UGCG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that catalyzes the first glycosylation step in the biosynthesis of glycosphingolipids, which are membrane components containing lipid and sugar moieties. The product of this reaction is glucosylceramide, which is the core structure of many glycosphingolipids. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma production (GO:0032609)5.70700110
2positive regulation of macrophage activation (GO:0043032)5.58417854
3membrane raft organization (GO:0031579)4.69380225
4response to interleukin-15 (GO:0070672)4.68403014
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.61550957
6negative regulation of cell killing (GO:0031342)4.61550957
7cellular response to interleukin-15 (GO:0071350)4.39778613
8UDP-N-acetylglucosamine metabolic process (GO:0006047)4.22653423
9cell adhesion mediated by integrin (GO:0033627)4.16388734
10melanin biosynthetic process (GO:0042438)4.15994601
11regulation of integrin-mediated signaling pathway (GO:2001044)4.12157075
12regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.95564452
13negative T cell selection (GO:0043383)3.90584881
14cellular response to interferon-alpha (GO:0035457)3.88011848
15nuclear pore complex assembly (GO:0051292)3.86674450
16melanin metabolic process (GO:0006582)3.85927887
17keratinocyte development (GO:0003334)3.84201959
18regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.82405147
19negative thymic T cell selection (GO:0045060)3.78362850
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.77920157
21positive regulation of protein autophosphorylation (GO:0031954)3.72544543
22positive regulation of gamma-delta T cell activation (GO:0046645)3.62200454
23positive T cell selection (GO:0043368)3.58100884
24regulation of isotype switching to IgG isotypes (GO:0048302)3.55546819
25keratinization (GO:0031424)3.54066760
26positive thymic T cell selection (GO:0045059)3.51605373
27COPII vesicle coating (GO:0048208)3.49777158
28desmosome organization (GO:0002934)3.43872189
29ER overload response (GO:0006983)3.42421767
30secondary metabolite biosynthetic process (GO:0044550)3.37360830
31thymic T cell selection (GO:0045061)3.35846184
32dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.33278041
33sphingosine metabolic process (GO:0006670)3.27947439
34fibroblast migration (GO:0010761)3.27023046
35regulation of macrophage activation (GO:0043030)3.22042975
36positive regulation of glycoprotein metabolic process (GO:1903020)3.16171824
37positive regulation of glycoprotein biosynthetic process (GO:0010560)3.15035215
38nuclear pore organization (GO:0006999)3.12310337
39regulation of establishment of cell polarity (GO:2000114)3.11464869
40regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.10989282
41T cell selection (GO:0045058)3.08198279
42regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.07933959
43regulation of response to interferon-gamma (GO:0060330)3.00914881
44iron ion import (GO:0097286)3.00584139
45regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.99683511
46positive regulation of isotype switching (GO:0045830)2.99079183
47positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.97000685
48regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.97000685
49monoubiquitinated protein deubiquitination (GO:0035520)2.95210746
50diol metabolic process (GO:0034311)2.94913484
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.94507717
52regulation of metalloenzyme activity (GO:0048552)2.94308053
53chronic inflammatory response (GO:0002544)2.93375425
54regulation of water loss via skin (GO:0033561)2.93144699
55mitotic sister chromatid cohesion (GO:0007064)2.92681589
56protein localization to endosome (GO:0036010)2.91973164
57sphingoid metabolic process (GO:0046519)2.91850067
58pore complex assembly (GO:0046931)2.88573365
59regulation of T cell tolerance induction (GO:0002664)2.88397264
60platelet-derived growth factor receptor signaling pathway (GO:0048008)2.86387561
61pyrimidine-containing compound transmembrane transport (GO:0072531)2.83549713
62proteasome assembly (GO:0043248)2.82955396
63regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.81490667
64regulation of gamma-delta T cell differentiation (GO:0045586)2.81114494
65myoblast migration (GO:0051451)2.81067166
66negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.80874979
67negative regulation of T cell mediated immunity (GO:0002710)2.78371780
68lymphocyte costimulation (GO:0031294)2.77316570
69regulation of RNA export from nucleus (GO:0046831)2.75395429
70regulation of protein autophosphorylation (GO:0031952)2.74596149
71T cell costimulation (GO:0031295)2.72677037
72positive regulation of actin filament depolymerization (GO:0030836)2.72608574
73regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.72000234
74regulation of natural killer cell mediated immunity (GO:0002715)2.72000234
75positive regulation of DNA recombination (GO:0045911)2.71056981
76cellular response to arsenic-containing substance (GO:0071243)2.70372945
77negative regulation of chondrocyte differentiation (GO:0032331)2.70204856
78nucleotide-sugar biosynthetic process (GO:0009226)2.68769390
79negative regulation of JUN kinase activity (GO:0043508)2.68181355
80mitotic metaphase plate congression (GO:0007080)2.67808816
81definitive hemopoiesis (GO:0060216)2.67805968
82regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.65220869
83hippo signaling (GO:0035329)2.64171348
84wound healing, spreading of epidermal cells (GO:0035313)2.64140004
85natural killer cell activation (GO:0030101)2.63306973
86regulation of spindle organization (GO:0090224)2.62969678
87regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.62655698
88chondrocyte proliferation (GO:0035988)2.62326236
89regulation of B cell receptor signaling pathway (GO:0050855)2.62225418
90regulation of fibroblast apoptotic process (GO:2000269)2.62052645
91intestinal epithelial cell development (GO:0060576)2.61324520
92cellular defense response (GO:0006968)2.61179644
93heterotypic cell-cell adhesion (GO:0034113)2.61038640
94smooth muscle tissue development (GO:0048745)2.60860581
