UGT1A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1omega-hydroxylase P450 pathway (GO:0097267)7.87694470
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.51611539
3L-phenylalanine catabolic process (GO:0006559)7.51611539
4L-phenylalanine metabolic process (GO:0006558)7.18566766
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.18566766
6aromatic amino acid family catabolic process (GO:0009074)6.74454159
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.48793118
8* glucuronate metabolic process (GO:0019585)6.42272624
9* uronic acid metabolic process (GO:0006063)6.42272624
10* drug metabolic process (GO:0017144)6.16386748
11tryptophan catabolic process (GO:0006569)6.05129672
12indole-containing compound catabolic process (GO:0042436)6.05129672
13indolalkylamine catabolic process (GO:0046218)6.05129672
14kynurenine metabolic process (GO:0070189)5.94153679
15bile acid biosynthetic process (GO:0006699)5.86883761
16oxidative demethylation (GO:0070989)5.78674509
17tryptophan metabolic process (GO:0006568)5.70764795
18high-density lipoprotein particle remodeling (GO:0034375)5.70141270
19urea cycle (GO:0000050)5.69399805
20urea metabolic process (GO:0019627)5.69399805
21glyoxylate metabolic process (GO:0046487)5.65487335
22alpha-linolenic acid metabolic process (GO:0036109)5.64631050
23negative regulation of fibrinolysis (GO:0051918)5.57588318
24regulation of fibrinolysis (GO:0051917)5.35508541
25peptidyl-glutamic acid carboxylation (GO:0017187)5.35273407
26protein carboxylation (GO:0018214)5.35273407
27sulfur amino acid catabolic process (GO:0000098)5.35020216
28cysteine metabolic process (GO:0006534)5.30916436
29polyketide metabolic process (GO:0030638)5.25093477
30doxorubicin metabolic process (GO:0044598)5.25093477
31daunorubicin metabolic process (GO:0044597)5.25093477
32nitrogen cycle metabolic process (GO:0071941)5.23010147
33phenylpropanoid metabolic process (GO:0009698)5.18096248
34bile acid metabolic process (GO:0008206)5.12724614
35complement activation, alternative pathway (GO:0006957)5.11569236
36regulation of protein activation cascade (GO:2000257)5.09698276
37regulation of cholesterol esterification (GO:0010872)5.09293319
38serine family amino acid catabolic process (GO:0009071)5.08743108
39reverse cholesterol transport (GO:0043691)4.94312512
40aromatic amino acid family metabolic process (GO:0009072)4.90205930
41regulation of triglyceride catabolic process (GO:0010896)4.88816014
42macromolecular complex remodeling (GO:0034367)4.87735672
43plasma lipoprotein particle remodeling (GO:0034369)4.87735672
44protein-lipid complex remodeling (GO:0034368)4.87735672
45homocysteine metabolic process (GO:0050667)4.83221228
46fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.83096360
47tyrosine metabolic process (GO:0006570)4.77762647
48negative regulation of protein activation cascade (GO:2000258)4.77341596
49aminoglycoside antibiotic metabolic process (GO:0030647)4.74079627
50regulation of complement activation (GO:0030449)4.73409715
51negative regulation of cholesterol transport (GO:0032375)4.73333981
52negative regulation of sterol transport (GO:0032372)4.73333981
53phospholipid efflux (GO:0033700)4.72297000
54ethanol metabolic process (GO:0006067)4.67444725
55amino-acid betaine metabolic process (GO:0006577)4.65404307
56triglyceride homeostasis (GO:0070328)4.62653929
57acylglycerol homeostasis (GO:0055090)4.62653929
58alpha-amino acid catabolic process (GO:1901606)4.61845335
59* flavonoid metabolic process (GO:0009812)4.58656584
60lysine catabolic process (GO:0006554)4.56308984
61lysine metabolic process (GO:0006553)4.56308984
62S-adenosylmethionine metabolic process (GO:0046500)4.56244628
63bile acid and bile salt transport (GO:0015721)4.49702140
64cellular ketone body metabolic process (GO:0046950)4.49311368
65alkaloid metabolic process (GO:0009820)4.47804505
66plasma lipoprotein particle clearance (GO:0034381)4.45449089
67positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.36529397
68cholesterol efflux (GO:0033344)4.35235175
69glycine metabolic process (GO:0006544)4.35137276
70drug catabolic process (GO:0042737)4.32901201
71imidazole-containing compound metabolic process (GO:0052803)4.31513097
72indolalkylamine metabolic process (GO:0006586)4.29216112
73regulation of humoral immune response (GO:0002920)4.27590622
74coenzyme catabolic process (GO:0009109)4.26209858
75cellular amino acid catabolic process (GO:0009063)4.24805906
76glutamate metabolic process (GO:0006536)4.21904226
77opsonization (GO:0008228)4.21194388
78cellular biogenic amine catabolic process (GO:0042402)4.20121204
79amine catabolic process (GO:0009310)4.20121204
80plasma lipoprotein particle assembly (GO:0034377)4.15077033
81serine family amino acid metabolic process (GO:0009069)4.12005684
82low-density lipoprotein particle remodeling (GO:0034374)4.11576202
83cytolysis (GO:0019835)4.08817471
