UBR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1monoubiquitinated protein deubiquitination (GO:0035520)5.95409917
2nuclear pore complex assembly (GO:0051292)5.78586795
3nuclear pore organization (GO:0006999)5.62463615
4interkinetic nuclear migration (GO:0022027)5.50011986
5mitotic sister chromatid cohesion (GO:0007064)4.64227310
6establishment of protein localization to Golgi (GO:0072600)4.23470149
7phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.17803905
8neuron cell-cell adhesion (GO:0007158)4.14965952
9pore complex assembly (GO:0046931)4.08553375
10presynaptic membrane assembly (GO:0097105)4.06999308
11presynaptic membrane organization (GO:0097090)3.83989843
12protein targeting to Golgi (GO:0000042)3.81918006
13neural tube formation (GO:0001841)3.71204614
14axon ensheathment in central nervous system (GO:0032291)3.70401745
15central nervous system myelination (GO:0022010)3.70401745
16nucleus localization (GO:0051647)3.63104384
17retrograde transport, vesicle recycling within Golgi (GO:0000301)3.61812057
18regulation of RNA export from nucleus (GO:0046831)3.60514744
19negative regulation of neurotransmitter secretion (GO:0046929)3.53138509
20Golgi to endosome transport (GO:0006895)3.44393796
21negative regulation of neurotransmitter transport (GO:0051589)3.44287754
22axonal fasciculation (GO:0007413)3.35422015
23regulation of transforming growth factor beta2 production (GO:0032909)3.33544645
24neuron recognition (GO:0008038)3.30420912
25vocalization behavior (GO:0071625)3.28355687
26pericardium development (GO:0060039)3.24213143
27negative regulation of translation, ncRNA-mediated (GO:0040033)3.22360090
28regulation of translation, ncRNA-mediated (GO:0045974)3.22360090
29negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.22360090
30L-amino acid import (GO:0043092)3.22033885
31interleukin-6-mediated signaling pathway (GO:0070102)3.21698166
32transmission of nerve impulse (GO:0019226)3.19144186
33negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.18262111
34regulation of short-term neuronal synaptic plasticity (GO:0048172)3.17806185
35cyclic nucleotide catabolic process (GO:0009214)3.16910210
36microtubule anchoring (GO:0034453)3.13883793
37positive regulation of cardiac muscle cell differentiation (GO:2000727)3.12206247
38startle response (GO:0001964)3.11525331
39cerebellar Purkinje cell differentiation (GO:0021702)3.10528280
40protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)3.06681893
41cAMP catabolic process (GO:0006198)3.05111737
42retina layer formation (GO:0010842)3.01686470
43gamma-aminobutyric acid signaling pathway (GO:0007214)3.00858620
44mechanosensory behavior (GO:0007638)3.00048404
45protein localization to synapse (GO:0035418)2.99879906
46positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.97306066
47ionotropic glutamate receptor signaling pathway (GO:0035235)2.96043134
48protein K48-linked deubiquitination (GO:0071108)2.95156760
49keratinocyte development (GO:0003334)2.93371764
50neuronal ion channel clustering (GO:0045161)2.92394794
51auditory behavior (GO:0031223)2.92208981
52negative regulation of potassium ion transmembrane transport (GO:1901380)2.90770364
53negative regulation of DNA repair (GO:0045738)2.89424827
54cellular response to ethanol (GO:0071361)2.89130282
55histone H3-K4 trimethylation (GO:0080182)2.87294158
56protein K11-linked deubiquitination (GO:0035871)2.86729735
57cerebral cortex radially oriented cell migration (GO:0021799)2.86728045
58locomotory exploration behavior (GO:0035641)2.86163608
59glutamate receptor signaling pathway (GO:0007215)2.84313622
60sister chromatid cohesion (GO:0007062)2.83821311
61central nervous system projection neuron axonogenesis (GO:0021952)2.83419964
62protein targeting to lysosome (GO:0006622)2.82179351
63establishment of protein localization to vacuole (GO:0072666)2.82179351
64protein targeting to vacuole (GO:0006623)2.82179351
65iron ion import (GO:0097286)2.81142459
66positive regulation of developmental pigmentation (GO:0048087)2.80010885
67protein prenylation (GO:0018342)2.79535690
68prenylation (GO:0097354)2.79535690
69regulation of sarcomere organization (GO:0060297)2.79403395
70regulation of relaxation of muscle (GO:1901077)2.78006735
71regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.77804287
72regulation of establishment of cell polarity (GO:2000114)2.77264198
73regulation of protein polyubiquitination (GO:1902914)2.74713477
74dendrite morphogenesis (GO:0048813)2.73420659
75peptidyl-lysine trimethylation (GO:0018023)2.73264013
76muscle atrophy (GO:0014889)2.73233022
77regulation of pigment cell differentiation (GO:0050932)2.70965466
78regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.70281292
79synaptic transmission, glutamatergic (GO:0035249)2.68767532
80early endosome to late endosome transport (GO:0045022)2.67372623
81ER overload response (GO:0006983)2.67319877
82skeletal muscle adaptation (GO:0043501)2.67187114
83cell wall macromolecule catabolic process (GO:0016998)2.66853939
84myelin assembly (GO:0032288)2.66400981
85long-chain fatty acid biosynthetic process (GO:0042759)2.65298736
86regulation of skeletal muscle cell differentiation (GO:2001014)2.65221037
87striated muscle atrophy (GO:0014891)2.65161012
88negative regulation of synaptic transmission, GABAergic (GO:0032229)2.64928499
89regulation of protein glycosylation (GO:0060049)2.63842849
90tyrosine phosphorylation of STAT protein (GO:0007260)2.63368487
91regulation of nucleobase-containing compound transport (GO:0032239)2.61478996
92eye photoreceptor cell differentiation (GO:0001754)2.61106638
93photoreceptor cell differentiation (GO:0046530)2.61106638
94regulation of DNA endoreduplication (GO:0032875)2.60553140
95asymmetric protein localization (GO:0008105)2.59966805
96neuron-neuron synaptic transmission (GO:0007270)2.59029215
