UGT1A9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.46154582
2L-phenylalanine catabolic process (GO:0006559)7.46154582
3L-phenylalanine metabolic process (GO:0006558)7.12795437
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.12795437
5omega-hydroxylase P450 pathway (GO:0097267)6.88900427
6aromatic amino acid family catabolic process (GO:0009074)6.80201854
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.33744567
8tryptophan catabolic process (GO:0006569)6.22389261
9indole-containing compound catabolic process (GO:0042436)6.22389261
10indolalkylamine catabolic process (GO:0046218)6.22389261
11aminoglycoside antibiotic metabolic process (GO:0030647)6.13858201
12daunorubicin metabolic process (GO:0044597)6.13158358
13polyketide metabolic process (GO:0030638)6.13158358
14doxorubicin metabolic process (GO:0044598)6.13158358
15kynurenine metabolic process (GO:0070189)6.07663497
16bile acid biosynthetic process (GO:0006699)5.95649017
17tryptophan metabolic process (GO:0006568)5.85397821
18glyoxylate metabolic process (GO:0046487)5.79608980
19* drug metabolic process (GO:0017144)5.68059250
20urea cycle (GO:0000050)5.59041769
21urea metabolic process (GO:0019627)5.59041769
22alpha-linolenic acid metabolic process (GO:0036109)5.53296697
23high-density lipoprotein particle remodeling (GO:0034375)5.50057992
24negative regulation of fibrinolysis (GO:0051918)5.47944843
25phenylpropanoid metabolic process (GO:0009698)5.44285588
26oxidative demethylation (GO:0070989)5.41674322
27sulfur amino acid catabolic process (GO:0000098)5.40055596
28response to mercury ion (GO:0046689)5.36972545
29peptidyl-glutamic acid carboxylation (GO:0017187)5.36606983
30protein carboxylation (GO:0018214)5.36606983
31cysteine metabolic process (GO:0006534)5.34309855
32regulation of fibrinolysis (GO:0051917)5.29370388
33complement activation, alternative pathway (GO:0006957)5.28425112
34regulation of protein activation cascade (GO:2000257)5.24122186
35nitrogen cycle metabolic process (GO:0071941)5.14546113
36primary alcohol catabolic process (GO:0034310)5.12007939
37bile acid metabolic process (GO:0008206)5.11531960
38serine family amino acid catabolic process (GO:0009071)5.06971896
39aromatic amino acid family metabolic process (GO:0009072)4.93892890
40regulation of complement activation (GO:0030449)4.91038583
41ethanol metabolic process (GO:0006067)4.89304014
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.87252258
43regulation of cholesterol esterification (GO:0010872)4.82284250
44reverse cholesterol transport (GO:0043691)4.80577029
45regulation of triglyceride catabolic process (GO:0010896)4.79247975
46intestinal cholesterol absorption (GO:0030299)4.73543962
47plasma lipoprotein particle remodeling (GO:0034369)4.73040421
48protein-lipid complex remodeling (GO:0034368)4.73040421
49macromolecular complex remodeling (GO:0034367)4.73040421
50negative regulation of cholesterol transport (GO:0032375)4.72804646
51negative regulation of sterol transport (GO:0032372)4.72804646
52regulation of plasminogen activation (GO:0010755)4.70896983
53tyrosine metabolic process (GO:0006570)4.69856045
54negative regulation of blood coagulation (GO:0030195)4.69578158
55negative regulation of hemostasis (GO:1900047)4.69578158
56cellular ketone body metabolic process (GO:0046950)4.66654310
57phospholipid efflux (GO:0033700)4.62574243
58homocysteine metabolic process (GO:0050667)4.61891399
59S-adenosylmethionine metabolic process (GO:0046500)4.61097608
60alpha-amino acid catabolic process (GO:1901606)4.59208001
61acylglycerol homeostasis (GO:0055090)4.58095506
62triglyceride homeostasis (GO:0070328)4.58095506
63amino-acid betaine metabolic process (GO:0006577)4.58056399
64lysine metabolic process (GO:0006553)4.55411320
65lysine catabolic process (GO:0006554)4.55411320
66bile acid and bile salt transport (GO:0015721)4.53301978
67indolalkylamine metabolic process (GO:0006586)4.40876353
68glycine metabolic process (GO:0006544)4.36599213
69coenzyme catabolic process (GO:0009109)4.33886173
70plasma lipoprotein particle clearance (GO:0034381)4.32920079
71amine catabolic process (GO:0009310)4.32007185
72cellular biogenic amine catabolic process (GO:0042402)4.32007185
73imidazole-containing compound metabolic process (GO:0052803)4.31952231
74hormone catabolic process (GO:0042447)4.31835635
75negative regulation of coagulation (GO:0050819)4.30235613
76negative regulation of wound healing (GO:0061045)4.26018830
77drug catabolic process (GO:0042737)4.25857224
78cellular amino acid catabolic process (GO:0009063)4.24013074
79alkaloid metabolic process (GO:0009820)4.20530425