84arginine metabolic process (GO:0006525)4.02449017
85cellular modified amino acid catabolic process (GO:0042219)4.02073350
86hormone catabolic process (GO:0042447)4.01484141
87ethanol oxidation (GO:0006069)4.01395927
88negative regulation of blood coagulation (GO:0030195)3.98933904
89negative regulation of hemostasis (GO:1900047)3.98933904
90fibrinolysis (GO:0042730)3.98053451
91serine family amino acid biosynthetic process (GO:0009070)3.97259635
92regulation of plasminogen activation (GO:0010755)3.96924679
93dicarboxylic acid biosynthetic process (GO:0043650)3.95696633
94aldehyde catabolic process (GO:0046185)3.94853813
95* benzene-containing compound metabolic process (GO:0042537)3.90314975
96* acute-phase response (GO:0006953)3.90094115
97ketone body metabolic process (GO:1902224)3.88874049
98very-low-density lipoprotein particle assembly (GO:0034379)3.88242407
99positive regulation of lipid catabolic process (GO:0050996)3.86065486
100negative regulation of lipase activity (GO:0060192)3.85717110
101regulation of bile acid biosynthetic process (GO:0070857)3.85223015
102primary alcohol catabolic process (GO:0034310)3.84141130
103cholesterol homeostasis (GO:0042632)3.82816024
104positive regulation of triglyceride lipase activity (GO:0061365)3.82659725
105positive regulation of lipoprotein lipase activity (GO:0051006)3.82659725
106negative regulation of complement activation (GO:0045916)3.81556980
107blood coagulation, intrinsic pathway (GO:0007597)3.80693975
108disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.78194269
109killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.78194269
110phospholipid homeostasis (GO:0055091)3.77930705
111sterol homeostasis (GO:0055092)3.76498296
112drug transmembrane transport (GO:0006855)3.74875243
113carboxylic acid catabolic process (GO:0046395)3.74605755
114organic acid catabolic process (GO:0016054)3.74605755
115exogenous drug catabolic process (GO:0042738)3.73596508
116heme transport (GO:0015886)3.73530941
117short-chain fatty acid metabolic process (GO:0046459)3.73302671
118protein-lipid complex assembly (GO:0065005)3.72573226
119epoxygenase P450 pathway (GO:0019373)3.71585840
120plasma lipoprotein particle organization (GO:0071827)3.71481315
121regulation of cholesterol homeostasis (GO:2000188)3.67524136
122negative regulation of wound healing (GO:0061045)3.65032657
123negative regulation of coagulation (GO:0050819)3.64917746
124* xenobiotic metabolic process (GO:0006805)3.64374955
125protein activation cascade (GO:0072376)3.62889992
126intestinal cholesterol absorption (GO:0030299)3.60974227
127acetyl-CoA metabolic process (GO:0006084)3.60892738
128complement activation (GO:0006956)3.60786015
129* cellular glucuronidation (GO:0052695)3.59922040
130complement activation, classical pathway (GO:0006958)3.59879432
131positive regulation of fatty acid beta-oxidation (GO:0032000)3.54106897
132response to nitrosative stress (GO:0051409)3.53707867
133lipoprotein metabolic process (GO:0042157)3.52548637
134sodium-independent organic anion transport (GO:0043252)3.39060470

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.37648592
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.16559826
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.95864422
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.50574456
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.27832343
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.03017657
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.89118888
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.02587392
9* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.84848689
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43435750
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08768164
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.03222326
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8744624
14POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99545933
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94821664
16VDR_22108803_ChIP-Seq_LS180_Human1.91884650
17GBX2_23144817_ChIP-Seq_PC3_Human1.77878435
18ER_23166858_ChIP-Seq_MCF-7_Human1.67882503
19IGF1R_20145208_ChIP-Seq_DFB_Human1.64404905
20FOXA2_19822575_ChIP-Seq_HepG2_Human1.62230993
21CLOCK_20551151_ChIP-Seq_293T_Human1.57951225
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.57901007
23HTT_18923047_ChIP-ChIP_STHdh_Human1.56485937
24ZNF274_21170338_ChIP-Seq_K562_Hela1.52563794
25* NFE2_27457419_Chip-Seq_LIVER_Mouse1.51979404
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49537168
27SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47867297
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45756159
29GATA1_22025678_ChIP-Seq_K562_Human1.45434239
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44505582
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43312832
32HNF4A_19822575_ChIP-Seq_HepG2_Human1.42349368