95muscle cell cellular homeostasis (GO:0046716)2.60339303
96collagen fibril organization (GO:0030199)2.59732039
97regulation of T cell receptor signaling pathway (GO:0050856)2.59317971
98positive regulation of mitotic sister chromatid separation (GO:1901970)2.57973344
99positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.57973344
100positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.57973344
101histone H3-K9 demethylation (GO:0033169)2.57279195
102embryonic cranial skeleton morphogenesis (GO:0048701)2.56509613
103activated T cell proliferation (GO:0050798)2.56496666
104regulation of transforming growth factor beta1 production (GO:0032908)2.56164836
105diterpenoid biosynthetic process (GO:0016102)2.55953777
106regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.55705681
107regulation of gamma-delta T cell activation (GO:0046643)2.55683329
108natural killer cell mediated cytotoxicity (GO:0042267)2.54153597
109natural killer cell mediated immunity (GO:0002228)2.54153597
110positive regulation of toll-like receptor signaling pathway (GO:0034123)2.53648785
111leukocyte tethering or rolling (GO:0050901)2.53067746
112keratan sulfate catabolic process (GO:0042340)2.52970922
113regulation of mitotic spindle organization (GO:0060236)2.51341284
114regulation of apoptotic process involved in morphogenesis (GO:1902337)2.50896424
115negative regulation of signal transduction by p53 class mediator (GO:1901797)2.50843986
116positive regulation of fibroblast migration (GO:0010763)2.50713241
117T cell receptor signaling pathway (GO:0050852)2.50606773
118endocrine hormone secretion (GO:0060986)2.50590917
119regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.49946405
120regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.49507968
121pericardium development (GO:0060039)2.49440598
122establishment of skin barrier (GO:0061436)2.47200386
123Arp2/3 complex-mediated actin nucleation (GO:0034314)2.47108808
124regulation of translational termination (GO:0006449)2.45287770
125Rap protein signal transduction (GO:0032486)2.43780968
126histone mRNA catabolic process (GO:0071044)2.43295247
127leukocyte cell-cell adhesion (GO:0007159)2.43218615
128positive regulation of granulocyte differentiation (GO:0030854)2.42074120
129corticosteroid receptor signaling pathway (GO:0031958)2.42038078
130tyrosine phosphorylation of STAT protein (GO:0007260)2.41817626
131cytoplasmic mRNA processing body assembly (GO:0033962)2.41575998
132positive regulation of extracellular matrix organization (GO:1903055)2.41441036
133glucocorticoid receptor signaling pathway (GO:0042921)2.41071435
134COPI coating of Golgi vesicle (GO:0048205)2.40900816
135Golgi transport vesicle coating (GO:0048200)2.40900816
136peptidyl-proline hydroxylation (GO:0019511)2.40473113
137protein heterotetramerization (GO:0051290)2.39832853
138mammary gland epithelial cell proliferation (GO:0033598)2.38171064
139regulation of establishment or maintenance of cell polarity (GO:0032878)2.38133992
140membrane budding (GO:0006900)2.37163586
141mesodermal cell differentiation (GO:0048333)2.36888837
142negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.35776215
143T cell migration (GO:0072678)2.35707451
144regulation of nucleobase-containing compound transport (GO:0032239)2.35250601
145keratinocyte proliferation (GO:0043616)2.35018112
146regulation of vitamin D biosynthetic process (GO:0060556)2.34314136
147keratinocyte differentiation (GO:0030216)2.34218228
148protein hydroxylation (GO:0018126)2.33902381
149negative regulation of protein autophosphorylation (GO:0031953)2.33073929
150negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.32897818
151regulation of isotype switching (GO:0045191)2.32815523
152regulation of hippo signaling (GO:0035330)2.32419446
153protein K11-linked deubiquitination (GO:0035871)2.32271556
154regulation of transforming growth factor beta production (GO:0071634)2.31400399
155negative regulation of stem cell proliferation (GO:2000647)2.31161097
156hepatocyte apoptotic process (GO:0097284)2.31120107
157negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.31104481
158negative regulation of T-helper cell differentiation (GO:0045623)2.31104481
159alpha-beta T cell differentiation (GO:0046632)2.30445052
160detection of molecule of bacterial origin (GO:0032490)2.29781298
161protein localization to kinetochore (GO:0034501)2.29005564
162regulation of type B pancreatic cell apoptotic process (GO:2000674)2.28729496
163positive regulation of osteoblast proliferation (GO:0033690)2.28608788
164regulation of transforming growth factor beta2 production (GO:0032909)2.27681662
165vesicle coating (GO:0006901)2.27173824
166alpha-beta T cell activation (GO:0046631)2.26899846
167embryonic hemopoiesis (GO:0035162)2.26808810
168negative regulation of axon extension involved in axon guidance (GO:0048843)2.26589526
169positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.25465556
170T cell homeostasis (GO:0043029)2.25432253
171positive regulation of chromosome segregation (GO:0051984)2.24926465
172negative regulation of dendrite morphogenesis (GO:0050774)2.24845595
173positive regulation of erythrocyte differentiation (GO:0045648)2.23773100
174establishment of chromosome localization (GO:0051303)2.23223069
175metaphase plate congression (GO:0051310)2.22063308
176regulation of protein heterodimerization activity (GO:0043497)2.20876686
177embryonic process involved in female pregnancy (GO:0060136)2.20634824
178leukocyte aggregation (GO:0070486)2.20584350
179positive regulation of macrophage differentiation (GO:0045651)2.20102504
180regulation of alpha-beta T cell proliferation (GO:0046640)2.19744541
181positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.18626920
182skin morphogenesis (GO:0043589)2.18021425
183substrate-dependent cell migration (GO:0006929)2.17216332
184negative regulation of fibroblast apoptotic process (GO:2000270)2.16182409
185membrane disassembly (GO:0030397)2.15986958
186nuclear envelope disassembly (GO:0051081)2.15986958
187T cell differentiation (GO:0030217)2.15939876
188positive regulation of B cell mediated immunity (GO:0002714)2.14554206
