UGT1A8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)7.56120097
2polyketide metabolic process (GO:0030638)7.56120097
3doxorubicin metabolic process (GO:0044598)7.56120097
4aminoglycoside antibiotic metabolic process (GO:0030647)6.69405771
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.82277221
6bundle of His cell to Purkinje myocyte communication (GO:0086069)5.78556094
7primary alcohol catabolic process (GO:0034310)5.49669860
8bile acid and bile salt transport (GO:0015721)5.40092919
9sulfate transmembrane transport (GO:1902358)5.16325440
10response to nitrosative stress (GO:0051409)4.97854264
11phenol-containing compound catabolic process (GO:0019336)4.96822231
12GDP-mannose metabolic process (GO:0019673)4.76672186
13desmosome organization (GO:0002934)4.63482683
14regulation of guanylate cyclase activity (GO:0031282)4.53211683
15G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.53032482
16viral transcription (GO:0019083)4.44062293
17ribosomal small subunit biogenesis (GO:0042274)4.37344059
18glycoside metabolic process (GO:0016137)4.36103797
19sulfate transport (GO:0008272)4.34161556
20quinone metabolic process (GO:1901661)4.33563189
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.33285531
22neutrophil activation involved in immune response (GO:0002283)4.33013067
233-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.24688573
24purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.24688573
25* cellular glucuronidation (GO:0052695)4.21711247
26* glucuronate metabolic process (GO:0019585)4.19123425
27* uronic acid metabolic process (GO:0006063)4.19123425
28translational termination (GO:0006415)4.17130008
29calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.12150445
30renal system process involved in regulation of blood volume (GO:0001977)4.10764408
31cyclooxygenase pathway (GO:0019371)4.08983970
32drug transmembrane transport (GO:0006855)4.08619772
33phospholipid efflux (GO:0033700)4.05306536
34respiratory burst (GO:0045730)4.02818365
35* flavonoid metabolic process (GO:0009812)3.99803986
36triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.95533761
37gap junction assembly (GO:0016264)3.90508199
38response to peptidoglycan (GO:0032494)3.88311203
39macrophage activation involved in immune response (GO:0002281)3.86905634
40angiotensin maturation (GO:0002003)3.85424123
41regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.84337759
42epoxygenase P450 pathway (GO:0019373)3.83658560
43positive regulation of fatty acid beta-oxidation (GO:0032000)3.81338276
44protein targeting to ER (GO:0045047)3.78532555
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.77038667
46cotranslational protein targeting to membrane (GO:0006613)3.75747977
47protein localization to endoplasmic reticulum (GO:0070972)3.71752524
48establishment of protein localization to endoplasmic reticulum (GO:0072599)3.64740024
49regulation of respiratory burst (GO:0060263)3.61030188
50ethanol oxidation (GO:0006069)3.58109238
51cranial nerve development (GO:0021545)3.57235446
52positive regulation of cellular amine metabolic process (GO:0033240)3.55956588
53positive regulation of respiratory burst (GO:0060267)3.54139521
54glutathione biosynthetic process (GO:0006750)3.53717372
55regulation of cholesterol esterification (GO:0010872)3.53239123
56* drug metabolic process (GO:0017144)3.52689887
57regulation of B cell receptor signaling pathway (GO:0050855)3.52687360
58retinal ganglion cell axon guidance (GO:0031290)3.52675698
59glutathione derivative biosynthetic process (GO:1901687)3.46446588
60glutathione derivative metabolic process (GO:1901685)3.46446588
61intestinal absorption (GO:0050892)3.45674843
62regulation of vitamin metabolic process (GO:0030656)3.44778107
63O-glycan processing (GO:0016266)3.42509980
64translational elongation (GO:0006414)3.42112427
65intestinal cholesterol absorption (GO:0030299)3.41924976
66viral life cycle (GO:0019058)3.41815797
67regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.41259050
68endocrine process (GO:0050886)3.41259050
69regulation of systemic arterial blood pressure by hormone (GO:0001990)3.41259050
70intestinal epithelial cell development (GO:0060576)3.36758213
71oligosaccharide catabolic process (GO:0009313)3.36178470
72drug transport (GO:0015893)3.35786986
73nonribosomal peptide biosynthetic process (GO:0019184)3.34857855
74ATP synthesis coupled proton transport (GO:0015986)3.34123795
75energy coupled proton transport, down electrochemical gradient (GO:0015985)3.34123795
76cellular protein complex disassembly (GO:0043624)3.32063450
77urea metabolic process (GO:0019627)3.31747514
78urea cycle (GO:0000050)3.31747514
79microglial cell activation (GO:0001774)3.30887043
80glucocorticoid biosynthetic process (GO:0006704)3.29393518
81hydrogen peroxide biosynthetic process (GO:0050665)3.27887710
82negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.25371656
83bicarbonate transport (GO:0015701)3.23243864
84renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.20446297
85lipopolysaccharide-mediated signaling pathway (GO:0031663)3.17019216
86ribosomal large subunit biogenesis (GO:0042273)3.15238226
87positive regulation of guanylate cyclase activity (GO:0031284)3.15088257
88very-low-density lipoprotein particle assembly (GO:0034379)3.14380854
89positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.13539735
90regulation of systemic arterial blood pressure (GO:0003073)3.10116001
91ethanol metabolic process (GO:0006067)3.09934283
92positive regulation of fatty acid oxidation (GO:0046321)3.09449882
93primary alcohol metabolic process (GO:0034308)3.08375999
94regulation of triglyceride catabolic process (GO:0010896)3.08230754
95parturition (GO:0007567)3.06970841
96nitrogen cycle metabolic process (GO:0071941)3.06509337
97negative regulation of response to reactive oxygen species (GO:1901032)3.04583753
98lipoprotein metabolic process (GO:0042157)3.02994716
99cholesterol efflux (GO:0033344)3.02928553
100sulfur compound transport (GO:0072348)3.01656408
101cellular response to cadmium ion (GO:0071276)2.99510085
102positive regulation of Cdc42 GTPase activity (GO:0043089)2.98669890
