UCMA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a chondrocyte-specific, highly charged protein that is abundantly expressed in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the encoded protein is associated with osteoarthritis in humans. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of extracellular matrix organization (GO:1903055)8.71913712
2negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)8.63046807
3cartilage development involved in endochondral bone morphogenesis (GO:0060351)8.46138944
4notochord development (GO:0030903)8.39258792
5limb bud formation (GO:0060174)7.99650900
6cell aggregation (GO:0098743)7.98395185
7cartilage condensation (GO:0001502)7.98395185
8axoneme assembly (GO:0035082)7.39868144
9cilium movement (GO:0003341)6.82935920
10regulation of DNA methylation (GO:0044030)6.64632207
11chondrocyte development (GO:0002063)6.56418596
12CENP-A containing nucleosome assembly (GO:0034080)5.92379254
13chromatin remodeling at centromere (GO:0031055)5.90042340
14GTP biosynthetic process (GO:0006183)5.86866704
15nucleoside diphosphate phosphorylation (GO:0006165)5.81763828
16cilium or flagellum-dependent cell motility (GO:0001539)5.65918911
17regulation of extracellular matrix disassembly (GO:0010715)5.65547780
18regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)5.38569060
19regulation of mitotic spindle checkpoint (GO:1903504)5.38569060
20regulation of extracellular matrix organization (GO:1903053)5.33855843
21UTP biosynthetic process (GO:0006228)5.30019893
22endothelial cell morphogenesis (GO:0001886)5.27447837
23regulation of plasminogen activation (GO:0010755)5.18585728
24regulation of meiosis I (GO:0060631)5.03458189
25cellular glucuronidation (GO:0052695)5.01283858
26ventricular system development (GO:0021591)4.99660985
27heart valve formation (GO:0003188)4.95508877
28histone exchange (GO:0043486)4.87568786
29UTP metabolic process (GO:0046051)4.86875729
30keratan sulfate catabolic process (GO:0042340)4.83696078
31DNA replication-independent nucleosome organization (GO:0034724)4.76673333
32DNA replication-independent nucleosome assembly (GO:0006336)4.76673333
33chaperone-mediated protein transport (GO:0072321)4.76138896
34regulation of histone H3-K9 methylation (GO:0051570)4.76055876
35embryonic skeletal joint morphogenesis (GO:0060272)4.74749862
36collagen fibril organization (GO:0030199)4.73536453
37endocardial cushion morphogenesis (GO:0003203)4.73260665
38mitotic metaphase plate congression (GO:0007080)4.72882989
39epithelial cilium movement (GO:0003351)4.72486631
40DNA replication checkpoint (GO:0000076)4.64575108
41protein localization to kinetochore (GO:0034501)4.58218367
42otic vesicle formation (GO:0030916)4.53559912
43iron ion import (GO:0097286)4.50026142
44uronic acid metabolic process (GO:0006063)4.40543950
45glucuronate metabolic process (GO:0019585)4.40543950
46axonemal dynein complex assembly (GO:0070286)4.35434769
47cartilage development (GO:0051216)4.29210495
48meiotic cell cycle (GO:0051321)4.25512703
49mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.23029334
50regulation of female gonad development (GO:2000194)4.16992959
51regulation of spindle checkpoint (GO:0090231)4.15094578
52positive regulation of histone H3-K4 methylation (GO:0051571)4.08157257
53negative regulation of histone methylation (GO:0031061)4.05325619
54protein localization to chromosome, centromeric region (GO:0071459)4.05164771
55termination of RNA polymerase III transcription (GO:0006386)4.01652837
56transcription elongation from RNA polymerase III promoter (GO:0006385)4.01652837
57proteasome assembly (GO:0043248)4.00938492
58chondrocyte differentiation (GO:0002062)3.99082210
59establishment of integrated proviral latency (GO:0075713)3.93937805
60metaphase plate congression (GO:0051310)3.87022831
61regulation of mesenchymal cell apoptotic process (GO:2001053)3.85977433
62mesenchyme morphogenesis (GO:0072132)3.84967522
63proteoglycan metabolic process (GO:0006029)3.84725737
64regulation of helicase activity (GO:0051095)3.84199750
65photoreceptor cell differentiation (GO:0046530)3.83754462
66eye photoreceptor cell differentiation (GO:0001754)3.83754462
67establishment of protein localization to mitochondrial membrane (GO:0090151)3.83244980
68positive regulation of chondrocyte differentiation (GO:0032332)3.83189960
69negative regulation of mitotic sister chromatid segregation (GO:0033048)3.82745843
70negative regulation of mitotic sister chromatid separation (GO:2000816)3.82745843
71negative regulation of sister chromatid segregation (GO:0033046)3.82745843
72negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.82745843
73negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.82745843
74microtubule bundle formation (GO:0001578)3.80777463
75negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.79598838
76positive regulation of chromosome segregation (GO:0051984)3.79141306
77negative regulation of chromosome segregation (GO:0051985)3.76663651
78retinal cone cell development (GO:0046549)3.76546729
79female gamete generation (GO:0007292)3.75024237
80establishment of chromosome localization (GO:0051303)3.72532863
81regulation of mitotic metaphase/anaphase transition (GO:0030071)3.71996297
82regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.71996297
83keratan sulfate biosynthetic process (GO:0018146)3.69791760
84synapsis (GO:0007129)3.67072868
85guanosine-containing compound biosynthetic process (GO:1901070)3.66043059
86piRNA metabolic process (GO:0034587)3.65940562
87regulation of sister chromatid segregation (GO:0033045)3.65671500
88regulation of mitotic sister chromatid separation (GO:0010965)3.65671500
89regulation of mitotic sister chromatid segregation (GO:0033047)3.65671500
90mitotic chromosome condensation (GO:0007076)3.61336572
91telomere maintenance via semi-conservative replication (GO:0032201)3.60710721
92DNA strand elongation involved in DNA replication (GO:0006271)3.60590181
93kinetochore organization (GO:0051383)3.57138631
94regulation of acrosome reaction (GO:0060046)3.56604257
95CTP biosynthetic process (GO:0006241)3.55143742
96CTP metabolic process (GO:0046036)3.55143742
97regulation of mitochondrial translation (GO:0070129)3.54007329
98nephron tubule formation (GO:0072079)3.53215255
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.51422253
100chondroitin sulfate biosynthetic process (GO:0030206)3.48152990
101DNA replication-dependent nucleosome assembly (GO:0006335)3.47067808
102DNA replication-dependent nucleosome organization (GO:0034723)3.47067808
103spindle checkpoint (GO:0031577)3.46881090
104chromatin assembly or disassembly (GO:0006333)3.46235935
105DNA strand elongation (GO:0022616)3.44695799
106histone mRNA metabolic process (GO:0008334)3.41469361
107central nervous system myelination (GO:0022010)3.39879362
108axon ensheathment in central nervous system (GO:0032291)3.39879362
109spliceosomal snRNP assembly (GO:0000387)3.39558835
110telomere maintenance via telomerase (GO:0007004)3.39474796
111nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.36804564
112collagen catabolic process (GO:0030574)3.34912562
113negative regulation of mitosis (GO:0045839)3.33576018
114regulation of integrin-mediated signaling pathway (GO:2001044)3.33188641
115kinetochore assembly (GO:0051382)3.32958459
116negative regulation of DNA-dependent DNA replication (GO:2000104)3.31693790
117regulation of chromosome segregation (GO:0051983)3.29916541
118pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.28904278
119mitotic spindle checkpoint (GO:0071174)3.28672075
120regulation of heart morphogenesis (GO:2000826)3.28022909
121energy coupled proton transport, down electrochemical gradient (GO:0015985)3.26271363
122ATP synthesis coupled proton transport (GO:0015986)3.26271363
123anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.23783649
124peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.22285360
125collagen metabolic process (GO:0032963)3.18499221
126skeletal system development (GO:0001501)3.16571478
127regulation of double-strand break repair via homologous recombination (GO:0010569)3.16478961
128centriole replication (GO:0007099)3.15435169
129mitotic spindle assembly checkpoint (GO:0007094)3.15186031
130mitotic G2/M transition checkpoint (GO:0044818)3.14032543
131peptidyl-proline hydroxylation (GO:0019511)3.12207614
132neural crest cell development (GO:0014032)3.09451921
133pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.09115881
134telomere maintenance via telomere lengthening (GO:0010833)3.08448268
135positive regulation of mitotic sister chromatid separation (GO:1901970)3.08151154
136positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.08151154
137positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.08151154
138spindle assembly checkpoint (GO:0071173)3.07590803
139telomere maintenance via recombination (GO:0000722)3.07529532
140mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.07015083
141lymph vessel development (GO:0001945)3.05910826
142positive regulation of cartilage development (GO:0061036)3.05577163
143attachment of spindle microtubules to kinetochore (GO:0008608)3.05157375
144multicellular organismal catabolic process (GO:0044243)3.03423666
145negative regulation of nuclear division (GO:0051784)3.03191343
146oligodendrocyte differentiation (GO:0048709)3.03157781
147positive regulation of male gonad development (GO:2000020)3.02964298
148negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.01699949
149nucleotide-sugar biosynthetic process (GO:0009226)3.01683174
150multicellular organism reproduction (GO:0032504)2.99733666
151multicellular organismal macromolecule metabolic process (GO:0044259)2.97261789
152respiratory electron transport chain (GO:0022904)2.96557474
153rRNA modification (GO:0000154)2.96020596
154regulation of nuclear cell cycle DNA replication (GO:0033262)2.95487252
155glycosaminoglycan biosynthetic process (GO:0006024)2.94728762
156positive regulation of histone methylation (GO:0031062)2.94219843
157protein neddylation (GO:0045116)2.93367962
158regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.92913924
159regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92085057
160DNA methylation involved in gamete generation (GO:0043046)2.91511905
161protein retention in ER lumen (GO:0006621)2.91398385
162paraxial mesoderm development (GO:0048339)2.91261691
163establishment of viral latency (GO:0019043)2.90459714
164keratan sulfate metabolic process (GO:0042339)2.90324928
165negative regulation of endothelial cell proliferation (GO:0001937)2.90005780
166ATP-dependent chromatin remodeling (GO:0043044)2.89436571
167nucleotide phosphorylation (GO:0046939)2.88845768
168aminoglycan biosynthetic process (GO:0006023)2.88193106
169electron transport chain (GO:0022900)2.86860185
170muscle organ morphogenesis (GO:0048644)2.85274679
171negative regulation of inclusion body assembly (GO:0090084)2.84175628
172purine nucleobase biosynthetic process (GO:0009113)2.83628683
173regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.83511841
174left/right axis specification (GO:0070986)2.83212276
175maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.82382931
176regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.82218309
177regulation of male gonad development (GO:2000018)2.81184633
178nuclear pore organization (GO:0006999)2.81171548
179heart valve morphogenesis (GO:0003179)2.80925438
180chondroitin sulfate metabolic process (GO:0030204)2.80745445
181response to gravity (GO:0009629)2.80406758
182negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.80204046
183multicellular organismal metabolic process (GO:0044236)2.79483354
184negative regulation of chondrocyte differentiation (GO:0032331)2.79394199
185cardiac epithelial to mesenchymal transition (GO:0060317)2.76833254
186regulation of mononuclear cell migration (GO:0071675)2.74582598
187male sex determination (GO:0030238)2.73832612
188extracellular matrix disassembly (GO:0022617)2.69465150
189replacement ossification (GO:0036075)2.67943364
190endochondral ossification (GO:0001958)2.67943364
191response to pheromone (GO:0019236)2.66615624
192regulation of chondrocyte differentiation (GO:0032330)2.62851730
193one-carbon compound transport (GO:0019755)2.62500940
194mesenchymal cell development (GO:0014031)2.58527945
195regulation of glucose import in response to insulin stimulus (GO:2001273)2.57086124
196response to BMP (GO:0071772)2.55543839
197cellular response to BMP stimulus (GO:0071773)2.55543839
198response to follicle-stimulating hormone (GO:0032354)2.53858918
199negative regulation of cartilage development (GO:0061037)2.53412884
200glycosphingolipid catabolic process (GO:0046479)2.53143908

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.35693537
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.58620374
3EZH2_22144423_ChIP-Seq_EOC_Human5.47430192
4TRIM28_21343339_ChIP-Seq_HEK293_Human4.85798012
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.15121613
6AR_21572438_ChIP-Seq_LNCaP_Human3.85224533
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.61966360
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.60594378
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.52121520
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.44586647
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.44586647
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.44586647
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.23043154
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.18674327
15EST1_17652178_ChIP-ChIP_JURKAT_Human3.16908441
16MYC_18555785_ChIP-Seq_MESCs_Mouse3.11001552
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.98227730
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.79616772
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.76450368
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63274484
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.45031491
