UGT1A6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)9.95518140
2daunorubicin metabolic process (GO:0044597)9.95518140
3polyketide metabolic process (GO:0030638)9.95518140
4aminoglycoside antibiotic metabolic process (GO:0030647)8.90194580
5* cellular glucuronidation (GO:0052695)8.15311779
6* glucuronate metabolic process (GO:0019585)7.64614235
7* uronic acid metabolic process (GO:0006063)7.64614235
8exogenous drug catabolic process (GO:0042738)7.41922671
9negative regulation of fibrinolysis (GO:0051918)7.04716128
10drug catabolic process (GO:0042737)6.77069724
11regulation of fibrinolysis (GO:0051917)6.68135512
12epoxygenase P450 pathway (GO:0019373)6.68086585
13L-phenylalanine catabolic process (GO:0006559)6.64450092
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.64450092
15L-phenylalanine metabolic process (GO:0006558)6.54056472
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.54056472
17regulation of protein activation cascade (GO:2000257)6.39994093
18urea metabolic process (GO:0019627)6.34360558
19complement activation, alternative pathway (GO:0006957)6.19445612
20omega-hydroxylase P450 pathway (GO:0097267)6.10978724
21glyoxylate metabolic process (GO:0046487)6.04464167
22regulation of complement activation (GO:0030449)5.95429791
23flavonoid metabolic process (GO:0009812)5.90391190
24nitrogen cycle metabolic process (GO:0071941)5.71556890
25fibrinolysis (GO:0042730)5.67387243
26primary alcohol catabolic process (GO:0034310)5.44225177
27urea cycle (GO:0000050)5.41627926
28drug metabolic process (GO:0017144)5.25437730
29phenylpropanoid metabolic process (GO:0009698)5.05463892
30glycoside metabolic process (GO:0016137)5.00526209
31bile acid and bile salt transport (GO:0015721)4.93296067
32bile acid metabolic process (GO:0008206)4.90915731
33protein carboxylation (GO:0018214)4.83621080
34peptidyl-glutamic acid carboxylation (GO:0017187)4.83621080
35intestinal cholesterol absorption (GO:0030299)4.81183439
36ethanol oxidation (GO:0006069)4.80272788
37bile acid biosynthetic process (GO:0006699)4.72560938
38negative regulation of cholesterol transport (GO:0032375)4.67603394
39negative regulation of sterol transport (GO:0032372)4.67603394
40aromatic amino acid family catabolic process (GO:0009074)4.60442412
41drug transmembrane transport (GO:0006855)4.58561783
42blood coagulation, intrinsic pathway (GO:0007597)4.53050686
43amino-acid betaine metabolic process (GO:0006577)4.42249535
44retinal metabolic process (GO:0042574)4.29209878
45positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.28019588
46hormone catabolic process (GO:0042447)4.27215871
47negative regulation of hemostasis (GO:1900047)4.26192317
48negative regulation of blood coagulation (GO:0030195)4.26192317
49xenobiotic catabolic process (GO:0042178)4.15471771
50serine family amino acid catabolic process (GO:0009071)4.12249137
51regulation of plasminogen activation (GO:0010755)4.07104217
52negative regulation of lipase activity (GO:0060192)4.06651257
53oxidative demethylation (GO:0070989)4.04884056
54glycine metabolic process (GO:0006544)4.01932926
55ethanol metabolic process (GO:0006067)4.00501694
56negative regulation of coagulation (GO:0050819)3.92694657
57protein activation cascade (GO:0072376)3.91984228
58quinone metabolic process (GO:1901661)3.90900587
59negative regulation of wound healing (GO:0061045)3.90027493
60progesterone metabolic process (GO:0042448)3.85901524
61drug transport (GO:0015893)3.82598083
62phospholipid efflux (GO:0033700)3.77313412
63negative regulation of protein activation cascade (GO:2000258)3.75543567
64cysteine metabolic process (GO:0006534)3.69814409
