UBXN2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.71098762
2NADH metabolic process (GO:0006734)5.17436069
3regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.95539540
4intestinal epithelial cell development (GO:0060576)4.86256212
5tricarboxylic acid cycle (GO:0006099)4.55531688
6regulation of acyl-CoA biosynthetic process (GO:0050812)4.52616465
7regulation of translational termination (GO:0006449)4.50128242
8folic acid metabolic process (GO:0046655)4.30218581
9regulation of cofactor metabolic process (GO:0051193)4.18659888
10regulation of coenzyme metabolic process (GO:0051196)4.18659888
11purine nucleobase biosynthetic process (GO:0009113)4.04045982
12sarcoplasmic reticulum calcium ion transport (GO:0070296)3.98438747
13valine metabolic process (GO:0006573)3.93863374
14succinate metabolic process (GO:0006105)3.83451919
15lysine metabolic process (GO:0006553)3.73731782
16lysine catabolic process (GO:0006554)3.73731782
17tricarboxylic acid metabolic process (GO:0072350)3.71539878
18fucose catabolic process (GO:0019317)3.70624475
19L-fucose metabolic process (GO:0042354)3.70624475
20L-fucose catabolic process (GO:0042355)3.70624475
21response to pheromone (GO:0019236)3.68225925
22mitochondrial respiratory chain complex I assembly (GO:0032981)3.61980580
23NADH dehydrogenase complex assembly (GO:0010257)3.61980580
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.61980580
25fatty acid homeostasis (GO:0055089)3.59443791
262-oxoglutarate metabolic process (GO:0006103)3.56464959
27skeletal muscle adaptation (GO:0043501)3.56177203
28Golgi transport vesicle coating (GO:0048200)3.54624697
29COPI coating of Golgi vesicle (GO:0048205)3.54624697
30cysteine metabolic process (GO:0006534)3.54228752
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.53798231
32carnitine shuttle (GO:0006853)3.52360921
33DNA deamination (GO:0045006)3.50536525
34intestinal cholesterol absorption (GO:0030299)3.47414448
35regulation of sulfur metabolic process (GO:0042762)3.46906364
36creatine metabolic process (GO:0006600)3.45242615
37protein neddylation (GO:0045116)3.44884532
38branched-chain amino acid metabolic process (GO:0009081)3.43701627
39purine nucleotide salvage (GO:0032261)3.42252952
40oxaloacetate metabolic process (GO:0006107)3.40140551
41nonmotile primary cilium assembly (GO:0035058)3.38959746
42IMP biosynthetic process (GO:0006188)3.37729815
43kynurenine metabolic process (GO:0070189)3.37122282
44nucleobase biosynthetic process (GO:0046112)3.34343300
45protein complex biogenesis (GO:0070271)3.33822261
46ribosome assembly (GO:0042255)3.33211395
47UDP-N-acetylglucosamine metabolic process (GO:0006047)3.32867157
48COPII vesicle coating (GO:0048208)3.30476347
49IMP metabolic process (GO:0046040)3.28430795
50platelet dense granule organization (GO:0060155)3.27130233
51branched-chain amino acid catabolic process (GO:0009083)3.26093798
52water-soluble vitamin biosynthetic process (GO:0042364)3.26064778
53intestinal absorption (GO:0050892)3.25020728
54fatty acid transmembrane transport (GO:1902001)3.19544703
55mitochondrial respiratory chain complex assembly (GO:0033108)3.18443495
56regulation of nuclear cell cycle DNA replication (GO:0033262)3.18439021
57nucleoside diphosphate biosynthetic process (GO:0009133)3.17909257
58negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.16099988
59pyrimidine nucleobase catabolic process (GO:0006208)3.13602571
60neural tube formation (GO:0001841)3.13110056
61protein-cofactor linkage (GO:0018065)3.12533830
62negative regulation of telomere maintenance (GO:0032205)3.12375381
63indole-containing compound catabolic process (GO:0042436)3.11174952
64indolalkylamine catabolic process (GO:0046218)3.11174952
65tryptophan catabolic process (GO:0006569)3.11174952
66somite development (GO:0061053)3.10436584
67rRNA catabolic process (GO:0016075)3.10195269
68indolalkylamine metabolic process (GO:0006586)3.07448258
69replication fork processing (GO:0031297)3.06241526
70detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.05824923
71oxidative phosphorylation (GO:0006119)3.05698426
72negative regulation of transcription regulatory region DNA binding (GO:2000678)3.05495090
73positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.05207819
74skeletal muscle tissue regeneration (GO:0043403)3.05041980
75folic acid transport (GO:0015884)3.04944724
76aspartate family amino acid catabolic process (GO:0009068)3.03722306
77biotin metabolic process (GO:0006768)3.03282449
78nucleotide-sugar biosynthetic process (GO:0009226)3.00069383
79maturation of 5.8S rRNA (GO:0000460)2.98282492
80reciprocal meiotic recombination (GO:0007131)2.92885850
81reciprocal DNA recombination (GO:0035825)2.92885850
82regulation of hippo signaling (GO:0035330)2.90780493
83epithelial cilium movement (GO:0003351)2.89939194
84recombinational repair (GO:0000725)2.89379474
85double-strand break repair via homologous recombination (GO:0000724)2.87280262
86regulation of cilium movement (GO:0003352)2.84754377
87protein polyglutamylation (GO:0018095)2.84425436
88nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.83470054
89ventricular cardiac muscle cell action potential (GO:0086005)2.77017030
90sulfation (GO:0051923)2.76919035
91negative regulation of DNA-dependent DNA replication (GO:2000104)2.75618722
92exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.75485600
93regulation of mesoderm development (GO:2000380)2.72261654
94regulation of skeletal muscle contraction (GO:0014819)2.72240899
95vitamin transmembrane transport (GO:0035461)2.72052838
96negative regulation of potassium ion transmembrane transport (GO:1901380)2.71973541
97establishment of protein localization to mitochondrial membrane (GO:0090151)2.71089793
98cilium morphogenesis (GO:0060271)2.69789646
99labyrinthine layer development (GO:0060711)2.69359848
100cornea development in camera-type eye (GO:0061303)2.68524100
101detection of light stimulus involved in sensory perception (GO:0050962)2.68511969
102detection of light stimulus involved in visual perception (GO:0050908)2.68511969
103modified amino acid transport (GO:0072337)2.67955364
104ubiquinone biosynthetic process (GO:0006744)2.67567345
105retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.67492387
106meiotic chromosome segregation (GO:0045132)2.67181280
107respiratory chain complex IV assembly (GO:0008535)2.65804258
108protein K6-linked ubiquitination (GO:0085020)2.65492099
109folic acid-containing compound biosynthetic process (GO:0009396)2.64994499
110ubiquinone metabolic process (GO:0006743)2.64289262
111bundle of His cell to Purkinje myocyte communication (GO:0086069)2.63963404
