UBL7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)8.57612883
2daunorubicin metabolic process (GO:0044597)8.57612883
3polyketide metabolic process (GO:0030638)8.57612883
4aminoglycoside antibiotic metabolic process (GO:0030647)5.58281284
5deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.46757662
6regulation of cilium movement (GO:0003352)5.26310850
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.16851306
8regulation of nuclear cell cycle DNA replication (GO:0033262)4.83470584
9rRNA methylation (GO:0031167)4.83179502
10rRNA modification (GO:0000154)4.82484839
11maintenance of protein location in nucleus (GO:0051457)4.78982861
12pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.77003049
13protein localization to kinetochore (GO:0034501)4.74096138
14ATP synthesis coupled proton transport (GO:0015986)4.66053256
15energy coupled proton transport, down electrochemical gradient (GO:0015985)4.66053256
16chaperone-mediated protein transport (GO:0072321)4.52496804
17formation of translation preinitiation complex (GO:0001731)4.44141385
18cullin deneddylation (GO:0010388)4.36507986
19ribosome biogenesis (GO:0042254)4.35630538
20negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.34405371
21negative regulation of ligase activity (GO:0051352)4.34405371
22rRNA transcription (GO:0009303)4.33689005
23regulation of mammary gland epithelial cell proliferation (GO:0033599)4.33257259
24DNA replication checkpoint (GO:0000076)4.32016495
25proteasome assembly (GO:0043248)4.29392220
26oxidative phosphorylation (GO:0006119)4.28807273
27positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.27539976
28negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.25509269
29negative regulation of epidermis development (GO:0045683)4.24616925
30negative regulation of telomerase activity (GO:0051974)4.19196171
31regulation of mitochondrial translation (GO:0070129)4.16884422
32pyrimidine nucleotide catabolic process (GO:0006244)4.15252115
33protein complex biogenesis (GO:0070271)4.11268207
34DNA deamination (GO:0045006)4.10281063
35negative regulation of cell cycle G2/M phase transition (GO:1902750)4.07705037
36protein deneddylation (GO:0000338)4.07464469
37base-excision repair, AP site formation (GO:0006285)4.05882254
38regulation of translation in response to stress (GO:0043555)4.05541383
39protein localization to chromosome, centromeric region (GO:0071459)4.03176653
40GDP-mannose metabolic process (GO:0019673)4.02883844
41regulation of cellular amino acid metabolic process (GO:0006521)4.01048540
42respiratory electron transport chain (GO:0022904)3.97195186
43mitochondrial respiratory chain complex assembly (GO:0033108)3.93037525
44mitotic sister chromatid segregation (GO:0000070)3.91764871
45protein targeting to mitochondrion (GO:0006626)3.91537316
46regulation of telomere maintenance via telomerase (GO:0032210)3.90132344
47signal transduction involved in DNA damage checkpoint (GO:0072422)3.86717436
48electron transport chain (GO:0022900)3.84835811
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.83620121
50deoxyribonucleotide catabolic process (GO:0009264)3.82195727
51pseudouridine synthesis (GO:0001522)3.81447668
52pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.80225224
53metallo-sulfur cluster assembly (GO:0031163)3.77027553
54iron-sulfur cluster assembly (GO:0016226)3.77027553
55histone H4-K5 acetylation (GO:0043981)3.74034760
56histone H4-K8 acetylation (GO:0043982)3.74034760
57establishment of protein localization to mitochondrial membrane (GO:0090151)3.73712631
58negative regulation of telomere maintenance (GO:0032205)3.73580101
59positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.69777771
60deoxyribose phosphate catabolic process (GO:0046386)3.69503513
61telomere maintenance via semi-conservative replication (GO:0032201)3.68142268
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.68122970
63mitochondrial respiratory chain complex I assembly (GO:0032981)3.68122970
64NADH dehydrogenase complex assembly (GO:0010257)3.68122970
65regulation of response to osmotic stress (GO:0047484)3.66612381
66establishment of integrated proviral latency (GO:0075713)3.63782243
67DNA strand elongation involved in DNA replication (GO:0006271)3.63513701
68establishment of protein localization to mitochondrion (GO:0072655)3.63506130
69transcription from mitochondrial promoter (GO:0006390)3.62919773
70protein maturation by protein folding (GO:0022417)3.62595450
71peptidyl-arginine omega-N-methylation (GO:0035247)3.60129815
72histone H4-K12 acetylation (GO:0043983)3.59394370
73positive regulation of ligase activity (GO:0051351)3.58126947
74guanosine-containing compound biosynthetic process (GO:1901070)3.57167183
75cytochrome complex assembly (GO:0017004)3.56660654
76regulation of MHC class I biosynthetic process (GO:0045343)3.53614169
77DNA replication-dependent nucleosome assembly (GO:0006335)3.52602971
78DNA replication-dependent nucleosome organization (GO:0034723)3.52602971
79protein localization to mitochondrion (GO:0070585)3.52218335
80respiratory chain complex IV assembly (GO:0008535)3.50386482
81establishment of viral latency (GO:0019043)3.49175132
82interferon-gamma production (GO:0032609)3.48388057
83negative regulation of epidermal cell differentiation (GO:0045605)3.47710672
84DNA strand elongation (GO:0022616)3.47615180
85regulation of G0 to G1 transition (GO:0070316)3.46318412
86deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.46246042
87antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.45717085
88quinone metabolic process (GO:1901661)3.45234884
