UBN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.25628432
2positive regulation by organism of defense response of other organism involved in symbiotic interact5.25628432
3modulation by symbiont of host immune response (GO:0052553)5.25628432
4positive regulation by symbiont of host defense response (GO:0052509)5.25628432
5modulation by symbiont of host defense response (GO:0052031)5.25628432
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.25628432
7positive regulation of gamma-delta T cell activation (GO:0046645)4.89588554
8regulation of gamma-delta T cell differentiation (GO:0045586)4.81266626
9regulation of gamma-delta T cell activation (GO:0046643)4.37936057
10macrophage activation involved in immune response (GO:0002281)4.31273513
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.19864509
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.19864509
13positive regulation of histone deacetylation (GO:0031065)4.17279589
14detection of other organism (GO:0098543)4.15407356
15response to peptidoglycan (GO:0032494)4.14303835
16cellular extravasation (GO:0045123)4.01319616
17neutrophil activation involved in immune response (GO:0002283)3.89584204
18detection of molecule of bacterial origin (GO:0032490)3.85963060
19positive thymic T cell selection (GO:0045059)3.83351220
20detection of bacterium (GO:0016045)3.82567424
21cytoplasmic mRNA processing body assembly (GO:0033962)3.76213910
22regulation of interleukin-12 biosynthetic process (GO:0045075)3.74808555
23antigen processing and presentation of endogenous antigen (GO:0019883)3.69768730
24detection of external biotic stimulus (GO:0098581)3.68960865
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.58856142
26negative regulation of cell killing (GO:0031342)3.58856142
27positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.57674684
28response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.53984239
29response to host (GO:0075136)3.53984239
30response to host defenses (GO:0052200)3.53984239
31response to host immune response (GO:0052572)3.53511923
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.53511923
33histone H3-K36 demethylation (GO:0070544)3.46564436
34positive regulation of B cell differentiation (GO:0045579)3.42722397
35mitotic sister chromatid cohesion (GO:0007064)3.42581295
36positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.39387828
37leukocyte aggregation (GO:0070486)3.38134239
38thymic T cell selection (GO:0045061)3.30196039
39positive T cell selection (GO:0043368)3.29573269
40monoubiquitinated protein deubiquitination (GO:0035520)3.24440054
41negative regulation of erythrocyte differentiation (GO:0045647)3.23201530
42positive regulation of Cdc42 GTPase activity (GO:0043089)3.23116678
43detection of biotic stimulus (GO:0009595)3.20749253
44definitive hemopoiesis (GO:0060216)3.15821077
45regulation of leukocyte degranulation (GO:0043300)3.15687445
46growth hormone receptor signaling pathway (GO:0060396)3.15029019
47macrophage activation (GO:0042116)3.11035539
48histone H3-K9 demethylation (GO:0033169)3.10207615
49regulation of mast cell degranulation (GO:0043304)3.10117680
50JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.09854866
51germinal center formation (GO:0002467)3.06530205
52negative T cell selection (GO:0043383)3.06019244
53histone H3-K4 trimethylation (GO:0080182)3.05241216
54T cell selection (GO:0045058)3.04901138
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.04223451
56neutrophil activation (GO:0042119)3.03665102
57histone lysine demethylation (GO:0070076)3.02560015
58negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.01942466
59positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.01280229
60positive regulation of protein deacetylation (GO:0090312)3.01165659
61positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.00113207
62negative regulation of interleukin-12 production (GO:0032695)2.97313109
63negative thymic T cell selection (GO:0045060)2.97227752
64regulation of myeloid leukocyte mediated immunity (GO:0002886)2.95856879
65protein localization to endosome (GO:0036010)2.95155924
66negative regulation of lymphocyte mediated immunity (GO:0002707)2.94894101
67production of molecular mediator involved in inflammatory response (GO:0002532)2.94635941
68respiratory burst (GO:0045730)2.92155471
69megakaryocyte development (GO:0035855)2.90871065
70lipopolysaccharide-mediated signaling pathway (GO:0031663)2.89851096
71RNA stabilization (GO:0043489)2.89131832
72mRNA stabilization (GO:0048255)2.89131832
73leukocyte migration involved in inflammatory response (GO:0002523)2.88717473
74histone demethylation (GO:0016577)2.86049211
75regulation of necroptotic process (GO:0060544)2.85693268
76histone H3-K4 methylation (GO:0051568)2.85594682
77microglial cell activation (GO:0001774)2.85240544
78regulation of B cell differentiation (GO:0045577)2.85111538
79granulocyte activation (GO:0036230)2.81980811
80regulation of RNA export from nucleus (GO:0046831)2.80743444
81dosage compensation (GO:0007549)2.80236493
82neutrophil mediated immunity (GO:0002446)2.78051805
83myeloid cell activation involved in immune response (GO:0002275)2.75093064