65complement activation, classical pathway (GO:0006958)3.66398944
66acute-phase response (GO:0006953)3.66138197
67regulation of humoral immune response (GO:0002920)3.64912157
68complement activation (GO:0006956)3.62692425
69response to mercury ion (GO:0046689)3.62465194
70S-adenosylmethionine metabolic process (GO:0046500)3.61119985
71positive regulation of hemostasis (GO:1900048)3.57513691
72positive regulation of blood coagulation (GO:0030194)3.57513691
73regulation of triglyceride catabolic process (GO:0010896)3.54376770
74heme transport (GO:0015886)3.53097160
75acylglycerol homeostasis (GO:0055090)3.50963801
76triglyceride homeostasis (GO:0070328)3.50963801
77phosphate ion transmembrane transport (GO:0035435)3.49879054
78serine family amino acid metabolic process (GO:0009069)3.49440505
79* xenobiotic metabolic process (GO:0006805)3.47574218
80tyrosine metabolic process (GO:0006570)3.45717969
81coenzyme catabolic process (GO:0009109)3.44011578
82cellular aldehyde metabolic process (GO:0006081)3.42641723
83arginine metabolic process (GO:0006525)3.40897429
84C21-steroid hormone metabolic process (GO:0008207)3.34920109
85retinoic acid metabolic process (GO:0042573)3.34202726
86negative regulation of fatty acid biosynthetic process (GO:0045717)3.33979539
87regulation of cholesterol esterification (GO:0010872)3.33478464
88positive regulation of coagulation (GO:0050820)3.32257977
89citrulline biosynthetic process (GO:0019240)3.31803907
90cofactor catabolic process (GO:0051187)3.29060120
91fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.26844079
92very-low-density lipoprotein particle assembly (GO:0034379)3.25476060
93primary alcohol metabolic process (GO:0034308)3.25015350
94glutamate metabolic process (GO:0006536)3.22552672
95response to nitrosative stress (GO:0051409)3.21890829
96urate metabolic process (GO:0046415)3.18784840
97negative regulation of fatty acid metabolic process (GO:0045922)3.13761950
98triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.13412233
99regulation of apoptotic cell clearance (GO:2000425)3.13380943
100high-density lipoprotein particle remodeling (GO:0034375)3.12574548

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.40747745
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.48745898
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.74653701
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.60261185
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.39650059
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.37206950
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.91671697
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.77269891
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.64876090
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.53648360
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.18198807
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.84615542
13* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.60234290
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.48881643
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.36799474
16ESR1_20079471_ChIP-ChIP_T-47D_Human2.26660825
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.23228225
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.21000770
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.09946033
20ESR1_15608294_ChIP-ChIP_MCF-7_Human2.04374732
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.97561945
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.96981648
23CDX2_20551321_ChIP-Seq_CACO-2_Human1.88597367
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.85581797
25FOXA2_19822575_ChIP-Seq_HepG2_Human1.85129250
26TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.84389916
27SOX2_27498859_Chip-Seq_STOMACH_Mouse1.78893781
28PPAR_26484153_Chip-Seq_NCI-H1993_Human1.77364155
29HIF1A_21447827_ChIP-Seq_MCF-7_Human1.75849486
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72120626
31GATA6_25053715_ChIP-Seq_YYC3_Human1.69197900
32HNF4A_19822575_ChIP-Seq_HepG2_Human1.66471672
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.58033172
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57929074
35* SOX2_20726797_ChIP-Seq_SW620_Human1.50416082
36* RACK7_27058665_Chip-Seq_MCF-7_Human1.47812426
37* GATA4_25053715_ChIP-Seq_YYC3_Human1.47275403
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46522303
39* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46250514
40* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.44378927
41* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.44378927
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39829397
43CLOCK_20551151_ChIP-Seq_293T_Human1.39633503
44KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38630807
45* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33117292
46PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.28505299
47ZNF263_19887448_ChIP-Seq_K562_Human1.28155589
48LXR_22292898_ChIP-Seq_THP-1_Human1.26206308
49ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22605820
50* GATA3_24758297_ChIP-Seq_MCF-7_Human1.22523098
51FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19011327
52AR_21909140_ChIP-Seq_LNCAP_Human1.17092982
53ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16290090
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13353855
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09459577
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.09370333
57FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08208169
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06726316
59ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02533718
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02302926
61AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01878807
62RUNX1_27514584_Chip-Seq_MCF-7_Human0.99890187
63SMC4_20622854_ChIP-Seq_HELA_Human0.96930877
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96634520
65RXRA_24833708_ChIP-Seq_LIVER_Mouse0.95149896
66AHR_22903824_ChIP-Seq_MCF-7_Human0.90739026
67FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.90493475
68SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89895606
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89181936
70ATF3_27146783_Chip-Seq_COLON_Human0.88505614
71SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88397532
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82397085
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.79148814
74SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78842153
75FOXA1_25552417_ChIP-Seq_VCAP_Human0.78110178
76ELK3_25401928_ChIP-Seq_HUVEC_Human0.77120585
77TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.75255754
78SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74137929
79CJUN_26792858_Chip-Seq_BT549_Human0.73714431
80KLF5_25053715_ChIP-Seq_YYC3_Human0.73280493
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71804146
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.70765722
83P300_27058665_Chip-Seq_ZR-75-30cells_Human0.70324755
84ERG_21242973_ChIP-ChIP_JURKAT_Human0.69707001
85GATA2_21666600_ChIP-Seq_HMVEC_Human0.68996008
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.68942061
87RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.68527782
88TP53_18474530_ChIP-ChIP_U2OS_Human0.68127277
89PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.67441851
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.64119482
91ARNT_22903824_ChIP-Seq_MCF-7_Human0.64048144
92STAT3_1855785_ChIP-Seq_MESCs_Mouse0.63172458
93BP1_19119308_ChIP-ChIP_Hs578T_Human0.63040515
94* TP63_22573176_ChIP-Seq_HFKS_Human0.61726369
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.61617499
96CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.60898271
97RARA_24833708_ChIP-Seq_LIVER_Mouse0.59017120
98CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.58597541
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58281313
100TBX20_22328084_ChIP-Seq_HEART_Mouse0.57960625

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.87114647
2MP0005365_abnormal_bile_salt5.65459511
3MP0008875_abnormal_xenobiotic_pharmacok5.61819698
4MP0005085_abnormal_gallbladder_physiolo5.49019719
5MP0005360_urolithiasis5.21586274
6MP0002138_abnormal_hepatobiliary_system4.39345379
7MP0003252_abnormal_bile_duct4.21104123
8MP0003195_calcinosis3.26810104
9MP0003868_abnormal_feces_composition3.17760460
10MP0001666_abnormal_nutrient_absorption3.08483281
11MP0003806_abnormal_nucleotide_metabolis2.74196613
12MP0005332_abnormal_amino_acid2.43984219
13MP0003191_abnormal_cellular_cholesterol2.18042608
14MP0009840_abnormal_foam_cell2.16523034
15MP0010329_abnormal_lipoprotein_level2.15205781
16MP0009697_abnormal_copulation2.00870044
17MP0009053_abnormal_anal_canal1.90965663
18MP0000609_abnormal_liver_physiology1.71558655
19MP0004019_abnormal_vitamin_homeostasis1.71530462
20MP0010234_abnormal_vibrissa_follicle1.64076749
21MP0005451_abnormal_body_composition1.60439493
22MP0003705_abnormal_hypodermis_morpholog1.44190053
23MP0002118_abnormal_lipid_homeostasis1.43880887
24MP0005408_hypopigmentation1.40104866
25MP0009643_abnormal_urine_homeostasis1.33496529
26MP0005023_abnormal_wound_healing1.27571136
27MP0005319_abnormal_enzyme/_coenzyme1.20862627
28MP0001661_extended_life_span1.20068377
29MP0005584_abnormal_enzyme/coenzyme_acti1.14094215
30MP0010386_abnormal_urinary_bladder1.10950538
31MP0003186_abnormal_redox_activity1.10192233
32MP0002796_impaired_skin_barrier1.10012602
33MP0002876_abnormal_thyroid_physiology1.06538431
34MP0001764_abnormal_homeostasis1.05177528
35MP0000467_abnormal_esophagus_morphology1.04993010
36MP0003566_abnormal_cell_adhesion1.02419080
37MP0003656_abnormal_erythrocyte_physiolo0.96368986
38MP0003453_abnormal_keratinocyte_physiol0.95822383
39MP0003879_abnormal_hair_cell0.94438024
40MP0010368_abnormal_lymphatic_system0.91226458
41MP0000598_abnormal_liver_morphology0.90878907
42MP0001756_abnormal_urination0.90226864
43MP0003638_abnormal_response/metabolism_0.89792229
44MP0005058_abnormal_lysosome_morphology0.89451659
45MP0004782_abnormal_surfactant_physiolog0.87756463
46MP0001348_abnormal_lacrimal_gland0.86081975
47MP0000566_synostosis0.85414587
48MP0005670_abnormal_white_adipose0.76599014
49MP0004272_abnormal_basement_membrane0.74792340
50MP0009642_abnormal_blood_homeostasis0.74588117
51MP0002136_abnormal_kidney_physiology0.72088524
52MP0002098_abnormal_vibrissa_morphology0.71790662
53MP0005501_abnormal_skin_physiology0.71190127
54MP0001915_intracranial_hemorrhage0.70861411
55MP0001851_eye_inflammation0.70169845
56MP0005376_homeostasis/metabolism_phenot0.69322527
57MP0010678_abnormal_skin_adnexa0.69066010
58MP0004264_abnormal_extraembryonic_tissu0.68908157
59MP0005636_abnormal_mineral_homeostasis0.68906718
60MP0002249_abnormal_larynx_morphology0.68412470
61MP0008469_abnormal_protein_level0.66728236
62MP0003941_abnormal_skin_development0.64515693
63MP0005164_abnormal_response_to0.62251969
64MP0009763_increased_sensitivity_to0.61108021