89positive regulation of DNA-dependent DNA replication (GO:2000105)3.44585007
90GTP biosynthetic process (GO:0006183)3.43766109
91spliceosomal snRNP assembly (GO:0000387)3.43285703
92regulation of ubiquitin-protein transferase activity (GO:0051438)3.41337786
93sequestering of actin monomers (GO:0042989)3.38535033
94transcription elongation from RNA polymerase III promoter (GO:0006385)3.38501151
95termination of RNA polymerase III transcription (GO:0006386)3.38501151
962-deoxyribonucleotide metabolic process (GO:0009394)3.36510633
97regulation of ligase activity (GO:0051340)3.32758113
98somite rostral/caudal axis specification (GO:0032525)3.32413140
99pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.31180896
100microtubule severing (GO:0051013)3.28432369
101deoxyribose phosphate metabolic process (GO:0019692)3.27562641
102cytidine metabolic process (GO:0046087)3.26047575
103cytidine catabolic process (GO:0006216)3.26047575
104cytidine deamination (GO:0009972)3.26047575
105antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.21617455
106peptidyl-histidine modification (GO:0018202)3.21298885
107positive regulation of cell cycle arrest (GO:0071158)3.21019731
108UTP biosynthetic process (GO:0006228)3.19753100
109negative regulation of protein ubiquitination (GO:0031397)3.19064463
110CTP metabolic process (GO:0046036)3.17973453
111CTP biosynthetic process (GO:0006241)3.17973453
112pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.17267589
113muscle organ morphogenesis (GO:0048644)3.15590999
114purine nucleotide salvage (GO:0032261)3.14914596
115negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.13791172
116purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.13783935
117purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.13685874
118purine nucleoside triphosphate biosynthetic process (GO:0009145)3.13476262
119purine deoxyribonucleotide catabolic process (GO:0009155)3.12100982
120purine nucleobase biosynthetic process (GO:0009113)3.10844877
121receptor recycling (GO:0001881)3.10626236
122ribonucleoprotein complex biogenesis (GO:0022613)3.09147025
123tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.06621811
124RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.06621811
125negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.05818975
126protein polyglutamylation (GO:0018095)3.04308408
127ATP biosynthetic process (GO:0006754)3.04186853
128ribonucleoside triphosphate biosynthetic process (GO:0009201)3.03504395
129deoxyribonucleotide metabolic process (GO:0009262)3.03186351
130regulation of cellular amine metabolic process (GO:0033238)3.02842226
131negative regulation of B cell apoptotic process (GO:0002903)3.02282826
132pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.02063650
133purine deoxyribonucleotide metabolic process (GO:0009151)3.00992528
134nucleobase biosynthetic process (GO:0046112)2.96849789
135mitochondrial DNA replication (GO:0006264)2.94686050
136sister chromatid segregation (GO:0000819)2.90858903
137regulation of telomerase activity (GO:0051972)2.90699576
138DNA replication initiation (GO:0006270)2.89551844
139nucleoside transmembrane transport (GO:1901642)2.82353083
140fusion of sperm to egg plasma membrane (GO:0007342)2.80436878
141heterochromatin organization (GO:0070828)2.77471688
142regulation of apoptotic process involved in morphogenesis (GO:1902337)2.75552855
143L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.74459970
144regulation of microtubule-based movement (GO:0060632)2.72880862
145negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.72262844
146cellular component biogenesis (GO:0044085)2.70649172
147ribosomal small subunit assembly (GO:0000028)2.69160885
148positive regulation of protein deacetylation (GO:0090312)2.64584964
149maintenance of protein localization in organelle (GO:0072595)2.62238619
150DNA damage response, detection of DNA damage (GO:0042769)2.61713054
151histone arginine methylation (GO:0034969)2.59438199
152positive regulation of protein import into nucleus, translocation (GO:0033160)2.58578590
153histone H4-K16 acetylation (GO:0043984)2.57441256
154intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.56733170
155DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.55528821
156negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.51997136
157seminiferous tubule development (GO:0072520)2.51750856
158pyrimidine ribonucleoside catabolic process (GO:0046133)2.50233068
159intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.49034873
160signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.49034873
161signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.47490998
162signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.47490998
163signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.47490998
164regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.47102353
165apoptotic DNA fragmentation (GO:0006309)2.46820879
166transcription from RNA polymerase I promoter (GO:0006360)2.44682049
167chromatin assembly (GO:0031497)2.43275620
168anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.42949797
169regulation of double-strand break repair via homologous recombination (GO:0010569)2.42710439
170notochord development (GO:0030903)2.42139913
171pteridine-containing compound biosynthetic process (GO:0042559)2.39480457
172regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.39177147
173regulation of double-strand break repair (GO:2000779)2.38727194
174DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.38634707
175signal transduction involved in cell cycle checkpoint (GO:0072395)2.38346723