84regulation of mast cell activation involved in immune response (GO:0033006)2.73412597
85natural killer cell differentiation (GO:0001779)2.72414079
86regulation of B cell receptor signaling pathway (GO:0050855)2.71235935
87nuclear pore complex assembly (GO:0051292)2.71124961
88glucocorticoid receptor signaling pathway (GO:0042921)2.70968120
89peptidyl-lysine dimethylation (GO:0018027)2.69843778
90negative regulation of leukocyte mediated immunity (GO:0002704)2.69792316
91embryonic process involved in female pregnancy (GO:0060136)2.67873413
92cellular response to growth hormone stimulus (GO:0071378)2.67474174
93negative regulation of toll-like receptor signaling pathway (GO:0034122)2.66821816
94response to laminar fluid shear stress (GO:0034616)2.66678795
95corticosteroid receptor signaling pathway (GO:0031958)2.65339270
96mitotic chromosome condensation (GO:0007076)2.65176533
97regulation of T-helper 2 cell differentiation (GO:0045628)2.63875359
98antigen processing and presentation via MHC class Ib (GO:0002475)2.61164558
99negative regulation of histone methylation (GO:0031061)2.59731403
100regulation of nucleobase-containing compound transport (GO:0032239)2.59287105
101regulation of regulated secretory pathway (GO:1903305)2.59283293
102hypotonic response (GO:0006971)2.58098344
103germ cell migration (GO:0008354)2.57610974
104peptidyl-lysine trimethylation (GO:0018023)2.57484712
105regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.55935738
106protein dealkylation (GO:0008214)2.55890377
107protein demethylation (GO:0006482)2.55890377
108negative regulation of translation, ncRNA-mediated (GO:0040033)2.54412031
109regulation of translation, ncRNA-mediated (GO:0045974)2.54412031
110negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.54412031
111epithelial cell differentiation involved in prostate gland development (GO:0060742)2.53746721
112insulin-like growth factor receptor signaling pathway (GO:0048009)2.53467322
113negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.53217490
114negative regulation of granulocyte differentiation (GO:0030853)2.52636711
115hepatocyte apoptotic process (GO:0097284)2.51826123
116positive regulation of cellular amide metabolic process (GO:0034250)2.50880069
117immunoglobulin mediated immune response (GO:0016064)2.49263322
118positive regulation of interferon-alpha production (GO:0032727)2.47634745
119tolerance induction (GO:0002507)2.47583660
120gene silencing by RNA (GO:0031047)2.47322657
121regulation of erythrocyte differentiation (GO:0045646)2.47202891
122histone H3-K9 modification (GO:0061647)2.45775352
123embryonic hemopoiesis (GO:0035162)2.45672674
124histone H3-K9 methylation (GO:0051567)2.45465912
125negative regulation of T cell mediated immunity (GO:0002710)2.44392982
126regulation of histone H3-K27 methylation (GO:0061085)2.42848671
127response to interleukin-15 (GO:0070672)2.42827177
128coronary vasculature morphogenesis (GO:0060977)2.42298420
129negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.41992360
130response to UV-C (GO:0010225)2.40642742
131mannose metabolic process (GO:0006013)2.40123245
132regulation of type I interferon-mediated signaling pathway (GO:0060338)2.39232965
133histone lysine methylation (GO:0034968)2.38212426
134gene silencing (GO:0016458)2.37633065
135negative regulation of necroptotic process (GO:0060546)2.37363840
136regulation of platelet aggregation (GO:0090330)2.36695161
137pre-miRNA processing (GO:0031054)2.36566378
138regulation of DNA endoreduplication (GO:0032875)2.35151547
139regulation of chromatin binding (GO:0035561)2.33122456
1403-UTR-mediated mRNA stabilization (GO:0070935)2.32099940
141I-kappaB phosphorylation (GO:0007252)2.31925698
142histone mRNA catabolic process (GO:0071044)2.31747889
143response to type I interferon (GO:0034340)2.31551817
144nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.31494333
145negative regulation of viral release from host cell (GO:1902187)2.30956113
146B cell receptor signaling pathway (GO:0050853)2.30832244
147positive regulation of natural killer cell differentiation (GO:0032825)2.30801073
148positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.30418385
149type I interferon signaling pathway (GO:0060337)2.30277128
150cellular response to type I interferon (GO:0071357)2.30277128
151positive regulation of receptor recycling (GO:0001921)2.30096794
152positive regulation of erythrocyte differentiation (GO:0045648)2.29699436
153T cell homeostasis (GO:0043029)2.29314225
154regulation of histone deacetylation (GO:0031063)2.28652987
155chromatin assembly (GO:0031497)2.28589940
156NLS-bearing protein import into nucleus (GO:0006607)2.27154001
157pore complex assembly (GO:0046931)2.25881717
158lymphocyte homeostasis (GO:0002260)2.24414484
159regulation of interferon-beta biosynthetic process (GO:0045357)2.23656745
160positive regulation of gene expression, epigenetic (GO:0045815)2.23216385
161NIK/NF-kappaB signaling (GO:0038061)2.22667473
162mucosal-associated lymphoid tissue development (GO:0048537)2.22460208
163Peyers patch development (GO:0048541)2.22460208
164translesion synthesis (GO:0019985)2.21974760