112regulation of mitotic spindle checkpoint (GO:1903504)2.63484152
113regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.63484152
114polyol catabolic process (GO:0046174)2.62689668
115peptide hormone processing (GO:0016486)2.61959519
116striated muscle atrophy (GO:0014891)2.61433354
117protein targeting to Golgi (GO:0000042)2.61360563
118serine family amino acid catabolic process (GO:0009071)2.59631980
119axoneme assembly (GO:0035082)2.59131014
120chromatin remodeling at centromere (GO:0031055)2.58934674
121regulation of translation in response to stress (GO:0043555)2.57665932
122negative regulation of response to food (GO:0032096)2.57287255
123negative regulation of appetite (GO:0032099)2.57287255
124tryptophan metabolic process (GO:0006568)2.56639934
125cellular carbohydrate catabolic process (GO:0044275)2.56639258
126cilium organization (GO:0044782)2.56380911
127skeletal muscle contraction (GO:0003009)2.56002332
128regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.55316095
129behavioral response to ethanol (GO:0048149)2.54979786
130nucleobase catabolic process (GO:0046113)2.54778655
131regulation of Golgi to plasma membrane protein transport (GO:0042996)2.53973455
132mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.53828201
133pseudouridine synthesis (GO:0001522)2.53740164
134respiratory electron transport chain (GO:0022904)2.52955572
135RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.52654538
136L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.52320273
137carnitine transport (GO:0015879)2.51609156
138amino-acid betaine transport (GO:0015838)2.51609156
139response to hydroperoxide (GO:0033194)2.51544034
140cell proliferation in forebrain (GO:0021846)2.51392269
141cellular polysaccharide catabolic process (GO:0044247)2.50443770
142synaptic transmission, cholinergic (GO:0007271)2.50391915
143intracellular lipid transport (GO:0032365)2.50382288
144regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.50151719
145kidney morphogenesis (GO:0060993)2.50007678
146regulation of rhodopsin mediated signaling pathway (GO:0022400)2.49922013
147mannosylation (GO:0097502)2.49921853
148sulfur amino acid biosynthetic process (GO:0000097)2.49223983
149cilium assembly (GO:0042384)2.49215701
150regulation of telomere maintenance (GO:0032204)2.48276985
151negative regulation of translation, ncRNA-mediated (GO:0040033)2.47854439
152regulation of translation, ncRNA-mediated (GO:0045974)2.47854439
153negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.47854439
154fatty acid beta-oxidation (GO:0006635)2.47705246
155digestion (GO:0007586)2.47018048
156transcytosis (GO:0045056)2.46825875
157GDP-mannose metabolic process (GO:0019673)2.46749811
158preassembly of GPI anchor in ER membrane (GO:0016254)2.46375017
159urate metabolic process (GO:0046415)2.46258725
160electron transport chain (GO:0022900)2.45868828
161polysaccharide catabolic process (GO:0000272)2.45726251
162carnitine transmembrane transport (GO:1902603)2.45426805
163negative regulation of NF-kappaB import into nucleus (GO:0042347)2.45061396
164negative regulation of mast cell activation (GO:0033004)2.44486509
165cellular response to glucose starvation (GO:0042149)2.44192310
166actin-myosin filament sliding (GO:0033275)2.43835332
167muscle filament sliding (GO:0030049)2.43835332
168regulation of mitochondrial translation (GO:0070129)2.43573385
169cellular ketone body metabolic process (GO:0046950)2.43268365
170energy coupled proton transport, down electrochemical gradient (GO:0015985)2.42649930
171ATP synthesis coupled proton transport (GO:0015986)2.42649930
172regulation of gene silencing by RNA (GO:0060966)2.42648851
173regulation of posttranscriptional gene silencing (GO:0060147)2.42648851
174regulation of gene silencing by miRNA (GO:0060964)2.42648851
175rhodopsin mediated signaling pathway (GO:0016056)2.41791050
176intraciliary transport (GO:0042073)2.41668780
177retinal ganglion cell axon guidance (GO:0031290)2.41657149
178regulation of helicase activity (GO:0051095)2.40799438
179G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.40395727
180positive regulation of glycolytic process (GO:0045821)2.39953093
181mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.39450394
182CENP-A containing nucleosome assembly (GO:0034080)2.38656253
183CDP-diacylglycerol metabolic process (GO:0046341)2.38308131
184resolution of meiotic recombination intermediates (GO:0000712)2.38274770
185glucan catabolic process (GO:0009251)2.38081564
186interferon-gamma secretion (GO:0072643)2.37299938
187mitotic metaphase plate congression (GO:0007080)2.36571107
188pyrimidine ribonucleoside catabolic process (GO:0046133)2.36095808
189DNA double-strand break processing (GO:0000729)2.35568168
190amine catabolic process (GO:0009310)2.34733001
191cellular biogenic amine catabolic process (GO:0042402)2.34733001
192regulation of sequestering of triglyceride (GO:0010889)2.34060971
193indole-containing compound metabolic process (GO:0042430)2.33988768
194ncRNA catabolic process (GO:0034661)2.33197078
195drug transmembrane transport (GO:0006855)2.33032005
196regulation of glucokinase activity (GO:0033131)2.32906069
197regulation of hexokinase activity (GO:1903299)2.32906069

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.88797660
2ZNF274_21170338_ChIP-Seq_K562_Hela3.86571103
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.82586557
4ZNF263_19887448_ChIP-Seq_K562_Human3.59573455
5E2F7_22180533_ChIP-Seq_HELA_Human3.55264602
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.50699132
7GATA1_22025678_ChIP-Seq_K562_Human3.45341847
8VDR_22108803_ChIP-Seq_LS180_Human3.05234182
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.80903270
10ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.75536825
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.74480423
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.70428421
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.65940652
14GBX2_23144817_ChIP-Seq_PC3_Human2.65772459
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.60046312
16EWS_26573619_Chip-Seq_HEK293_Human2.58523246
17IGF1R_20145208_ChIP-Seq_DFB_Human2.56375570
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.48899187
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48794774
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.44781316
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.43277064
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.35004842
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30887751
24* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.27282661
25FUS_26573619_Chip-Seq_HEK293_Human2.24790764
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21866243
