UBLCP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.40026243
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.10017371
3protein neddylation (GO:0045116)4.91187002
4ATP synthesis coupled proton transport (GO:0015986)4.90395378
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.90395378
6chaperone-mediated protein transport (GO:0072321)4.77044442
7cullin deneddylation (GO:0010388)4.73216642
8establishment of integrated proviral latency (GO:0075713)4.62246580
9DNA double-strand break processing (GO:0000729)4.57590112
10DNA ligation (GO:0006266)4.55436741
11chromatin remodeling at centromere (GO:0031055)4.32199788
12CENP-A containing nucleosome assembly (GO:0034080)4.26972126
13protein deneddylation (GO:0000338)4.24412136
14respiratory electron transport chain (GO:0022904)4.16000814
15protein-cofactor linkage (GO:0018065)4.11030537
16platelet dense granule organization (GO:0060155)4.09982930
17electron transport chain (GO:0022900)4.05348554
18regulation of mitotic spindle checkpoint (GO:1903504)4.05336255
19regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.05336255
20DNA damage response, detection of DNA damage (GO:0042769)4.04105225
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.95925567
22negative regulation of DNA-dependent DNA replication (GO:2000104)3.88863908
23histone mRNA metabolic process (GO:0008334)3.79916398
24neuron cell-cell adhesion (GO:0007158)3.77118271
25histone exchange (GO:0043486)3.75767458
26establishment of viral latency (GO:0019043)3.74822706
27synaptic vesicle exocytosis (GO:0016079)3.73084208
28axon ensheathment in central nervous system (GO:0032291)3.65351337
29central nervous system myelination (GO:0022010)3.65351337
30organelle disassembly (GO:1903008)3.64856075
31presynaptic membrane organization (GO:0097090)3.59415659
32non-recombinational repair (GO:0000726)3.58645376
33double-strand break repair via nonhomologous end joining (GO:0006303)3.58645376
34fatty acid elongation (GO:0030497)3.57258162
35neuronal action potential propagation (GO:0019227)3.55935791
36nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.54310026
37exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.51314837
38single strand break repair (GO:0000012)3.45909347
39somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.44908705
40somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.44908705
41isotype switching (GO:0045190)3.44908705
42RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.40106400
43negative regulation of synaptic transmission, GABAergic (GO:0032229)3.39312882
44regulation of helicase activity (GO:0051095)3.38637625
45mitochondrial respiratory chain complex I assembly (GO:0032981)3.35604604
46NADH dehydrogenase complex assembly (GO:0010257)3.35604604
47mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35604604
48energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.34748478
49ATP hydrolysis coupled proton transport (GO:0015991)3.34748478
50attachment of spindle microtubules to kinetochore (GO:0008608)3.33614908
51mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.33568787
52DNA catabolic process, exonucleolytic (GO:0000738)3.32374739
53presynaptic membrane assembly (GO:0097105)3.30007559
54ribonucleoprotein complex disassembly (GO:0032988)3.26678659
55acrosome assembly (GO:0001675)3.25530624
56metaphase plate congression (GO:0051310)3.24018565
57negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.23522363
58negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.23522363
59negative regulation of mitotic sister chromatid segregation (GO:0033048)3.23522363
60negative regulation of mitotic sister chromatid separation (GO:2000816)3.23522363
61negative regulation of sister chromatid segregation (GO:0033046)3.23522363
62mitotic metaphase plate congression (GO:0007080)3.21560944
63spindle checkpoint (GO:0031577)3.21270611
64protein K11-linked ubiquitination (GO:0070979)3.21013803
65intra-S DNA damage checkpoint (GO:0031573)3.19754917
66purine nucleobase biosynthetic process (GO:0009113)3.19010302
67protein localization to kinetochore (GO:0034501)3.18673069
68neurotransmitter uptake (GO:0001504)3.18323464
69mitotic spindle checkpoint (GO:0071174)3.16540500
70response to X-ray (GO:0010165)3.15752826
71ribosome assembly (GO:0042255)3.15699358
72regulation of synaptic vesicle exocytosis (GO:2000300)3.15494697
73neural tube formation (GO:0001841)3.14972216
74protein complex biogenesis (GO:0070271)3.14305657
75spliceosomal snRNP assembly (GO:0000387)3.13378731
76maturation of 5.8S rRNA (GO:0000460)3.12322391
77DNA replication-independent nucleosome organization (GO:0034724)3.10817033
78DNA replication-independent nucleosome assembly (GO:0006336)3.10817033
79negative regulation of chromosome segregation (GO:0051985)3.08661905
80termination of RNA polymerase III transcription (GO:0006386)3.07054625
81transcription elongation from RNA polymerase III promoter (GO:0006385)3.07054625
82intraciliary transport (GO:0042073)3.05341413
83spindle assembly checkpoint (GO:0071173)3.04687578
84mitotic spindle assembly checkpoint (GO:0007094)3.03242383
85long-chain fatty acid biosynthetic process (GO:0042759)3.02348939
86negative regulation of DNA recombination (GO:0045910)3.02175789
87spermatid nucleus differentiation (GO:0007289)3.00896345
88establishment of chromosome localization (GO:0051303)2.96303257
89tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.94363453
90RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.94363453
91histone H2A acetylation (GO:0043968)2.93296227
92synaptic vesicle docking involved in exocytosis (GO:0016081)2.92702233
93glutamate secretion (GO:0014047)2.92504417
94regulation of protein glycosylation (GO:0060049)2.92485023
95anterograde synaptic vesicle transport (GO:0048490)2.90921400
96somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90439594
97somatic hypermutation of immunoglobulin genes (GO:0016446)2.90439594
98DNA replication checkpoint (GO:0000076)2.88408596
99substantia nigra development (GO:0021762)2.87622211
100negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.87416432
101regulation of cellular amino acid metabolic process (GO:0006521)2.86449301
102regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.85233353
103regulation of mitotic metaphase/anaphase transition (GO:0030071)2.85233353
104protein localization to synapse (GO:0035418)2.85187936
105regulation of short-term neuronal synaptic plasticity (GO:0048172)2.84915528
106transmission of nerve impulse (GO:0019226)2.84828311
107proteasome assembly (GO:0043248)2.84456426
108vocalization behavior (GO:0071625)2.83706302
109positive regulation of mitochondrial fission (GO:0090141)2.83279238
110regulation of DNA endoreduplication (GO:0032875)2.82384098
111negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.81713655
112transferrin transport (GO:0033572)2.81602659
113regulation of meiosis I (GO:0060631)2.81102634
114tricarboxylic acid cycle (GO:0006099)2.80731311
115synapsis (GO:0007129)2.80154614
116respiratory chain complex IV assembly (GO:0008535)2.79770708
117regulation of Golgi to plasma membrane protein transport (GO:0042996)2.79451376
118regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.78349367
119positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.77855820
120neurofilament cytoskeleton organization (GO:0060052)2.77776278
121mitotic G2/M transition checkpoint (GO:0044818)2.77556348
122regulation of mitotic sister chromatid segregation (GO:0033047)2.76373221
123regulation of sister chromatid segregation (GO:0033045)2.76373221
124regulation of mitotic sister chromatid separation (GO:0010965)2.76373221
125sequestering of actin monomers (GO:0042989)2.74865925
126transcription from mitochondrial promoter (GO:0006390)2.74613594
127termination of RNA polymerase II transcription (GO:0006369)2.74353716
128neuron-neuron synaptic transmission (GO:0007270)2.74272269
129neuron recognition (GO:0008038)2.74046031
130mitochondrial RNA metabolic process (GO:0000959)2.73582075
131response to insecticide (GO:0017085)2.72770974
132mitochondrial respiratory chain complex assembly (GO:0033108)2.71680819
133gamma-aminobutyric acid transport (GO:0015812)2.71168455
134ATP biosynthetic process (GO:0006754)2.70784928
135gamma-aminobutyric acid signaling pathway (GO:0007214)2.70158084
136trivalent inorganic cation transport (GO:0072512)2.69856079
137ferric iron transport (GO:0015682)2.69856079
138hydrogen ion transmembrane transport (GO:1902600)2.68894213
139neurotransmitter secretion (GO:0007269)2.65463702
140positive regulation of protein homodimerization activity (GO:0090073)2.64912162
141short-term memory (GO:0007614)2.64778325
142purine nucleoside triphosphate biosynthetic process (GO:0009145)2.64308605
143regulation of acyl-CoA biosynthetic process (GO:0050812)2.62227890
144purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.61978132
145negative regulation of dendrite morphogenesis (GO:0050774)2.61836273
146cell migration in hindbrain (GO:0021535)2.59944745
147NADH metabolic process (GO:0006734)2.58796412
148L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.57142145
149positive regulation of synapse assembly (GO:0051965)2.57021420
150anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.55845108
151regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.55836451
1527-methylguanosine mRNA capping (GO:0006370)2.52989928
153microtubule polymerization or depolymerization (GO:0031109)2.52370318
154regulation of synaptic vesicle transport (GO:1902803)2.51607931
155negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.51223192
156negative regulation of ligase activity (GO:0051352)2.51223192
157RNA capping (GO:0036260)2.50783106
1587-methylguanosine RNA capping (GO:0009452)2.50783106
159synaptic transmission, glutamatergic (GO:0035249)2.50645695
160establishment of mitochondrion localization (GO:0051654)2.50454285
161axonal fasciculation (GO:0007413)2.49221002
162regulation of coenzyme metabolic process (GO:0051196)2.48257038
163regulation of cofactor metabolic process (GO:0051193)2.48257038
164protein localization to mitochondrion (GO:0070585)2.48078911
165positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.47413538
166negative regulation of neurotransmitter transport (GO:0051589)2.47326220
167positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.46601794
168positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.46339501
169positive regulation of action potential (GO:0045760)2.46150567
170response to redox state (GO:0051775)2.46042015
171inner mitochondrial membrane organization (GO:0007007)2.45861733
172adult walking behavior (GO:0007628)2.42929792
173negative regulation of microtubule polymerization (GO:0031115)2.42582410
174neurotransmitter transport (GO:0006836)2.41167539
175proton transport (GO:0015992)2.41141443
176regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.40803662
177cerebellar granule cell differentiation (GO:0021707)2.40435324
178DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.37993225
179membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.37467112
180hydrogen transport (GO:0006818)2.37436877

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.75699328
2GBX2_23144817_ChIP-Seq_PC3_Human3.38053521
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.11042704
4* ELK1_19687146_ChIP-ChIP_HELA_Human2.97496684
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.67449646
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.54981223
7TAF15_26573619_Chip-Seq_HEK293_Human2.46775680
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.39587759
9PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30123117
10VDR_23849224_ChIP-Seq_CD4+_Human2.23305802
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18593102
12VDR_22108803_ChIP-Seq_LS180_Human2.17506268
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.11961570
14E2F7_22180533_ChIP-Seq_HELA_Human2.07245135
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07093638
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02970156
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97373130
18* GABP_17652178_ChIP-ChIP_JURKAT_Human1.97009641
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.95618081
20FUS_26573619_Chip-Seq_HEK293_Human1.95351631
21ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93076309
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90633777
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90594142
24* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90470678
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90175653
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.87065713
27P300_19829295_ChIP-Seq_ESCs_Human1.84054744
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82335632
29* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.81021743
30FOXP3_21729870_ChIP-Seq_TREG_Human1.79487479
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.77937312
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.77687236
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75714735
34AR_21572438_ChIP-Seq_LNCaP_Human1.74756638
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70530206
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.68471153
37EWS_26573619_Chip-Seq_HEK293_Human1.67335637
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65745747
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65025151
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.62171214
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.59063200
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58726777
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58726777
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58418208
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.57431578
46REST_21632747_ChIP-Seq_MESCs_Mouse1.56844691
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.56200128
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.53759219
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52405330
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.50441603
51FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.49929904
52MYC_18940864_ChIP-ChIP_HL60_Human1.48002112
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.47020882
54SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45528313
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45439972
56ER_23166858_ChIP-Seq_MCF-7_Human1.44055126
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43941312
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43741826
59JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41743983
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40808526
61RNF2_27304074_Chip-Seq_NSC_Mouse1.40272788
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.40039780
63SMAD4_21799915_ChIP-Seq_A2780_Human1.39837410
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.39783062
65* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39507913
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37772066
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.36928962
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35178022
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32098411
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31593975
71DCP1A_22483619_ChIP-Seq_HELA_Human1.31521707
72* REST_18959480_ChIP-ChIP_MESCs_Mouse1.30705995
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27537873
74CBP_20019798_ChIP-Seq_JUKART_Human1.27537873
75NELFA_20434984_ChIP-Seq_ESCs_Mouse1.25200800
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.24671242
77FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24484449
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.23487589
79* GABP_19822575_ChIP-Seq_HepG2_Human1.22621017
80CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22185867
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21552847
82MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21312424
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20977112
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20887030
85HTT_18923047_ChIP-ChIP_STHdh_Human1.19168149
86JUN_21703547_ChIP-Seq_K562_Human1.18391850
87ZNF274_21170338_ChIP-Seq_K562_Hela1.18307480
88HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18175809
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.17520873
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16204164
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15283413
92CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.15091668
93IRF1_19129219_ChIP-ChIP_H3396_Human1.14751635
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14083907
95SOX9_26525672_Chip-Seq_HEART_Mouse1.13780749
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13229195
97FLI1_27457419_Chip-Seq_LIVER_Mouse1.13005997
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12649937
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12610706
100E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12458432
101MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12028665
102CRX_20693478_ChIP-Seq_RETINA_Mouse1.10772575
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10527854
104ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10122214
105PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09121099
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09007248
107AR_25329375_ChIP-Seq_VCAP_Human1.08573781