189positive regulation of immunoglobulin mediated immune response (GO:0002891)2.14554206
190protein localization to chromosome, centromeric region (GO:0071459)2.13820738
191phospholipid scrambling (GO:0017121)2.13736768

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.80542893
2E2F7_22180533_ChIP-Seq_HELA_Human4.78717874
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.77192522
4* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.70243586
5SMAD_19615063_ChIP-ChIP_OVARY_Human4.29121559
6EGR1_19374776_ChIP-ChIP_THP-1_Human4.23906725
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.82748092
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.67882064
9RBPJ_22232070_ChIP-Seq_NCS_Mouse3.29698490
10TRIM28_21343339_ChIP-Seq_HEK293_Human3.12449762
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.99486349
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.75265520
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.68245290
14RUNX_20019798_ChIP-Seq_JUKART_Human2.53926013
15MYB_26560356_Chip-Seq_TH2_Human2.37398090
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.34528910
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.33090656
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.15597628
19ESR1_21235772_ChIP-Seq_MCF-7_Human2.13806201
20* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.11899558
21MYB_26560356_Chip-Seq_TH1_Human2.11223374
22MYC_22102868_ChIP-Seq_BL_Human2.08536363
23TP63_19390658_ChIP-ChIP_HaCaT_Human1.96786719
24NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.95423200
25NRF2_20460467_ChIP-Seq_MEFs_Mouse1.95423200
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.94315833
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88191223
28TP53_18474530_ChIP-ChIP_U2OS_Human1.83944238
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.78423246
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.77658530
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77194821
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75482442
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72417584
34* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.69594881
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66306692
36TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.66020350
37AHR_22903824_ChIP-Seq_MCF-7_Human1.65785238
38SALL4_18804426_ChIP-ChIP_XEN_Mouse1.63993119
39SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.63442628
40RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.62448435
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59440576
42SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.58426132
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.58426132
44CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.57664350
45ELK1_19687146_ChIP-ChIP_HELA_Human1.57225274
46MAF_26560356_Chip-Seq_TH1_Human1.55963846
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.51784039
48* BRD4_25478319_ChIP-Seq_HGPS_Human1.49705631
49UTX_26944678_Chip-Seq_JUKART_Human1.49705220
50TP63_23658742_ChIP-Seq_EP156T_Human1.49047805
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47944417
52TCF7_22412390_ChIP-Seq_EML_Mouse1.45755104
53* SOX2_20726797_ChIP-Seq_SW620_Human1.43895787
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.40210049
55TCF4_18268006_ChIP-ChIP_LS174T_Human1.39449148
56FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39299128
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38764989
58PKCTHETA_26484144_Chip-Seq_BREAST_Human1.38668091
59* PIAS1_25552417_ChIP-Seq_VCAP_Human1.38487727
60ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36772913
61ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.36630929
62TP53_16413492_ChIP-PET_HCT116_Human1.34727349
63GATA3_27048872_Chip-Seq_THYMUS_Human1.34580592
64RXR_22108803_ChIP-Seq_LS180_Human1.34476150
65IRF8_22096565_ChIP-ChIP_GC-B_Human1.33884958
66JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32445395
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.32297695
68CDX2_22108803_ChIP-Seq_LS180_Human1.31503218
69ELF5_23300383_ChIP-Seq_T47D_Human1.29692134
70CJUN_26792858_Chip-Seq_BT549_Human1.28852639
71SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27893404
72* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27569854
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27459907
74BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26963992
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26915795
76RUNX1_22412390_ChIP-Seq_EML_Mouse1.26804345
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26057457
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25392144
79ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25111138
80EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.24223562
81ESR2_21235772_ChIP-Seq_MCF-7_Human1.24176421
82OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24023222
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.22859064
84CLOCK_20551151_ChIP-Seq_293T_Human1.22652797
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21284884
86* VDR_24787735_ChIP-Seq_THP-1_Human1.19688218
87FLI1_27457419_Chip-Seq_LIVER_Mouse1.18193485
88KDM2B_26808549_Chip-Seq_DND41_Human1.16371130
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.15959368
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.15885763
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13799202
92POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11262842
93AR_21909140_ChIP-Seq_LNCAP_Human1.10878929
94* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10852617
95WT1_19549856_ChIP-ChIP_CCG9911_Human1.10232655
96SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09958371
97* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.09708842
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08833268
99* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08765052
100VDR_22108803_ChIP-Seq_LS180_Human1.07813642
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.07260872
102FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.06217917
103EWS_26573619_Chip-Seq_HEK293_Human1.06074470
104PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04363478
105CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03995103
106* GATA3_24758297_ChIP-Seq_MCF-7_Human1.03593951
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03236016
108PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02389047
109TFEB_21752829_ChIP-Seq_HELA_Human1.02318766
110SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02185220
111CDX2_20551321_ChIP-Seq_CACO-2_Human1.01974129
112CMYC_18555785_Chip-Seq_ESCs_Mouse1.01965168
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01278139
114ATF3_27146783_Chip-Seq_COLON_Human1.00977557
115SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00911981
116E2F1_18555785_Chip-Seq_ESCs_Mouse0.99528134
117PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99266725
118HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98916497
119SOX2_18555785_Chip-Seq_ESCs_Mouse0.98245529
120IRF8_27001747_Chip-Seq_BMDM_Mouse0.96975138
121MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.96930852
122PU_27001747_Chip-Seq_BMDM_Mouse0.96453376
123P300_19829295_ChIP-Seq_ESCs_Human0.96287140
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96194429
125* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95194880
126SPI1_23547873_ChIP-Seq_NB4_Human0.94761404
127* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94587934
128* GATA4_25053715_ChIP-Seq_YYC3_Human0.94215718
129* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93980986
130* UBF1/2_26484160_Chip-Seq_HMECs_Human0.93452738
131STAT3_18555785_Chip-Seq_ESCs_Mouse0.92189351
132HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91938596
133KDM2B_26808549_Chip-Seq_JURKAT_Human0.91547453
134FOXO3_23340844_ChIP-Seq_DLD1_Human0.91454398
135KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91039347
136RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90419765
137GATA3_26560356_Chip-Seq_TH2_Human0.89952200
138SMAD4_21799915_ChIP-Seq_A2780_Human0.89913134
139SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89587881
140CRX_20693478_ChIP-Seq_RETINA_Mouse0.89174140
141CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88144440
142ELK3_25401928_ChIP-Seq_HUVEC_Human0.88056686
143BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87576411
144WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87469669
145NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86044656
146E2F1_21310950_ChIP-Seq_MCF-7_Human0.85861106
147ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85307207
148PRDM14_20953172_ChIP-Seq_ESCs_Human0.84191166
149RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82497778
150* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82453375
151* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.80895040
152RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.80846875
153AR_21572438_ChIP-Seq_LNCaP_Human0.80584253
154JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80573782
155* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.77059369
156VDR_23849224_ChIP-Seq_CD4+_Human0.76920283
157GATA2_21666600_ChIP-Seq_HMVEC_Human0.76903662
158P300_27058665_Chip-Seq_ZR-75-30cells_Human0.76830335
159SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.76519951
160MAF_26560356_Chip-Seq_TH2_Human0.76446177
161CHD1_26751641_Chip-Seq_LNCaP_Human0.75990124
162JUN_21703547_ChIP-Seq_K562_Human0.74814795

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003950_abnormal_plasma_membrane4.85344384
2MP0000372_irregular_coat_pigmentation3.78526521
3MP0005671_abnormal_response_to3.27902454
4MP0005257_abnormal_intraocular_pressure3.00734812
5MP0003191_abnormal_cellular_cholesterol2.93845116
6MP0005408_hypopigmentation2.91426940
7MP0003941_abnormal_skin_development2.79624500
8MP0003763_abnormal_thymus_physiology2.56459710
9MP0010352_gastrointestinal_tract_polyps2.53996477
10MP0010234_abnormal_vibrissa_follicle2.45071000
11MP0010307_abnormal_tumor_latency2.44173652
12MP0005171_absent_coat_pigmentation2.41470716
13MP0005275_abnormal_skin_tensile2.37640460
14MP0000015_abnormal_ear_pigmentation2.35960415
15MP0008438_abnormal_cutaneous_collagen2.30011493
16MP0004272_abnormal_basement_membrane2.25075359
17MP0002877_abnormal_melanocyte_morpholog2.24083723
18MP0003705_abnormal_hypodermis_morpholog2.21367243
19MP0002396_abnormal_hematopoietic_system2.19181907
20MP0004808_abnormal_hematopoietic_stem2.19070269
21MP0006054_spinal_hemorrhage2.10057786
22MP0006082_CNS_inflammation2.03518914
23MP0009333_abnormal_splenocyte_physiolog1.98483904
24MP0004947_skin_inflammation1.89641509
25MP0002090_abnormal_vision1.85117190
26MP0002398_abnormal_bone_marrow1.83433954
27MP0002254_reproductive_system_inflammat1.77220911
28MP0000371_diluted_coat_color1.77156464
29MP0005397_hematopoietic_system_phenotyp1.74576757
30MP0001545_abnormal_hematopoietic_system1.74576757
31MP0002006_tumorigenesis1.73715072
32MP0001800_abnormal_humoral_immune1.69985161
33MP0003448_altered_tumor_morphology1.68171291
34MP0003693_abnormal_embryo_hatching1.65925524
35MP0002166_altered_tumor_susceptibility1.64440201
36MP0002420_abnormal_adaptive_immunity1.63653705
37MP0001819_abnormal_immune_cell1.61797010
38MP0010386_abnormal_urinary_bladder1.61239842
39MP0003806_abnormal_nucleotide_metabolis1.60859416
40MP0005076_abnormal_cell_differentiation1.60300837
41MP0009840_abnormal_foam_cell1.56376355
42MP0000858_altered_metastatic_potential1.56373651
43MP0010678_abnormal_skin_adnexa1.56358302
44MP0002009_preneoplasia1.55835047
45MP0001873_stomach_inflammation1.55801186
46MP0003279_aneurysm1.55775027
47MP0003091_abnormal_cell_migration1.54671717
48MP0000703_abnormal_thymus_morphology1.51813438
49MP0005503_abnormal_tendon_morphology1.51422342
50MP0005164_abnormal_response_to1.50938510
51MP0004510_myositis1.50427973
52MP0005000_abnormal_immune_tolerance1.46269326
53MP0002452_abnormal_antigen_presenting1.43314215
54MP0003300_gastrointestinal_ulcer1.42726106
55MP0002796_impaired_skin_barrier1.42190631
56MP0000427_abnormal_hair_cycle1.40724139
57MP0001853_heart_inflammation1.39955837
58MP0002723_abnormal_immune_serum1.38852719
59MP0000569_abnormal_digit_pigmentation1.38693457
60MP0002722_abnormal_immune_system1.38676471
61MP0005023_abnormal_wound_healing1.36093626