65MP0002060_abnormal_skin_morphology0.59434581
66MP0003690_abnormal_glial_cell0.59423754
67MP0002909_abnormal_adrenal_gland0.59138055
68MP0005187_abnormal_penis_morphology0.58540161
69MP0003878_abnormal_ear_physiology0.57460493
70MP0005377_hearing/vestibular/ear_phenot0.57460493
71MP0000003_abnormal_adipose_tissue0.57024536
72MP0000604_amyloidosis0.56469772
73MP0005076_abnormal_cell_differentiation0.56422378
74MP0005464_abnormal_platelet_physiology0.56310764
75MP0005395_other_phenotype0.56148911
76MP0002168_other_aberrant_phenotype0.55569698
77MP0000858_altered_metastatic_potential0.55046162
78MP0001216_abnormal_epidermal_layer0.54765255
79MP0000579_abnormal_nail_morphology0.54203024
80MP0002971_abnormal_brown_adipose0.53785312
81MP0005197_abnormal_uvea_morphology0.53263778
82MP0002132_abnormal_respiratory_system0.52150506
83MP0003011_delayed_dark_adaptation0.51955101
84MP0000627_abnormal_mammary_gland0.51663399
85MP0000516_abnormal_urinary_system0.50941575
86MP0005367_renal/urinary_system_phenotyp0.50941575
87MP0009780_abnormal_chondrocyte_physiolo0.50724493
88MP0002928_abnormal_bile_duct0.49561210
89MP0008874_decreased_physiological_sensi0.47590978
90MP0003183_abnormal_peptide_metabolism0.47239540
91MP0000534_abnormal_ureter_morphology0.46700607
92MP0005248_abnormal_Harderian_gland0.45169941
93MP0005257_abnormal_intraocular_pressure0.44931940
94MP0001881_abnormal_mammary_gland0.43493078
95MP0005409_darkened_coat_color0.42958944
96MP0002697_abnormal_eye_size0.42819856
97MP0004233_abnormal_muscle_weight0.42763942
98MP0001849_ear_inflammation0.39612958
99MP0000249_abnormal_blood_vessel0.39525499
100MP0005083_abnormal_biliary_tract0.38811385

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)9.69822034
2Deep venous thrombosis (HP:0002625)8.20533469
3Complement deficiency (HP:0004431)7.64783226
4Abnormality of aromatic amino acid family metabolism (HP:0004338)7.02452575
5Hypobetalipoproteinemia (HP:0003563)6.94893842
6Conjugated hyperbilirubinemia (HP:0002908)6.93852806
7Prolonged partial thromboplastin time (HP:0003645)6.69204661
8Abnormality of complement system (HP:0005339)6.48828433
9Abnormality of the common coagulation pathway (HP:0010990)5.41995279
10Intrahepatic cholestasis (HP:0001406)5.14531665
11Systemic lupus erythematosus (HP:0002725)5.11349894
12Glomerulonephritis (HP:0000099)5.06283725
13Abnormality of glutamine family amino acid metabolism (HP:0010902)4.22376733
14Joint hemorrhage (HP:0005261)4.18467917
15Spontaneous abortion (HP:0005268)4.13738107
16Hypolipoproteinemia (HP:0010981)4.10358057
17Abnormality of pyrimidine metabolism (HP:0004353)4.09692310
18Fat malabsorption (HP:0002630)4.08277256
19Nephritis (HP:0000123)4.02608151
20Xanthomatosis (HP:0000991)3.84519895
21Rickets (HP:0002748)3.58012221
22Vascular calcification (HP:0004934)3.45429922
23Steatorrhea (HP:0002570)3.42015739
24Hyperlipoproteinemia (HP:0010980)3.38811763
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.30244845
26Mitral stenosis (HP:0001718)3.16574626
27Abnormality of the intrinsic pathway (HP:0010989)3.13369045
28Hyperammonemia (HP:0001987)3.10286767
29Generalized aminoaciduria (HP:0002909)3.05812477
30Hypercholesterolemia (HP:0003124)3.04856050
31Cardiovascular calcification (HP:0011915)3.01659012
32Hemorrhage of the eye (HP:0011885)2.98554954
33Focal segmental glomerulosclerosis (HP:0000097)2.93291397
34Hyperbilirubinemia (HP:0002904)2.83296281
35Recurrent gram-negative bacterial infections (HP:0005420)2.81393696
36Osteomalacia (HP:0002749)2.76079211
37Gingival bleeding (HP:0000225)2.75843650
38Abnormality of nucleobase metabolism (HP:0010932)2.69641552