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40384188
34FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39401125
35* EZH2_27294783_Chip-Seq_NPCs_Mouse1.38274568
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.31396497
37CBP_20019798_ChIP-Seq_JUKART_Human1.29657504
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29657504
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28957995
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27599812
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27214504
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24008391
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19860137
44SOX2_19829295_ChIP-Seq_ESCs_Human1.19679513
45NANOG_19829295_ChIP-Seq_ESCs_Human1.19679513
46TCF4_22108803_ChIP-Seq_LS180_Human1.19080678
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18973680
48STAT3_23295773_ChIP-Seq_U87_Human1.18900056
49P300_19829295_ChIP-Seq_ESCs_Human1.18491901
50PHF8_20622853_ChIP-Seq_HELA_Human1.18434512
51RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17157026
52* CRX_20693478_ChIP-Seq_RETINA_Mouse1.15163916
53HNFA_21074721_ChIP-Seq_CACO-2_Human1.14991397
54KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14335042
55CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.13960459
56NFYA_21822215_ChIP-Seq_K562_Human1.13539850
57IRF1_19129219_ChIP-ChIP_H3396_Human1.12581091
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.10909930
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10909930
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10901928
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10846001
62ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10371145
63ETV1_20927104_ChIP-Seq_GIST48_Human1.08861217
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08650793
65AR_25329375_ChIP-Seq_VCAP_Human1.06538158
66TCF4_23295773_ChIP-Seq_U87_Human1.05706507
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05514760
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05036083
69FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04044680
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03957984
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03633832
72* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03100220
73SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02170731
74GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00518703
75* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00345332
76CBX2_22325352_ChIP-Seq_293T-Rex_Human1.00033734
77GATA6_21074721_ChIP-Seq_CACO-2_Human0.99113531
78SMAD4_21799915_ChIP-Seq_A2780_Human0.98887293
79TP53_18474530_ChIP-ChIP_U2OS_Human0.98585794
80SMAD4_21741376_ChIP-Seq_EPCs_Human0.97808199
81PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.97112036
82NFYB_21822215_ChIP-Seq_K562_Human0.96968532
83STAT3_18555785_Chip-Seq_ESCs_Mouse0.96889260
84* P53_22387025_ChIP-Seq_ESCs_Mouse0.96535272
85NANOG_18555785_Chip-Seq_ESCs_Mouse0.93782923
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93417653
87CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92811590
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92329034
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91494688
90SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91376100
91* OCT4_18555785_Chip-Seq_ESCs_Mouse0.90867523
92P300_18555785_Chip-Seq_ESCs_Mouse0.90745466
93GATA4_25053715_ChIP-Seq_YYC3_Human0.90377495
94PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90235968
95AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84863361
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82766034
97IRF8_22096565_ChIP-ChIP_GC-B_Human0.82610756
98RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82423262
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81061658
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77727211
101ZNF263_19887448_ChIP-Seq_K562_Human0.77462564
102* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76648079
103Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76177865
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75271245
105RARA_24833708_ChIP-Seq_LIVER_Mouse0.74718188
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73581890
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71081893
108ESR2_21235772_ChIP-Seq_MCF-7_Human0.70626386
109AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70223410
110SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68796661
111RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.66888602
112NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.65497563
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65398651
114NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65398651
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.64127493
116NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.62988755
117BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.62884318