62MP0004957_abnormal_blastocyst_morpholog1.32855602
63MP0000647_abnormal_sebaceous_gland1.31653782
64MP0001835_abnormal_antigen_presentation1.31120697
65MP0000716_abnormal_immune_system1.30482986
66MP0003111_abnormal_nucleus_morphology1.30374165
67MP0005310_abnormal_salivary_gland1.29422950
68MP0003077_abnormal_cell_cycle1.28777378
69MP0003566_abnormal_cell_adhesion1.28357044
70MP0001542_abnormal_bone_strength1.27343746
71MP0002060_abnormal_skin_morphology1.26783483
72MP0009780_abnormal_chondrocyte_physiolo1.26117282
73MP0005197_abnormal_uvea_morphology1.26050814
74MP0002405_respiratory_system_inflammati1.23526749
75MP0000733_abnormal_muscle_development1.23292523
76MP0003656_abnormal_erythrocyte_physiolo1.22764577
77MP0001790_abnormal_immune_system1.22088654
78MP0005387_immune_system_phenotype1.22088654
79MP0000689_abnormal_spleen_morphology1.21633152
80MP0005451_abnormal_body_composition1.20389658
81MP0000749_muscle_degeneration1.19868343
82MP0003303_peritoneal_inflammation1.19371679
83MP0005501_abnormal_skin_physiology1.19348769
84MP0002095_abnormal_skin_pigmentation1.16529804
85MP0004233_abnormal_muscle_weight1.13431299
86MP0008007_abnormal_cellular_replicative1.13277166
87MP0003252_abnormal_bile_duct1.12021310
88MP0000350_abnormal_cell_proliferation1.11588195
89MP0000490_abnormal_crypts_of1.10942687
90MP0010155_abnormal_intestine_physiology1.10677796
91MP0002148_abnormal_hypersensitivity_rea1.09107563
92MP0002429_abnormal_blood_cell1.08279595
93MP0003828_pulmonary_edema1.08015065
94MP0003724_increased_susceptibility_to1.07139087
95MP0002295_abnormal_pulmonary_circulatio1.06935103
96MP0001299_abnormal_eye_distance/1.03376792
97MP0005075_abnormal_melanosome_morpholog1.01843059
98MP0009785_altered_susceptibility_to1.01131077
99MP0001216_abnormal_epidermal_layer0.99983653
100MP0000516_abnormal_urinary_system0.99653754
101MP0005367_renal/urinary_system_phenotyp0.99653754
102MP0005174_abnormal_tail_pigmentation0.99092532
103* MP0002086_abnormal_extraembryonic_tissu0.98741286
104MP0002102_abnormal_ear_morphology0.98416862
105MP0002896_abnormal_bone_mineralization0.97648830
106MP0005165_increased_susceptibility_to0.96474436
107MP0001851_eye_inflammation0.96359880
108MP0005025_abnormal_response_to0.95577568
109MP0000685_abnormal_immune_system0.93742302
110MP0001243_abnormal_dermal_layer0.93236623
111MP0002019_abnormal_tumor_incidence0.93175575
112MP0001958_emphysema0.91031515
113MP0000465_gastrointestinal_hemorrhage0.90903743
114MP0004782_abnormal_surfactant_physiolog0.90671456
115MP0002168_other_aberrant_phenotype0.89843582
116MP0001188_hyperpigmentation0.89669566
117MP0001348_abnormal_lacrimal_gland0.89445660
118MP0000343_altered_response_to0.88685494
119MP0005464_abnormal_platelet_physiology0.88010856
120MP0000627_abnormal_mammary_gland0.87943394
121MP0000767_abnormal_smooth_muscle0.87051295
122MP0003453_abnormal_keratinocyte_physiol0.84873545
123MP0010771_integument_phenotype0.83893233
124MP0001533_abnormal_skeleton_physiology0.83122677
125MP0002998_abnormal_bone_remodeling0.82284333
126MP0003045_fibrosis0.81175513
127MP0005193_abnormal_anterior_eye0.81136399
128MP0005595_abnormal_vascular_smooth0.80327634
129MP0005623_abnormal_meninges_morphology0.80149584
130MP0008057_abnormal_DNA_replication0.79701454
131MP0003123_paternal_imprinting0.79248183
132MP0001324_abnormal_eye_pigmentation0.78917958
133MP0001730_embryonic_growth_arrest0.78684341
134MP0009931_abnormal_skin_appearance0.77457644
135MP0004883_abnormal_blood_vessel0.76645923
136MP0001915_intracranial_hemorrhage0.76332510
137MP0003866_abnormal_defecation0.76265502
138MP0010094_abnormal_chromosome_stability0.76214140
139MP0004381_abnormal_hair_follicle0.76054992
140MP0002419_abnormal_innate_immunity0.76012717
141MP0002332_abnormal_exercise_endurance0.75159765
142MP0009384_cardiac_valve_regurgitation0.74655969
143MP0001191_abnormal_skin_condition0.74544384
144MP0001186_pigmentation_phenotype0.73452453
145MP0004264_abnormal_extraembryonic_tissu0.72622137
146MP0002177_abnormal_outer_ear0.65401589
147MP0002876_abnormal_thyroid_physiology0.65093022
148MP0005187_abnormal_penis_morphology0.64601212
149MP0002282_abnormal_trachea_morphology0.64024846
150MP0000377_abnormal_hair_follicle0.63333400
151MP0005621_abnormal_cell_physiology0.62964338
152MP0005395_other_phenotype0.62379665
153MP0005248_abnormal_Harderian_gland0.61693212
154MP0005508_abnormal_skeleton_morphology0.61370286
155MP0003755_abnormal_palate_morphology0.60833321
156MP0002138_abnormal_hepatobiliary_system0.60524172
157MP0003195_calcinosis0.60232821

Predicted human phenotypes

RankGene SetZ-score
1Follicular hyperkeratosis (HP:0007502)5.49795978
2Tetraparesis (HP:0002273)4.53351429
3Abnormality of placental membranes (HP:0011409)3.64788290
4Amniotic constriction ring (HP:0009775)3.64788290
5Abnormality of nail color (HP:0100643)3.31868422
6Spinal cord lesions (HP:0100561)3.21614174
7Syringomyelia (HP:0003396)3.21614174
8Albinism (HP:0001022)3.16549170
9Premature rupture of membranes (HP:0001788)3.13586706
10Congenital ichthyosiform erythroderma (HP:0007431)2.95912422
11Protrusio acetabuli (HP:0003179)2.95507689
12Osteolytic defects of the phalanges of the hand (HP:0009771)2.83611108
13Osteolytic defects of the hand bones (HP:0009699)2.83611108
14Type 2 muscle fiber atrophy (HP:0003554)2.75754364
15Aortic aneurysm (HP:0004942)2.75670277
16Cardiovascular calcification (HP:0011915)2.74811871
17Abnormality of glycolipid metabolism (HP:0010969)2.72372990
18Abnormality of liposaccharide metabolism (HP:0010968)2.72372990
19Abnormality of glycosphingolipid metabolism (HP:0004343)2.72372990
20Muscle fiber atrophy (HP:0100295)2.67865370
21Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.67775129
22Ocular albinism (HP:0001107)2.65984895
23Fatigable weakness (HP:0003473)2.65951582
24Abnormality of the neuromuscular junction (HP:0003398)2.65951582
25White forelock (HP:0002211)2.65319100
26Dilatation of the ascending aorta (HP:0005111)2.65208884
27Parakeratosis (HP:0001036)2.64081246
28Aortic dissection (HP:0002647)2.63473649
29Patchy hypopigmentation of hair (HP:0011365)2.62939812