103positive regulation of monocyte chemotaxis (GO:0090026)2.97069664
104cysteine metabolic process (GO:0006534)2.95524586
105plasma lipoprotein particle remodeling (GO:0034369)2.95156006
106protein-lipid complex remodeling (GO:0034368)2.95156006
107macromolecular complex remodeling (GO:0034367)2.95156006
108positive regulation by symbiont of host defense response (GO:0052509)2.94634691
109modulation by symbiont of host defense response (GO:0052031)2.94634691
110modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.94634691
111modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.94634691
112positive regulation by organism of defense response of other organism involved in symbiotic interact2.94634691
113modulation by symbiont of host immune response (GO:0052553)2.94634691
114neurotransmitter catabolic process (GO:0042135)2.93738516
115sulfur amino acid catabolic process (GO:0000098)2.93578032
116transcytosis (GO:0045056)2.92713728
117sperm capacitation (GO:0048240)2.92592752
118production of molecular mediator involved in inflammatory response (GO:0002532)2.92052713
119reverse cholesterol transport (GO:0043691)2.91473630
120fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.90836499
121fat-soluble vitamin biosynthetic process (GO:0042362)2.90715601
122plasma lipoprotein particle assembly (GO:0034377)2.90458203
123neurotransmitter biosynthetic process (GO:0042136)2.90155061
124nucleotide-sugar biosynthetic process (GO:0009226)2.89885626
125nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.89770783
126reactive oxygen species biosynthetic process (GO:1903409)2.89476897
127response to muramyl dipeptide (GO:0032495)2.89061323
128cellular ketone body metabolic process (GO:0046950)2.88957121
129response to food (GO:0032094)2.88597776
130positive regulation of chemokine biosynthetic process (GO:0045080)2.88439542
131oligosaccharide biosynthetic process (GO:0009312)2.88155118
132one-carbon metabolic process (GO:0006730)2.87650560
133hormone catabolic process (GO:0042447)2.86276342
134high-density lipoprotein particle remodeling (GO:0034375)2.85543022
135superoxide anion generation (GO:0042554)2.85165383
136disruption of cells of other organism (GO:0044364)2.82261006
137killing of cells of other organism (GO:0031640)2.82261006
138macrophage activation (GO:0042116)2.82043894
139protein-lipid complex assembly (GO:0065005)2.81446375
140plasma lipoprotein particle clearance (GO:0034381)2.79422822
141citrulline biosynthetic process (GO:0019240)2.79275869
142positive regulation of interferon-alpha production (GO:0032727)2.79126151
143cytidine deamination (GO:0009972)2.78891646
144cytidine metabolic process (GO:0046087)2.78891646
145cytidine catabolic process (GO:0006216)2.78891646
146low-density lipoprotein particle remodeling (GO:0034374)2.78764221
147cellular response to zinc ion (GO:0071294)2.78728924
148regulation of interleukin-8 secretion (GO:2000482)2.76928185
149digestion (GO:0007586)2.76789360
150regulation of cholesterol storage (GO:0010885)2.76661716
151receptor guanylyl cyclase signaling pathway (GO:0007168)2.75745448
152xenobiotic catabolic process (GO:0042178)2.75077342
153maintenance of gastrointestinal epithelium (GO:0030277)2.74081004
154regulation of hydrogen peroxide metabolic process (GO:0010310)2.74016518
155nucleoside diphosphate biosynthetic process (GO:0009133)2.73481847
156arginine metabolic process (GO:0006525)2.73157067
157regulation of hydrogen peroxide-induced cell death (GO:1903205)2.73049686
158regulation of podosome assembly (GO:0071801)2.72723781
159positive regulation of lipid catabolic process (GO:0050996)2.72083953
160myeloid cell activation involved in immune response (GO:0002275)2.70858919
161granulocyte activation (GO:0036230)2.70784654
162plasma lipoprotein particle organization (GO:0071827)2.69733378
163G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.67681147
164immunoglobulin mediated immune response (GO:0016064)2.65843143
165protein-lipid complex subunit organization (GO:0071825)2.65837789
166neutrophil activation (GO:0042119)2.65791104
167purinergic nucleotide receptor signaling pathway (GO:0035590)2.64727554
168regulation of monocyte chemotaxis (GO:0090025)2.62929334
169glyoxylate metabolic process (GO:0046487)2.62243430
170negative regulation of cholesterol transport (GO:0032375)2.61374078
171negative regulation of sterol transport (GO:0032372)2.61374078
172glutathione metabolic process (GO:0006749)2.60273450
173positive regulation of blood coagulation (GO:0030194)2.60227599
174positive regulation of hemostasis (GO:1900048)2.60227599
175regulation of interferon-alpha production (GO:0032647)2.58577668
176response to fungus (GO:0009620)2.55973823
177erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.54111519
178L-phenylalanine metabolic process (GO:0006558)2.54111519
179amyloid precursor protein catabolic process (GO:0042987)2.51362143
180complement activation, alternative pathway (GO:0006957)2.51248735
181regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.51130525
182fructose metabolic process (GO:0006000)2.51061037
183positive regulation of antigen processing and presentation (GO:0002579)2.48297711
184positive regulation of cellular amide metabolic process (GO:0034250)2.47714258
185regulation of heterotypic cell-cell adhesion (GO:0034114)2.47593382
186endosome to pigment granule transport (GO:0043485)2.47468346
187endosome to melanosome transport (GO:0035646)2.47468346
188regulation of mononuclear cell migration (GO:0071675)2.46918011
189cellular response to exogenous dsRNA (GO:0071360)2.45862365
190regulation of interferon-beta biosynthetic process (GO:0045357)2.45567557

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.93815862
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.91354793
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.67274699
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.37493047
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.15306355
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.93594317
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.67298182
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.38189743
