UBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K4 trimethylation (GO:0080182)4.99306435
2pre-miRNA processing (GO:0031054)4.90688331
3negative regulation of histone methylation (GO:0031061)4.74428711
4mitotic sister chromatid cohesion (GO:0007064)4.40459224
5histone H3-K4 methylation (GO:0051568)4.20186696
6cytoplasmic mRNA processing body assembly (GO:0033962)4.08058509
7nuclear pore complex assembly (GO:0051292)3.93398788
8peptidyl-lysine trimethylation (GO:0018023)3.90463982
9embryonic process involved in female pregnancy (GO:0060136)3.73914577
10histone H3-K36 demethylation (GO:0070544)3.69419211
11negative regulation of erythrocyte differentiation (GO:0045647)3.58957620
12glucocorticoid receptor signaling pathway (GO:0042921)3.55890880
13peptidyl-lysine dimethylation (GO:0018027)3.54768821
14DNA unwinding involved in DNA replication (GO:0006268)3.53300626
15positive regulation of histone deacetylation (GO:0031065)3.51863868
16monoubiquitinated protein deubiquitination (GO:0035520)3.49557158
17regulation of chromatin binding (GO:0035561)3.48935685
18COPI coating of Golgi vesicle (GO:0048205)3.44008371
19Golgi transport vesicle coating (GO:0048200)3.44008371
20protein localization to endosome (GO:0036010)3.43859628
21histone lysine methylation (GO:0034968)3.42118845
22RNA stabilization (GO:0043489)3.40722938
23mRNA stabilization (GO:0048255)3.40722938
24focal adhesion assembly (GO:0048041)3.35446327
25cell-substrate adherens junction assembly (GO:0007045)3.35446327
26nuclear pore organization (GO:0006999)3.34701634
27histone H2A monoubiquitination (GO:0035518)3.34635275
28histone H3-K9 demethylation (GO:0033169)3.32227068
29positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.30919535
30corticosteroid receptor signaling pathway (GO:0031958)3.30071219
31NLS-bearing protein import into nucleus (GO:0006607)3.29078384
32adherens junction assembly (GO:0034333)3.25386780
33peptidyl-lysine methylation (GO:0018022)3.24110491
34negative regulation of histone modification (GO:0031057)3.18266538
35mRNA splice site selection (GO:0006376)3.17763141
36histone H4-K16 acetylation (GO:0043984)3.16755817
37histone lysine demethylation (GO:0070076)3.16125288
38pore complex assembly (GO:0046931)3.15905160
39histone H3-K9 methylation (GO:0051567)3.15136688
40histone demethylation (GO:0016577)3.13872280
41mitotic chromosome condensation (GO:0007076)3.12537856
42regulation of NFAT protein import into nucleus (GO:0051532)3.12063599
43sister chromatid segregation (GO:0000819)3.11247752
44regulation of histone H3-K27 methylation (GO:0061085)3.07215594
45negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06357641
46negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.05201449
47negative regulation of cell killing (GO:0031342)3.05201449
48regulation of protein polyubiquitination (GO:1902914)3.02279157
49regulation of glucose import in response to insulin stimulus (GO:2001273)3.00750940
50regulation of histone H3-K9 methylation (GO:0051570)3.00477736
51regulation of early endosome to late endosome transport (GO:2000641)2.97833920
52histone H3-K9 modification (GO:0061647)2.97783397
53cellular response to epidermal growth factor stimulus (GO:0071364)2.94663715
54intracellular estrogen receptor signaling pathway (GO:0030520)2.92514138
55cell-substrate junction assembly (GO:0007044)2.92080333
56activation of Rac GTPase activity (GO:0032863)2.90155657
57negative regulation of chromatin modification (GO:1903309)2.86696602
58histone methylation (GO:0016571)2.85078747
59mitotic sister chromatid segregation (GO:0000070)2.83927890
60regulation of clathrin-mediated endocytosis (GO:2000369)2.82973455
61cellular protein complex localization (GO:0034629)2.82960563
62protein export from nucleus (GO:0006611)2.81900228
63response to epidermal growth factor (GO:0070849)2.81601425
64regulation of histone H3-K4 methylation (GO:0051569)2.81568082
65regulation of hippo signaling (GO:0035330)2.81313546
66response to laminar fluid shear stress (GO:0034616)2.78799174
67insulin-like growth factor receptor signaling pathway (GO:0048009)2.78692885
68COPII vesicle coating (GO:0048208)2.78536308
69protein dealkylation (GO:0008214)2.78269103
70protein demethylation (GO:0006482)2.78269103
71regulation of DNA endoreduplication (GO:0032875)2.76373227
72DNA topological change (GO:0006265)2.75710574
73regulation of sister chromatid cohesion (GO:0007063)2.75142968
74pinocytosis (GO:0006907)2.73748400
75protein localization to kinetochore (GO:0034501)2.73072259
76hypotonic response (GO:0006971)2.72906230
77embryonic retina morphogenesis in camera-type eye (GO:0060059)2.69898146
78positive regulation of gene expression, epigenetic (GO:0045815)2.69555067
79regulation of translational fidelity (GO:0006450)2.69534328
80positive regulation of RNA splicing (GO:0033120)2.69288577
81regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.69183252
82regulation of RNA export from nucleus (GO:0046831)2.68895849
83skin morphogenesis (GO:0043589)2.68708586
84negative regulation of fatty acid transport (GO:2000192)2.66679721
85maternal placenta development (GO:0001893)2.65119936
86histone H4-K8 acetylation (GO:0043982)2.64592393
87histone H4-K5 acetylation (GO:0043981)2.64592393
88trophectodermal cell differentiation (GO:0001829)2.64089225
89regulation of histone methylation (GO:0031060)2.63750713
90negative regulation of mRNA processing (GO:0050686)2.61450914
91heterochromatin organization (GO:0070828)2.61336713