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33811384
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.24316557
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.21965395
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.21121636
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.17512902
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17320319
28JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16766669
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.15261560
30EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13575447
31RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13575447
32JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08557245
33ELK1_19687146_ChIP-ChIP_HELA_Human2.02114525
34EED_16625203_ChIP-ChIP_MESCs_Mouse2.01902893
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.98879175
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.98816907
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.98068157
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.95938699
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92975124
40FOXP3_21729870_ChIP-Seq_TREG_Human1.89438306
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84989809
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83043120
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.81908574
44TP53_18474530_ChIP-ChIP_U2OS_Human1.80118760
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77011134
46AR_21909140_ChIP-Seq_LNCAP_Human1.76336401
47CJUN_26792858_Chip-Seq_BT549_Human1.75519505
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70856759
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70168684
50MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68125064
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66399821
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.66257357
53EWS_26573619_Chip-Seq_HEK293_Human1.63613498
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63316139
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.62774977
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.62137633
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60055478
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.59727225
59MYC_18940864_ChIP-ChIP_HL60_Human1.59511811
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.57503035
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.56184730
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.56092165
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54961937
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53587270
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.53405978
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.52897368
67TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.51163897
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.50496322
69SMAD4_21799915_ChIP-Seq_A2780_Human1.49795171
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49002091
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48595608
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48032679
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.46647548
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46497139
75VDR_23849224_ChIP-Seq_CD4+_Human1.46407034
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.46247900
77GBX2_23144817_ChIP-Seq_PC3_Human1.46070092
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.45639981
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.44881273
80* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43641291
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42718820
82NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.42454771
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.42454771
84E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42292297
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.41895037
86P53_22127205_ChIP-Seq_FIBROBLAST_Human1.41411577
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40747659
88EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.39758403
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38203198
90P300_19829295_ChIP-Seq_ESCs_Human1.37997900
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36421557
92NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33123433
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33081538
94SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32462635
95GATA1_26923725_Chip-Seq_HPCs_Mouse1.31992742
96ER_23166858_ChIP-Seq_MCF-7_Human1.31902397
97RXR_22108803_ChIP-Seq_LS180_Human1.31790892
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31618734
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31477340
100EZH2_27294783_Chip-Seq_ESCs_Mouse1.31191284
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30699528
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30699528
103FOXM1_26456572_ChIP-Seq_MCF-7_Human1.30538843
104RING1B_27294783_Chip-Seq_ESCs_Mouse1.30338130
105TTF2_22483619_ChIP-Seq_HELA_Human1.29525332
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29341212
107BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29005806
108POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28959064
109MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28179001
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28075453
111GATA1_22025678_ChIP-Seq_K562_Human1.27278266
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26532787
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25555874
114PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25480887
115ESR1_21235772_ChIP-Seq_MCF-7_Human1.25384214
116CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25382157
117PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25190623
118SOX2_20726797_ChIP-Seq_SW620_Human1.24136508
119SOX2_16153702_ChIP-ChIP_HESCs_Human1.23201240
120FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22879488
121TP63_19390658_ChIP-ChIP_HaCaT_Human1.22226207
122MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22219834
123FUS_26573619_Chip-Seq_HEK293_Human1.21608626
124ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21495608
125PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21073352
126SALL1_21062744_ChIP-ChIP_HESCs_Human1.19501846
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19358317
128TP53_20018659_ChIP-ChIP_R1E_Mouse1.18990402
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18948676
130CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18128321
131SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14998199
132SMAD3_21741376_ChIP-Seq_EPCs_Human1.14969979
133NANOG_18555785_Chip-Seq_ESCs_Mouse1.14947386
134PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12908466
135DCP1A_22483619_ChIP-Seq_HELA_Human1.10619542
136RING1B_27294783_Chip-Seq_NPCs_Mouse1.10544248
137BCAT_22108803_ChIP-Seq_LS180_Human1.10293388
138E2F1_18555785_Chip-Seq_ESCs_Mouse1.10156162
139HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09327675
140ARNT_22903824_ChIP-Seq_MCF-7_Human1.04875661
141TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04810597
142LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04476233
143NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04134136
144VDR_24787735_ChIP-Seq_THP-1_Human1.03612622
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02758025
146UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02680774
147ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02284475
148POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00751166
149TCF4_22108803_ChIP-Seq_LS180_Human1.00612679
150VDR_22108803_ChIP-Seq_LS180_Human0.99957890
151FLI1_27457419_Chip-Seq_LIVER_Mouse0.99653415
152EP300_21415370_ChIP-Seq_HL-1_Mouse0.99625431
153NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99505901
154SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98494392
155RUNX2_22187159_ChIP-Seq_PCA_Human0.98443352
156NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.98033721
157WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97832502
158TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97176957
159PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97053143
160AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96450848
161PRDM14_20953172_ChIP-Seq_ESCs_Human0.96269449
162PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94411184
163TAF15_26573619_Chip-Seq_HEK293_Human0.94353442
164DROSHA_22980978_ChIP-Seq_HELA_Human0.93621411
165JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93373121
166* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92950909
167XRN2_22483619_ChIP-Seq_HELA_Human0.92837893
168P53_22387025_ChIP-Seq_ESCs_Mouse0.91754655
169NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91558194
170TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91333272
171EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91314723
172SRF_21415370_ChIP-Seq_HL-1_Mouse0.91314621
173TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91078003
174IRF1_19129219_ChIP-ChIP_H3396_Human0.90895996
175IGF1R_20145208_ChIP-Seq_DFB_Human0.90316577
176HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90038837
177AR_25329375_ChIP-Seq_VCAP_Human0.89855693
178SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86612847
179GABP_19822575_ChIP-Seq_HepG2_Human0.83678680
180ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.83085001
181ELK1_22589737_ChIP-Seq_MCF10A_Human0.78488119
182ZNF274_21170338_ChIP-Seq_K562_Hela0.77907597
183E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77828526
184HTT_18923047_ChIP-ChIP_STHdh_Human0.71707961
185CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.70419448
186BP1_19119308_ChIP-ChIP_Hs578T_Human0.69796949
187TBX3_20139965_ChIP-Seq_ESCs_Mouse0.68878151
188TBX3_20139965_ChIP-Seq_MESCs_Mouse0.67573482
189NANOG_20526341_ChIP-Seq_ESCs_Human0.66973184
190ESR1_15608294_ChIP-ChIP_MCF-7_Human0.66296804

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect6.30826326
2MP0006292_abnormal_olfactory_placode5.50527114
3MP0004134_abnormal_chest_morphology4.96247442
4MP0002282_abnormal_trachea_morphology4.65767557
5MP0008877_abnormal_DNA_methylation4.34682614
6MP0003941_abnormal_skin_development4.29309301
7MP0002933_joint_inflammation4.00456584
8MP0003693_abnormal_embryo_hatching3.82619845
9MP0009250_abnormal_appendicular_skeleto3.48327691
10MP0003950_abnormal_plasma_membrane3.32525197
11MP0005503_abnormal_tendon_morphology3.13562353
12MP0003195_calcinosis3.08876948
13MP0010094_abnormal_chromosome_stability3.06650641
14MP0000163_abnormal_cartilage_morphology3.05103201
15MP0002249_abnormal_larynx_morphology3.04062305
16MP0003890_abnormal_embryonic-extraembry3.00482633
17MP0003111_abnormal_nucleus_morphology2.98673438
18MP0004957_abnormal_blastocyst_morpholog2.89275490
19MP0005623_abnormal_meninges_morphology2.84729160
20MP0008058_abnormal_DNA_repair2.80363362
21MP0003077_abnormal_cell_cycle2.77186401
22MP0008789_abnormal_olfactory_epithelium2.59439929
23MP0002896_abnormal_bone_mineralization2.50571018
24MP0002115_abnormal_skeleton_extremities2.49827749
25MP0008057_abnormal_DNA_replication2.48265650
26MP0001293_anophthalmia2.45412933
27MP0003283_abnormal_digestive_organ2.39374368
28MP0010030_abnormal_orbit_morphology2.36776077
29MP0002089_abnormal_postnatal_growth/wei2.33552288
30MP0003279_aneurysm2.27371756
31MP0001299_abnormal_eye_distance/2.26908412
32MP0000049_abnormal_middle_ear2.24477151
33MP0005395_other_phenotype2.23346709
34MP0001346_abnormal_lacrimal_gland2.21219897
35MP0009780_abnormal_chondrocyte_physiolo2.15910078
36MP0005499_abnormal_olfactory_system2.08300489
37MP0005394_taste/olfaction_phenotype2.08300489
38MP0003705_abnormal_hypodermis_morpholog2.08258445
39MP0000762_abnormal_tongue_morphology2.06712444
40MP0008932_abnormal_embryonic_tissue2.04309308
41MP0002113_abnormal_skeleton_development2.02327459
42MP0005508_abnormal_skeleton_morphology1.78321628
43MP0003646_muscle_fatigue1.71764025
44MP0001533_abnormal_skeleton_physiology1.70950993
45MP0004272_abnormal_basement_membrane1.70947035
46MP0002109_abnormal_limb_morphology1.67365358
47MP0002210_abnormal_sex_determination1.66775526
48MP0008438_abnormal_cutaneous_collagen1.66434395
49MP0005646_abnormal_pituitary_gland1.66262121
50MP0003937_abnormal_limbs/digits/tail_de1.65062351
51MP0002233_abnormal_nose_morphology1.64714124
52MP0005390_skeleton_phenotype1.61975364
53MP0001188_hyperpigmentation1.61515532
54MP0003121_genomic_imprinting1.61008128
55MP0003699_abnormal_female_reproductive1.59915358
56MP0003755_abnormal_palate_morphology1.57555872
57MP0001929_abnormal_gametogenesis1.55878486
58MP0000428_abnormal_craniofacial_morphol1.53056391
59MP0004885_abnormal_endolymph1.51986143
60MP0002116_abnormal_craniofacial_bone1.48288064
61MP0001984_abnormal_olfaction1.48260263
62MP0001270_distended_abdomen1.47999223
63MP0001730_embryonic_growth_arrest1.47734560
64MP0008007_abnormal_cellular_replicative1.46455736
65MP0002108_abnormal_muscle_morphology1.44639620
66MP0000350_abnormal_cell_proliferation1.43172666
67MP0005023_abnormal_wound_healing1.42260363
68MP0001963_abnormal_hearing_physiology1.38697734
69MP0002876_abnormal_thyroid_physiology1.38327040
70MP0009384_cardiac_valve_regurgitation1.37542945
71MP0000653_abnormal_sex_gland1.37214916
72MP0002138_abnormal_hepatobiliary_system1.36089764
73MP0002139_abnormal_hepatobiliary_system1.35528237
74MP0002277_abnormal_respiratory_mucosa1.35290044
75MP0003795_abnormal_bone_structure1.32640328
76MP0003567_abnormal_fetal_cardiomyocyte1.28746788
77MP0001145_abnormal_male_reproductive1.28720771
78MP0003122_maternal_imprinting1.26522840
79MP0002909_abnormal_adrenal_gland1.26058777
80MP0002254_reproductive_system_inflammat1.24658280
81MP0003786_premature_aging1.22430053
82MP0005275_abnormal_skin_tensile1.22132553
83MP0002998_abnormal_bone_remodeling1.20755014
84MP0004859_abnormal_synaptic_plasticity1.20354424
85MP0002161_abnormal_fertility/fecundity1.18069830
86MP0000778_abnormal_nervous_system1.15762207
87MP0002796_impaired_skin_barrier1.12791370
88MP0003091_abnormal_cell_migration1.10296256