165interferon-gamma production (GO:0032609)2.21083879
166negative regulation of phagocytosis (GO:0050765)2.20874713
167V(D)J recombination (GO:0033151)2.20679021
168peptidyl-lysine methylation (GO:0018022)2.18913089
169nuclear pore organization (GO:0006999)2.18575430
170negative regulation of bone resorption (GO:0045779)2.18497490
171response to muramyl dipeptide (GO:0032495)2.16372102
172T cell costimulation (GO:0031295)2.16198200

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.38226290
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.11306418
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.05998495
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.01263076
5MYC_22102868_ChIP-Seq_BL_Human3.84595381
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.44182384
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.35039757
8TCF7_22412390_ChIP-Seq_EML_Mouse2.99033751
9VDR_21846776_ChIP-Seq_THP-1_Human2.81844251
10SCL_19346495_ChIP-Seq_HPC-7_Human2.80132371
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.60823168
12KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.57395076
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.51270504
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.43408765
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.41555710
16KDM2B_26808549_Chip-Seq_DND41_Human2.40780563
17MAF_26560356_Chip-Seq_TH1_Human2.37086716
18RUNX_20019798_ChIP-Seq_JUKART_Human2.35654426
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.34992209
20UTX_26944678_Chip-Seq_JUKART_Human2.33777139
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.25753930
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.22903367
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.21001993
24TP63_17297297_ChIP-ChIP_HaCaT_Human2.18738147
25KDM2B_26808549_Chip-Seq_SUP-B15_Human2.14836168
26MYB_26560356_Chip-Seq_TH2_Human2.10926243
27MYB_26560356_Chip-Seq_TH1_Human2.06224300
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02730195
29MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02064445
30BP1_19119308_ChIP-ChIP_Hs578T_Human2.01145829
31LXR_22292898_ChIP-Seq_THP-1_Human2.00787965
32BRD4_27068464_Chip-Seq_AML-cells_Mouse2.00075236
33VDR_24763502_ChIP-Seq_THP-1_Human1.99200261
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88207571
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86990658
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.84848118
37RACK7_27058665_Chip-Seq_MCF-7_Human1.84404308
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.81991386
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.80221327
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.77808431
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.77482186
42TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.77230207
43SPI1_23127762_ChIP-Seq_K562_Human1.76846971
44KDM2B_26808549_Chip-Seq_JURKAT_Human1.75587867
45IRF8_27001747_Chip-Seq_BMDM_Mouse1.75288082
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.73451565
47GATA1_22025678_ChIP-Seq_K562_Human1.66698969
48* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.58225706
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51365020
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.50689391
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.45949208
52CIITA_25753668_ChIP-Seq_RAJI_Human1.43186015
53PKCTHETA_26484144_Chip-Seq_BREAST_Human1.43021418
54* NCOR1_26117541_ChIP-Seq_K562_Human1.42985815
55* GATA3_27048872_Chip-Seq_THYMUS_Human1.42597741
56GATA1_19941826_ChIP-Seq_K562_Human1.39735671
57DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.39674406
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38078090
59* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36993956
60MAF_26560356_Chip-Seq_TH2_Human1.34271295
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.33701423
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32514780
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.31155550
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.29522012
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29469546
66FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.28984907
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27875795
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25269525
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25232793
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24469959
71CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22771697
72STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22126541
73CLOCK_20551151_ChIP-Seq_293T_Human1.21780611
74SPI1_23547873_ChIP-Seq_NB4_Human1.21664648
75PU_27001747_Chip-Seq_BMDM_Mouse1.20637005
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18244499
77IRF8_21731497_ChIP-ChIP_J774_Mouse1.17600759
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17226439
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16775409
80GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16188309
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14576405
82FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.14382601