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.24722697
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.22504459
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.14173376
12TP63_17297297_ChIP-ChIP_HaCaT_Human3.02074373
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.00797885
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.94271396
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.93293210
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.87110966
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.67298624
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.61089364
19* IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.58015938
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.55929700
21AR_21909140_ChIP-Seq_LNCAP_Human2.54182281
22ZNF263_19887448_ChIP-Seq_K562_Human2.48607505
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.40370060
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.37218775
25CDX2_20551321_ChIP-Seq_CACO-2_Human2.35244689
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.31723538
27ESR1_15608294_ChIP-ChIP_MCF-7_Human2.30772533
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.26084642
29PPAR_26484153_Chip-Seq_NCI-H1993_Human2.22367142
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.19364086
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.15801376
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.14337641
33ESR1_21235772_ChIP-Seq_MCF-7_Human2.13851892
34PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.07726831
35ESR2_21235772_ChIP-Seq_MCF-7_Human2.06101463
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.99209850
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.92714755
38RACK7_27058665_Chip-Seq_MCF-7_Human1.77967353
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.76734373
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75942937
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.74102007
42PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.71381210
43EGR1_19032775_ChIP-ChIP_M12_Human1.69491577
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.68297375
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67134351
46VDR_24763502_ChIP-Seq_THP-1_Human1.66084126
47SCL_19346495_ChIP-Seq_HPC-7_Human1.64417086
48HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.64073140
49KLF5_25053715_ChIP-Seq_YYC3_Human1.62830201
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.59806373
51ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.58118913
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56853952
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55694134
54VDR_24787735_ChIP-Seq_THP-1_Human1.55629318
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54176094
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.54003447
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.53837006
58TRIM28_21343339_ChIP-Seq_HEK293_Human1.53398496
59PU_27001747_Chip-Seq_BMDM_Mouse1.52287345
60FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.50904586
61* SOX2_20726797_ChIP-Seq_SW620_Human1.44865818
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44641953
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44167382
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43491101
65* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.41535031
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41340726
67GATA3_24758297_ChIP-Seq_MCF-7_Human1.40325545
68SPI1_23547873_ChIP-Seq_NB4_Human1.40281939
69RUNX1_27514584_Chip-Seq_MCF-7_Human1.40256993
70AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.39903944
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39793029
72KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38622018
73GABP_17652178_ChIP-ChIP_JURKAT_Human1.33937635
74* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.30175411
75* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.30175411
76IRF1_19129219_ChIP-ChIP_H3396_Human1.29815196
77STAT1_20625510_ChIP-Seq_HELA_Human1.29713984
78CLOCK_20551151_ChIP-Seq_293T_Human1.29515071
79STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28648099
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28291526
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25986671
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24815139
83ELF5_23300383_ChIP-Seq_T47D_Human1.24127341
84RUNX1_22412390_ChIP-Seq_EML_Mouse1.23462364
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23298066
86FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23282855
87NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20555194
88ELK1_22589737_ChIP-Seq_MCF10A_Human1.20168623
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.17837780
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17769862
91CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17102835
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16904473
93FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15605636
94* HNF4A_19822575_ChIP-Seq_HepG2_Human1.15390649
95CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13925586
96ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13368993
97SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12975861
98TET1_21451524_ChIP-Seq_MESCs_Mouse1.12503572
99CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12470628
100FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.11986428
101STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11738761
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09314815
103TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08907116
104SOX2_21211035_ChIP-Seq_LN229_Human1.08142624
105GATA4_25053715_ChIP-Seq_YYC3_Human1.08103320
106MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07581485
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07190711
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06147927
109RUNX_20019798_ChIP-Seq_JUKART_Human1.05892937
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05733958
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02754692
112ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00583310
113FOXA1_25552417_ChIP-Seq_VCAP_Human0.99719775