108P53_22387025_ChIP-Seq_ESCs_Mouse1.08544404
109SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07661555
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06677906
111TTF2_22483619_ChIP-Seq_HELA_Human1.05621021
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05488034
113P300_18555785_Chip-Seq_ESCs_Mouse1.03751076
114NOTCH1_21737748_ChIP-Seq_TLL_Human1.03501003
115NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03114205
116* ELK1_22589737_ChIP-Seq_MCF10A_Human1.03106070
117NANOG_16153702_ChIP-ChIP_HESCs_Human1.02628360
118REST_19997604_ChIP-ChIP_NEURONS_Mouse1.01181596
119STAT3_23295773_ChIP-Seq_U87_Human1.01142384
120CMYC_18555785_Chip-Seq_ESCs_Mouse1.00663475
121SOX2_21211035_ChIP-Seq_LN229_Gbm1.00537951
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00529965
123IGF1R_20145208_ChIP-Seq_DFB_Human1.00279814
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99553702
125SOX2_16153702_ChIP-ChIP_HESCs_Human0.98249684
126SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97867449
127MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97833815
128SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97551751
129EZH2_27294783_Chip-Seq_ESCs_Mouse0.97457035
130SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96842020
131SRF_21415370_ChIP-Seq_HL-1_Mouse0.96294757
132E2F1_18555785_Chip-Seq_ESCs_Mouse0.96290639
133MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95706303
134RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94860017
135POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94716646
136NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93582009
137NMYC_18555785_Chip-Seq_ESCs_Mouse0.93241690
138HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92921010
139ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92825735
140STAT3_18555785_Chip-Seq_ESCs_Mouse0.92584855
141PRDM14_20953172_ChIP-Seq_ESCs_Human0.91995113
142PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91903666
143NANOG_19829295_ChIP-Seq_ESCs_Human0.91896350
144SOX2_19829295_ChIP-Seq_ESCs_Human0.91896350
145RUNX2_22187159_ChIP-Seq_PCA_Human0.91554921
146KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91453543
147SALL1_21062744_ChIP-ChIP_HESCs_Human0.91304490
148RNF2_27304074_Chip-Seq_ESCs_Mouse0.91110460
149EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90639254

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.23372983
2MP0008058_abnormal_DNA_repair4.79928426
3MP0010094_abnormal_chromosome_stability3.50975588
4MP0004859_abnormal_synaptic_plasticity3.08743708
5MP0004270_analgesia2.98785726
6MP0002102_abnormal_ear_morphology2.82060441
7MP0009046_muscle_twitch2.71788699
8MP0001968_abnormal_touch/_nociception2.68790253
9MP0001529_abnormal_vocalization2.68621741
10MP0003890_abnormal_embryonic-extraembry2.66048686
11MP0002735_abnormal_chemical_nociception2.50871339
12MP0003635_abnormal_synaptic_transmissio2.49596772
13MP0002064_seizures2.47526047
14MP0002736_abnormal_nociception_after2.45207373
15MP0006054_spinal_hemorrhage2.43065596
16MP0002734_abnormal_mechanical_nocicepti2.42422170
17MP0002272_abnormal_nervous_system2.40007730
18MP0009745_abnormal_behavioral_response2.33882910
19MP0006276_abnormal_autonomic_nervous2.31818981
20MP0008057_abnormal_DNA_replication2.31289378
21MP0003186_abnormal_redox_activity2.24901205
22MP0004957_abnormal_blastocyst_morpholog2.13649934
23MP0003693_abnormal_embryo_hatching2.11925096
24MP0001440_abnormal_grooming_behavior2.11898230
25MP0003718_maternal_effect2.10018275
26MP0003786_premature_aging2.07419479
27MP0005423_abnormal_somatic_nervous2.01486753
28MP0004133_heterotaxia2.00347591
29MP0002063_abnormal_learning/memory/cond2.00342015
30MP0001293_anophthalmia1.98790199
31MP0003122_maternal_imprinting1.98160034
32MP0001486_abnormal_startle_reflex1.92925386
33MP0004142_abnormal_muscle_tone1.92360426
34MP0002572_abnormal_emotion/affect_behav1.91580151
35MP0000778_abnormal_nervous_system1.90757078
36MP0006292_abnormal_olfactory_placode1.88972352
37MP0001905_abnormal_dopamine_level1.87593666
38MP0002067_abnormal_sensory_capabilities1.80784774
39MP0003077_abnormal_cell_cycle1.78953501
40MP0005084_abnormal_gallbladder_morpholo1.76893890
41MP0001984_abnormal_olfaction1.74462795
42MP0003567_abnormal_fetal_cardiomyocyte1.72906176
43MP0004147_increased_porphyrin_level1.71025067
44MP0008007_abnormal_cellular_replicative1.70144756
45MP0003123_paternal_imprinting1.68939584
46MP0008877_abnormal_DNA_methylation1.67708074
47MP0000569_abnormal_digit_pigmentation1.66079838
48MP0005253_abnormal_eye_physiology1.62785998
49MP0002837_dystrophic_cardiac_calcinosis1.60701970
50MP0002254_reproductive_system_inflammat1.60401083
51MP0008260_abnormal_autophagy1.59215497
52MP0003111_abnormal_nucleus_morphology1.55296701
53MP0002184_abnormal_innervation1.54157776
54MP0003941_abnormal_skin_development1.53576041
55MP0001970_abnormal_pain_threshold1.48189399
56MP0002733_abnormal_thermal_nociception1.47703470
57MP0001501_abnormal_sleep_pattern1.47565092
58MP0002234_abnormal_pharynx_morphology1.45621852
59MP0003806_abnormal_nucleotide_metabolis1.42501050
60MP0005171_absent_coat_pigmentation1.41850187
61MP0004742_abnormal_vestibular_system1.41341917
62MP0003787_abnormal_imprinting1.37116820
63MP0000372_irregular_coat_pigmentation1.36689063
64MP0005499_abnormal_olfactory_system1.33815865
65MP0005394_taste/olfaction_phenotype1.33815865
66MP0002233_abnormal_nose_morphology1.30675498
67MP0002938_white_spotting1.30234285
68MP0003121_genomic_imprinting1.29906555
69MP0004924_abnormal_behavior1.28967108
70MP0005386_behavior/neurological_phenoty1.28967108
71MP0000647_abnormal_sebaceous_gland1.28603558
72MP0002653_abnormal_ependyma_morphology1.26993763
73MP0008789_abnormal_olfactory_epithelium1.24366661
74MP0002882_abnormal_neuron_morphology1.24158872