83E2F1_21310950_ChIP-Seq_MCF-7_Human1.13690878
84KDM2B_26808549_Chip-Seq_K562_Human1.13057449
85ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12893009
86GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12679912
87E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08055989
88FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07886730
89FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07609711
90* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06923612
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06499647
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06364276
93ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05766041
94* GATA2_19941826_ChIP-Seq_K562_Human1.05729408
95EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05121663
96PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04967168
97CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04592090
98EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04456736
99P68_20966046_ChIP-Seq_HELA_Human1.04187928
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03630998
101ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02905827
102SMC4_20622854_ChIP-Seq_HELA_Human1.02797326
103SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02596548
104CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01969757
105CREB1_26743006_Chip-Seq_LNCaP_Human1.01593892
106RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01586988
107MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01436436
108KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01384831
109PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01079690
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00254262
111NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99718302
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99567118
113TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99281924
114* GATA6_25053715_ChIP-Seq_YYC3_Human0.97614599
115* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96924620
116RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96917728
117SA1_27219007_Chip-Seq_ERYTHROID_Human0.96697417
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96601134
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95989300
120Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95714053
121RUNX1_27514584_Chip-Seq_MCF-7_Human0.94613220
122PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94105702
123GATA2_21666600_ChIP-Seq_HMVEC_Human0.94098979
124* UBF1/2_26484160_Chip-Seq_HMECs_Human0.93766935
125VDR_24787735_ChIP-Seq_THP-1_Human0.93309099
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92709094
127* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92687937
128ATF3_27146783_Chip-Seq_COLON_Human0.92534791
129KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91330155
130EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90116358

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.32645329
2MP0005451_abnormal_body_composition3.18891357
3MP0003724_increased_susceptibility_to2.88874799
4MP0000569_abnormal_digit_pigmentation2.82822425
5MP0008260_abnormal_autophagy2.67988498
6MP0005076_abnormal_cell_differentiation2.51676100
7MP0002396_abnormal_hematopoietic_system2.49851888
8MP0003763_abnormal_thymus_physiology2.44482468
9MP0002166_altered_tumor_susceptibility2.41548751
10MP0003303_peritoneal_inflammation2.39170084
11MP0009278_abnormal_bone_marrow2.36302701
12MP0003191_abnormal_cellular_cholesterol2.35491658
13MP0004808_abnormal_hematopoietic_stem2.32277726
14MP0003705_abnormal_hypodermis_morpholog2.19578547
15MP0002877_abnormal_melanocyte_morpholog2.11963328
16MP0000685_abnormal_immune_system2.02508312
17MP0008961_abnormal_basal_metabolism2.00353542
18MP0001835_abnormal_antigen_presentation1.91020888
19MP0001800_abnormal_humoral_immune1.90791183
20MP0010352_gastrointestinal_tract_polyps1.87388450
21MP0004185_abnormal_adipocyte_glucose1.86797948
22MP0002398_abnormal_bone_marrow1.86790531
23MP0004510_myositis1.80412747
24MP0000703_abnormal_thymus_morphology1.78233866
25MP0010234_abnormal_vibrissa_follicle1.75339440
26MP0005397_hematopoietic_system_phenotyp1.69335064
27MP0001545_abnormal_hematopoietic_system1.69335064
28MP0002006_tumorigenesis1.69121516
29MP0005464_abnormal_platelet_physiology1.68096187
30MP0010307_abnormal_tumor_latency1.67551975
31MP0002452_abnormal_antigen_presenting1.64326478
32MP0003787_abnormal_imprinting1.63314831
33MP0005387_immune_system_phenotype1.61707658
34MP0001790_abnormal_immune_system1.61707658
35MP0005058_abnormal_lysosome_morphology1.61595636
36MP0004381_abnormal_hair_follicle1.60458731
37MP0003436_decreased_susceptibility_to1.60419256
38MP0005409_darkened_coat_color1.59739220
39MP0005671_abnormal_response_to1.58729105
40MP0002420_abnormal_adaptive_immunity1.58541060
41MP0001819_abnormal_immune_cell1.56305500
42MP0004947_skin_inflammation1.53930362
43MP0003453_abnormal_keratinocyte_physiol1.51525814
44MP0002723_abnormal_immune_serum1.50657271
45MP0000716_abnormal_immune_system1.47584422
46MP0002722_abnormal_immune_system1.47109878
47MP0000465_gastrointestinal_hemorrhage1.42300883
48MP0002405_respiratory_system_inflammati1.40094121