97protein localization to Golgi apparatus (GO:0034067)2.57903335
98regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.57422158
99establishment of nucleus localization (GO:0040023)2.56596483
100pre-miRNA processing (GO:0031054)2.56284540
101establishment of mitochondrion localization (GO:0051654)2.54006415
102Notch signaling involved in heart development (GO:0061314)2.53620764
103G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.52687191
104myofibril assembly (GO:0030239)2.52627169
105positive regulation of mitotic sister chromatid separation (GO:1901970)2.52391776
106positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.52391776
107positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.52391776
108regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.52331772
109intra-Golgi vesicle-mediated transport (GO:0006891)2.52290948
110regulation of feeding behavior (GO:0060259)2.52251833
111regulation of meiosis I (GO:0060631)2.51616349
112histone mRNA catabolic process (GO:0071044)2.51448264
113myelination (GO:0042552)2.51140509
114regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.50799828
115positive regulation of synapse assembly (GO:0051965)2.50394498
116central nervous system neuron axonogenesis (GO:0021955)2.50322348
117histone H3-K36 demethylation (GO:0070544)2.49860240
118macroautophagy (GO:0016236)2.49731079
119protein deubiquitination (GO:0016579)2.49650964
120synapse assembly (GO:0007416)2.49269356
121regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.48940170
122gamma-aminobutyric acid transport (GO:0015812)2.48536050
123synaptic vesicle maturation (GO:0016188)2.47944699
124nucleus organization (GO:0006997)2.47929796
125mRNA splice site selection (GO:0006376)2.47556011
126positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.46214802
127dendritic spine morphogenesis (GO:0060997)2.45561268
128regulation of synaptic transmission, GABAergic (GO:0032228)2.45146613
129lipid translocation (GO:0034204)2.44939353
130phospholipid translocation (GO:0045332)2.44939353
131detection of calcium ion (GO:0005513)2.44248275
132glycoprotein catabolic process (GO:0006516)2.43399135
133regulation of glutamate receptor signaling pathway (GO:1900449)2.42952531
134postsynaptic membrane organization (GO:0001941)2.42628078
135righting reflex (GO:0060013)2.41650696
136regulation of centriole replication (GO:0046599)2.41357101
137secondary heart field specification (GO:0003139)2.40811067
138heart field specification (GO:0003128)2.40811067
139amino acid import (GO:0043090)2.39639040
140synaptic vesicle exocytosis (GO:0016079)2.39503414
141axon ensheathment (GO:0008366)2.39369616
142ensheathment of neurons (GO:0007272)2.39369616
143regulation of cell communication by electrical coupling (GO:0010649)2.38509694
144regulation of excitatory postsynaptic membrane potential (GO:0060079)2.38422964
145vesicle transport along microtubule (GO:0047496)2.38182880
146N-terminal protein amino acid acetylation (GO:0006474)2.38091110
147peptidyl-threonine phosphorylation (GO:0018107)2.37570595
148negative regulation of axon extension (GO:0030517)2.37007019
149negative regulation of meiosis (GO:0045835)2.36320861
150cytoplasmic mRNA processing body assembly (GO:0033962)2.36250412
151positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.35517873
152regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.35246211
153regulation of synapse assembly (GO:0051963)2.35083235
154regulation of dendritic spine morphogenesis (GO:0061001)2.35069488
155peptidyl-threonine modification (GO:0018210)2.34863234
156peptidyl-lysine methylation (GO:0018022)2.34035483
157mRNA modification (GO:0016556)2.33796264
158protein K63-linked deubiquitination (GO:0070536)2.33170815
159interferon-gamma production (GO:0032609)2.32842026
160cardiac myofibril assembly (GO:0055003)2.32507343
161regulation of respiratory system process (GO:0044065)2.32152961
162synapse organization (GO:0050808)2.32043705
163positive regulation of dendritic spine morphogenesis (GO:0061003)2.31896443
164positive regulation of cardiac muscle hypertrophy (GO:0010613)2.31803244
165positive regulation of muscle hypertrophy (GO:0014742)2.31803244
166limb bud formation (GO:0060174)2.31724459
167actin-mediated cell contraction (GO:0070252)2.31644299
168definitive hemopoiesis (GO:0060216)2.31380226
169regulation of respiratory gaseous exchange (GO:0043576)2.30928539
170peripheral nervous system axon ensheathment (GO:0032292)2.30661964
171myelination in peripheral nervous system (GO:0022011)2.30661964
172cell differentiation in hindbrain (GO:0021533)2.30202169
173neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.30060226
174negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.30035294
175response to auditory stimulus (GO:0010996)2.29466642
176glomerulus development (GO:0032835)2.28737038
177developmental pigmentation (GO:0048066)2.28376010
178positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.28299778
179regulation of axon guidance (GO:1902667)2.26584256
180regulation of axon extension involved in axon guidance (GO:0048841)2.26281600
181neuronal action potential propagation (GO:0019227)2.25426694
182cAMP metabolic process (GO:0046058)2.25118100
183regulation of synaptic vesicle exocytosis (GO:2000300)2.24935742
184mesenchymal cell differentiation involved in kidney development (GO:0072161)2.24879120
185mesenchymal cell differentiation involved in renal system development (GO:2001012)2.24879120
186regulation of postsynaptic membrane potential (GO:0060078)2.24661609
187import into cell (GO:0098657)2.24655951
188nerve growth factor signaling pathway (GO:0038180)2.23820032
189regulation of long-term neuronal synaptic plasticity (GO:0048169)2.22969248
190regulation of somitogenesis (GO:0014807)2.22755550
191regulation of synaptic transmission, glutamatergic (GO:0051966)2.22630106

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.04338026