75MP0003136_yellow_coat_color1.24059908
76MP0000955_abnormal_spinal_cord1.22748280
77MP0004215_abnormal_myocardial_fiber1.21912857
78MP0002066_abnormal_motor_capabilities/c1.20620310
79MP0008995_early_reproductive_senescence1.19948311
80MP0003950_abnormal_plasma_membrane1.19741711
81MP0003119_abnormal_digestive_system1.18808892
82MP0006035_abnormal_mitochondrial_morpho1.16128742
83MP0008569_lethality_at_weaning1.15663631
84MP0001929_abnormal_gametogenesis1.14249821
85MP0002090_abnormal_vision1.13328129
86MP0003937_abnormal_limbs/digits/tail_de1.13054658
87MP0005551_abnormal_eye_electrophysiolog1.12888513
88MP0002876_abnormal_thyroid_physiology1.10965483
89MP0001286_abnormal_eye_development1.09784997
90MP0003632_abnormal_nervous_system1.07091055
91MP0002752_abnormal_somatic_nervous1.06806724
92MP0003329_amyloid_beta_deposits1.06723721
93MP0003221_abnormal_cardiomyocyte_apopto1.06486266
94MP0002332_abnormal_exercise_endurance1.05793407
95MP0009697_abnormal_copulation1.05594872
96MP0009384_cardiac_valve_regurgitation1.05367408
97MP0000427_abnormal_hair_cycle1.02232119
98MP0001188_hyperpigmentation1.02124119
99MP0002210_abnormal_sex_determination1.02027712
100MP0004811_abnormal_neuron_physiology1.01754042
101MP0002229_neurodegeneration1.01424279
102MP0010386_abnormal_urinary_bladder1.00609372
103MP0000358_abnormal_cell_content/1.00592246
104MP0004145_abnormal_muscle_electrophysio1.00498725
105MP0000920_abnormal_myelination0.99072510
106MP0001177_atelectasis0.97688493
107MP0002557_abnormal_social/conspecific_i0.97518277
108MP0005391_vision/eye_phenotype0.96780251
109MP0002152_abnormal_brain_morphology0.96347842
110MP0001963_abnormal_hearing_physiology0.96171811
111MP0001764_abnormal_homeostasis0.95913424
112MP0001485_abnormal_pinna_reflex0.92482307
113MP0006036_abnormal_mitochondrial_physio0.91185280
114MP0002638_abnormal_pupillary_reflex0.89343758
115MP0004197_abnormal_fetal_growth/weight/0.87617299
116MP0005646_abnormal_pituitary_gland0.87560488
117MP0001542_abnormal_bone_strength0.87511110
118MP0002084_abnormal_developmental_patter0.86871405
119MP0001324_abnormal_eye_pigmentation0.86840384
120MP0003011_delayed_dark_adaptation0.86770950
121MP0000049_abnormal_middle_ear0.86640280
122MP0003631_nervous_system_phenotype0.86606137
123MP0000653_abnormal_sex_gland0.85910159
124MP0001119_abnormal_female_reproductive0.85716545
125MP0002095_abnormal_skin_pigmentation0.85291576
126MP0000749_muscle_degeneration0.85270775
127MP0002277_abnormal_respiratory_mucosa0.84825625
128MP0006072_abnormal_retinal_apoptosis0.84634598
129MP0005195_abnormal_posterior_eye0.83910810
130MP0000026_abnormal_inner_ear0.83889465
131MP0001145_abnormal_male_reproductive0.83075005
132MP0003656_abnormal_erythrocyte_physiolo0.82975488
133MP0002751_abnormal_autonomic_nervous0.82811711
134MP0004085_abnormal_heartbeat0.82599559
135MP0004036_abnormal_muscle_relaxation0.81945046
136MP0009780_abnormal_chondrocyte_physiolo0.81201016
137MP0001697_abnormal_embryo_size0.80941611
138MP0005075_abnormal_melanosome_morpholog0.79401672
139MP0001299_abnormal_eye_distance/0.77920469
140MP0001986_abnormal_taste_sensitivity0.76932302
141MP0000013_abnormal_adipose_tissue0.76255319
142MP0008872_abnormal_physiological_respon0.76062897
143MP0005248_abnormal_Harderian_gland0.74628190
144MP0002822_catalepsy0.73977887
145MP0004043_abnormal_pH_regulation0.72975870
146MP0003634_abnormal_glial_cell0.72417853
147MP0005503_abnormal_tendon_morphology0.72318128
148MP0005174_abnormal_tail_pigmentation0.72234742
149MP0003698_abnormal_male_reproductive0.71405093
150MP0008932_abnormal_embryonic_tissue0.70650046
151MP0002160_abnormal_reproductive_system0.70357190
152MP0005645_abnormal_hypothalamus_physiol0.70265469
153MP0002085_abnormal_embryonic_tissue0.69654169
154MP0002972_abnormal_cardiac_muscle0.69429208
155MP0000751_myopathy0.67933791
156MP0001730_embryonic_growth_arrest0.67494318
157MP0009765_abnormal_xenobiotic_induced0.66575826
158MP0008873_increased_physiological_sensi0.66393130
159MP0004858_abnormal_nervous_system0.65898595
160MP0005620_abnormal_muscle_contractility0.65492494
161MP0003755_abnormal_palate_morphology0.65457877
162MP0003861_abnormal_nervous_system0.65420261
163MP0000350_abnormal_cell_proliferation0.64000917
164MP0000631_abnormal_neuroendocrine_gland0.63773712
165MP0000313_abnormal_cell_death0.62932854
166MP0005410_abnormal_fertilization0.61339253
167MP0005389_reproductive_system_phenotype0.59447488

Predicted human phenotypes

RankGene SetZ-score
1Increased serum pyruvate (HP:0003542)5.36905340
2Abnormality of glycolysis (HP:0004366)5.36905340
3Acute necrotizing encephalopathy (HP:0006965)5.34454593
4Focal motor seizures (HP:0011153)5.18938987
5Abnormal mitochondria in muscle tissue (HP:0008316)4.82969059
6Progressive macrocephaly (HP:0004481)4.64076985
7Acute encephalopathy (HP:0006846)4.36653310
8Myokymia (HP:0002411)4.06713977
9Mitochondrial inheritance (HP:0001427)4.04404172
10Atonic seizures (HP:0010819)3.99540918
11Neuroendocrine neoplasm (HP:0100634)3.90052303
12Increased CSF lactate (HP:0002490)3.71312920
13Pheochromocytoma (HP:0002666)3.70771094
14Retinal dysplasia (HP:0007973)3.62392507
15Leukodystrophy (HP:0002415)3.37577784
16Type II lissencephaly (HP:0007260)3.36175266
17Hepatocellular necrosis (HP:0001404)3.17559448
18Epileptic encephalopathy (HP:0200134)3.14553899
19Molar tooth sign on MRI (HP:0002419)3.02187240
20Abnormality of midbrain morphology (HP:0002418)3.02187240
21Focal seizures (HP:0007359)3.00811199
22Febrile seizures (HP:0002373)3.00013724
23Pancreatic fibrosis (HP:0100732)2.99330213
24Optic disc pallor (HP:0000543)2.99019804
25Cerebral edema (HP:0002181)2.98262228
26Pancreatic cysts (HP:0001737)2.94163735
27Cerebral hypomyelination (HP:0006808)2.91551690
28Abnormality of chromosome stability (HP:0003220)2.89163342
