKCI0.53175400
72PDK20.50698279
73PHKG10.50333504
74PHKG20.50333504
75TXK0.48877140
76LATS20.47754902
77MAPK70.46655272
78ROCK20.45976185
79SGK30.44413085
80MKNK20.43872311
81LIMK10.41696832
82PRKD10.41211687
83OXSR10.39056657
84CAMK2D0.38729189
85CSNK1A10.38392738
86TAOK20.37916035
87STK38L0.37788552
88PINK10.37008597
89MST1R0.35384024
90CAMK2B0.33734179
91MAP3K110.32931042
92TEC0.28698509
93WNK10.27447991
94GRK10.26988914
95MARK20.24914234
96ROCK10.23144113
97IKBKE0.23081134
98DYRK1A0.21815469
99MAP3K10.20998605
100LMTK20.19064614

Predicted pathways (KEGG)

RankGene SetZ-score
1* Pentose and glucuronate interconversions_Homo sapiens_hsa000406.16239768
2* Ascorbate and aldarate metabolism_Homo sapiens_hsa000535.53199041
3* Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.83245192
4* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.79277887
5* Chemical carcinogenesis_Homo sapiens_hsa052044.25901936
6Sulfur metabolism_Homo sapiens_hsa009203.91493718
7* Steroid hormone biosynthesis_Homo sapiens_hsa001403.25647614
8Glutathione metabolism_Homo sapiens_hsa004802.85678431
9Caffeine metabolism_Homo sapiens_hsa002322.47392049
10Butanoate metabolism_Homo sapiens_hsa006502.47109826
11* Drug metabolism - other enzymes_Homo sapiens_hsa009832.46735733
12* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.41973305
13* Starch and sucrose metabolism_Homo sapiens_hsa005002.41392513
14Sulfur relay system_Homo sapiens_hsa041222.40377332
15* Retinol metabolism_Homo sapiens_hsa008302.15043660
16Galactose metabolism_Homo sapiens_hsa000521.66535836
17ABC transporters_Homo sapiens_hsa020101.42302583
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31655018
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17308946
20Mineral absorption_Homo sapiens_hsa049781.06754468
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92120576
22Collecting duct acid secretion_Homo sapiens_hsa049660.90494049
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89061138
24Primary bile acid biosynthesis_Homo sapiens_hsa001200.85924096
25Peroxisome_Homo sapiens_hsa041460.83396344
26Cyanoamino acid metabolism_Homo sapiens_hsa004600.77408965
27Prion diseases_Homo sapiens_hsa050200.73453540
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72219637
29beta-Alanine metabolism_Homo sapiens_hsa004100.67106927
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65062424
31Tight junction_Homo sapiens_hsa045300.63336473
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59029856
33Cysteine and methionine metabolism_Homo sapiens_hsa002700.57243292
34Circadian rhythm_Homo sapiens_hsa047100.57026478
35Axon guidance_Homo sapiens_hsa043600.55620978
36Gastric acid secretion_Homo sapiens_hsa049710.54694325
37Melanoma_Homo sapiens_hsa052180.54193547
38Rheumatoid arthritis_Homo sapiens_hsa053230.52869559
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49785279
40Notch signaling pathway_Homo sapiens_hsa043300.49572519
41Leukocyte transendothelial migration_Homo sapiens_hsa046700.48508052
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48172974
43Phagosome_Homo sapiens_hsa041450.46316322
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45785597
45Olfactory transduction_Homo sapiens_hsa047400.38941443
46Bile secretion_Homo sapiens_hsa049760.38192813
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38025717
48Vibrio cholerae infection_Homo sapiens_hsa051100.37766308
49TNF signaling pathway_Homo sapiens_hsa046680.37717631
50Adherens junction_Homo sapiens_hsa045200.36497487
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35828024
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34023419
53Synaptic vesicle cycle_Homo sapiens_hsa047210.33961989
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32881438
55Cocaine addiction_Homo sapiens_hsa050300.30411262
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29153733
57Renin secretion_Homo sapiens_hsa049240.28773785
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28629716
59Amphetamine addiction_Homo sapiens_hsa050310.27451455
60Phenylalanine metabolism_Homo sapiens_hsa003600.26669688
61Steroid biosynthesis_Homo sapiens_hsa001000.24696993
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22709286
63Prostate cancer_Homo sapiens_hsa052150.22313878
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.21843402
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.20849419
66Fatty acid degradation_Homo sapiens_hsa000710.19978948
67African trypanosomiasis_Homo sapiens_hsa051430.19646970
68Type II diabetes mellitus_Homo sapiens_hsa049300.19163569
69Fructose and mannose metabolism_Homo sapiens_hsa000510.18946210
70Hepatitis C_Homo sapiens_hsa051600.18711679
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.18684486
72Tyrosine metabolism_Homo sapiens_hsa003500.18618216
73Hippo signaling pathway_Homo sapiens_hsa043900.17936610
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.17500036
75ECM-receptor interaction_Homo sapiens_hsa045120.17392241
76MAPK signaling pathway_Homo sapiens_hsa040100.15287521
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.13984134
78One carbon pool by folate_Homo sapiens_hsa006700.13337477
79Propanoate metabolism_Homo sapiens_hsa006400.12933149
80Histidine metabolism_Homo sapiens_hsa003400.12442977
81Arachidonic acid metabolism_Homo sapiens_hsa005900.12391044
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.12040290
83Pentose phosphate pathway_Homo sapiens_hsa000300.11753119
84Thyroid hormone synthesis_Homo sapiens_hsa049180.11472583
85Dilated cardiomyopathy_Homo sapiens_hsa054140.11276588
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.10998898
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.10559844
88Rap1 signaling pathway_Homo sapiens_hsa040150.10418577
89PPAR signaling pathway_Homo sapiens_hsa033200.09497970
90Prolactin signaling pathway_Homo sapiens_hsa049170.08822037
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.06501378
92* Metabolic pathways_Homo sapiens_hsa011000.06418791
93Fatty acid metabolism_Homo sapiens_hsa012120.05582613
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.03931983
95TGF-beta signaling pathway_Homo sapiens_hsa043500.03385765
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.02079683
97Complement and coagulation cascades_Homo sapiens_hsa046100.01999785
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.01854911
99Pertussis_Homo sapiens_hsa051330.01509483
100RNA degradation_Homo sapiens_hsa030180.01225791

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