49MP0010155_abnormal_intestine_physiology1.39564646
50MP0000689_abnormal_spleen_morphology1.39285594
51MP0000733_abnormal_muscle_development1.39261853
52MP0009785_altered_susceptibility_to1.39058402
53MP0006054_spinal_hemorrhage1.37000479
54MP0003566_abnormal_cell_adhesion1.36750843
55MP0004858_abnormal_nervous_system1.35536668
56MP0005000_abnormal_immune_tolerance1.35456737
57MP0005310_abnormal_salivary_gland1.34618732
58MP0002132_abnormal_respiratory_system1.32211256
59MP0002796_impaired_skin_barrier1.31384309
60MP0003656_abnormal_erythrocyte_physiolo1.30063126
61MP0003828_pulmonary_edema1.29914226
62MP0001873_stomach_inflammation1.29871012
63MP0002429_abnormal_blood_cell1.28247271
64MP0008007_abnormal_cellular_replicative1.25878834
65MP0003045_fibrosis1.25732558
66MP0004233_abnormal_muscle_weight1.25350958
67MP0009333_abnormal_splenocyte_physiolog1.23799420
68MP0001849_ear_inflammation1.22176315
69MP0005174_abnormal_tail_pigmentation1.19751137
70MP0005666_abnormal_adipose_tissue1.17957554
71MP0002419_abnormal_innate_immunity1.16552604
72MP0003866_abnormal_defecation1.14371587
73MP0001915_intracranial_hemorrhage1.11907662
74MP0004264_abnormal_extraembryonic_tissu1.08799951
75MP0003111_abnormal_nucleus_morphology1.08640830
76MP0005025_abnormal_response_to1.08336736
77MP0002928_abnormal_bile_duct1.07678996
78MP0005375_adipose_tissue_phenotype1.06687608
79MP0002148_abnormal_hypersensitivity_rea1.03485763
80MP0003091_abnormal_cell_migration1.02541238
81MP0008877_abnormal_DNA_methylation1.01626930
82MP0000490_abnormal_crypts_of1.01591747
83MP0000003_abnormal_adipose_tissue1.00881242
84MP0003221_abnormal_cardiomyocyte_apopto1.00084748
85MP0010094_abnormal_chromosome_stability0.98510557
86MP0004883_abnormal_blood_vessel0.98429345
87MP0003077_abnormal_cell_cycle0.97536446
88MP0001845_abnormal_inflammatory_respons0.96653989
89MP0003172_abnormal_lysosome_physiology0.96248101
90MP0002086_abnormal_extraembryonic_tissu0.96029247
91MP0005621_abnormal_cell_physiology0.95684966
92MP0000350_abnormal_cell_proliferation0.94240624
93MP0002019_abnormal_tumor_incidence0.94071518
94MP0005501_abnormal_skin_physiology0.94035738
95MP0008057_abnormal_DNA_replication0.91107308
96MP0003183_abnormal_peptide_metabolism0.90710528
97MP0004197_abnormal_fetal_growth/weight/0.90071214
98MP0005083_abnormal_biliary_tract0.89680726
99MP0003984_embryonic_growth_retardation0.87665554
100MP0000678_abnormal_parathyroid_gland0.87002426
101MP0002009_preneoplasia0.86924225
102MP0002088_abnormal_embryonic_growth/wei0.86669286
103MP0002998_abnormal_bone_remodeling0.86410618
104MP0001853_heart_inflammation0.86221877
105MP0000858_altered_metastatic_potential0.85611720
106MP0000767_abnormal_smooth_muscle0.85528497
107MP0008995_early_reproductive_senescence0.84814428
108MP0009840_abnormal_foam_cell0.84667199
109MP0003693_abnormal_embryo_hatching0.83670238
110MP0002925_abnormal_cardiovascular_devel0.83442130
111MP0010630_abnormal_cardiac_muscle0.82869475
112MP0005164_abnormal_response_to0.82681800
113MP0001958_emphysema0.81664619
114MP0005023_abnormal_wound_healing0.80205208
115MP0008469_abnormal_protein_level0.78871684
116MP0004130_abnormal_muscle_cell0.78625147
117MP0009931_abnormal_skin_appearance0.78184380
118MP0000015_abnormal_ear_pigmentation0.78079515
119MP0008004_abnormal_stomach_pH0.77926317
120MP0003448_altered_tumor_morphology0.77894141
121MP0002933_joint_inflammation0.77797903
122MP0006082_CNS_inflammation0.77650833
123MP0005670_abnormal_white_adipose0.76302799
124MP0001851_eye_inflammation0.76139801
125MP0002060_abnormal_skin_morphology0.76105727
126MP0001672_abnormal_embryogenesis/_devel0.75899526
127MP0005380_embryogenesis_phenotype0.75899526
128MP0003075_altered_response_to0.75157666
129MP0000371_diluted_coat_color0.75071717
130MP0001348_abnormal_lacrimal_gland0.74307810
131MP0001533_abnormal_skeleton_physiology0.74297342
132MP0009115_abnormal_fat_cell0.74153065
133MP0005257_abnormal_intraocular_pressure0.72770498
134MP0001730_embryonic_growth_arrest0.71194755

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.65110345
2Abnormality of macrophages (HP:0004311)3.63509136
3Recurrent gram-negative bacterial infections (HP:0005420)3.20222815
4Orchitis (HP:0100796)3.14021380
5Cerebral aneurysm (HP:0004944)3.10755512
6Hyperacusis (HP:0010780)3.05836121
7Gastrointestinal infarctions (HP:0005244)3.04008542
8Volvulus (HP:0002580)3.00297545
9Gingivitis (HP:0000230)2.98908625
10Recurrent viral infections (HP:0004429)2.86896416
11Obstructive lung disease (HP:0006536)2.82165848
12Chronic obstructive pulmonary disease (HP:0006510)2.82165848
13Increased connective tissue (HP:0009025)2.72304950
14Optic neuritis (HP:0100653)2.71385092
15Retrobulbar optic neuritis (HP:0100654)2.71385092
16Abnormal delayed hypersensitivity skin test (HP:0002963)2.65042374
17Recurrent fungal infections (HP:0002841)2.60584262
18Mediastinal lymphadenopathy (HP:0100721)2.60136886
19Long eyelashes (HP:0000527)2.57755935
20Macroorchidism (HP:0000053)2.55603224
21Hematochezia (HP:0002573)2.54636280
22Cellulitis (HP:0100658)2.54404506
23T lymphocytopenia (HP:0005403)2.51783909
24Aortic aneurysm (HP:0004942)2.46224482