2EZH2_22144423_ChIP-Seq_EOC_Human3.38473108
3SMAD_19615063_ChIP-ChIP_OVARY_Human2.72802539
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.63278290
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.56002008
6TAF15_26573619_Chip-Seq_HEK293_Human2.51249206
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31543599
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21943327
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21795824
10AR_21572438_ChIP-Seq_LNCaP_Human2.16721624
11* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.13837827
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.13402508
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06700236
14PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.05917656
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.00315472
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.98271151
17P300_19829295_ChIP-Seq_ESCs_Human1.97298144
18FUS_26573619_Chip-Seq_HEK293_Human1.92010148
19OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.86188902
20SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.84095092
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83686307
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.82331343
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.82288977
24* SMAD4_21799915_ChIP-Seq_A2780_Human1.81433886
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80708883
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.79281227
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78690690
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.74445177
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73043158
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.72932519
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.71890217
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.71890217
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.71125686
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.68762129
35TP53_16413492_ChIP-PET_HCT116_Human1.68110457
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67418240
37STAT3_23295773_ChIP-Seq_U87_Human1.67042180
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66971407
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.66734383
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.66636562
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.62624764
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.61540155
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.61129105
44EWS_26573619_Chip-Seq_HEK293_Human1.61095379
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.61024541
46IGF1R_20145208_ChIP-Seq_DFB_Human1.58591855
47DROSHA_22980978_ChIP-Seq_HELA_Human1.58582624
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.56110562
49ER_23166858_ChIP-Seq_MCF-7_Human1.56004266
50VDR_22108803_ChIP-Seq_LS180_Human1.53894218
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53039823
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50704274
53TCF4_23295773_ChIP-Seq_U87_Human1.48461780
54* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46240701
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44065613
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.42304203
57FOXM1_26456572_ChIP-Seq_MCF-7_Human1.42057324
58AHR_22903824_ChIP-Seq_MCF-7_Human1.41912122
59SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41425732
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.41413703
61* NANOG_18555785_Chip-Seq_ESCs_Mouse1.40784717
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40259924
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40259924
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.40028007
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.38957374
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.38936793
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37776514
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35724054
69CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.34965371
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34289957
71TP53_18474530_ChIP-ChIP_U2OS_Human1.31316299
72RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.30539951
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30528497
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29545455
75AR_25329375_ChIP-Seq_VCAP_Human1.28661993
76ZNF274_21170338_ChIP-Seq_K562_Hela1.28523513
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.28266158
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27759640
79REST_21632747_ChIP-Seq_MESCs_Mouse1.27674159
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27316780
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26794133
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26592444
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.26283354
84EZH2_27294783_Chip-Seq_ESCs_Mouse1.26042263
85RUNX2_22187159_ChIP-Seq_PCA_Human1.25732194
86* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25429398
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25170628
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.23782157
89* E2F1_18555785_Chip-Seq_ESCs_Mouse1.21674584
90SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21310896
91PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21263456
92* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21127687
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20527964
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19665866
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19632734
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19229817
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19229817
98FLI1_21867929_ChIP-Seq_TH2_Mouse1.18350299
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17469886
100* CMYC_18555785_Chip-Seq_ESCs_Mouse1.17339802
101CRX_20693478_ChIP-Seq_RETINA_Mouse1.17318924
102YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16964335
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16527375
104EP300_21415370_ChIP-Seq_HL-1_Mouse1.15752660
105BCAT_22108803_ChIP-Seq_LS180_Human1.15354250
106CDX2_22108803_ChIP-Seq_LS180_Human1.15210969
107CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15089174
108OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14919111
109HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14238373
110TCF4_18268006_ChIP-ChIP_LS174T_Human1.13851526
111CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13760022
112GATA1_22025678_ChIP-Seq_K562_Human1.13430524
113PRDM14_20953172_ChIP-Seq_ESCs_Human1.12969974
114BRD4_25478319_ChIP-Seq_HGPS_Human1.12194707
115* P300_18555785_Chip-Seq_ESCs_Mouse1.12037699
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09884731
117P53_22387025_ChIP-Seq_ESCs_Mouse1.09817743
118TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09193947
119NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08007747
120RXR_22108803_ChIP-Seq_LS180_Human1.07893461
121IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07393070
122CBP_20019798_ChIP-Seq_JUKART_Human1.07393070
123RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06264751
124EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05357586
125* OCT4_18555785_Chip-Seq_ESCs_Mouse1.05157987
126* STAT3_18555785_Chip-Seq_ESCs_Mouse1.04813883
127* SOX2_18555785_Chip-Seq_ESCs_Mouse1.02988136
128SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01563380
129TCF4_22108803_ChIP-Seq_LS180_Human1.01055334
130* NMYC_18555785_Chip-Seq_ESCs_Mouse1.00105243

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.78002838
2MP0004084_abnormal_cardiac_muscle3.66555029
3MP0002837_dystrophic_cardiac_calcinosis3.50579986
4MP0005409_darkened_coat_color3.45666816
5MP0003880_abnormal_central_pattern3.44885641
6MP0003787_abnormal_imprinting3.19653273
7MP0004859_abnormal_synaptic_plasticity3.13616525
8MP0005171_absent_coat_pigmentation2.99130327
9MP0001188_hyperpigmentation2.84077720
10MP0000569_abnormal_digit_pigmentation2.60760134
11MP0003635_abnormal_synaptic_transmissio2.56079069
12MP0004036_abnormal_muscle_relaxation2.53372204
13MP0004270_analgesia2.51876909
14MP0004215_abnormal_myocardial_fiber2.42432191
15MP0009745_abnormal_behavioral_response2.37443569
16MP0010352_gastrointestinal_tract_polyps2.29037140
17MP0001486_abnormal_startle_reflex2.19850016
18MP0000778_abnormal_nervous_system2.14806782
19MP0002064_seizures2.08468772
20MP0002272_abnormal_nervous_system2.01038025
21MP0005174_abnormal_tail_pigmentation1.99460108
22* MP0002063_abnormal_learning/memory/cond1.96473512
23MP0001968_abnormal_touch/_nociception1.94095273
24* MP0002572_abnormal_emotion/affect_behav1.88590914
25MP0002009_preneoplasia1.84506986
26MP0000920_abnormal_myelination1.84097461
27MP0000566_synostosis1.80032357
28MP0008775_abnormal_heart_ventricle1.78097575
29MP0003221_abnormal_cardiomyocyte_apopto1.76349147
30MP0005646_abnormal_pituitary_gland1.74940211
31MP0009046_muscle_twitch1.73502777
32MP0002735_abnormal_chemical_nociception1.72494857
33MP0001177_atelectasis1.71844415
34MP0003941_abnormal_skin_development1.66405828
35MP0003656_abnormal_erythrocyte_physiolo1.66018890
36MP0000015_abnormal_ear_pigmentation1.63123154
37MP0008569_lethality_at_weaning1.62176422
38MP0003646_muscle_fatigue1.59912457
39MP0002067_abnormal_sensory_capabilities1.59527745
40MP0002734_abnormal_mechanical_nocicepti1.57534913
41MP0002822_catalepsy1.57412118
42MP0004742_abnormal_vestibular_system1.55742175
43MP0005551_abnormal_eye_electrophysiolog1.53019673
44MP0005423_abnormal_somatic_nervous1.52672636
45MP0004924_abnormal_behavior1.49571041
46MP0005386_behavior/neurological_phenoty1.49571041
47MP0002557_abnormal_social/conspecific_i1.48713751
48MP0009697_abnormal_copulation1.46923737
49MP0005187_abnormal_penis_morphology1.45974101
50MP0000749_muscle_degeneration1.45133607
51MP0000427_abnormal_hair_cycle1.44383281
52MP0002736_abnormal_nociception_after1.42687317
53MP0002396_abnormal_hematopoietic_system1.40178570
54MP0000631_abnormal_neuroendocrine_gland1.36793853
55MP0000371_diluted_coat_color1.36583050
56MP0002006_tumorigenesis1.36208685
57MP0001502_abnormal_circadian_rhythm1.35858972
58MP0003121_genomic_imprinting1.35444488
59MP0001501_abnormal_sleep_pattern1.34624252
60MP0005503_abnormal_tendon_morphology1.33613265
61MP0004145_abnormal_muscle_electrophysio1.33394934
62MP0010678_abnormal_skin_adnexa1.33166599
63MP0010307_abnormal_tumor_latency1.31349488
64MP0002184_abnormal_innervation1.31167588
65MP0010234_abnormal_vibrissa_follicle1.30749804
66MP0003943_abnormal_hepatobiliary_system1.29253917
67MP0001529_abnormal_vocalization1.28858133
68MP0005645_abnormal_hypothalamus_physiol1.28040972
69MP0001440_abnormal_grooming_behavior1.27880212
70MP0003632_abnormal_nervous_system1.25160037
71MP0001879_abnormal_lymphatic_vessel1.23547978
72MP0005275_abnormal_skin_tensile1.23501481
73MP0006138_congestive_heart_failure1.22870177
74MP0002168_other_aberrant_phenotype1.22535225
75MP0002938_white_spotting1.22477330
76MP0002088_abnormal_embryonic_growth/wei1.22033668
77MP0000955_abnormal_spinal_cord1.21074753
78MP0006054_spinal_hemorrhage1.20188320
79MP0003122_maternal_imprinting1.20165438
80MP0004134_abnormal_chest_morphology1.20150873
81MP0000383_abnormal_hair_follicle1.19667928
82MP0004233_abnormal_muscle_weight1.17434710
83MP0008438_abnormal_cutaneous_collagen1.17133134
84* MP0002882_abnormal_neuron_morphology1.16551097
85MP0004811_abnormal_neuron_physiology1.15076641
86MP0003631_nervous_system_phenotype1.14692151
87MP0009780_abnormal_chondrocyte_physiolo1.14622155
88MP0003633_abnormal_nervous_system1.14430367
89MP0003984_embryonic_growth_retardation1.13301428
90MP0001905_abnormal_dopamine_level1.12831703
91MP0004885_abnormal_endolymph1.11650481
92MP0003690_abnormal_glial_cell1.11486544