118RARB_24833708_ChIP-Seq_LIVER_Mouse0.62646570
119RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61216447
120CEBPB_22108803_ChIP-Seq_LS180_Human0.59887354
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.59600614
122EGR1_19032775_ChIP-ChIP_M12_Human0.55723453
123FOXA1_25552417_ChIP-Seq_VCAP_Human0.54906838
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.54783652
125LXR_22292898_ChIP-Seq_THP-1_Human0.54308044
126FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53626503
127AR_20517297_ChIP-Seq_VCAP_Human0.51981281
128MYC_19915707_ChIP-ChIP_AK7_Human0.51826987
129FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51109161
130ESET_19884257_ChIP-Seq_ESCs_Mouse0.50054343
131STAT1_17558387_ChIP-Seq_HELA_Human0.49596994
132CBP_21632823_ChIP-Seq_H3396_Human0.48927163
133PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.48125515
134GATA6_25053715_ChIP-Seq_YYC3_Human0.47862843
135STAT3_1855785_ChIP-Seq_MESCs_Mouse0.47681704
136PPAR_26484153_Chip-Seq_NCI-H1993_Human0.47600408
137ESR1_21235772_ChIP-Seq_MCF-7_Human0.47599441
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.45178717
139FOXO3_23340844_ChIP-Seq_DLD1_Human0.45072941
140GATA1_19941826_ChIP-Seq_K562_Human0.45045895
141* P53_21459846_ChIP-Seq_SAOS-2_Human0.45040256
142* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44810224
143PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44151520
144GATA2_19941826_ChIP-Seq_K562_Human0.44130186
145ESR1_20079471_ChIP-ChIP_T-47D_Human0.43958748
146BCAT_22108803_ChIP-Seq_LS180_Human0.43022569
147TAF15_26573619_Chip-Seq_HEK293_Human0.42674276
148SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41494471
149TAF2_19829295_ChIP-Seq_ESCs_Human0.41133154
150* GATA1_19941827_ChIP-Seq_MEL_Mouse0.39843163
151SOX2_20726797_ChIP-Seq_SW620_Human0.39655536
152ERG_21242973_ChIP-ChIP_JURKAT_Human0.39161140
153* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.38483625
154LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.37289246
155MYC_27129775_Chip-Seq_CORNEA_Mouse0.37131106
156FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.35861199
157GATA3_24758297_ChIP-Seq_MCF-7_Human0.35122637
158NCOR_22424771_ChIP-Seq_293T_Human0.35090484
159STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.34978091
160SPI1_26923725_Chip-Seq_HPCs_Mouse0.34277537
161CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.34178734
162SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.34077471
163* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.33930803
164* CDX2_22108803_ChIP-Seq_LS180_Human0.33618933

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.32582293
2MP0005360_urolithiasis7.59626605
3MP0005085_abnormal_gallbladder_physiolo6.45058520
4MP0005365_abnormal_bile_salt6.17585936
5MP0008875_abnormal_xenobiotic_pharmacok5.38588780
6MP0003806_abnormal_nucleotide_metabolis4.08878825
7MP0003252_abnormal_bile_duct3.91444060
8MP0010329_abnormal_lipoprotein_level3.58878825
9MP0009840_abnormal_foam_cell3.34658360
10MP0005083_abnormal_biliary_tract3.05332653
11MP0003195_calcinosis2.79236994
12MP0005332_abnormal_amino_acid2.73320192
13MP0001666_abnormal_nutrient_absorption2.69312925
14MP0003191_abnormal_cellular_cholesterol2.26068137
15MP0004019_abnormal_vitamin_homeostasis2.17051301
16MP0000609_abnormal_liver_physiology2.15085512
17MP0002118_abnormal_lipid_homeostasis2.09554652
18MP0002138_abnormal_hepatobiliary_system1.91784554
19MP0003868_abnormal_feces_composition1.90408957
20MP0005319_abnormal_enzyme/_coenzyme1.80836741
21MP0001764_abnormal_homeostasis1.65428842
22MP0009697_abnormal_copulation1.58865384
23MP0005451_abnormal_body_composition1.56663960
24MP0005584_abnormal_enzyme/coenzyme_acti1.54776488
25MP0003011_delayed_dark_adaptation1.40366184
26MP0003656_abnormal_erythrocyte_physiolo1.24058667
27MP0009643_abnormal_urine_homeostasis1.23350297
28MP0003186_abnormal_redox_activity1.21013106
29MP0003705_abnormal_hypodermis_morpholog1.16444822
30MP0000598_abnormal_liver_morphology1.15839677
31MP0000604_amyloidosis1.07475997
32MP0005647_abnormal_sex_gland1.06719076
33MP0009764_decreased_sensitivity_to1.05476152
34MP0002254_reproductive_system_inflammat1.04919192
35MP0009763_increased_sensitivity_to0.99909462
36MP0005636_abnormal_mineral_homeostasis0.91506718
37MP0010368_abnormal_lymphatic_system0.87678554
38MP0005551_abnormal_eye_electrophysiolog0.87406216
39MP0008469_abnormal_protein_level0.86815990
40MP0009642_abnormal_blood_homeostasis0.86440217
41MP0005408_hypopigmentation0.83953218
42MP0005187_abnormal_penis_morphology0.83216674
43MP0003879_abnormal_hair_cell0.80049674
44MP0009765_abnormal_xenobiotic_induced0.79394626
45MP0005670_abnormal_white_adipose0.78636085
46MP0005376_homeostasis/metabolism_phenot0.78452525
47MP0006036_abnormal_mitochondrial_physio0.78436273
48MP0004147_increased_porphyrin_level0.78246548
49MP0002078_abnormal_glucose_homeostasis0.76544565
50MP0005084_abnormal_gallbladder_morpholo0.76321000
