UBXN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)4.85476030
2formation of translation preinitiation complex (GO:0001731)4.77977107
3nucleobase biosynthetic process (GO:0046112)4.69495602
4DNA deamination (GO:0045006)4.56702770
5ribosome assembly (GO:0042255)4.52437043
6maturation of SSU-rRNA (GO:0030490)4.48430479
7folic acid metabolic process (GO:0046655)4.41574053
8macromolecular complex disassembly (GO:0032984)4.23144508
9negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.13248732
10ribosome biogenesis (GO:0042254)4.09612456
11proteasome assembly (GO:0043248)4.07634838
12ribosomal large subunit biogenesis (GO:0042273)3.99868008
13ribosomal small subunit assembly (GO:0000028)3.93171882
14ribonucleoprotein complex biogenesis (GO:0022613)3.90879727
15viral transcription (GO:0019083)3.88041507
16protein targeting to membrane (GO:0006612)3.86683772
17translational termination (GO:0006415)3.82938199
18translational initiation (GO:0006413)3.78529754
19ribosomal small subunit biogenesis (GO:0042274)3.75725956
20mitotic metaphase plate congression (GO:0007080)3.69804145
21glycine metabolic process (GO:0006544)3.63385926
22DNA strand elongation involved in DNA replication (GO:0006271)3.60976142
23NIK/NF-kappaB signaling (GO:0038061)3.58141277
24translational elongation (GO:0006414)3.57496366
25DNA replication checkpoint (GO:0000076)3.55746119
26pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.53651042
27purine deoxyribonucleotide catabolic process (GO:0009155)3.51358528
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.48335112
29DNA replication initiation (GO:0006270)3.46609763
30deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.45309933
31positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.43544008
32anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.43432382
33rRNA modification (GO:0000154)3.42529322
34DNA strand elongation (GO:0022616)3.41607060
35rRNA processing (GO:0006364)3.40921042
36regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.39013740
37nuclear-transcribed mRNA catabolic process (GO:0000956)3.37695818
38folic acid-containing compound biosynthetic process (GO:0009396)3.33234248
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.33103892
40deoxyribonucleotide catabolic process (GO:0009264)3.31751566
41rRNA metabolic process (GO:0016072)3.30763724
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.24727460
43mRNA catabolic process (GO:0006402)3.24496762
44folic acid transport (GO:0015884)3.23246875
45spliceosomal snRNP assembly (GO:0000387)3.21848620
46telomere maintenance via semi-conservative replication (GO:0032201)3.21162848
47negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.19050526
48negative regulation of ligase activity (GO:0051352)3.19050526
49SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.16939899
50positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.15467506
51protein localization to kinetochore (GO:0034501)3.11811225
52deoxyribose phosphate catabolic process (GO:0046386)3.08851295
53transcription elongation from RNA polymerase III promoter (GO:0006385)3.08825002
54termination of RNA polymerase III transcription (GO:0006386)3.08825002
55protein targeting to ER (GO:0045047)3.07725848
56regulation of translation in response to stress (GO:0043555)3.06546725
57translation (GO:0006412)3.06176829
58cotranslational protein targeting to membrane (GO:0006613)3.05728785
59DNA replication-dependent nucleosome assembly (GO:0006335)3.05171278
60DNA replication-dependent nucleosome organization (GO:0034723)3.05171278
61L-methionine biosynthetic process (GO:0071265)3.04884963
62amino acid salvage (GO:0043102)3.04884963
63L-methionine salvage (GO:0071267)3.04884963
64regulation of spindle organization (GO:0090224)3.04789862
65pyrimidine nucleotide catabolic process (GO:0006244)3.03313562
66pentose metabolic process (GO:0019321)3.02704287
67positive regulation of gamma-delta T cell activation (GO:0046645)3.01852280
68nucleotide salvage (GO:0043173)3.01661378
69mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.00657321
70RNA catabolic process (GO:0006401)2.99921390
71positive regulation of ligase activity (GO:0051351)2.99029082
72mitotic nuclear envelope disassembly (GO:0007077)2.98612284
73protein maturation by protein folding (GO:0022417)2.98526477
74chaperone-mediated protein transport (GO:0072321)2.98222413
75viral life cycle (GO:0019058)2.98128744
76pyrimidine-containing compound salvage (GO:0008655)2.97250073
77pyrimidine nucleoside salvage (GO:0043097)2.97250073
78energy coupled proton transport, down electrochemical gradient (GO:0015985)2.97121092
79ATP synthesis coupled proton transport (GO:0015986)2.97121092
80viral protein processing (GO:0019082)2.97055721
81base-excision repair, AP site formation (GO:0006285)2.96799851
82immunoglobulin mediated immune response (GO:0016064)2.95950785
83IMP biosynthetic process (GO:0006188)2.95832132
84regulation of cellular amino acid metabolic process (GO:0006521)2.95691121
85cellular protein complex disassembly (GO:0043624)2.95288778
86signal transduction involved in DNA damage checkpoint (GO:0072422)2.95134480
87signal transduction involved in DNA integrity checkpoint (GO:0072401)2.95134480
88DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.94796257
89protein localization to endoplasmic reticulum (GO:0070972)2.94400644
90protein targeting to mitochondrion (GO:0006626)2.93105375
91serine family amino acid biosynthetic process (GO:0009070)2.92998821
92positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.92753134
93modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.92712545
94modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.92712545
95positive regulation by organism of defense response of other organism involved in symbiotic interact2.92712545
96modulation by symbiont of host immune response (GO:0052553)2.92712545
97positive regulation by symbiont of host defense response (GO:0052509)2.92712545
98modulation by symbiont of host defense response (GO:0052031)2.92712545
99signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.91587240
100signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.91587240
101signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.91587240
102establishment of protein localization to endoplasmic reticulum (GO:0072599)2.90905093
103DNA unwinding involved in DNA replication (GO:0006268)2.90257623
104signal transduction involved in cell cycle checkpoint (GO:0072395)2.89841870
105cellular component biogenesis (GO:0044085)2.89727895
106intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.89047367
107signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.89047367
108L-serine metabolic process (GO:0006563)2.88986015
109regulation of translational termination (GO:0006449)2.84878888
110metaphase plate congression (GO:0051310)2.84538081
111establishment of protein localization to membrane (GO:0090150)2.83835589
112telomere maintenance via recombination (GO:0000722)2.80454837
113pseudouridine synthesis (GO:0001522)2.80427307
114regulation of ubiquitin-protein transferase activity (GO:0051438)2.79927772
115transcription from RNA polymerase I promoter (GO:0006360)2.79443641
116negative regulation of translational initiation (GO:0045947)2.79243439
117negative regulation of DNA-templated transcription, elongation (GO:0032785)2.79025554
118activation of MAPKKK activity (GO:0000185)2.75812806
119establishment of protein localization to mitochondrion (GO:0072655)2.75768577
120pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.75266216
121G1/S transition of mitotic cell cycle (GO:0000082)2.74391004
122cell cycle G1/S phase transition (GO:0044843)2.74391004
123metallo-sulfur cluster assembly (GO:0031163)2.73353347
124iron-sulfur cluster assembly (GO:0016226)2.73353347
125protein localization to chromosome, centromeric region (GO:0071459)2.73288623
126nuclear envelope disassembly (GO:0051081)2.73114753
127membrane disassembly (GO:0030397)2.73114753
128methionine biosynthetic process (GO:0009086)2.72769453
129serine family amino acid metabolic process (GO:0009069)2.71870109
130Arp2/3 complex-mediated actin nucleation (GO:0034314)2.71342536
131respiratory electron transport chain (GO:0022904)2.71016921
132termination of RNA polymerase I transcription (GO:0006363)2.69830241
133blastocyst development (GO:0001824)2.69531841
134protein complex disassembly (GO:0043241)2.69370734
135serine family amino acid catabolic process (GO:0009071)2.69114457
136regulation of superoxide anion generation (GO:0032928)2.68785519
137regulation of ligase activity (GO:0051340)2.67647022
138transcription-coupled nucleotide-excision repair (GO:0006283)2.66792188
139regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.66554174
140negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.66414151
141IMP metabolic process (GO:0046040)2.66165497
142folic acid-containing compound metabolic process (GO:0006760)2.65894884
143antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.65424879
144sulfur amino acid biosynthetic process (GO:0000097)2.63943820
145L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.63657654
146negative regulation of cell killing (GO:0031342)2.63191239
147negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.63191239
148positive thymic T cell selection (GO:0045059)2.62739688
149positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.62189808
150protein targeting (GO:0006605)2.61523205
151electron transport chain (GO:0022900)2.61129487
152modulation by virus of host process (GO:0019054)2.60892080
153pentose-phosphate shunt (GO:0006098)2.58730604
154establishment of protein localization to mitochondrial membrane (GO:0090151)2.56544719
155oxidative phosphorylation (GO:0006119)2.55609192
156positive regulation of B cell differentiation (GO:0045579)2.53488681
157mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.52097897
158negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.51382413
1592-deoxyribonucleotide metabolic process (GO:0009394)2.51195114
160RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.49725529
161tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.49725529
162protein localization to mitochondrion (GO:0070585)2.48311747
1633-UTR-mediated mRNA stabilization (GO:0070935)2.46171129
164negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.45593845
165positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.43792128
166establishment of mitochondrion localization (GO:0051654)2.43460285
167response to peptidoglycan (GO:0032494)2.43087005
168positive regulation of T cell apoptotic process (GO:0070234)2.42650240
169mitochondrion transport along microtubule (GO:0047497)2.41878514
170establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.41878514
171deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.41146318
172neutrophil activation involved in immune response (GO:0002283)2.39600431
173protein insertion into membrane (GO:0051205)2.38439724
174antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.38181781
175spliceosomal tri-snRNP complex assembly (GO:0000244)2.37139259
176negative regulation of myeloid cell apoptotic process (GO:0033033)2.37022779
177antigen processing and presentation of endogenous antigen (GO:0019883)2.35930535
178heme biosynthetic process (GO:0006783)2.34818407

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.89445697
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.84032202
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.66392019
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.89980957
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.84866995
6* ETS1_20019798_ChIP-Seq_JURKAT_Human2.81802674
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81342194
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.71449961
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69395148
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.68515409
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.67860256
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.64740314
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.63146070
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53573123
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.40174857