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.20992383
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.18759731
29STAT3_1855785_ChIP-Seq_MESCs_Mouse2.17125294
30TAF15_26573619_Chip-Seq_HEK293_Human2.13695712
31ETS1_20019798_ChIP-Seq_JURKAT_Human2.11725016
32CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08456828
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.05748865
34P300_19829295_ChIP-Seq_ESCs_Human2.02015391
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.98870690
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97695223
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96005267
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.89448799
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89222209
40IRF1_19129219_ChIP-ChIP_H3396_Human1.86885157
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85226129
42VDR_23849224_ChIP-Seq_CD4+_Human1.84343140
43AR_21909140_ChIP-Seq_LNCAP_Human1.83437021
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83393899
45RXR_22158963_ChIP-Seq_LIVER_Mouse1.81724798
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77444098
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76899062
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.76839713
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74484835
50ER_23166858_ChIP-Seq_MCF-7_Human1.72564633
51MYC_18940864_ChIP-ChIP_HL60_Human1.72376846
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.71761643
53ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.69539171
54EST1_17652178_ChIP-ChIP_JURKAT_Human1.66679588
55HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.65095001
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64323525
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64297281
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.64255039
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.62981600
60NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.59246286
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58257023
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.56002949
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.54588887
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54054403
65NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.52317293
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.49243437
67MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48619427
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.48146580
69NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47921079
70* TP53_22573176_ChIP-Seq_HFKS_Human1.47218687
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46878718
72STAT3_23295773_ChIP-Seq_U87_Human1.46487250
73MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45940911
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45626062
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.44979226
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44437648
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43509271
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43377797
79SMAD4_21799915_ChIP-Seq_A2780_Human1.42060181
80GABP_19822575_ChIP-Seq_HepG2_Human1.41961462
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.41800830
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41170868
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40623117
84* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40001881
85SOX2_27498859_Chip-Seq_STOMACH_Mouse1.38882887
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38849125
87AR_25329375_ChIP-Seq_VCAP_Human1.38243100
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37521541
89SOX2_19829295_ChIP-Seq_ESCs_Human1.37317758
90NANOG_19829295_ChIP-Seq_ESCs_Human1.37317758
91TCF4_23295773_ChIP-Seq_U87_Human1.36963238
92TP63_19390658_ChIP-ChIP_HaCaT_Human1.36037691
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35358554
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35077378
95CBP_20019798_ChIP-Seq_JUKART_Human1.35077378
96DCP1A_22483619_ChIP-Seq_HELA_Human1.34662714
97RNF2_27304074_Chip-Seq_NSC_Mouse1.32122065
98ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31214034
99CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30282300
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30215620
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30215620
102LXR_22158963_ChIP-Seq_LIVER_Mouse1.26273410
103PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26001495
104SMAD3_21741376_ChIP-Seq_EPCs_Human1.25766530
105BCAT_22108803_ChIP-Seq_LS180_Human1.25515540
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25072506
107SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25000511
108EZH2_27294783_Chip-Seq_NPCs_Mouse1.23038593
109CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22820660
110ATF3_27146783_Chip-Seq_COLON_Human1.22462811
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21010167
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20902200
113SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.20546998
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18208499
115TCF4_22108803_ChIP-Seq_LS180_Human1.17963688
116TFEB_21752829_ChIP-Seq_HELA_Human1.17403055
117GATA4_25053715_ChIP-Seq_YYC3_Human1.17106368
118NFE2_27457419_Chip-Seq_LIVER_Mouse1.16402568
119TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14360236
120PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14031531
121SRF_21415370_ChIP-Seq_HL-1_Mouse1.13949803
122GATA6_25053715_ChIP-Seq_YYC3_Human1.13653215
123OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13179326
124SMAD4_21741376_ChIP-Seq_EPCs_Human1.12975050
125E2F1_21310950_ChIP-Seq_MCF-7_Human1.11856698
126RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11788384
127ELK1_19687146_ChIP-ChIP_HELA_Human1.11749544
128FOXA1_25329375_ChIP-Seq_VCAP_Human1.11574666
129FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11574666
130KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11339407
131FOXP3_21729870_ChIP-Seq_TREG_Human1.10688346
132RUNX2_22187159_ChIP-Seq_PCA_Human1.10255943
133TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09085404
134KDM5A_27292631_Chip-Seq_BREAST_Human1.08420066
135* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08047556
136SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07907498
137FLI1_21867929_ChIP-Seq_TH2_Mouse1.06991584
138TP53_16413492_ChIP-PET_HCT116_Human1.06047754
139FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.05045057
140HOXB7_26014856_ChIP-Seq_BT474_Human1.04770803
141* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03833121
142FLI1_27457419_Chip-Seq_LIVER_Mouse1.03777047