93MP0003136_yellow_coat_color1.11371753
94MP0004484_altered_response_of1.09747621
95MP0002166_altered_tumor_susceptibility1.09489065
96MP0005310_abnormal_salivary_gland1.08077694
97MP0002108_abnormal_muscle_morphology1.07855978
98MP0006276_abnormal_autonomic_nervous1.06420345
99MP0010368_abnormal_lymphatic_system1.06417181
100MP0005620_abnormal_muscle_contractility1.06357123
101MP0001984_abnormal_olfaction1.06046822
102MP0001661_extended_life_span1.05540801
103MP0000751_myopathy1.03889575
104MP0002733_abnormal_thermal_nociception1.02184083
105MP0003828_pulmonary_edema1.01111136
106MP0006072_abnormal_retinal_apoptosis1.00955428
107MP0005380_embryogenesis_phenotype1.00308144
108MP0001672_abnormal_embryogenesis/_devel1.00308144
109MP0002084_abnormal_developmental_patter0.99888110
110MP0001970_abnormal_pain_threshold0.99824318
111* MP0002066_abnormal_motor_capabilities/c0.99286096
112MP0009703_decreased_birth_body0.99134914
113MP0010094_abnormal_chromosome_stability0.98835207
114MP0002972_abnormal_cardiac_muscle0.98685079
115MP0001299_abnormal_eye_distance/0.98159105
116* MP0002152_abnormal_brain_morphology0.98072030
117MP0005623_abnormal_meninges_morphology0.97498469
118MP0004808_abnormal_hematopoietic_stem0.95367864
119MP0000516_abnormal_urinary_system0.95179479
120MP0005367_renal/urinary_system_phenotyp0.95179479
121MP0002177_abnormal_outer_ear0.95010337
122MP0002106_abnormal_muscle_physiology0.94959582
123MP0005395_other_phenotype0.94040507
124MP0004087_abnormal_muscle_fiber0.93999168
125MP0002127_abnormal_cardiovascular_syste0.93795073
126MP0002332_abnormal_exercise_endurance0.92784249
127MP0008877_abnormal_DNA_methylation0.92000759
128MP0004272_abnormal_basement_membrane0.91748968
129MP0003045_fibrosis0.90633129
130MP0005253_abnormal_eye_physiology0.87976412
131MP0004142_abnormal_muscle_tone0.87204180
132* MP0002086_abnormal_extraembryonic_tissu0.86774377
133MP0002229_neurodegeneration0.86394833
134MP0003950_abnormal_plasma_membrane0.86247772
135MP0002269_muscular_atrophy0.86170736
136MP0004130_abnormal_muscle_cell0.86152644
137MP0006292_abnormal_olfactory_placode0.85706955
138MP0008058_abnormal_DNA_repair0.85626539
139MP0001963_abnormal_hearing_physiology0.85220326
140MP0005266_abnormal_metabolism0.85176854
141MP0000013_abnormal_adipose_tissue0.84989974
142MP0003634_abnormal_glial_cell0.84331731
143MP0001191_abnormal_skin_condition0.82672665
144* MP0001784_abnormal_fluid_regulation0.80309959
145MP0000372_irregular_coat_pigmentation0.79113810
146MP0002752_abnormal_somatic_nervous0.78723109
147* MP0000266_abnormal_heart_morphology0.77728675
148MP0003890_abnormal_embryonic-extraembry0.76561946
149MP0004085_abnormal_heartbeat0.76294240
150MP0005076_abnormal_cell_differentiation0.76277897
151MP0000733_abnormal_muscle_development0.76203314
152MP0003566_abnormal_cell_adhesion0.75786791
153MP0003935_abnormal_craniofacial_develop0.75543492
154MP0003786_premature_aging0.75209590
155MP0002075_abnormal_coat/hair_pigmentati0.74609123
156MP0000003_abnormal_adipose_tissue0.73752919
157MP0004147_increased_porphyrin_level0.73702348
158MP0003937_abnormal_limbs/digits/tail_de0.73697990
159MP0005369_muscle_phenotype0.73247896
160MP0001943_abnormal_respiration0.72887087
161MP0008995_early_reproductive_senescence0.72199357
162MP0002133_abnormal_respiratory_system0.71934391
163MP0005388_respiratory_system_phenotype0.71934391
164* MP0002925_abnormal_cardiovascular_devel0.70742558
165MP0003567_abnormal_fetal_cardiomyocyte0.69480511
166* MP0010630_abnormal_cardiac_muscle0.69397569
167MP0002095_abnormal_skin_pigmentation0.69319457
168MP0001485_abnormal_pinna_reflex0.68696577
169MP0003385_abnormal_body_wall0.67010267
170MP0003718_maternal_effect0.66967526
171MP0000432_abnormal_head_morphology0.66303936
172MP0008961_abnormal_basal_metabolism0.65977583
173* MP0003861_abnormal_nervous_system0.65228275
174MP0000428_abnormal_craniofacial_morphol0.64955631
175MP0001186_pigmentation_phenotype0.64837862
176MP0005195_abnormal_posterior_eye0.63979097

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)3.72064066
2Thyroid carcinoma (HP:0002890)3.45440230
3Degeneration of the lateral corticospinal tracts (HP:0002314)3.44903123
4Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.44903123
5Protruding tongue (HP:0010808)3.39652242
6Focal seizures (HP:0007359)3.34578724
7Febrile seizures (HP:0002373)3.28103467
8Hyperventilation (HP:0002883)3.26048368
9Blue irides (HP:0000635)3.06499319
10Abnormality of the ischium (HP:0003174)3.06124743
11Horizontal nystagmus (HP:0000666)3.03483330
12Subaortic stenosis (HP:0001682)2.89611910
13Abnormality of the left ventricular outflow tract (HP:0011103)2.89611910
14Atonic seizures (HP:0010819)2.85629838
15Hypoplastic ischia (HP:0003175)2.80758353
16Abnormality of the nasal septum (HP:0000419)2.80746590
17Abnormality of incisor morphology (HP:0011063)2.80119903
18Broad-based gait (HP:0002136)2.76506508
19Volvulus (HP:0002580)2.76029707
20Abnormality of the corticospinal tract (HP:0002492)2.68352691
21Epileptic encephalopathy (HP:0200134)2.67321125
22Cupped ear (HP:0000378)2.65343542
23Cystic hygroma (HP:0000476)2.65306487
24Intestinal atresia (HP:0011100)2.62401020
25Long clavicles (HP:0000890)2.60919700
26Chronic hepatic failure (HP:0100626)2.60281767
27Truncal ataxia (HP:0002078)2.60106257
28Absent speech (HP:0001344)2.57364046
29Tubulointerstitial nephritis (HP:0001970)2.55751272
30Rhabdomyosarcoma (HP:0002859)2.50579138
31Low anterior hairline (HP:0000294)2.45252177
32Abnormal biliary tract morphology (HP:0012440)2.44759923
33Gaze-evoked nystagmus (HP:0000640)2.42349431
34Glioma (HP:0009733)2.40748141
35Hyperkalemia (HP:0002153)2.37821923
36Ependymoma (HP:0002888)2.36962434
37Aqueductal stenosis (HP:0002410)2.35046282
38Biliary tract neoplasm (HP:0100574)2.32564281
39Thickened helices (HP:0000391)2.32539147
40Widely spaced teeth (HP:0000687)2.31271446