92histone H4 acetylation (GO:0043967)2.61140531
93peptidyl-threonine modification (GO:0018210)2.60894370
94regulation of spindle organization (GO:0090224)2.59212416
95stress fiber assembly (GO:0043149)2.58103367
96dosage compensation (GO:0007549)2.57658689
97cytoskeletal anchoring at plasma membrane (GO:0007016)2.56573333
98regulation of mRNA stability (GO:0043488)2.55353048
99mannose metabolic process (GO:0006013)2.54469282
100regulation of gamma-delta T cell differentiation (GO:0045586)2.54060342
101peptidyl-threonine phosphorylation (GO:0018107)2.53735471
102negative regulation of translation, ncRNA-mediated (GO:0040033)2.53573579
103regulation of translation, ncRNA-mediated (GO:0045974)2.53573579
104negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.53573579
105mammary gland epithelial cell proliferation (GO:0033598)2.53369578
106dicarboxylic acid biosynthetic process (GO:0043650)2.53352640
107negative regulation of DNA repair (GO:0045738)2.50927195
108positive T cell selection (GO:0043368)2.49533479
109regulation of mammary gland epithelial cell proliferation (GO:0033599)2.49482561
110regulation of mitotic spindle organization (GO:0060236)2.49353472
111stress granule assembly (GO:0034063)2.49337301
112establishment of nucleus localization (GO:0040023)2.49186862
113negative regulation of mRNA metabolic process (GO:1903312)2.48884904
114nucleosome disassembly (GO:0006337)2.48501163
115protein-DNA complex disassembly (GO:0032986)2.48501163
116negative regulation of RNA splicing (GO:0033119)2.47776376
117regulation of gamma-delta T cell activation (GO:0046643)2.47143276
118vesicle coating (GO:0006901)2.46498598
119positive regulation of gamma-delta T cell activation (GO:0046645)2.46249152
120cortical actin cytoskeleton organization (GO:0030866)2.45649445
121positive regulation of protein deacetylation (GO:0090312)2.45351499
122positive regulation of blood vessel endothelial cell migration (GO:0043536)2.44466859
123regulation of RNA stability (GO:0043487)2.43656750
124maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.43249891
125negative regulation of histone acetylation (GO:0035067)2.42566082
126desmosome organization (GO:0002934)2.42477182
1273-UTR-mediated mRNA stabilization (GO:0070935)2.42172892
128protoporphyrinogen IX metabolic process (GO:0046501)2.41000241
129negative regulation of circadian rhythm (GO:0042754)2.40819792
130alternative mRNA splicing, via spliceosome (GO:0000380)2.40036843
131negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.39879987
132chromatin assembly (GO:0031497)2.39728613
133positive regulation of protein import into nucleus, translocation (GO:0033160)2.39537284
134nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.39170896
135regulation of nucleobase-containing compound transport (GO:0032239)2.38783305
136positive regulation of Cdc42 GTPase activity (GO:0043089)2.38467199
137retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.37504003
138protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.36947637
139protein localization to chromosome, centromeric region (GO:0071459)2.36617927
140embryonic camera-type eye morphogenesis (GO:0048596)2.36020837
141DNA duplex unwinding (GO:0032508)2.35956863
142protein localization to microtubule (GO:0035372)2.35668491
143spliceosomal tri-snRNP complex assembly (GO:0000244)2.34669930
144protein complex localization (GO:0031503)2.33606248
145DNA geometric change (GO:0032392)2.33450641
146positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.33446163
147planar cell polarity pathway involved in neural tube closure (GO:0090179)2.32325217
148gastrulation with mouth forming second (GO:0001702)2.32142296
149embryonic eye morphogenesis (GO:0048048)2.31420192
150activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.30993342
151positive regulation of protein export from nucleus (GO:0046827)2.29044350
152positive regulation of nuclease activity (GO:0032075)2.28403019
153regulation of cholesterol homeostasis (GO:2000188)2.28297022
154protein retention in ER lumen (GO:0006621)2.26409647
155epithelial cell differentiation involved in prostate gland development (GO:0060742)2.25729043
156regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.24967746
157branching involved in mammary gland duct morphogenesis (GO:0060444)2.24358120
158regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.23955702
159positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.21772823
160cellular hyperosmotic response (GO:0071474)2.20382591
161ER-nucleus signaling pathway (GO:0006984)2.18350417
162regulation of nuclease activity (GO:0032069)2.17534696
163basement membrane organization (GO:0071711)2.16612644
164endoplasmic reticulum unfolded protein response (GO:0030968)2.15658274
165modulation by symbiont of host cellular process (GO:0044068)2.14922246
166histone H2B ubiquitination (GO:0033523)2.13647885

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.59921841
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.36883188
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.32070796
4MYC_22102868_ChIP-Seq_BL_Human3.91282325
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.71351654
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.93451112
7TCF7_22412390_ChIP-Seq_EML_Mouse2.84382403
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.82225051
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.51292820
10KDM2B_26808549_Chip-Seq_DND41_Human2.43278382
11KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.40740442
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.37304449
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.22442535
14SCL_19346495_ChIP-Seq_HPC-7_Human2.13963334
15DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.11433813
16AR_21909140_ChIP-Seq_LNCAP_Human2.06760423
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00071763
18KDM2B_26808549_Chip-Seq_SUP-B15_Human1.97780783
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96667414
20E2F4_17652178_ChIP-ChIP_JURKAT_Human1.95266837
21CIITA_25753668_ChIP-Seq_RAJI_Human1.93116459
22VDR_21846776_ChIP-Seq_THP-1_Human1.91836718
23* KDM2B_26808549_Chip-Seq_JURKAT_Human1.89853681
24ZFP281_27345836_Chip-Seq_ESCs_Mouse1.87259580
25TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.74077214
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.73680804
27* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.70043573
28SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.68639306
29GATA1_22025678_ChIP-Seq_K562_Human1.68281988
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.67729597
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67571624
32FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.66369476
33* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.66242509
34UTX_26944678_Chip-Seq_JUKART_Human1.65690669
35* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.63487604
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.63225410
37ZNF263_19887448_ChIP-Seq_K562_Human1.61954835
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.61399555
39RACK7_27058665_Chip-Seq_MCF-7_Human1.60891692
40GATA1_19941826_ChIP-Seq_K562_Human1.59450757
41* KDM2B_26808549_Chip-Seq_K562_Human1.59112460
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58102430
43RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.55197670
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52540340
45MAF_26560356_Chip-Seq_TH1_Human1.52323539
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51625557
47NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.50165111
48* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.44946754
49* GATA1_19941827_ChIP-Seq_MEL_Mouse1.44176110
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43847370
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43760707
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43426447
53CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.43174063
54NCOR1_26117541_ChIP-Seq_K562_Human1.42606709
55* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.41748061
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41698241
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41079681
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.40056273
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39236708
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38941456
61P300_27058665_Chip-Seq_ZR-75-30cells_Human1.38117439
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36870626
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.36608959
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36312000
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.36247738
66RUNX_20019798_ChIP-Seq_JUKART_Human1.32702649
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31589413
68MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31563924
69MYB_26560356_Chip-Seq_TH1_Human1.29707047
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29012957
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26915962
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26596101
73MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26491349
74MYC_18555785_ChIP-Seq_MESCs_Mouse1.26318730
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25815012
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25762813
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25498773
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21830820
79EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21526317
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21187837
81FOXA2_19822575_ChIP-Seq_HepG2_Human1.19442393
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18959604
83KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18380527
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.16752723
85UBF1/2_26484160_Chip-Seq_HMECs_Human1.16515942
86ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16373240
87LXR_22292898_ChIP-Seq_THP-1_Human1.16334076
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.15458042
89ELK3_25401928_ChIP-Seq_HUVEC_Human1.15110850
90SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13973743
91ATF3_27146783_Chip-Seq_COLON_Human1.13279518
92FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.12692032
93* RARB_27405468_Chip-Seq_BRAIN_Mouse1.12458214
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12407165
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12407165
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11980724
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10669544
98HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10586514
99GATA2_19941826_ChIP-Seq_K562_Human1.09173310
100SPI1_23127762_ChIP-Seq_K562_Human1.08063117
101NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08041455
102RUNX1_22412390_ChIP-Seq_EML_Mouse1.07900680
103NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07615315
104MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07105856
105SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07102028
106TP63_19390658_ChIP-ChIP_HaCaT_Human1.05184370
107STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.04453190
108ISL1_27105846_Chip-Seq_CPCs_Mouse1.04439016
109FOXO3_23340844_ChIP-Seq_DLD1_Human1.04215845
110* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04122288
111SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03719572
112VDR_24763502_ChIP-Seq_THP-1_Human1.02944283
113LXR_22158963_ChIP-Seq_LIVER_Mouse1.02478160
114CREB1_26743006_Chip-Seq_LNCaP_Human1.02286449
115GATA6_25053715_ChIP-Seq_YYC3_Human1.01724493
116* KDM5A_27292631_Chip-Seq_BREAST_Human1.01460922
117RUNX1_27514584_Chip-Seq_MCF-7_Human1.00978900
118TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00568443
119STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00081102
120FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99930337
121RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99884236
122STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99876042
123* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99385167
124TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98928485
125EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98631829
126* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98384104
127* TP53_16413492_ChIP-PET_HCT116_Human0.98127246
128CHD1_26751641_Chip-Seq_LNCaP_Human0.97767472
129PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97140950
130FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96569426
131CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95894883
132ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.95372194
133* MYB_26560356_Chip-Seq_TH2_Human0.95249790
134ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94517668
135TFEB_21752829_ChIP-Seq_HELA_Human0.93998435
136CLOCK_20551151_ChIP-Seq_293T_Human0.90137128
137SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89981999
138RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88795907
139CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88786992
140RXR_22158963_ChIP-Seq_LIVER_Mouse0.88410660
141ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88095626
142TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88027947
143* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.87241934

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.77706336
2MP0003705_abnormal_hypodermis_morpholog2.90132479
3MP0003787_abnormal_imprinting2.85623068
4MP0005076_abnormal_cell_differentiation2.67687745
5MP0003111_abnormal_nucleus_morphology2.52306118
6MP0004264_abnormal_extraembryonic_tissu2.47325645
7MP0009278_abnormal_bone_marrow2.41751657
8MP0008438_abnormal_cutaneous_collagen2.38593894
9MP0002009_preneoplasia2.33436574
10MP0004808_abnormal_hematopoietic_stem2.18684088
11MP0005409_darkened_coat_color2.18378709
12MP0010352_gastrointestinal_tract_polyps2.12564495
13MP0001849_ear_inflammation2.08768628
14MP0002396_abnormal_hematopoietic_system2.07400454
15MP0003656_abnormal_erythrocyte_physiolo2.07192789
16MP0001545_abnormal_hematopoietic_system2.05539687
17MP0005397_hematopoietic_system_phenotyp2.05539687
18MP0003303_peritoneal_inflammation2.00270830
19MP0010307_abnormal_tumor_latency1.99788151
20MP0003077_abnormal_cell_cycle1.91003024
21MP0003890_abnormal_embryonic-extraembry1.82905928
22MP0004233_abnormal_muscle_weight1.75673940
23* MP0002086_abnormal_extraembryonic_tissu1.74309710
24MP0002796_impaired_skin_barrier1.71627862
25MP0003300_gastrointestinal_ulcer1.68832769
26MP0005365_abnormal_bile_salt1.67770914
27MP0000350_abnormal_cell_proliferation1.67342453
28MP0008961_abnormal_basal_metabolism1.66345205
29MP0001915_intracranial_hemorrhage1.65714007
30MP0003252_abnormal_bile_duct1.62774632
31MP0001730_embryonic_growth_arrest1.62349518
32MP0003453_abnormal_keratinocyte_physiol1.62322632
33MP0002084_abnormal_developmental_patter1.62097427
34* MP0005380_embryogenesis_phenotype1.61576357
35* MP0001672_abnormal_embryogenesis/_devel1.61576357
36MP0009672_abnormal_birth_weight1.60284448
37MP0010094_abnormal_chromosome_stability1.59127205
38* MP0003984_embryonic_growth_retardation1.55920001
39* MP0002088_abnormal_embryonic_growth/wei1.53644605
40MP0002166_altered_tumor_susceptibility1.52670931
41MP0003566_abnormal_cell_adhesion1.51310721
42MP0009053_abnormal_anal_canal1.48595011
43MP0010234_abnormal_vibrissa_follicle1.46964865
44MP0003121_genomic_imprinting1.46917416
45MP0004197_abnormal_fetal_growth/weight/1.43882094
46MP0005666_abnormal_adipose_tissue1.38265168
47MP0004859_abnormal_synaptic_plasticity1.34436483
48MP0009703_decreased_birth_body1.34157628
49MP0003693_abnormal_embryo_hatching1.32471795
50MP0001348_abnormal_lacrimal_gland1.32011486
51MP0004947_skin_inflammation1.31724236
52MP0000733_abnormal_muscle_development1.30867774
53* MP0001697_abnormal_embryo_size1.30602944
54MP0002085_abnormal_embryonic_tissue1.29965195
55* MP0002925_abnormal_cardiovascular_devel1.28393464
56MP0008057_abnormal_DNA_replication1.27715627
57MP0003123_paternal_imprinting1.25587529
58MP0002877_abnormal_melanocyte_morpholog1.21512027
59MP0002398_abnormal_bone_marrow1.20973491
60MP0006054_spinal_hemorrhage1.20446509
61MP0005394_taste/olfaction_phenotype1.20364648
62MP0005499_abnormal_olfactory_system1.20364648
63MP0000858_altered_metastatic_potential1.19620440
64MP0005501_abnormal_skin_physiology1.19579414
65MP0003115_abnormal_respiratory_system1.17800404
