UCK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1valine metabolic process (GO:0006573)6.59258421
2alpha-linolenic acid metabolic process (GO:0036109)5.48924314
3regulation of sequestering of triglyceride (GO:0010889)5.27929014
4fatty acid beta-oxidation (GO:0006635)5.25400051
5L-phenylalanine metabolic process (GO:0006558)5.25149784
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.25149784
7lysine catabolic process (GO:0006554)5.17907418
8lysine metabolic process (GO:0006553)5.17907418
9L-phenylalanine catabolic process (GO:0006559)5.14624943
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.14624943
11triglyceride catabolic process (GO:0019433)5.11598678
12biotin metabolic process (GO:0006768)4.94180420
13branched-chain amino acid catabolic process (GO:0009083)4.88720830
14acylglycerol catabolic process (GO:0046464)4.88587990
15neutral lipid catabolic process (GO:0046461)4.88587990
16branched-chain amino acid metabolic process (GO:0009081)4.84761910
17low-density lipoprotein particle clearance (GO:0034383)4.83973432
18fatty acid oxidation (GO:0019395)4.82877662
19tricarboxylic acid metabolic process (GO:0072350)4.73800736
20lipid oxidation (GO:0034440)4.70996290
21fatty acid catabolic process (GO:0009062)4.70811363
22sulfur amino acid catabolic process (GO:0000098)4.67253289
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.66368712
24DNA unwinding involved in DNA replication (GO:0006268)4.60229185
25acetyl-CoA metabolic process (GO:0006084)4.57485332
26DNA strand elongation involved in DNA replication (GO:0006271)4.55565701
27NADH metabolic process (GO:0006734)4.43064088
28DNA strand elongation (GO:0022616)4.42756624
29L-serine metabolic process (GO:0006563)4.41187958
30protein maturation by protein folding (GO:0022417)4.40312643
31cysteine metabolic process (GO:0006534)4.39165213
32regulation of triglyceride catabolic process (GO:0010896)4.37027591
33positive regulation of fatty acid beta-oxidation (GO:0032000)4.33952280
34triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.29076041
35peptidyl-arginine omega-N-methylation (GO:0035247)4.27670307
36pentose-phosphate shunt (GO:0006098)4.27019447
37glyoxylate metabolic process (GO:0046487)4.26397884
38fatty acid transmembrane transport (GO:1902001)4.24840225
392-oxoglutarate metabolic process (GO:0006103)4.23663865
40amino-acid betaine metabolic process (GO:0006577)4.23572161
41positive regulation of fatty acid oxidation (GO:0046321)4.19345912
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.17942314
43regulation of fatty acid oxidation (GO:0046320)4.13933987
44short-chain fatty acid metabolic process (GO:0046459)4.13744257
45proline biosynthetic process (GO:0006561)4.13279273
46monocarboxylic acid catabolic process (GO:0072329)4.12375024
47aromatic amino acid family catabolic process (GO:0009074)4.10352091
48regulation of mammary gland epithelial cell proliferation (GO:0033599)4.06651928
49telomere maintenance via semi-conservative replication (GO:0032201)4.06164718
50regulation of fatty acid beta-oxidation (GO:0031998)4.05334847
51carnitine shuttle (GO:0006853)4.05224119
52NADPH regeneration (GO:0006740)4.04840307
53carnitine metabolic process (GO:0009437)4.04538026
54thioester biosynthetic process (GO:0035384)3.98780635
55acyl-CoA biosynthetic process (GO:0071616)3.98780635
56tricarboxylic acid cycle (GO:0006099)3.90701618
57pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.89739494
58oxaloacetate metabolic process (GO:0006107)3.89647452
59ethanol oxidation (GO:0006069)3.89539168
60white fat cell differentiation (GO:0050872)3.75119817
61plasma lipoprotein particle clearance (GO:0034381)3.74712786
62fatty-acyl-CoA biosynthetic process (GO:0046949)3.72853024
63ribosomal small subunit biogenesis (GO:0042274)3.72560950
64complement activation, alternative pathway (GO:0006957)3.70253366
65positive regulation of lipid catabolic process (GO:0050996)3.69486225
66succinate metabolic process (GO:0006105)3.69377847
67histone arginine methylation (GO:0034969)3.68683276
68bile acid biosynthetic process (GO:0006699)3.68265178
69regulation of cholesterol storage (GO:0010885)3.65902370
70* nucleotide salvage (GO:0043173)3.64493714
71DNA replication initiation (GO:0006270)3.60293489
72triglyceride homeostasis (GO:0070328)3.57084476
73acylglycerol homeostasis (GO:0055090)3.57084476
74negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.57076693
75organic acid catabolic process (GO:0016054)3.55671940
76carboxylic acid catabolic process (GO:0046395)3.55671940
77positive regulation of triglyceride metabolic process (GO:0090208)3.54627989
78coenzyme A metabolic process (GO:0015936)3.53277634
79brown fat cell differentiation (GO:0050873)3.51629634
80thioester metabolic process (GO:0035383)3.50705531
81acyl-CoA metabolic process (GO:0006637)3.50705531
82serine family amino acid catabolic process (GO:0009071)3.47039881
83fatty-acyl-CoA metabolic process (GO:0035337)3.45969962
84coenzyme A biosynthetic process (GO:0015937)3.45541010
85positive regulation of fatty acid metabolic process (GO:0045923)3.43445250
86triglyceride metabolic process (GO:0006641)3.42430098
87alpha-amino acid catabolic process (GO:1901606)3.41449451
88triglyceride biosynthetic process (GO:0019432)3.41441047
89protein retention in ER lumen (GO:0006621)3.41180630
90aspartate family amino acid catabolic process (GO:0009068)3.41013907
91glycine metabolic process (GO:0006544)3.40731056
92cellular amino acid catabolic process (GO:0009063)3.39576291
93pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.39387735
94heterochromatin organization (GO:0070828)3.38916062
95cellular ketone body metabolic process (GO:0046950)3.37986028
96regulation of mitochondrial translation (GO:0070129)3.35476928
97nucleobase-containing small molecule interconversion (GO:0015949)3.35386802
98carnitine transport (GO:0015879)3.35228959
99amino-acid betaine transport (GO:0015838)3.35228959
100serine family amino acid metabolic process (GO:0009069)3.35048669
101glycerolipid catabolic process (GO:0046503)3.34826526
102pantothenate metabolic process (GO:0015939)3.33643802