41Abnormality of the astrocytes (HP:0100707)2.30359282
42Astrocytoma (HP:0009592)2.30359282
43Gastroesophageal reflux (HP:0002020)2.30354327
44Excessive salivation (HP:0003781)2.29471769
45Drooling (HP:0002307)2.29471769
46Decreased circulating renin level (HP:0003351)2.24764931
47Abnormality of the renal cortex (HP:0011035)2.24416508
48Tented upper lip vermilion (HP:0010804)2.23818932
49* Fair hair (HP:0002286)2.20782488
50Heterotopia (HP:0002282)2.20495498
51Short chin (HP:0000331)2.20459533
52Absence seizures (HP:0002121)2.16614811
53Macroorchidism (HP:0000053)2.15984826
54* Generalized hypopigmentation of hair (HP:0011358)2.15285849
55Renal cortical cysts (HP:0000803)2.15072657
56Exotropia (HP:0000577)2.13217805
57Scanning speech (HP:0002168)2.13066736
58Papillary thyroid carcinoma (HP:0002895)2.12792515
59Progressive cerebellar ataxia (HP:0002073)2.12214441
60Dialeptic seizures (HP:0011146)2.11620119
61Abnormality of chromosome stability (HP:0003220)2.11610568
62Sensory axonal neuropathy (HP:0003390)2.11156941
63Alacrima (HP:0000522)2.09726777
64Visual hallucinations (HP:0002367)2.09160503
65Medulloblastoma (HP:0002885)2.08747196
66Curly hair (HP:0002212)2.07642742
67Abnormal auditory evoked potentials (HP:0006958)2.07224699
68Nemaline bodies (HP:0003798)2.03432201
69Neoplasm of the small intestine (HP:0100833)2.03255426
70Abnormality of the right ventricle (HP:0001707)2.02848365
71Absent frontal sinuses (HP:0002688)2.02043653
72Acute myeloid leukemia (HP:0004808)2.00477338
73Sandal gap (HP:0001852)2.00416875
74Thick eyebrow (HP:0000574)2.00333699
75Spastic gait (HP:0002064)1.98640944
76Calf muscle hypertrophy (HP:0008981)1.98513777
77Abnormality of midbrain morphology (HP:0002418)1.97948573
78Molar tooth sign on MRI (HP:0002419)1.97948573
79Bell-shaped thorax (HP:0001591)1.97764123
80Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.97690195
81Open mouth (HP:0000194)1.96946379
82Abnormality of salivation (HP:0100755)1.96793591
83Hypoplastic labia majora (HP:0000059)1.96128856
84Submucous cleft hard palate (HP:0000176)1.96018434
85Muscle fiber inclusion bodies (HP:0100299)1.95800704
86Portal hypertension (HP:0001409)1.95397427
87Poikilocytosis (HP:0004447)1.93485306
88Neoplasm of striated muscle (HP:0009728)1.93076876
89Abnormality of the epiphyses of the hand (HP:0005924)1.92108862
90Lip pit (HP:0100267)1.92081339
91Decreased lacrimation (HP:0000633)1.92013261
92Buphthalmos (HP:0000557)1.91764239
93Hip dysplasia (HP:0001385)1.88776823
94Stomach cancer (HP:0012126)1.88112934
95Abnormality of the incisor (HP:0000676)1.87439103
96Narrow palate (HP:0000189)1.85346691
972-3 toe syndactyly (HP:0004691)1.85037413
98White forelock (HP:0002211)1.84107804
99Nasolacrimal duct obstruction (HP:0000579)1.83075274
100Infantile muscular hypotonia (HP:0008947)1.82792782
101Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.81431900
102Morphological abnormality of the middle ear (HP:0008609)1.80617022
103Medial flaring of the eyebrow (HP:0010747)1.80353270
104Prominent nose (HP:0000448)1.80323345
105Muscle hypertrophy of the lower extremities (HP:0008968)1.79790418
106Abnormality of the lacrimal duct (HP:0011481)1.79593831
107Aplasia involving bones of the upper limbs (HP:0009823)1.78988523
108Aplasia of the phalanges of the hand (HP:0009802)1.78988523
109Aplasia involving bones of the extremities (HP:0009825)1.78988523
110Acanthocytosis (HP:0001927)1.78048093
111Limb hypertonia (HP:0002509)1.77449113
112Acute lymphatic leukemia (HP:0006721)1.77441789
113Tracheomalacia (HP:0002779)1.76753762
114Vertebral arch anomaly (HP:0008438)1.76435077
115Termporal pattern (HP:0011008)1.75019536
116Insidious onset (HP:0003587)1.75019536
117Generalized tonic-clonic seizures (HP:0002069)1.74291805
118Obsessive-compulsive behavior (HP:0000722)1.74223570
119Abnormality of chromosome segregation (HP:0002916)1.74083381
120Intention tremor (HP:0002080)1.73551601
121Abnormality of the labia majora (HP:0012881)1.73305265
122Smooth philtrum (HP:0000319)1.73201718
123Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.72770364
124Neoplasm of the oral cavity (HP:0100649)1.72258768
125Abnormality of the calf musculature (HP:0001430)1.71699767
126Broad metatarsal (HP:0001783)1.71509354
127T lymphocytopenia (HP:0005403)1.71463137
128* Skull defect (HP:0001362)1.71172265
129Chromsome breakage (HP:0040012)1.70931351
130Large earlobe (HP:0009748)1.70664512
131Highly arched eyebrow (HP:0002553)1.69773782
132Neoplasm of the thyroid gland (HP:0100031)1.69733117
133Abnormality of the hepatic vasculature (HP:0006707)1.69702487
134Short metatarsal (HP:0010743)1.69413172
135Bronchomalacia (HP:0002780)1.68674495
136Overgrowth (HP:0001548)1.68280185
137Intellectual disability, moderate (HP:0002342)1.67996681
138Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.66877074
139Facial diplegia (HP:0001349)1.66637492
140Dysdiadochokinesis (HP:0002075)1.66627041
141Anal stenosis (HP:0002025)1.66621798
142Autoamputation (HP:0001218)1.66452529
143Labial hypoplasia (HP:0000066)1.66351820
144Hemiparesis (HP:0001269)1.65742760
145Cubitus valgus (HP:0002967)1.65462805
146Frequent falls (HP:0002359)1.65394001
147Abnormality of the renal medulla (HP:0100957)1.65360022
148Neoplasm of the adrenal cortex (HP:0100641)1.64109447
149Retinal dysplasia (HP:0007973)1.63961792
150Patchy hypopigmentation of hair (HP:0011365)1.63019909
151Truncal obesity (HP:0001956)1.62773796
152Gait imbalance (HP:0002141)1.62136295
153Genital tract atresia (HP:0001827)1.61866570
154Dysmetria (HP:0001310)1.61448002
155Nephrogenic diabetes insipidus (HP:0009806)1.60728510
156Dysmetric saccades (HP:0000641)1.60686424
157Difficulty running (HP:0009046)1.60615009
158Deeply set eye (HP:0000490)1.60385934
159Nephronophthisis (HP:0000090)1.60136941
160Hypothermia (HP:0002045)1.59774392
161Stereotypic behavior (HP:0000733)1.59768482