30T lymphocytopenia (HP:0005403)2.61687772
31Absent frontal sinuses (HP:0002688)2.60276163
32Prostate neoplasm (HP:0100787)2.59724201
33Ectropion (HP:0000656)2.57031911
34Glucose intolerance (HP:0000833)2.55989458
35Abnormality of T cell number (HP:0011839)2.55694907
36Short middle phalanx of the 5th finger (HP:0004220)2.55298944
37Increased density of long bones (HP:0006392)2.54683329
38Abnormality of the frontal sinuses (HP:0002687)2.51535459
39Generalized hypopigmentation (HP:0007513)2.46358924
40Fetal akinesia sequence (HP:0001989)2.46216146
41Abnormality of the fingertips (HP:0001211)2.40351220
42Freckling (HP:0001480)2.39222818
43Soft skin (HP:0000977)2.38482297
44Hypoplasia of the fovea (HP:0007750)2.33865213
45Aplasia/Hypoplasia of the fovea (HP:0008060)2.33865213
46Pustule (HP:0200039)2.33188303
47Metaphyseal dysplasia (HP:0100255)2.31719188
48Hamartoma of the eye (HP:0010568)2.29541409
49Wrist flexion contracture (HP:0001239)2.29255074
50Aplasia/Hypoplasia of the macula (HP:0008059)2.28839713
51Hypokinesia (HP:0002375)2.27960834
52Genu recurvatum (HP:0002816)2.26994447
53Abnormal auditory evoked potentials (HP:0006958)2.26896046
54Thick nail (HP:0001805)2.25178754
55Hydroxyprolinuria (HP:0003080)2.25055613
56Abnormality of proline metabolism (HP:0010907)2.25055613
57Erythema (HP:0010783)2.22523092
58Nasal polyposis (HP:0100582)2.21360379
59Increased IgE level (HP:0003212)2.19419140
60Corneal dystrophy (HP:0001131)2.19079028
61Vascular calcification (HP:0004934)2.18054701
62Arterial tortuosity (HP:0005116)2.17166910
63Abnormalities of placenta or umbilical cord (HP:0001194)2.16515545
64Malignant hyperthermia (HP:0002047)2.15868945
65Spondylolisthesis (HP:0003302)2.14536912
66Iris hypopigmentation (HP:0007730)2.13866747
67Dislocated radial head (HP:0003083)2.13165578
68Mitral stenosis (HP:0001718)2.12009066
69Entropion (HP:0000621)2.10974318
70Cystic hygroma (HP:0000476)2.10689272
71Sparse eyelashes (HP:0000653)2.09595761
72Sensory axonal neuropathy (HP:0003390)2.07623189
73Encephalitis (HP:0002383)2.07455940
74Aplasia/Hypoplasia affecting the retina (HP:0008061)2.06861729
75Stillbirth (HP:0003826)2.06472120
76Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.04798786
77Cervical subluxation (HP:0003308)2.03414747
78Thin ribs (HP:0000883)2.03100725
79Vascular tortuosity (HP:0004948)2.02510722
80Blepharitis (HP:0000498)2.02343477
81Abnormality of the umbilical cord (HP:0010881)2.01837078
82Ankle contracture (HP:0006466)2.01169285
83Curly hair (HP:0002212)2.00985986
84Abnormal glucose tolerance (HP:0001952)2.00293786
85Abnormality of the fovea (HP:0000493)2.00192996
86Distal lower limb amyotrophy (HP:0008944)2.00031005
87Vertebral compression fractures (HP:0002953)1.98917757
88Short nail (HP:0001799)1.98711345
89Abnormal hair whorl (HP:0010721)1.98390320
90Erythroderma (HP:0001019)1.97161068
91Aplasia/Hypoplasia of the scapulae (HP:0006713)1.96884414
92Hypoplastic scapulae (HP:0000882)1.96884414
93Palmoplantar hyperkeratosis (HP:0000972)1.96681722
94Pterygium (HP:0001059)1.96339670
95Asymmetry of the thorax (HP:0001555)1.95650647
96Conjunctival hamartoma (HP:0100780)1.95017298
97Abnormality of the radial head (HP:0003995)1.94800714
98Palmar hyperkeratosis (HP:0010765)1.94263173
99Posterior subcapsular cataract (HP:0007787)1.93429262
100Acute myeloid leukemia (HP:0004808)1.93311038
101Autoamputation (HP:0001218)1.92721939
102Abnormal platelet volume (HP:0011876)1.92495185
103Eczematoid dermatitis (HP:0000976)1.92009965
104Intrahepatic cholestasis (HP:0001406)1.91025354
105Dyschromatopsia (HP:0007641)1.90824420
106Reduced subcutaneous adipose tissue (HP:0003758)1.89926009
107Long clavicles (HP:0000890)1.89331607
108Depressed nasal tip (HP:0000437)1.89072255
109Pelvic girdle muscle weakness (HP:0003749)1.89011001
110Thin bony cortex (HP:0002753)1.88000782
111Subacute progressive viral hepatitis (HP:0006572)1.87336253
112Increased mean platelet volume (HP:0011877)1.86396833
113Hyporeflexia of lower limbs (HP:0002600)1.85595789
114Popliteal pterygium (HP:0009756)1.85553990
115Lower limb amyotrophy (HP:0007210)1.84742617
116Cerebral aneurysm (HP:0004944)1.84421028
117Hypopigmentation of the fundus (HP:0007894)1.83341793
118Deep philtrum (HP:0002002)1.83247148
119Increased number of teeth (HP:0011069)1.82961634
120Hemiplegia (HP:0002301)1.82775295
121Delayed closure of the anterior fontanelle (HP:0001476)1.79413977
122Shallow orbits (HP:0000586)1.79143152
123Thyroiditis (HP:0100646)1.79072548
124Mitral valve prolapse (HP:0001634)1.79063319
125Retrobulbar optic neuritis (HP:0100654)1.77535185
126Optic neuritis (HP:0100653)1.77535185
127Myocardial infarction (HP:0001658)1.77400878
128Bell-shaped thorax (HP:0001591)1.76909858
129Broad palm (HP:0001169)1.74229911
130Long eyelashes (HP:0000527)1.73542998
131Delayed gross motor development (HP:0002194)1.73059031
132Facial hemangioma (HP:0000329)1.71146601
133Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.70560671
134Lip pit (HP:0100267)1.70514364
135Prolonged bleeding time (HP:0003010)1.70187087
136Autoimmune thrombocytopenia (HP:0001973)1.69688262
137Atonic seizures (HP:0010819)1.69646185
138Severe combined immunodeficiency (HP:0004430)1.69239778
139Melanoma (HP:0002861)1.68766593
140Cone-rod dystrophy (HP:0000548)1.68203716
141Cutaneous melanoma (HP:0012056)1.67149470
142Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.66788594
143Alopecia of scalp (HP:0002293)1.66352382
144Abnormality of the nasal mucosa (HP:0000433)1.66350506
145Abnormality of eosinophils (HP:0001879)1.65876268
146Difficulty climbing stairs (HP:0003551)1.65853563
147Vacuolated lymphocytes (HP:0001922)1.65204884
148Volvulus (HP:0002580)1.64002866
149Camptodactyly of toe (HP:0001836)1.63117827
150Wormian bones (HP:0002645)1.62824529
151Myositis (HP:0100614)1.62732167
152Easy fatigability (HP:0003388)1.62670046
153IgG deficiency (HP:0004315)1.62581096
154Hypoproteinemia (HP:0003075)1.61918568
155Tetraplegia (HP:0002445)1.61080664
156Eosinophilia (HP:0001880)1.60683085
157Narrow palate (HP:0000189)1.60418220
158Abnormality of the musculature of the pelvis (HP:0001469)1.60385112