25Autoimmune thrombocytopenia (HP:0001973)2.41293927
26Peritonitis (HP:0002586)2.41117847
27Acute myeloid leukemia (HP:0004808)2.39410473
28Recurrent skin infections (HP:0001581)2.38388508
29Urticaria (HP:0001025)2.36395000
30Abnormality of T cell number (HP:0011839)2.34558688
31Chronic otitis media (HP:0000389)2.33122840
32Inflammation of the large intestine (HP:0002037)2.33104625
33Spontaneous hematomas (HP:0007420)2.31718228
34Slow saccadic eye movements (HP:0000514)2.30322716
35Gastrointestinal inflammation (HP:0004386)2.30126222
36Polycythemia (HP:0001901)2.27657484
37Subacute progressive viral hepatitis (HP:0006572)2.20604578
38Colitis (HP:0002583)2.19482031
39Distal lower limb amyotrophy (HP:0008944)2.18415105
40Recurrent bronchitis (HP:0002837)2.18013737
41Obstructive sleep apnea (HP:0002870)2.17549896
42Panhypogammaglobulinemia (HP:0003139)2.17147554
43Heterotopia (HP:0002282)2.15550576
44Keratoconjunctivitis sicca (HP:0001097)2.15135923
45Prolonged bleeding time (HP:0003010)2.14816478
46Metaphyseal cupping (HP:0003021)2.14497044
47Aneurysm (HP:0002617)2.11180220
48Mitral valve prolapse (HP:0001634)2.08834148
49Nasal polyposis (HP:0100582)2.08790966
50Eczematoid dermatitis (HP:0000976)2.08189555
51Abnormal platelet function (HP:0011869)2.07665300
52Impaired platelet aggregation (HP:0003540)2.07665300
53Centrally nucleated skeletal muscle fibers (HP:0003687)2.07427717
54Truncal obesity (HP:0001956)2.06838158
55Hypochromic anemia (HP:0001931)2.03445244
56Elfin facies (HP:0004428)2.02641991
57Urethral obstruction (HP:0000796)2.02571430
58Broad face (HP:0000283)2.02488865
59Distal lower limb muscle weakness (HP:0009053)2.02369666
60Thin bony cortex (HP:0002753)2.02123672
61Renovascular hypertension (HP:0100817)2.01477489
62Vasculitis (HP:0002633)2.01128611
63Abnormality of the peritoneum (HP:0002585)2.00995328
64Prominent nose (HP:0000448)2.00969501
65Segmental peripheral demyelination/remyelination (HP:0003481)2.00408816
66Ulnar bowing (HP:0003031)2.00388520
67Narrow palate (HP:0000189)2.00287470
68Arterial thrombosis (HP:0004420)1.97697505
69Increased density of long bones (HP:0006392)1.97301010
70Bicuspid aortic valve (HP:0001647)1.97101988
71Persistence of primary teeth (HP:0006335)1.96289903
72Abnormality of the nasal mucosa (HP:0000433)1.96132653
73Lip pit (HP:0100267)1.95121953
74Myocardial infarction (HP:0001658)1.93380513
75Papilloma (HP:0012740)1.93215217
76Verrucae (HP:0200043)1.93215217
77Abnormality of skeletal muscle fiber size (HP:0012084)1.93195662
78Abnormality of T cells (HP:0002843)1.92588649
79Increased variability in muscle fiber diameter (HP:0003557)1.92425894
80Pustule (HP:0200039)1.91717310
81Chest pain (HP:0100749)1.91311203
82Disproportionate tall stature (HP:0001519)1.89995512
83Difficulty running (HP:0009046)1.89637111
84Ankyloglossia (HP:0010296)1.89531328
85Thyroiditis (HP:0100646)1.89320262
86Abnormal platelet volume (HP:0011876)1.89124849
87Hypochromic microcytic anemia (HP:0004840)1.88223063
88Increased nuchal translucency (HP:0010880)1.88005775
89Agammaglobulinemia (HP:0004432)1.86532540
90B lymphocytopenia (HP:0010976)1.86328103
91Abnormality of B cell number (HP:0010975)1.86328103
92Dislocated radial head (HP:0003083)1.86004045
93Broad palm (HP:0001169)1.85900493
94Periodontitis (HP:0000704)1.84504053
95Thrombocytosis (HP:0001894)1.83783606
96IgM deficiency (HP:0002850)1.83755947
97Fatigue (HP:0012378)1.83317640
98Myositis (HP:0100614)1.83130790
99Leukocytosis (HP:0001974)1.82388069
100Eosinophilia (HP:0001880)1.82080774
101Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.81659865
102Viral hepatitis (HP:0006562)1.80224130
103Recurrent cutaneous fungal infections (HP:0011370)1.79412790
104Chronic mucocutaneous candidiasis (HP:0002728)1.79412790
105Cutis marmorata (HP:0000965)1.78948978
106Abnormality of the distal phalanx of the thumb (HP:0009617)1.78306039
107Recurrent bacterial skin infections (HP:0005406)1.77764384
108Flat acetabular roof (HP:0003180)1.76912534
109Vertebral arch anomaly (HP:0008438)1.76577876
110Encephalitis (HP:0002383)1.76443011
111Keratoconjunctivitis (HP:0001096)1.76363049
112Stomatitis (HP:0010280)1.74195156
113Increased IgE level (HP:0003212)1.73904893
114Obsessive-compulsive behavior (HP:0000722)1.73623017
115Asymmetry of the thorax (HP:0001555)1.73565361
116Sepsis (HP:0100806)1.73333018
117Absent frontal sinuses (HP:0002688)1.73324824
118Enlarged penis (HP:0000040)1.72467992
119Short 4th metacarpal (HP:0010044)1.72331905
120Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.72331905
121Gingival bleeding (HP:0000225)1.72264280
122Skin ulcer (HP:0200042)1.72159035
123Interstitial pulmonary disease (HP:0006530)1.71968449
124Increased mean platelet volume (HP:0011877)1.71498414
125Decreased motor nerve conduction velocity (HP:0003431)1.71202821
126Petechiae (HP:0000967)1.70882230
127Abnormality of the radial head (HP:0003995)1.70643105
128Dilatation of the ascending aorta (HP:0005111)1.70019341
129Micronodular cirrhosis (HP:0001413)1.69613741
130Amyloidosis (HP:0011034)1.69356735
131Abnormality of the thoracic spine (HP:0100711)1.68971429
132Meningitis (HP:0001287)1.67073611