39Abnormality of the Achilles tendon (HP:0005109)2.66091687
40Abnormality of methionine metabolism (HP:0010901)2.60609500
41Hepatocellular carcinoma (HP:0001402)2.58341787
42Glomerulosclerosis (HP:0000096)2.58004636
43Abnormality of proline metabolism (HP:0010907)2.39413593
44Hydroxyprolinuria (HP:0003080)2.39413593
45Gout (HP:0001997)2.37233172
46Abnormal gallbladder physiology (HP:0012438)2.36120014
47Cholecystitis (HP:0001082)2.36120014
48Hypoalphalipoproteinemia (HP:0003233)2.31564111
49Facial shape deformation (HP:0011334)2.27279338
50Potter facies (HP:0002009)2.27279338
51Purpura (HP:0000979)2.26432591
52Abnormality of vitamin metabolism (HP:0100508)2.25452895
53Increased serum ferritin (HP:0003281)2.24173280
54Hyperglycinuria (HP:0003108)2.23985240
55Cerebral palsy (HP:0100021)2.16136527
56Abnormality of aspartate family amino acid metabolism (HP:0010899)2.14815698
57Bifid scrotum (HP:0000048)2.13941775
58Cholelithiasis (HP:0001081)2.13660713
59Abnormality of glycine metabolism (HP:0010895)2.11361266
60Abnormality of serine family amino acid metabolism (HP:0010894)2.11361266
61Back pain (HP:0003418)2.11276586
62Elevated alkaline phosphatase (HP:0003155)2.10540882
63Hyperglycinemia (HP:0002154)2.10007708
64Reduced antithrombin III activity (HP:0001976)2.07617324
65Abnormal enzyme/coenzyme activity (HP:0012379)2.05667368
66Abnormality of purine metabolism (HP:0004352)2.05451622
67Menorrhagia (HP:0000132)2.04165633
68Abnormality of alkaline phosphatase activity (HP:0004379)2.02150828
69Joint swelling (HP:0001386)1.99208506
70Increased mean platelet volume (HP:0011877)1.99102755
71Reticulocytosis (HP:0001923)1.98237778
72Nuclear cataract (HP:0100018)1.96637265
73Abnormal gallbladder morphology (HP:0012437)1.96265856
74Abnormality of iron homeostasis (HP:0011031)1.95821876
75Thrombophlebitis (HP:0004418)1.92446307
76Hyperphosphaturia (HP:0003109)1.91957054
77Abnormality of urine glucose concentration (HP:0011016)1.91639151
78Glycosuria (HP:0003076)1.91639151
79Delayed CNS myelination (HP:0002188)1.91415659
80Abnormality of serum amino acid levels (HP:0003112)1.84708490
81Abnormality of sulfur amino acid metabolism (HP:0004339)1.77899360
82Epidermoid cyst (HP:0200040)1.77862856
83Esophageal varix (HP:0002040)1.77201934
84Abnormal urine phosphate concentration (HP:0012599)1.74469507
85Abnormality of transition element cation homeostasis (HP:0011030)1.73740478
86Abdominal distention (HP:0003270)1.73463648
87Hypophosphatemic rickets (HP:0004912)1.73183375
88Metabolic acidosis (HP:0001942)1.70935626
89Abnormality of the gastric mucosa (HP:0004295)1.70106301
90Sex reversal (HP:0012245)1.69798355
91Abnormal sex determination (HP:0012244)1.69798355
92Abnormal platelet volume (HP:0011876)1.69523111
93Irritability (HP:0000737)1.69031847
94Myocardial infarction (HP:0001658)1.68931169
95Increased purine levels (HP:0004368)1.66675163
96Hyperuricemia (HP:0002149)1.66675163
97Abnormality of fatty-acid metabolism (HP:0004359)1.66335423
98Polygenic inheritance (HP:0010982)1.65005326
99Abnormal hair laboratory examination (HP:0003328)1.63429132
100Periodontitis (HP:0000704)1.62614527

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.24326500
2IRAK34.59502600
3EPHA24.51818291
4MET3.29702890
5ERN12.75628440
6MAP3K22.64441095
7ERBB42.53482137
8SIK12.45900898
9SMG12.44095599
10RIPK12.31564071
11TRIB32.27280388
12MAP3K32.26239652
13MAP3K122.11745771
14STK381.80918246
15FGFR41.79260906
16SCYL21.74206949
17PTK21.67107081
18RPS6KB21.67080620
19PAK41.66471471
20PBK1.66029151
21MAP3K91.63554547
22MAP2K61.63382913
23LATS11.55046357
24LATS21.44339363
25MAPKAPK31.40487649
26EIF2AK11.27919733
27ICK1.27134884
28TESK11.24957014