80benzene-containing compound metabolic process (GO:0042537)4.19706193
81glutamate metabolic process (GO:0006536)4.18057425
82cholesterol efflux (GO:0033344)4.16945141
83serine family amino acid metabolic process (GO:0009069)4.15490778
84ethanol oxidation (GO:0006069)4.14744305
85* cellular glucuronidation (GO:0052695)4.11311220
86low-density lipoprotein particle remodeling (GO:0034374)4.06967682
87aldehyde catabolic process (GO:0046185)4.05419507
88acute-phase response (GO:0006953)4.04804240
89ketone body metabolic process (GO:1902224)4.04149151
90drug transmembrane transport (GO:0006855)4.03904210
91fat-soluble vitamin biosynthetic process (GO:0042362)4.03759372
92cellular modified amino acid catabolic process (GO:0042219)3.96701913
93serine family amino acid biosynthetic process (GO:0009070)3.96562594
94fibrinolysis (GO:0042730)3.94040082
95plasma lipoprotein particle assembly (GO:0034377)3.93708732
96dicarboxylic acid biosynthetic process (GO:0043650)3.93639540
97arginine metabolic process (GO:0006525)3.93497566
98regulation of humoral immune response (GO:0002920)3.91398367
99negative regulation of protein activation cascade (GO:2000258)3.90042500
100epoxygenase P450 pathway (GO:0019373)3.87564371
101exogenous drug catabolic process (GO:0042738)3.82186655
102positive regulation of triglyceride lipase activity (GO:0061365)3.79927089
103positive regulation of lipoprotein lipase activity (GO:0051006)3.79927089
104blood coagulation, intrinsic pathway (GO:0007597)3.78135240
105positive regulation of hemostasis (GO:1900048)3.77069204
106positive regulation of blood coagulation (GO:0030194)3.77069204
107cofactor catabolic process (GO:0051187)3.75861427
108very-low-density lipoprotein particle assembly (GO:0034379)3.75248871
109cholesterol homeostasis (GO:0042632)3.74141591
110complement activation, classical pathway (GO:0006958)3.74141263
111phospholipid homeostasis (GO:0055091)3.73478892
112positive regulation of lipid catabolic process (GO:0050996)3.73395490
113regulation of bile acid biosynthetic process (GO:0070857)3.73206748
114organic acid catabolic process (GO:0016054)3.71889611
115carboxylic acid catabolic process (GO:0046395)3.71889611
116heme transport (GO:0015886)3.70603312
117steroid catabolic process (GO:0006706)3.70540413
118complement activation (GO:0006956)3.69712539
119sodium-independent organic anion transport (GO:0043252)3.69507302
120short-chain fatty acid metabolic process (GO:0046459)3.69060725
121cytolysis (GO:0019835)3.68565428
122sterol homeostasis (GO:0055092)3.68088981
123protein activation cascade (GO:0072376)3.67933948
124negative regulation of lipase activity (GO:0060192)3.66890701
125glycoside metabolic process (GO:0016137)3.66186638
126* xenobiotic metabolic process (GO:0006805)3.65779010
127regulation of cholesterol homeostasis (GO:2000188)3.65344737
128amino acid salvage (GO:0043102)3.64645675
129L-methionine salvage (GO:0071267)3.64645675
130L-methionine biosynthetic process (GO:0071265)3.64645675
131response to nitrosative stress (GO:0051409)3.63870133
132* glucuronate metabolic process (GO:0019585)3.63132813
133* uronic acid metabolic process (GO:0006063)3.63132813
134plasma lipoprotein particle organization (GO:0071827)3.59416988
135acetyl-CoA metabolic process (GO:0006084)3.57409524
136drug transport (GO:0015893)3.52369883
137positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.51515550
138positive regulation of coagulation (GO:0050820)3.51091344
139negative regulation of fatty acid biosynthetic process (GO:0045717)3.46727785

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.30375924
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.17389267
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.07049442
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.43971581
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.18528364
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.04805035
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.88258917
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.97007399
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.92464510
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.03417820
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.02652202
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8079674
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96527445
14TRIM28_21343339_ChIP-Seq_HEK293_Human1.74207554
15HTT_18923047_ChIP-ChIP_STHdh_Human1.55545432
16FOXA2_19822575_ChIP-Seq_HepG2_Human1.55428033
17CLOCK_20551151_ChIP-Seq_293T_Human1.45216894
18HNF4A_19822575_ChIP-Seq_HepG2_Human1.39428442