133Spinal cord lesions (HP:0100561)1.66571115
134Syringomyelia (HP:0003396)1.66571115
135High pitched voice (HP:0001620)1.65528761
136Epistaxis (HP:0000421)1.65092160
137Difficulty climbing stairs (HP:0003551)1.65035530
138Long palpebral fissure (HP:0000637)1.64275728
139Recurrent abscess formation (HP:0002722)1.64264306
140Transitional cell carcinoma of the bladder (HP:0006740)1.63522912
141Abnormality of oral frenula (HP:0000190)1.63225844
142Spondylolisthesis (HP:0003302)1.61669321
143Elevated erythrocyte sedimentation rate (HP:0003565)1.61480975
144Thick eyebrow (HP:0000574)1.61397580
145Abnormality of the endocardium (HP:0004306)1.61054807
146Osteomyelitis (HP:0002754)1.61026432
147Onion bulb formation (HP:0003383)1.60995108
148Severe short stature (HP:0003510)1.60715339
149Menorrhagia (HP:0000132)1.60519969
150Abnormality of the intervertebral disk (HP:0005108)1.60006112
151Genu recurvatum (HP:0002816)1.59784981
152Hemoptysis (HP:0002105)1.59608192
153Thoracic kyphosis (HP:0002942)1.59422619
154Increased serum ferritin (HP:0003281)1.58371192
155Polygenic inheritance (HP:0010982)1.58303836
156Episodic fever (HP:0001954)1.54542291
157Hemorrhage of the eye (HP:0011885)1.54088979

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.54993248
2PRPF4B3.54569739
3TRIB33.37097212
4RIPK43.24655942
5CDK123.19009145
6MAP4K13.15720530
7LATS13.09329399
8MAP3K102.75414388
9PKN22.65491913
10SMG12.22969809
11TAOK32.04483813
12JAK31.90876520
13BLK1.86823529
14BRD41.85357568
15PTK61.83279679
16ERN11.81572876
17KSR21.74395715
18FGFR41.64228202
19RIPK11.58912599
20DMPK1.47356627
21NUAK11.46433527
22FGFR31.45796729
23IRAK31.44836559
24TTN1.44719752
25EPHA31.44267070
26TGFBR21.43609022
27STK101.41937387
28NEK21.41423158
29CAMK1D1.37813556
30TXK1.36213935
31TAOK11.35043718
32MAP3K131.31963557
33CAMK1G1.31933233
34TYK21.30156233
35JAK11.28122812
36SIK11.26563227
37EPHB11.25415471
38ITK1.25286784
39ZAP701.24359293
40MAP2K31.23672883
41STK31.23644486
42SIK21.23196105
43PDGFRB1.18815242
44CDK61.17921725
45KIT1.17432040
46TAOK21.16819951
47BTK1.12395795
48PDGFRA1.11079572
49HIPK21.09711871
50MTOR1.09666456
51SIK31.09550084
52CHUK1.09364388
53CDC71.09086198
54MAP3K71.08314646
55ICK1.06839219
56IRAK21.06056766
57CDK41.05103944
58MAP3K61.02940891
59MAP3K21.01880528
60HCK1.01201367
61FES0.99732514
62CSF1R0.98839531
63PDPK10.96995335
64TBK10.96160063
65IKBKE0.95902739
66MAP3K110.95712923
67GRK60.95011864
68CDC42BPA0.94668732
69CDK90.93979470
70PIM10.93764320
71TNK20.93650208
72JAK20.93100698
73YES10.90444102
74FGR0.88679879
75TEC0.88561016
76IRAK10.82114138
77FLT30.81995658
78MAP3K140.79757232
79LRRK20.79231545
80RPS6KA40.77202390
81NLK0.76876436
82SYK0.76296594
83CSK0.76214214
84SCYL20.75211738
85RPS6KC10.74595443
86RPS6KL10.74595443
87ALK0.73995128
88MELK0.73879820
89NEK90.73180432
90MARK30.72032552
91LCK0.71969342
92RET0.71903231
93STK40.71353311
94WNK10.70734019
95SGK30.69765939
96TRPM70.69333898
97KSR10.66424143
98RPS6KA20.65911649
99MAPK110.65909017
100IKBKB0.65568678
101STK380.65076430
102PAK20.64683833
103TGFBR10.62438780
104MARK20.58494382
105MAPK120.58385029
106MAP3K30.58232534
107PRKCH0.58211544
108IRAK40.56439678
109PRKD20.55502048
110PASK0.54256482
111RPS6KA60.53785768
112LYN0.50977658
113BMX0.49619749
114PRKAA20.49320848
115CHEK10.46573674
116MATK0.46434016
117PAK40.45485447
118RAF10.44272396
119DYRK1B0.44146635
120CAMK40.43204856
121CLK10.43185729
122MAPKAPK20.41968789
123ABL10.41748114
124RPS6KA10.41022207
125PDK10.40564838
126EPHA20.39587892
127PRKAA10.39582061
128PTK20.39256009
129ARAF0.39016724
130PRKD10.38254472
131MAP3K10.36442487
132MAP3K80.35530833
133RPS6KB20.35473516
134FRK0.35130891
135ATR0.34959730

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052202.14846661
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.12888569
3B cell receptor signaling pathway_Homo sapiens_hsa046622.04842256
4Primary immunodeficiency_Homo sapiens_hsa053402.00241812
5Osteoclast differentiation_Homo sapiens_hsa043801.94284850
6Lysine degradation_Homo sapiens_hsa003101.86834083
7NF-kappa B signaling pathway_Homo sapiens_hsa040641.73110122
8Acute myeloid leukemia_Homo sapiens_hsa052211.68258690
9T cell receptor signaling pathway_Homo sapiens_hsa046601.67846033
10Leishmaniasis_Homo sapiens_hsa051401.59875250
11Pancreatic cancer_Homo sapiens_hsa052121.59720949
12Measles_Homo sapiens_hsa051621.51888893
13Toxoplasmosis_Homo sapiens_hsa051451.49564491
14Non-small cell lung cancer_Homo sapiens_hsa052231.48857126
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48175702
16Small cell lung cancer_Homo sapiens_hsa052221.44938264
17Prolactin signaling pathway_Homo sapiens_hsa049171.43976443
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.43227709
19Notch signaling pathway_Homo sapiens_hsa043301.42287634
20mTOR signaling pathway_Homo sapiens_hsa041501.42134818
21Other glycan degradation_Homo sapiens_hsa005111.40864716
22MicroRNAs in cancer_Homo sapiens_hsa052061.39232889
23Antigen processing and presentation_Homo sapiens_hsa046121.37907847
24Insulin resistance_Homo sapiens_hsa049311.35421419
25Hepatitis B_Homo sapiens_hsa051611.34442740