176mitotic nuclear envelope disassembly (GO:0007077)2.38147990
177mitochondrial DNA metabolic process (GO:0032042)2.38089671
178DNA damage response, signal transduction resulting in transcription (GO:0042772)2.38016761
179signal transduction involved in DNA integrity checkpoint (GO:0072401)2.37900817

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.82269233
2E2F7_22180533_ChIP-Seq_HELA_Human3.74138838
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.62380165
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.19652881
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.99123373
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.71599940
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.70210608
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.70210608
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.70210608
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60854769
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.51300154
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.44116382
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.36041669
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.33716353
15* EST1_17652178_ChIP-ChIP_JURKAT_Human2.30788318
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.29064526
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.24713225
18* ETS1_20019798_ChIP-Seq_JURKAT_Human2.17533664
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.12953681
20YY1_21170310_ChIP-Seq_MESCs_Mouse2.11073615
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.09592006
22* GABP_17652178_ChIP-ChIP_JURKAT_Human2.09057152
23NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.07497468
24MYC_19079543_ChIP-ChIP_MESCs_Mouse1.93300708
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89265418
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.86808648
27FOXP3_21729870_ChIP-Seq_TREG_Human1.84519783
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.83988190
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83119019
30MYC_22102868_ChIP-Seq_BL_Human1.81119062
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80423192
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.80370281
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74026085
34* VDR_23849224_ChIP-Seq_CD4+_Human1.70598818
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.69783032
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68941264
37* GABP_19822575_ChIP-Seq_HepG2_Human1.68074921
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66993408
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.64625427
40SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.60806975
41* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59238012
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56390100
43XRN2_22483619_ChIP-Seq_HELA_Human1.56353593
44* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55001212
45SCL_19346495_ChIP-Seq_HPC-7_Human1.52241944
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49812089
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48774673
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.48436233
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43910478
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42706764
51CIITA_25753668_ChIP-Seq_RAJI_Human1.41939888
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41493427
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40610030
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38108805
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.36515728
56SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.35973193
57KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35640963
58NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.34223456
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32656704
60SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.31793922
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31671137
62* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31338016
63* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30788834
64* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30288299
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29757140
66* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29362692
67CTCF_18555785_ChIP-Seq_MESCs_Mouse1.28622084
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.27932809
69* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27198189
70* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.27108331
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27095568
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25901213
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24924052
74ELK1_19687146_ChIP-ChIP_HELA_Human1.23230574
75KDM5A_27292631_Chip-Seq_BREAST_Human1.19672225
76NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19253588
77SPI1_23547873_ChIP-Seq_NB4_Human1.16396883
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.14935831
79DCP1A_22483619_ChIP-Seq_HELA_Human1.13914430
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12628998
81* FOXP1_21924763_ChIP-Seq_HESCs_Human1.12077330
82ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11857197
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10639663
84E2F1_21310950_ChIP-Seq_MCF-7_Human1.10120582
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10093670
86YY1_22570637_ChIP-Seq_MALME-3M_Human1.10008509
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09802388
88VDR_21846776_ChIP-Seq_THP-1_Human1.09704582
89TTF2_22483619_ChIP-Seq_HELA_Human1.09192121
90* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08115198
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07926968
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07179204
93ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06336258
94* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05779152
95BCL6_27268052_Chip-Seq_Bcells_Human1.05038764
96* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.04994644
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03407888
98SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03331985
99* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02778948
100TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02014417
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01196180
102CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01086116
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99749550
104* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98938873
105TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98748776
106CTCF_26484167_Chip-Seq_Bcells_Mouse0.98127488
107TFEB_21752829_ChIP-Seq_HELA_Human0.98075571
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97913444
109NANOG_21062744_ChIP-ChIP_HESCs_Human0.97054086
110BCOR_27268052_Chip-Seq_Bcells_Human0.97003652
111OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96183167
112IRF1_19129219_ChIP-ChIP_H3396_Human0.96091396
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95836034
114MYC_18940864_ChIP-ChIP_HL60_Human0.93875496
115CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92485307
116TBX5_21415370_ChIP-Seq_HL-1_Mouse0.92462849
117SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91954676
118IRF8_22096565_ChIP-ChIP_GC-B_Human0.91534339
119EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.91444594
120PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90984652
121PHF8_20622854_ChIP-Seq_HELA_Human0.90858339
122TCF7_22412390_ChIP-Seq_EML_Mouse0.90535067
123P68_20966046_ChIP-Seq_HELA_Human0.89287366
124* TET1_21451524_ChIP-Seq_MESCs_Mouse0.88415746
125CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87858406
126FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87231969
127RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.86531605
128* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85513484

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.58213866
2MP0003011_delayed_dark_adaptation3.37801667
3MP0005075_abnormal_melanosome_morpholog3.33811099
4MP0004957_abnormal_blastocyst_morpholog3.18361895
5MP0004264_abnormal_extraembryonic_tissu3.12351100
6MP0002396_abnormal_hematopoietic_system2.73842613
7MP0008260_abnormal_autophagy2.72479616
8MP0003693_abnormal_embryo_hatching2.59170240
9MP0005394_taste/olfaction_phenotype2.54457894
10MP0005499_abnormal_olfactory_system2.54457894
11MP0006035_abnormal_mitochondrial_morpho2.49985296
12MP0002653_abnormal_ependyma_morphology2.46832175
13MP0003077_abnormal_cell_cycle2.45231904
14MP0008057_abnormal_DNA_replication2.33526169
15MP0002822_catalepsy2.28213991
16MP0001529_abnormal_vocalization2.20173620
17MP0003183_abnormal_peptide_metabolism2.18785492
18MP0005410_abnormal_fertilization2.12796458
19MP0003111_abnormal_nucleus_morphology2.12549420
20MP0010094_abnormal_chromosome_stability2.11066423
21MP0003123_paternal_imprinting2.06888174
22MP0005084_abnormal_gallbladder_morpholo2.06622281
23MP0003122_maternal_imprinting2.04621820
24MP0000372_irregular_coat_pigmentation2.02201183
25MP0003121_genomic_imprinting1.98266636
26MP0008058_abnormal_DNA_repair1.91144739
27MP0002254_reproductive_system_inflammat1.88986661
28MP0008007_abnormal_cellular_replicative1.86723211
29MP0002332_abnormal_exercise_endurance1.81503468
30MP0003880_abnormal_central_pattern1.80371251
31MP0005397_hematopoietic_system_phenotyp1.76554431
32MP0001545_abnormal_hematopoietic_system1.76554431
33MP0006036_abnormal_mitochondrial_physio1.75871350
34MP0002163_abnormal_gland_morphology1.74772897
35MP0002132_abnormal_respiratory_system1.74573017
36MP0008877_abnormal_DNA_methylation1.74543830
37MP0004858_abnormal_nervous_system1.73445293
38MP0001764_abnormal_homeostasis1.60762008
39MP0003718_maternal_effect1.60274801
40MP0001672_abnormal_embryogenesis/_devel1.59835096
41MP0005380_embryogenesis_phenotype1.59835096
42MP0003984_embryonic_growth_retardation1.57133247
43MP0004808_abnormal_hematopoietic_stem1.57075974
44MP0005671_abnormal_response_to1.56974316
45MP0000490_abnormal_crypts_of1.55043494
46MP0002088_abnormal_embryonic_growth/wei1.54821533
47MP0005451_abnormal_body_composition1.53450106
48MP0000350_abnormal_cell_proliferation1.52268459
49MP0003890_abnormal_embryonic-extraembry1.50177291
50MP0000313_abnormal_cell_death1.49202701
51MP0000678_abnormal_parathyroid_gland1.47052115
52MP0001905_abnormal_dopamine_level1.46666443
53MP0001835_abnormal_antigen_presentation1.43415116
54MP0006082_CNS_inflammation1.38700134
55MP0005257_abnormal_intraocular_pressure1.38044263
56MP0003786_premature_aging1.37150696
57MP0000749_muscle_degeneration1.36226556
58MP0001293_anophthalmia1.33588608
59MP0002398_abnormal_bone_marrow1.33326523
60MP0000689_abnormal_spleen_morphology1.32241259
61MP0003787_abnormal_imprinting1.30722263
62MP0009785_altered_susceptibility_to1.29113540
63MP0002722_abnormal_immune_system1.28578254
64MP0008789_abnormal_olfactory_epithelium1.28323174
65MP0002234_abnormal_pharynx_morphology1.27156166
66MP0003186_abnormal_redox_activity1.24052272
67MP0005645_abnormal_hypothalamus_physiol1.24027070
68MP0005266_abnormal_metabolism1.23674808
69MP0002148_abnormal_hypersensitivity_rea1.19854909
70MP0002127_abnormal_cardiovascular_syste1.19255039