103serine family amino acid biosynthetic process (GO:0009070)3.30165464
104carnitine transmembrane transport (GO:1902603)3.30067371
105peptidyl-arginine N-methylation (GO:0035246)3.29951599
106peptidyl-arginine methylation (GO:0018216)3.29951599
107long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.29725030
108kynurenine metabolic process (GO:0070189)3.29690050
109protein complex localization (GO:0031503)3.28726244
110acylglycerol biosynthetic process (GO:0046463)3.28280318
111neutral lipid biosynthetic process (GO:0046460)3.28280318
112NADP metabolic process (GO:0006739)3.28018788
113* pyrimidine nucleoside salvage (GO:0043097)3.25440482
114* pyrimidine-containing compound salvage (GO:0008655)3.25440482
115urea cycle (GO:0000050)3.24566399
116urea metabolic process (GO:0019627)3.24566399
117indole-containing compound catabolic process (GO:0042436)3.24356116
118indolalkylamine catabolic process (GO:0046218)3.24356116
119tryptophan catabolic process (GO:0006569)3.24356116
120regulation of cholesterol metabolic process (GO:0090181)3.23945203
121mitotic chromosome condensation (GO:0007076)3.23408360
122acylglycerol metabolic process (GO:0006639)3.23022246
123deoxyribonucleotide catabolic process (GO:0009264)3.20653372
124quaternary ammonium group transport (GO:0015697)3.20648401
125regulation of triglyceride metabolic process (GO:0090207)3.20040627
126proline metabolic process (GO:0006560)3.19128432
127gluconeogenesis (GO:0006094)3.17750551
128neutral lipid metabolic process (GO:0006638)3.17381077
129spliceosomal tri-snRNP complex assembly (GO:0000244)3.17330137
130establishment of integrated proviral latency (GO:0075713)3.17216255
131negative regulation of cell size (GO:0045792)3.15823605
132monosaccharide biosynthetic process (GO:0046364)3.14765971
133pyrimidine nucleotide catabolic process (GO:0006244)3.14598039
134tryptophan metabolic process (GO:0006568)3.14252053
135deoxyribose phosphate biosynthetic process (GO:0046385)3.14009784
1362-deoxyribonucleotide biosynthetic process (GO:0009265)3.14009784
137homocysteine metabolic process (GO:0050667)3.10992755
138melanin biosynthetic process (GO:0042438)3.08371605
139formation of translation preinitiation complex (GO:0001731)3.07439811
140UV protection (GO:0009650)3.06189809
141mitochondrial fusion (GO:0008053)3.04612526
142deoxyribose phosphate catabolic process (GO:0046386)3.03572594
143GDP-mannose metabolic process (GO:0019673)3.01749761
144negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.01314270
145glucose catabolic process (GO:0006007)3.00959977
146cellular protein complex localization (GO:0034629)3.00063462
147positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.99042082
148deoxyribonucleotide biosynthetic process (GO:0009263)2.97123165
149maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.96798264
150telomere maintenance via recombination (GO:0000722)2.95472592
151barbed-end actin filament capping (GO:0051016)2.95218428
152hexose biosynthetic process (GO:0019319)2.95189173
153establishment of viral latency (GO:0019043)2.84745698
154pentose metabolic process (GO:0019321)2.81745668
155regulation of translational fidelity (GO:0006450)2.80094330
156purine deoxyribonucleotide catabolic process (GO:0009155)2.79108799
157viral transcription (GO:0019083)2.78677165
158folic acid metabolic process (GO:0046655)2.77580167
159melanin metabolic process (GO:0006582)2.76037936
160creatine metabolic process (GO:0006600)2.75722873
161base-excision repair (GO:0006284)2.74413302
162nuclear envelope reassembly (GO:0031468)2.73225831
163mitotic nuclear envelope reassembly (GO:0007084)2.73225831
164rRNA transcription (GO:0009303)2.73154558
165ribosomal small subunit assembly (GO:0000028)2.71843014
166epithelial cell differentiation involved in prostate gland development (GO:0060742)2.70098785
167regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.67144072
168COPI coating of Golgi vesicle (GO:0048205)2.66745633
169Golgi transport vesicle coating (GO:0048200)2.66745633
170cellular hyperosmotic response (GO:0071474)2.66251846
171mitotic recombination (GO:0006312)2.66228763
172ribosome biogenesis (GO:0042254)2.63922191
173mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.63026616
174ribonucleoprotein complex biogenesis (GO:0022613)2.59145276
175retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.56603409
176modulation by virus of host process (GO:0019054)2.55964285
177* nucleoside salvage (GO:0043174)2.55334117
178regulation of early endosome to late endosome transport (GO:2000641)2.53989065
179translational elongation (GO:0006414)2.53803852
180purine nucleotide salvage (GO:0032261)2.53555235
181IMP biosynthetic process (GO:0006188)2.52749010
182dosage compensation (GO:0007549)2.52442087
183* pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.51952866
184translational termination (GO:0006415)2.51450368
185ncRNA 3-end processing (GO:0043628)2.50928782
186regulation of superoxide anion generation (GO:0032928)2.50836982
187negative regulation of DNA-templated transcription, elongation (GO:0032785)2.50283903
188chaperone-mediated protein transport (GO:0072321)2.49552416
189nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.49188690
190* pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.48234195
191telomere maintenance via telomere lengthening (GO:0010833)2.48038649
192protein insertion into membrane (GO:0051205)2.47920981
193base-excision repair, AP site formation (GO:0006285)2.47270595
194protein localization to endosome (GO:0036010)2.45238537

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.52855406
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.40367197
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.49404257
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.09920494
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.97932727
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.77821324
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.27823643
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.18446032
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.03079806
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.59892222