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30297808
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28180714
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27708783
22GATA1_22025678_ChIP-Seq_K562_Human1.25062440
23* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18332954
24ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12891131
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11611570
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.10432978
27* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08450627
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04116058
29ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02135131
30SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02105078
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95147327
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88958911
33RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88954507
34GATA4_25053715_ChIP-Seq_YYC3_Human0.87259897
35NFE2_27457419_Chip-Seq_LIVER_Mouse0.86620557
36TP53_18474530_ChIP-ChIP_U2OS_Human0.86182449
37* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.83551754
38ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80535308
39* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80393705
40CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.80306744
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79846953
42HNFA_21074721_ChIP-Seq_CACO-2_Human0.79703365
43AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79127165
44FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78947631
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77249710
46* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.75463655
47RARA_24833708_ChIP-Seq_LIVER_Mouse0.74560710
48SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74532304
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.74181575
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.73798337
51SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73643675
52* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71378728
53PHF8_20622853_ChIP-Seq_HELA_Human0.71294002
54NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70833397
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70833397
56ESR2_21235772_ChIP-Seq_MCF-7_Human0.70731103
57PIAS1_25552417_ChIP-Seq_VCAP_Human0.70457729
58AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69910539
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.69591439
60SOX2_21211035_ChIP-Seq_LN229_Human0.69380645
61BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67614957
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.67297694
63SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66543948
64GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.65835765
65NFYA_21822215_ChIP-Seq_K562_Human0.65238056
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.64807656
67RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64065741
68RARB_24833708_ChIP-Seq_LIVER_Mouse0.63645234
69NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.63568138
70CDX2_20551321_ChIP-Seq_CACO-2_Human0.62257370
71ZNF263_19887448_ChIP-Seq_K562_Human0.60320841
72SRY_22984422_ChIP-ChIP_TESTIS_Rat0.59977544
73CEBPB_22108803_ChIP-Seq_LS180_Human0.59708258
74GATA6_21074721_ChIP-Seq_CACO-2_Human0.59544031
75EGR1_19032775_ChIP-ChIP_M12_Human0.58092180
76PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.57012935
77SUZ12_27294783_Chip-Seq_NPCs_Mouse0.56586770
78CDX2_19796622_ChIP-Seq_MESCs_Mouse0.56291305
79ESRRB_18555785_Chip-Seq_ESCs_Mouse0.56165090
80LXR_22292898_ChIP-Seq_THP-1_Human0.55861975
81* EZH2_27294783_Chip-Seq_NPCs_Mouse0.54975800
82MYC_19915707_ChIP-ChIP_AK7_Human0.54286324
83IRF1_19129219_ChIP-ChIP_H3396_Human0.54229591
84TCF4_18268006_ChIP-ChIP_LS174T_Human0.53766024
85STAT3_1855785_ChIP-Seq_MESCs_Mouse0.53577028
86AR_20517297_ChIP-Seq_VCAP_Human0.52477569
87FOXA1_25552417_ChIP-Seq_VCAP_Human0.52342311
88STAT1_17558387_ChIP-Seq_HELA_Human0.51861820
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.51805740
90ESET_19884257_ChIP-Seq_ESCs_Mouse0.51803512
91* OCT4_18555785_Chip-Seq_ESCs_Mouse0.51368476
92FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51034595
93* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.50492130
94ESR1_21235772_ChIP-Seq_MCF-7_Human0.50397311
95* CRX_20693478_ChIP-Seq_RETINA_Mouse0.49522804
96CBX2_22325352_ChIP-Seq_293T-Rex_Human0.48908985
97RAC3_21632823_ChIP-Seq_H3396_Human0.48868874
98* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.48132385
99ERG_20517297_ChIP-Seq_VCAP_Human0.48022688
100FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.47143667
101PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.46848179
102CBP_21632823_ChIP-Seq_H3396_Human0.45672504
103GATA6_25053715_ChIP-Seq_YYC3_Human0.45666221
104PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45443074
105P53_21459846_ChIP-Seq_SAOS-2_Human0.45194359
106PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44730441
107TAF2_19829295_ChIP-Seq_ESCs_Human0.44623263
108FOXO3_23340844_ChIP-Seq_DLD1_Human0.43317739
109SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42640426
110FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41740313
111GATA1_19941826_ChIP-Seq_K562_Human0.41199952
112PPAR_26484153_Chip-Seq_NCI-H1993_Human0.40917363
113GATA2_19941826_ChIP-Seq_K562_Human0.40642157
114ESR1_20079471_ChIP-ChIP_T-47D_Human0.40444285
115SOX2_20726797_ChIP-Seq_SW620_Human0.40211104
116* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.40186200
117ERG_21242973_ChIP-ChIP_JURKAT_Human0.39852004
118* GATA1_19941827_ChIP-Seq_MEL_Mouse0.39541811
119BCAT_22108803_ChIP-Seq_LS180_Human0.39207078
120TAF15_26573619_Chip-Seq_HEK293_Human0.38716215
121STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38526089
122CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.38055780
123* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.36370932
124LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36056906
125SPI1_26923725_Chip-Seq_HPCs_Mouse0.35093991
126CDX2_22108803_ChIP-Seq_LS180_Human0.34816524
127MYC_27129775_Chip-Seq_CORNEA_Mouse0.34786551
128GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.34545027
129GATA3_24758297_ChIP-Seq_MCF-7_Human0.34221189
130E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.33976823
131OCT4_20526341_ChIP-Seq_ESCs_Human0.33896918
132NCOR_22424771_ChIP-Seq_293T_Human0.33874477

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.29657346
2MP0005360_urolithiasis7.56651147
3MP0005085_abnormal_gallbladder_physiolo6.35746619
4MP0005365_abnormal_bile_salt6.04515768
5MP0008875_abnormal_xenobiotic_pharmacok5.32689176
6MP0003806_abnormal_nucleotide_metabolis4.41651283
7MP0003252_abnormal_bile_duct3.86344753
8MP0010329_abnormal_lipoprotein_level3.54839093
9MP0009840_abnormal_foam_cell3.32406389
10MP0005083_abnormal_biliary_tract2.99368830
11MP0003195_calcinosis2.77883175
12MP0005332_abnormal_amino_acid2.71554992
13MP0001666_abnormal_nutrient_absorption2.62709375
14MP0003191_abnormal_cellular_cholesterol2.32635422
15MP0004019_abnormal_vitamin_homeostasis2.15492941
16MP0000609_abnormal_liver_physiology2.13975958
17MP0002118_abnormal_lipid_homeostasis2.08003917
18MP0002138_abnormal_hepatobiliary_system1.92248681
19MP0003868_abnormal_feces_composition1.89579720
20MP0005319_abnormal_enzyme/_coenzyme1.84824952
21MP0001764_abnormal_homeostasis1.63360568
22MP0005584_abnormal_enzyme/coenzyme_acti1.57755278
23MP0009697_abnormal_copulation1.56962903
24MP0005451_abnormal_body_composition1.47406005
25MP0004043_abnormal_pH_regulation1.47002444
26MP0003186_abnormal_redox_activity1.31687678
27MP0009643_abnormal_urine_homeostasis1.27085475
28MP0003011_delayed_dark_adaptation1.24289869
29MP0003656_abnormal_erythrocyte_physiolo1.18084536
30MP0000598_abnormal_liver_morphology1.15112911
31MP0005647_abnormal_sex_gland1.13914381
32MP0003705_abnormal_hypodermis_morpholog1.13770422
33MP0009764_decreased_sensitivity_to1.12670518
34MP0002254_reproductive_system_inflammat1.10149503
35MP0000604_amyloidosis1.04722136
36MP0009763_increased_sensitivity_to1.02111987
37MP0005636_abnormal_mineral_homeostasis0.94772275
38MP0008469_abnormal_protein_level0.93910924
39MP0010368_abnormal_lymphatic_system0.89157842
40MP0009642_abnormal_blood_homeostasis0.86853517
41MP0005408_hypopigmentation0.84910741
42MP0009765_abnormal_xenobiotic_induced0.81184866
43MP0006036_abnormal_mitochondrial_physio0.80852343
44MP0005376_homeostasis/metabolism_phenot0.80539664
45MP0002876_abnormal_thyroid_physiology0.79824359
46MP0005084_abnormal_gallbladder_morpholo0.77511447
47MP0003879_abnormal_hair_cell0.76121999
48MP0002078_abnormal_glucose_homeostasis0.75085090
49MP0004130_abnormal_muscle_cell0.72651518
50MP0003690_abnormal_glial_cell0.71474473
51MP0001915_intracranial_hemorrhage0.70650627
52MP0005334_abnormal_fat_pad0.68696146
53MP0005535_abnormal_body_temperature0.68625384
54MP0005266_abnormal_metabolism0.68228925
55MP0002822_catalepsy0.67672444
56MP0002971_abnormal_brown_adipose0.66984747
57MP0005220_abnormal_exocrine_pancreas0.66240004
58MP0004782_abnormal_surfactant_physiolog0.66138868
59MP0005670_abnormal_white_adipose0.65549327
60MP0009053_abnormal_anal_canal0.64720151
61MP0001661_extended_life_span0.62558195