162* Abnormality of the nasolacrimal system (HP:0000614)1.59147088
163Dyschromatopsia (HP:0007641)1.59095778
164Tapered finger (HP:0001182)1.59057127
165Pheochromocytoma (HP:0002666)1.58822483
166Pulmonic stenosis (HP:0001642)1.57949043
167Hypoplastic iliac wings (HP:0002866)1.57804254
168Abnormality of the pubic bones (HP:0003172)1.57314950
169Coarse hair (HP:0002208)1.54548320
170Hip contracture (HP:0003273)1.53177909
171Aplasia/Hypoplasia of the tibia (HP:0005772)1.53076355

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.59671012
2MAP2K72.66908133
3NTRK32.54059149
4WNK32.52581727
5LATS12.39714396
6FGFR22.34751180
7OBSCN2.26820961
8NEK92.24888863
9MAP3K42.23410614
10CASK2.13361609
11ACVR1B2.12785677
12MARK12.12040714
13STK392.09010845
14STK38L2.06519732
15MKNK22.05629265
16AKT32.00911847
17INSRR1.91781078
18EIF2AK31.90855205
19BRSK21.86358815
20PIK3CG1.81153214
21PNCK1.80803694
22STK31.77753166
23NEK61.75446568
24CDK31.65602199
25MAP3K21.64807394
26MAPK131.62484714
27SGK21.61991342
28MKNK11.58130193
29WNK11.57919264
30OXSR11.56754295
31EPHA41.48673580
32FRK1.47880909
33NLK1.45477925
34SGK4941.44281978
35SGK2231.44281978
36SGK31.41708453
37PKN11.37042193
38CAMK1G1.32586803
39BRD41.24965993
40TRPM71.23944683
41STK241.21573230
42ZAK1.16754636
43CLK11.16189831
44CAMKK21.15884912
45TIE11.13367983
46NTRK21.11849745
47FER1.10466822
48PIK3CA1.08192573
49PRKCH1.06582306
50TEC1.06579745
51PRKCQ1.03227769
52MAP4K21.01267899
53MAP2K40.99703841
54EPHA30.99149145
55FES0.98122177
56PAK60.97475320
57TSSK60.95418309
58PLK20.95232061
59PRKCE0.95050839
60TXK0.94283687
61ERBB30.93628380
62CCNB10.92788907
63CDK120.86670672
64PRKAA20.86650426
65SIK20.86591534
66YES10.85995894
67MAPK150.85851072
68MAP3K130.85372582
69SGK10.85069255
70CDK50.84449146
71PDGFRB0.82006569
72MARK30.80618847
73KSR10.79483144
74CSNK1A1L0.78652960
75MINK10.77326605
76PTK2B0.76281637
77HIPK20.76004370
78CSNK1G20.74914028
79CDC42BPA0.74801215
80PAK30.73080543
81PRPF4B0.72829919
82IRAK10.71207085
83GRK50.70327473
84MARK20.70243303
85SCYL20.70091084
86UHMK10.69597670
87CAMK2D0.68252614
88JAK10.66773116
89CAMK2B0.66656405
90NUAK10.66606165
91ATM0.65046453
92PRKCG0.64391968
93MELK0.63446330
94RET0.63060706
95EPHB10.62614540
96MAPK70.62217862
97CAMK2A0.61259775
98PLK40.60983655
99DAPK20.60302331
100NEK10.59683158
101FYN0.58267744
102GRK70.58206354
103FGFR30.57521743
104ROCK20.57225975
105TTN0.57055221
106BMPR20.56108039
107RPS6KB10.55091584
108MST40.54725662
109CSNK1G10.54682821
110WNK40.53977935
111TAOK30.53761077
112CAMK40.53160140
113BMPR1B0.52656078
114PRKG10.51946451
115BCR0.51646693
116CAMK1D0.50837477
117PLK30.50773777
118ADRBK20.49845530
119MAP3K100.49683531
120STK40.48198178
121PRKAA10.48113766
122MAP3K70.47782516
123TNK20.47337710
124CSNK1G30.47273686
125DYRK1A0.47253526
126CSNK1D0.47027970
127PDGFRA0.46943953
128SRPK10.46396936
129MAP3K60.46194812
130* GSK3B0.45229726
131MAP3K140.44385530
132MAPK100.43989383
133NTRK10.42251404
134CDK60.42169521
135ADRBK10.42125137
136PHKG20.42100982
137PHKG10.42100982
138PBK0.41577484
139MET0.41175929
140FGFR10.39795482
141STK110.39214043
142PRKCB0.38921727
143ITK0.38888963
144WEE10.38393498
145PRKACB0.37175140
146PRKD10.37020673
147EGFR0.36684060
148TGFBR10.36487830
149CHEK10.33865023
150TTK0.33534052

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.70564039
2Morphine addiction_Homo sapiens_hsa050322.42247731
3Non-homologous end-joining_Homo sapiens_hsa034502.37178088
4Circadian entrainment_Homo sapiens_hsa047132.33315098
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.26382577
6Glutamatergic synapse_Homo sapiens_hsa047242.25988338
7GABAergic synapse_Homo sapiens_hsa047272.07710826
8Long-term potentiation_Homo sapiens_hsa047201.99154593
9Taste transduction_Homo sapiens_hsa047421.96989119
10Serotonergic synapse_Homo sapiens_hsa047261.94498262
11Long-term depression_Homo sapiens_hsa047301.83465545
12Renin secretion_Homo sapiens_hsa049241.80351584
13Amphetamine addiction_Homo sapiens_hsa050311.72277031
14Fanconi anemia pathway_Homo sapiens_hsa034601.70206967
15mTOR signaling pathway_Homo sapiens_hsa041501.67863852
16Axon guidance_Homo sapiens_hsa043601.61545523
17Dopaminergic synapse_Homo sapiens_hsa047281.61169861
18Insulin secretion_Homo sapiens_hsa049111.60827924
19Salivary secretion_Homo sapiens_hsa049701.58496287
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.58232727
21Cholinergic synapse_Homo sapiens_hsa047251.57842957
22Cocaine addiction_Homo sapiens_hsa050301.57500781
23Olfactory transduction_Homo sapiens_hsa047401.49600120
24ABC transporters_Homo sapiens_hsa020101.46079904
25Gastric acid secretion_Homo sapiens_hsa049711.45698843
26TGF-beta signaling pathway_Homo sapiens_hsa043501.45154537
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43539558
28Adherens junction_Homo sapiens_hsa045201.38447349
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.37410780
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36822639
31Oxytocin signaling pathway_Homo sapiens_hsa049211.36357620
32MicroRNAs in cancer_Homo sapiens_hsa052061.36103394
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.34850853
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34584367
35Calcium signaling pathway_Homo sapiens_hsa040201.32071474
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31669408
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30763095
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.29603704
39Basal transcription factors_Homo sapiens_hsa030221.29119704
40Prolactin signaling pathway_Homo sapiens_hsa049171.24715476
41Systemic lupus erythematosus_Homo sapiens_hsa053221.23588328
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.22500138
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22137343
44mRNA surveillance pathway_Homo sapiens_hsa030151.21897929
45ErbB signaling pathway_Homo sapiens_hsa040121.20493737