51MP0004043_abnormal_pH_regulation0.75842714
52MP0002132_abnormal_respiratory_system0.75597806
53MP0002876_abnormal_thyroid_physiology0.73765144
54MP0002971_abnormal_brown_adipose0.71730515
55MP0005334_abnormal_fat_pad0.67904365
56MP0004130_abnormal_muscle_cell0.67815328
57MP0009053_abnormal_anal_canal0.67574561
58MP0005220_abnormal_exocrine_pancreas0.67345123
59MP0003690_abnormal_glial_cell0.65535750
60MP0001661_extended_life_span0.65314002
61MP0001501_abnormal_sleep_pattern0.64905359
62MP0005535_abnormal_body_temperature0.64009927
63MP0005266_abnormal_metabolism0.63775730
64MP0003329_amyloid_beta_deposits0.62538017
65MP0001986_abnormal_taste_sensitivity0.61225236
66MP0001756_abnormal_urination0.60003361
67MP0000639_abnormal_adrenal_gland0.59184759
68MP0003183_abnormal_peptide_metabolism0.59134106
69MP0005448_abnormal_energy_balance0.58350327
70MP0002822_catalepsy0.57858658
71MP0005377_hearing/vestibular/ear_phenot0.57634891
72MP0003878_abnormal_ear_physiology0.57634891
73MP0005464_abnormal_platelet_physiology0.53992142
74MP0002282_abnormal_trachea_morphology0.53809374
75MP0006035_abnormal_mitochondrial_morpho0.53576573
76MP0009785_altered_susceptibility_to0.52221621
77MP0001485_abnormal_pinna_reflex0.49985246
78MP0003638_abnormal_response/metabolism_0.48074193
79MP0008874_decreased_physiological_sensi0.47952708
80MP0005395_other_phenotype0.46899212
81MP0008873_increased_physiological_sensi0.46268694
82MP0002136_abnormal_kidney_physiology0.46230299
83MP0003718_maternal_effect0.45540516
84MP0004782_abnormal_surfactant_physiolog0.45072725
85MP0008872_abnormal_physiological_respon0.44838783
86MP0010386_abnormal_urinary_bladder0.44439461
87MP0005410_abnormal_fertilization0.43904329
88MP0003436_decreased_susceptibility_to0.42172525
89MP0004142_abnormal_muscle_tone0.42037774
90MP0005248_abnormal_Harderian_gland0.40983912
91MP0002928_abnormal_bile_duct0.40365121
92MP0003953_abnormal_hormone_level0.40243230
93MP0003724_increased_susceptibility_to0.40198962
94MP0002796_impaired_skin_barrier0.39939489
95MP0003075_altered_response_to0.38744327
96MP0005645_abnormal_hypothalamus_physiol0.38653456
97MP0005666_abnormal_adipose_tissue0.37642455
98MP0000427_abnormal_hair_cycle0.37088809
99MP0002837_dystrophic_cardiac_calcinosis0.36749789
100MP0000579_abnormal_nail_morphology0.35397503
101MP0005166_decreased_susceptibility_to0.35149680
102MP0009672_abnormal_birth_weight0.34998218
103MP0001243_abnormal_dermal_layer0.33737352
104MP0009115_abnormal_fat_cell0.33360876
105MP0000230_abnormal_systemic_arterial0.32741071
106MP0003633_abnormal_nervous_system0.32553611
107MP0000249_abnormal_blood_vessel0.32545024
108MP0004381_abnormal_hair_follicle0.32204527
109MP0003646_muscle_fatigue0.31321334
110MP0001853_heart_inflammation0.31277842
111MP0005386_behavior/neurological_phenoty0.31148446
112MP0004924_abnormal_behavior0.31148446
113MP0004883_abnormal_blood_vessel0.30896406
114MP0002102_abnormal_ear_morphology0.30880568
115MP0005646_abnormal_pituitary_gland0.29600467
116MP0001324_abnormal_eye_pigmentation0.29504115
117MP0002168_other_aberrant_phenotype0.29449956
118MP0002909_abnormal_adrenal_gland0.29136950
119MP0009745_abnormal_behavioral_response0.29059159
120MP0002970_abnormal_white_adipose0.28985189
121MP0001944_abnormal_pancreas_morphology0.28958702
122MP0006082_CNS_inflammation0.28841428
123MP0010234_abnormal_vibrissa_follicle0.28453186
124MP0009384_cardiac_valve_regurgitation0.28361153
125MP0001845_abnormal_inflammatory_respons0.28053652
126MP0001881_abnormal_mammary_gland0.27960095
127MP0000538_abnormal_urinary_bladder0.27539026
128MP0005167_abnormal_blood-brain_barrier0.27059579
129MP0002060_abnormal_skin_morphology0.26576909
130MP0004264_abnormal_extraembryonic_tissu0.25050186

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.41864744
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.38627286
3Intrahepatic cholestasis (HP:0001406)7.27861580
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.74102054
5Hypobetalipoproteinemia (HP:0003563)6.60389728
6Prolonged partial thromboplastin time (HP:0003645)6.55318120
7Xanthomatosis (HP:0000991)6.31615327
8Hyperlipoproteinemia (HP:0010980)5.59810424
9Complement deficiency (HP:0004431)4.99571889
10Hypolipoproteinemia (HP:0010981)4.91178317
11Joint hemorrhage (HP:0005261)4.78159184
12Hyperammonemia (HP:0001987)4.64651116
13Epidermoid cyst (HP:0200040)4.59064030
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.48526011
15Abnormality of the common coagulation pathway (HP:0010990)4.40054233
16Abnormality of methionine metabolism (HP:0010901)4.33704308
17Hyperglycinemia (HP:0002154)4.32668749
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.27770582
19Ketosis (HP:0001946)4.27340957
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.25798920
21Hypoalphalipoproteinemia (HP:0003233)4.25051666
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.19446760
23Fat malabsorption (HP:0002630)4.14631617