62MP0005187_abnormal_penis_morphology0.61166432
63MP0001756_abnormal_urination0.57014640
64MP0005448_abnormal_energy_balance0.56754145
65MP0003329_amyloid_beta_deposits0.56472743
66MP0005464_abnormal_platelet_physiology0.54837677
67MP0006035_abnormal_mitochondrial_morpho0.54659370
68MP0003436_decreased_susceptibility_to0.54208940
69MP0010386_abnormal_urinary_bladder0.53970587
70MP0000639_abnormal_adrenal_gland0.53687666
71MP0003724_increased_susceptibility_to0.51964385
72MP0006082_CNS_inflammation0.50081976
73MP0005023_abnormal_wound_healing0.49453693
74MP0003075_altered_response_to0.48799878
75MP0008874_decreased_physiological_sensi0.48068270
76MP0002136_abnormal_kidney_physiology0.47572392
77MP0008873_increased_physiological_sensi0.46920813
78MP0003638_abnormal_response/metabolism_0.46324914
79MP0005166_decreased_susceptibility_to0.46297064
80MP0005395_other_phenotype0.45576418
81MP0002928_abnormal_bile_duct0.44240999
82MP0003718_maternal_effect0.43619077
83MP0003959_abnormal_lean_body0.43580732
84MP0005248_abnormal_Harderian_gland0.42628620
85MP0008872_abnormal_physiological_respon0.42257216
86MP0003953_abnormal_hormone_level0.40431164
87MP0004381_abnormal_hair_follicle0.39059084
88MP0003300_gastrointestinal_ulcer0.37944531
89MP0002089_abnormal_postnatal_growth/wei0.37467788
90MP0002090_abnormal_vision0.35931696
91MP0001765_abnormal_ion_homeostasis0.35459227
92MP0001845_abnormal_inflammatory_respons0.34820235
93MP0002796_impaired_skin_barrier0.34774845
94MP0002837_dystrophic_cardiac_calcinosis0.34345883
95MP0000249_abnormal_blood_vessel0.33261507
96MP0009115_abnormal_fat_cell0.33175749
97MP0001853_heart_inflammation0.33105337
98MP0004883_abnormal_blood_vessel0.32830588
99MP0005666_abnormal_adipose_tissue0.32257920
100MP0009672_abnormal_birth_weight0.31603681
101MP0000579_abnormal_nail_morphology0.31513123
102MP0002132_abnormal_respiratory_system0.30003028
103MP0000230_abnormal_systemic_arterial0.29968365
104MP0005167_abnormal_blood-brain_barrier0.29555321
105MP0005058_abnormal_lysosome_morphology0.28991526
106MP0002168_other_aberrant_phenotype0.28513732
107MP0001243_abnormal_dermal_layer0.28135047
108MP0008961_abnormal_basal_metabolism0.27852751
109MP0000920_abnormal_myelination0.27784088
110MP0002970_abnormal_white_adipose0.27573276
111MP0005164_abnormal_response_to0.27009337
112MP0004264_abnormal_extraembryonic_tissu0.26332939
113MP0009785_altered_susceptibility_to0.26296684
114MP0001881_abnormal_mammary_gland0.26021788
115MP0002282_abnormal_trachea_morphology0.25751427
116MP0002135_abnormal_kidney_morphology0.24865151
117MP0001944_abnormal_pancreas_morphology0.22787268
118MP0005197_abnormal_uvea_morphology0.22441573
119MP0002249_abnormal_larynx_morphology0.22299427
120MP0003632_abnormal_nervous_system0.22129995
121MP0000467_abnormal_esophagus_morphology0.19983315
122MP0003943_abnormal_hepatobiliary_system0.19946178
123MP0001851_eye_inflammation0.17809207

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.38673689
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.34758352
3Intrahepatic cholestasis (HP:0001406)7.26929074
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.64144011
5Prolonged partial thromboplastin time (HP:0003645)6.56242572
6Hypobetalipoproteinemia (HP:0003563)6.50668904
7Xanthomatosis (HP:0000991)6.18511576
8Hyperlipoproteinemia (HP:0010980)5.53704663
9Complement deficiency (HP:0004431)5.40056523
10Joint hemorrhage (HP:0005261)4.82514970
11Hypolipoproteinemia (HP:0010981)4.79247156
12Hyperammonemia (HP:0001987)4.56770991
13Hyperglycinemia (HP:0002154)4.41992218
14Epidermoid cyst (HP:0200040)4.41751014
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.37884000
16Abnormality of the common coagulation pathway (HP:0010990)4.36611330
17Fat malabsorption (HP:0002630)4.23280371
18Ketosis (HP:0001946)4.18265418
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.17032724
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.12573260
21Abnormality of methionine metabolism (HP:0010901)4.10541538
22Hypoalphalipoproteinemia (HP:0003233)4.10265266
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.02261643
24Abnormality of complement system (HP:0005339)3.97763776
25Hyperglycinuria (HP:0003108)3.93153167
26Abnormality of serine family amino acid metabolism (HP:0010894)3.89441815
27Abnormality of glycine metabolism (HP:0010895)3.89441815
28Hypoglycemic coma (HP:0001325)3.88899928
29Abnormality of pyrimidine metabolism (HP:0004353)3.78743054
30Conjugated hyperbilirubinemia (HP:0002908)3.78003096
31Abnormality of the intrinsic pathway (HP:0010989)3.76493704
32Hypercholesterolemia (HP:0003124)3.61488507