143GATA3_21878914_ChIP-Seq_MCF-7_Human1.03577809
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03437726
145SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03040965
146AR_20517297_ChIP-Seq_VCAP_Human1.02446246
147SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02255536
148CHD1_26751641_Chip-Seq_LNCaP_Human1.02180111
149KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02076479
150CRX_20693478_ChIP-Seq_RETINA_Mouse1.01552011
151P53_22387025_ChIP-Seq_ESCs_Mouse1.00870048
152ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00784802
153NANOG_18555785_Chip-Seq_ESCs_Mouse1.00438643
154JUN_21703547_ChIP-Seq_K562_Human1.00023585
155KAP1_27257070_Chip-Seq_ESCs_Mouse0.99082999
156* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98640672
157SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98238171
158CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97662148
159CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96763538
160* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.96453874
161PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96324088
162FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95894784
163NANOG_18692474_ChIP-Seq_MEFs_Mouse0.95404559
164FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95392649
165GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.94206579
166* NCOR_22424771_ChIP-Seq_293T_Human0.93940112
167ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93889761
168ESR2_21235772_ChIP-Seq_MCF-7_Human0.93820385
169EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93425695
170STAT3_18555785_Chip-Seq_ESCs_Mouse0.92457960
171E2F1_18555785_Chip-Seq_ESCs_Mouse0.92307505
172NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92121710
173KAP1_22055183_ChIP-Seq_ESCs_Mouse0.91178184
174NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.90851181
175AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90044314
176FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.89759817
177EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89330041
178NANOG_18692474_ChIP-Seq_MESCs_Mouse0.88441183
179TCF3_18692474_ChIP-Seq_MESCs_Mouse0.86697721
180NANOG_21062744_ChIP-ChIP_HESCs_Human0.86426095
181OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86035182
182SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85881752
183GATA3_24758297_ChIP-Seq_MCF-7_Human0.85417863
184CDX2_22108803_ChIP-Seq_LS180_Human0.84216026
185SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.83235492
186YY1_21170310_ChIP-Seq_MESCs_Mouse0.82313310
187SOX2_18692474_ChIP-Seq_MEFs_Mouse0.81479886
188HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.80761036
189YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80360398
190E2F4_17652178_ChIP-ChIP_JURKAT_Human0.80238595

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.02618205
2MP0004043_abnormal_pH_regulation3.29952561
3MP0002837_dystrophic_cardiac_calcinosis3.22712717
4MP0006292_abnormal_olfactory_placode2.83970436
5MP0010234_abnormal_vibrissa_follicle2.71842904
6MP0003806_abnormal_nucleotide_metabolis2.68149617
7MP0003136_yellow_coat_color2.61516077
8MP0002102_abnormal_ear_morphology2.57019538
9MP0002139_abnormal_hepatobiliary_system2.50162073
10MP0002877_abnormal_melanocyte_morpholog2.48061006
11MP0006036_abnormal_mitochondrial_physio2.45932476
12MP0004145_abnormal_muscle_electrophysio2.43548514
13MP0003693_abnormal_embryo_hatching2.41446371
14MP0001666_abnormal_nutrient_absorption2.37520824
15MP0004130_abnormal_muscle_cell2.30962246
16MP0005085_abnormal_gallbladder_physiolo2.27738412
17MP0004036_abnormal_muscle_relaxation2.24957964
18MP0002938_white_spotting2.24196225
19MP0000569_abnormal_digit_pigmentation2.22857435
20MP0002138_abnormal_hepatobiliary_system2.19730473
21MP0005360_urolithiasis2.15827080
22MP0005551_abnormal_eye_electrophysiolog2.07882324
23MP0004215_abnormal_myocardial_fiber2.06329271
24MP0003890_abnormal_embryonic-extraembry2.02773240
25MP0003195_calcinosis2.02238905
26MP0003011_delayed_dark_adaptation2.00556811
27MP0002234_abnormal_pharynx_morphology1.97326759
28MP0000013_abnormal_adipose_tissue1.95450729
29MP0000372_irregular_coat_pigmentation1.95405068
30MP0005645_abnormal_hypothalamus_physiol1.94534510
31MP0002693_abnormal_pancreas_physiology1.93785295
32MP0008877_abnormal_DNA_methylation1.91889911
33MP0005365_abnormal_bile_salt1.91799636
34MP0006072_abnormal_retinal_apoptosis1.88354990
35MP0001968_abnormal_touch/_nociception1.87406041
36MP0004084_abnormal_cardiac_muscle1.85770228
37MP0002736_abnormal_nociception_after1.85708999
38MP0000747_muscle_weakness1.84119057
39MP0004147_increased_porphyrin_level1.82252512
40MP0004142_abnormal_muscle_tone1.81579046
41MP0004264_abnormal_extraembryonic_tissu1.81280407
42MP0000749_muscle_degeneration1.79935186
43MP0005253_abnormal_eye_physiology1.76870598
44MP0000631_abnormal_neuroendocrine_gland1.76033083
45MP0005332_abnormal_amino_acid1.75364132
46MP0002653_abnormal_ependyma_morphology1.73804816
47MP0002269_muscular_atrophy1.73592853
48MP0006276_abnormal_autonomic_nervous1.71813586
49MP0001529_abnormal_vocalization1.70429167
50MP0005083_abnormal_biliary_tract1.60066807
51MP0004133_heterotaxia1.58796666
52MP0002078_abnormal_glucose_homeostasis1.58370982
53MP0001293_anophthalmia1.55572447
54MP0005666_abnormal_adipose_tissue1.55185989
55MP0008058_abnormal_DNA_repair1.53104351
56MP0002106_abnormal_muscle_physiology1.52234261
57MP0006035_abnormal_mitochondrial_morpho1.51541436
58MP0009046_muscle_twitch1.51441817
59MP0002909_abnormal_adrenal_gland1.50920894
60MP0003937_abnormal_limbs/digits/tail_de1.50376265
61MP0009643_abnormal_urine_homeostasis1.49841392
62MP0004957_abnormal_blastocyst_morpholog1.49548646
63MP0003718_maternal_effect1.48200365
64MP0004185_abnormal_adipocyte_glucose1.46704243
65MP0003656_abnormal_erythrocyte_physiolo1.45178238
66MP0003880_abnormal_central_pattern1.45133397
67MP0004885_abnormal_endolymph1.44918931
68MP0001485_abnormal_pinna_reflex1.44399176
69MP0005620_abnormal_muscle_contractility1.44076413
70MP0005379_endocrine/exocrine_gland_phen1.42707737
71MP0005535_abnormal_body_temperature1.41924079
72MP0005646_abnormal_pituitary_gland1.41886332
73MP0003221_abnormal_cardiomyocyte_apopto1.40532972
74MP0005330_cardiomyopathy1.40270655
75MP0005174_abnormal_tail_pigmentation1.34403151
76MP0000778_abnormal_nervous_system1.34005529
77MP0005266_abnormal_metabolism1.32925195
78MP0009840_abnormal_foam_cell1.31941616
79MP0002971_abnormal_brown_adipose1.30992438
80MP0000427_abnormal_hair_cycle1.30026451
81MP0002009_preneoplasia1.29500890
82MP0003119_abnormal_digestive_system1.28588892
83MP0005636_abnormal_mineral_homeostasis1.28528175