159Abnormality of the hip-girdle musculature (HP:0001445)1.60385112
160Decreased muscle mass (HP:0003199)1.60367132
161Shoulder girdle muscle weakness (HP:0003547)1.60215084
162Areflexia of lower limbs (HP:0002522)1.59894769
163Birth length less than 3rd percentile (HP:0003561)1.59293344
164Deviation of the thumb (HP:0009603)1.59198509
165Persistence of primary teeth (HP:0006335)1.58241697
166Nasal speech (HP:0001611)1.58211563
167Leukocytosis (HP:0001974)1.57607323
168Recurrent fungal infections (HP:0002841)1.57448553
169Bilateral sensorineural hearing impairment (HP:0008619)1.56245157
170Aqueductal stenosis (HP:0002410)1.56177190
171Recurrent viral infections (HP:0004429)1.55684920
172Thoracolumbar scoliosis (HP:0002944)1.55303609
173Abnormal platelet function (HP:0011869)1.55028793
174Impaired platelet aggregation (HP:0003540)1.55028793
175Arterial thrombosis (HP:0004420)1.51576764

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.70206459
2NEK13.36050310
3EIF2AK33.30335853
4EPHA22.75555152
5MAP3K122.34271176
6MYLK2.30002410
7TRIM282.25447824
8STK102.21049786
9JAK32.17790065
10MAP4K12.11380049
11LATS22.01942293
12STK241.96546277
13JAK11.95854559
14LATS11.88523463
15FGFR31.86000066
16STK31.85939131
17BCR1.82433919
18MST41.78983668
19MAP3K101.67248911
20FRK1.65558600
21PLK21.64856787
22MOS1.58888835
23STK38L1.58776068
24MST1R1.58155871
25MET1.57115111
26MAP3K31.56718383
27STK391.53209032
28CDK121.51630783
29ITK1.51501928
30MUSK1.50710653
31NUAK11.46401965
32LIMK11.46259841
33MARK31.44375833
34PIM11.44143591
35PBK1.43738243
36PAK41.41088036
37FER1.40946402
38MAP3K141.39604268
39RIPK41.37575014
40PTK21.32865636
41ERBB41.32361529
42TSSK61.31292347
43BRSK21.30073319
44ACVR1B1.28624466
45PRKCH1.27227300
46PLK31.25149870
47MKNK21.20241990
48BUB11.18508238
49ALK1.18413529
50EIF2AK11.18342537
51MAP3K21.14383985
52FLT31.14231825
53PIK3CA1.13744258
54GRK61.10525385
55SRPK11.09420030
56IRAK31.08464264
57CLK11.03261102
58PAK31.03242676
59CDC71.02174884
60BMPR1B1.01493120
61TRPM71.01372675
62NEK20.97829078
63DMPK0.95618364
64RPS6KA40.95238327
65RAF10.94486388
66EEF2K0.94373927
67SIK30.94090132
68MAP3K60.93729007
69CDK60.93723134
70PDK20.93412316
71EIF2AK20.92483495
72OXSR10.91640207
73EPHA30.90934936
74KSR20.90847341
75PRKCE0.87837809
76NEK90.86021374
77PIK3CG0.84740713
78TAOK10.82905692
79GRK70.82028234
80ZAP700.81039361
81ABL20.79343808
82MAP2K70.76985980
83FGFR10.75193839
84SCYL20.75033535
85CDK90.74486835
86RET0.74376002
87LCK0.73317921
88IKBKB0.73093200
89PAK20.71705391
90SGK20.70824935
91MELK0.70074022
92TGFBR20.68267370
93SGK30.67295857
94ERBB30.66730737
95TGFBR10.66647065
96MAP2K10.66133569
97PLK40.65315402
98PIM20.65237670
99LMTK20.63038522
100ILK0.62788530
101DDR20.62480015
102ROCK10.61707621
103CHUK0.61058333
104PTK2B0.59900864
105PRKCI0.59016296
106PDGFRB0.58801779
107ROCK20.58452714
108BRSK10.57810315
109MKNK10.56707289
110LRRK20.55312883
111ABL10.54141715
112EGFR0.54056384
113MAP3K90.53143327
114RPS6KB10.52807298
115SIK20.51751389
116TYK20.51382423
117AURKB0.50524303
118TTN0.49741925
119BMPR20.49673447
120MAP3K50.49408462
121CDK40.48959516
122FGFR40.48150819
123NME20.48120298
124ADRBK10.47945272
125NLK0.47142947
126GRK10.47103259
127IKBKE0.46886802
128CDK80.44551150
129SYK0.44141199
130AKT30.43646233
131TBK10.42869646
132BMX0.40987521
133PDGFRA0.40956195
134MAP3K80.40948558
135JAK20.40494957
136CHEK20.40350825
137MAPK100.40291154
138TEC0.39693600
139ATM0.39563818
140TTK0.39496668
141MAP3K40.38662233
142GSK3A0.38653111
143HCK0.38496792
144WEE10.38482380
145NTRK30.38476575
146BRD40.36474126
147GRK50.35999422
148PRKCQ0.35808884
149IRAK10.34136401
150MINK10.32604286
151INSR0.31086948
152NEK60.30862444
153IGF1R0.30842312
154CAMK2D0.30108127
155ADRBK20.26030089
156EPHB10.25941750
157PLK10.25812220
158PAK10.21654459

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.13853494
2Graft-versus-host disease_Homo sapiens_hsa053323.01898195
3Proteasome_Homo sapiens_hsa030502.64566062
4Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.32665744
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.28687546
6Allograft rejection_Homo sapiens_hsa053302.16681663
7* Sphingolipid metabolism_Homo sapiens_hsa006002.11846732
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.92764318
9Sulfur metabolism_Homo sapiens_hsa009201.91401705
10Legionellosis_Homo sapiens_hsa051341.81804842
11Rheumatoid arthritis_Homo sapiens_hsa053231.78604824
12Vibrio cholerae infection_Homo sapiens_hsa051101.74555102
13Antigen processing and presentation_Homo sapiens_hsa046121.70532298
14Asthma_Homo sapiens_hsa053101.68932237
15T cell receptor signaling pathway_Homo sapiens_hsa046601.59890082
16Lysosome_Homo sapiens_hsa041421.53637554
17Autoimmune thyroid disease_Homo sapiens_hsa053201.53413550
18Basal transcription factors_Homo sapiens_hsa030221.53249451
19Primary immunodeficiency_Homo sapiens_hsa053401.44459183
20Type I diabetes mellitus_Homo sapiens_hsa049401.43018836
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39116097
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.31854797
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31754454
24p53 signaling pathway_Homo sapiens_hsa041151.29296689
25Viral myocarditis_Homo sapiens_hsa054161.28657583
26Vitamin B6 metabolism_Homo sapiens_hsa007501.27518778
27Tight junction_Homo sapiens_hsa045301.23124414
28Measles_Homo sapiens_hsa051621.21118300
29Circadian rhythm_Homo sapiens_hsa047101.20817046
30Collecting duct acid secretion_Homo sapiens_hsa049661.20217850
31Cell cycle_Homo sapiens_hsa041101.17269848
32Hematopoietic cell lineage_Homo sapiens_hsa046401.17150392
33Chronic myeloid leukemia_Homo sapiens_hsa052201.16760634
34Phagosome_Homo sapiens_hsa041451.16697932
35Long-term potentiation_Homo sapiens_hsa047201.16382477
36Pancreatic cancer_Homo sapiens_hsa052121.15153409
37Osteoclast differentiation_Homo sapiens_hsa043801.14958902
38Hepatitis B_Homo sapiens_hsa051611.14483383
39Shigellosis_Homo sapiens_hsa051311.11413235
40Leishmaniasis_Homo sapiens_hsa051401.11191668
41Colorectal cancer_Homo sapiens_hsa052101.08864677
42Platelet activation_Homo sapiens_hsa046111.07192669
43Non-homologous end-joining_Homo sapiens_hsa034501.06072398