29PDGFRA1.23794076
30EPHB11.23762025
31ARAF1.22496818
32TBK11.11117303
33NTRK11.10418717
34PTK61.01539765
35NEK10.99899645
36PIK3CA0.96507862
37IRAK20.95168696
38MYLK0.91054324
39NME20.83548955
40CAMK2G0.81907402
41MAPK110.81811390
42CDK80.81214594
43FER0.78697844
44CDK90.78548282
45NEK90.76839670
46TTN0.76581700
47PDPK10.74688717
48PKN20.73329840
49IRAK10.72765031
50STK38L0.71409487
51PRKAA20.70852254
52MAP3K60.70776178
53MAP3K10.70482520
54PIK3CG0.69936089
55KSR20.68289052
56MAP3K130.64862676
57NEK60.64040202
58CDK120.63165543
59MAP2K20.61424163
60MTOR0.60516853
61BRSK20.59874870
62ABL20.58735632
63MAP2K10.58317846
64TYK20.55823908
65FGFR30.55727282
66CAMK2B0.55375680
67MST40.52870007
68PRKCI0.52785127
69TRPM70.52745328
70IGF1R0.52416354
71LRRK20.49227630
72PRKG20.47433203
73CDK60.46865452
74IRAK40.46432206
75EPHA30.45794219
76MAP3K80.44881054
77MAP2K40.44542780
78CSF1R0.43159412
79FLT30.41898097
80MELK0.38112544
81PRKACG0.37887442
82MAPK150.37825483
83MAP3K70.37655781
84PRKCZ0.34255922
85BCKDK0.33865279
86DAPK10.33701799
87ERBB20.33506730
88CDK70.30150894
89ZAP700.30084023
90CAMK2D0.28030478
91JAK10.27859016
92RET0.27055136
93BMX0.26463365
94MUSK0.26028029
95CDK40.25284944
96SRC0.24176953
97YES10.23857062
98LMTK20.22795807
99SGK30.22379719
100GSK3A0.22201001

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ascorbate and aldarate metabolism_Homo sapiens_hsa000534.44983824
2* Pentose and glucuronate interconversions_Homo sapiens_hsa000403.79716346
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.46649641
4* Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.46593227
5Caffeine metabolism_Homo sapiens_hsa002323.35577574
6* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.34508278
7* Steroid hormone biosynthesis_Homo sapiens_hsa001403.26145097
8* Retinol metabolism_Homo sapiens_hsa008303.23666060
9Complement and coagulation cascades_Homo sapiens_hsa046103.21848121
10Primary bile acid biosynthesis_Homo sapiens_hsa001203.19780020
11* Chemical carcinogenesis_Homo sapiens_hsa052043.17646208
12* Drug metabolism - other enzymes_Homo sapiens_hsa009833.10308489
13Phenylalanine metabolism_Homo sapiens_hsa003602.48838003
14* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.23987579
15Arginine biosynthesis_Homo sapiens_hsa002202.21070686
16Tyrosine metabolism_Homo sapiens_hsa003502.04707198
17Fatty acid degradation_Homo sapiens_hsa000712.04259733
18Histidine metabolism_Homo sapiens_hsa003402.03698471
19* Starch and sucrose metabolism_Homo sapiens_hsa005002.02544193
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.98354849
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.96573227
22Bile secretion_Homo sapiens_hsa049761.83810439
23Butanoate metabolism_Homo sapiens_hsa006501.83425676
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.75147623
25Tryptophan metabolism_Homo sapiens_hsa003801.74445436
26Vitamin B6 metabolism_Homo sapiens_hsa007501.43697033
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38566053
28beta-Alanine metabolism_Homo sapiens_hsa004101.38558365
29Linoleic acid metabolism_Homo sapiens_hsa005911.35032993
30PPAR signaling pathway_Homo sapiens_hsa033201.20035723
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19491332
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.18412545
33Biosynthesis of amino acids_Homo sapiens_hsa012301.16737371
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07465052
35Carbon metabolism_Homo sapiens_hsa012001.07267684
36Arachidonic acid metabolism_Homo sapiens_hsa005901.06364546
37Peroxisome_Homo sapiens_hsa041461.05200414
38Arginine and proline metabolism_Homo sapiens_hsa003300.99864628