89MP0001286_abnormal_eye_development1.10089811
90MP0001958_emphysema1.08844945
91MP0000631_abnormal_neuroendocrine_gland1.08383821
92MP0005380_embryogenesis_phenotype1.05572428
93MP0001672_abnormal_embryogenesis/_devel1.05572428
94MP0002396_abnormal_hematopoietic_system1.05360042
95MP0005410_abnormal_fertilization1.04051232
96MP0003690_abnormal_glial_cell1.03638821
97MP0003119_abnormal_digestive_system1.03154730
98MP0000432_abnormal_head_morphology1.02991325
99MP0002697_abnormal_eye_size1.02631607
100MP0002085_abnormal_embryonic_tissue1.01952953
101MP0005381_digestive/alimentary_phenotyp1.01851476
102MP0005389_reproductive_system_phenotype1.01674759
103MP0001119_abnormal_female_reproductive1.01406161
104MP0008995_early_reproductive_senescence0.99843593
105MP0000751_myopathy0.99556850
106MP0002735_abnormal_chemical_nociception0.98166439
107MP0003186_abnormal_redox_activity0.96933612
108MP0001697_abnormal_embryo_size0.96630467
109MP0010368_abnormal_lymphatic_system0.96349442
110MP0009672_abnormal_birth_weight0.96134525
111MP0006072_abnormal_retinal_apoptosis0.95996376
112MP0006035_abnormal_mitochondrial_morpho0.95776555
113MP0001663_abnormal_digestive_system0.94742925
114MP0000026_abnormal_inner_ear0.94691478
115MP0003879_abnormal_hair_cell0.93761375
116MP0002160_abnormal_reproductive_system0.92698116
117MP0010307_abnormal_tumor_latency0.92600714
118MP0003698_abnormal_male_reproductive0.91875798
119MP0002090_abnormal_vision0.89209912
120MP0002064_seizures0.88933949
121MP0005360_urolithiasis0.88555156
122MP0001177_atelectasis0.88393519
123MP0002084_abnormal_developmental_patter0.88064570
124MP0002234_abnormal_pharynx_morphology0.85911080
125MP0000462_abnormal_digestive_system0.85117662
126MP0001879_abnormal_lymphatic_vessel0.83317829
127MP0002111_abnormal_tail_morphology0.82769132
128MP0001348_abnormal_lacrimal_gland0.82397728
129MP0002938_white_spotting0.82289966
130MP0002114_abnormal_axial_skeleton0.80465809
131MP0005167_abnormal_blood-brain_barrier0.79891074
132MP0002932_abnormal_joint_morphology0.79638082
133MP0004019_abnormal_vitamin_homeostasis0.79288794
134MP0003136_yellow_coat_color0.78750622
135MP0006138_congestive_heart_failure0.78726307
136MP0005551_abnormal_eye_electrophysiolog0.77597837
137MP0001485_abnormal_pinna_reflex0.77209868
138MP0002063_abnormal_learning/memory/cond0.76760549
139MP0000534_abnormal_ureter_morphology0.76546924
140MP0003880_abnormal_central_pattern0.76515516
141MP0009379_abnormal_foot_pigmentation0.76444854
142MP0003635_abnormal_synaptic_transmissio0.75722949
143MP0003942_abnormal_urinary_system0.75209678
144MP0009046_muscle_twitch0.74418466
145MP0004142_abnormal_muscle_tone0.74271063
146MP0005647_abnormal_sex_gland0.74185298
147MP0001324_abnormal_eye_pigmentation0.73727254
148MP0003566_abnormal_cell_adhesion0.72321616
149MP0003935_abnormal_craniofacial_develop0.71099182
150MP0000313_abnormal_cell_death0.70705333
151MP0001542_abnormal_bone_strength0.70230148
152MP0001919_abnormal_reproductive_system0.70164482
153MP0002080_prenatal_lethality0.69692759
154MP0003329_amyloid_beta_deposits0.69691529
155MP0000579_abnormal_nail_morphology0.68039540
156MP0005501_abnormal_skin_physiology0.67039746
157MP0002572_abnormal_emotion/affect_behav0.66726024
158MP0003938_abnormal_ear_development0.64890377
159MP0003984_embryonic_growth_retardation0.64509479
160MP0005164_abnormal_response_to0.64324324
161MP0002751_abnormal_autonomic_nervous0.64114056
162MP0006036_abnormal_mitochondrial_physio0.63597961
163MP0001943_abnormal_respiration0.63556950
164MP0003936_abnormal_reproductive_system0.63141363
165MP0002736_abnormal_nociception_after0.63031751
166MP0005248_abnormal_Harderian_gland0.62386596
167MP0008004_abnormal_stomach_pH0.62335086
168MP0002088_abnormal_embryonic_growth/wei0.62255364
169MP0003123_paternal_imprinting0.60432630
170MP0005166_decreased_susceptibility_to0.60227253
171MP0009697_abnormal_copulation0.59298069
172MP0003385_abnormal_body_wall0.59126483
173MP0002734_abnormal_mechanical_nocicepti0.58808010
174MP0002295_abnormal_pulmonary_circulatio0.57646940
175MP0000516_abnormal_urinary_system0.57273807
176MP0005367_renal/urinary_system_phenotyp0.57273807
177MP0003252_abnormal_bile_duct0.56916015
178MP0000013_abnormal_adipose_tissue0.56436572
179MP0009745_abnormal_behavioral_response0.56321681
180MP0005085_abnormal_gallbladder_physiolo0.55299879
181MP0003787_abnormal_imprinting0.54714800
182MP0004133_heterotaxia0.54228443
183MP0002272_abnormal_nervous_system0.51438470

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)8.36113757
2Irregular epiphyses (HP:0010582)7.76444228
3Vitreoretinal degeneration (HP:0000655)7.74001314
4Hypoplastic ischia (HP:0003175)6.96038326
5Abnormality of the ischium (HP:0003174)6.25135793
6Cupped ribs (HP:0000887)6.02087148
7Neonatal short-limb short stature (HP:0008921)5.87565384
8Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.81773987
9Septo-optic dysplasia (HP:0100842)5.74822426
10Abnormal tarsal ossification (HP:0008369)5.04850742
11Flat capital femoral epiphysis (HP:0003370)5.02176993
12Small epiphyses (HP:0010585)4.95163845
13Flat acetabular roof (HP:0003180)4.78097995
14Rhinitis (HP:0012384)4.41380464
15Delayed epiphyseal ossification (HP:0002663)4.39221553
16Abnormality of the labia minora (HP:0012880)4.35022254
17Supernumerary spleens (HP:0009799)4.32158905
18Genu varum (HP:0002970)4.07531464
19Arthropathy (HP:0003040)4.00414672
20Flattened epiphyses (HP:0003071)4.00073043
21Absent septum pellucidum (HP:0001331)3.90336915
22Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.83690480
23Absent epiphyses (HP:0010577)3.83690480
24Abnormal ciliary motility (HP:0012262)3.76309129
25Colon cancer (HP:0003003)3.74111745
26Abnormal respiratory motile cilium physiology (HP:0012261)3.66605614
27Cervical subluxation (HP:0003308)3.57387860
28Abnormality of the septum pellucidum (HP:0007375)3.54868557
29Abnormality of the phalanges of the 2nd finger (HP:0009541)3.51046980
30Chromsome breakage (HP:0040012)3.49400453
31Abnormal foot bone ossification (HP:0010675)3.48412841
32Abnormal vertebral ossification (HP:0100569)3.47453123
33Oral leukoplakia (HP:0002745)3.45557151
34Osteoarthritis (HP:0002758)3.41871793
35Multiple enchondromatosis (HP:0005701)3.40820469
36Maternal diabetes (HP:0009800)3.39950400
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.39267082
38Increased hepatocellular lipid droplets (HP:0006565)3.38332847
39Abnormal lung lobation (HP:0002101)3.36616327
40Abnormality of the pubic bones (HP:0003172)3.36383234
41Thin ribs (HP:0000883)3.27663698
42Chromosomal breakage induced by crosslinking agents (HP:0003221)3.24698881
43Abnormality of the vertebral endplates (HP:0005106)3.19527937
44Glossoptosis (HP:0000162)3.19346666
45Thoracolumbar scoliosis (HP:0002944)3.16140946
46Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.14406838
47Abnormality of femoral epiphyses (HP:0006499)3.14406838
48Azoospermia (HP:0000027)3.12443555
49Protuberant abdomen (HP:0001538)3.11127207