84MP0004019_abnormal_vitamin_homeostasis1.27372803
85MP0009745_abnormal_behavioral_response1.27011186
86MP0003252_abnormal_bile_duct1.26865180
87MP0000751_myopathy1.26559612
88MP0000049_abnormal_middle_ear1.26417250
89MP0000003_abnormal_adipose_tissue1.25722059
90MP0004087_abnormal_muscle_fiber1.23840973
91MP0001944_abnormal_pancreas_morphology1.23356078
92MP0005375_adipose_tissue_phenotype1.23063488
93MP0002332_abnormal_exercise_endurance1.22982865
94MP0005220_abnormal_exocrine_pancreas1.22567118
95MP0002095_abnormal_skin_pigmentation1.22439384
96MP0008789_abnormal_olfactory_epithelium1.22431310
97MP0001765_abnormal_ion_homeostasis1.22013721
98MP0005195_abnormal_posterior_eye1.20732844
99MP0002160_abnormal_reproductive_system1.20336699
100MP0001986_abnormal_taste_sensitivity1.19638637
101MP0005389_reproductive_system_phenotype1.19508972
102MP0002163_abnormal_gland_morphology1.16797958
103MP0003787_abnormal_imprinting1.16673659
104MP0000609_abnormal_liver_physiology1.16349777
105MP0005171_absent_coat_pigmentation1.15710930
106MP0002118_abnormal_lipid_homeostasis1.15687681
107MP0008961_abnormal_basal_metabolism1.15611082
108MP0001764_abnormal_homeostasis1.15075909
109MP0002272_abnormal_nervous_system1.14751845
110MP0000383_abnormal_hair_follicle1.13912859
111MP0005319_abnormal_enzyme/_coenzyme1.12007096
112MP0002751_abnormal_autonomic_nervous1.11967426
113MP0008775_abnormal_heart_ventricle1.11517368
114MP0005187_abnormal_penis_morphology1.10579978
115MP0003186_abnormal_redox_activity1.09858860
116MP0001984_abnormal_olfaction1.08924650
117MP0000750_abnormal_muscle_regeneration1.08595793
118MP0005310_abnormal_salivary_gland1.07836398
119MP0001919_abnormal_reproductive_system1.07798535
120MP0005369_muscle_phenotype1.06405181
121MP0001486_abnormal_startle_reflex1.06089217
122MP0005167_abnormal_blood-brain_barrier1.05439016
123MP0004924_abnormal_behavior1.05373284
124MP0005386_behavior/neurological_phenoty1.05373284
125MP0002557_abnormal_social/conspecific_i1.04094258
126MP0002876_abnormal_thyroid_physiology1.03223716
127MP0000647_abnormal_sebaceous_gland1.02955486
128MP0000566_synostosis1.02487307
129MP0002752_abnormal_somatic_nervous1.02401462
130MP0002067_abnormal_sensory_capabilities1.01100682
131MP0002735_abnormal_chemical_nociception0.99949337
132MP0005084_abnormal_gallbladder_morpholo0.99367196
133MP0001881_abnormal_mammary_gland0.99004514
134MP0002972_abnormal_cardiac_muscle0.98925926
135MP0005391_vision/eye_phenotype0.98229161
136MP0001756_abnormal_urination0.96746217
137MP0001286_abnormal_eye_development0.95578964
138MP0002572_abnormal_emotion/affect_behav0.94453593
139MP0003868_abnormal_feces_composition0.93881584
140MP0001324_abnormal_eye_pigmentation0.93674622
141MP0010386_abnormal_urinary_bladder0.93446081
142MP0000026_abnormal_inner_ear0.93022119
143MP0002233_abnormal_nose_morphology0.91578426
144MP0010352_gastrointestinal_tract_polyps0.90775191
145MP0002184_abnormal_innervation0.90639412
146MP0000759_abnormal_skeletal_muscle0.89680952
147MP0005448_abnormal_energy_balance0.88446789
148MP0009697_abnormal_copulation0.87818148
149MP0003137_abnormal_impulse_conducting0.87814606
150MP0004742_abnormal_vestibular_system0.87126324
151MP0002733_abnormal_thermal_nociception0.86007592
152MP0010094_abnormal_chromosome_stability0.85666471
153MP0005334_abnormal_fat_pad0.85509446
154MP0001661_extended_life_span0.84301586
155MP0000230_abnormal_systemic_arterial0.83814960
156MP0001970_abnormal_pain_threshold0.83245609
157MP0003121_genomic_imprinting0.83164301
158MP0005394_taste/olfaction_phenotype0.82926806
159MP0005499_abnormal_olfactory_system0.82926806
160MP0004484_altered_response_of0.82543338
161MP0003567_abnormal_fetal_cardiomyocyte0.82440474
162MP0004233_abnormal_muscle_weight0.82291144
163MP0002638_abnormal_pupillary_reflex0.82149326
164MP0003755_abnormal_palate_morphology0.81659804
165MP0005584_abnormal_enzyme/coenzyme_acti0.81084150
166MP0010307_abnormal_tumor_latency0.81018454
167MP0010329_abnormal_lipoprotein_level0.79589895
168MP0003111_abnormal_nucleus_morphology0.79299349
169MP0002928_abnormal_bile_duct0.79192998
170MP0003953_abnormal_hormone_level0.77490689
171MP0002210_abnormal_sex_determination0.76811881
172MP0008872_abnormal_physiological_respon0.74899277
173MP0008875_abnormal_xenobiotic_pharmacok0.74059288
174MP0003698_abnormal_male_reproductive0.73932581
175MP0000358_abnormal_cell_content/0.73838764
176MP0001501_abnormal_sleep_pattern0.72547476
177MP0004270_analgesia0.71267876
178MP0001730_embryonic_growth_arrest0.70450652
179MP0005385_cardiovascular_system_phenoty0.70268532
180MP0001544_abnormal_cardiovascular_syste0.70268532
181MP0003183_abnormal_peptide_metabolism0.67945282
182MP0001873_stomach_inflammation0.66048960
183MP0005670_abnormal_white_adipose0.64097304

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.61003254
2Gout (HP:0001997)4.42398122
3Hypoglycemic coma (HP:0001325)4.22265801
4Pancreatic fibrosis (HP:0100732)4.14499912
5Molar tooth sign on MRI (HP:0002419)4.09957628
6Abnormality of midbrain morphology (HP:0002418)4.09957628
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.96668977
8Abnormality of alanine metabolism (HP:0010916)3.96668977
9Hyperalaninemia (HP:0003348)3.96668977
10Hyperglycinuria (HP:0003108)3.95416929
11True hermaphroditism (HP:0010459)3.93432375
12Myoglobinuria (HP:0002913)3.91998694
13Exercise-induced muscle cramps (HP:0003710)3.91880123
14Exercise-induced myalgia (HP:0003738)3.73851087
15Insulin-resistant diabetes mellitus (HP:0000831)3.66594472
16Muscle fiber inclusion bodies (HP:0100299)3.63770977
17Congenital stationary night blindness (HP:0007642)3.50039998
18Myopathic facies (HP:0002058)3.49289802
19Muscle fiber splitting (HP:0003555)3.47694223
20Hyperinsulinemic hypoglycemia (HP:0000825)3.47287482
21Muscle hypertrophy of the lower extremities (HP:0008968)3.46383765
22Calf muscle hypertrophy (HP:0008981)3.41468751
23Hyperglycemia (HP:0003074)3.40112976
24Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.39742561
25Hyperglycinemia (HP:0002154)3.38480262
26Nephronophthisis (HP:0000090)3.36208144
27Rhabdomyolysis (HP:0003201)3.32354884
28Type II lissencephaly (HP:0007260)3.24168499
29Increased purine levels (HP:0004368)3.23918706
30Hyperuricemia (HP:0002149)3.23918706
31Nemaline bodies (HP:0003798)3.22499348
32Progressive muscle weakness (HP:0003323)3.16172113
33Ketoacidosis (HP:0001993)3.12683650
34Abnormality of the renal cortex (HP:0011035)3.10692490
35Areflexia of lower limbs (HP:0002522)3.05828930
36Abnormality of glycine metabolism (HP:0010895)2.99482550
37Abnormality of serine family amino acid metabolism (HP:0010894)2.99482550
38Abnormality of purine metabolism (HP:0004352)2.93529243