114P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99544563
115FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99110046
116CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97366912
117EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.97217133
118LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96999080
119GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96443938
120PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94815215
121TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94579615
122RAD21_21589869_ChIP-Seq_MESCs_Mouse0.92719122
123GATA6_25053715_ChIP-Seq_YYC3_Human0.92463046
124NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91627802
125NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91627802
126CSB_26484114_Chip-Seq_FIBROBLAST_Human0.90578042
127CEBPB_22108803_ChIP-Seq_LS180_Human0.89863490
128MYB_26560356_Chip-Seq_TH2_Human0.89536128
129TCF4_18268006_ChIP-ChIP_LS174T_Human0.89229451
130FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88841020
131* FOXA1_25329375_ChIP-Seq_VCAP_Human0.87938737
132* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87938737
133KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87162281
134P53_21459846_ChIP-Seq_SAOS-2_Human0.87151491
135GATA2_19941826_ChIP-Seq_K562_Human0.86852897
136ATF3_27146783_Chip-Seq_COLON_Human0.86148474
137* TP63_22573176_ChIP-Seq_HFKS_Human0.84226514
138E2F1_20622854_ChIP-Seq_HELA_Human0.83227818
139CDX2_22108803_ChIP-Seq_LS180_Human0.82345986
140BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.81333914
141PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81198254
142STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80760780
143MAF_26560356_Chip-Seq_TH1_Human0.80443844
144VDR_21846776_ChIP-Seq_THP-1_Human0.80236880
145NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79735716
146TDRD3_21172665_ChIP-Seq_MCF-7_Human0.79607130
147HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.79379848
148MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.79193091
149LXR_22292898_ChIP-Seq_THP-1_Human0.78658968
150UTX_26944678_Chip-Seq_JUKART_Human0.78649431
151SPI1_23127762_ChIP-Seq_K562_Human0.78419945
152P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.78397932
153CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77290754
154ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77243069
155PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.77132788
156PHF8_20622854_ChIP-Seq_HELA_Human0.76916500
157JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.76349799
158SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.76191702
159SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74854659
160GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74280906
161GATA1_22025678_ChIP-Seq_K562_Human0.74279804
162GATA3_26560356_Chip-Seq_TH2_Human0.73369013
163NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.72774661
164FOXO3_23340844_ChIP-Seq_DLD1_Human0.71442438
165BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70160421

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.64775007
2MP0002139_abnormal_hepatobiliary_system4.26665796
3MP0001835_abnormal_antigen_presentation3.76501625
4MP0003191_abnormal_cellular_cholesterol3.65839578
5MP0003436_decreased_susceptibility_to3.54909663
6MP0002938_white_spotting3.32308350
7MP0004043_abnormal_pH_regulation3.08187648
8MP0009840_abnormal_foam_cell3.01639374
9MP0002148_abnormal_hypersensitivity_rea2.96759322
10MP0009785_altered_susceptibility_to2.96488590
11MP0005085_abnormal_gallbladder_physiolo2.87103873
12MP0004264_abnormal_extraembryonic_tissu2.81616948
13MP0006082_CNS_inflammation2.65067056
14MP0003868_abnormal_feces_composition2.61047873
15MP0008875_abnormal_xenobiotic_pharmacok2.51069638
16MP0002254_reproductive_system_inflammat2.48990087
17MP0001664_abnormal_digestion2.41837176
18MP0002419_abnormal_innate_immunity2.32142982
19MP0005670_abnormal_white_adipose2.32126323
20MP0005000_abnormal_immune_tolerance2.30018849
21MP0003252_abnormal_bile_duct2.27546942
22MP0005464_abnormal_platelet_physiology2.17988879
23MP0005058_abnormal_lysosome_morphology2.17227567
24MP0005025_abnormal_response_to2.12536169
25MP0001765_abnormal_ion_homeostasis1.98859950
26MP0003183_abnormal_peptide_metabolism1.95674045
27MP0003724_increased_susceptibility_to1.94550098
28MP0004147_increased_porphyrin_level1.93348316
29MP0003303_peritoneal_inflammation1.89413485
30MP0000566_synostosis1.88721304
31MP0010329_abnormal_lipoprotein_level1.88226726
32MP0002452_abnormal_antigen_presenting1.85203983
33MP0002796_impaired_skin_barrier1.82799795
34MP0003693_abnormal_embryo_hatching1.80824482
35MP0003186_abnormal_redox_activity1.72392775
36MP0004782_abnormal_surfactant_physiolog1.71497682
37MP0010155_abnormal_intestine_physiology1.71296051
38MP0001873_stomach_inflammation1.68515024
39MP0005671_abnormal_response_to1.68415837
40MP0009764_decreased_sensitivity_to1.66617302
41MP0002723_abnormal_immune_serum1.65330083
42MP0001853_heart_inflammation1.64387469
43MP0001845_abnormal_inflammatory_respons1.61539696
44MP0001800_abnormal_humoral_immune1.58799594
45MP0004019_abnormal_vitamin_homeostasis1.58590823
46MP0008469_abnormal_protein_level1.56187924
47MP0005365_abnormal_bile_salt1.56053007
48MP0000343_altered_response_to1.53664952
49MP0003075_altered_response_to1.50265039
50MP0001533_abnormal_skeleton_physiology1.49075404
51MP0005381_digestive/alimentary_phenotyp1.48074179
52MP0001666_abnormal_nutrient_absorption1.47707705
53MP0001819_abnormal_immune_cell1.46312223
54MP0005636_abnormal_mineral_homeostasis1.45017000
55MP0002098_abnormal_vibrissa_morphology1.43454364
56MP0004510_myositis1.42108282
57MP0002420_abnormal_adaptive_immunity1.41838566
58MP0003195_calcinosis1.41772922
59MP0002138_abnormal_hepatobiliary_system1.41629584
60MP0004883_abnormal_blood_vessel1.40846880
61MP0005332_abnormal_amino_acid1.40419231
62MP0005166_decreased_susceptibility_to1.40199379
63MP0005387_immune_system_phenotype1.38647756
64MP0001790_abnormal_immune_system1.38647756
65MP0003806_abnormal_nucleotide_metabolis1.38608348
66MP0002405_respiratory_system_inflammati1.38112167
67MP0009333_abnormal_splenocyte_physiolog1.37711584