66MP0000703_abnormal_thymus_morphology1.17252140
67MP0005360_urolithiasis1.16903986
68MP0004272_abnormal_basement_membrane1.16902167
69MP0002060_abnormal_skin_morphology1.16773110
70MP0003567_abnormal_fetal_cardiomyocyte1.16669561
71MP0002006_tumorigenesis1.15223973
72MP0008007_abnormal_cellular_replicative1.14466986
73MP0005058_abnormal_lysosome_morphology1.14111527
74MP0005623_abnormal_meninges_morphology1.13967353
75MP0005023_abnormal_wound_healing1.11416206
76* MP0002080_prenatal_lethality1.11353955
77MP0003935_abnormal_craniofacial_develop1.09712696
78MP0003828_pulmonary_edema1.08797052
79MP0005257_abnormal_intraocular_pressure1.08680565
80MP0003943_abnormal_hepatobiliary_system1.07453442
81MP0004782_abnormal_surfactant_physiolog1.05282969
82MP0002928_abnormal_bile_duct1.05203011
83MP0005275_abnormal_skin_tensile1.04549383
84MP0003941_abnormal_skin_development1.04084143
85MP0001293_anophthalmia1.03779574
86MP0008877_abnormal_DNA_methylation1.03725383
87MP0003191_abnormal_cellular_cholesterol1.02521120
88MP0000537_abnormal_urethra_morphology1.02363433
89MP0008770_decreased_survivor_rate1.02153527
90MP0008260_abnormal_autophagy1.01265399
91MP0003172_abnormal_lysosome_physiology1.00934762
92MP0005375_adipose_tissue_phenotype0.99618069
93* MP0010630_abnormal_cardiac_muscle0.98873227
94MP0004858_abnormal_nervous_system0.98530504
95MP0003436_decreased_susceptibility_to0.98514685
96MP0002653_abnormal_ependyma_morphology0.98488333
97MP0000371_diluted_coat_color0.98375621
98MP0002139_abnormal_hepatobiliary_system0.95536206
99* MP0000266_abnormal_heart_morphology0.95282477
100MP0005187_abnormal_penis_morphology0.95070455
101MP0001835_abnormal_antigen_presentation0.94980979
102MP0001853_heart_inflammation0.94660124
103MP0005174_abnormal_tail_pigmentation0.94626214
104MP0000490_abnormal_crypts_of0.93968291
105MP0001216_abnormal_epidermal_layer0.92630810
106MP0003221_abnormal_cardiomyocyte_apopto0.91806022
107MP0002896_abnormal_bone_mineralization0.91793701
108MP0001958_emphysema0.89980606
109MP0000609_abnormal_liver_physiology0.89908746
110MP0002722_abnormal_immune_system0.89836848
111MP0002092_abnormal_eye_morphology0.89059962
112MP0000689_abnormal_spleen_morphology0.88404939
113MP0004885_abnormal_endolymph0.87620614
114MP0002998_abnormal_bone_remodeling0.87077790
115MP0010329_abnormal_lipoprotein_level0.86962487
116MP0000428_abnormal_craniofacial_morphol0.86176417
117MP0000627_abnormal_mammary_gland0.85085711
118MP0005085_abnormal_gallbladder_physiolo0.84712500
119MP0003279_aneurysm0.84190899
120MP0003861_abnormal_nervous_system0.82512419
121MP0005384_cellular_phenotype0.82073501
122MP0003763_abnormal_thymus_physiology0.81928887
123MP0005621_abnormal_cell_physiology0.81469285
124MP0000313_abnormal_cell_death0.80896690
125MP0004957_abnormal_blastocyst_morpholog0.79967138
126MP0006138_congestive_heart_failure0.79673825
127MP0001851_eye_inflammation0.79489764
128MP0005464_abnormal_platelet_physiology0.79232684
129MP0001784_abnormal_fluid_regulation0.78836363
130MP0002089_abnormal_postnatal_growth/wei0.78829109
131MP0003183_abnormal_peptide_metabolism0.78268612
132MP0010678_abnormal_skin_adnexa0.78203106
133MP0001800_abnormal_humoral_immune0.77800777
134MP0009333_abnormal_splenocyte_physiolog0.76734439
135MP0004185_abnormal_adipocyte_glucose0.76364143
136MP0003448_altered_tumor_morphology0.76098832
137MP0009931_abnormal_skin_appearance0.75974312
138MP0000003_abnormal_adipose_tissue0.75840246
139MP0003868_abnormal_feces_composition0.75477508
140MP0005451_abnormal_body_composition0.75227343
141MP0000598_abnormal_liver_morphology0.74738835
142MP0002019_abnormal_tumor_incidence0.73805526
143MP0003119_abnormal_digestive_system0.73206853
144MP0004510_myositis0.72485529
145MP0003091_abnormal_cell_migration0.72464838
146MP0001873_stomach_inflammation0.72194779
147MP0000432_abnormal_head_morphology0.70723419
148MP0000516_abnormal_urinary_system0.70655101
149MP0005367_renal/urinary_system_phenotyp0.70655101
150MP0000767_abnormal_smooth_muscle0.69085895

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.62297939
2Protrusio acetabuli (HP:0003179)3.14788832
3Asymmetry of the thorax (HP:0001555)3.12890567
4Papillary thyroid carcinoma (HP:0002895)3.01422267
5Volvulus (HP:0002580)2.95547836
6Short 4th metacarpal (HP:0010044)2.79174882
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.79174882
8Heterotopia (HP:0002282)2.76946466
9Premature rupture of membranes (HP:0001788)2.74246450
10Ankyloglossia (HP:0010296)2.72742178
11Hypochromic microcytic anemia (HP:0004840)2.71195654
12Macroorchidism (HP:0000053)2.65385687
13Flat acetabular roof (HP:0003180)2.64346146
14Poikilocytosis (HP:0004447)2.58158629
15Broad face (HP:0000283)2.57529242
16Hyperacusis (HP:0010780)2.55150203
17Long eyelashes (HP:0000527)2.43913021
18Abnormality of oral frenula (HP:0000190)2.37471057
19Narrow palate (HP:0000189)2.35328203
20Abnormality of the lower motor neuron (HP:0002366)2.26267411
21Termporal pattern (HP:0011008)2.25657129
22Insidious onset (HP:0003587)2.25657129
23Urethral obstruction (HP:0000796)2.25420815
24Osteolytic defects of the hand bones (HP:0009699)2.21094839
25Osteolytic defects of the phalanges of the hand (HP:0009771)2.21094839
26Abnormality of the distal phalanx of the thumb (HP:0009617)2.19942063
27Dysmetric saccades (HP:0000641)2.19847828
28Arterial tortuosity (HP:0005116)2.17694516
29Abnormality of the 4th metacarpal (HP:0010012)2.15054038