24Hyperglycinuria (HP:0003108)3.93615941
25Abnormality of glycine metabolism (HP:0010895)3.90005630
26Abnormality of serine family amino acid metabolism (HP:0010894)3.90005630
27Abnormality of pyrimidine metabolism (HP:0004353)3.87278397
28Conjugated hyperbilirubinemia (HP:0002908)3.86634115
29Hypoglycemic coma (HP:0001325)3.85649491
30Hypercholesterolemia (HP:0003124)3.76831844
31Abnormality of the intrinsic pathway (HP:0010989)3.71266604
32Abnormality of complement system (HP:0005339)3.64948333
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.39439168
34Abnormality of fatty-acid metabolism (HP:0004359)3.34666496
35* Hyperbilirubinemia (HP:0002904)3.13561021
36Abnormality of nucleobase metabolism (HP:0010932)3.09410300
37Delayed CNS myelination (HP:0002188)3.09367873
38Steatorrhea (HP:0002570)3.05963186
39Fair hair (HP:0002286)3.02993822
40Abnormality of serum amino acid levels (HP:0003112)3.02366338
41Ketoacidosis (HP:0001993)3.02307223
42Hepatocellular carcinoma (HP:0001402)2.96146879
43Spontaneous abortion (HP:0005268)2.93016269
44Myocardial infarction (HP:0001658)2.91105586
45Hypochromic microcytic anemia (HP:0004840)2.83675382
46Skin nodule (HP:0200036)2.82052744
47Metabolic acidosis (HP:0001942)2.80088920
48Acanthocytosis (HP:0001927)2.71765500
49Abnormality of purine metabolism (HP:0004352)2.70476251
50Vascular calcification (HP:0004934)2.62720056
51Lethargy (HP:0001254)2.61135631
52Dicarboxylic aciduria (HP:0003215)2.59667096
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.59667096
54Glycosuria (HP:0003076)2.59103146
55Abnormality of urine glucose concentration (HP:0011016)2.59103146
56Systemic lupus erythematosus (HP:0002725)2.58021006
57Glomerulonephritis (HP:0000099)2.50412992
58Abnormal gallbladder morphology (HP:0012437)2.49117812
59Spastic diplegia (HP:0001264)2.47222272
60Hypoglycemic seizures (HP:0002173)2.46412159
61Cerebral edema (HP:0002181)2.42186199
62Cholelithiasis (HP:0001081)2.41930336
63Mitral stenosis (HP:0001718)2.37616326
64Irritability (HP:0000737)2.37160340
65Malnutrition (HP:0004395)2.36447208
66Gout (HP:0001997)2.35946355
67Cholecystitis (HP:0001082)2.35699092
68Abnormal gallbladder physiology (HP:0012438)2.35699092
69Cardiovascular calcification (HP:0011915)2.32888398
70Amyloidosis (HP:0011034)2.30053625
71Neonatal onset (HP:0003623)2.29941538
72Esophageal varix (HP:0002040)2.22583420
73Generalized hypopigmentation of hair (HP:0011358)2.22432748
74Gingival bleeding (HP:0000225)2.19296125
75Facial shape deformation (HP:0011334)2.19097479
76Potter facies (HP:0002009)2.19097479
77Menorrhagia (HP:0000132)2.17984010
78Brushfield spots (HP:0001088)2.16418701
79Late onset (HP:0003584)2.15281418
80Pancreatitis (HP:0001733)2.13251890
81Poikilocytosis (HP:0004447)2.12025707
82Osteomalacia (HP:0002749)2.11470931
83Recurrent gram-negative bacterial infections (HP:0005420)2.08524604
84Sensorimotor neuropathy (HP:0007141)2.08458126
85Vomiting (HP:0002013)2.06270532
86Arthropathy (HP:0003040)2.05210133
87Joint swelling (HP:0001386)2.04737952
88Enlarged kidneys (HP:0000105)2.04737693
89Thrombophlebitis (HP:0004418)2.04210775
90Hyperphosphaturia (HP:0003109)2.04197263
91Generalized aminoaciduria (HP:0002909)2.03189574
92Bile duct proliferation (HP:0001408)2.01704404
93Abnormal biliary tract physiology (HP:0012439)2.01704404
94Abnormality of the gallbladder (HP:0005264)2.00572015
95Opisthotonus (HP:0002179)2.00039265
96Hyperinsulinemic hypoglycemia (HP:0000825)1.99594860
97Hemorrhage of the eye (HP:0011885)1.98697868
98Hyperventilation (HP:0002883)1.97661554
99Rickets (HP:0002748)1.95757830
100Hydroxyprolinuria (HP:0003080)1.94636441
101Abnormality of proline metabolism (HP:0010907)1.94636441
102Hypothermia (HP:0002045)1.93891355
103Pulmonary embolism (HP:0002204)1.93197638
104Abnormal cartilage morphology (HP:0002763)1.92140438
105Abnormality of iron homeostasis (HP:0011031)1.90515514
106Alkalosis (HP:0001948)1.89368209
107Abnormality of transition element cation homeostasis (HP:0011030)1.87871968
108Reduced antithrombin III activity (HP:0001976)1.87225870
109Renal cortical cysts (HP:0000803)1.85421261
110Hypophosphatemic rickets (HP:0004912)1.84693995
111Elevated hepatic transaminases (HP:0002910)1.80691780
112Nephritis (HP:0000123)1.79876486
113Abnormal enzyme/coenzyme activity (HP:0012379)1.79285108
114Abnormality of vitamin metabolism (HP:0100508)1.79228149
115Proximal tubulopathy (HP:0000114)1.76637100
116Reticulocytosis (HP:0001923)1.75941876
117Status epilepticus (HP:0002133)1.75421228
118Neonatal hypoglycemia (HP:0001998)1.71707409
119Increased serum ferritin (HP:0003281)1.70674212
120Widely patent fontanelles and sutures (HP:0004492)1.68126807
121Abnormality of alanine metabolism (HP:0010916)1.67401224
122Hyperalaninemia (HP:0003348)1.67401224
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67401224
124Purpura (HP:0000979)1.67113305