68MP0005501_abnormal_skin_physiology1.29998097
69MP0000678_abnormal_parathyroid_gland1.29573998
70MP0000609_abnormal_liver_physiology1.28762455
71MP0005174_abnormal_tail_pigmentation1.27957582
72MP0000685_abnormal_immune_system1.26330831
73MP0005164_abnormal_response_to1.25968024
74MP0004947_skin_inflammation1.25105753
75MP0000858_altered_metastatic_potential1.22092973
76MP0003690_abnormal_glial_cell1.21803911
77MP0009697_abnormal_copulation1.07629492
78MP0001663_abnormal_digestive_system1.07361971
79MP0000462_abnormal_digestive_system1.06595099
80MP0009763_increased_sensitivity_to1.06485907
81MP0003656_abnormal_erythrocyte_physiolo1.04244224
82MP0009643_abnormal_urine_homeostasis1.03333481
83MP0005451_abnormal_body_composition1.02220213
84MP0005319_abnormal_enzyme/_coenzyme1.00998875
85MP0002118_abnormal_lipid_homeostasis0.98053277
86MP0003453_abnormal_keratinocyte_physiol0.97344829
87MP0010678_abnormal_skin_adnexa0.97204398
88MP0000490_abnormal_crypts_of0.95941029
89MP0000467_abnormal_esophagus_morphology0.95839719
90MP0009780_abnormal_chondrocyte_physiolo0.94951774
91MP0002932_abnormal_joint_morphology0.93783479
92MP0005408_hypopigmentation0.93327046
93MP0002136_abnormal_kidney_physiology0.91509813
94MP0002638_abnormal_pupillary_reflex0.91113024
95MP0005584_abnormal_enzyme/coenzyme_acti0.90836882
96MP0001216_abnormal_epidermal_layer0.89998878
97MP0009379_abnormal_foot_pigmentation0.89538212
98MP0005083_abnormal_biliary_tract0.88524766
99MP0005167_abnormal_blood-brain_barrier0.87770693
100MP0002277_abnormal_respiratory_mucosa0.86898623
101MP0002006_tumorigenesis0.86895077
102MP0010352_gastrointestinal_tract_polyps0.85825782
103MP0004957_abnormal_blastocyst_morpholog0.85209883
104MP0000716_abnormal_immune_system0.84986453
105MP0000537_abnormal_urethra_morphology0.83954834
106MP0003705_abnormal_hypodermis_morpholog0.82737008
107MP0003448_altered_tumor_morphology0.82329926
108MP0002998_abnormal_bone_remodeling0.81932494
109MP0008872_abnormal_physiological_respon0.81152501
110MP0000598_abnormal_liver_morphology0.79958469
111MP0003638_abnormal_response/metabolism_0.79629810
112MP0005666_abnormal_adipose_tissue0.78911308
113MP0005310_abnormal_salivary_gland0.76700714
114MP0000249_abnormal_blood_vessel0.75833696
115MP0003828_pulmonary_edema0.75767942
116MP0008004_abnormal_stomach_pH0.75473832
117MP0010234_abnormal_vibrissa_follicle0.74954878
118MP0001764_abnormal_homeostasis0.73720863
119MP0001756_abnormal_urination0.73588961
120MP0003172_abnormal_lysosome_physiology0.73150184
121MP0002876_abnormal_thyroid_physiology0.72322942
122MP0003718_maternal_effect0.71221397
123MP0000689_abnormal_spleen_morphology0.71030541
124MP0003879_abnormal_hair_cell0.70990305
125MP0000477_abnormal_intestine_morphology0.70925111
126MP0003300_gastrointestinal_ulcer0.70861184
127MP0000604_amyloidosis0.70416111
128MP0009642_abnormal_blood_homeostasis0.69555709
129MP0003866_abnormal_defecation0.69438112
130MP0002132_abnormal_respiratory_system0.68855523
131MP0002822_catalepsy0.68517452
132MP0001485_abnormal_pinna_reflex0.68309486
133MP0005376_homeostasis/metabolism_phenot0.68098614
134MP0009765_abnormal_xenobiotic_induced0.67897497
135MP0005084_abnormal_gallbladder_morpholo0.67354191
136MP0002429_abnormal_blood_cell0.67281727
137MP0001851_eye_inflammation0.64142072
138MP0002877_abnormal_melanocyte_morpholog0.64010076
139MP0000538_abnormal_urinary_bladder0.63214182
140MP0002396_abnormal_hematopoietic_system0.63012644
141MP0005076_abnormal_cell_differentiation0.63006601
142MP0004185_abnormal_adipocyte_glucose0.61884011
143MP0003941_abnormal_skin_development0.61284570
144MP0006036_abnormal_mitochondrial_physio0.57223287
145MP0000230_abnormal_systemic_arterial0.56790180
146MP0004858_abnormal_nervous_system0.54842574
147MP0001881_abnormal_mammary_gland0.53925647
148MP0000470_abnormal_stomach_morphology0.50859965
149MP0000377_abnormal_hair_follicle0.50016261
150MP0010771_integument_phenotype0.48939243
151MP0005266_abnormal_metabolism0.48892499
152MP0005165_increased_susceptibility_to0.48507497
153MP0002249_abnormal_larynx_morphology0.48301201
154MP0001849_ear_inflammation0.47463282
155MP0003953_abnormal_hormone_level0.47440637
156MP0000627_abnormal_mammary_gland0.46935286
157MP0002971_abnormal_brown_adipose0.46845920

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)8.69823591
2Metabolic alkalosis (HP:0200114)6.11467128
3Recurrent abscess formation (HP:0002722)5.97320098
4Recurrent bacterial skin infections (HP:0005406)5.66284068
5Abnormality of renin-angiotensin system (HP:0000847)5.51026662
6Eczematoid dermatitis (HP:0000976)5.29102893
7Recurrent gram-negative bacterial infections (HP:0005420)5.06579207
8Decreased circulating renin level (HP:0003351)4.88381598
9Vacuolated lymphocytes (HP:0001922)4.60656442
10Alkalosis (HP:0001948)4.31377428
11Abnormality of chloride homeostasis (HP:0011422)4.22967937
12Hyperaldosteronism (HP:0000859)4.09959718
13Abnormality of macrophages (HP:0004311)4.06557310
14Axonal loss (HP:0003447)4.06161597
15Right ventricular cardiomyopathy (HP:0011663)3.80982519
16Ileus (HP:0002595)3.77693768
17Abdominal distention (HP:0003270)3.70241610
18Systemic lupus erythematosus (HP:0002725)3.68748241
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.65661832
20Flat acetabular roof (HP:0003180)3.61813285
21Xanthomatosis (HP:0000991)3.59508753
22Recurrent skin infections (HP:0001581)3.47126755
23Abnormality of monocarboxylic acid metabolism (HP:0010996)3.42883588
24Nausea (HP:0002018)3.41611546
25Abnormality of complement system (HP:0005339)3.40276721
26Conjugated hyperbilirubinemia (HP:0002908)3.39833938
27Mediastinal lymphadenopathy (HP:0100721)3.38540519
28Joint hemorrhage (HP:0005261)3.37036762
29Autoimmune thrombocytopenia (HP:0001973)3.34444829
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.32662656
31Decreased activity of mitochondrial respiratory chain (HP:0008972)3.32662656
32Abnormality of aromatic amino acid family metabolism (HP:0004338)3.29962968
33Stenosis of the external auditory canal (HP:0000402)3.20868308
34Obstructive lung disease (HP:0006536)3.19343154
35Chronic obstructive pulmonary disease (HP:0006510)3.19343154