50Aplastic anemia (HP:0001915)3.10445313
51Short femoral neck (HP:0100864)3.09860998
52Metaphyseal irregularity (HP:0003025)3.05654126
53Meckel diverticulum (HP:0002245)3.05059817
54Methylmalonic acidemia (HP:0002912)3.02458299
55Birth length less than 3rd percentile (HP:0003561)2.98011513
56Metaphyseal cupping (HP:0003021)2.97348235
57Irregular vertebral endplates (HP:0003301)2.96607508
58Megaloblastic anemia (HP:0001889)2.95162339
59Renal Fanconi syndrome (HP:0001994)2.91805784
60Impulsivity (HP:0100710)2.90681667
61Fibular hypoplasia (HP:0003038)2.89514286
62Vertebral clefting (HP:0008428)2.87450306
63Acute necrotizing encephalopathy (HP:0006965)2.84290384
64Lipid accumulation in hepatocytes (HP:0006561)2.84232025
65Abnormality of the proximal phalanges of the hand (HP:0009834)2.82550804
66Abnormality of the ileum (HP:0001549)2.81448094
67Vertebral hypoplasia (HP:0008417)2.80683828
68Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.80683828
69Aplasia/Hypoplasia of the scapulae (HP:0006713)2.80543507
70Hypoplastic scapulae (HP:0000882)2.80543507
71Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.80254460
72Abnormality of homocysteine metabolism (HP:0010919)2.78113198
73Homocystinuria (HP:0002156)2.78113198
74Barrel-shaped chest (HP:0001552)2.76401008
75Mild short stature (HP:0003502)2.73726460
76Hypoplastic pelvis (HP:0008839)2.72900967
77Abnormality of chromosome stability (HP:0003220)2.71872234
78Optic nerve hypoplasia (HP:0000609)2.70069377
79Abnormality of the epiphysis of the femoral head (HP:0010574)2.68315675
80Macrocytic anemia (HP:0001972)2.67086591
81Abnormal respiratory motile cilium morphology (HP:0005938)2.63561904
82Abnormal respiratory epithelium morphology (HP:0012253)2.63561904
83Cleft eyelid (HP:0000625)2.60929671
84Abnormality of the lumbar spine (HP:0100712)2.59913833
85Myokymia (HP:0002411)2.59807238
86Mixed hearing impairment (HP:0000410)2.58384417
87Aplasia/Hypoplasia of the uvula (HP:0010293)2.58350553
88Abnormality of the femoral head (HP:0003368)2.57596428
89Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.56990497
90Acute encephalopathy (HP:0006846)2.56370817
91Abnormality of the preputium (HP:0100587)2.54244666
92Abnormal spermatogenesis (HP:0008669)2.53788434
93Hypoplasia of the odontoid process (HP:0003311)2.53474256
94Osteomalacia (HP:0002749)2.52226101
95Hypoplastic ilia (HP:0000946)2.50885376
96Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.49404471
97Abnormality of abdominal situs (HP:0011620)2.47576818
98Abdominal situs inversus (HP:0003363)2.47576818
99Median cleft lip (HP:0000161)2.47576000
100Hip contracture (HP:0003273)2.46097189
101Limited hip movement (HP:0008800)2.45327239
102Reticulocytopenia (HP:0001896)2.44932873
103Beaking of vertebral bodies (HP:0004568)2.44460680
104Aplasia/Hypoplasia of the fovea (HP:0008060)2.43008033
105Hypoplasia of the fovea (HP:0007750)2.43008033
106Pendular nystagmus (HP:0012043)2.42473679
107Absent frontal sinuses (HP:0002688)2.42229555
108Nephroblastoma (Wilms tumor) (HP:0002667)2.40920817
109Abnormality of carpal bone ossification (HP:0006257)2.40755871
110Abnormality of the lacrimal duct (HP:0011481)2.40279665
111Tracheomalacia (HP:0002779)2.39216702
112Small intestinal stenosis (HP:0012848)2.38970802
113Duodenal stenosis (HP:0100867)2.38970802
114Exertional dyspnea (HP:0002875)2.38469310
115Sparse eyelashes (HP:0000653)2.37499386
116Ovoid vertebral bodies (HP:0003300)2.37398954
117Coxa vara (HP:0002812)2.35986073
118Congenital, generalized hypertrichosis (HP:0004540)2.34732671
119Facial hemangioma (HP:0000329)2.34486996
120Gonadotropin excess (HP:0000837)2.34217413
121Progressive macrocephaly (HP:0004481)2.32249328
122Abnormality of incisor morphology (HP:0011063)2.31414634
123Abnormality of methionine metabolism (HP:0010901)2.28815642
124Abnormality of the phalanges of the 5th finger (HP:0004213)2.28677394
125Abnormality of the 2nd finger (HP:0004100)2.28599480
126Abnormality of aspartate family amino acid metabolism (HP:0010899)2.28377147
127Radial bowing (HP:0002986)2.28371048
128Aplasia/hypoplasia of the femur (HP:0005613)2.28318456
129Hypophosphatemic rickets (HP:0004912)2.28170098
130Facial cleft (HP:0002006)2.27517480
131Abnormal number of erythroid precursors (HP:0012131)2.27077332
132Hypoplastic iliac wings (HP:0002866)2.26747979
133Selective tooth agenesis (HP:0001592)2.26538901
134Abnormal mitochondria in muscle tissue (HP:0008316)2.26072794
135Tracheoesophageal fistula (HP:0002575)2.25181101
136Aplasia/Hypoplasia of the fibula (HP:0006492)2.24177834
137Platyspondyly (HP:0000926)2.23126208
138Exostoses (HP:0100777)2.23101061
139Embryonal renal neoplasm (HP:0011794)2.22807240
140Hypoglycemic seizures (HP:0002173)2.22029714
141Disproportionate short-trunk short stature (HP:0003521)2.21396351
142Mitochondrial inheritance (HP:0001427)2.21172568
143Bilateral microphthalmos (HP:0007633)2.20779764
144Long clavicles (HP:0000890)2.19904329
145Hyperglycinemia (HP:0002154)2.18765401
146Oligodactyly (hands) (HP:0001180)2.18153672
147Aplasia/Hypoplasia involving the vertebral column (HP:0008518)2.17811801
148Hypoglycemic coma (HP:0001325)2.17739786
149Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.17028307
150Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.16770584
151Stillbirth (HP:0003826)2.16214916
152Abnormal cartilage morphology (HP:0002763)2.15333182
153Methylmalonic aciduria (HP:0012120)2.15149899
154Abnormality of the fovea (HP:0000493)2.13692594
155Pancreatic islet-cell hyperplasia (HP:0004510)2.13532117
156Abnormality of the nasolacrimal system (HP:0000614)2.13503516
157Nasolacrimal duct obstruction (HP:0000579)2.13220427
158Anterior segment dysgenesis (HP:0007700)2.12775104
159Spinal cord compression (HP:0002176)2.12737334
160Ulnar bowing (HP:0003031)2.12353123
161Abnormality of cells of the erythroid lineage (HP:0012130)2.11988197
162Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.10225969
163Mesomelia (HP:0003027)2.09774470
164Abnormality of the duodenum (HP:0002246)2.09513223
165Bifid tongue (HP:0010297)2.09202128
166Limited elbow extension (HP:0001377)2.08221942
167Abnormality of the vitreous humor (HP:0004327)2.08063287
168True hermaphroditism (HP:0010459)2.07058213
169Short tibia (HP:0005736)2.04867013
170Absent radius (HP:0003974)2.04859961
171Bronchomalacia (HP:0002780)2.03156428
172Abnormality of the odontoid process (HP:0003310)2.02929565
173Flared metaphyses (HP:0003015)2.02242837
174Absent thumb (HP:0009777)2.01081796
175Abnormality of the fibula (HP:0002991)2.00293816
176Abnormality of renal resorption (HP:0011038)1.99996419
177Abnormality of sulfur amino acid metabolism (HP:0004339)1.99844084
178Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.98643167
179Increased CSF lactate (HP:0002490)1.98367286
180Premature ovarian failure (HP:0008209)1.94902182
181Hyperinsulinemic hypoglycemia (HP:0000825)1.94726000
182Chronic bronchitis (HP:0004469)1.93106902
183Cellular immunodeficiency (HP:0005374)1.92512501