71MP0000358_abnormal_cell_content/1.18919608
72MP0005464_abnormal_platelet_physiology1.17441155
73MP0003646_muscle_fatigue1.16406856
74MP0001929_abnormal_gametogenesis1.16230042
75MP0003656_abnormal_erythrocyte_physiolo1.15736162
76MP0010352_gastrointestinal_tract_polyps1.15508405
77MP0002429_abnormal_blood_cell1.14188676
78MP0001730_embryonic_growth_arrest1.13894616
79MP0002019_abnormal_tumor_incidence1.10499644
80MP0009697_abnormal_copulation1.10115032
81MP0001849_ear_inflammation1.09574102
82MP0005330_cardiomyopathy1.09101017
83MP0005423_abnormal_somatic_nervous1.09099126
84MP0009333_abnormal_splenocyte_physiolog1.09096568
85MP0002736_abnormal_nociception_after1.05273180
86MP0008932_abnormal_embryonic_tissue1.04541902
87MP0000685_abnormal_immune_system1.03460534
88MP0000716_abnormal_immune_system1.02109171
89MP0002080_prenatal_lethality1.01298209
90MP0002269_muscular_atrophy1.01189578
91MP0002086_abnormal_extraembryonic_tissu0.99318245
92MP0003698_abnormal_male_reproductive0.98657835
93MP0001346_abnormal_lacrimal_gland0.98361444
94MP0000343_altered_response_to0.97814025
95MP0003315_abnormal_perineum_morphology0.96035279
96MP0001145_abnormal_male_reproductive0.95685469
97MP0003763_abnormal_thymus_physiology0.95509359
98MP0000750_abnormal_muscle_regeneration0.95292003
99MP0003806_abnormal_nucleotide_metabolis0.94450930
100MP0001800_abnormal_humoral_immune0.94213494
101MP0001697_abnormal_embryo_size0.93188444
102MP0005319_abnormal_enzyme/_coenzyme0.93165139
103MP0002210_abnormal_sex_determination0.93117978
104MP0004084_abnormal_cardiac_muscle0.93090194
105MP0009278_abnormal_bone_marrow0.90135002
106MP0008873_increased_physiological_sensi0.90027350
107MP0004147_increased_porphyrin_level0.90023217
108MP0002970_abnormal_white_adipose0.89897755
109MP0005025_abnormal_response_to0.89648031
110MP0003436_decreased_susceptibility_to0.87816186
111MP0000015_abnormal_ear_pigmentation0.87636137
112MP0000703_abnormal_thymus_morphology0.87623004
113MP0002405_respiratory_system_inflammati0.87240112
114MP0001853_heart_inflammation0.85514881
115MP0002420_abnormal_adaptive_immunity0.85439685
116MP0001819_abnormal_immune_cell0.84083282
117MP0002160_abnormal_reproductive_system0.81323688
118MP0005000_abnormal_immune_tolerance0.81150981
119MP0010030_abnormal_orbit_morphology0.81110478
120MP0002277_abnormal_respiratory_mucosa0.81094096
121MP0005367_renal/urinary_system_phenotyp0.80369440
122MP0000516_abnormal_urinary_system0.80369440
123MP0002085_abnormal_embryonic_tissue0.79899369
124MP0005058_abnormal_lysosome_morphology0.77516789
125MP0002723_abnormal_immune_serum0.76861036
126MP0001968_abnormal_touch/_nociception0.76518645
127MP0000681_abnormal_thyroid_gland0.76198352
128MP0002735_abnormal_chemical_nociception0.75687128
129MP0003191_abnormal_cellular_cholesterol0.73434659
130MP0006276_abnormal_autonomic_nervous0.73075191
131MP0000049_abnormal_middle_ear0.73052223
132MP0001188_hyperpigmentation0.73051633
133MP0009672_abnormal_birth_weight0.73032663
134MP0003221_abnormal_cardiomyocyte_apopto0.72830746
135MP0000858_altered_metastatic_potential0.72825688
136MP0002452_abnormal_antigen_presenting0.71472374
137MP0003172_abnormal_lysosome_physiology0.69190821
138MP0005379_endocrine/exocrine_gland_phen0.68414640
139MP0004859_abnormal_synaptic_plasticity0.66549295
140MP0002102_abnormal_ear_morphology0.65440460
141MP0003567_abnormal_fetal_cardiomyocyte0.65121906

Predicted human phenotypes

RankGene SetZ-score
1Multiple enchondromatosis (HP:0005701)5.30213866
2Bilateral microphthalmos (HP:0007633)5.28485860
3Abnormal mitochondria in muscle tissue (HP:0008316)5.27130594
4Hepatocellular necrosis (HP:0001404)5.12467327
5Acute necrotizing encephalopathy (HP:0006965)5.11945407
6Mitochondrial inheritance (HP:0001427)5.02553984
7Hepatic necrosis (HP:0002605)4.63638414
8Acute encephalopathy (HP:0006846)4.54183074
9Increased CSF lactate (HP:0002490)4.49961820
10Decreased activity of mitochondrial respiratory chain (HP:0008972)4.49738413
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.49738413
12Abnormality of the lower motor neuron (HP:0002366)4.40578200
13Increased intramyocellular lipid droplets (HP:0012240)4.33737215
14Progressive macrocephaly (HP:0004481)4.08227414
15Hypochromic microcytic anemia (HP:0004840)3.98759537
16Reduced antithrombin III activity (HP:0001976)3.83664662
17Increased muscle lipid content (HP:0009058)3.82815720
18Ragged-red muscle fibers (HP:0003200)3.78006341
19Increased hepatocellular lipid droplets (HP:0006565)3.71532536
20Hepatoblastoma (HP:0002884)3.55968803
21Lactic acidosis (HP:0003128)3.55745509
22Renal Fanconi syndrome (HP:0001994)3.55304181
23Nasal polyposis (HP:0100582)3.51269134
24Aplastic anemia (HP:0001915)3.49456119
25Impulsivity (HP:0100710)3.48525197
26Exercise intolerance (HP:0003546)3.47456629
27Cerebral edema (HP:0002181)3.40247082
28Increased serum lactate (HP:0002151)3.36836353
29Lipid accumulation in hepatocytes (HP:0006561)3.36631681
30Type I transferrin isoform profile (HP:0003642)3.25374547
31Abnormality of the nasal mucosa (HP:0000433)3.24805633
32Amyotrophic lateral sclerosis (HP:0007354)3.20934058
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.19956056
34Respiratory failure (HP:0002878)3.15285500
35Progressive muscle weakness (HP:0003323)3.13577164
36Chromosomal breakage induced by crosslinking agents (HP:0003221)3.12605177
37Ependymoma (HP:0002888)3.09360619
383-Methylglutaconic aciduria (HP:0003535)3.05987782
39Microretrognathia (HP:0000308)3.04525789
40Atrophy/Degeneration involving motor neurons (HP:0007373)3.01952141
41Tongue fasciculations (HP:0001308)2.85611159