36Deep venous thrombosis (HP:0002625)3.10899045
37Gingivitis (HP:0000230)3.03686748
38Hyponatremia (HP:0002902)3.01887684
39Hypobetalipoproteinemia (HP:0003563)3.01784255
40Complement deficiency (HP:0004431)2.99635408
41Glomerulonephritis (HP:0000099)2.98378039
42Orchitis (HP:0100796)2.98354458
43Myocardial infarction (HP:0001658)2.97028038
44Macrocytic anemia (HP:0001972)2.93494823
45Abnormality of the common coagulation pathway (HP:0010990)2.91693309
46Palpitations (HP:0001962)2.88798464
47Abnormality of the vitamin B12 metabolism (HP:0004341)2.83654527
48Confusion (HP:0001289)2.79680320
49Hypercholesterolemia (HP:0003124)2.79418925
50Abnormality of pyrimidine metabolism (HP:0004353)2.78516639
51Impaired platelet aggregation (HP:0003540)2.77448363
52Abnormal platelet function (HP:0011869)2.77448363
53Elevated erythrocyte sedimentation rate (HP:0003565)2.76327804
543-Methylglutaconic aciduria (HP:0003535)2.73241204
55Proximal tubulopathy (HP:0000114)2.71468409
56Pustule (HP:0200039)2.71372529
57Myositis (HP:0100614)2.70820700
58Epidermoid cyst (HP:0200040)2.70532266
59Menorrhagia (HP:0000132)2.70212354
60Hemorrhage of the eye (HP:0011885)2.69471853
61Amyloidosis (HP:0011034)2.63523804
62Focal segmental glomerulosclerosis (HP:0000097)2.63344900
63Nephritis (HP:0000123)2.61658844
64Pili torti (HP:0003777)2.61383931
65Recurrent fungal infections (HP:0002841)2.61122569
66Abnormality of vitamin B metabolism (HP:0004340)2.57473972
67Abnormality of cells of the erythroid lineage (HP:0012130)2.57223281
68Colitis (HP:0002583)2.55108260
69Intrahepatic cholestasis (HP:0001406)2.51765250
70Cellulitis (HP:0100658)2.51568028
71Hypokalemia (HP:0002900)2.51032541
72Type I transferrin isoform profile (HP:0003642)2.49277518
73Urticaria (HP:0001025)2.47830779
74Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.47442203
75Abnormality of glycolipid metabolism (HP:0010969)2.47244733
76Abnormality of liposaccharide metabolism (HP:0010968)2.47244733
77Abnormality of glycosphingolipid metabolism (HP:0004343)2.47244733
78Villous atrophy (HP:0011473)2.46522760
79Abnormality of small intestinal villus morphology (HP:0011472)2.46522760
80Abnormality of vitamin metabolism (HP:0100508)2.45979832
81Malnutrition (HP:0004395)2.44688036
82Abnormal hair laboratory examination (HP:0003328)2.44083083
83Hypolipoproteinemia (HP:0010981)2.44066464
84Hematochezia (HP:0002573)2.43452125
85Prolonged partial thromboplastin time (HP:0003645)2.42978720
86Stomatitis (HP:0010280)2.42278830
87Renal tubular acidosis (HP:0001947)2.40650118
88Meningitis (HP:0001287)2.37057616
89Abnormality of urine glucose concentration (HP:0011016)2.34924829
90Glycosuria (HP:0003076)2.34924829
91Abnormality of potassium homeostasis (HP:0011042)2.32552503
92Vasculitis (HP:0002633)2.31053951
93Prostate neoplasm (HP:0100787)2.27990788
94Petechiae (HP:0000967)2.26663649
95Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.26578934
96Spinal cord compression (HP:0002176)2.25905606
97Epistaxis (HP:0000421)2.23732061
98Dicarboxylic aciduria (HP:0003215)2.23263996
99Abnormality of dicarboxylic acid metabolism (HP:0010995)2.23263996
100Increased neuronal autofluorescent lipopigment (HP:0002074)2.20991752
101Widely patent fontanelles and sutures (HP:0004492)2.20717048
102Congenital, generalized hypertrichosis (HP:0004540)2.20218495
103Upper motor neuron abnormality (HP:0002127)2.20094665
104Abnormal vertebral ossification (HP:0100569)2.19079184
105Abnormality of fatty-acid metabolism (HP:0004359)2.18779641
106Renal tubular dysfunction (HP:0000124)2.17113998
107Hepatosplenomegaly (HP:0001433)2.16889280
108Curly hair (HP:0002212)2.15696633
109Megaloblastic anemia (HP:0001889)2.14960247
110Generalized aminoaciduria (HP:0002909)2.14791494
111Dehydration (HP:0001944)2.14494429
112Hypoalphalipoproteinemia (HP:0003233)2.14178183
113Reduced antithrombin III activity (HP:0001976)2.13458717
114Increased cerebral lipofuscin (HP:0011813)2.11876680
115Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11675488
116Abnormal platelet volume (HP:0011876)2.10496564
117Vascular calcification (HP:0004934)2.10374792
118Chronic bronchitis (HP:0004469)2.10197579
119Hyperammonemia (HP:0001987)2.10137095
120Fat malabsorption (HP:0002630)2.09931065
121Abnormality of proline metabolism (HP:0010907)2.09309040
122Hydroxyprolinuria (HP:0003080)2.09309040
123Bone cyst (HP:0012062)2.08809470
124Glomerulosclerosis (HP:0000096)2.07299108
125Dysostosis multiplex (HP:0000943)2.06682421
126Increased serum ferritin (HP:0003281)2.05246109
127Esophageal neoplasm (HP:0100751)2.04835864
128Neoplasm of head and neck (HP:0012288)2.04835864
129Metabolic acidosis (HP:0001942)2.04294409
130Cerebral palsy (HP:0100021)2.03349063
131Gingival bleeding (HP:0000225)2.02173412
132Increased mean platelet volume (HP:0011877)2.01201240
133Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.01163149
134Posterior subcapsular cataract (HP:0007787)2.01146217
135Abnormality of sodium homeostasis (HP:0010931)2.01144201
136Cheilitis (HP:0100825)2.00946651
137Osteomyelitis (HP:0002754)2.00140127
138Recurrent cutaneous fungal infections (HP:0011370)2.00100145
139Chronic mucocutaneous candidiasis (HP:0002728)2.00100145
140Abnormality of carpal bone ossification (HP:0006257)1.99328513
141Peritonitis (HP:0002586)1.98983722
142Optic neuritis (HP:0100653)1.97919073
143Retrobulbar optic neuritis (HP:0100654)1.97919073
144Woolly hair (HP:0002224)1.97535063
145Abnormal tarsal ossification (HP:0008369)1.96640548
146Abnormality of iron homeostasis (HP:0011031)1.96360011
147Neonatal short-limb short stature (HP:0008921)1.96263911
148Adrenal overactivity (HP:0002717)1.96244856
149Hyperlipoproteinemia (HP:0010980)1.96201894
150Abnormal urine phosphate concentration (HP:0012599)1.95613342
151Hoarse voice (HP:0001609)1.95232823
152Abnormality of purine metabolism (HP:0004352)1.94945564
153Purpura (HP:0000979)1.94601176
154Partial duplication of thumb phalanx (HP:0009944)1.94258853
155Chronic diarrhea (HP:0002028)1.93985882
156Basal ganglia calcification (HP:0002135)1.93980726
157Abnormality of sulfur amino acid metabolism (HP:0004339)1.93808236
158Flattened epiphyses (HP:0003071)1.93252952