29Hyperventilation (HP:0002883)2.84971189
30True hermaphroditism (HP:0010459)2.83937708
31Abnormality of the labia minora (HP:0012880)2.81688261
32Severe combined immunodeficiency (HP:0004430)2.79345070
33Absence seizures (HP:0002121)2.73959670
34Progressive cerebellar ataxia (HP:0002073)2.69763463
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.66441948
36Abnormality of alanine metabolism (HP:0010916)2.66441948
37Hyperalaninemia (HP:0003348)2.66441948
38Colon cancer (HP:0003003)2.66025301
39Degeneration of the lateral corticospinal tracts (HP:0002314)2.62859265
40Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.62859265
41Combined immunodeficiency (HP:0005387)2.59578685
42Respiratory failure (HP:0002878)2.55349501
43Abnormal hair whorl (HP:0010721)2.53541786
44Dialeptic seizures (HP:0011146)2.53212127
45Sensory axonal neuropathy (HP:0003390)2.52743009
46Generalized tonic-clonic seizures (HP:0002069)2.47512025
47Lactic acidosis (HP:0003128)2.44425534
48Median cleft lip (HP:0000161)2.44040629
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.41479760
50Hepatic necrosis (HP:0002605)2.40717698
51Degeneration of anterior horn cells (HP:0002398)2.40566029
52Abnormality of the anterior horn cell (HP:0006802)2.40566029
53Meckel diverticulum (HP:0002245)2.39383129
54Aplasia/Hypoplasia of the fovea (HP:0008060)2.38603962
55Hypoplasia of the fovea (HP:0007750)2.38603962
56Autoamputation (HP:0001218)2.38157204
57Calf muscle hypertrophy (HP:0008981)2.34557009
58Abnormality of the ileum (HP:0001549)2.32483888
59Volvulus (HP:0002580)2.31264132
60Abnormality of the fovea (HP:0000493)2.31136034
61Exercise intolerance (HP:0003546)2.28700543
62Termporal pattern (HP:0011008)2.26447491
63Insidious onset (HP:0003587)2.26447491
64Metaphyseal dysplasia (HP:0100255)2.24298033
65Increased serum lactate (HP:0002151)2.24052257
66Bifid tongue (HP:0010297)2.23780075
67Hypoplasia of the capital femoral epiphysis (HP:0003090)2.23577908
68Thyroiditis (HP:0100646)2.23237508
69X-linked dominant inheritance (HP:0001423)2.22534318
70Intestinal atresia (HP:0011100)2.21609432
71Gait imbalance (HP:0002141)2.21379006
72Atrophy/Degeneration involving motor neurons (HP:0007373)2.20182298
73Aplasia/Hypoplasia of the tibia (HP:0005772)2.15084190
74Hyperglycinemia (HP:0002154)2.14918724
75Abnormality of serum amino acid levels (HP:0003112)2.13162103
76Progressive inability to walk (HP:0002505)2.12222111
77Abnormality of the corticospinal tract (HP:0002492)2.11835020
78Delusions (HP:0000746)2.10972396
79Medial flaring of the eyebrow (HP:0010747)2.10490920
80Broad foot (HP:0001769)2.09728988
81Aplasia/Hypoplasia of the tongue (HP:0010295)2.09712073
82Sloping forehead (HP:0000340)2.09445432
83Congenital primary aphakia (HP:0007707)2.09282002
84Abolished electroretinogram (ERG) (HP:0000550)2.07778799
85Genital tract atresia (HP:0001827)2.06965246
86Vaginal atresia (HP:0000148)2.04710359
87Increased hepatocellular lipid droplets (HP:0006565)2.02225565
88Congenital stationary night blindness (HP:0007642)2.01077698
89Nephrogenic diabetes insipidus (HP:0009806)1.98221811
90Abnormality of the preputium (HP:0100587)1.96975192
91Chronic hepatic failure (HP:0100626)1.95964328
92Duodenal stenosis (HP:0100867)1.94560805
93Small intestinal stenosis (HP:0012848)1.94560805
94Nephronophthisis (HP:0000090)1.94453674
95Absent epiphyses (HP:0010577)1.94293303
96Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.94293303
97Renal cortical cysts (HP:0000803)1.94061601
98Anencephaly (HP:0002323)1.93129236
99Type I transferrin isoform profile (HP:0003642)1.92626385
100Abnormality of B cell number (HP:0010975)1.92618375
101B lymphocytopenia (HP:0010976)1.92111551
102Muscle hypertrophy of the lower extremities (HP:0008968)1.91181335
103Unsteady gait (HP:0002317)1.90368348
104Abnormality of the duodenum (HP:0002246)1.90174094
105Broad-based gait (HP:0002136)1.88716730
106Narrow forehead (HP:0000341)1.88715013
107Posterior subcapsular cataract (HP:0007787)1.87507564
108Agnosia (HP:0010524)1.86621899
109Limb dystonia (HP:0002451)1.86487625
110Amyotrophic lateral sclerosis (HP:0007354)1.86223933
111Delayed gross motor development (HP:0002194)1.85868697
112Methylmalonic acidemia (HP:0002912)1.85863891
113Postaxial hand polydactyly (HP:0001162)1.85775215
114Emotional lability (HP:0000712)1.85044982
115Abnormal lung lobation (HP:0002101)1.84522923
116Astigmatism (HP:0000483)1.83538870
117Dandy-Walker malformation (HP:0001305)1.83133005
118Cerebral hemorrhage (HP:0001342)1.81225892
1193-Methylglutaconic aciduria (HP:0003535)1.80659487
120Adrenal hypoplasia (HP:0000835)1.80311289
121CNS demyelination (HP:0007305)1.79983784
122Cortical dysplasia (HP:0002539)1.79938535
123Stenosis of the external auditory canal (HP:0000402)1.79568198
124Dysdiadochokinesis (HP:0002075)1.79325307
125Medulloblastoma (HP:0002885)1.78019100
126CNS hypomyelination (HP:0003429)1.78008500
127Sclerocornea (HP:0000647)1.77750966
128Postnatal microcephaly (HP:0005484)1.77627547
129Preaxial hand polydactyly (HP:0001177)1.77402994
130Abnormality of the pons (HP:0007361)1.76745161
131Decreased testicular size (HP:0008734)1.76713087
132Gaze-evoked nystagmus (HP:0000640)1.76609820
133Abnormality of macular pigmentation (HP:0008002)1.76483664
134Lipid accumulation in hepatocytes (HP:0006561)1.76421574
135Lethargy (HP:0001254)1.76321045
136Abnormality of aspartate family amino acid metabolism (HP:0010899)1.75676248
137Irregular epiphyses (HP:0010582)1.74761372
138Renal Fanconi syndrome (HP:0001994)1.73332794
139Scanning speech (HP:0002168)1.71889824
140Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.70464921
141Anxiety (HP:0000739)1.68199926
142Hypothermia (HP:0002045)1.67340072
143Amblyopia (HP:0000646)1.67212552
144Parakeratosis (HP:0001036)1.67169977