42Nephroblastoma (Wilms tumor) (HP:0002667)2.85376226
43Respiratory difficulties (HP:0002880)2.82017616
44Microvesicular hepatic steatosis (HP:0001414)2.81382379
45Trismus (HP:0000211)2.80827721
46Rib fusion (HP:0000902)2.79896552
47Abnormal gallbladder physiology (HP:0012438)2.78368268
48Cholecystitis (HP:0001082)2.78368268
49Exertional dyspnea (HP:0002875)2.77239535
50Aplasia/Hypoplasia of the fovea (HP:0008060)2.75651013
51Hypoplasia of the fovea (HP:0007750)2.75651013
52Abnormal lung lobation (HP:0002101)2.74814269
53Emotional lability (HP:0000712)2.74614642
54Rhabdomyosarcoma (HP:0002859)2.74180551
55Chromsome breakage (HP:0040012)2.73264376
56Meckel diverticulum (HP:0002245)2.71356204
57Abnormality of the anterior horn cell (HP:0006802)2.70967089
58Degeneration of anterior horn cells (HP:0002398)2.70967089
59Muscle fibrillation (HP:0010546)2.62406096
60Embryonal renal neoplasm (HP:0011794)2.61728521
61Neoplasm of striated muscle (HP:0009728)2.59300393
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.58851213
63Myelodysplasia (HP:0002863)2.56975078
64Leukodystrophy (HP:0002415)2.56184473
65Abnormality of the ileum (HP:0001549)2.55007718
66Abnormality of the heme biosynthetic pathway (HP:0010472)2.52974266
67Dicarboxylic aciduria (HP:0003215)2.51539344
68Abnormality of dicarboxylic acid metabolism (HP:0010995)2.51539344
69Rough bone trabeculation (HP:0100670)2.49452352
70Pancytopenia (HP:0001876)2.49064685
71Aplasia/Hypoplasia of the sacrum (HP:0008517)2.47981415
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.47686035
73Testicular atrophy (HP:0000029)2.45772754
74Supernumerary spleens (HP:0009799)2.40839960
75Tetraplegia (HP:0002445)2.35168817
76Premature ovarian failure (HP:0008209)2.35063561
77Facial cleft (HP:0002006)2.34766977
78Elevated erythrocyte sedimentation rate (HP:0003565)2.33858140
79Combined immunodeficiency (HP:0005387)2.31296938
80Gout (HP:0001997)2.30356479
81CNS demyelination (HP:0007305)2.29609992
82Petechiae (HP:0000967)2.26518693
83Agammaglobulinemia (HP:0004432)2.26496126
84Generalized aminoaciduria (HP:0002909)2.25089559
85Duodenal stenosis (HP:0100867)2.24570652
86Small intestinal stenosis (HP:0012848)2.24570652
87Opisthotonus (HP:0002179)2.22549314
88Methylmalonic aciduria (HP:0012120)2.21541724
89Abnormality of the motor neurons (HP:0002450)2.21350900
90Abnormal neuron morphology (HP:0012757)2.21350900
91Abnormality of glycolysis (HP:0004366)2.21211455
92Increased serum pyruvate (HP:0003542)2.21211455
93Colon cancer (HP:0003003)2.20295152
94Abnormality of the fovea (HP:0000493)2.18251595
95Abnormal cartilage morphology (HP:0002763)2.16448587
96Cerebral hypomyelination (HP:0006808)2.16050895
97Pendular nystagmus (HP:0012043)2.15233188
98Delusions (HP:0000746)2.14819105
99Hypochromic anemia (HP:0001931)2.14759933
100Rectovaginal fistula (HP:0000143)2.14400512
101Rectal fistula (HP:0100590)2.14400512
102Abnormality of cells of the erythroid lineage (HP:0012130)2.12920163
103Birth length less than 3rd percentile (HP:0003561)2.12635861
104Sparse eyelashes (HP:0000653)2.12464547
105Muscle fiber atrophy (HP:0100295)2.12066899
106Preauricular skin tag (HP:0000384)2.11269641
107Myositis (HP:0100614)2.10865706
108Hyperventilation (HP:0002883)2.10019815
109Congenital malformation of the right heart (HP:0011723)2.09412842
110Double outlet right ventricle (HP:0001719)2.09412842
111Abnormality of the labia minora (HP:0012880)2.09272781
112Cleft eyelid (HP:0000625)2.08668186
113Sloping forehead (HP:0000340)2.08096632
114Abnormality of the preputium (HP:0100587)2.07135374
115Lethargy (HP:0001254)2.06609461
116Generalized hypotonia (HP:0001290)2.05771162
117Bone marrow hypocellularity (HP:0005528)2.05663111
118Bifid tongue (HP:0010297)2.05530234
119Progressive microcephaly (HP:0000253)2.02854576
120Reticulocytopenia (HP:0001896)2.01938917
121Abnormal protein glycosylation (HP:0012346)2.01685683
122Abnormal glycosylation (HP:0012345)2.01685683
123Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01685683
124Abnormal protein N-linked glycosylation (HP:0012347)2.01685683
125Chronic obstructive pulmonary disease (HP:0006510)2.01352671
126Obstructive lung disease (HP:0006536)2.01352671
127Short 5th finger (HP:0009237)2.00601307
128Partial duplication of thumb phalanx (HP:0009944)1.99261663
129Optic disc pallor (HP:0000543)1.99017763
130Cerebral palsy (HP:0100021)1.98835050
131Intestinal fistula (HP:0100819)1.98478863
132CNS hypomyelination (HP:0003429)1.98412293
133Severe global developmental delay (HP:0011344)1.97866935
134Horizontal nystagmus (HP:0000666)1.97192070
135Type 2 muscle fiber atrophy (HP:0003554)1.96379222
136Thrombocytosis (HP:0001894)1.94367090
137Cholelithiasis (HP:0001081)1.94220003
138Orchitis (HP:0100796)1.93105349
139Upper motor neuron abnormality (HP:0002127)1.92707092
140Myopathic facies (HP:0002058)1.92593015
141Vaginal fistula (HP:0004320)1.92426559
142Poor head control (HP:0002421)1.91820574
143Gliosis (HP:0002171)1.90855461
144Neoplasm of the adrenal gland (HP:0100631)1.90655219
145Abnormality of the salivary glands (HP:0010286)1.89053555
146Progressive external ophthalmoplegia (HP:0000590)1.84087817
147Carpal bone hypoplasia (HP:0001498)1.83488962
148Rhabdomyolysis (HP:0003201)1.82403658
149X-linked dominant inheritance (HP:0001423)1.82211943
150Skin tags (HP:0010609)1.81181302
151Macrocytic anemia (HP:0001972)1.81022319
152IgM deficiency (HP:0002850)1.79606235
153Broad foot (HP:0001769)1.78846433
154Spastic paraparesis (HP:0002313)1.78636951
155Abnormal pupillary function (HP:0007686)1.78063394