33Abnormality of fatty-acid metabolism (HP:0004359)3.37092442
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.32674684
35Increased circulating renin level (HP:0000848)3.32259651
36Hyperbilirubinemia (HP:0002904)3.31446684
37Steatorrhea (HP:0002570)3.22383880
38Delayed CNS myelination (HP:0002188)3.14953991
39Abnormality of nucleobase metabolism (HP:0010932)3.08707307
40Hyperphosphaturia (HP:0003109)3.07026476
41Abnormality of serum amino acid levels (HP:0003112)3.01529377
42Osteomalacia (HP:0002749)3.01328278
43Ketoacidosis (HP:0001993)2.97064513
44Myocardial infarction (HP:0001658)2.94878822
45Hypochromic microcytic anemia (HP:0004840)2.94283243
46Spontaneous abortion (HP:0005268)2.93003396
47Hepatocellular carcinoma (HP:0001402)2.89608619
48Metabolic alkalosis (HP:0200114)2.86828508
49Systemic lupus erythematosus (HP:0002725)2.83521938
50Metabolic acidosis (HP:0001942)2.75894700
51Abnormality of urine glucose concentration (HP:0011016)2.75152475
52Glycosuria (HP:0003076)2.75152475
53Abnormality of purine metabolism (HP:0004352)2.73689433
54Dicarboxylic aciduria (HP:0003215)2.70627053
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.70627053
56Skin nodule (HP:0200036)2.69952959
57Hypokalemic alkalosis (HP:0001949)2.68306706
58Vascular calcification (HP:0004934)2.67125716
59Lethargy (HP:0001254)2.63198693
60Abnormal urine phosphate concentration (HP:0012599)2.60821744
61Recurrent gram-negative bacterial infections (HP:0005420)2.58315770
62Hyperactive renin-angiotensin system (HP:0000841)2.56209543
63Reduced antithrombin III activity (HP:0001976)2.50147260
64Hypoglycemic seizures (HP:0002173)2.49280717
65Acanthocytosis (HP:0001927)2.48185501
66Glomerulonephritis (HP:0000099)2.47017655
67Cerebral edema (HP:0002181)2.45153847
68Spastic diplegia (HP:0001264)2.43329646
69Malnutrition (HP:0004395)2.40762163
70Abnormal gallbladder morphology (HP:0012437)2.37294632
71Gout (HP:0001997)2.36887024
72Mitral stenosis (HP:0001718)2.36511721
73Cardiovascular calcification (HP:0011915)2.36348311
74Neonatal onset (HP:0003623)2.33367823
75Elevated alkaline phosphatase (HP:0003155)2.32968971
76Cholelithiasis (HP:0001081)2.32818966
77Irritability (HP:0000737)2.31965873
78Cholecystitis (HP:0001082)2.26201115
79Abnormal gallbladder physiology (HP:0012438)2.26201115
80Sensorimotor neuropathy (HP:0007141)2.24162681
81Esophageal varix (HP:0002040)2.23384575
82Purpura (HP:0000979)2.23237674
83Hypomagnesemia (HP:0002917)2.20433090
84Amyloidosis (HP:0011034)2.18458882
85Menorrhagia (HP:0000132)2.18128670
86Abnormality of the Achilles tendon (HP:0005109)2.17415194
87Pancreatitis (HP:0001733)2.16255737
88Abnormal platelet function (HP:0011869)2.15945008
89Impaired platelet aggregation (HP:0003540)2.15945008
90Late onset (HP:0003584)2.14300420
91Generalized aminoaciduria (HP:0002909)2.14119197
92Gingival bleeding (HP:0000225)2.13823763
93Abnormality of alkaline phosphatase activity (HP:0004379)2.12398192
94Brushfield spots (HP:0001088)2.11249900
95Vomiting (HP:0002013)2.11053282
96Opisthotonus (HP:0002179)2.08766341
97Increased mean platelet volume (HP:0011877)2.05895382
98Arthropathy (HP:0003040)2.05354460
99Hemorrhage of the eye (HP:0011885)2.04920313
100Thrombophlebitis (HP:0004418)2.03547296
101Hypophosphatemia (HP:0002148)2.01563626
102Enlarged kidneys (HP:0000105)2.01365532
103Hyperinsulinemic hypoglycemia (HP:0000825)1.98403192
104Rickets (HP:0002748)1.96498026
105Abnormality of the gallbladder (HP:0005264)1.94794360
106Pulmonary embolism (HP:0002204)1.94612927
107Poikilocytosis (HP:0004447)1.93461254
108Abnormal cartilage morphology (HP:0002763)1.92499671
109Bifid scrotum (HP:0000048)1.91397368
110Abnormal urine output (HP:0012590)1.90391598
111Alkalosis (HP:0001948)1.90131846
112Facial shape deformation (HP:0011334)1.89351511
113Potter facies (HP:0002009)1.89351511
114Abnormality of iron homeostasis (HP:0011031)1.88847905
115Abnormality of proline metabolism (HP:0010907)1.88118631
116Hydroxyprolinuria (HP:0003080)1.88118631
117Renal cortical cysts (HP:0000803)1.87195048
118Abnormality of transition element cation homeostasis (HP:0011030)1.86793305
119Fair hair (HP:0002286)1.85855088
120Abnormal platelet volume (HP:0011876)1.85047102
121Hypokalemia (HP:0002900)1.84603712
122Abnormal enzyme/coenzyme activity (HP:0012379)1.84293445
123Hypophosphatemic rickets (HP:0004912)1.84155963
124Abnormality of chloride homeostasis (HP:0011422)1.83486626
125Abnormality of magnesium homeostasis (HP:0004921)1.83383224
126Status epilepticus (HP:0002133)1.79058357
127Elevated hepatic transaminases (HP:0002910)1.79047253
128Increased serum ferritin (HP:0003281)1.78426688