145Truncal ataxia (HP:0002078)1.65013633
146Short tibia (HP:0005736)1.64118104
147Poor coordination (HP:0002370)1.63072074
148Epileptiform EEG discharges (HP:0011182)1.62950485
149Neoplasm of the peripheral nervous system (HP:0100007)1.62035547
150Methylmalonic aciduria (HP:0012120)1.61801663
151Ulnar claw (HP:0001178)1.61292172
152Specific learning disability (HP:0001328)1.59604753
153Esotropia (HP:0000565)1.58450742
154Abnormal gallbladder physiology (HP:0012438)1.55920301
155Cholecystitis (HP:0001082)1.55920301
156Dysmetria (HP:0001310)1.55094222
157Spastic gait (HP:0002064)1.54631429
158Impaired vibration sensation in the lower limbs (HP:0002166)1.53021545
159Myotonia (HP:0002486)1.52616467
160Action tremor (HP:0002345)1.52263408
161Abnormal eating behavior (HP:0100738)1.52224908
162Abnormality of pain sensation (HP:0010832)1.51372307
163Impaired pain sensation (HP:0007328)1.51372307
164Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.51135247
165Decreased activity of mitochondrial respiratory chain (HP:0008972)1.51135247

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.90621145
2TRIM283.69218298
3PNCK2.78264065
4MAP3K42.61723250
5NTRK32.48999113
6EPHA42.37023940
7EIF2AK12.32751679
8PLK22.31546018
9SRPK12.29096075
10BCR2.26887545
11OXSR12.26098060
12MAP2K72.24397438
13BUB12.23138954
14MAP3K122.14878695
15STK392.10771814
16MKNK12.03306177
17PBK1.99118835
18MAP4K21.99108809
19MKNK21.94378107
20ARAF1.86715297
21TTK1.81358413
22CCNB11.80377791
23PINK11.80310891
24MST41.76970406
25TNIK1.75801326
26AKT31.74935615
27MINK11.72718588
28TSSK61.70560067
29NEK61.67564930
30DYRK31.67528414
31PDK21.55679364
32LIMK11.45323022
33WEE11.44509710
34MAP3K91.43479638
35MAP2K41.43054352
36VRK21.40656354
37PLK31.40476011
38CDK191.37426693
39BRAF1.32325446
40PRPF4B1.27081856
41ACVR1B1.25036823
42GRK51.23000467
43PASK1.21303636
44NEK11.17785342
45STK38L1.14732998
46PDK41.11968979
47PDK31.11968979
48NME11.10433953
49RPS6KA41.08706271
50PRKCG1.08387430
51LATS21.06993652
52MYLK1.06563698
53SGK4941.05375837
54SGK2231.05375837
55EIF2AK21.04642470
56CDK181.04197695
57CDK141.02523372
58CAMKK20.99300218
59STK160.96478927
60FER0.96389336
61TXK0.96373133
62CDK150.96328686
63KSR10.95531561
64BMPR20.95076602
65GRK70.94908489
66CAMK2B0.94002865
67WNK40.93777009
68MARK10.92907028
69ADRBK20.90295082
70MAPK130.89613791
71PAK30.88058838
72WNK10.86897663
73CSNK1G30.85337652
74GRK10.84808120
75DYRK20.84236816
76CDK11A0.82115342
77CAMK2A0.81130191
78DAPK20.80616377
79PRKCE0.77335791
80ATR0.76654602
81ERBB40.76245291
82NTRK10.75384979
83PAK60.74321539
84ROCK20.73696273
85CDK50.73211032
86CSNK1G20.72812476
87PLK40.72297088
88TAF10.71516890
89STK30.71170103
90FRK0.70775641
91DAPK10.70097355
92TEC0.69882580
93AURKA0.68262976
94EIF2AK30.67913479
95BRSK10.67531585
96CAMK2G0.66350103
97PHKG10.64746648
98PHKG20.64746648
99TGFBR10.60957060
100SIK30.60120418
101VRK10.58450067
102CHEK20.57676847
103BRSK20.57654925
104MUSK0.57065554
105ATM0.55023172
106UHMK10.54783614
107AURKB0.54748119
108FGR0.53961490
109WNK30.53241840
110SGK20.53185662
111PKN10.52684482
112BMPR1B0.51772653
113ADRBK10.51291733
114BRD40.49851384
115CSNK2A10.48715377
116CAMK2D0.48181982
117MET0.48153535
118DYRK1A0.47793963
119CDC70.47420044
120CSNK1A1L0.46841225
121FGFR10.45552331
122PTK2B0.44845835
123PRKCI0.44804941
124FLT30.44682510
125ERBB30.44655274
126CDK80.44557309
127MAP2K10.44016008
128CSNK1G10.43944464
129BCKDK0.43788453
130PRKACA0.43021891
131MARK30.41963742
132PLK10.41904200
133CDK30.41803851
134OBSCN0.41322854
135CSNK2A20.41224816
136NUAK10.41061603
137STK240.39767329
138ZAK0.38707183
139EGFR0.31937830
140CHEK10.31189550
141NLK0.30969503
142NEK90.30019895
143PRKACB0.29415711

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.51592215
2Non-homologous end-joining_Homo sapiens_hsa034504.03098362
3Parkinsons disease_Homo sapiens_hsa050123.75572306
4Proteasome_Homo sapiens_hsa030503.66899126
5Collecting duct acid secretion_Homo sapiens_hsa049662.84531996
6Alzheimers disease_Homo sapiens_hsa050102.81877925
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.80344036
8Synaptic vesicle cycle_Homo sapiens_hsa047212.79456421
9Huntingtons disease_Homo sapiens_hsa050162.69162934
10Nicotine addiction_Homo sapiens_hsa050332.65740756
11Homologous recombination_Homo sapiens_hsa034402.49978766
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.44038403
13Spliceosome_Homo sapiens_hsa030402.26398818
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26312615
15RNA degradation_Homo sapiens_hsa030182.17209918
16Fanconi anemia pathway_Homo sapiens_hsa034601.97876997
17Cardiac muscle contraction_Homo sapiens_hsa042601.95774463
18DNA replication_Homo sapiens_hsa030301.93931564
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.91194298
20Pyruvate metabolism_Homo sapiens_hsa006201.87689529
21Base excision repair_Homo sapiens_hsa034101.77463727
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.71381023
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.61324150
24Vibrio cholerae infection_Homo sapiens_hsa051101.60993483
25Cell cycle_Homo sapiens_hsa041101.58206275
26GABAergic synapse_Homo sapiens_hsa047271.54872157
27RNA polymerase_Homo sapiens_hsa030201.54104662
28Fatty acid elongation_Homo sapiens_hsa000621.53761456
29mRNA surveillance pathway_Homo sapiens_hsa030151.51872276
30Vitamin B6 metabolism_Homo sapiens_hsa007501.47792906
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46804087
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.32449270
33Ribosome_Homo sapiens_hsa030101.28366987
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25800982
35Butanoate metabolism_Homo sapiens_hsa006501.21838186
36Steroid biosynthesis_Homo sapiens_hsa001001.20429365
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19344664
38Morphine addiction_Homo sapiens_hsa050321.17476713