159Inflammation of the large intestine (HP:0002037)1.92875727
160Micronodular cirrhosis (HP:0001413)1.92658534
161Syncope (HP:0001279)1.92201406
162Hyperparathyroidism (HP:0000843)1.91348623
163Abnormality of nucleobase metabolism (HP:0010932)1.90384743
164Hyperuricemia (HP:0002149)1.90350912
165Increased purine levels (HP:0004368)1.90350912
166Pancreatitis (HP:0001733)1.89892071
167Hypoglycemic coma (HP:0001325)1.89179440
168Disinhibition (HP:0000734)1.88373367
169Hemoptysis (HP:0002105)1.88259640
170Hyperphosphaturia (HP:0003109)1.87518922
171Increased muscle lipid content (HP:0009058)1.87292424
172Abnormality of the distal phalanx of the thumb (HP:0009617)1.86760019
173Hyperkalemia (HP:0002153)1.86113650
174Gout (HP:0001997)1.84520099
175Abnormal biliary tract morphology (HP:0012440)1.83970689
176Flat capital femoral epiphysis (HP:0003370)1.83793717
177Conjunctival hamartoma (HP:0100780)1.79431282
178Late onset (HP:0003584)1.78841473
179Pigmentary retinal degeneration (HP:0001146)1.78678285
180Congenital sensorineural hearing impairment (HP:0008527)1.77884531
181Increased intramyocellular lipid droplets (HP:0012240)1.76202062
182Abnormality of the vocal cords (HP:0008777)1.73359435

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.91769432
2LMTK24.85934996
3ERN13.71720261
4NME23.66912889
5ACVR1B3.35581365
6MAP3K143.29496059
7MET3.28180835
8MAP3K103.28030511
9TYK23.20742452
10PDK23.20157562
11ARAF3.15182572
12PIK3CA3.14595540
13PIM22.95578964
14IRAK32.86904638
15MAP4K12.50183914
16STK392.48006597
17IRAK42.45475526
18RIPK42.39989786
19NEK92.34361253
20SIK12.27127914
21BLK2.26412793
22CASK2.00332882
23CLK11.98203885
24RIPK11.95023277
25TBK11.92213539
26RPS6KB21.80056429
27IKBKB1.78727215
28STK241.75385378
29KIT1.60079360
30MAP3K111.53940193
31MYLK1.53109411
32JAK11.51405485
33MST41.48324191
34ABL21.47826876
35MATK1.45314029
36MST1R1.40014125
37PKN21.39005402
38IKBKE1.37868008
39OXSR11.34082204
40FLT31.32564688
41BRSK21.32027875
42TXK1.29383366
43TEC1.28463963
44MAP2K21.27334308
45MAP3K131.25014947
46CSK1.21666752
47CSF1R1.17593289
48PBK1.15767900
49TAOK21.14031334
50PHKG21.07676125
51PHKG11.07676125
52MOS1.07063355
53BMPR21.06737838
54RPS6KA41.05329047
55TGFBR21.01625083
56EPHB20.98249128
57JAK20.97565199
58PIM10.96097343
59PRKCI0.95451010
60IRAK10.95308838
61TESK20.93300150
62CHUK0.93227814
63MAP3K120.90536755
64PRKG20.89695515
65MAP3K20.88406134
66SYK0.88344868
67JAK30.88206453
68KSR20.87456772
69LYN0.87130261
70BTK0.86005335
71PTK20.85165680
72BMX0.84869428
73GRK60.81045741
74GRK70.80720390
75TESK10.80374369
76YES10.80271229
77HCK0.79266996
78ZAP700.79237679
79CDK90.73048015
80BRAF0.71703448
81CAMK2D0.71039274
82MAP3K10.70427935
83DDR20.70133445
84CAMK2G0.69517729
85FRK0.67892536
86GRK10.67754645
87PDPK10.67193908
88PDK10.66795005
89PTK60.66482609
90AURKB0.66082128
91CDK60.61217561
92TAOK30.60401144
93BMPR1B0.59709140
94WNK40.59371847
95MAP3K30.58198464
96ICK0.57970219
97MAP2K60.55132491
98FGR0.54967133
99EIF2AK10.54795828
100EPHB10.52796351
101MAP3K80.52061920
102CAMK2B0.50320978
103NEK10.48716989
104LCK0.48568139
105EIF2AK20.48288477
106PRKCD0.47011148
107PAK40.46226298
108NEK60.45560401
109RPS6KA60.45396268
110PRKAA20.44547332
111ERBB40.43526283
112LATS20.42565956
113RPS6KC10.42221384
114RPS6KL10.42221384
115ZAK0.41085506
116MAPKAPK30.40941678
117RAF10.40702263
118AKT20.40390917
119MAP3K70.39945905
120MAP2K10.39005091
121BCKDK0.38883835
122ABL10.38738573
123DAPK10.38733750
124MAPK70.37921188
125IRAK20.35822751
126HIPK20.35537868
127PRKCQ0.34770625
128MAP2K30.34699272
129ITK0.33534442
130MAPK40.33402311
131PRKCA0.31065856
132TTK0.27875881
133ILK0.27468637
134MAPKAPK20.26509307
135CDC70.26221966
136NLK0.25925298
137MAP3K50.25663231
138DYRK1B0.25371366
139CSNK1A10.25009233
140TAOK10.24629053
141RPS6KA20.24543083
142STK30.24361337
143MAPK120.24331215
144ERBB20.24169039
145EGFR0.23387147
146PLK10.22297307
147PRKCE0.21769961
148AURKA0.20947985
149MELK0.20679890
150SRC0.19743276
151CSNK2A20.18734682
152BRSK10.18693692
153CDK30.17520595
154VRK20.15962485
155CSNK1E0.14904176
156STK160.14882610
157SMG10.14762779
158PRKACG0.14265070
159SGK10.12864650
160SCYL20.12762138

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.97339095
2* Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.55152180
3* Pentose and glucuronate interconversions_Homo sapiens_hsa000403.17603599
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.89904443
5* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.82759897
6* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.82111633
7Staphylococcus aureus infection_Homo sapiens_hsa051502.72938802
8* Chemical carcinogenesis_Homo sapiens_hsa052042.47897190
9Leishmaniasis_Homo sapiens_hsa051402.01901373
10Glutathione metabolism_Homo sapiens_hsa004801.99024965
11Sulfur metabolism_Homo sapiens_hsa009201.93904808
12Fat digestion and absorption_Homo sapiens_hsa049751.90581808
13Complement and coagulation cascades_Homo sapiens_hsa046101.85337989
14* Starch and sucrose metabolism_Homo sapiens_hsa005001.79483168
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.76484262
16Nitrogen metabolism_Homo sapiens_hsa009101.75778252
17Arginine biosynthesis_Homo sapiens_hsa002201.74138916
18* Steroid hormone biosynthesis_Homo sapiens_hsa001401.71329844
19* Drug metabolism - other enzymes_Homo sapiens_hsa009831.67709745
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.56409415
21Lysosome_Homo sapiens_hsa041421.51104084
22Pentose phosphate pathway_Homo sapiens_hsa000301.49689740
23Folate biosynthesis_Homo sapiens_hsa007901.42424554
24PPAR signaling pathway_Homo sapiens_hsa033201.40976794
25Histidine metabolism_Homo sapiens_hsa003401.38789904
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38639371
27Other glycan degradation_Homo sapiens_hsa005111.36782903
28* Retinol metabolism_Homo sapiens_hsa008301.36565576
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36393720
30Tuberculosis_Homo sapiens_hsa051521.33710423
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.31988576
32Legionellosis_Homo sapiens_hsa051341.30783815
33Pertussis_Homo sapiens_hsa051331.30197578
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29253610