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26891652
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.21559836
18XRN2_22483619_ChIP-Seq_HELA_Human2.16657071
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.15278427
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10615434
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05484264
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98036115
23E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96014957
24VDR_23849224_ChIP-Seq_CD4+_Human1.95642375
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.87281063
26GABP_19822575_ChIP-Seq_HepG2_Human1.82252735
27DCP1A_22483619_ChIP-Seq_HELA_Human1.81578907
28LXR_22292898_ChIP-Seq_THP-1_Human1.80510490
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77106514
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76921608
31AR_21909140_ChIP-Seq_LNCAP_Human1.74945967
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.73095844
33STAT3_1855785_ChIP-Seq_MESCs_Mouse1.72008319
34ZNF263_19887448_ChIP-Seq_K562_Human1.67082016
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66547068
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.66360907
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.63440041
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62849305
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61618184
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61178860
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61029761
42* FOXP3_21729870_ChIP-Seq_TREG_Human1.59662097
43ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.58370210
44* MAF_26560356_Chip-Seq_TH2_Human1.57601422
45* TET1_21451524_ChIP-Seq_MESCs_Mouse1.54247559
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.53409822
47SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.52011842
48UTX_26944678_Chip-Seq_JUKART_Human1.50589376
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49426941
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48122196
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47705857
52TTF2_22483619_ChIP-Seq_HELA_Human1.47012921
53ELF1_20517297_ChIP-Seq_JURKAT_Human1.46535729
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45877003
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.44690801
56MAF_26560356_Chip-Seq_TH1_Human1.44491860
57KDM5A_27292631_Chip-Seq_BREAST_Human1.44170762
58* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43717900
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.43629933
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40936577
61* BCL6_27268052_Chip-Seq_Bcells_Human1.37768136
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37709281
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37221843
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.36363689
65* P68_20966046_ChIP-Seq_HELA_Human1.36077835
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35829122
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34103772
68MYC_22102868_ChIP-Seq_BL_Human1.33568940
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33439726
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33398553
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32253374
72VDR_24763502_ChIP-Seq_THP-1_Human1.32076180
73CTCF_18555785_ChIP-Seq_MESCs_Mouse1.31935100
74SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.31858915
75SA1_27219007_Chip-Seq_ERYTHROID_Human1.31598653
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.30734710
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29799435
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.29745128
79* SPI1_23547873_ChIP-Seq_NB4_Human1.29717111
80KDM2B_26808549_Chip-Seq_DND41_Human1.28604648
81CIITA_25753668_ChIP-Seq_RAJI_Human1.26096488
82* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26040729
83EGR1_19374776_ChIP-ChIP_THP-1_Human1.25769924
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24860996
85* BCOR_27268052_Chip-Seq_Bcells_Human1.24190651
86CTCF_26484167_Chip-Seq_Bcells_Mouse1.23947375
87* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23234475
88KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22791516
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21317619
90E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21122219
91* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18591207
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18504339
93STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18501132
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17846947
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16883181
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16778514
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16450128
98TP63_17297297_ChIP-ChIP_HaCaT_Human1.16390965
99PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16239458
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15839423
101FOXP1_21924763_ChIP-Seq_HESCs_Human1.15751556
102* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15620676
103IRF8_22096565_ChIP-ChIP_GC-B_Human1.15491725
104YY1_22570637_ChIP-Seq_MALME-3M_Human1.15030392
105POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13822139
106* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13753415
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12786548
108TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12175723
109* TFEB_21752829_ChIP-Seq_HELA_Human1.11873926
110* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10148325
111* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10126883
112OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10027819
113* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09569202
114ELK1_19687146_ChIP-ChIP_HELA_Human1.09416054
115SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08510393
116NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.08206042
117YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07376073
118HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06441216
119RUNX1_22412390_ChIP-Seq_EML_Mouse1.05877992
120SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05745393
121KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04807796
122KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04807796
123KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04807796
124PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04762170
125NCOR1_26117541_ChIP-Seq_K562_Human1.04234420
126ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01935493
127KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01676850
128TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01369663
129* CTCF_21964334_Chip-Seq_Bcells_Human1.01033853
130SA1_27219007_Chip-Seq_Bcells_Human1.00922459
131RACK7_27058665_Chip-Seq_MCF-7_Human1.00802176
132PHF8_20622854_ChIP-Seq_HELA_Human1.00464026
133* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00236622
134GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99914043
135TCF7_22412390_ChIP-Seq_EML_Mouse0.99403806
136ELK1_22589737_ChIP-Seq_MCF10A_Human0.99387847
137VDR_21846776_ChIP-Seq_THP-1_Human0.98903793
138RXR_22158963_ChIP-Seq_LIVER_Mouse0.98520177
139TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98194181
140HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95602524
141SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95171286
142* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94007103
143SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93365384
144E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92630637
145CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92144180
146HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91875404
147NANOG_21062744_ChIP-ChIP_HESCs_Human0.90060863

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.87999539
2MP0004957_abnormal_blastocyst_morpholog3.73917934
3MP0003111_abnormal_nucleus_morphology3.70060710
4MP0009379_abnormal_foot_pigmentation3.42455749
5MP0003806_abnormal_nucleotide_metabolis3.42428043
6MP0003303_peritoneal_inflammation3.35053583
7MP0009840_abnormal_foam_cell3.29925287
8MP0003077_abnormal_cell_cycle3.00888831
9MP0003436_decreased_susceptibility_to2.87089338
10MP0010094_abnormal_chromosome_stability2.85839635
11MP0005671_abnormal_response_to2.59363857
12MP0001835_abnormal_antigen_presentation2.35062170
13MP0005000_abnormal_immune_tolerance2.32182819
14MP0003718_maternal_effect2.31690577
15MP0002148_abnormal_hypersensitivity_rea2.27967749
16MP0009785_altered_susceptibility_to2.27745704
17MP0005025_abnormal_response_to2.22262181
18MP0001800_abnormal_humoral_immune2.20587012
19MP0005387_immune_system_phenotype2.18060566
20MP0001790_abnormal_immune_system2.18060566
21MP0001730_embryonic_growth_arrest2.14506096
22MP0002723_abnormal_immune_serum2.07641035
23MP0008058_abnormal_DNA_repair2.03001049
24MP0008932_abnormal_embryonic_tissue2.02890955
25MP0002420_abnormal_adaptive_immunity2.00750361
26MP0001819_abnormal_immune_cell1.98791098
27MP0003186_abnormal_redox_activity1.97950252
28MP0002452_abnormal_antigen_presenting1.97192287
29MP0004510_myositis1.97009155
30MP0008057_abnormal_DNA_replication1.93327356
31MP0000685_abnormal_immune_system1.90032890
32MP0002822_catalepsy1.88877300
33MP0010352_gastrointestinal_tract_polyps1.87249968
34MP0002419_abnormal_innate_immunity1.85628323
35MP0008007_abnormal_cellular_replicative1.85265153
36MP0003786_premature_aging1.76968915
37MP0002398_abnormal_bone_marrow1.71978691
38MP0008260_abnormal_autophagy1.65434163
39MP0000350_abnormal_cell_proliferation1.65240505
40MP0000716_abnormal_immune_system1.64940042
41MP0003763_abnormal_thymus_physiology1.63527857
42MP0002139_abnormal_hepatobiliary_system1.58384307
43MP0005380_embryogenesis_phenotype1.57103652
44MP0001672_abnormal_embryogenesis/_devel1.57103652
45MP0003705_abnormal_hypodermis_morpholog1.56548017
46MP0002396_abnormal_hematopoietic_system1.55114191
47MP0003123_paternal_imprinting1.52137342
48MP0005464_abnormal_platelet_physiology1.50945409
49MP0002429_abnormal_blood_cell1.48878429
50MP0010307_abnormal_tumor_latency1.48563773
51MP0009333_abnormal_splenocyte_physiolog1.48499218
52MP0000343_altered_response_to1.46243895
53MP0001697_abnormal_embryo_size1.45641580
54MP0002080_prenatal_lethality1.44445358
55MP0003984_embryonic_growth_retardation1.43954687
56MP0002163_abnormal_gland_morphology1.43202035
57MP0003221_abnormal_cardiomyocyte_apopto1.42762219
58MP0002088_abnormal_embryonic_growth/wei1.41789882
59MP0002138_abnormal_hepatobiliary_system1.39922219
60MP0006082_CNS_inflammation1.36652760
61MP0003567_abnormal_fetal_cardiomyocyte1.35662190
62MP0000372_irregular_coat_pigmentation1.34773227
63MP0005075_abnormal_melanosome_morpholog1.34403706
64MP0005360_urolithiasis1.33813660
65MP0000703_abnormal_thymus_morphology1.33742380
66MP0006036_abnormal_mitochondrial_physio1.32503820
67MP0001545_abnormal_hematopoietic_system1.30996263
68MP0005397_hematopoietic_system_phenotyp1.30996263
69MP0005332_abnormal_amino_acid1.30800417
70MP0001845_abnormal_inflammatory_respons1.30608154
71MP0003724_increased_susceptibility_to1.29782953
72MP0005451_abnormal_body_composition1.27434371
73MP0000490_abnormal_crypts_of1.26588278
74MP0000358_abnormal_cell_content/1.25753551
75MP0005085_abnormal_gallbladder_physiolo1.25455815
76MP0000750_abnormal_muscle_regeneration1.24979450
77MP0002086_abnormal_extraembryonic_tissu1.24261332
78MP0005365_abnormal_bile_salt1.22413636
79MP0010155_abnormal_intestine_physiology1.22076751
80MP0002405_respiratory_system_inflammati1.20973117
81MP0003191_abnormal_cellular_cholesterol1.19940935
82MP0005058_abnormal_lysosome_morphology1.19551283
83MP0000313_abnormal_cell_death1.17514248
84MP0002019_abnormal_tumor_incidence1.17058639
85MP0002085_abnormal_embryonic_tissue1.16041245
86MP0003172_abnormal_lysosome_physiology1.14270521
87MP0008469_abnormal_protein_level1.11949517
88MP0002277_abnormal_respiratory_mucosa1.10013848
89MP0005319_abnormal_enzyme/_coenzyme1.09207679
90MP0009764_decreased_sensitivity_to1.08222730
91MP0004019_abnormal_vitamin_homeostasis1.07662902
92MP0003656_abnormal_erythrocyte_physiolo1.06993591
93MP0002084_abnormal_developmental_patter1.06649812
94MP0006035_abnormal_mitochondrial_morpho1.06226741
95MP0004197_abnormal_fetal_growth/weight/1.05366530
96MP0000604_amyloidosis1.01992545
97MP0004381_abnormal_hair_follicle1.01516340
98MP0004858_abnormal_nervous_system0.98895528
99MP0000609_abnormal_liver_physiology0.98020403
100MP0005023_abnormal_wound_healing0.96216689
101MP0002132_abnormal_respiratory_system0.95951271
102MP0008995_early_reproductive_senescence0.95049772
103MP0000598_abnormal_liver_morphology0.94662031
104MP0000678_abnormal_parathyroid_gland0.94605728
105MP0009278_abnormal_bone_marrow0.94185265
106MP0002269_muscular_atrophy0.93630980
107MP0005395_other_phenotype0.92172529
108MP0001727_abnormal_embryo_implantation0.89899037
109MP0005670_abnormal_white_adipose0.89005442
110MP0002877_abnormal_melanocyte_morpholog0.88327192
111MP0004084_abnormal_cardiac_muscle0.88081573
112MP0002653_abnormal_ependyma_morphology0.87030195
113MP0003075_altered_response_to0.86887206
114MP0001533_abnormal_skeleton_physiology0.86828564
115MP0004947_skin_inflammation0.86799144
116MP0003866_abnormal_defecation0.86492329
117MP0010030_abnormal_orbit_morphology0.86147849
118MP0003878_abnormal_ear_physiology0.86122298
119MP0005377_hearing/vestibular/ear_phenot0.86122298
120MP0001661_extended_life_span0.86034818
121MP0003329_amyloid_beta_deposits0.85871446
122MP0009053_abnormal_anal_canal0.84841895
123MP0003315_abnormal_perineum_morphology0.84762455
124MP0009765_abnormal_xenobiotic_induced0.84694732
125MP0009672_abnormal_birth_weight0.84451459
126MP0009643_abnormal_urine_homeostasis0.84052361
127MP0001764_abnormal_homeostasis0.83005841
128MP0003566_abnormal_cell_adhesion0.81838257
129MP0010329_abnormal_lipoprotein_level0.81709924
130MP0001756_abnormal_urination0.78423276
131MP0001849_ear_inflammation0.77692619
132MP0001145_abnormal_male_reproductive0.76865228
133MP0003646_muscle_fatigue0.76330932
134MP0001905_abnormal_dopamine_level0.76254444
135MP0008875_abnormal_xenobiotic_pharmacok0.76008288
136MP0004808_abnormal_hematopoietic_stem0.75793336
137MP0001293_anophthalmia0.75423490
138MP0000747_muscle_weakness0.74865978
139MP0000858_altered_metastatic_potential0.74241562
140MP0000537_abnormal_urethra_morphology0.74107435
141MP0002210_abnormal_sex_determination0.74008881
142MP0005330_cardiomyopathy0.73661044
143MP0002722_abnormal_immune_system0.73218026
144MP0005076_abnormal_cell_differentiation0.72741577
145MP0005501_abnormal_skin_physiology0.71424322
146MP0001663_abnormal_digestive_system0.71242474
147MP0001986_abnormal_taste_sensitivity0.71021761
148MP0005384_cellular_phenotype0.70997760
149MP0000689_abnormal_spleen_morphology0.70538861
150MP0003183_abnormal_peptide_metabolism0.69839768
151MP0002796_impaired_skin_barrier0.67974667
152MP0005621_abnormal_cell_physiology0.67519990
153MP0009763_increased_sensitivity_to0.67186401
154MP0005266_abnormal_metabolism0.67031878
155MP0001542_abnormal_bone_strength0.65479281
156MP0002332_abnormal_exercise_endurance0.64463388
157MP0003119_abnormal_digestive_system0.64126290
158MP0000477_abnormal_intestine_morphology0.63095238
159MP0005394_taste/olfaction_phenotype0.62506090
160MP0005499_abnormal_olfactory_system0.62506090
161MP0005423_abnormal_somatic_nervous0.62237940
162MP0005645_abnormal_hypothalamus_physiol0.61767234
163MP0006292_abnormal_olfactory_placode0.60075384
164MP0005166_decreased_susceptibility_to0.59985310
165MP0001853_heart_inflammation0.59922437
166MP0000733_abnormal_muscle_development0.59829550
167MP0000015_abnormal_ear_pigmentation0.58456474

Predicted human phenotypes

RankGene SetZ-score
1Multiple enchondromatosis (HP:0005701)4.37625299
2Breast hypoplasia (HP:0003187)4.18820783
3Hyperglycinemia (HP:0002154)3.90462924
4Abnormality of cells of the erythroid lineage (HP:0012130)3.78976762
5Hyperglycinuria (HP:0003108)3.70883121
6Abnormal mitochondria in muscle tissue (HP:0008316)3.69855762
7Carpal bone hypoplasia (HP:0001498)3.69515368
8Birth length less than 3rd percentile (HP:0003561)3.64074390
9Acute necrotizing encephalopathy (HP:0006965)3.60311643
10Cerebral hypomyelination (HP:0006808)3.55778673
11Rough bone trabeculation (HP:0100670)3.48757591
12Abnormal number of erythroid precursors (HP:0012131)3.47668778
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.44117905
14Increased intramyocellular lipid droplets (HP:0012240)3.39766609
15Agammaglobulinemia (HP:0004432)3.33996196
16Mitochondrial inheritance (HP:0001427)3.33126268
17Progressive muscle weakness (HP:0003323)3.32640771
18Chronic obstructive pulmonary disease (HP:0006510)3.27879524
19Obstructive lung disease (HP:0006536)3.27879524
20Abnormality of glycine metabolism (HP:0010895)3.21457716
21Abnormality of serine family amino acid metabolism (HP:0010894)3.21457716
22Oral leukoplakia (HP:0002745)3.20275061
23Increased muscle lipid content (HP:0009058)3.19469453
24Abnormality of macrophages (HP:0004311)3.18665766
25Macrocytic anemia (HP:0001972)3.18056591
26Reticulocytopenia (HP:0001896)3.16173912
27Hepatocellular necrosis (HP:0001404)3.09665083
28Recurrent bacterial skin infections (HP:0005406)3.09065172
29Hypertensive crisis (HP:0100735)3.08801089
30Mediastinal lymphadenopathy (HP:0100721)3.06472759
31Degeneration of anterior horn cells (HP:0002398)3.04876685
32Abnormality of the anterior horn cell (HP:0006802)3.04876685
33Recurrent abscess formation (HP:0002722)2.99435269
34Trismus (HP:0000211)2.98720083
35Acute encephalopathy (HP:0006846)2.95268407
36Eczematoid dermatitis (HP:0000976)2.94336634
37Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.94064575
38Increased CSF lactate (HP:0002490)2.80879254
39Premature ovarian failure (HP:0008209)2.78638202
40Microretrognathia (HP:0000308)2.76759340
41Abnormality of serum amino acid levels (HP:0003112)2.76001240
42Respiratory difficulties (HP:0002880)2.73757388
43Progressive macrocephaly (HP:0004481)2.73112915
44Patellar aplasia (HP:0006443)2.72664143
45Aplasia/Hypoplasia of the patella (HP:0006498)2.71704432
46Exercise intolerance (HP:0003546)2.69566725
47Impulsivity (HP:0100710)2.69017825
48Nausea (HP:0002018)2.68607139
49Meningitis (HP:0001287)2.66249390
50Elevated erythrocyte sedimentation rate (HP:0003565)2.63415012
51Megaloblastic anemia (HP:0001889)2.62217772
52Abnormal gallbladder physiology (HP:0012438)2.61335319
53Cholecystitis (HP:0001082)2.61335319
54Increased IgM level (HP:0003496)2.58958347
55Panhypogammaglobulinemia (HP:0003139)2.58063919
56Selective tooth agenesis (HP:0001592)2.57692187
57Abnormality of the umbilical cord (HP:0010881)2.57098771
58Ragged-red muscle fibers (HP:0003200)2.55992936
59Gout (HP:0001997)2.55870194
60Renal Fanconi syndrome (HP:0001994)2.55034499
61Secondary amenorrhea (HP:0000869)2.50982475
62Petechiae (HP:0000967)2.48558212
63Abnormal trabecular bone morphology (HP:0100671)2.48335813
643-Methylglutaconic aciduria (HP:0003535)2.45807917
65Abnormality of glycolipid metabolism (HP:0010969)2.45200569
66Abnormality of liposaccharide metabolism (HP:0010968)2.45200569
67Abnormality of glycosphingolipid metabolism (HP:0004343)2.45200569
68Cellulitis (HP:0100658)2.44008596
69Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.43864174
70Ureteral duplication (HP:0000073)2.42488292
71Abnormality of pyrimidine metabolism (HP:0004353)2.39272689
72Hepatosplenomegaly (HP:0001433)2.38313163
73Abnormality of monocarboxylic acid metabolism (HP:0010996)2.37839017
74Death in infancy (HP:0001522)2.37461852
75Gastrointestinal stroma tumor (HP:0100723)2.36278842
76Abnormality of the heme biosynthetic pathway (HP:0010472)2.36069505
77Abnormal cartilage morphology (HP:0002763)2.35255805
78Lactic acidosis (HP:0003128)2.30362236
79Peripheral hypomyelination (HP:0007182)2.30216235
80Increased hepatocellular lipid droplets (HP:0006565)2.26513390
81Lymphopenia (HP:0001888)2.24051510
82Stomatitis (HP:0010280)2.23931861
83Hyperammonemia (HP:0001987)2.23325393
84Microvesicular hepatic steatosis (HP:0001414)2.21644080
85Pallor (HP:0000980)2.21350988
86Abnormality of dicarboxylic acid metabolism (HP:0010995)2.20172185
87Dicarboxylic aciduria (HP:0003215)2.20172185
88Sparse eyelashes (HP:0000653)2.18798473
89CNS demyelination (HP:0007305)2.18572124
90Neoplasm of the pancreas (HP:0002894)2.17444169
91Muscle fiber splitting (HP:0003555)2.16980585
92Personality changes (HP:0000751)2.15544649
93Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.15399235
94Myopathic facies (HP:0002058)2.15398243
95Purpura (HP:0000979)2.14852347
96Colon cancer (HP:0003003)2.13704743
97Rhabdomyolysis (HP:0003201)2.10539609
98Dysphonia (HP:0001618)2.09717201
99Decreased activity of mitochondrial respiratory chain (HP:0008972)2.09676712
100Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.09676712
101Areflexia of lower limbs (HP:0002522)2.09643316
102Urticaria (HP:0001025)2.09441643
103Progressive external ophthalmoplegia (HP:0000590)2.07313706
104Hypobetalipoproteinemia (HP:0003563)2.06870477
105Abnormality of fatty-acid metabolism (HP:0004359)2.06291701
106Aplasia/Hypoplasia involving the musculature (HP:0001460)2.05855971
107Abnormality of aromatic amino acid family metabolism (HP:0004338)2.05396036
108Lethargy (HP:0001254)2.05371734
109Pustule (HP:0200039)2.04765490
110Vacuolated lymphocytes (HP:0001922)2.03328858
111Absent radius (HP:0003974)2.03251255
112IgM deficiency (HP:0002850)2.02571033
113Emotional lability (HP:0000712)2.02520840
114Thrombocytosis (HP:0001894)2.02298248
115Absent thumb (HP:0009777)2.01997029
116Progressive neurologic deterioration (HP:0002344)2.00696996
117Ependymoma (HP:0002888)2.00629566
118Abnormality of cells of the lymphoid lineage (HP:0012140)1.99107787
119Cerebral edema (HP:0002181)1.99058061
120Deep palmar crease (HP:0006191)1.98814911
121CNS hypomyelination (HP:0003429)1.98510602
122Respiratory failure (HP:0002878)1.97110588
123Seborrheic dermatitis (HP:0001051)1.95829737
124Muscle fiber atrophy (HP:0100295)1.95716315
125Abnormal delayed hypersensitivity skin test (HP:0002963)1.94594478
126Difficulty climbing stairs (HP:0003551)1.94239750
127Exertional dyspnea (HP:0002875)1.93897118
128Prolonged neonatal jaundice (HP:0006579)1.93844413
129Recurrent fungal infections (HP:0002841)1.93251727
130Lipid accumulation in hepatocytes (HP:0006561)1.92300151
131Recurrent viral infections (HP:0004429)1.90648514
132Abnormality of the motor neurons (HP:0002450)1.90425634
133Abnormal neuron morphology (HP:0012757)1.90425634
134Entropion (HP:0000621)1.89308165
135Encephalitis (HP:0002383)1.88679455
136Mutism (HP:0002300)1.88306667
137Abnormality of the distal phalanges of the toes (HP:0010182)1.87976460
138Axonal loss (HP:0003447)1.87695985
139Gastrointestinal inflammation (HP:0004386)1.84005636
140Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83904876
141Abnormality of alanine metabolism (HP:0010916)1.83904876
142Hyperalaninemia (HP:0003348)1.83904876
143Aplasia involving forearm bones (HP:0009822)1.83127744
144Absent forearm bone (HP:0003953)1.83127744
145Migraine (HP:0002076)1.83125685
146Colitis (HP:0002583)1.82802011
147Aplastic anemia (HP:0001915)1.82450970
148Xanthomatosis (HP:0000991)1.81826483
149Recurrent skin infections (HP:0001581)1.81603526
150Hepatic necrosis (HP:0002605)1.81047831
151Poor head control (HP:0002421)1.80476884
152Squamous cell carcinoma (HP:0002860)1.80065326
153Increased serum lactate (HP:0002151)1.79634587
154Spastic diplegia (HP:0001264)1.79508239
155Disinhibition (HP:0000734)1.79266331
156Abnormality of reticulocytes (HP:0004312)1.77717875
157Hyperthyroidism (HP:0000836)1.77445380
158Myositis (HP:0100614)1.77188662
159Neuronal loss in central nervous system (HP:0002529)1.76656620
160Atrophy/Degeneration involving motor neurons (HP:0007373)1.75745149
161Calcaneovalgus deformity (HP:0001848)1.75274371
162Recurrent gram-negative bacterial infections (HP:0005420)1.74304319
163Patent foramen ovale (HP:0001655)1.74072095
164Bone marrow hypocellularity (HP:0005528)1.72578118
165Abnormalities of placenta or umbilical cord (HP:0001194)1.72227857
166Polycythemia (HP:0001901)1.71642584
167Verrucae (HP:0200043)1.71557683
168Increased serum ferritin (HP:0003281)1.71206988
169Testicular atrophy (HP:0000029)1.71153247
170Aplasia/Hypoplasia of the sacrum (HP:0008517)1.70404348
171Spastic paraparesis (HP:0002313)1.70291711
172Muscle fibrillation (HP:0010546)1.70094921
173Deformed tarsal bones (HP:0008119)1.69943633
174Atrioventricular block (HP:0001678)1.69159782
175Meckel diverticulum (HP:0002245)1.66839164
176Abnormal hemoglobin (HP:0011902)1.66624205
177Aplasia/hypoplasia of the humerus (HP:0006507)1.65955161
178Premature graying of hair (HP:0002216)1.65432944
179Abnormality of sulfur amino acid metabolism (HP:0004339)1.63060456
180Glossoptosis (HP:0000162)1.62438637
181Horseshoe kidney (HP:0000085)1.61194484
182Cellular immunodeficiency (HP:0005374)1.60699677

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.09695858
2WEE14.04505531
3VRK23.73806780
4NME23.63360547
5CDK193.21565662
6EPHA22.98950729
7NEK22.61991983
8EIF2AK12.57221981
9BCKDK2.41139927
10SIK22.27457056
11NEK12.26118098
12STK162.24995666
13TESK22.13079824
14DYRK32.06189255
15TSSK62.05884797
16TTK2.04433144
17SIK31.91743166
18SMG11.85776301
19PLK41.80322403
20PRPF4B1.76518864
21CDC71.69987216
22PLK11.69000052
23SRPK11.64211498
24TBK11.62038307
25PIM21.57852062
26ACVR1B1.54585352
27BRSK21.53537381
28IRAK41.52321484
29RPS6KA41.47290459
30RIPK41.43588988
31RPS6KB21.43376535
32MAP3K81.38354287
33ZAK1.37744473
34EIF2AK31.35459534
35TRIB31.32816886
36CDK71.32782929
37AURKB1.31015665
38MOS1.28969266
39MAP3K111.22569807
40CDK41.22254893
41CSK1.18993857
42MARK31.17673087
43AURKA1.17539770
44PDK41.16654784
45PDK31.16654784
46PAK41.13104087
47AKT31.11962109
48TLK11.09794727
49TAOK11.09772203
50EPHB21.09083286
51KDR1.09026751
52LRRK21.08726406
53SIK11.04340657
54CHEK21.03620378
55STK101.03486437
56IKBKE1.03475216
57PKN20.94722189
58ICK0.94588242
59PIM10.93672979
60FES0.93569226
61JAK30.93395056
62MAP2K20.93393517
63BRSK10.93136170
64MATK0.93103497
65IRAK30.92011529
66STK40.91937960
67CSF1R0.90897288
68PLK30.90678139
69PINK10.88402769
70EEF2K0.87360344
71BRAF0.87293130
72BTK0.86748961
73MAP3K100.86084917
74ATR0.86047613
75PDK20.85045488
76ABL20.84399388
77ARAF0.82983253
78NME10.82408395
79MAP2K30.81623919
80SCYL20.80824550
81VRK10.79282559
82TNK20.79064802
83CLK10.78190060
84ERN10.78095245
85PAK10.78063637
86PASK0.76761356
87MAP3K130.76695157
88MAPKAPK30.76110422
89LIMK10.75973364
90FGR0.75481115
91ALK0.75476712
92SYK0.75074246
93STK38L0.74727486
94MARK20.73759179
95CHEK10.73560439
96MAP3K30.72348850
97LYN0.72002916
98STK30.71938334
99DAPK30.71073786
100LATS20.69388274
101PRKCI0.68533165
102TESK10.68226902
103CDK120.68031794
104FLT30.66758531
105TGFBR10.66104011
106CSNK2A20.63334667
107BMX0.61818585
108MKNK10.61611973
109CSNK2A10.61088933
110MAP4K10.60825622
111BLK0.60757979
112CDK11A0.60558144
113DAPK10.60252626
114RPS6KL10.55166118
115RPS6KC10.55166118
116PNCK0.55151920
117* CDK20.54573310
118MTOR0.53081195
119TYK20.51792001
120RPS6KA50.51529950
121ILK0.51352751
122IRAK20.50656530
123TTN0.50165785
124ZAP700.49585231
125MAPK120.49395300
126CDK60.48574168
127LCK0.48102505
128CDK140.47612577
129FGFR40.47290739
130CCNB10.46633116
131MAP4K20.43877993
132MAPK40.42978784
133AKT20.42729280
134TAOK20.41656395
135TXK0.41294952
136MAP3K10.40856807
137PBK0.39977467
138HCK0.39235249
139GRK60.39174019
140HIPK20.38747848
141CDK150.37625310
142MAPK110.37262436
143PRKCQ0.36588051
144CSNK1E0.36289930
145RPS6KA60.36057161
146DYRK20.35517381
147ITK0.35374533
148PRKD20.35285883
149PKN10.34945861
150IKBKB0.32962687
151ATM0.31279790
152DYRK1B0.31000357

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.68175607
2Ribosome_Homo sapiens_hsa030103.36543044
3DNA replication_Homo sapiens_hsa030303.34732696
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.16331312
5RNA polymerase_Homo sapiens_hsa030203.14996141
6Oxidative phosphorylation_Homo sapiens_hsa001902.98466393
7Vitamin B6 metabolism_Homo sapiens_hsa007502.82567475
8Mismatch repair_Homo sapiens_hsa034302.62198556
9RNA transport_Homo sapiens_hsa030132.60080534
10Spliceosome_Homo sapiens_hsa030402.47934608
11Primary immunodeficiency_Homo sapiens_hsa053402.32485739
12Pyrimidine metabolism_Homo sapiens_hsa002402.24214308
13Folate biosynthesis_Homo sapiens_hsa007902.19245042
14Base excision repair_Homo sapiens_hsa034102.17084955
15Allograft rejection_Homo sapiens_hsa053302.11398836
16One carbon pool by folate_Homo sapiens_hsa006702.00760042
17Nucleotide excision repair_Homo sapiens_hsa034201.95942636
18Homologous recombination_Homo sapiens_hsa034401.91341502
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.88951856
20Autoimmune thyroid disease_Homo sapiens_hsa053201.83472754
21Sulfur relay system_Homo sapiens_hsa041221.82948860
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.82593699
23Graft-versus-host disease_Homo sapiens_hsa053321.80767194
24Pentose phosphate pathway_Homo sapiens_hsa000301.79868448
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74965506
26Asthma_Homo sapiens_hsa053101.72955431
27Cell cycle_Homo sapiens_hsa041101.71982404
28Alzheimers disease_Homo sapiens_hsa050101.65416739
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.61746275
30Other glycan degradation_Homo sapiens_hsa005111.60482742
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59467440
32Biosynthesis of amino acids_Homo sapiens_hsa012301.55490258
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.54434948
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.52866102
35Leishmaniasis_Homo sapiens_hsa051401.47514104
36Type I diabetes mellitus_Homo sapiens_hsa049401.46300816
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.44217161
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41628567
39Rheumatoid arthritis_Homo sapiens_hsa053231.39585615
40Carbon metabolism_Homo sapiens_hsa012001.35029614
41Viral myocarditis_Homo sapiens_hsa054161.34128284
42Osteoclast differentiation_Homo sapiens_hsa043801.31911915
43Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.30993171
44Selenocompound metabolism_Homo sapiens_hsa004501.30787932
45B cell receptor signaling pathway_Homo sapiens_hsa046621.30391387
46p53 signaling pathway_Homo sapiens_hsa041151.26199037
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.21076506
48Shigellosis_Homo sapiens_hsa051311.20517823
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19140437
50Salmonella infection_Homo sapiens_hsa051321.16082590
51Fructose and mannose metabolism_Homo sapiens_hsa000511.15279729
52Basal transcription factors_Homo sapiens_hsa030221.14371704
53Glutathione metabolism_Homo sapiens_hsa004801.12606339
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10117002
55Acute myeloid leukemia_Homo sapiens_hsa052211.09153956
56Purine metabolism_Homo sapiens_hsa002301.08852776
57Tuberculosis_Homo sapiens_hsa051521.07882381
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07643973
59Collecting duct acid secretion_Homo sapiens_hsa049661.06122694
60Fanconi anemia pathway_Homo sapiens_hsa034601.02902153
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01681926
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00991827
63Regulation of autophagy_Homo sapiens_hsa041401.00435214
64Fatty acid elongation_Homo sapiens_hsa000620.99997131
65Phagosome_Homo sapiens_hsa041450.98826474
66Hematopoietic cell lineage_Homo sapiens_hsa046400.95246471
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95101463
68Cardiac muscle contraction_Homo sapiens_hsa042600.94544377
69Epstein-Barr virus infection_Homo sapiens_hsa051690.92752792
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92607102
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92484363
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91027727
73RNA degradation_Homo sapiens_hsa030180.90446138
74Staphylococcus aureus infection_Homo sapiens_hsa051500.89658993
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89158853
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88315492
77mRNA surveillance pathway_Homo sapiens_hsa030150.87101593
78Arginine and proline metabolism_Homo sapiens_hsa003300.86601471
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84245242
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.83374833
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.83154877
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78929199
83T cell receptor signaling pathway_Homo sapiens_hsa046600.78616966
84Notch signaling pathway_Homo sapiens_hsa043300.77851970
85Fatty acid degradation_Homo sapiens_hsa000710.76959865
86Arginine biosynthesis_Homo sapiens_hsa002200.75100973
87Galactose metabolism_Homo sapiens_hsa000520.74803557
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74601630
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74328047
90Measles_Homo sapiens_hsa051620.73855728
91Vitamin digestion and absorption_Homo sapiens_hsa049770.69592401
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68780435
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66379036
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66137363
95Vibrio cholerae infection_Homo sapiens_hsa051100.66033033
96beta-Alanine metabolism_Homo sapiens_hsa004100.65949963
97Non-homologous end-joining_Homo sapiens_hsa034500.65911856
98Malaria_Homo sapiens_hsa051440.64533597
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64305972
100Influenza A_Homo sapiens_hsa051640.62765766
101Systemic lupus erythematosus_Homo sapiens_hsa053220.61325587
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60964371
103Antigen processing and presentation_Homo sapiens_hsa046120.59680673
104Propanoate metabolism_Homo sapiens_hsa006400.58790442
105Peroxisome_Homo sapiens_hsa041460.56856586
106Metabolic pathways_Homo sapiens_hsa011000.56094279
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55972283
108Chemokine signaling pathway_Homo sapiens_hsa040620.54185969
109Chemical carcinogenesis_Homo sapiens_hsa052040.51448221
110Pyruvate metabolism_Homo sapiens_hsa006200.51181630
111Tryptophan metabolism_Homo sapiens_hsa003800.50695804
112Pertussis_Homo sapiens_hsa051330.50233817
113Viral carcinogenesis_Homo sapiens_hsa052030.48097334
114Endocytosis_Homo sapiens_hsa041440.47262945
115Toxoplasmosis_Homo sapiens_hsa051450.45758573
116Fat digestion and absorption_Homo sapiens_hsa049750.45451922
117Nitrogen metabolism_Homo sapiens_hsa009100.45405527
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45018826
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44283419
120Caffeine metabolism_Homo sapiens_hsa002320.44072816
121Legionellosis_Homo sapiens_hsa051340.43659510
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.43602601
123Herpes simplex infection_Homo sapiens_hsa051680.43188406
124Huntingtons disease_Homo sapiens_hsa050160.43017757
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42887697
126Retinol metabolism_Homo sapiens_hsa008300.40927613
127Fatty acid metabolism_Homo sapiens_hsa012120.40104841
128VEGF signaling pathway_Homo sapiens_hsa043700.39778775
129Parkinsons disease_Homo sapiens_hsa050120.37405193
130Butanoate metabolism_Homo sapiens_hsa006500.36878649
131PPAR signaling pathway_Homo sapiens_hsa033200.36791455
132Prion diseases_Homo sapiens_hsa050200.36671235
133Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36563448
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36098748
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35849271
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34979643
137HIF-1 signaling pathway_Homo sapiens_hsa040660.34512780
138Hepatitis B_Homo sapiens_hsa051610.34271566
139Protein export_Homo sapiens_hsa030600.34059535
140TNF signaling pathway_Homo sapiens_hsa046680.33321207
141Complement and coagulation cascades_Homo sapiens_hsa046100.32637359
142Phenylalanine metabolism_Homo sapiens_hsa003600.32337299
143Glycosaminoglycan degradation_Homo sapiens_hsa005310.32010432
144Thyroid cancer_Homo sapiens_hsa052160.31044927
145Oocyte meiosis_Homo sapiens_hsa041140.29414616
146Small cell lung cancer_Homo sapiens_hsa052220.29405768
147Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28762001
148Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28498578
149Histidine metabolism_Homo sapiens_hsa003400.28448405
150Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27072529
151Apoptosis_Homo sapiens_hsa042100.26971002
152Bladder cancer_Homo sapiens_hsa052190.25590876
153HTLV-I infection_Homo sapiens_hsa051660.24372722
154Steroid hormone biosynthesis_Homo sapiens_hsa001400.23857007
155Lysosome_Homo sapiens_hsa041420.23227924

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