11CLOCK_20551151_ChIP-Seq_293T_Human2.57575575
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.50489274
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.39380593
14E2F7_22180533_ChIP-Seq_HELA_Human2.16916443
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00998162
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86351966
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84098906
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.78085233
19MYC_18555785_ChIP-Seq_MESCs_Mouse1.77649753
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.75698168
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.72256868
22GATA1_22025678_ChIP-Seq_K562_Human1.67973170
23MYC_22102868_ChIP-Seq_BL_Human1.64750809
24ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.56867020
25SRY_22984422_ChIP-ChIP_TESTIS_Rat1.56246788
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.55321620
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.54860387
28CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50390438
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50275452
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48072245
31ZNF263_19887448_ChIP-Seq_K562_Human1.47839739
32VDR_21846776_ChIP-Seq_THP-1_Human1.47658989
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45612990
34ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38880500
35KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37235082
36SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.36390116
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.35330121
38KDM2B_26808549_Chip-Seq_DND41_Human1.35107326
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34417616
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33105342
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33093235
42LXR_22292898_ChIP-Seq_THP-1_Human1.32941984
43TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32686369
44CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32213241
45SA1_27219007_Chip-Seq_ERYTHROID_Human1.31036670
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30703854
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28842566
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28761252
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27020547
50XRN2_22483619_ChIP-Seq_HELA_Human1.25470896
51* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.25402410
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24190908
53FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24092917
54HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.23969884
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23432906
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.23404795
57* SMC4_20622854_ChIP-Seq_HELA_Human1.22375970
58CIITA_25753668_ChIP-Seq_RAJI_Human1.22014573
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.21645119
60* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21221742
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18570702
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17758122
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17251048
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16804243
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16321510
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.16078655
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15973570
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15890335
69TCF7_22412390_ChIP-Seq_EML_Mouse1.15476743
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14720737
71* GABP_19822575_ChIP-Seq_HepG2_Human1.14579335
72PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14009545
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13858325
74SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.13250868
75* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11903507
76DCP1A_22483619_ChIP-Seq_HELA_Human1.10664161
77* CTCF_26484167_Chip-Seq_Bcells_Mouse1.09690635
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09276520
79* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07383761
80NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07153770
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06479737
82KDM2B_26808549_Chip-Seq_K562_Human1.06144674
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05765168
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05324046
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05259345
86TTF2_22483619_ChIP-Seq_HELA_Human1.04988528
87SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04581961
88SRF_21415370_ChIP-Seq_HL-1_Mouse1.03767109
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03484648
90GABP_17652178_ChIP-ChIP_JURKAT_Human1.03364977
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03241149
92MYC_19030024_ChIP-ChIP_MESCs_Mouse1.03237651
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01633502
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00918390
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99756093
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99205448
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99118331
98* TET1_21451524_ChIP-Seq_MESCs_Mouse0.98867968
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98501204
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97217971
101ELK3_25401928_ChIP-Seq_HUVEC_Human0.96840283
102IRF8_22096565_ChIP-ChIP_GC-B_Human0.96550128
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95983395
104E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94823781
105SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94099764
106EST1_17652178_ChIP-ChIP_JURKAT_Human0.94013434
107CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93746613
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93568818
109ELF1_20517297_ChIP-Seq_JURKAT_Human0.93252090
110AR_21909140_ChIP-Seq_LNCAP_Human0.92653310
111NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92641117
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92594663
113BCL6_27268052_Chip-Seq_Bcells_Human0.92481434
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92386218
115* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92328472
116SCL_19346495_ChIP-Seq_HPC-7_Human0.90135703
117* P68_20966046_ChIP-Seq_HELA_Human0.89080653
118ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88471516
119* BCOR_27268052_Chip-Seq_Bcells_Human0.88383156
120SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88086234
121FOXP3_21729870_ChIP-Seq_TREG_Human0.87727850
122KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87581412
123MYC_19079543_ChIP-ChIP_MESCs_Mouse0.87306192
124TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85357844
125PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84880317
126FOXP1_21924763_ChIP-Seq_HESCs_Human0.84714407
127VDR_23849224_ChIP-Seq_CD4+_Human0.84416891
128MAF_26560356_Chip-Seq_TH1_Human0.84242395
129CTCF_21964334_Chip-Seq_Bcells_Human0.84014124
130ATF3_27146783_Chip-Seq_COLON_Human0.83848687
131* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.83712977
132MAF_26560356_Chip-Seq_TH2_Human0.82819021
133KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81605355
134RACK7_27058665_Chip-Seq_MCF-7_Human0.81340938
135CTCF_21964334_ChIP-Seq_BJAB-B_Human0.80872420
136VDR_24763502_ChIP-Seq_THP-1_Human0.80267591
137* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78879791
138* UTX_26944678_Chip-Seq_JUKART_Human0.78679143
139FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.78608787
140POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78265222

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.58646629
2MP0005360_urolithiasis5.22409263
3MP0005670_abnormal_white_adipose4.61407467
4MP0005365_abnormal_bile_salt4.61098217
5MP0008260_abnormal_autophagy3.96718968
6MP0005085_abnormal_gallbladder_physiolo3.58082645
7MP0010329_abnormal_lipoprotein_level3.48605859
8MP0003111_abnormal_nucleus_morphology3.33324859
9MP0005666_abnormal_adipose_tissue3.28233579
10MP0004130_abnormal_muscle_cell3.25262550
11MP0003693_abnormal_embryo_hatching3.04507052
12MP0003806_abnormal_nucleotide_metabolis3.04468217
13MP0008875_abnormal_xenobiotic_pharmacok2.85966075
14MP0010094_abnormal_chromosome_stability2.84880420
15MP0005332_abnormal_amino_acid2.82188058
16MP0003195_calcinosis2.78458191
17MP0002877_abnormal_melanocyte_morpholog2.68770747
18MP0004233_abnormal_muscle_weight2.57645561
19MP0004858_abnormal_nervous_system2.57101222
20MP0009278_abnormal_bone_marrow2.56405561
21MP0004185_abnormal_adipocyte_glucose2.49135599
22MP0002118_abnormal_lipid_homeostasis2.43547894
23MP0003252_abnormal_bile_duct2.41906502
24MP0003191_abnormal_cellular_cholesterol2.39874772
25MP0001849_ear_inflammation2.32727032
26MP0000609_abnormal_liver_physiology2.30891274
27MP0005375_adipose_tissue_phenotype2.27195970
28MP0002971_abnormal_brown_adipose2.26919195
29MP0009840_abnormal_foam_cell2.25018695
30MP0010030_abnormal_orbit_morphology2.16518069
31MP0006036_abnormal_mitochondrial_physio2.13794563
32MP0005584_abnormal_enzyme/coenzyme_acti2.10202025
33MP0004957_abnormal_blastocyst_morpholog2.07271546
34MP0002822_catalepsy2.07095101
35MP0001666_abnormal_nutrient_absorption2.06466346
36MP0008932_abnormal_embryonic_tissue2.05130187
37MP0003077_abnormal_cell_cycle2.03147047
38MP0002249_abnormal_larynx_morphology1.95311669
39MP0009643_abnormal_urine_homeostasis1.91038994
40MP0003186_abnormal_redox_activity1.84254400
41MP0005319_abnormal_enzyme/_coenzyme1.81858351
42MP0005257_abnormal_intraocular_pressure1.76291854
43MP0001730_embryonic_growth_arrest1.73974219
44MP0008007_abnormal_cellular_replicative1.71877117
45MP0002970_abnormal_white_adipose1.71198666
46MP0000013_abnormal_adipose_tissue1.70429482
47MP0009379_abnormal_foot_pigmentation1.69503508
48MP0005334_abnormal_fat_pad1.69064095
49MP0000678_abnormal_parathyroid_gland1.68873573
50MP0000751_myopathy1.68317500
51MP0000003_abnormal_adipose_tissue1.65159548
52MP0000350_abnormal_cell_proliferation1.63889425
53MP0005535_abnormal_body_temperature1.63764132
54MP0003656_abnormal_erythrocyte_physiolo1.63483076
55MP0008058_abnormal_DNA_repair1.63087214
56MP0003123_paternal_imprinting1.60873668
57MP0005623_abnormal_meninges_morphology1.58463209
58MP0009115_abnormal_fat_cell1.57821284
59MP0002078_abnormal_glucose_homeostasis1.55557275
60MP0001764_abnormal_homeostasis1.55427632
61MP0005083_abnormal_biliary_tract1.55104991
62MP0003878_abnormal_ear_physiology1.52420858
63MP0005377_hearing/vestibular/ear_phenot1.52420858
64MP0008961_abnormal_basal_metabolism1.48881381
65MP0004019_abnormal_vitamin_homeostasis1.44924113
66MP0001346_abnormal_lacrimal_gland1.43053652
67MP0002653_abnormal_ependyma_morphology1.42116042
68MP0008438_abnormal_cutaneous_collagen1.39514442
69MP0001756_abnormal_urination1.38395515
70MP0000490_abnormal_crypts_of1.36085748
71MP0001661_extended_life_span1.34684155
72MP0005636_abnormal_mineral_homeostasis1.30657694
73MP0000681_abnormal_thyroid_gland1.28875972
74MP0000598_abnormal_liver_morphology1.28427579
75MP0000313_abnormal_cell_death1.27512610
76MP0003075_altered_response_to1.27510703
77MP0003879_abnormal_hair_cell1.26811665
78MP0000750_abnormal_muscle_regeneration1.24786150
79MP0005501_abnormal_skin_physiology1.23639594
80MP0003959_abnormal_lean_body1.22902440
81MP0005448_abnormal_energy_balance1.22685524
82MP0003136_yellow_coat_color1.21041148
83MP0005076_abnormal_cell_differentiation1.20054507
84MP0003453_abnormal_keratinocyte_physiol1.18580039
85MP0004147_increased_porphyrin_level1.15308702
86MP0002080_prenatal_lethality1.13417649
87MP0000759_abnormal_skeletal_muscle1.13061150
88MP0003705_abnormal_hypodermis_morpholog1.11833826
89MP0004043_abnormal_pH_regulation1.06994874
90MP0005452_abnormal_adipose_tissue1.00998570
91MP0006035_abnormal_mitochondrial_morpho0.99883474
92MP0005058_abnormal_lysosome_morphology0.99536618
93MP0002269_muscular_atrophy0.99407172
94MP0004859_abnormal_synaptic_plasticity0.98461579
95MP0009642_abnormal_blood_homeostasis0.98037355
96MP0009763_increased_sensitivity_to0.95540900
97MP0005621_abnormal_cell_physiology0.95290264
98MP0003724_increased_susceptibility_to0.94620808
99MP0003221_abnormal_cardiomyocyte_apopto0.94284944
100MP0003300_gastrointestinal_ulcer0.92397989