35Mineral absorption_Homo sapiens_hsa049781.29221426
36Osteoclast differentiation_Homo sapiens_hsa043801.28891957
37Tryptophan metabolism_Homo sapiens_hsa003801.27632642
38Sulfur relay system_Homo sapiens_hsa041221.25171432
39* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22579819
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.22478893
41Peroxisome_Homo sapiens_hsa041461.19739057
42Fatty acid degradation_Homo sapiens_hsa000711.17513522
43Renin-angiotensin system_Homo sapiens_hsa046141.16428973
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13893049
45Ribosome_Homo sapiens_hsa030101.11774991
46Caffeine metabolism_Homo sapiens_hsa002321.10847680
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.08361222
48NF-kappa B signaling pathway_Homo sapiens_hsa040641.06116042
49Fructose and mannose metabolism_Homo sapiens_hsa000511.05204976
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03013911
51Rheumatoid arthritis_Homo sapiens_hsa053231.02447606
52Salmonella infection_Homo sapiens_hsa051320.98315766
53Butanoate metabolism_Homo sapiens_hsa006500.98185445
54Phagosome_Homo sapiens_hsa041450.97364311
55Tyrosine metabolism_Homo sapiens_hsa003500.95156540
56Graft-versus-host disease_Homo sapiens_hsa053320.93616773
57Vitamin digestion and absorption_Homo sapiens_hsa049770.91275631
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90845730
59beta-Alanine metabolism_Homo sapiens_hsa004100.89633934
60Fatty acid elongation_Homo sapiens_hsa000620.89622467
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.88150695
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86899466
63Proteasome_Homo sapiens_hsa030500.82126795
64Bile secretion_Homo sapiens_hsa049760.82079200
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79717672
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79712289
67Arachidonic acid metabolism_Homo sapiens_hsa005900.77520212
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77427333
69Apoptosis_Homo sapiens_hsa042100.77173175
70Mismatch repair_Homo sapiens_hsa034300.76549447
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75983412
72Alzheimers disease_Homo sapiens_hsa050100.75781006
73Phenylalanine metabolism_Homo sapiens_hsa003600.74393377
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73578442
75Parkinsons disease_Homo sapiens_hsa050120.71046125
76Pancreatic secretion_Homo sapiens_hsa049720.70339415
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70296358
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68919630
79Protein export_Homo sapiens_hsa030600.68747240
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67649689
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.67269371
82Toxoplasmosis_Homo sapiens_hsa051450.66881964
83Ether lipid metabolism_Homo sapiens_hsa005650.66481685
84Steroid biosynthesis_Homo sapiens_hsa001000.65216896
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64410533
86TNF signaling pathway_Homo sapiens_hsa046680.62984373
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61520226
88Carbon metabolism_Homo sapiens_hsa012000.58920198
89Hematopoietic cell lineage_Homo sapiens_hsa046400.58264540
90Galactose metabolism_Homo sapiens_hsa000520.56867361
91B cell receptor signaling pathway_Homo sapiens_hsa046620.56693530
92Pyruvate metabolism_Homo sapiens_hsa006200.55654761
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55582092
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54886395
95Malaria_Homo sapiens_hsa051440.54212679
96Fatty acid metabolism_Homo sapiens_hsa012120.53957291
97Linoleic acid metabolism_Homo sapiens_hsa005910.53890815
98Nucleotide excision repair_Homo sapiens_hsa034200.53318791
99Oxidative phosphorylation_Homo sapiens_hsa001900.53038993
100Huntingtons disease_Homo sapiens_hsa050160.52334913
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52230265
102ABC transporters_Homo sapiens_hsa020100.51762443
103Arginine and proline metabolism_Homo sapiens_hsa003300.51440746
104African trypanosomiasis_Homo sapiens_hsa051430.51370791
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50459640
106* Metabolic pathways_Homo sapiens_hsa011000.50224388
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.49505644
108Protein digestion and absorption_Homo sapiens_hsa049740.48872397
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48307544
110Influenza A_Homo sapiens_hsa051640.47530250
111Tight junction_Homo sapiens_hsa045300.45424786
112Vitamin B6 metabolism_Homo sapiens_hsa007500.44915401
113Hepatitis C_Homo sapiens_hsa051600.43908877
114Chemokine signaling pathway_Homo sapiens_hsa040620.43229133
115Sphingolipid metabolism_Homo sapiens_hsa006000.42822184
116Glycerolipid metabolism_Homo sapiens_hsa005610.42366167
117Selenocompound metabolism_Homo sapiens_hsa004500.41805693
118Allograft rejection_Homo sapiens_hsa053300.40905407
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40634498
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39929246
121DNA replication_Homo sapiens_hsa030300.39914725
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38756620
1232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37726925
124Vibrio cholerae infection_Homo sapiens_hsa051100.34087181
125Propanoate metabolism_Homo sapiens_hsa006400.29101892
126N-Glycan biosynthesis_Homo sapiens_hsa005100.25477291
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.24327501
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21483867
129Base excision repair_Homo sapiens_hsa034100.21455602
130Biosynthesis of amino acids_Homo sapiens_hsa012300.19330765
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.18833421
132Cardiac muscle contraction_Homo sapiens_hsa042600.17614782
133Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.14929218
134Fatty acid biosynthesis_Homo sapiens_hsa000610.14461289
135Renin secretion_Homo sapiens_hsa049240.10605585
136Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09302475
137Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.06709147
138Homologous recombination_Homo sapiens_hsa034400.03640727
139Pyrimidine metabolism_Homo sapiens_hsa002400.03339653

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