30Obsessive-compulsive behavior (HP:0000722)2.14287345
31Disproportionate tall stature (HP:0001519)2.12243440
32Relative macrocephaly (HP:0004482)2.09875846
33Ependymoma (HP:0002888)2.08510923
34Cerebral aneurysm (HP:0004944)2.08243925
35Shallow orbits (HP:0000586)2.07916423
36Prominent nose (HP:0000448)2.07587876
37Broad palm (HP:0001169)2.04719364
38Sparse lateral eyebrow (HP:0005338)2.03768899
39Renovascular hypertension (HP:0100817)2.03573338
40Astrocytoma (HP:0009592)2.03419613
41Abnormality of the astrocytes (HP:0100707)2.03419613
42Genetic anticipation (HP:0003743)2.03028004
43Thin bony cortex (HP:0002753)2.02741108
44Reticulocytosis (HP:0001923)2.01480517
45Aortic aneurysm (HP:0004942)1.98882562
46Vascular tortuosity (HP:0004948)1.97336711
47Abnormality of the intervertebral disk (HP:0005108)1.97281364
48Insomnia (HP:0100785)1.92566452
49Deep philtrum (HP:0002002)1.92455011
50Vertebral arch anomaly (HP:0008438)1.92331009
51Truncal obesity (HP:0001956)1.92213597
52High pitched voice (HP:0001620)1.91042781
53Malignant gastrointestinal tract tumors (HP:0006749)1.90969484
54Gastrointestinal carcinoma (HP:0002672)1.90969484
55Transitional cell carcinoma of the bladder (HP:0006740)1.90715065
56Increased nuchal translucency (HP:0010880)1.90230758
57Distal lower limb amyotrophy (HP:0008944)1.89961681
58Acanthocytosis (HP:0001927)1.89660780
59Dilatation of the ascending aorta (HP:0005111)1.88619203
60Dislocated radial head (HP:0003083)1.88255016
61Sandal gap (HP:0001852)1.86978402
62Uterine leiomyosarcoma (HP:0002891)1.86330004
63Leiomyosarcoma (HP:0100243)1.86330004
64Increased density of long bones (HP:0006392)1.86140258
65Subacute progressive viral hepatitis (HP:0006572)1.84203809
66Vertebral compression fractures (HP:0002953)1.83932082
67Elfin facies (HP:0004428)1.83897227
68Selective tooth agenesis (HP:0001592)1.83437599
69Medulloblastoma (HP:0002885)1.82477296
70Facial hemangioma (HP:0000329)1.81889934
71Broad thumb (HP:0011304)1.81858596
72Obstructive sleep apnea (HP:0002870)1.81772383
73Short 1st metacarpal (HP:0010034)1.81489665
74Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.81489665
75Aneurysm (HP:0002617)1.80807556
76Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.79961855
77Pseudobulbar signs (HP:0002200)1.79489743
78Long palpebral fissure (HP:0000637)1.78466512
79Acute myeloid leukemia (HP:0004808)1.77931531
80Abnormality of the thoracic spine (HP:0100711)1.77750890
81Mitral valve prolapse (HP:0001634)1.77082338
82Wormian bones (HP:0002645)1.75589408
83Pointed chin (HP:0000307)1.74975275
84Abnormal foot bone ossification (HP:0010675)1.74758112
85Aplasia/Hypoplasia of the sternum (HP:0006714)1.74223876
86Anal stenosis (HP:0002025)1.72651275
87Spastic diplegia (HP:0001264)1.72449134
88Deviation of the thumb (HP:0009603)1.72161167
89Spondylolisthesis (HP:0003302)1.71640548
90Enlarged penis (HP:0000040)1.71635018
91Aortic dissection (HP:0002647)1.69677481
92Bladder carcinoma (HP:0002862)1.69112207
93Bladder neoplasm (HP:0009725)1.69112207
94Neoplasm of striated muscle (HP:0009728)1.69066073
95Skin tags (HP:0010609)1.68878416
96Abnormality of the lumbar spine (HP:0100712)1.68733201
97Long toe (HP:0010511)1.68560317
98Blue sclerae (HP:0000592)1.67627851
99Ulnar bowing (HP:0003031)1.67531904
100Cutis marmorata (HP:0000965)1.67272420
101Metaphyseal cupping (HP:0003021)1.67183273
102Deep palmar crease (HP:0006191)1.66600503
103Abnormality of the radial head (HP:0003995)1.66303811
104Fragile skin (HP:0001030)1.65573219
105Mitral regurgitation (HP:0001653)1.65310495
106Fatigue (HP:0012378)1.64795211
107Absent frontal sinuses (HP:0002688)1.64705582
108Cafe-au-lait spot (HP:0000957)1.64307464
109Trigonocephaly (HP:0000243)1.64054357
110Neoplasm of the oral cavity (HP:0100649)1.64047466
111Thick eyebrow (HP:0000574)1.63286891
112Germ cell neoplasia (HP:0100728)1.63057369
113Basal cell carcinoma (HP:0002671)1.62544704
114Syringomyelia (HP:0003396)1.62391954
115Spinal cord lesions (HP:0100561)1.62391954
116Advanced eruption of teeth (HP:0006288)1.62389570
117Depressed nasal tip (HP:0000437)1.62207588
118Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.62179247
119Cupped ribs (HP:0000887)1.61539231
120Pelvic girdle muscle weakness (HP:0003749)1.61224930
121Ectopic kidney (HP:0000086)1.60677795
122Abnormal ossification of hand bones (HP:0005921)1.60274907
123Renal cell carcinoma (HP:0005584)1.60246800
124Persistence of primary teeth (HP:0006335)1.60072151
125Short phalanx of the thumb (HP:0009660)1.59967366
126Lip pit (HP:0100267)1.59889256
127Skull defect (HP:0001362)1.59730936
128Cervical subluxation (HP:0003308)1.59656479
129Myelodysplasia (HP:0002863)1.59654591
130Overlapping toe (HP:0001845)1.59472330
131Thyroid carcinoma (HP:0002890)1.58959514
132Centrally nucleated skeletal muscle fibers (HP:0003687)1.58630426
133Progressive external ophthalmoplegia (HP:0000590)1.58324494
134Acute lymphatic leukemia (HP:0006721)1.58127833
135Missing ribs (HP:0000921)1.58028110
136Increased connective tissue (HP:0009025)1.57631539
137Hypoplastic labia majora (HP:0000059)1.57553813
138Overgrowth (HP:0001548)1.57026218
139Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.55865750
140Oligodactyly (HP:0012165)1.55769820
141Viral hepatitis (HP:0006562)1.55705387
142Arnold-Chiari malformation (HP:0002308)1.55138674
143Long clavicles (HP:0000890)1.54809763
144Biliary tract neoplasm (HP:0100574)1.54288414
145Broad phalanges of the hand (HP:0009768)1.53867282
146Abnormality of carpal bone ossification (HP:0006257)1.53557462
147Cubitus valgus (HP:0002967)1.53098768
148Achilles tendon contracture (HP:0001771)1.52535702
149Abnormality of the nasal septum (HP:0000419)1.52479893
150Ureteral stenosis (HP:0000071)1.51844146
151Broad finger (HP:0001500)1.51732487
152Biconcave vertebral bodies (HP:0004586)1.51357100
153Genu recurvatum (HP:0002816)1.51282905
154Slow saccadic eye movements (HP:0000514)1.50359575
155Deep venous thrombosis (HP:0002625)1.49687203
156Hematochezia (HP:0002573)1.49659378
157Joint laxity (HP:0001388)1.49058832
158Spina bifida occulta (HP:0003298)1.48862871
159Abnormality of the phalanges of the hallux (HP:0010057)1.48760061
160Abnormality of the calcaneus (HP:0008364)1.48375690
161Lower limb amyotrophy (HP:0007210)1.47584370
162Coarse hair (HP:0002208)1.46809473
163Proximal placement of thumb (HP:0009623)1.46675132
164Abnormality of the acetabulum (HP:0003170)1.44775828
165Esophageal varix (HP:0002040)1.44627308

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.94119944
2PRPF4B3.47893364
3LATS13.11612783
4SMG12.69726792
5PKN22.62476816
6EEF2K2.59072739
7MAP3K102.56940889
8TRIB32.43880499
9SIK22.22759455
10BRD41.91037252
11SGK31.85011258
12CAMK1G1.82784702
13NEK21.68012529
14AKT31.67515137
15SGK21.66831876
16RIPK11.65612037
17SCYL21.63446193
18CDC71.61560765
19MAP3K141.56249073
20CAMK1D1.54696456
21IRAK31.51053961
22MAP3K61.45290336
23MAP4K11.40020683
24CDK61.38692628
25STK31.38448554
26PTK61.37532876
27MAP3K71.34035305
28DAPK21.30815447
29TAOK11.28424554
30SIK11.26294679
31ALK1.24379809
32MTOR1.24134552
33CDC42BPA1.19056900
34CDK41.16805802
35TAOK31.16184403
36RAF11.12746964
37KSR21.10111888
38STK101.07075873
39PRKD31.06756922
40FGFR31.03005683
41PDGFRA1.01590411
42TTN1.00052613
43NEK91.00052134
44MAP3K130.99814160
45STK380.99469785
46LATS20.98671797
47KSR10.96017293
48EPHA40.95792778
49DMPK0.95778932
50TYRO30.94813972
51RIPK40.94611298
52PAK40.94079779
53NEK10.93528412
54GRK60.91523634
55MAP3K40.90653791
56YES10.90484410
57RPS6KA20.89284686
58CHEK10.88554038
59EIF2AK10.88344935
60TTK0.88142394
61MAP2K40.86874858
62PDGFRB0.85636203
63CDK90.84984365
64WNK10.83938880
65SIK30.83555660
66PRKCH0.81392172
67MST1R0.81053822
68RET0.80259275
69MELK0.79147647
70PAK60.76905734
71STK240.76536635
72MARK20.73631428
73JAK20.73312048
74FGFR10.71532143
75ATR0.71229808
76DAPK10.70216426
77SGK10.69119437
78JAK30.68603695
79CDK70.68372648
80CDK20.68090374
81MAP2K30.66612666
82PRKAA10.66513265
83ATM0.66444583
84MAP3K20.65903296
85CHUK0.64708272
86PTK20.64702016
87ZAP700.63207303
88BMX0.62842812
89JAK10.62292213
90MAP3K90.60702465
91PASK0.60540903
92FGFR40.60488326
93PIM10.58692729
94PDPK10.58461018
95HIPK20.58299171
96SGK4940.58254929
97SGK2230.58254929
98CAMK40.57863872
99PRKAA20.57753039
100TSSK60.57039980
101MAPK140.56981895
102TAOK20.55804755
103TYK20.55650370
104EPHB10.54928688
105ERBB30.54857963
106TRPM70.54369833
107IRAK20.54104044
108MAP3K10.53452111
109ERBB40.52919345
110ERBB20.52738490
111STK40.52675986
112HCK0.52209023
113ERN10.51678401
114PAK20.51514603
115MAP3K80.51508988
116FLT30.50574523
117LRRK20.50428603
118ICK0.50029357
119CDK10.49791473
120MET0.49700842
121MAPK110.48872318
122EIF2AK30.48275393
123IRAK40.48066288
124DDR20.48031344
125MARK30.47147857
126MAPK80.47102454
127GSK3B0.47074032
128NTRK10.46981450
129PDK10.46599864
130AKT10.46079141
131EPHA20.45818545
132RPS6KB20.45748536
133SRPK10.45327096
134MAPK100.45196684
135NME20.43631515
136MAPK70.42961532
137PRKD20.40634427
138MKNK10.40352527
139CLK10.37910645
140RPS6KC10.36832383
141RPS6KL10.36832383
142TAF10.35931194
143FGFR20.35897156

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.47880419
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94254753
3Nitrogen metabolism_Homo sapiens_hsa009101.82017437
4mTOR signaling pathway_Homo sapiens_hsa041501.76092390
5Chronic myeloid leukemia_Homo sapiens_hsa052201.74196091
6Non-small cell lung cancer_Homo sapiens_hsa052231.57464893
7Endometrial cancer_Homo sapiens_hsa052131.54669556
8mRNA surveillance pathway_Homo sapiens_hsa030151.49227172
9B cell receptor signaling pathway_Homo sapiens_hsa046621.43356799
10Thyroid hormone signaling pathway_Homo sapiens_hsa049191.32503194
11Insulin resistance_Homo sapiens_hsa049311.31356591
12Other glycan degradation_Homo sapiens_hsa005111.31105614
13Pancreatic cancer_Homo sapiens_hsa052121.28843458
14Colorectal cancer_Homo sapiens_hsa052101.27694521
15MicroRNAs in cancer_Homo sapiens_hsa052061.26848296
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23273828
17Glioma_Homo sapiens_hsa052141.22535169
18Type II diabetes mellitus_Homo sapiens_hsa049301.22237181
19Acute myeloid leukemia_Homo sapiens_hsa052211.19246510
20Neurotrophin signaling pathway_Homo sapiens_hsa047221.17273177
21Notch signaling pathway_Homo sapiens_hsa043301.15605682
22Longevity regulating pathway - mammal_Homo sapiens_hsa042111.12559523
23Prolactin signaling pathway_Homo sapiens_hsa049171.11112630
24Caffeine metabolism_Homo sapiens_hsa002321.10716836
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10594029
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08294339
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08130133
28Amoebiasis_Homo sapiens_hsa051461.07370930
29Prion diseases_Homo sapiens_hsa050201.05102995
30FoxO signaling pathway_Homo sapiens_hsa040681.04723578
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.03983637
32Arginine biosynthesis_Homo sapiens_hsa002201.03953692