156Hyperinsulinemic hypoglycemia (HP:0000825)1.77399854
157Abnormal number of erythroid precursors (HP:0012131)1.76664829
158Abnormal gallbladder morphology (HP:0012437)1.76565284
159Exercise-induced muscle cramps (HP:0003710)1.75706566
160Abnormal umbilical cord blood vessels (HP:0011403)1.74901626
161Single umbilical artery (HP:0001195)1.74901626
162Abnormality of the fetal cardiovascular system (HP:0010948)1.74901626
163Abnormality of renal resorption (HP:0011038)1.72598621
164Broad distal phalanx of finger (HP:0009836)1.72449870
165Secondary amenorrhea (HP:0000869)1.71841799
166Abnormality of liposaccharide metabolism (HP:0010968)1.71839371
167Abnormality of glycosphingolipid metabolism (HP:0004343)1.71839371
168Abnormality of glycolipid metabolism (HP:0010969)1.71839371
169Hypertensive crisis (HP:0100735)1.71228353
170Hypoplastic left heart (HP:0004383)1.70789459
171Nausea (HP:0002018)1.70131933
172Methylmalonic acidemia (HP:0002912)1.68263303
173Abnormality of lateral ventricle (HP:0030047)1.67721028
174Hepatosplenomegaly (HP:0001433)1.66919479

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.95342576
2CDK125.45747042
3ERN13.97383955
4GRK53.85446335
5BUB13.25492640
6GRK63.13967379
7ADRBK22.72669366
8CSF1R2.65558731
9SMG12.29412643
10TGFBR22.26772074
11PDK42.25921874
12PDK32.25921874
13PBK2.18774323
14TAF12.15432024
15GRK12.03077497
16MATK2.02707178
17WEE11.89667282
18TTK1.80911866
19CSNK1G31.75628595
20MAPK71.72057549
21NUAK11.67398240
22NME11.63053488
23CCNB11.62499885
24NEK11.61685489
25MAP3K111.61212631
26ZAK1.55856275
27NEK21.52820755
28CDK71.48636222
29CDK191.45330010
30STK101.44475021
31TESK11.42726810
32EIF2AK11.42232085
33PLK41.42106559
34MOS1.41256397
35PAK41.39603030
36DYRK21.37980848
37LIMK11.37921190
38PLK11.35140672
39AKT31.34056609
40GRK71.32373384
41MAP2K61.31841063
42CSNK1A1L1.31742400
43TRIM281.31326981
44CSNK1G21.31095869
45STK161.29061631
46SIK31.27801818
47PRKG21.23679576
48NME21.23352280
49TESK21.22546595
50MST41.21629842
51CSNK1G11.19295651
52PLK31.16751454
53MAP4K21.14664926
54PIM21.12158381
55CAMK41.10632422
56PDK21.09390121
57CHEK21.09349666
58KIT1.03767337
59ABL21.02869172
60BCKDK1.01474161
61BRSK20.98749803
62ZAP700.95779233
63DYRK30.95290366
64CDK80.95237354
65PRKD30.95197315
66TSSK60.94078011
67MAP4K10.93041130
68MAPKAPK30.92984688
69TAOK20.90465897
70TYRO30.89750730
71DAPK30.85805225
72BRSK10.85481483
73ARAF0.85402207
74TNK20.83557382
75DAPK10.82980815
76MAP2K30.82563111
77MUSK0.79932273
78MAP2K70.78898315
79MAP2K40.75074972
80TAOK10.74016852
81STK40.70748057
82IKBKB0.68732151
83LRRK20.67623481
84MAP3K120.66914760
85FGFR30.66667718
86ACVR1B0.66550610
87MARK20.63996739
88CDK140.62997050
89RPS6KA50.62369178
90CDK11A0.62285254
91TLK10.62099754
92CHEK10.61143948
93SRPK10.59261859
94IRAK30.59197979
95ADRBK10.58857940
96MAP3K80.58281266
97CDK180.57602560
98CDK150.57214857
99CSNK2A10.56907939
100TXK0.56537468
101KDR0.56379438
102AKT20.55769066
103HIPK20.54525703
104CSNK2A20.54368466
105CDC70.52892731
106CDK40.52685904
107IRAK40.52290344
108PINK10.51769897
109EIF2AK30.51567666
110AURKA0.51281980
111ALK0.51232644
112SCYL20.51066552
113MAP3K100.50170072
114RPS6KB20.48299856
115WNK10.48040631
116EIF2AK20.47397044
117AURKB0.47337008
118FES0.46378632
119IRAK20.46292506
120TIE10.46166271
121MYLK0.45969364
122ILK0.45196309
123PRKCI0.44350998
124PIM10.44282396
125MINK10.43799357
126ATR0.43573030
127MAP3K70.42742039
128VRK10.42353718
129BLK0.41791325
130ERBB30.41549263
131SYK0.41030668
132MAPK120.40657711
133BRAF0.39615589
134CAMKK20.39286419
135MAPKAPK50.37858457
136FLT30.36802997
137MAPK40.36533080
138PAK10.36142494
139BTK0.35153364
140RPS6KA40.34843506
141TBK10.33144407
142EPHA40.33143708
143CDK20.31757732
144CHUK0.31341998
145BMPR20.30981591
146PAK60.28415486
147TYK20.26217883
148MAPK110.26095517
149LYN0.25496675

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.50220629
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.06824511
3Oxidative phosphorylation_Homo sapiens_hsa001903.58369412
4DNA replication_Homo sapiens_hsa030303.22974817
5Fructose and mannose metabolism_Homo sapiens_hsa000513.13681066
6Proteasome_Homo sapiens_hsa030502.78165865
7RNA polymerase_Homo sapiens_hsa030202.68513841
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.53006797
9RNA transport_Homo sapiens_hsa030132.45267223
10Ribosome_Homo sapiens_hsa030102.28065484
11Galactose metabolism_Homo sapiens_hsa000522.25509372
12Mismatch repair_Homo sapiens_hsa034302.22992313
13Base excision repair_Homo sapiens_hsa034102.21361826
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.08775268
15Alzheimers disease_Homo sapiens_hsa050102.06225635
16Fatty acid elongation_Homo sapiens_hsa000622.02891933
17Pentose phosphate pathway_Homo sapiens_hsa000301.96048897
18Pyrimidine metabolism_Homo sapiens_hsa002401.94401151
19Spliceosome_Homo sapiens_hsa030401.85337962
20Cell cycle_Homo sapiens_hsa041101.76967564
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.73376164
22Fanconi anemia pathway_Homo sapiens_hsa034601.68703213
23Homologous recombination_Homo sapiens_hsa034401.66738310
24RNA degradation_Homo sapiens_hsa030181.65604405
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.63600863
26Basal transcription factors_Homo sapiens_hsa030221.63403846
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50648094
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.50218955
29Nucleotide excision repair_Homo sapiens_hsa034201.46097760
30Regulation of autophagy_Homo sapiens_hsa041401.45548210
31Arachidonic acid metabolism_Homo sapiens_hsa005901.45355315
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44768860