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05673048
45MicroRNAs in cancer_Homo sapiens_hsa052061.04901420
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04640352
47Hippo signaling pathway_Homo sapiens_hsa043901.03898911
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03567690
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02836989
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02809359
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02495635
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.01614871
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01114673
54Toxoplasmosis_Homo sapiens_hsa051451.00926116
55Hepatitis C_Homo sapiens_hsa051601.00410769
56B cell receptor signaling pathway_Homo sapiens_hsa046620.99950457
57mTOR signaling pathway_Homo sapiens_hsa041500.98743968
58Amoebiasis_Homo sapiens_hsa051460.98674489
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96849064
60Glioma_Homo sapiens_hsa052140.96197032
61Oocyte meiosis_Homo sapiens_hsa041140.95720170
62TNF signaling pathway_Homo sapiens_hsa046680.95317582
63Endometrial cancer_Homo sapiens_hsa052130.95027249
64FoxO signaling pathway_Homo sapiens_hsa040680.94536013
65Malaria_Homo sapiens_hsa051440.94124061
66Adherens junction_Homo sapiens_hsa045200.94080468
67Apoptosis_Homo sapiens_hsa042100.93866314
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.93777028
69Glutathione metabolism_Homo sapiens_hsa004800.93745832
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93719049
71Thyroid cancer_Homo sapiens_hsa052160.92104133
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91473721
73African trypanosomiasis_Homo sapiens_hsa051430.91349240
74Proteoglycans in cancer_Homo sapiens_hsa052050.91284899
75Salmonella infection_Homo sapiens_hsa051320.90345684
76Non-small cell lung cancer_Homo sapiens_hsa052230.90288324
77Acute myeloid leukemia_Homo sapiens_hsa052210.89744679
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89663022
79RNA transport_Homo sapiens_hsa030130.88603254
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88594340
81Prolactin signaling pathway_Homo sapiens_hsa049170.88508462
82Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87977338
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.87130004
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.86686314
85TGF-beta signaling pathway_Homo sapiens_hsa043500.85770719
86Chemokine signaling pathway_Homo sapiens_hsa040620.84800550
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.84153006
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83873729
89HTLV-I infection_Homo sapiens_hsa051660.83746821
90Focal adhesion_Homo sapiens_hsa045100.83467892
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81774377
92Renal cell carcinoma_Homo sapiens_hsa052110.81352605
93Dorso-ventral axis formation_Homo sapiens_hsa043200.81185009
94Prostate cancer_Homo sapiens_hsa052150.81032640
95Tuberculosis_Homo sapiens_hsa051520.80827801
96Epstein-Barr virus infection_Homo sapiens_hsa051690.80148088
97Bladder cancer_Homo sapiens_hsa052190.80087949
98VEGF signaling pathway_Homo sapiens_hsa043700.79284042
99MAPK signaling pathway_Homo sapiens_hsa040100.78995051
100Pertussis_Homo sapiens_hsa051330.78711995
101Small cell lung cancer_Homo sapiens_hsa052220.78340971
102ErbB signaling pathway_Homo sapiens_hsa040120.78044997
103Herpes simplex infection_Homo sapiens_hsa051680.75273648
104mRNA surveillance pathway_Homo sapiens_hsa030150.75172956
105Viral carcinogenesis_Homo sapiens_hsa052030.74698803
106N-Glycan biosynthesis_Homo sapiens_hsa005100.73399400
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72783185
108Rap1 signaling pathway_Homo sapiens_hsa040150.69965172
109RNA polymerase_Homo sapiens_hsa030200.68715818
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68497939
111Estrogen signaling pathway_Homo sapiens_hsa049150.68397706
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67886628
113Influenza A_Homo sapiens_hsa051640.67745806
114Steroid biosynthesis_Homo sapiens_hsa001000.65729101
115Other glycan degradation_Homo sapiens_hsa005110.65583890
116Endocytosis_Homo sapiens_hsa041440.65487810
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65294365
118Long-term depression_Homo sapiens_hsa047300.64618878
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.64484235
120Oxytocin signaling pathway_Homo sapiens_hsa049210.63788727
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61973140
122GnRH signaling pathway_Homo sapiens_hsa049120.61763310
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61673385
124ECM-receptor interaction_Homo sapiens_hsa045120.60933858
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59954480
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59737170
127Choline metabolism in cancer_Homo sapiens_hsa052310.59572300
128Melanoma_Homo sapiens_hsa052180.59373703
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59284575
130Staphylococcus aureus infection_Homo sapiens_hsa051500.59114885
131Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58499770
132Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57405044
133Amphetamine addiction_Homo sapiens_hsa050310.57350054
134Selenocompound metabolism_Homo sapiens_hsa004500.57211866
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56632936
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56489387
137RNA degradation_Homo sapiens_hsa030180.54517060
138Mineral absorption_Homo sapiens_hsa049780.54204830
139RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53876410
140Salivary secretion_Homo sapiens_hsa049700.53773878
141Gap junction_Homo sapiens_hsa045400.53175387
142Dopaminergic synapse_Homo sapiens_hsa047280.52994294
143Ether lipid metabolism_Homo sapiens_hsa005650.49646865
144Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48031237
145Pathways in cancer_Homo sapiens_hsa052000.47547089
146Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45993679
147Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44430873
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39661267

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »