UBR5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.16967081
2nuclear pore organization (GO:0006999)6.67259928
3pore complex assembly (GO:0046931)5.26554792
4mitotic sister chromatid cohesion (GO:0007064)5.18965408
5pre-miRNA processing (GO:0031054)5.02544303
6regulation of RNA export from nucleus (GO:0046831)4.48601502
7regulation of histone H3-K9 methylation (GO:0051570)4.44474593
8negative regulation of histone methylation (GO:0031061)4.34911497
9cilium or flagellum-dependent cell motility (GO:0001539)4.24813862
10histone H3-K36 demethylation (GO:0070544)4.22299387
11piRNA metabolic process (GO:0034587)4.21329042
12heterochromatin organization (GO:0070828)4.21043152
13gene silencing by RNA (GO:0031047)4.11579286
14NLS-bearing protein import into nucleus (GO:0006607)4.01217435
15synaptonemal complex assembly (GO:0007130)3.98906126
16regulation of gene silencing by RNA (GO:0060966)3.95363047
17regulation of posttranscriptional gene silencing (GO:0060147)3.95363047
18regulation of gene silencing by miRNA (GO:0060964)3.95363047
19regulation of centriole replication (GO:0046599)3.95029810
20monoubiquitinated protein deubiquitination (GO:0035520)3.77607318
21regulation of histone H3-K27 methylation (GO:0061085)3.75609532
22synaptonemal complex organization (GO:0070193)3.74390592
23mitotic nuclear envelope disassembly (GO:0007077)3.69335126
24regulation of nucleobase-containing compound transport (GO:0032239)3.68001686
25positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.66606967
26male meiosis (GO:0007140)3.65740432
27phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.61518040
28peptidyl-lysine dimethylation (GO:0018027)3.60775799
29nuclear envelope disassembly (GO:0051081)3.58350977
30membrane disassembly (GO:0030397)3.58350977
31paraxial mesoderm development (GO:0048339)3.58276717
32histone H3-K4 trimethylation (GO:0080182)3.57748427
33regulation of translational fidelity (GO:0006450)3.56229518
34DNA synthesis involved in DNA repair (GO:0000731)3.55077670
35positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.54762936
36positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.54762936
37positive regulation of mitotic sister chromatid separation (GO:1901970)3.54762936
38cytoplasmic mRNA processing body assembly (GO:0033962)3.53252039
39gene silencing (GO:0016458)3.51281025
40interkinetic nuclear migration (GO:0022027)3.50293063
41chromatin assembly (GO:0031497)3.47636604
42regulation of sister chromatid cohesion (GO:0007063)3.46528559
43DNA replication-dependent nucleosome assembly (GO:0006335)3.44198597
44DNA replication-dependent nucleosome organization (GO:0034723)3.44198597
45mitotic chromosome condensation (GO:0007076)3.40250408
46DNA topological change (GO:0006265)3.39387824
47sister chromatid segregation (GO:0000819)3.37483637
48DNA duplex unwinding (GO:0032508)3.33921815
49DNA geometric change (GO:0032392)3.33543224
50histone H2A monoubiquitination (GO:0035518)3.32714046
51regulation of histone methylation (GO:0031060)3.32680492
52chaperone-mediated protein complex assembly (GO:0051131)3.30333483
53peptidyl-lysine trimethylation (GO:0018023)3.28519959
54* negative regulation of DNA repair (GO:0045738)3.28027859
55regulation of translational termination (GO:0006449)3.26167377
56histone H3-K9 demethylation (GO:0033169)3.26098536
57protein localization to kinetochore (GO:0034501)3.24288610
58spindle assembly involved in mitosis (GO:0090307)3.23001572
59regulation of mitotic spindle organization (GO:0060236)3.21514507
60positive regulation of SMAD protein import into nucleus (GO:0060391)3.20358135
61negative regulation of translation, ncRNA-mediated (GO:0040033)3.20160328
62regulation of translation, ncRNA-mediated (GO:0045974)3.20160328
63negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.20160328
64dosage compensation (GO:0007549)3.18865349
65regulation of histone H3-K4 methylation (GO:0051569)3.18278870
66nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.15905888
67RNA stabilization (GO:0043489)3.15029021
68mRNA stabilization (GO:0048255)3.15029021
69regulation of NFAT protein import into nucleus (GO:0051532)3.13099103
70negative regulation of organelle assembly (GO:1902116)3.10367838
71positive regulation of chromosome segregation (GO:0051984)3.09676732
72histone H3-K4 methylation (GO:0051568)3.07049332
73sister chromatid cohesion (GO:0007062)3.06714634
74peptidyl-lysine methylation (GO:0018022)3.05599684
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.05556609
76protein localization to chromosome, centromeric region (GO:0071459)3.05483386
77regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.04437816
78embryonic camera-type eye morphogenesis (GO:0048596)3.03792306
79DNA unwinding involved in DNA replication (GO:0006268)3.00550788
80regulation of centrosome cycle (GO:0046605)2.97120261
81histone H3-K9 methylation (GO:0051567)2.96592678
82regulation of meiosis I (GO:0060631)2.96555076
83regulation of spindle organization (GO:0090224)2.96554293
84mitotic sister chromatid segregation (GO:0000070)2.96069974
85histone lysine methylation (GO:0034968)2.95239822
86translesion synthesis (GO:0019985)2.92202246
87fusion of sperm to egg plasma membrane (GO:0007342)2.91571990
88chromosome organization involved in meiosis (GO:0070192)2.89578361
89spliceosomal tri-snRNP complex assembly (GO:0000244)2.88860417
90regulation of hippo signaling (GO:0035330)2.88506291
91regulation of centrosome duplication (GO:0010824)2.88035818
92microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.87852122
93double-strand break repair via nonhomologous end joining (GO:0006303)2.86024465
94non-recombinational repair (GO:0000726)2.86024465
95protein export from nucleus (GO:0006611)2.85676650
96determination of adult lifespan (GO:0008340)2.84842843
97nucleus organization (GO:0006997)2.83859868
98nuclear envelope organization (GO:0006998)2.83803569
99positive regulation of cell cycle checkpoint (GO:1901978)2.83768452
100DNA replication initiation (GO:0006270)2.81393126
101histone lysine demethylation (GO:0070076)2.81269576
102chromatin silencing (GO:0006342)2.80372016
103genitalia morphogenesis (GO:0035112)2.78994059
104acrosome assembly (GO:0001675)2.77085022
105chromosome condensation (GO:0030261)2.76109259
106corticosteroid receptor signaling pathway (GO:0031958)2.75752403
107negative regulation of fibroblast apoptotic process (GO:2000270)2.74699281
108meiotic nuclear division (GO:0007126)2.74157812
109regulation of helicase activity (GO:0051095)2.74013420
110protein dealkylation (GO:0008214)2.73919310
111protein demethylation (GO:0006482)2.73919310
112anterior/posterior axis specification, embryo (GO:0008595)2.73914032
113histone H4-K12 acetylation (GO:0043983)2.73854800
114hippo signaling (GO:0035329)2.73571966
115regulation of SMAD protein import into nucleus (GO:0060390)2.73506210
116glucocorticoid receptor signaling pathway (GO:0042921)2.73424559
117regulation of establishment of cell polarity (GO:2000114)2.72996501
118binding of sperm to zona pellucida (GO:0007339)2.72368511
119DNA conformation change (GO:0071103)2.71307970
120establishment of apical/basal cell polarity (GO:0035089)2.70624551
121peptidyl-threonine phosphorylation (GO:0018107)2.70522056
122stress granule assembly (GO:0034063)2.70420214
123histone demethylation (GO:0016577)2.69319337
124positive regulation of histone methylation (GO:0031062)2.69275552
125positive regulation of histone H3-K4 methylation (GO:0051571)2.68741963
126regulation of DNA endoreduplication (GO:0032875)2.67369335
127spermatid development (GO:0007286)2.67350251
128sperm-egg recognition (GO:0035036)2.66459990
129positive regulation of DNA-templated transcription, initiation (GO:2000144)2.65590448
130histone H3-K9 modification (GO:0061647)2.64997038
131histone H4-K5 acetylation (GO:0043981)2.64840144
132histone H4-K8 acetylation (GO:0043982)2.64840144
133DNA packaging (GO:0006323)2.63451115
134DNA alkylation (GO:0006305)2.62691323
135DNA methylation (GO:0006306)2.62691323
136mRNA transport (GO:0051028)2.62562113
137DNA methylation involved in gamete generation (GO:0043046)2.62176725
138peptidyl-threonine modification (GO:0018210)2.62081221
139embryonic eye morphogenesis (GO:0048048)2.61821530
140histone H4-K16 acetylation (GO:0043984)2.60710295
141histone methylation (GO:0016571)2.56549891
142histone H2B ubiquitination (GO:0033523)2.56125181
143insulin-like growth factor receptor signaling pathway (GO:0048009)2.55002083
144regulation of DNA damage checkpoint (GO:2000001)2.53892017
145* protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.52757134
146somatic hypermutation of immunoglobulin genes (GO:0016446)2.50599219
147somatic diversification of immune receptors via somatic mutation (GO:0002566)2.50599219
148regulation of chromatin binding (GO:0035561)2.49831018
149trophectodermal cell differentiation (GO:0001829)2.48091000

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.67055697
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.42699370
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.22316284
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.13762908
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.65228803
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.46078406
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.15487805
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00383581
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.80404150
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.53781279
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.43647408
12* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.32761671
13SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.21365401
14ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.16879637
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.15520767
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.15520767
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.15520767
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.11039947
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10771010
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09768512
21AR_21909140_ChIP-Seq_LNCAP_Human2.03129396
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.00869782
23E2F1_21310950_ChIP-Seq_MCF-7_Human1.97376703
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.93668381
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92341637
26* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.90457792
27GATA1_22025678_ChIP-Seq_K562_Human1.88050540
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.82566685
29MYC_22102868_ChIP-Seq_BL_Human1.82258619
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.79230141
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.76270409
32NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.68094061
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.67944346
34* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.66275989
35NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.64583952
36TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.61972327
37ZNF263_19887448_ChIP-Seq_K562_Human1.60300223
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.55964746
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.55525802
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.55493312
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55114289
42* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.50657281
43TCF3_18692474_ChIP-Seq_MESCs_Mouse1.50367318
44CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48257440
45CTNNB1_20460455_ChIP-Seq_HCT116_Human1.47499955
46ZFP281_27345836_Chip-Seq_ESCs_Mouse1.46973412
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45867104
48DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.45010704
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.44367825
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43425539
51NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.42396286
52AHR_22903824_ChIP-Seq_MCF-7_Human1.40342388
53PKCTHETA_26484144_Chip-Seq_BREAST_Human1.38034265
54FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.36945242
55NANOG_21062744_ChIP-ChIP_HESCs_Human1.34544444
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34389660
57SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.31398425
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30038994
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29411824
60* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.29165763
61POU5F1_16518401_ChIP-PET_MESCs_Mouse1.28855024
62* TCF7_22412390_ChIP-Seq_EML_Mouse1.27734853
63TCF3_18692474_ChIP-Seq_MEFs_Mouse1.24613849
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24178305
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23101161
66MYC_18555785_ChIP-Seq_MESCs_Mouse1.22372939
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22100838
68ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20273298
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19515217
70TBX3_20139965_ChIP-Seq_ESCs_Mouse1.18745226
71KDM2B_26808549_Chip-Seq_DND41_Human1.18712293
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.18500286
73EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17037500
74FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16770154
75TBX3_20139965_ChIP-Seq_MESCs_Mouse1.16749866
76STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.16658368
77POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.16360589
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15682662
79NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15400953
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.13870957
81AR_21572438_ChIP-Seq_LNCaP_Human1.13857680
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12047993
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11541110
84SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.10736415
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09250811
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08917935
87POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08559357
88NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07164907
89TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.06603085
90PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05866830
91CHD1_26751641_Chip-Seq_LNCaP_Human1.05708066
92P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05015361
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.04661443
94FUS_26573619_Chip-Seq_HEK293_Human1.04517346
95CLOCK_20551151_ChIP-Seq_293T_Human1.04308895
96KDM5A_27292631_Chip-Seq_BREAST_Human1.03996026
97SOX2_18692474_ChIP-Seq_MESCs_Mouse1.03796341
98PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.01719368
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00384909
100FOXO3_23340844_ChIP-Seq_DLD1_Human1.00150391
101EWS_26573619_Chip-Seq_HEK293_Human0.99369719
102SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98674025
103FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.97891152
104SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96414240
105SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96414240
106TP53_16413492_ChIP-PET_HCT116_Human0.96211137
107SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95568198
108* STAT3_23295773_ChIP-Seq_U87_Human0.95376765
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95317697
110TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95175747
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95068739
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94983600
113BRD4_25478319_ChIP-Seq_HGPS_Human0.94776265
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93949206
115NANOG_16518401_ChIP-PET_MESCs_Mouse0.93908823
116NANOG_18692474_ChIP-Seq_MESCs_Mouse0.93875832
117GATA1_26923725_Chip-Seq_HPCs_Mouse0.93597477
118YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91134566
119ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90940012
120MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89356919
121* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89345786
122NCOR1_26117541_ChIP-Seq_K562_Human0.89265440
123FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.89176345
124MYC_19030024_ChIP-ChIP_MESCs_Mouse0.88584160
125SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88362970
126CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88156946
127* FOXA2_19822575_ChIP-Seq_HepG2_Human0.87716120
128ISL1_27105846_Chip-Seq_CPCs_Mouse0.87710760
129KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86684645
130ATF3_27146783_Chip-Seq_COLON_Human0.86019660
131NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.85429688
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85356888
133* MYB_26560356_Chip-Seq_TH1_Human0.84361260
134NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83296155
135CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82014811
136CIITA_25753668_ChIP-Seq_RAJI_Human0.81987387
137* SOX9_26525672_Chip-Seq_HEART_Mouse0.81046912
138MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.80641517
139WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.80386052
140KDM2B_26808549_Chip-Seq_JURKAT_Human0.79995544
141ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79909724
142SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.79684769
143ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.79207593
144MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.77757310
145TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.77727486
146* TCF4_23295773_ChIP-Seq_U87_Human0.76970350
147STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.76743429
148TFEB_21752829_ChIP-Seq_HELA_Human0.76580286

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia4.00516257
2MP0003705_abnormal_hypodermis_morpholog3.65137024
3MP0010352_gastrointestinal_tract_polyps3.33858485
4MP0005076_abnormal_cell_differentiation2.99409379
5MP0008877_abnormal_DNA_methylation2.96807324
6MP0010307_abnormal_tumor_latency2.89903257
7MP0010094_abnormal_chromosome_stability2.75596335
8MP0008057_abnormal_DNA_replication2.69309400
9MP0000569_abnormal_digit_pigmentation2.65906157
10MP0003111_abnormal_nucleus_morphology2.62128452
11MP0005410_abnormal_fertilization2.42844381
12MP0005623_abnormal_meninges_morphology2.31982317
13MP0003077_abnormal_cell_cycle2.15797328
14MP0001730_embryonic_growth_arrest2.14622000
15MP0002396_abnormal_hematopoietic_system2.10827330
16MP0002166_altered_tumor_susceptibility2.10563455
17MP0002653_abnormal_ependyma_morphology2.09697772
18MP0004197_abnormal_fetal_growth/weight/2.06271431
19MP0010234_abnormal_vibrissa_follicle1.99113294
20* MP0002084_abnormal_developmental_patter1.98659968
21MP0004957_abnormal_blastocyst_morpholog1.93621057
22MP0000383_abnormal_hair_follicle1.84475818
23MP0003890_abnormal_embryonic-extraembry1.82889972
24MP0010678_abnormal_skin_adnexa1.80373784
25* MP0005380_embryogenesis_phenotype1.80305492
26* MP0001672_abnormal_embryogenesis/_devel1.80305492
27MP0001929_abnormal_gametogenesis1.70854432
28* MP0000350_abnormal_cell_proliferation1.70700016
29MP0000537_abnormal_urethra_morphology1.69464156
30* MP0002086_abnormal_extraembryonic_tissu1.69376171
31* MP0003984_embryonic_growth_retardation1.69103163
32* MP0002088_abnormal_embryonic_growth/wei1.68182769
33MP0003283_abnormal_digestive_organ1.66082918
34* MP0002085_abnormal_embryonic_tissue1.66044412
35MP0003566_abnormal_cell_adhesion1.63309501
36MP0000733_abnormal_muscle_development1.61185462
37MP0003123_paternal_imprinting1.60091114
38MP0002210_abnormal_sex_determination1.59993184
39MP0001293_anophthalmia1.58399954
40* MP0001697_abnormal_embryo_size1.58019798
41MP0004233_abnormal_muscle_weight1.57679920
42MP0003698_abnormal_male_reproductive1.55789618
43MP0008007_abnormal_cellular_replicative1.53797555
44MP0001849_ear_inflammation1.50886811
45MP0003693_abnormal_embryo_hatching1.48810241
46MP0002006_tumorigenesis1.45477349
47MP0003121_genomic_imprinting1.44283023
48MP0001145_abnormal_male_reproductive1.42011517
49MP0009703_decreased_birth_body1.39919756
50MP0004185_abnormal_adipocyte_glucose1.39690154
51MP0009697_abnormal_copulation1.37278306
52MP0002877_abnormal_melanocyte_morpholog1.34270817
53* MP0002080_prenatal_lethality1.32946436
54MP0008058_abnormal_DNA_repair1.32192564
55MP0003115_abnormal_respiratory_system1.29691677
56MP0009053_abnormal_anal_canal1.29036420
57MP0000428_abnormal_craniofacial_morphol1.27107300
58MP0003119_abnormal_digestive_system1.25258952
59MP0009672_abnormal_birth_weight1.22882564
60MP0005409_darkened_coat_color1.22864532
61MP0003787_abnormal_imprinting1.22571022
62MP0008438_abnormal_cutaneous_collagen1.21588418
63MP0003567_abnormal_fetal_cardiomyocyte1.20857941
64MP0003763_abnormal_thymus_physiology1.19462827
65MP0005187_abnormal_penis_morphology1.18829579
66MP0002697_abnormal_eye_size1.17744615
67MP0005666_abnormal_adipose_tissue1.16778320
68MP0000653_abnormal_sex_gland1.16345445
69MP0002092_abnormal_eye_morphology1.15598852
70MP0001915_intracranial_hemorrhage1.11879838
71MP0003300_gastrointestinal_ulcer1.11658068
72MP0001661_extended_life_span1.10749907
73MP0003045_fibrosis1.10602787
74MP0004084_abnormal_cardiac_muscle1.09022431
75* MP0002925_abnormal_cardiovascular_devel1.07883673
76MP0003937_abnormal_limbs/digits/tail_de1.06772769
77MP0000432_abnormal_head_morphology1.05933525
78MP0003943_abnormal_hepatobiliary_system1.05468250
79MP0005023_abnormal_wound_healing1.04568654
80MP0010630_abnormal_cardiac_muscle1.04284357
81MP0003221_abnormal_cardiomyocyte_apopto1.03403153
82MP0004808_abnormal_hematopoietic_stem1.02695410
83MP0004264_abnormal_extraembryonic_tissu1.01187990
84MP0003091_abnormal_cell_migration1.00463834
85MP0005451_abnormal_body_composition1.00443100
86* MP0003935_abnormal_craniofacial_develop0.99725078
87MP0003786_premature_aging0.98535360
88MP0000377_abnormal_hair_follicle0.98165887
89MP0010030_abnormal_orbit_morphology0.96697304
90MP0002161_abnormal_fertility/fecundity0.96660715
91MP0002269_muscular_atrophy0.95969347
92MP0002796_impaired_skin_barrier0.94364463
93MP0009278_abnormal_bone_marrow0.93549325
94MP0000427_abnormal_hair_cycle0.93329169
95MP0005375_adipose_tissue_phenotype0.92375013
96MP0001299_abnormal_eye_distance/0.92311289
97MP0008961_abnormal_basal_metabolism0.90714621
98MP0005275_abnormal_skin_tensile0.89460306
99MP0004272_abnormal_basement_membrane0.88706043
100* MP0003861_abnormal_nervous_system0.88313323
101MP0001286_abnormal_eye_development0.88104649
102MP0005384_cellular_phenotype0.87661121
103* MP0000266_abnormal_heart_morphology0.86737619
104MP0008932_abnormal_embryonic_tissue0.86580555
105MP0005220_abnormal_exocrine_pancreas0.86376185
106MP0003453_abnormal_keratinocyte_physiol0.85905123
107MP0004087_abnormal_muscle_fiber0.85058214
108MP0000003_abnormal_adipose_tissue0.83252400
109MP0003941_abnormal_skin_development0.83041831
110MP0005248_abnormal_Harderian_gland0.82599309
111MP0000703_abnormal_thymus_morphology0.79697282
112MP0003950_abnormal_plasma_membrane0.77322580
113MP0000627_abnormal_mammary_gland0.76017456
114MP0001346_abnormal_lacrimal_gland0.75356779
115MP0003868_abnormal_feces_composition0.74828406
116MP0004381_abnormal_hair_follicle0.73852892
117MP0002108_abnormal_muscle_morphology0.73569831
118MP0000371_diluted_coat_color0.73501323
119MP0008770_decreased_survivor_rate0.73284997
120MP0002111_abnormal_tail_morphology0.72250174
121MP0004133_heterotaxia0.72045058
122* MP0000313_abnormal_cell_death0.70459526
123MP0003385_abnormal_body_wall0.69464395
124MP0005310_abnormal_salivary_gland0.69216295
125MP0005621_abnormal_cell_physiology0.69037782
126MP0003755_abnormal_palate_morphology0.67304077
127MP0002019_abnormal_tumor_incidence0.67148827
128MP0005670_abnormal_white_adipose0.66959445
129MP0000579_abnormal_nail_morphology0.63389512
130* MP0001784_abnormal_fluid_regulation0.63122548
131MP0001177_atelectasis0.62058164
132MP0001216_abnormal_epidermal_layer0.59640074
133MP0001873_stomach_inflammation0.59118454
134MP0000462_abnormal_digestive_system0.58719897

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.85004838
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.71719944
3Abnormality of the lower motor neuron (HP:0002366)3.68609546
4Chromsome breakage (HP:0040012)3.66275186
5Astrocytoma (HP:0009592)3.58297224
6Abnormality of the astrocytes (HP:0100707)3.58297224
7Heterotopia (HP:0002282)3.19184120
8Volvulus (HP:0002580)3.12178608
9Glioma (HP:0009733)2.91617146
10Neoplasm of the oral cavity (HP:0100649)2.84138970
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.81818720
12Short 4th metacarpal (HP:0010044)2.81818720
13Nephroblastoma (Wilms tumor) (HP:0002667)2.74617134
14Deep philtrum (HP:0002002)2.70956153
15Acute myeloid leukemia (HP:0004808)2.66473579
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.66390383
17Medulloblastoma (HP:0002885)2.65338866
18Embryonal renal neoplasm (HP:0011794)2.56862930
19Increased nuchal translucency (HP:0010880)2.55804417
20Selective tooth agenesis (HP:0001592)2.53045937
21Biliary tract neoplasm (HP:0100574)2.49427061
22Abnormality of the labia minora (HP:0012880)2.47432481
23Renovascular hypertension (HP:0100817)2.46568604
24Shallow orbits (HP:0000586)2.42122989
25Cerebral aneurysm (HP:0004944)2.41048360
26Abnormality of chromosome stability (HP:0003220)2.37042316
27Truncal obesity (HP:0001956)2.35628739
28Deviation of the thumb (HP:0009603)2.34725114
29Proximal placement of thumb (HP:0009623)2.28940072
30Ankle contracture (HP:0006466)2.27911718
31Hyperacusis (HP:0010780)2.25948302
32Macroorchidism (HP:0000053)2.24148828
33Overlapping toe (HP:0001845)2.23393684
34Missing ribs (HP:0000921)2.22465359
35Neoplasm of striated muscle (HP:0009728)2.22237940
36Impulsivity (HP:0100710)2.20653210
37Insidious onset (HP:0003587)2.19690161
38Termporal pattern (HP:0011008)2.19690161
39Rhabdomyosarcoma (HP:0002859)2.17836249
40Sandal gap (HP:0001852)2.17544754
41Abnormality of the 4th metacarpal (HP:0010012)2.17183016
42Absent frontal sinuses (HP:0002688)2.17045316
43Prominent nose (HP:0000448)2.16210511
44Abnormality of the fingertips (HP:0001211)2.15082475
45Malignant gastrointestinal tract tumors (HP:0006749)2.14381056
46Gastrointestinal carcinoma (HP:0002672)2.14381056
47Long eyelashes (HP:0000527)2.13415601
48Vertebral arch anomaly (HP:0008438)2.12473015
49Relative macrocephaly (HP:0004482)2.12275739
50Curly hair (HP:0002212)2.11549113
51Transitional cell carcinoma of the bladder (HP:0006740)2.11267520
52Urethral obstruction (HP:0000796)2.11138322
53Hypopigmentation of the fundus (HP:0007894)2.11096062
54Leiomyosarcoma (HP:0100243)2.10683797
55Uterine leiomyosarcoma (HP:0002891)2.10683797
56Neonatal hypoglycemia (HP:0001998)2.08935598
57Abnormality of chromosome segregation (HP:0002916)2.07994429
58Skull defect (HP:0001362)2.07391878
59Short humerus (HP:0005792)2.06818029
60Dynein arm defect of respiratory motile cilia (HP:0012255)2.06406728
61Absent/shortened dynein arms (HP:0200106)2.06406728
62Supernumerary ribs (HP:0005815)2.05659786
63Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.04779250
64Thyroid carcinoma (HP:0002890)2.04575002
65Bowel diverticulosis (HP:0005222)2.03765055
66Papillary thyroid carcinoma (HP:0002895)2.03618717
67Hand muscle atrophy (HP:0009130)2.01187614
68Bladder neoplasm (HP:0009725)2.00727529
69Bladder carcinoma (HP:0002862)2.00727529
70Aplasia/Hypoplasia of the sternum (HP:0006714)2.00221892
71Obsessive-compulsive behavior (HP:0000722)1.99815997
72Trigonocephaly (HP:0000243)1.99256287
73Sparse lateral eyebrow (HP:0005338)1.99256139
74Pseudobulbar signs (HP:0002200)1.99194005
75Hypoplastic ischia (HP:0003175)1.98370754
76Asymmetry of the thorax (HP:0001555)1.96689178
77Overgrowth (HP:0001548)1.94812733
78Hypoplastic labia majora (HP:0000059)1.93966686
79Subacute progressive viral hepatitis (HP:0006572)1.93332868
80Elfin facies (HP:0004428)1.93068304
81Germ cell neoplasia (HP:0100728)1.91770390
82Upper limb amyotrophy (HP:0009129)1.90090641
83Distal upper limb amyotrophy (HP:0007149)1.90090641
84Cystic hygroma (HP:0000476)1.89507098
85Ectopic kidney (HP:0000086)1.88359646
86Cubitus valgus (HP:0002967)1.88207179
87Broad thumb (HP:0011304)1.88140536
88Ankyloglossia (HP:0010296)1.87867274
89Abnormality of the distal phalanx of the thumb (HP:0009617)1.87097053
90Protruding tongue (HP:0010808)1.86913633
91Narrow palate (HP:0000189)1.85082772
92Increased connective tissue (HP:0009025)1.84795555
93Low anterior hairline (HP:0000294)1.84636484
94Acute lymphatic leukemia (HP:0006721)1.84520248
95Colon cancer (HP:0003003)1.84007005
96Renal duplication (HP:0000075)1.82308626
97IgA deficiency (HP:0002720)1.82117249
98High pitched voice (HP:0001620)1.80601999
99Short chin (HP:0000331)1.80436493
100Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.80357031
101Aplasia/hypoplasia of the humerus (HP:0006507)1.79975950
102Fibroma (HP:0010614)1.78550057
103Fibrous tissue neoplasm (HP:0012316)1.78543432
104Dysmetric saccades (HP:0000641)1.77077176
105Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.77026118
106Abnormality of the diencephalon (HP:0010662)1.76970294
107Hepatoblastoma (HP:0002884)1.76717863
108Capillary hemangiomas (HP:0005306)1.76251896
109Viral hepatitis (HP:0006562)1.76004029
110Male infertility (HP:0003251)1.75865141
111Colitis (HP:0002583)1.75667361
112Upper motor neuron abnormality (HP:0002127)1.74090024
113Abnormality of the labia majora (HP:0012881)1.72927910
114Abnormality of the ischium (HP:0003174)1.72161926
115Protrusio acetabuli (HP:0003179)1.72036490
116Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.71957419
117Amyotrophic lateral sclerosis (HP:0007354)1.71399927
118Cortical dysplasia (HP:0002539)1.71291571
119Difficulty running (HP:0009046)1.71243918
120Abnormality of the epiphyses of the hand (HP:0005924)1.71240283
121Hyporeflexia of lower limbs (HP:0002600)1.71113294
122Neoplasm of the small intestine (HP:0100833)1.70853189
123Broad phalanges of the hand (HP:0009768)1.69991907
124Cutis marmorata (HP:0000965)1.69962808
125Resting tremor (HP:0002322)1.69268200
126Supernumerary bones of the axial skeleton (HP:0009144)1.69014764
127Rectal prolapse (HP:0002035)1.68106120
128Metaphyseal cupping (HP:0003021)1.67636525
129Syringomyelia (HP:0003396)1.67381197
130Spinal cord lesions (HP:0100561)1.67381197
131Thick eyebrow (HP:0000574)1.67034760
132Short phalanx of the thumb (HP:0009660)1.66408948
133Genu recurvatum (HP:0002816)1.64768025
134Birth length less than 3rd percentile (HP:0003561)1.64549364
135Smooth philtrum (HP:0000319)1.64489797
136Basal cell carcinoma (HP:0002671)1.63835557
137Embryonal neoplasm (HP:0002898)1.63530424
138Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.62474135
139Anal stenosis (HP:0002025)1.61827536
140Advanced eruption of teeth (HP:0006288)1.61801870
141Enlarged penis (HP:0000040)1.61700247
142Cafe-au-lait spot (HP:0000957)1.61062304
143Persistence of primary teeth (HP:0006335)1.60989980
144Aplasia/Hypoplasia of the uvula (HP:0010293)1.60978573
145Short ribs (HP:0000773)1.60851238
146Overriding aorta (HP:0002623)1.60812396
147Myelodysplasia (HP:0002863)1.60689243
148Wide nose (HP:0000445)1.60119546
149Abnormality of the carotid arteries (HP:0005344)1.60072918
150Bladder diverticulum (HP:0000015)1.59575229
151Broad palm (HP:0001169)1.58248267
152Radioulnar synostosis (HP:0002974)1.57764733
153Aneurysm (HP:0002617)1.57627477
154Fair hair (HP:0002286)1.57535648
155Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.57152304
156Short 1st metacarpal (HP:0010034)1.57152304
157Flat acetabular roof (HP:0003180)1.57008018
158Broad finger (HP:0001500)1.55735305

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.13201415
2CDC73.21054290
3PDK43.08469813
4PDK33.08469813
5LATS12.86138933
6NEK22.57976381
7EEF2K2.28648894
8PNCK2.25924099
9PKN22.23365445
10ICK2.16144959
11BRD42.06573551
12CAMK1D1.89545575
13TTN1.85854156
14CAMK1G1.81585692
15PDK21.79104150
16TTK1.75603180
17SMG11.75074991
18EPHA21.72860563
19NEK11.72678283
20MKNK21.72306024
21TRIB31.71488768
22RIPK11.70401107
23PRKD31.67999559
24MTOR1.65512509
25PDGFRA1.63895102
26FGFR41.59270519
27STK31.54685284
28SCYL21.51769681
29MAP3K101.49645356
30WEE11.48789623
31ALK1.35440081
32CDK61.34980074
33EIF2AK31.31363596
34CHEK11.31039215
35ATR1.25668874
36MKNK11.22324781
37TRPM71.21701311
38TYRO31.20982051
39CDK41.14996191
40PRPF4B1.11749407
41MAP3K131.11630021
42PASK1.10790856
43LATS21.10433295
44RPS6KB21.08919636
45NEK91.08660474
46PTK61.07498237
47SGK21.07479007
48TAF11.07373885
49FGFR11.04238678
50CHEK21.03946211
51* ATM1.03869158
52YES10.98547703
53DDR20.97409769
54NEK60.96253925
55STK380.95795472
56PLK10.95201964
57FGFR20.93578556
58PDGFRB0.91017412
59BMX0.88841585
60NLK0.87923169
61MAP3K140.86220615
62WNK10.86069645
63PAK20.85864925
64CDK20.84737290
65CSNK1D0.84626409
66CDK70.83388358
67SIK10.80603605
68AURKB0.80293115
69STK38L0.76067879
70KSR20.75791854
71MET0.73793258
72CDK90.73099017
73PAK40.71571103
74PLK30.71540569
75FGFR30.71094171
76TESK10.69791848
77MELK0.66673784
78PRKDC0.66519617
79CDK10.66165430
80STK240.66008218
81MAP3K80.65970436
82MAP3K20.64386368
83SRPK10.63411614
84PLK40.62795166
85TSSK60.62611983
86DMPK0.62070228
87TNIK0.61224228
88STK100.61131022
89MAP3K60.60762194
90MAP3K70.60193402
91MAP3K90.60110052
92RAF10.59832970
93FLT30.58283632
94PBK0.58223810
95PTK20.58121583
96STK40.57804743
97CSNK1E0.57548494
98RET0.56264458
99SGK30.52651251
100EIF2AK10.51939610
101BRSK20.51638683
102MAPK140.50898243
103PIK3CA0.49983808
104GSK3B0.48956292
105CHUK0.48196471
106FRK0.46633909
107MAPK10.46207605
108CDC42BPA0.46172982
109TEC0.46129663
110PTK2B0.46083313
111FER0.45888831
112MAPK100.45568516
113PRKAA10.45044822
114PAK60.44992616
115CLK10.44034791
116AKT30.42145595
117SGK4940.42136008
118SGK2230.42136008
119SGK10.41008505
120LMTK20.40744746
121DYRK1B0.40718979
122TGFBR10.39246076
123MAPK80.39030337
124MST1R0.38962215
125AKT10.38417596
126RPS6KB10.37770236
127JAK10.37744880
128MARK20.37437311
129KSR10.36874263
130AKT20.35916439
131PIM10.34073483
132ACVR1B0.31843726
133TAOK10.31688314
134MAP3K40.31126693
135RPS6KA30.30634427
136STK110.29962827

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA transport_Homo sapiens_hsa030132.33462598
2mRNA surveillance pathway_Homo sapiens_hsa030152.21422655
3Lysine degradation_Homo sapiens_hsa003102.12126587
4Cell cycle_Homo sapiens_hsa041101.86933832
5One carbon pool by folate_Homo sapiens_hsa006701.84172086
6mTOR signaling pathway_Homo sapiens_hsa041501.81582475
7Adherens junction_Homo sapiens_hsa045201.80243133
8Dorso-ventral axis formation_Homo sapiens_hsa043201.80053023
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.79158324
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63921911
11MicroRNAs in cancer_Homo sapiens_hsa052061.63085745
12* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.61464251
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.60731210
14Nitrogen metabolism_Homo sapiens_hsa009101.59898288
15B cell receptor signaling pathway_Homo sapiens_hsa046621.58120677
16Central carbon metabolism in cancer_Homo sapiens_hsa052301.56414321
17Selenocompound metabolism_Homo sapiens_hsa004501.55919859
18Mismatch repair_Homo sapiens_hsa034301.53670406
19Fanconi anemia pathway_Homo sapiens_hsa034601.52439353
20Thyroid hormone signaling pathway_Homo sapiens_hsa049191.48069400
21Basal cell carcinoma_Homo sapiens_hsa052171.46237648
22Oocyte meiosis_Homo sapiens_hsa041141.41879163
23Hippo signaling pathway_Homo sapiens_hsa043901.37511739
24Small cell lung cancer_Homo sapiens_hsa052221.34753841
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.34281470
26Systemic lupus erythematosus_Homo sapiens_hsa053221.33390146
27Viral carcinogenesis_Homo sapiens_hsa052031.32475760
28Glucagon signaling pathway_Homo sapiens_hsa049221.30773834
29Fatty acid biosynthesis_Homo sapiens_hsa000611.28854451
30Prolactin signaling pathway_Homo sapiens_hsa049171.28077774
31Proteoglycans in cancer_Homo sapiens_hsa052051.24687220
32Spliceosome_Homo sapiens_hsa030401.19550446
33Choline metabolism in cancer_Homo sapiens_hsa052311.19539767
34Chronic myeloid leukemia_Homo sapiens_hsa052201.19537703
35Endometrial cancer_Homo sapiens_hsa052131.16978823
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.16773249
37Focal adhesion_Homo sapiens_hsa045101.15894279
38Notch signaling pathway_Homo sapiens_hsa043301.15561292
39TGF-beta signaling pathway_Homo sapiens_hsa043501.13050744
40DNA replication_Homo sapiens_hsa030301.12025126
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08900548
42ECM-receptor interaction_Homo sapiens_hsa045121.08324434
43AMPK signaling pathway_Homo sapiens_hsa041521.06610694
44Hedgehog signaling pathway_Homo sapiens_hsa043401.06147299
45Hepatitis B_Homo sapiens_hsa051611.04337044
46Type II diabetes mellitus_Homo sapiens_hsa049301.03805201
47Colorectal cancer_Homo sapiens_hsa052101.03175946
48Tight junction_Homo sapiens_hsa045301.03134831
49p53 signaling pathway_Homo sapiens_hsa041151.02616528
50Insulin resistance_Homo sapiens_hsa049311.01502205
51HTLV-I infection_Homo sapiens_hsa051661.01387124
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00092659
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.99901943
54Prostate cancer_Homo sapiens_hsa052150.95401114
55Non-homologous end-joining_Homo sapiens_hsa034500.95025298
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93482985
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92193268
58Estrogen signaling pathway_Homo sapiens_hsa049150.91440524
59T cell receptor signaling pathway_Homo sapiens_hsa046600.90017195
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89931561
61Viral myocarditis_Homo sapiens_hsa054160.88559212
62RNA degradation_Homo sapiens_hsa030180.87187012
63Glioma_Homo sapiens_hsa052140.87060287
64Wnt signaling pathway_Homo sapiens_hsa043100.85066860
65Insulin signaling pathway_Homo sapiens_hsa049100.83992657
66Bladder cancer_Homo sapiens_hsa052190.83615208
67Biosynthesis of amino acids_Homo sapiens_hsa012300.81953411
68Measles_Homo sapiens_hsa051620.81903443
69Non-small cell lung cancer_Homo sapiens_hsa052230.81808124
70Thyroid cancer_Homo sapiens_hsa052160.80880682
71Hepatitis C_Homo sapiens_hsa051600.80486494
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.80204981
73Basal transcription factors_Homo sapiens_hsa030220.78777475
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77848220
75Nucleotide excision repair_Homo sapiens_hsa034200.77161326
76Influenza A_Homo sapiens_hsa051640.75672310
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73979018
78Pathways in cancer_Homo sapiens_hsa052000.73792343
79Alcoholism_Homo sapiens_hsa050340.73340662
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72426541
81Long-term potentiation_Homo sapiens_hsa047200.72061662
82Antigen processing and presentation_Homo sapiens_hsa046120.70682155
83HIF-1 signaling pathway_Homo sapiens_hsa040660.70158046
84FoxO signaling pathway_Homo sapiens_hsa040680.69711740
85GnRH signaling pathway_Homo sapiens_hsa049120.68475784
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68474575
87Inositol phosphate metabolism_Homo sapiens_hsa005620.66096250
88Platelet activation_Homo sapiens_hsa046110.65041464
89Epstein-Barr virus infection_Homo sapiens_hsa051690.64766388
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64437406
91Renal cell carcinoma_Homo sapiens_hsa052110.63760871
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63755020
93Herpes simplex infection_Homo sapiens_hsa051680.63526436
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62661087
95Dilated cardiomyopathy_Homo sapiens_hsa054140.62334987
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.61680814
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61240140
98Amoebiasis_Homo sapiens_hsa051460.61085583
99Pancreatic cancer_Homo sapiens_hsa052120.59770567
100Homologous recombination_Homo sapiens_hsa034400.59692598
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.58806385
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.58311851
103Circadian rhythm_Homo sapiens_hsa047100.58124798
104Apoptosis_Homo sapiens_hsa042100.57944954
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.57706515
106Long-term depression_Homo sapiens_hsa047300.56766942
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56557844
108VEGF signaling pathway_Homo sapiens_hsa043700.55810179
109Melanoma_Homo sapiens_hsa052180.55368971
110Toxoplasmosis_Homo sapiens_hsa051450.54753044
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.54695163
112Acute myeloid leukemia_Homo sapiens_hsa052210.53752314
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52097704
114Carbon metabolism_Homo sapiens_hsa012000.51864847
115ErbB signaling pathway_Homo sapiens_hsa040120.51848577
116MAPK signaling pathway_Homo sapiens_hsa040100.51275895
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50321570
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49409253
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48775610
120Base excision repair_Homo sapiens_hsa034100.47843885
121Protein digestion and absorption_Homo sapiens_hsa049740.46952151
122Rap1 signaling pathway_Homo sapiens_hsa040150.45630397
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45360699

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