184Bell-shaped thorax (HP:0001591)1.92365118
185Short ribs (HP:0000773)1.92047920
186Bronchiectasis (HP:0002110)1.92001953
187Micromelia (HP:0002983)1.91927700
188Waddling gait (HP:0002515)1.90939071
189Rhabdomyosarcoma (HP:0002859)1.90743484
190Absent forearm bone (HP:0003953)1.90256897
191Aplasia involving forearm bones (HP:0009822)1.90256897
192Abnormality of the wing of the ilium (HP:0011867)1.89619290
193Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.88706348
194Triphalangeal thumb (HP:0001199)1.87757320
195Pallor (HP:0000980)1.86510020
196Infertility (HP:0000789)1.85119971
197Abnormal trabecular bone morphology (HP:0100671)1.82535164
198Neoplasm of the colon (HP:0100273)1.81279968
199Non-midline cleft lip (HP:0100335)1.81098515
200Abnormality of the vitamin B12 metabolism (HP:0004341)1.80499177

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR27.88078651
2MAPK156.35685297
3CDC74.67952084
4BUB14.28174322
5VRK23.92984254
6TNIK3.91135281
7PNCK3.77443243
8BRSK23.37962647
9TTK3.28724765
10WEE12.91139634
11MAP3K92.85593348
12PRKD32.65219164
13PRKG22.60756144
14ZAK2.33119541
15STK242.21592424
16TAF12.09817544
17ARAF2.08042394
18PLK22.06798838
19SRPK12.06698302
20PLK11.91564594
21MAP3K131.90842966
22PTK2B1.82001106
23STK161.80596627
24EPHA41.78600221
25EIF2AK31.73041391
26PKN21.72768194
27DYRK21.58702411
28AURKA1.53543246
29PBK1.49988440
30PLK41.47471638
31NEK61.46977493
32MST41.44117290
33BRAF1.39371862
34NME11.36711837
35CHEK21.35102227
36MAP3K31.29454852
37BRSK11.27514065
38MKNK21.23846479
39CDK91.23433421
40GRK11.22849898
41ERBB31.22839797
42MAP3K41.21377816
43FGFR11.21235269
44MAP3K101.20879258
45EPHB21.13757876
46CDK71.12796136
47NEK21.11565964
48TIE11.10886790
49STK31.10627698
50SIK11.09540872
51CDK191.09051563
52BMPR1B1.08915688
53PAK21.05620944
54PRKCH1.05397138
55AURKB1.04981705
56NTRK21.04414493
57MAPK71.02423133
58BCR1.01813835
59MUSK1.00427563
60CSNK1G10.99804761
61VRK10.99361693
62FGFR30.97614570
63MAPK120.96716466
64DYRK30.95613684
65ACVR1B0.95228341
66PRKCG0.94063084
67CDC42BPA0.93976917
68NTRK30.92938249
69ROCK10.91778014
70EIF2AK10.87455870
71ROCK20.85908495
72WNK30.85664417
73ATR0.85585501
74STK40.84957989
75CHEK10.84760089
76NME20.84536290
77OXSR10.84106236
78NLK0.82398965
79MAP2K20.81242949
80PRKCE0.80400064
81DYRK1A0.77246642
82LMTK20.76895374
83PRKCI0.76835005
84MINK10.75511874
85ATM0.75273146
86MAP3K140.75215014
87TRPM70.75100808
88BMPR20.74444023
89LATS20.74091123
90MET0.73551683
91PLK30.72681668
92GSK3A0.71727129
93NTRK10.67097662
94CDK20.66734105
95PTK60.66384980
96PRKD20.65680065
97NUAK10.65145025
98PIM10.63018042
99MELK0.61179461
100CDK10.60954711
101STK390.59955378
102DMPK0.59086458
103NEK10.58959377
104PTK20.57986721
105MOS0.56259241
106MAP3K80.55889712
107CAMK1G0.55154302
108MKNK10.54803232
109PAK10.52973470
110TRIM280.52286689
111IRAK30.52087254
112GRK60.51160915
113CSNK2A20.49936013
114LATS10.49251723
115INSR0.48826676
116CSNK2A10.48076409
117FLT30.47874116
118CSNK1G20.47865192
119CAMK2A0.47796502
120MAPK40.47291849
121EIF2AK20.46414726
122PRKACG0.46087372
123CDK50.42690258
124CSNK1E0.42536384
125INSRR0.42239153
126CDK120.42108952
127CAMK2D0.41889218
128SRC0.41877730
129PDK20.40212717
130CSNK1G30.39877372
131RAF10.39651713
132ITK0.39160681
133PRKAA20.39016509
134PIM20.38637136
135PRKCD0.38613889
136MAP2K40.38583546
137PRKACA0.38197307
138ABL10.37861775
139GRK50.36344948
140CSNK1D0.36192264
141CDK30.35913401
142IGF1R0.34903162
143MARK30.33634233
144TEC0.33387932
145TSSK60.33259806
146MAPKAPK20.33232234
147ALK0.32728336
148CAMK2B0.32668525
149WNK40.32552390
150MAP2K70.31142685
151MARK10.30198139
152PRKCA0.30127611
153PDK10.29654178
154CAMKK20.29300321
155STK38L0.28899492
156EGFR0.28238212
157WNK10.28043663
158PAK60.27978344
159MAPK30.27935474
160PRKDC0.26761127
161ADRBK10.26653223
162MAPK130.26565243
163MAPKAPK30.26474968
164PRKACB0.26050681
165YES10.25634979
166CAMK1D0.25602031
167MAPK100.25314934
168PRKG10.25054078
169GSK3B0.24295421
170TLK10.21367837
171PAK40.20605658
172TAOK30.20193964
173DAPK10.17822870
174CAMK10.15976960

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.51833617
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.30238117
3Mismatch repair_Homo sapiens_hsa034304.28590499
4RNA polymerase_Homo sapiens_hsa030203.62404354
5DNA replication_Homo sapiens_hsa030303.62332686
6Protein digestion and absorption_Homo sapiens_hsa049743.57614865
7Ribosome_Homo sapiens_hsa030103.46438386
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.22506829
9Proteasome_Homo sapiens_hsa030503.12088499
10Basal transcription factors_Homo sapiens_hsa030223.07845420
11Olfactory transduction_Homo sapiens_hsa047402.71183041
12Homologous recombination_Homo sapiens_hsa034402.70965250
13Cell cycle_Homo sapiens_hsa041102.65289776
14Parkinsons disease_Homo sapiens_hsa050122.59791340
15RNA degradation_Homo sapiens_hsa030182.52673833
16Spliceosome_Homo sapiens_hsa030402.43595261
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40649137
18Base excision repair_Homo sapiens_hsa034102.40384728
19RNA transport_Homo sapiens_hsa030132.31930137
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.17647470
21Nucleotide excision repair_Homo sapiens_hsa034202.04997702
22Non-homologous end-joining_Homo sapiens_hsa034502.01481706
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.90036187
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.81420230
25Fanconi anemia pathway_Homo sapiens_hsa034601.81039691
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.78279553
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.77081729
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73095009
29Folate biosynthesis_Homo sapiens_hsa007901.70880832
30Salivary secretion_Homo sapiens_hsa049701.69750151
31Focal adhesion_Homo sapiens_hsa045101.65407049
32Oocyte meiosis_Homo sapiens_hsa041141.65076548
33Sulfur metabolism_Homo sapiens_hsa009201.60398267
34Amphetamine addiction_Homo sapiens_hsa050311.59566215
35Nicotine addiction_Homo sapiens_hsa050331.56102375
36Circadian entrainment_Homo sapiens_hsa047131.54949659
37Vitamin digestion and absorption_Homo sapiens_hsa049771.52579200
38Sphingolipid metabolism_Homo sapiens_hsa006001.52248317
39GABAergic synapse_Homo sapiens_hsa047271.51074481
40Pyrimidine metabolism_Homo sapiens_hsa002401.48972314
41Starch and sucrose metabolism_Homo sapiens_hsa005001.48732426
42One carbon pool by folate_Homo sapiens_hsa006701.46262879
43Nitrogen metabolism_Homo sapiens_hsa009101.45292363
44Gastric acid secretion_Homo sapiens_hsa049711.39895377
45Glutamatergic synapse_Homo sapiens_hsa047241.37640370
46Purine metabolism_Homo sapiens_hsa002301.30725018
47mRNA surveillance pathway_Homo sapiens_hsa030151.29454331
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29207571
49Mineral absorption_Homo sapiens_hsa049781.26639239
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.26623883
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.25699093
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25293257