39Propanoate metabolism_Homo sapiens_hsa006401.15982440
40Serotonergic synapse_Homo sapiens_hsa047261.15085799
41One carbon pool by folate_Homo sapiens_hsa006701.14603816
42Dopaminergic synapse_Homo sapiens_hsa047281.12215337
43Glutamatergic synapse_Homo sapiens_hsa047241.12087852
44Long-term potentiation_Homo sapiens_hsa047201.11087622
45Olfactory transduction_Homo sapiens_hsa047401.09159215
46Amphetamine addiction_Homo sapiens_hsa050311.07515286
47Sulfur metabolism_Homo sapiens_hsa009201.07165014
48Taste transduction_Homo sapiens_hsa047421.05798039
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.04671474
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04429818
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04149933
52Circadian entrainment_Homo sapiens_hsa047131.02227101
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00848842
54Oocyte meiosis_Homo sapiens_hsa041140.97768737
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.96535501
56Regulation of autophagy_Homo sapiens_hsa041400.96235793
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95864478
58Basal transcription factors_Homo sapiens_hsa030220.95132311
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93984729
60Phototransduction_Homo sapiens_hsa047440.93645161
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92266854
62Long-term depression_Homo sapiens_hsa047300.90329560
63Ether lipid metabolism_Homo sapiens_hsa005650.87492953
64p53 signaling pathway_Homo sapiens_hsa041150.85843203
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84525790
66Axon guidance_Homo sapiens_hsa043600.83209758
67Folate biosynthesis_Homo sapiens_hsa007900.82857962
68Carbon metabolism_Homo sapiens_hsa012000.79215422
69Tyrosine metabolism_Homo sapiens_hsa003500.78798094
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.76245192
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75654759
72Protein export_Homo sapiens_hsa030600.75346419
73Salivary secretion_Homo sapiens_hsa049700.74290341
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71245411
75Metabolic pathways_Homo sapiens_hsa011000.67999621
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66473713
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65929182
78Gap junction_Homo sapiens_hsa045400.64399079
79Selenocompound metabolism_Homo sapiens_hsa004500.63413892
80Rheumatoid arthritis_Homo sapiens_hsa053230.62789925
81Legionellosis_Homo sapiens_hsa051340.59345991
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58363975
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58278417
84Nucleotide excision repair_Homo sapiens_hsa034200.58093087
85Phenylalanine metabolism_Homo sapiens_hsa003600.58069000
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57463119
87RNA transport_Homo sapiens_hsa030130.57416633
88Calcium signaling pathway_Homo sapiens_hsa040200.55697584
89Caffeine metabolism_Homo sapiens_hsa002320.55422843
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55164805
91Asthma_Homo sapiens_hsa053100.53749541
92Gastric acid secretion_Homo sapiens_hsa049710.53708062
93Renin secretion_Homo sapiens_hsa049240.53526397
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52738908
95Primary immunodeficiency_Homo sapiens_hsa053400.51773836
96Phagosome_Homo sapiens_hsa041450.51281562
97Purine metabolism_Homo sapiens_hsa002300.51019358
98Arginine and proline metabolism_Homo sapiens_hsa003300.50201480
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45498011
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43835956
101Glutathione metabolism_Homo sapiens_hsa004800.42992771
102Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42714231
103Cholinergic synapse_Homo sapiens_hsa047250.42480490
104Oxytocin signaling pathway_Homo sapiens_hsa049210.41008631
105Biosynthesis of amino acids_Homo sapiens_hsa012300.40793748
106Insulin secretion_Homo sapiens_hsa049110.40721345
107Epstein-Barr virus infection_Homo sapiens_hsa051690.40365747
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39360520
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37514427
110TGF-beta signaling pathway_Homo sapiens_hsa043500.36176626
111Cocaine addiction_Homo sapiens_hsa050300.35748968
112Mismatch repair_Homo sapiens_hsa034300.35649464
113Hedgehog signaling pathway_Homo sapiens_hsa043400.34430784
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34329177
115Circadian rhythm_Homo sapiens_hsa047100.33544828
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32988765
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.31179275
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31047799
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.30619977
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.30576033
121Hematopoietic cell lineage_Homo sapiens_hsa046400.30430411
122Pentose phosphate pathway_Homo sapiens_hsa000300.29972013
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29845679
124Peroxisome_Homo sapiens_hsa041460.29017716
125beta-Alanine metabolism_Homo sapiens_hsa004100.28705584
126Pyrimidine metabolism_Homo sapiens_hsa002400.28442940
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27505823
128Tight junction_Homo sapiens_hsa045300.26254144
129Fatty acid metabolism_Homo sapiens_hsa012120.24229369
130Melanoma_Homo sapiens_hsa052180.24071830
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23281323
132Fatty acid degradation_Homo sapiens_hsa000710.23055094
133Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22555178
134Herpes simplex infection_Homo sapiens_hsa051680.22167063
135Antigen processing and presentation_Homo sapiens_hsa046120.19776199
136Wnt signaling pathway_Homo sapiens_hsa043100.19519448
137Nitrogen metabolism_Homo sapiens_hsa009100.16526823

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