101MP0002075_abnormal_coat/hair_pigmentati0.91864186
102MP0008469_abnormal_protein_level0.91819621
103MP0001545_abnormal_hematopoietic_system0.88986113
104MP0005397_hematopoietic_system_phenotyp0.88986113
105MP0003634_abnormal_glial_cell0.88482949
106MP0003011_delayed_dark_adaptation0.88447690
107MP0003953_abnormal_hormone_level0.88401730
108MP0002837_dystrophic_cardiac_calcinosis0.87167587
109MP0003868_abnormal_feces_composition0.85690367
110MP0002136_abnormal_kidney_physiology0.85363009
111MP0002796_impaired_skin_barrier0.85226409
112MP0000604_amyloidosis0.85197129
113MP0005384_cellular_phenotype0.85184935
114MP0009053_abnormal_anal_canal0.84940179
115MP0004087_abnormal_muscle_fiber0.82598241
116MP0005451_abnormal_body_composition0.81332924
117MP0003172_abnormal_lysosome_physiology0.80908854
118MP0000858_altered_metastatic_potential0.80525799
119MP0005220_abnormal_exocrine_pancreas0.80473229
120MP0001672_abnormal_embryogenesis/_devel0.80245308
121MP0005380_embryogenesis_phenotype0.80245308
122MP0000372_irregular_coat_pigmentation0.80085792
123MP0009765_abnormal_xenobiotic_induced0.78381869
124MP0002909_abnormal_adrenal_gland0.78234400
125MP0001186_pigmentation_phenotype0.77782027
126MP0002876_abnormal_thyroid_physiology0.76903535
127MP0002396_abnormal_hematopoietic_system0.76750050
128MP0001944_abnormal_pancreas_morphology0.76332074
129MP0002166_altered_tumor_susceptibility0.75748131
130MP0002019_abnormal_tumor_incidence0.72924977
131MP0004510_myositis0.71600727
132MP0000749_muscle_degeneration0.71319475
133MP0001727_abnormal_embryo_implantation0.70945159
134MP0001188_hyperpigmentation0.70650057
135MP0005376_homeostasis/metabolism_phenot0.69605653
136MP0008872_abnormal_physiological_respon0.69569671
137MP0002138_abnormal_hepatobiliary_system0.69257271
138MP0006054_spinal_hemorrhage0.68627962
139MP0003786_premature_aging0.67292269
140MP0001853_heart_inflammation0.66885897
141MP0003329_amyloid_beta_deposits0.66298115
142MP0005266_abnormal_metabolism0.65714010
143MP0001765_abnormal_ion_homeostasis0.63933285
144MP0000230_abnormal_systemic_arterial0.63919086
145MP0001697_abnormal_embryo_size0.62230512
146MP0009672_abnormal_birth_weight0.61789944
147MP0010234_abnormal_vibrissa_follicle0.61664014
148MP0003984_embryonic_growth_retardation0.60949843
149MP0000733_abnormal_muscle_development0.60129906
150MP0005275_abnormal_skin_tensile0.58865974
151MP0010630_abnormal_cardiac_muscle0.58768434
152MP0005423_abnormal_somatic_nervous0.58677959
153MP0003303_peritoneal_inflammation0.58632142
154MP0008569_lethality_at_weaning0.58333677
155MP0002085_abnormal_embryonic_tissue0.57744908
156MP0002254_reproductive_system_inflammat0.57275807
157MP0000685_abnormal_immune_system0.56894258
158MP0000358_abnormal_cell_content/0.56636416
159MP0008874_decreased_physiological_sensi0.56038700
160MP0000371_diluted_coat_color0.55912582
161MP0000343_altered_response_to0.55113695
162MP0005330_cardiomyopathy0.54972164
163MP0001881_abnormal_mammary_gland0.53442652
164MP0005084_abnormal_gallbladder_morpholo0.49254704
165MP0008873_increased_physiological_sensi0.48994471
166MP0005464_abnormal_platelet_physiology0.48816552
167MP0003690_abnormal_glial_cell0.46854965
168MP0002089_abnormal_postnatal_growth/wei0.46584743
169MP0000747_muscle_weakness0.45652998
170MP0003763_abnormal_thymus_physiology0.45533739
171MP0002135_abnormal_kidney_morphology0.44687218
172MP0009333_abnormal_splenocyte_physiolog0.41081398
173MP0008775_abnormal_heart_ventricle0.40919991
174MP0009764_decreased_sensitivity_to0.40530173

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)5.44657973
2Hypoglycemic coma (HP:0001325)5.23738576
3Abnormality of fatty-acid metabolism (HP:0004359)5.02532028
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.96708082
5Abnormality of serine family amino acid metabolism (HP:0010894)4.82572547
6Abnormality of glycine metabolism (HP:0010895)4.82572547
7Ketosis (HP:0001946)4.70426110
8Hyperammonemia (HP:0001987)4.58600240
9Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.45291925
10Ketoacidosis (HP:0001993)4.41057537
11Abnormality of dicarboxylic acid metabolism (HP:0010995)4.20601415
12Dicarboxylic aciduria (HP:0003215)4.20601415
13Xanthomatosis (HP:0000991)4.12431970
14Progressive muscle weakness (HP:0003323)4.04236548
15Generalized aminoaciduria (HP:0002909)3.96377056
16Hyperglycinemia (HP:0002154)3.92236832
17Microvesicular hepatic steatosis (HP:0001414)3.73486636
18Hyperlipoproteinemia (HP:0010980)3.63165036
19Increased muscle lipid content (HP:0009058)3.62591877
20Deep venous thrombosis (HP:0002625)3.55992882
21Vertebral compression fractures (HP:0002953)3.52460237
22Hepatic necrosis (HP:0002605)3.50218950
23Myoglobinuria (HP:0002913)3.44175806
24Myopathic facies (HP:0002058)3.41160302
25Complement deficiency (HP:0004431)3.39796432
26Broad distal phalanx of finger (HP:0009836)3.37530959
27Intrahepatic cholestasis (HP:0001406)3.37041412
28Oligomenorrhea (HP:0000876)3.36951066
29Abnormality of glutamine family amino acid metabolism (HP:0010902)3.35247894
30Hypertriglyceridemia (HP:0002155)3.23224828
31Abnormality of monocarboxylic acid metabolism (HP:0010996)3.17389254
32Nausea (HP:0002018)3.16981888
33Hypobetalipoproteinemia (HP:0003563)3.03483723
34Rhabdomyolysis (HP:0003201)3.02556374
35Hyperacusis (HP:0010780)3.00654097
36Centrally nucleated skeletal muscle fibers (HP:0003687)2.96998597
37Lethargy (HP:0001254)2.91685164
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.91356608
39Proximal tubulopathy (HP:0000114)2.88507372
40Epidermoid cyst (HP:0200040)2.86370157
41Hypoglycemic seizures (HP:0002173)2.85775549
42Stridor (HP:0010307)2.83320774
43Achilles tendon contracture (HP:0001771)2.82915221
44Hypoalphalipoproteinemia (HP:0003233)2.80239643
45Abnormality of proline metabolism (HP:0010907)2.75381127
46Hydroxyprolinuria (HP:0003080)2.75381127
47Metabolic acidosis (HP:0001942)2.75079526
48Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.74822069
49Hypolipoproteinemia (HP:0010981)2.74773850
50Brushfield spots (HP:0001088)2.71447307
51Late onset (HP:0003584)2.68546070
52Abnormality of serum amino acid levels (HP:0003112)2.66746560