129Abnormality of vitamin metabolism (HP:0100508)1.78283609
130Nephritis (HP:0000123)1.76412858
131Focal segmental glomerulosclerosis (HP:0000097)1.75896868
132Proximal tubulopathy (HP:0000114)1.73524801

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK38.36546697
2BCKDK6.97940718
3OXSR14.99288100
4ERN14.50394620
5SIK14.47420048
6FGFR44.46667340
7TAOK33.20066695
8INSRR2.72106072
9ERBB42.70437273
10MST1R2.69078271
11PKN22.16672225
12MAP2K42.16201114
13PRPF4B2.07221249
14PIK3CG1.99964942
15TYK21.96220543
16FLT31.92546519
17MAPK111.73720269
18ABL21.65106570
19FRK1.59089626
20MAP3K71.56662459
21NEK91.51490242
22TRIB31.50290490
23LATS11.47543321
24STK391.46909240
25PTK61.44839821
26WNK41.43156360
27MAP3K141.42938689
28TBK11.36120844
29DAPK21.28312057
30JAK21.27396156
31MAP3K121.24498984
32KDR1.23721440
33FGFR21.16619108
34PRKAA21.14812965
35JAK11.11352027
36GRK61.08609544
37MAP3K101.06810814
38MAP2K31.01264216
39PINK10.99937819
40MAPK40.97394621
41SCYL20.93820922
42NTRK10.93649207
43MET0.92097738
44ERBB20.90249674
45PRKCZ0.89354984
46PDGFRA0.89238226
47MAP3K30.85421382
48MAP3K110.84111305
49IRAK30.83126527
50MYLK0.83094965
51CDK60.82349851
52CAMK1D0.78752286
53DYRK1B0.76916143
54CSK0.76909829
55TIE10.76783374
56IKBKE0.76347327
57MAPK120.75456006
58MAPK150.74472375
59PRKACG0.74207489
60EPHB10.73850532
61NTRK30.70605658
62MATK0.68390175
63STK38L0.67813582
64TGFBR20.67275234
65MAP2K60.66126846
66GSK3A0.66122662
67CAMK2G0.65707514
68LMTK20.65624785
69CSF1R0.64856651
70PRKAA10.61443027
71PBK0.61200947
72MAPK70.58641534
73EPHA30.58076869
74PDPK10.57412154
75MAP3K130.56194449
76PRKCQ0.55383588
77DDR20.55142277
78PRKACA0.55077826
79ZAP700.54127494
80RIPK10.52527209
81ACVR1B0.52325232
82SGK30.52309916
83TAOK20.52001205
84MAP2K20.51750120
85FGFR30.50854531
86CAMKK20.50791334
87PDK20.49807172
88FER0.47673637
89MAP3K50.46862532
90SGK10.46460890
91STK380.45897124
92IGF1R0.45763401
93MAPKAPK30.45421763
94PRKG10.44448771
95PIM20.44214526
96NLK0.43262148
97GRK10.43079329
98KSR20.43025653
99PRKCB0.42862852
100MAP2K10.42252007
101PTK20.41929848
102PIK3CA0.40758990
103STK160.39778821
104SRC0.39501666
105PDK10.39269478
106EIF2AK10.37697829
107RPS6KA30.36398795
108EPHA40.35401209
109ARAF0.34698239
110CDK40.34494634
111EGFR0.33663810
112CSNK1G10.33351027
113SGK20.32974852
114CAMK40.32119032
115IRAK20.31500345
116RET0.30923179
117PRKCA0.30784539
118CSNK1A10.30554355
119MUSK0.30510568
120PRKCG0.30137733
121MAP3K10.29229388
122TESK10.28999918
123PKN10.28812913
124CDC42BPA0.28624062
125CHUK0.28366724
126MAP4K10.27106584
127KIT0.26574831
128CSNK1D0.26436860
129IKBKB0.26217421
130MAP3K60.25640308
131MAP3K20.25521325
132ABL10.25362938
133PRKCD0.25283193
134CAMK1G0.24926799
135IRAK10.24565992
136ICK0.22120409
137SGK2230.21903042
138SGK4940.21903042
139MTOR0.21519679

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.51802256
2Nitrogen metabolism_Homo sapiens_hsa009103.45866891
3* Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33171119
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.23312836
5Arginine biosynthesis_Homo sapiens_hsa002202.98605268
6Tryptophan metabolism_Homo sapiens_hsa003802.77212834
7Complement and coagulation cascades_Homo sapiens_hsa046102.71473617
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.64798380
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62859382
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49401919
11Fatty acid degradation_Homo sapiens_hsa000712.47000223
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.41376178
13* Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23009399
14* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.22806884
15Butanoate metabolism_Homo sapiens_hsa006502.19985803
16Peroxisome_Homo sapiens_hsa041462.06763685
17* Chemical carcinogenesis_Homo sapiens_hsa052042.03545863
18* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.01826714
19Caffeine metabolism_Homo sapiens_hsa002322.01565616
20* Steroid hormone biosynthesis_Homo sapiens_hsa001402.00645249
21Histidine metabolism_Homo sapiens_hsa003401.95767236
22Propanoate metabolism_Homo sapiens_hsa006401.89793914
23PPAR signaling pathway_Homo sapiens_hsa033201.84015545
24Staphylococcus aureus infection_Homo sapiens_hsa051501.77057715
25Fatty acid metabolism_Homo sapiens_hsa012121.76030134
26* Retinol metabolism_Homo sapiens_hsa008301.74473891
27* Drug metabolism - other enzymes_Homo sapiens_hsa009831.72823246
28beta-Alanine metabolism_Homo sapiens_hsa004101.72486396
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70878392
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.66453819