39Abnormality of the renal medulla (HP:0100957)2.91336993
40Hyperventilation (HP:0002883)2.91002035
41Ventricular fibrillation (HP:0001663)2.82411610
42Chronic hepatic failure (HP:0100626)2.75781853
43Medial flaring of the eyebrow (HP:0010747)2.74341724
44Aplasia/Hypoplasia of the tibia (HP:0005772)2.70785745
45Hypoglycemic seizures (HP:0002173)2.69623463
46Lissencephaly (HP:0001339)2.64143607
47Bundle branch block (HP:0011710)2.61914446
48Tubular atrophy (HP:0000092)2.60121234
49Difficulty running (HP:0009046)2.58183611
50Cystic liver disease (HP:0006706)2.55028945
51Cerebellar dysplasia (HP:0007033)2.54345039
52Abnormality of serum amino acid levels (HP:0003112)2.53805350
53Inability to walk (HP:0002540)2.53676179
54Anencephaly (HP:0002323)2.49833161
55Symptomatic seizures (HP:0011145)2.49235687
56Sclerocornea (HP:0000647)2.46609949
57Hyporeflexia of lower limbs (HP:0002600)2.43931198
58Distal arthrogryposis (HP:0005684)2.43797994
59Generalized aminoaciduria (HP:0002909)2.42272593
60Palpitations (HP:0001962)2.40661275
61Pendular nystagmus (HP:0012043)2.40649255
62Hyperkalemia (HP:0002153)2.39109567
63Congenital, generalized hypertrichosis (HP:0004540)2.39057904
64Acute necrotizing encephalopathy (HP:0006965)2.37341753
65Difficulty climbing stairs (HP:0003551)2.36569192
66Rimmed vacuoles (HP:0003805)2.35520314
67Aplasia/Hypoplasia of the tongue (HP:0010295)2.35345122
68Renal cortical cysts (HP:0000803)2.34790623
69Ketosis (HP:0001946)2.34754369
70Dicarboxylic aciduria (HP:0003215)2.33236530
71Abnormality of dicarboxylic acid metabolism (HP:0010995)2.33236530
72Ulnar deviation of the wrist (HP:0003049)2.33031661
73Abnormal drinking behavior (HP:0030082)2.32534302
74Polydipsia (HP:0001959)2.32534302
75Patellar aplasia (HP:0006443)2.31101310
76Gait imbalance (HP:0002141)2.28691722
77Lethargy (HP:0001254)2.27950850
78Keratoconus (HP:0000563)2.25814668
79Increased corneal curvature (HP:0100692)2.25814668
80Muscle stiffness (HP:0003552)2.25230579
81Pelvic girdle muscle weakness (HP:0003749)2.24619398
82Progressive inability to walk (HP:0002505)2.24046189
83Congenital primary aphakia (HP:0007707)2.23952563
84Aplasia/Hypoplasia of the patella (HP:0006498)2.23506745
85Concave nail (HP:0001598)2.21582457
86Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.21567754
87Chorioretinal atrophy (HP:0000533)2.21510702
88Proximal tubulopathy (HP:0000114)2.19897032
89Hepatic necrosis (HP:0002605)2.19719856
90Abolished electroretinogram (ERG) (HP:0000550)2.19059394
91Congenital hepatic fibrosis (HP:0002612)2.18595863
92Optic nerve hypoplasia (HP:0000609)2.18315684
93Postaxial foot polydactyly (HP:0001830)2.18077427
94Attenuation of retinal blood vessels (HP:0007843)2.17638070
95Abnormality of fatty-acid metabolism (HP:0004359)2.17178202
96Nephrogenic diabetes insipidus (HP:0009806)2.16401094
97Bile duct proliferation (HP:0001408)2.16039209
98Abnormal biliary tract physiology (HP:0012439)2.16039209
99Short tibia (HP:0005736)2.15798895
100Right ventricular cardiomyopathy (HP:0011663)2.15509906
101Colon cancer (HP:0003003)2.15030170
102Myotonia (HP:0002486)2.13720308
103Shoulder girdle muscle weakness (HP:0003547)2.12743262
104Increased muscle lipid content (HP:0009058)2.12710546
105Birth length less than 3rd percentile (HP:0003561)2.11357955
106Abnormality of the hip-girdle musculature (HP:0001445)2.11210094
107Abnormality of the musculature of the pelvis (HP:0001469)2.11210094
108Syncope (HP:0001279)2.10952711
109Hyperammonemia (HP:0001987)2.10844103
110Pachygyria (HP:0001302)2.10786998
111Protruding tongue (HP:0010808)2.10712716
112Decreased central vision (HP:0007663)2.09129138
113Abnormality of urine glucose concentration (HP:0011016)2.08979324
114Glycosuria (HP:0003076)2.08979324
115Mitochondrial inheritance (HP:0001427)2.08171803
116Genital tract atresia (HP:0001827)2.08021415
117Abnormality of the pons (HP:0007361)2.06975750
118Sudden death (HP:0001699)2.05295878
119Increased CSF lactate (HP:0002490)2.05190810
120Acanthocytosis (HP:0001927)2.05037816
121Furrowed tongue (HP:0000221)2.05025180
122Abnormality of nucleobase metabolism (HP:0010932)2.04429813
1233-Methylglutaconic aciduria (HP:0003535)2.04199566
124Abnormal biliary tract morphology (HP:0012440)2.02962367
125Metabolic acidosis (HP:0001942)2.02501043
126Acute encephalopathy (HP:0006846)2.02102077
127Acute hepatic failure (HP:0006554)2.01762265
128Vaginal atresia (HP:0000148)2.01632425
129Increased intramyocellular lipid droplets (HP:0012240)2.00512907
130Bilateral microphthalmos (HP:0007633)2.00486169
131Cerebral hypomyelination (HP:0006808)2.00405994
132Cerebral edema (HP:0002181)2.00177318
133Biliary tract neoplasm (HP:0100574)1.98310609
134Abnormal mitochondria in muscle tissue (HP:0008316)1.97539674
135Insulin resistance (HP:0000855)1.97462924
136Progressive macrocephaly (HP:0004481)1.96117292
137Hypoplasia of the pons (HP:0012110)1.95256248
138Large for gestational age (HP:0001520)1.94429026
139Oligomenorrhea (HP:0000876)1.94124726
140Abnormal rod and cone electroretinograms (HP:0008323)1.94068714
141Broad-based gait (HP:0002136)1.93172327
142Occipital encephalocele (HP:0002085)1.92629007
143Ileus (HP:0002595)1.91558937
144Tetraplegia (HP:0002445)1.91267493
145Dandy-Walker malformation (HP:0001305)1.90780562
146Preaxial hand polydactyly (HP:0001177)1.90404464
147CNS demyelination (HP:0007305)1.89757937
148Lactic acidosis (HP:0003128)1.89000673
149Nausea (HP:0002018)1.88451134
150Male pseudohermaphroditism (HP:0000037)1.88235624
151Heart block (HP:0012722)1.85341730
152Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.85017941
153Decreased activity of mitochondrial respiratory chain (HP:0008972)1.85017941
154Polycythemia (HP:0001901)1.83991721
155Partial agenesis of the corpus callosum (HP:0001338)1.83768842
156Methylmalonic acidemia (HP:0002912)1.83378923
157Abnormality of chloride homeostasis (HP:0011422)1.83130607
158Atrioventricular block (HP:0001678)1.82775952
159Rib fusion (HP:0000902)1.82617234
160Limb hypertonia (HP:0002509)1.82340067
161Unsteady gait (HP:0002317)1.82270574
162Postaxial hand polydactyly (HP:0001162)1.82113283
163Lipid accumulation in hepatocytes (HP:0006561)1.81462576
164Genetic anticipation (HP:0003743)1.81396185
165Pheochromocytoma (HP:0002666)1.81328479
166EMG: myopathic abnormalities (HP:0003458)1.80885399
167Abnormal number of erythroid precursors (HP:0012131)1.80827910
168Aplasia/Hypoplasia of the uvula (HP:0010293)1.78798272
169Gaze-evoked nystagmus (HP:0000640)1.78737028
170Testicular atrophy (HP:0000029)1.78139533
171Poor coordination (HP:0002370)1.77369088
172Distal lower limb muscle weakness (HP:0009053)1.77236413