33Small cell lung cancer_Homo sapiens_hsa052221.02906427
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02301522
35Long-term potentiation_Homo sapiens_hsa047201.01909009
36Measles_Homo sapiens_hsa051621.00943480
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00812054
38ErbB signaling pathway_Homo sapiens_hsa040120.97677333
39Prostate cancer_Homo sapiens_hsa052150.97252456
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95523164
41Proteoglycans in cancer_Homo sapiens_hsa052050.95061691
42Estrogen signaling pathway_Homo sapiens_hsa049150.95044469
43Dorso-ventral axis formation_Homo sapiens_hsa043200.94256030
44Adherens junction_Homo sapiens_hsa045200.90872286
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90494200
46VEGF signaling pathway_Homo sapiens_hsa043700.89876456
47Bladder cancer_Homo sapiens_hsa052190.89837778
48Thyroid cancer_Homo sapiens_hsa052160.88988031
49Central carbon metabolism in cancer_Homo sapiens_hsa052300.87668810
50Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87329782
51Choline metabolism in cancer_Homo sapiens_hsa052310.86114226
52Hepatitis B_Homo sapiens_hsa051610.86109181
53Osteoclast differentiation_Homo sapiens_hsa043800.85812451
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84399033
55Insulin signaling pathway_Homo sapiens_hsa049100.84202350
56T cell receptor signaling pathway_Homo sapiens_hsa046600.83792157
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83777808
58One carbon pool by folate_Homo sapiens_hsa006700.83160178
59Herpes simplex infection_Homo sapiens_hsa051680.82899732
60Toxoplasmosis_Homo sapiens_hsa051450.82566567
61Cell cycle_Homo sapiens_hsa041100.81459291
62Glucagon signaling pathway_Homo sapiens_hsa049220.79749667
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78952222
64Shigellosis_Homo sapiens_hsa051310.78838061
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78102558
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.77854464
67MAPK signaling pathway_Homo sapiens_hsa040100.76996176
68HTLV-I infection_Homo sapiens_hsa051660.76314894
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75953492
70GnRH signaling pathway_Homo sapiens_hsa049120.75819770
71AMPK signaling pathway_Homo sapiens_hsa041520.74367070
72TNF signaling pathway_Homo sapiens_hsa046680.73125588
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72961147
74Influenza A_Homo sapiens_hsa051640.72629613
75TGF-beta signaling pathway_Homo sapiens_hsa043500.68337346
76Pathways in cancer_Homo sapiens_hsa052000.67833952
77Chemokine signaling pathway_Homo sapiens_hsa040620.67833361
78Olfactory transduction_Homo sapiens_hsa047400.67790660
79Platelet activation_Homo sapiens_hsa046110.66746765
80Oocyte meiosis_Homo sapiens_hsa041140.65696909
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65215164
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.64592459
83Focal adhesion_Homo sapiens_hsa045100.62963757
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.62744068
85Inositol phosphate metabolism_Homo sapiens_hsa005620.62578193
86Viral carcinogenesis_Homo sapiens_hsa052030.60897359
87Renal cell carcinoma_Homo sapiens_hsa052110.60854281
88Bile secretion_Homo sapiens_hsa049760.60162348
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60139414
90Leishmaniasis_Homo sapiens_hsa051400.58830342
91Epstein-Barr virus infection_Homo sapiens_hsa051690.58753875
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58621252
93Melanoma_Homo sapiens_hsa052180.58453848
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57951138
95ECM-receptor interaction_Homo sapiens_hsa045120.57754423
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56690752
97Apoptosis_Homo sapiens_hsa042100.56344207
98Basal cell carcinoma_Homo sapiens_hsa052170.56289916
99Spliceosome_Homo sapiens_hsa030400.56171877
100Pentose phosphate pathway_Homo sapiens_hsa000300.55714672
101Rap1 signaling pathway_Homo sapiens_hsa040150.55665661
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55380999
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54638339
104Endocytosis_Homo sapiens_hsa041440.54430060
105Hippo signaling pathway_Homo sapiens_hsa043900.54237902
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53282018
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53151151
108Hepatitis C_Homo sapiens_hsa051600.52747442
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.52148119
110Circadian rhythm_Homo sapiens_hsa047100.51943527
111RNA transport_Homo sapiens_hsa030130.51740701
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51654122
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.50476175
114Long-term depression_Homo sapiens_hsa047300.50396807
115Selenocompound metabolism_Homo sapiens_hsa004500.50222696
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.49708273
117HIF-1 signaling pathway_Homo sapiens_hsa040660.49383552
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49261006
119Tuberculosis_Homo sapiens_hsa051520.49201134
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48927116
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.48600084
122Salmonella infection_Homo sapiens_hsa051320.47789418
123Melanogenesis_Homo sapiens_hsa049160.45474150
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45163485
125Thyroid hormone synthesis_Homo sapiens_hsa049180.45034914
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44382077

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