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63912331
32Sulfur metabolism_Homo sapiens_hsa009201.58332940
33Phenylalanine metabolism_Homo sapiens_hsa003601.55752469
34Selenocompound metabolism_Homo sapiens_hsa004501.55217386
35Bile secretion_Homo sapiens_hsa049761.51854496
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47437608
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45864934
38Tyrosine metabolism_Homo sapiens_hsa003501.44871175
39Pyruvate metabolism_Homo sapiens_hsa006201.32409555
40Fatty acid elongation_Homo sapiens_hsa000621.29760529
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.25901959
42Fat digestion and absorption_Homo sapiens_hsa049751.22003455
43ABC transporters_Homo sapiens_hsa020101.21733493
44Folate biosynthesis_Homo sapiens_hsa007901.21431583
45* Starch and sucrose metabolism_Homo sapiens_hsa005001.19829343
46Biosynthesis of amino acids_Homo sapiens_hsa012301.14592195
47Steroid biosynthesis_Homo sapiens_hsa001001.12897055
48Carbon metabolism_Homo sapiens_hsa012001.11848298
49Sulfur relay system_Homo sapiens_hsa041221.05303136
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.02296618
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.00490171
52Vitamin B6 metabolism_Homo sapiens_hsa007500.99041409
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97574581
54Arginine and proline metabolism_Homo sapiens_hsa003300.94271436
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87208108
56Vitamin digestion and absorption_Homo sapiens_hsa049770.85638252
57* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85477795
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81195138
59Lysine degradation_Homo sapiens_hsa003100.77026096
60One carbon pool by folate_Homo sapiens_hsa006700.73918036
61Glutathione metabolism_Homo sapiens_hsa004800.71545442
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68576364
63Glycerolipid metabolism_Homo sapiens_hsa005610.67011613
64Pentose phosphate pathway_Homo sapiens_hsa000300.59479111
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51781668
66* Metabolic pathways_Homo sapiens_hsa011000.46672472
67Fatty acid biosynthesis_Homo sapiens_hsa000610.46564681
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44353784
69Prion diseases_Homo sapiens_hsa050200.38879177
70Linoleic acid metabolism_Homo sapiens_hsa005910.36209569
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33292635
72Galactose metabolism_Homo sapiens_hsa000520.27515207
73Fructose and mannose metabolism_Homo sapiens_hsa000510.26909715
74Insulin resistance_Homo sapiens_hsa049310.21297293
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.21106166
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16716174
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.15038909
78Glucagon signaling pathway_Homo sapiens_hsa049220.05087659
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.04182457
80Other glycan degradation_Homo sapiens_hsa005110.00223688
81Protein digestion and absorption_Homo sapiens_hsa04974-0.2520651
82Amoebiasis_Homo sapiens_hsa05146-0.2349435
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.2241207
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2196346
85Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2149660
86Pertussis_Homo sapiens_hsa05133-0.2091981
87Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1992989
88N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1875466
89Ether lipid metabolism_Homo sapiens_hsa00565-0.1833169
90Type II diabetes mellitus_Homo sapiens_hsa04930-0.1816475
91Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1741101
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1738895
93Renin-angiotensin system_Homo sapiens_hsa04614-0.1723333
94Hepatitis C_Homo sapiens_hsa05160-0.1608574
95Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1364934
96Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1351505
97Insulin signaling pathway_Homo sapiens_hsa04910-0.1335649
98Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1044657
99Regulation of autophagy_Homo sapiens_hsa04140-0.0993758
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0983282
101Mineral absorption_Homo sapiens_hsa04978-0.0980571
102African trypanosomiasis_Homo sapiens_hsa05143-0.0962616
103Serotonergic synapse_Homo sapiens_hsa04726-0.0673265
104Sphingolipid metabolism_Homo sapiens_hsa00600-0.0595227
105Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0531750
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0337024
107AMPK signaling pathway_Homo sapiens_hsa04152-0.0306276

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