53Testicular atrophy (HP:0000029)2.65487355
54Abnormality of purine metabolism (HP:0004352)2.64534485
55Hyperbilirubinemia (HP:0002904)2.64301645
56Cerebral edema (HP:0002181)2.58762084
57Delayed CNS myelination (HP:0002188)2.57268779
58Prolonged partial thromboplastin time (HP:0003645)2.55663344
59Progressive external ophthalmoplegia (HP:0000590)2.55341685
60Dysphonia (HP:0001618)2.54556119
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.53132338
62Vomiting (HP:0002013)2.52305713
63Spastic diplegia (HP:0001264)2.51923257
64Abnormality of the common coagulation pathway (HP:0010990)2.51837200
65Multiple enchondromatosis (HP:0005701)2.48435124
66Hepatocellular necrosis (HP:0001404)2.47882468
67Abnormality of the Achilles tendon (HP:0005109)2.47777950
68Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.47637212
69Decreased activity of mitochondrial respiratory chain (HP:0008972)2.47637212
70Pancreatitis (HP:0001733)2.46840172
71Abnormality of nucleobase metabolism (HP:0010932)2.45370761
72Abnormality of complement system (HP:0005339)2.43274334
73Insulin resistance (HP:0000855)2.42756863
74Distal lower limb muscle weakness (HP:0009053)2.42525196
75Limb hypertonia (HP:0002509)2.40022941
76Abnormal cartilage morphology (HP:0002763)2.39209941
77Patent foramen ovale (HP:0001655)2.39004920
78Abnormality of sulfur amino acid metabolism (HP:0004339)2.38435479
79Myocardial infarction (HP:0001658)2.33384669
80Abnormality of liposaccharide metabolism (HP:0010968)2.32547302
81Abnormality of glycosphingolipid metabolism (HP:0004343)2.32547302
82Abnormality of glycolipid metabolism (HP:0010969)2.32547302
83Ragged-red muscle fibers (HP:0003200)2.30392471
84Abnormality of the umbilical cord (HP:0010881)2.30136001
85Gout (HP:0001997)2.29294804
86Abnormality of the intrinsic pathway (HP:0010989)2.28746910
87Hypercholesterolemia (HP:0003124)2.28653737
88Acanthosis nigricans (HP:0000956)2.28565186
89Neuronal loss in central nervous system (HP:0002529)2.25263940
90Lactic acidosis (HP:0003128)2.25237075
91Truncus arteriosus (HP:0001660)2.22997255
92Methylmalonic aciduria (HP:0012120)2.18502358
93Calcaneovalgus deformity (HP:0001848)2.17371113
94Increased serum pyruvate (HP:0003542)2.16569042
95Abnormality of glycolysis (HP:0004366)2.16569042
96Increased cerebral lipofuscin (HP:0011813)2.16475884
97Increased intramyocellular lipid droplets (HP:0012240)2.16393958
98Distal lower limb amyotrophy (HP:0008944)2.16046150
99Upper limb amyotrophy (HP:0009129)2.15438893
100Distal upper limb amyotrophy (HP:0007149)2.15438893
101Acute encephalopathy (HP:0006846)2.14577774
102Annular pancreas (HP:0001734)2.14231351
103Trismus (HP:0000211)2.13697251
104Abnormality of the anterior horn cell (HP:0006802)2.07767721
105Degeneration of anterior horn cells (HP:0002398)2.07767721
106Insomnia (HP:0100785)2.07517676
107Symptomatic seizures (HP:0011145)2.07089911
108Abnormality of pyrimidine metabolism (HP:0004353)2.07043313
109Abnormality of urine glucose concentration (HP:0011016)2.05803354
110Glycosuria (HP:0003076)2.05803354
111Microretrognathia (HP:0000308)2.03241539
112Abnormality of skeletal muscle fiber size (HP:0012084)2.02803849
113Elevated hepatic transaminases (HP:0002910)2.02461518
114Epiphyseal stippling (HP:0010655)2.01830418
115Growth hormone excess (HP:0000845)2.01155795
116Irritability (HP:0000737)2.01109569
117Generalized amyotrophy (HP:0003700)2.00829012
118Ankle clonus (HP:0011448)1.99746551
119Renal cortical cysts (HP:0000803)1.99705984
120Fasciculations (HP:0002380)1.98665165
121Back pain (HP:0003418)1.98547873
122Skin nodule (HP:0200036)1.97820864
123Cholelithiasis (HP:0001081)1.95100865
124Neonatal onset (HP:0003623)1.94967212
125Exercise-induced myalgia (HP:0003738)1.92779130
126Cholecystitis (HP:0001082)1.92400966
127Abnormal gallbladder physiology (HP:0012438)1.92400966
128Thin bony cortex (HP:0002753)1.92220924
129Abnormality of the heme biosynthetic pathway (HP:0010472)1.92218120
130Increased purine levels (HP:0004368)1.90645631
131Hyperuricemia (HP:0002149)1.90645631
132CNS demyelination (HP:0007305)1.89252457
133Conjunctival hamartoma (HP:0100780)1.88491887
134Hyperthyroidism (HP:0000836)1.88078966
135Ulnar bowing (HP:0003031)1.87704308
136Opisthotonus (HP:0002179)1.87274461
137Cerebral hypomyelination (HP:0006808)1.86711370
138Overriding aorta (HP:0002623)1.86639168
139Increased variability in muscle fiber diameter (HP:0003557)1.86404927
140Increased neuronal autofluorescent lipopigment (HP:0002074)1.86240378
141Hand muscle atrophy (HP:0009130)1.85023808
142Hepatocellular carcinoma (HP:0001402)1.84395652
143Systemic lupus erythematosus (HP:0002725)1.83365739
144Biconcave vertebral bodies (HP:0004586)1.82041705
145Fat malabsorption (HP:0002630)1.81998051
146Abnormality of methionine metabolism (HP:0010901)1.80849523
147Short nail (HP:0001799)1.79341984
148Bulbar palsy (HP:0001283)1.76965875
149Neoplasm of the adrenal gland (HP:0100631)1.76560131
150Increased serum ferritin (HP:0003281)1.75874039
151Tachypnea (HP:0002789)1.75800085
152Spinal cord lesions (HP:0100561)1.75483168
153Syringomyelia (HP:0003396)1.75483168
154Difficulty climbing stairs (HP:0003551)1.75259535
155Visual hallucinations (HP:0002367)1.74635371
156Joint hemorrhage (HP:0005261)1.74189926
157Mitral regurgitation (HP:0001653)1.74158272
158Nemaline bodies (HP:0003798)1.74138012
159Loss of speech (HP:0002371)1.72777557
160Increased connective tissue (HP:0009025)1.71895710
161Lower limb amyotrophy (HP:0007210)1.71013618
162Hypertensive crisis (HP:0100735)1.70767604
163Tetraplegia (HP:0002445)1.70572626
164Selective tooth agenesis (HP:0001592)1.69795874
165Pointed chin (HP:0000307)1.69250748
166Obstructive sleep apnea (HP:0002870)1.68921807
167Partial duplication of thumb phalanx (HP:0009944)1.68499705
168Abnormal umbilical cord blood vessels (HP:0011403)1.68438215
169Single umbilical artery (HP:0001195)1.68438215
170Abnormality of the fetal cardiovascular system (HP:0010948)1.68438215
171Deformed tarsal bones (HP:0008119)1.66535236
172Microglossia (HP:0000171)1.66521095
173Supranuclear gaze palsy (HP:0000605)1.66417686