125Abnormal urine phosphate concentration (HP:0012599)1.66801796
126Abnormality of the renal cortex (HP:0011035)1.65934054
127Blue irides (HP:0000635)1.63001166
128Elevated alkaline phosphatase (HP:0003155)1.57593616
129Abnormality of alkaline phosphatase activity (HP:0004379)1.53977435

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.05030799
2SIK14.57351561
3FGFR44.46323207
4ERN14.15490701
5ACVR1B4.09069779
6MAP4K23.12671361
7TAOK33.07917765
8INSRR3.01911404
9ADRBK22.86750476
10ERBB42.67052264
11PKN22.47928184
12MST1R2.39059875
13MAP2K42.31725951
14FLT32.01658754
15NUAK12.00084106
16CASK1.97680244
17OXSR11.86789608
18BMPR1B1.86336006
19WNK31.84432887
20MAPK111.83669804
21PIK3CG1.81856414
22FRK1.76502279
23TRIB31.76272043
24TYK21.69192034
25STK391.67616541
26LATS11.66918672
27DAPK21.58909856
28PTK61.57423879
29NTRK31.51176099
30ZAK1.47244775
31ABL21.45647838
32FGFR21.41000342
33IRAK11.34022133
34WNK41.33897361
35KDR1.33216750
36NEK91.31216569
37MAPK131.30952801
38MAP3K71.24114076
39GRK61.20731853
40JAK21.19268474
41PRKAA21.18721690
42MAP3K101.15601943
43NLK1.12396886
44MAP3K41.09657857
45FER1.07733898
46TBK11.06882299
47BCR1.06063697
48MAP2K31.06049722
49PINK11.05373138
50TXK1.04360478
51ERBB21.03672001
52MAPK41.01526398
53MAP3K140.98744627
54JAK10.98247528
55TLK10.95872553
56CAMKK20.94621526
57MET0.93787237
58PRKCE0.92683648
59PRKCZ0.92308844
60MAP3K30.89661333
61EPHB10.87466916
62MAP3K120.84498708
63STK38L0.82550016
64CDK60.81992705
65ADRBK10.81392346
66MAP3K110.79249709
67MAPK120.78789066
68MAP2K60.78768028
69PRKACG0.77542664
70RIPK10.77338740
71CSK0.75981946
72TNK20.74584866
73MAPK150.73164192
74DYRK1B0.72964175
75PDK20.72864766
76MAPKAPK30.72747604
77TIE10.71730155
78PRKG10.71640251
79EPHA30.70542579
80PRKACA0.70463464
81BRSK20.69401907
82CAMK1D0.68172968
83CAMK2G0.68126995
84MST40.68081683
85PRKAA10.67278666
86GSK3A0.66623331
87TNIK0.64479203
88TRPM70.61633652
89SGK30.61559941
90IRAK30.61107775
91PTK20.60454428
92NEK10.58906567
93PTK2B0.58733846
94FGFR30.56899940
95TGFBR20.56567114
96MAPK70.56451712
97MUSK0.56181451
98IKBKE0.54394948
99CSF1R0.53987439
100PDPK10.53404412
101STK380.52991064
102EPHA40.52304831
103PRKG20.51409726
104PRKCQ0.51293423
105STK30.51202041
106EIF2AK30.50214784
107GRK10.49954113
108MAP2K70.49921146
109CSNK1G10.46814465
110MAP2K10.46667264
111IKBKB0.46568673
112CSNK1A10.46250097
113RET0.45155127
114MAP3K130.44138836
115TAOK20.44020786
116CSNK1D0.43876234
117IGF1R0.43847506
118PRKCB0.42488225
119MAP3K50.41783008
120SGK20.40860069
121ICK0.39777358
122PRKACB0.39146701
123CDK40.38627660
124PBK0.37988838
125CAMK2A0.37877576
126TEC0.35089205
127PRKCG0.35060096
128MAP3K60.34439489
129MAP2K20.34394627
130PDK10.34350130
131PIK3CA0.33126551
132DYRK20.32537940
133MTOR0.32510937
134ERBB30.32088657
135MYLK0.31860059
136EGFR0.31289973
137MAP3K10.30840745
138CSNK1E0.29623819
139CAMK40.28827044
140PDK40.28452639
141PDK30.28452639
142PRKCA0.28427539
143SGK2230.27561786
144SGK4940.27561786
145CHUK0.27416321
146RPS6KA30.26696632
147MATK0.26458835
148CSNK1G20.26225167
149MAP3K20.25990117
150PKN10.24977743
151AKT30.24868149
152CSNK1G30.22078593
153BMX0.21790584
154PAK30.21471627
155ABL10.20249976

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.44265802
2Nitrogen metabolism_Homo sapiens_hsa009103.64958270
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.35153578
4* Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.23135819
5Arginine biosynthesis_Homo sapiens_hsa002203.08174695
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.79575727
7Tryptophan metabolism_Homo sapiens_hsa003802.73957758
8Complement and coagulation cascades_Homo sapiens_hsa046102.69055643
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.60427063
10Fatty acid degradation_Homo sapiens_hsa000712.51788969
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50776069
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.38411640
13Butanoate metabolism_Homo sapiens_hsa006502.16037348
14* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14245391
15* Pentose and glucuronate interconversions_Homo sapiens_hsa000402.11725712
16Peroxisome_Homo sapiens_hsa041462.07874136
17Caffeine metabolism_Homo sapiens_hsa002321.97486859
18Histidine metabolism_Homo sapiens_hsa003401.97367957
19* Chemical carcinogenesis_Homo sapiens_hsa052041.95744369
20Propanoate metabolism_Homo sapiens_hsa006401.93276901
21* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.93092406
22PPAR signaling pathway_Homo sapiens_hsa033201.90073707
23* Steroid hormone biosynthesis_Homo sapiens_hsa001401.85316012
24Fatty acid metabolism_Homo sapiens_hsa012121.83244980
25beta-Alanine metabolism_Homo sapiens_hsa004101.75235994
26Staphylococcus aureus infection_Homo sapiens_hsa051501.74435234
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73647681
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.70715184
29* Retinol metabolism_Homo sapiens_hsa008301.62441481