26Platelet activation_Homo sapiens_hsa046111.33821454
27Malaria_Homo sapiens_hsa051441.31982349
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.28255157
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.28008680
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25852301
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24104485
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18116616
33Herpes simplex infection_Homo sapiens_hsa051681.16736263
34Type II diabetes mellitus_Homo sapiens_hsa049301.16559419
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16378842
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.16170734
37Endometrial cancer_Homo sapiens_hsa052131.15070707
38HTLV-I infection_Homo sapiens_hsa051661.13422547
39Dorso-ventral axis formation_Homo sapiens_hsa043201.13075056
40TNF signaling pathway_Homo sapiens_hsa046681.12940657
41Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11206564
42Adherens junction_Homo sapiens_hsa045201.09816814
43Colorectal cancer_Homo sapiens_hsa052101.09479759
44Influenza A_Homo sapiens_hsa051641.08274063
45Chemokine signaling pathway_Homo sapiens_hsa040621.07777573
46Apoptosis_Homo sapiens_hsa042101.07455239
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07058384
48FoxO signaling pathway_Homo sapiens_hsa040681.06753763
49Viral carcinogenesis_Homo sapiens_hsa052031.05978120
50VEGF signaling pathway_Homo sapiens_hsa043701.05930977
51Neurotrophin signaling pathway_Homo sapiens_hsa047221.05844980
52Hematopoietic cell lineage_Homo sapiens_hsa046401.04944685
53Prostate cancer_Homo sapiens_hsa052151.04932443
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04866298
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04366260
56Intestinal immune network for IgA production_Homo sapiens_hsa046721.02030502
57Viral myocarditis_Homo sapiens_hsa054161.01470962
58Proteoglycans in cancer_Homo sapiens_hsa052050.99327780
59Focal adhesion_Homo sapiens_hsa045100.97592605
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96438474
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.96347097
62Glioma_Homo sapiens_hsa052140.96080223
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93108288
64Endocytosis_Homo sapiens_hsa041440.91117475
65GnRH signaling pathway_Homo sapiens_hsa049120.89546281
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.88573996
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87470775
68Renal cell carcinoma_Homo sapiens_hsa052110.87078651
69Salmonella infection_Homo sapiens_hsa051320.85189949
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83941336
71Insulin signaling pathway_Homo sapiens_hsa049100.83304153
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.83158017
73Tuberculosis_Homo sapiens_hsa051520.82694580
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.81597425
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81372759
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81070957
77Staphylococcus aureus infection_Homo sapiens_hsa051500.79054331
78Phagosome_Homo sapiens_hsa041450.77904473
79mRNA surveillance pathway_Homo sapiens_hsa030150.73704096
80AMPK signaling pathway_Homo sapiens_hsa041520.73691273
81African trypanosomiasis_Homo sapiens_hsa051430.71770913
82Hepatitis C_Homo sapiens_hsa051600.71224953
83Epstein-Barr virus infection_Homo sapiens_hsa051690.70252184
84Inositol phosphate metabolism_Homo sapiens_hsa005620.69483390
85Choline metabolism in cancer_Homo sapiens_hsa052310.68246711
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67758102
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67047906
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65610596
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.65531778
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64455695
91Estrogen signaling pathway_Homo sapiens_hsa049150.64227968
92MAPK signaling pathway_Homo sapiens_hsa040100.63965571
93Amoebiasis_Homo sapiens_hsa051460.63784029
94Cell cycle_Homo sapiens_hsa041100.61706037
95p53 signaling pathway_Homo sapiens_hsa041150.61689013
96Pathways in cancer_Homo sapiens_hsa052000.61471851
97HIF-1 signaling pathway_Homo sapiens_hsa040660.61318797
98Shigellosis_Homo sapiens_hsa051310.60043138
99ABC transporters_Homo sapiens_hsa020100.60002369
100Thyroid cancer_Homo sapiens_hsa052160.59326272
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59223111
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58679720
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.56619311
104Pentose phosphate pathway_Homo sapiens_hsa000300.56592039
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56444534
106ErbB signaling pathway_Homo sapiens_hsa040120.55546936
107Legionellosis_Homo sapiens_hsa051340.53516961
108Bladder cancer_Homo sapiens_hsa052190.53143476
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52354184
110Lysosome_Homo sapiens_hsa041420.52308500
111Glucagon signaling pathway_Homo sapiens_hsa049220.52037870
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51486794
113Pertussis_Homo sapiens_hsa051330.50691503
114Rap1 signaling pathway_Homo sapiens_hsa040150.50678548

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