174Purpura (HP:0000979)1.65832760
175Abnormality of the calcaneus (HP:0008364)1.65785846
176Muscle fiber inclusion bodies (HP:0100299)1.65075162
177Myokymia (HP:0002411)1.64949746
178Reticulocytopenia (HP:0001896)1.64363079
179Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.63687661
180Upper motor neuron abnormality (HP:0002127)1.63658513
181Rough bone trabeculation (HP:0100670)1.62297655
182External ophthalmoplegia (HP:0000544)1.61069502
183Abnormality of the gallbladder (HP:0005264)1.60906408
184Depression (HP:0000716)1.60781868
185Muscle stiffness (HP:0003552)1.60755249
186Abnormal ventriculo-arterial connection (HP:0011563)1.58197830
187Transposition of the great arteries (HP:0001669)1.58197830
188Abnormal connection of the cardiac segments (HP:0011545)1.58197830
189Abnormal gallbladder morphology (HP:0012437)1.58180451
190Exercise intolerance (HP:0003546)1.58127021
191Polygenic inheritance (HP:0010982)1.56419037

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.68553562
2TRIB35.01941537
3SMG13.93485706
4PKN23.66370948
5ERN13.38788680
6SIK13.30945465
7PRPF4B2.91279991
8CAMK1D2.87332182
9FLT32.66158753
10SCYL22.29382469
11FGFR42.12893623
12IRAK32.12869807
13CDC72.12746927
14VRK22.09617648
15PRKD31.94597633
16MAP4K11.86203509
17NME21.82441006
18PDK31.75670842
19PDK41.75670842
20ARAF1.75114920
21MAP3K101.69014526
22NEK11.65944763
23LRRK21.64574419
24TNK21.62932752
25ICK1.57443425
26EEF2K1.56762948
27STK161.54369863
28PBK1.45210007
29CAMK1G1.45005873
30KDR1.38405087
31PTK61.38124768
32DAPK11.34612380
33MAP3K111.31645091
34MAP2K31.29358334
35ZAP701.28402196
36LIMK11.26589341
37PAK61.25568948
38TGFBR21.23988253
39TTN1.23834617
40AURKA1.21109047
41MAPK111.21015113
42LMTK21.19985930
43TYK21.13325990
44BRAF1.13194859
45CDK71.10499830
46GRK61.04783439
47CDK191.03611097
48CDK11A0.96246029
49JAK30.93636436
50TESK20.93094256
51CDK40.92484894
52CDK150.91387210
53LATS20.89120308
54TTK0.88915091
55TBK10.87797982
56JAK20.86716637
57TAF10.85904907
58PRKD20.85851936
59CDK140.85256183
60CDK180.83636788
61ATR0.83502350
62WEE10.82811550
63CDK60.80314040
64BTK0.78643907
65CDK80.78303499
66DAPK20.77713562
67CAMKK20.76332188
68TGFBR10.73927675
69WNK30.72966707
70NEK20.71851073
71CAMK2G0.70133147
72CSF1R0.69437767
73AURKB0.67309223
74PDGFRA0.67260835
75ITK0.67004861
76TESK10.66581660
77MAPKAPK30.66364188
78CDK90.65924295
79MAPK120.63814611
80ALK0.63374734
81WNK40.61897652
82PRKAA20.61298274
83DMPK0.60199950
84RIPK10.59967553
85CHEK20.59900645
86JAK10.59190244
87PASK0.58470371
88PLK10.58253075
89ABL20.58078430
90MAP3K10.57940619
91MAP2K10.57873059
92BMX0.57850431
93PAK10.57641478
94IRAK20.57631608
95MAPK40.57559458
96MOS0.56242239
97ACVR1B0.55215991
98FGFR20.52684469
99DYRK1B0.52130814
100EIF2AK30.52075479
101NEK90.51462045
102CDK120.50590352
103PDK10.48440006
104PDPK10.47774062
105MST1R0.47762385
106CHEK10.47429580
107BRSK10.46861129
108BRSK20.46654641
109MAP3K80.46458744
110PRKAA10.44420611
111TAOK20.43766172
112MTOR0.43538780
113EIF2AK10.43197576
114TAOK10.42818226
115RET0.42809618
116KIT0.42155099
117ILK0.42137747
118PRKACG0.42112736
119BUB10.41965080
120CAMK2B0.40367712
121PAK20.39489804
122MAP3K70.39089637
123SYK0.38999292
124RPS6KL10.37814383
125RPS6KC10.37814383
126SRPK10.37283617
127MAP3K30.37090546
128CDK20.36355325
129GSK3A0.35209308
130RAF10.34510073
131STK100.33601878
132AKT20.33147464
133PIK3CG0.32986615
134PAK40.32836597
135RPS6KA40.32497549
136KSR20.32480026
137UHMK10.32349537
138CAMKK10.31909154
139PINK10.31066386
140MARK20.30692819
141INSRR0.30656110
142CAMK2D0.30462806
143CAMK10.29943660
144PIM20.29913083
145RPS6KB20.29772165
146MAP2K20.29546735
147PRKG20.28119002
148PRKCH0.26985642
149HIPK20.26114243
150DAPK30.24823241

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.81643934
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.61428575
3Fatty acid degradation_Homo sapiens_hsa000713.51769569
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.42855812
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.09157451
6Fatty acid metabolism_Homo sapiens_hsa012123.05523889
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.03837642
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.79006776
9PPAR signaling pathway_Homo sapiens_hsa033202.76854482
10Pyruvate metabolism_Homo sapiens_hsa006202.45778958
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.45548876
12Butanoate metabolism_Homo sapiens_hsa006502.26835960
13Carbon metabolism_Homo sapiens_hsa012002.25417624
14Nitrogen metabolism_Homo sapiens_hsa009102.23358085
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.22427321
16Tryptophan metabolism_Homo sapiens_hsa003802.21512562
17Peroxisome_Homo sapiens_hsa041462.16486844
18beta-Alanine metabolism_Homo sapiens_hsa004101.97944563
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.95105613
20Fatty acid elongation_Homo sapiens_hsa000621.82574622
21Other glycan degradation_Homo sapiens_hsa005111.73631255
22Arginine biosynthesis_Homo sapiens_hsa002201.71240335
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68517372
24Fatty acid biosynthesis_Homo sapiens_hsa000611.68066573
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.68063091
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.58243710
27Biosynthesis of amino acids_Homo sapiens_hsa012301.56218602
28Folate biosynthesis_Homo sapiens_hsa007901.52600006
29Spliceosome_Homo sapiens_hsa030401.51106364
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48053045
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41916838
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41701550
33Glycerolipid metabolism_Homo sapiens_hsa005611.32193911
34Caffeine metabolism_Homo sapiens_hsa002321.28559533
35Sulfur relay system_Homo sapiens_hsa041221.27689635
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26679304
37* Drug metabolism - other enzymes_Homo sapiens_hsa009831.26277045
38Pentose phosphate pathway_Homo sapiens_hsa000301.25222632
39Selenocompound metabolism_Homo sapiens_hsa004501.23366594
40Cell cycle_Homo sapiens_hsa041101.22778827
41Fat digestion and absorption_Homo sapiens_hsa049751.19701588