30* Drug metabolism - other enzymes_Homo sapiens_hsa009831.62303416
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61161117
32Selenocompound metabolism_Homo sapiens_hsa004501.59336159
33Phenylalanine metabolism_Homo sapiens_hsa003601.57099943
34Bile secretion_Homo sapiens_hsa049761.56457637
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52003284
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48224746
37Sulfur metabolism_Homo sapiens_hsa009201.41092750
38Tyrosine metabolism_Homo sapiens_hsa003501.41020703
39Pyruvate metabolism_Homo sapiens_hsa006201.38067929
40Fatty acid elongation_Homo sapiens_hsa000621.37721775
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.29708571
42Fat digestion and absorption_Homo sapiens_hsa049751.27365458
43ABC transporters_Homo sapiens_hsa020101.24282605
44Steroid biosynthesis_Homo sapiens_hsa001001.24094704
45Folate biosynthesis_Homo sapiens_hsa007901.23769086
46Biosynthesis of amino acids_Homo sapiens_hsa012301.20247102
47* Starch and sucrose metabolism_Homo sapiens_hsa005001.18891088
48Carbon metabolism_Homo sapiens_hsa012001.13587179
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.03089845
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02290298
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.01493326
52Arginine and proline metabolism_Homo sapiens_hsa003301.00066537
53Vitamin digestion and absorption_Homo sapiens_hsa049770.93094991
54Sulfur relay system_Homo sapiens_hsa041220.90576529
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89655434
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87436502
57Vitamin B6 metabolism_Homo sapiens_hsa007500.83752364
58Lysine degradation_Homo sapiens_hsa003100.82597625
59* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78675173
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72435537
61One carbon pool by folate_Homo sapiens_hsa006700.71767594
62Glycerolipid metabolism_Homo sapiens_hsa005610.70488581
63Glutathione metabolism_Homo sapiens_hsa004800.70258045
64Pentose phosphate pathway_Homo sapiens_hsa000300.59187161
65Fatty acid biosynthesis_Homo sapiens_hsa000610.55074066
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50872291
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49033326
68* Metabolic pathways_Homo sapiens_hsa011000.46056012
69Galactose metabolism_Homo sapiens_hsa000520.30852767
70Fructose and mannose metabolism_Homo sapiens_hsa000510.27428669
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26912564
72Linoleic acid metabolism_Homo sapiens_hsa005910.26695330
73Prion diseases_Homo sapiens_hsa050200.24750948
74Insulin resistance_Homo sapiens_hsa049310.23479759
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.22057578
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19977660
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.16654276
78Serotonergic synapse_Homo sapiens_hsa047260.16492594
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.12953516
80Glucagon signaling pathway_Homo sapiens_hsa049220.09636436
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.04643196
82AMPK signaling pathway_Homo sapiens_hsa041520.02266031
83Sphingolipid metabolism_Homo sapiens_hsa006000.01922343
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.01880274
85Phototransduction_Homo sapiens_hsa047440.00437755
86Pertussis_Homo sapiens_hsa05133-0.2498009
87Ether lipid metabolism_Homo sapiens_hsa00565-0.2463574
88Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2447401
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2221056
90Mineral absorption_Homo sapiens_hsa04978-0.2153174
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1964000
92Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1931811
93Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1869138
94Hepatitis C_Homo sapiens_hsa05160-0.1750479
95Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1632338
96Regulation of autophagy_Homo sapiens_hsa04140-0.1624243
97Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1619991
98Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1612209
99Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1522536
100African trypanosomiasis_Homo sapiens_hsa05143-0.1398460
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1195731
102Circadian rhythm_Homo sapiens_hsa04710-0.1042770
103Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1032041
104Insulin signaling pathway_Homo sapiens_hsa04910-0.1025210
105Renin-angiotensin system_Homo sapiens_hsa04614-0.0926335
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0830730
107Protein digestion and absorption_Homo sapiens_hsa04974-0.0627547
108Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0560655
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0470856
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0386611
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0322752

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