173Athetosis (HP:0002305)1.77234748
174EMG: neuropathic changes (HP:0003445)1.76834668
175Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76766698
176Visual hallucinations (HP:0002367)1.76357866
177Retinal dysplasia (HP:0007973)1.76291399
178Anophthalmia (HP:0000528)1.75985705
179Ectopic kidney (HP:0000086)1.75694247
180Ventricular tachycardia (HP:0004756)1.75533537
181Hypokalemia (HP:0002900)1.75232278
182Hypoalphalipoproteinemia (HP:0003233)1.75126348
183Severe muscular hypotonia (HP:0006829)1.74007967
184Hypoplasia of the fovea (HP:0007750)1.70622620
185Aplasia/Hypoplasia of the fovea (HP:0008060)1.70622620
186Small hand (HP:0200055)1.70521764
187Clumsiness (HP:0002312)1.69795836
188Polyuria (HP:0000103)1.68021392
189Abnormality of the labia minora (HP:0012880)1.67602470
190Decreased circulating renin level (HP:0003351)1.67464616
191Optic disc pallor (HP:0000543)1.66484665
192Decreased electroretinogram (ERG) amplitude (HP:0000654)1.65761157
193Methylmalonic aciduria (HP:0012120)1.65294569

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B3.79309326
2AKT33.40877276
3PDK33.18013711
4PDK43.18013711
5BCKDK3.17479269
6ADRBK22.95992826
7NME12.82158648
8TLK12.79589938
9INSRR2.77481456
10MAP4K22.77287214
11IRAK32.77057895
12OBSCN2.76326657
13NEK12.71532217
14EPHA22.70925519
15NUAK12.51767972
16EIF2AK12.40005369
17FRK2.30865452
18PINK12.25745492
19LMTK22.23565281
20PDK22.19432003
21BRSK22.11326264
22GRK12.06754744
23CASK2.04456771
24WEE11.81543007
25PHKG21.74890626
26PHKG11.74890626
27ACVR1B1.70550374
28TNIK1.70413483
29MAP3K91.66212282
30MAPK131.65784073
31SCYL21.65275633
32WNK41.63791999
33EIF2AK31.55899872
34TAOK31.52630426
35ZAK1.45683692
36MKNK21.45482420
37MAPKAPK31.41383372
38BUB11.38154543
39PNCK1.36371892
40MAP3K51.36147514
41DYRK21.35676186
42TIE11.31408850
43TTK1.31177467
44ADRBK11.23887525
45TTN1.23258985
46VRK11.22802849
47ARAF1.21465966
48TGFBR11.21388119
49STK38L1.18481638
50PRKAA11.16876907
51CDC71.16405539
52BCR1.14953766
53BRAF1.10215479
54PLK41.06245421
55MARK11.03846968
56TRIM281.03714650
57MAP3K31.03007640
58MAP2K71.02821125
59TXK1.00200871
60KSR20.99246132
61ERBB30.98958113
62MKNK10.97587580
63CAMKK20.96344485
64MAP2K40.95767900
65WNK30.95263802
66MAP3K20.93683066
67DAPK20.91841344
68NEK90.90680501
69PAK30.90266792
70STK380.89869558
71STK240.88447844
72CSNK1G20.87799324
73CSNK1G10.87626098
74PLK20.86697319
75CHEK20.84371433
76STK160.84008475
77PIK3CA0.83258525
78ERBB40.82001963
79JAK30.80290813
80MST40.79649831
81SRPK10.79554064
82RPS6KA50.76340241
83TSSK60.76246422
84MAP3K140.76020860
85CSNK1G30.74894422
86PRKCE0.73367026
87PKN10.73298817
88FLT30.72382897
89MARK30.71863792
90TAOK10.71444492
91MAPK150.71225734
92JAK20.71042787
93NME20.70507729
94CSNK1A1L0.69091266
95PRKCG0.69008960
96NLK0.66441298
97VRK20.65673978
98RPS6KB20.64755678
99PIK3CG0.64194163
100DYRK30.63124266
101MAP3K110.62303653
102PBK0.61683773
103MAP2K30.61171955
104PRKAA20.60069797
105TEC0.59857168
106EPHB20.59407819
107NTRK20.58769443
108EPHA30.57961316
109MUSK0.57898491
110MAP3K40.55874222
111NEK20.55750745
112RAF10.55419188
113STK30.54774483
114PLK10.54640636
115BRSK10.53992505
116CAMK2A0.53573302
117MAP3K130.52493927
118FER0.51916074
119MAP3K10.51822421
120PTK2B0.49839444
121PDK10.48563533
122EIF2AK20.47979574
123PDPK10.47532660
124IRAK10.47508409
125PRKCI0.47326298
126MAPKAPK50.46679254
127MAPK110.46152873
128CAMK10.45975381
129ATR0.45518489
130BMPR20.44903169
131PLK30.44585540
132STK390.44122265
133PIM10.43597230
134MAP3K70.43453560
135MAP3K80.42908735
136ALK0.42306605
137CCNB10.41879507
138MST1R0.41733896
139LATS10.41227880
140CAMK2G0.41146219
141GRK50.39728531
142MAP2K10.39504231
143PRKACA0.39473363
144CSNK1E0.39251083
145PRKCQ0.39178172
146STK110.39144315
147ABL20.39087168
148IKBKB0.38349151
149WNK10.38036721
150OXSR10.36541745
151CDK40.36267028
152NTRK30.36070046
153TAF10.35471774
154CSNK1A10.35438467
155CDK30.34822311
156PRKACG0.34783919
157ERBB20.34669875
158MAP2K20.34364134
159CAMK40.33478375
160HIPK20.32634679
161RPS6KA40.32045551
162ATM0.31560323
163RIPK40.31141348
164PRKD30.30663247
165TYK20.29699012
166PRKG20.29195154

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.69505811
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.62164430
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.22252523
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.93083740
5Phototransduction_Homo sapiens_hsa047442.63709595
6Homologous recombination_Homo sapiens_hsa034402.51815996
7Folate biosynthesis_Homo sapiens_hsa007902.45461398
8Vitamin B6 metabolism_Homo sapiens_hsa007502.43573974
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40855331
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35571475
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.29767165
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.26690956
13Linoleic acid metabolism_Homo sapiens_hsa005912.25477056
14Propanoate metabolism_Homo sapiens_hsa006402.24110385
15Basal transcription factors_Homo sapiens_hsa030222.18616437
16Carbon metabolism_Homo sapiens_hsa012002.07692117
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.03561852
18Regulation of autophagy_Homo sapiens_hsa041402.00993221
19Fanconi anemia pathway_Homo sapiens_hsa034601.99162016
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.93982430
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.90345727
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.90342848
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.83876874
24Fat digestion and absorption_Homo sapiens_hsa049751.81034560
25RNA degradation_Homo sapiens_hsa030181.66593476
26Starch and sucrose metabolism_Homo sapiens_hsa005001.65802999
27Fatty acid degradation_Homo sapiens_hsa000711.63168768
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61523698
29RNA polymerase_Homo sapiens_hsa030201.56027304
30Fructose and mannose metabolism_Homo sapiens_hsa000511.51222277
31Sulfur metabolism_Homo sapiens_hsa009201.50015098
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49706388
33Biosynthesis of amino acids_Homo sapiens_hsa012301.47614246
34Pyruvate metabolism_Homo sapiens_hsa006201.44498778
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43542934
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.42858505
37Circadian rhythm_Homo sapiens_hsa047101.42381520
38Nicotine addiction_Homo sapiens_hsa050331.42138410
39Protein export_Homo sapiens_hsa030601.41968591
40Type I diabetes mellitus_Homo sapiens_hsa049401.41671626
41Butanoate metabolism_Homo sapiens_hsa006501.41273504
42Galactose metabolism_Homo sapiens_hsa000521.40553492
43Pancreatic secretion_Homo sapiens_hsa049721.40027966
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39310997