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99335061
40Fructose and mannose metabolism_Homo sapiens_hsa000510.98722931
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96004729
42Pyruvate metabolism_Homo sapiens_hsa006200.93520170
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89876516
44Pentose phosphate pathway_Homo sapiens_hsa000300.86041017
45Staphylococcus aureus infection_Homo sapiens_hsa051500.85357841
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84175475
47Fatty acid metabolism_Homo sapiens_hsa012120.82307358
48Galactose metabolism_Homo sapiens_hsa000520.81019277
49ABC transporters_Homo sapiens_hsa020100.77692426
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76589564
51Glutathione metabolism_Homo sapiens_hsa004800.75848962
52Prion diseases_Homo sapiens_hsa050200.74249667
53Fat digestion and absorption_Homo sapiens_hsa049750.72904828
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72332869
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70079496
56Propanoate metabolism_Homo sapiens_hsa006400.67947524
57One carbon pool by folate_Homo sapiens_hsa006700.59692696
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59376914
59Lysine degradation_Homo sapiens_hsa003100.53643477
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47070951
61* Metabolic pathways_Homo sapiens_hsa011000.41012502
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.38609140
63Glycerolipid metabolism_Homo sapiens_hsa005610.38101481
64Sulfur metabolism_Homo sapiens_hsa009200.33235233
65Folate biosynthesis_Homo sapiens_hsa007900.28495749
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.27663707
67Sulfur relay system_Homo sapiens_hsa041220.22431647
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21800793
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21474304
70Fatty acid biosynthesis_Homo sapiens_hsa000610.17974621
71Fatty acid elongation_Homo sapiens_hsa000620.17717770
72Other glycan degradation_Homo sapiens_hsa005110.16028561
73Selenocompound metabolism_Homo sapiens_hsa004500.15936921
74Pertussis_Homo sapiens_hsa051330.15928648
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.11711688
76Vitamin digestion and absorption_Homo sapiens_hsa049770.10943107
77Insulin resistance_Homo sapiens_hsa049310.09696061
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.09144873
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08781092
80Sphingolipid metabolism_Homo sapiens_hsa006000.08308741
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.06798442
82Thyroid cancer_Homo sapiens_hsa052160.06445272
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.04531863
84Ovarian steroidogenesis_Homo sapiens_hsa049130.03430875
85Renin-angiotensin system_Homo sapiens_hsa046140.02468609
86N-Glycan biosynthesis_Homo sapiens_hsa005100.00710377
87ECM-receptor interaction_Homo sapiens_hsa045120.00149533
88Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1407453
89Hepatitis C_Homo sapiens_hsa05160-0.1288016
90Renal cell carcinoma_Homo sapiens_hsa05211-0.1269910
91Nitrogen metabolism_Homo sapiens_hsa00910-0.1165000
92Insulin signaling pathway_Homo sapiens_hsa04910-0.1156346
93Ether lipid metabolism_Homo sapiens_hsa00565-0.1156050
94Small cell lung cancer_Homo sapiens_hsa05222-0.1144300
95Bladder cancer_Homo sapiens_hsa05219-0.0740331
96AMPK signaling pathway_Homo sapiens_hsa04152-0.0399731
97Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0263984
98Amoebiasis_Homo sapiens_hsa05146-0.0238234
99Glucagon signaling pathway_Homo sapiens_hsa04922-0.0213111
100Steroid biosynthesis_Homo sapiens_hsa00100-0.0205885

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