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17345224
47Phototransduction_Homo sapiens_hsa047441.16809866
48Vascular smooth muscle contraction_Homo sapiens_hsa042701.15698493
49cAMP signaling pathway_Homo sapiens_hsa040241.14939710
50Small cell lung cancer_Homo sapiens_hsa052221.14922205
51Cell cycle_Homo sapiens_hsa041101.13262902
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.12835742
53Regulation of autophagy_Homo sapiens_hsa041401.12791641
54Fatty acid biosynthesis_Homo sapiens_hsa000611.12255180
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10823111
56Oocyte meiosis_Homo sapiens_hsa041141.10570410
57Gap junction_Homo sapiens_hsa045401.09066790
58Synaptic vesicle cycle_Homo sapiens_hsa047211.08872885
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.07307129
60Type II diabetes mellitus_Homo sapiens_hsa049301.06784849
61Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04535986
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03952989
63Propanoate metabolism_Homo sapiens_hsa006401.00743506
64Dilated cardiomyopathy_Homo sapiens_hsa054141.00652157
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99427509
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98851420
67p53 signaling pathway_Homo sapiens_hsa041150.98282355
68Viral carcinogenesis_Homo sapiens_hsa052030.97930622
69GnRH signaling pathway_Homo sapiens_hsa049120.97715683
70Melanogenesis_Homo sapiens_hsa049160.97158407
71Choline metabolism in cancer_Homo sapiens_hsa052310.96466243
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96250058
73RNA degradation_Homo sapiens_hsa030180.94719718
74Chronic myeloid leukemia_Homo sapiens_hsa052200.94259702
75Selenocompound metabolism_Homo sapiens_hsa004500.93440402
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93188368
77Ras signaling pathway_Homo sapiens_hsa040140.93131917
78Estrogen signaling pathway_Homo sapiens_hsa049150.90901027
79MAPK signaling pathway_Homo sapiens_hsa040100.90365070
80Insulin resistance_Homo sapiens_hsa049310.89923997
81Rap1 signaling pathway_Homo sapiens_hsa040150.89320017
82Wnt signaling pathway_Homo sapiens_hsa043100.86881868
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86255548
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.84748567
85Autoimmune thyroid disease_Homo sapiens_hsa053200.83971737
86Proteoglycans in cancer_Homo sapiens_hsa052050.83206811
87Inositol phosphate metabolism_Homo sapiens_hsa005620.83111885
88ECM-receptor interaction_Homo sapiens_hsa045120.82493323
89Dorso-ventral axis formation_Homo sapiens_hsa043200.81398937
90Thyroid hormone synthesis_Homo sapiens_hsa049180.81124267
91Nitrogen metabolism_Homo sapiens_hsa009100.80601099
92Melanoma_Homo sapiens_hsa052180.80217522
93Glioma_Homo sapiens_hsa052140.79896083
94AMPK signaling pathway_Homo sapiens_hsa041520.79242138
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78593022
96Tight junction_Homo sapiens_hsa045300.77644863
97T cell receptor signaling pathway_Homo sapiens_hsa046600.77501764
98Ovarian steroidogenesis_Homo sapiens_hsa049130.76500340
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75464278
100Pancreatic secretion_Homo sapiens_hsa049720.72809117
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71946484
102Focal adhesion_Homo sapiens_hsa045100.69208261
103Prostate cancer_Homo sapiens_hsa052150.68340776
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67638436
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67440283
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66965376
107Platelet activation_Homo sapiens_hsa046110.66870019
108Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66727303
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66234651
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65037783
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64324461
112Alcoholism_Homo sapiens_hsa050340.62561084
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.61444169
114Hippo signaling pathway_Homo sapiens_hsa043900.60473605
115Renal cell carcinoma_Homo sapiens_hsa052110.59487668
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57281070
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56334990
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55789822
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55321291
120Vibrio cholerae infection_Homo sapiens_hsa051100.55137054
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54873964
122Chemokine signaling pathway_Homo sapiens_hsa040620.54007059
123Circadian rhythm_Homo sapiens_hsa047100.53856332
124Measles_Homo sapiens_hsa051620.53624233
125Insulin signaling pathway_Homo sapiens_hsa049100.53453212
126Endometrial cancer_Homo sapiens_hsa052130.52989964
127Butanoate metabolism_Homo sapiens_hsa006500.52893580
128Lysine degradation_Homo sapiens_hsa003100.51720925
129Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51448406
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.48423791
131Colorectal cancer_Homo sapiens_hsa052100.48421640
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48244584
133RNA transport_Homo sapiens_hsa030130.47194045
134Sphingolipid metabolism_Homo sapiens_hsa006000.46711735
135Pathways in cancer_Homo sapiens_hsa052000.45248916
136African trypanosomiasis_Homo sapiens_hsa051430.43018799
137B cell receptor signaling pathway_Homo sapiens_hsa046620.42587866
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42491092
139Collecting duct acid secretion_Homo sapiens_hsa049660.41928389
140Ether lipid metabolism_Homo sapiens_hsa005650.41023827
141Glucagon signaling pathway_Homo sapiens_hsa049220.40900992
142FoxO signaling pathway_Homo sapiens_hsa040680.40442766
143Non-small cell lung cancer_Homo sapiens_hsa052230.38573730
144Pancreatic cancer_Homo sapiens_hsa052120.38175194
145Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37287391

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