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25269682
54Pyruvate metabolism_Homo sapiens_hsa006201.24048715
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23869295
56Dilated cardiomyopathy_Homo sapiens_hsa054141.21261326
57Caffeine metabolism_Homo sapiens_hsa002321.20123402
58Thyroid hormone synthesis_Homo sapiens_hsa049181.18527947
59Renin secretion_Homo sapiens_hsa049241.14218995
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13133587
61Long-term potentiation_Homo sapiens_hsa047201.13125747
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12067052
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10758765
64Vitamin B6 metabolism_Homo sapiens_hsa007501.09957553
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07523841
66Insulin secretion_Homo sapiens_hsa049111.05215782
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03707935
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03217039
69Bile secretion_Homo sapiens_hsa049761.02890658
70Aldosterone synthesis and secretion_Homo sapiens_hsa049251.02680301
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02467069
72Melanogenesis_Homo sapiens_hsa049161.02371080
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02063630
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02056213
75TGF-beta signaling pathway_Homo sapiens_hsa043501.01245385
76Basal cell carcinoma_Homo sapiens_hsa052170.99621037
77Butanoate metabolism_Homo sapiens_hsa006500.99228904
78Thyroid cancer_Homo sapiens_hsa052160.95194653
79Long-term depression_Homo sapiens_hsa047300.92766112
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92748148
81Malaria_Homo sapiens_hsa051440.91948184
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90417084
83Other glycan degradation_Homo sapiens_hsa005110.90216511
84Cocaine addiction_Homo sapiens_hsa050300.88189646
85Proteoglycans in cancer_Homo sapiens_hsa052050.87058303
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.86834499
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86161963
88Vibrio cholerae infection_Homo sapiens_hsa051100.85921622
89Fatty acid elongation_Homo sapiens_hsa000620.85276437
90p53 signaling pathway_Homo sapiens_hsa041150.84461631
91Gap junction_Homo sapiens_hsa045400.82882300
92Selenocompound metabolism_Homo sapiens_hsa004500.80829425
93Arginine biosynthesis_Homo sapiens_hsa002200.80787317
94Hippo signaling pathway_Homo sapiens_hsa043900.79812003
95cAMP signaling pathway_Homo sapiens_hsa040240.77638230
96Arginine and proline metabolism_Homo sapiens_hsa003300.76746339
97Wnt signaling pathway_Homo sapiens_hsa043100.75964375
98Oxytocin signaling pathway_Homo sapiens_hsa049210.75359388
99Hedgehog signaling pathway_Homo sapiens_hsa043400.75029064
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74761691
101Dopaminergic synapse_Homo sapiens_hsa047280.74742210
102Morphine addiction_Homo sapiens_hsa050320.73148113
103Huntingtons disease_Homo sapiens_hsa050160.72940853
104Protein export_Homo sapiens_hsa030600.71330696
105Propanoate metabolism_Homo sapiens_hsa006400.70380711
106Estrogen signaling pathway_Homo sapiens_hsa049150.69496103
107GnRH signaling pathway_Homo sapiens_hsa049120.67969941
108Ether lipid metabolism_Homo sapiens_hsa005650.65957472
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65246360
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64644853
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63906334
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62880255
113Phototransduction_Homo sapiens_hsa047440.62660318
114Rheumatoid arthritis_Homo sapiens_hsa053230.62284631
115Steroid biosynthesis_Homo sapiens_hsa001000.61549114
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61141577
117Calcium signaling pathway_Homo sapiens_hsa040200.60584270
118Glutathione metabolism_Homo sapiens_hsa004800.60001141
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59104532
120Ovarian steroidogenesis_Homo sapiens_hsa049130.59096817
121Cardiac muscle contraction_Homo sapiens_hsa042600.58603135
122Complement and coagulation cascades_Homo sapiens_hsa046100.57418261
123Cholinergic synapse_Homo sapiens_hsa047250.57322423
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56884907
125Axon guidance_Homo sapiens_hsa043600.56321718
126Metabolic pathways_Homo sapiens_hsa011000.54609111
127Collecting duct acid secretion_Homo sapiens_hsa049660.54228506
128Glucagon signaling pathway_Homo sapiens_hsa049220.52010017
129PPAR signaling pathway_Homo sapiens_hsa033200.48782434
130Serotonergic synapse_Homo sapiens_hsa047260.46869884
131HIF-1 signaling pathway_Homo sapiens_hsa040660.46477289
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46222428
133Taste transduction_Homo sapiens_hsa047420.44997540
134Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41913338
135Renin-angiotensin system_Homo sapiens_hsa046140.41068007
136Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41058762
137Circadian rhythm_Homo sapiens_hsa047100.40933354
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40896272
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40734877
140Oxidative phosphorylation_Homo sapiens_hsa001900.40280747
141Pancreatic secretion_Homo sapiens_hsa049720.38927118
142Adherens junction_Homo sapiens_hsa045200.38487744
143Arachidonic acid metabolism_Homo sapiens_hsa005900.38076865
144Vascular smooth muscle contraction_Homo sapiens_hsa042700.37933434
145Primary bile acid biosynthesis_Homo sapiens_hsa001200.37806472
146Retinol metabolism_Homo sapiens_hsa008300.36060503
147Alzheimers disease_Homo sapiens_hsa050100.35820199
148Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35634813
149Phagosome_Homo sapiens_hsa041450.35269470
150Chemical carcinogenesis_Homo sapiens_hsa052040.35208472
151Epstein-Barr virus infection_Homo sapiens_hsa051690.33399122
152Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33373954
153Biosynthesis of amino acids_Homo sapiens_hsa012300.28231146
154beta-Alanine metabolism_Homo sapiens_hsa004100.27305507
155Tight junction_Homo sapiens_hsa045300.26006661
156Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23624186
157Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22859083
158Linoleic acid metabolism_Homo sapiens_hsa005910.13452218
159Drug metabolism - other enzymes_Homo sapiens_hsa009830.12833925
160Fat digestion and absorption_Homo sapiens_hsa049750.09893203
161Melanoma_Homo sapiens_hsa052180.09807767
162Carbon metabolism_Homo sapiens_hsa012000.08645648
163Tryptophan metabolism_Homo sapiens_hsa003800.08178724
164Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.03354430
165HTLV-I infection_Homo sapiens_hsa051660.03255245
166Systemic lupus erythematosus_Homo sapiens_hsa053220.02676599
1672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.02376617
168MicroRNAs in cancer_Homo sapiens_hsa052060.01757525
169Pathways in cancer_Homo sapiens_hsa052000.01158802

Most similar genes based on co-expression Upload to Enrichr

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