45Oxidative phosphorylation_Homo sapiens_hsa001901.38629728
46Ether lipid metabolism_Homo sapiens_hsa005651.37881038
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.34642837
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34565688
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34306744
50Pentose phosphate pathway_Homo sapiens_hsa000301.31297088
51Parkinsons disease_Homo sapiens_hsa050121.30684397
52Ribosome_Homo sapiens_hsa030101.21848228
53Nucleotide excision repair_Homo sapiens_hsa034201.20039993
54Selenocompound metabolism_Homo sapiens_hsa004501.19853855
55Arginine biosynthesis_Homo sapiens_hsa002201.17747673
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17530871
57Cardiac muscle contraction_Homo sapiens_hsa042601.17292853
58Olfactory transduction_Homo sapiens_hsa047401.15864563
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15155449
60Nitrogen metabolism_Homo sapiens_hsa009101.14957886
61Vitamin digestion and absorption_Homo sapiens_hsa049771.12250960
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08387749
63Primary bile acid biosynthesis_Homo sapiens_hsa001201.06438255
64Tryptophan metabolism_Homo sapiens_hsa003801.03638358
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03389395
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01151241
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00778806
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.99887886
69Steroid biosynthesis_Homo sapiens_hsa001000.98612248
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97289914
71Insulin resistance_Homo sapiens_hsa049310.96405021
72Proteasome_Homo sapiens_hsa030500.93117003
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.92772320
74Insulin secretion_Homo sapiens_hsa049110.92771278
75Taste transduction_Homo sapiens_hsa047420.91322169
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91139381
77Morphine addiction_Homo sapiens_hsa050320.90799365
78Arginine and proline metabolism_Homo sapiens_hsa003300.90581581
79Mismatch repair_Homo sapiens_hsa034300.90545399
80Fatty acid metabolism_Homo sapiens_hsa012120.89230212
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88944841
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88515705
83beta-Alanine metabolism_Homo sapiens_hsa004100.87987566
84Glycerolipid metabolism_Homo sapiens_hsa005610.86121787
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.86119367
86Non-homologous end-joining_Homo sapiens_hsa034500.85438593
87Serotonergic synapse_Homo sapiens_hsa047260.84589856
88Insulin signaling pathway_Homo sapiens_hsa049100.84263605
89Type II diabetes mellitus_Homo sapiens_hsa049300.84241657
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.84037932
91Alzheimers disease_Homo sapiens_hsa050100.83533383
92Huntingtons disease_Homo sapiens_hsa050160.80892756
93Peroxisome_Homo sapiens_hsa041460.80176476
94Chemical carcinogenesis_Homo sapiens_hsa052040.79979507
95Purine metabolism_Homo sapiens_hsa002300.79959925
96Arachidonic acid metabolism_Homo sapiens_hsa005900.76925569
97Retinol metabolism_Homo sapiens_hsa008300.76746823
98Pyrimidine metabolism_Homo sapiens_hsa002400.76676271
99Glucagon signaling pathway_Homo sapiens_hsa049220.76431142
100RNA transport_Homo sapiens_hsa030130.75099589
101ABC transporters_Homo sapiens_hsa020100.74409525
102Basal cell carcinoma_Homo sapiens_hsa052170.73213585
103Circadian entrainment_Homo sapiens_hsa047130.72069397
104Mineral absorption_Homo sapiens_hsa049780.71679913
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71516100
106Hedgehog signaling pathway_Homo sapiens_hsa043400.70118624
107AMPK signaling pathway_Homo sapiens_hsa041520.69616130
108Renin-angiotensin system_Homo sapiens_hsa046140.65548085
109Glutamatergic synapse_Homo sapiens_hsa047240.64743284
110mTOR signaling pathway_Homo sapiens_hsa041500.64352008
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60542791
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60275964
113Metabolic pathways_Homo sapiens_hsa011000.59680365
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.59262079
115Inositol phosphate metabolism_Homo sapiens_hsa005620.58103629
116Calcium signaling pathway_Homo sapiens_hsa040200.57156301
117GABAergic synapse_Homo sapiens_hsa047270.57058764
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56593207
119Legionellosis_Homo sapiens_hsa051340.56450903
120Hippo signaling pathway_Homo sapiens_hsa043900.55110707
121TGF-beta signaling pathway_Homo sapiens_hsa043500.53395204
122Phenylalanine metabolism_Homo sapiens_hsa003600.52875918
123Vibrio cholerae infection_Homo sapiens_hsa051100.52337281
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51715654
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51542192
126Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51540171
127p53 signaling pathway_Homo sapiens_hsa041150.51310828
128Ovarian steroidogenesis_Homo sapiens_hsa049130.50765928
129Protein digestion and absorption_Homo sapiens_hsa049740.47802745
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47523274
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47150613
132Caffeine metabolism_Homo sapiens_hsa002320.46847481
133Alcoholism_Homo sapiens_hsa050340.46505537
134Bile secretion_Homo sapiens_hsa049760.45825680
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44317885
136Systemic lupus erythematosus_Homo sapiens_hsa053220.43031585
137Drug metabolism - other enzymes_Homo sapiens_hsa009830.42931576
138PPAR signaling pathway_Homo sapiens_hsa033200.42504008
139Long-term depression_Homo sapiens_hsa047300.42264861
140Collecting duct acid secretion_Homo sapiens_hsa049660.41153736
141Synaptic vesicle cycle_Homo sapiens_hsa047210.40379442
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39800161
143FoxO signaling pathway_Homo sapiens_hsa040680.38192447
144Allograft rejection_Homo sapiens_hsa053300.38003385
145Fatty acid elongation_Homo sapiens_hsa000620.37589452
146Dopaminergic synapse_Homo sapiens_hsa047280.36891919
147Sulfur relay system_Homo sapiens_hsa041220.36829452
148Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35573282
149Fatty acid biosynthesis_Homo sapiens_hsa000610.35563844
150Base excision repair_Homo sapiens_hsa034100.35452469
151Prolactin signaling pathway_Homo sapiens_hsa049170.32309904
152Glutathione metabolism_Homo sapiens_hsa004800.32188618
153Vascular smooth muscle contraction_Homo sapiens_hsa042700.32176982
154Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31665467
155One carbon pool by folate_Homo sapiens_hsa006700.30947961
156Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30860465

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