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18113202
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.17821333
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16043730
45Phenylalanine metabolism_Homo sapiens_hsa003601.14472515
46Complement and coagulation cascades_Homo sapiens_hsa046101.13580442
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.11613809
48Vibrio cholerae infection_Homo sapiens_hsa051101.10829129
49Non-homologous end-joining_Homo sapiens_hsa034501.08951720
50Homologous recombination_Homo sapiens_hsa034401.07413272
51Starch and sucrose metabolism_Homo sapiens_hsa005001.05905869
52Sulfur metabolism_Homo sapiens_hsa009201.04084759
53Nucleotide excision repair_Homo sapiens_hsa034201.03940626
54Tyrosine metabolism_Homo sapiens_hsa003501.03522571
55Synaptic vesicle cycle_Homo sapiens_hsa047211.00712025
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00407149
57Chemical carcinogenesis_Homo sapiens_hsa052041.00316958
58Lysine degradation_Homo sapiens_hsa003100.98094959
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.97115476
60Lysosome_Homo sapiens_hsa041420.96817005
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.96515039
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95065898
63RNA polymerase_Homo sapiens_hsa030200.92976215
64Histidine metabolism_Homo sapiens_hsa003400.92262576
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92141213
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91700339
67Non-small cell lung cancer_Homo sapiens_hsa052230.91143844
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90938143
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86996367
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86410278
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85960016
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85023980
73Bile secretion_Homo sapiens_hsa049760.83208451
74Chronic myeloid leukemia_Homo sapiens_hsa052200.83051785
75DNA replication_Homo sapiens_hsa030300.78877313
76Notch signaling pathway_Homo sapiens_hsa043300.75334342
77Glutathione metabolism_Homo sapiens_hsa004800.75054647
78RNA transport_Homo sapiens_hsa030130.73402099
79Fanconi anemia pathway_Homo sapiens_hsa034600.72677053
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.72516103
81ABC transporters_Homo sapiens_hsa020100.72096196
82AMPK signaling pathway_Homo sapiens_hsa041520.69281761
83Retinol metabolism_Homo sapiens_hsa008300.68831205
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.67823757
85One carbon pool by folate_Homo sapiens_hsa006700.66969760
86Staphylococcus aureus infection_Homo sapiens_hsa051500.65845729
87Purine metabolism_Homo sapiens_hsa002300.65354215
88mRNA surveillance pathway_Homo sapiens_hsa030150.61404467
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60456966
90Insulin resistance_Homo sapiens_hsa049310.60263313
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59900798
92* Metabolic pathways_Homo sapiens_hsa011000.56637929
93Arginine and proline metabolism_Homo sapiens_hsa003300.53841500
94Galactose metabolism_Homo sapiens_hsa000520.53725193
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53454412
96Fructose and mannose metabolism_Homo sapiens_hsa000510.53252562
97Pancreatic cancer_Homo sapiens_hsa052120.51606536
98Epstein-Barr virus infection_Homo sapiens_hsa051690.50900669
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49482579
100Glucagon signaling pathway_Homo sapiens_hsa049220.47155425
101HTLV-I infection_Homo sapiens_hsa051660.46501594
102Insulin signaling pathway_Homo sapiens_hsa049100.45160297
103Ribosome_Homo sapiens_hsa030100.44593703
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43653425
105N-Glycan biosynthesis_Homo sapiens_hsa005100.42443921
106Glioma_Homo sapiens_hsa052140.42390354
107Apoptosis_Homo sapiens_hsa042100.41957804
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41817350
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40353970
110Shigellosis_Homo sapiens_hsa051310.39546851
111VEGF signaling pathway_Homo sapiens_hsa043700.39303512
112Endocytosis_Homo sapiens_hsa041440.38922987
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38184701
114Oocyte meiosis_Homo sapiens_hsa041140.36628368
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.36029867
116mTOR signaling pathway_Homo sapiens_hsa041500.35937442
117Parkinsons disease_Homo sapiens_hsa050120.34933767
118Vitamin digestion and absorption_Homo sapiens_hsa049770.33852071
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.32532201
120Base excision repair_Homo sapiens_hsa034100.32134749
121Salmonella infection_Homo sapiens_hsa051320.32005694
122Viral carcinogenesis_Homo sapiens_hsa052030.31651876
123Vitamin B6 metabolism_Homo sapiens_hsa007500.31471583
124Mismatch repair_Homo sapiens_hsa034300.30560874
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28561796
126Endometrial cancer_Homo sapiens_hsa052130.28391064
127p53 signaling pathway_Homo sapiens_hsa041150.27552065
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26971943
129Thyroid cancer_Homo sapiens_hsa052160.26150186
130* Pyrimidine metabolism_Homo sapiens_hsa002400.24528101
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23803954
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.21895957
133Proteasome_Homo sapiens_hsa030500.16366291
134Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15503009
135Oxidative phosphorylation_Homo sapiens_hsa001900.14270137
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12739645
137Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.11383964
138Acute myeloid leukemia_Homo sapiens_hsa052210.08665006
139Renin-angiotensin system_Homo sapiens_hsa046140.04109690
140Huntingtons disease_Homo sapiens_hsa050160.02337439
141Bladder cancer_Homo sapiens_hsa052190.01592892
142Prion diseases_Homo sapiens_hsa050200.01513406
143Alzheimers disease_Homo sapiens_hsa050100.00428124
144Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0523257
145Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0511113
146Protein export_Homo sapiens_hsa03060-0.0034336

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