33Protein export_Homo sapiens_hsa030601.40404377
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39096340
35Folate biosynthesis_Homo sapiens_hsa007901.37534014
36Carbon metabolism_Homo sapiens_hsa012001.33258797
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32337284
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.30612570
39Biosynthesis of amino acids_Homo sapiens_hsa012301.29575260
40Purine metabolism_Homo sapiens_hsa002301.28281483
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26462425
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20441259
43mRNA surveillance pathway_Homo sapiens_hsa030151.20398370
44Thyroid cancer_Homo sapiens_hsa052161.20155149
45Primary immunodeficiency_Homo sapiens_hsa053401.19106625
46Glutathione metabolism_Homo sapiens_hsa004801.18668619
47Cardiac muscle contraction_Homo sapiens_hsa042601.11633516
48p53 signaling pathway_Homo sapiens_hsa041151.09155041
49Herpes simplex infection_Homo sapiens_hsa051681.07620530
50Sulfur relay system_Homo sapiens_hsa041221.02246699
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.01340029
52Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01032841
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99035114
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93925028
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91886445
56Other glycan degradation_Homo sapiens_hsa005110.90958029
57Sulfur metabolism_Homo sapiens_hsa009200.90851194
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89892503
59Collecting duct acid secretion_Homo sapiens_hsa049660.89543111
60Acute myeloid leukemia_Homo sapiens_hsa052210.84227425
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.83842351
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83566164
63Linoleic acid metabolism_Homo sapiens_hsa005910.80999871
64Legionellosis_Homo sapiens_hsa051340.79655857
65Propanoate metabolism_Homo sapiens_hsa006400.77357082
66Antigen processing and presentation_Homo sapiens_hsa046120.75799977
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74669198
68Vibrio cholerae infection_Homo sapiens_hsa051100.73982007
69Epstein-Barr virus infection_Homo sapiens_hsa051690.71989490
70Systemic lupus erythematosus_Homo sapiens_hsa053220.71965093
71Peroxisome_Homo sapiens_hsa041460.70322344
72Asthma_Homo sapiens_hsa053100.67549958
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64585996
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.63819270
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61956467
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61497311
77mTOR signaling pathway_Homo sapiens_hsa041500.61200163
78Influenza A_Homo sapiens_hsa051640.59185481
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57689379
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57066634
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.57029743
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56433123
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56311459
84Measles_Homo sapiens_hsa051620.55331810
85N-Glycan biosynthesis_Homo sapiens_hsa005100.54774772
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54733597
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54349677
88Pyruvate metabolism_Homo sapiens_hsa006200.54131360
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.53848800
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52960128
91Apoptosis_Homo sapiens_hsa042100.52200121
92One carbon pool by folate_Homo sapiens_hsa006700.51775878
93Arginine and proline metabolism_Homo sapiens_hsa003300.49206137
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49154559
95Autoimmune thyroid disease_Homo sapiens_hsa053200.48475528
96Oocyte meiosis_Homo sapiens_hsa041140.47246119
97Viral myocarditis_Homo sapiens_hsa054160.44764984
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.43410782
99Graft-versus-host disease_Homo sapiens_hsa053320.42422756
100Leishmaniasis_Homo sapiens_hsa051400.40388592
101Metabolic pathways_Homo sapiens_hsa011000.37556649
102Type I diabetes mellitus_Homo sapiens_hsa049400.36897116
103Allograft rejection_Homo sapiens_hsa053300.36840399
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.36800949
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.35247078
106Non-homologous end-joining_Homo sapiens_hsa034500.35068211
107Steroid biosynthesis_Homo sapiens_hsa001000.34149777
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33723129
109B cell receptor signaling pathway_Homo sapiens_hsa046620.33134723
110Notch signaling pathway_Homo sapiens_hsa043300.31157934
111Fatty acid metabolism_Homo sapiens_hsa012120.30529592
112Alcoholism_Homo sapiens_hsa050340.30474240
113Rheumatoid arthritis_Homo sapiens_hsa053230.29913478
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.28996508
115Hematopoietic cell lineage_Homo sapiens_hsa046400.27682293
116Huntingtons disease_Homo sapiens_hsa050160.27167040
117HTLV-I infection_Homo sapiens_hsa051660.26529234
118Shigellosis_Homo sapiens_hsa051310.24575050
119HIF-1 signaling pathway_Homo sapiens_hsa040660.23897421
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23886454
121Viral carcinogenesis_Homo sapiens_hsa052030.22025707
122Selenocompound metabolism_Homo sapiens_hsa004500.21948815
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.17090009
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.15674647
125Inositol phosphate metabolism_Homo sapiens_hsa005620.15196002
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14414402
127Tyrosine metabolism_Homo sapiens_hsa003500.14272091
128Phenylalanine metabolism_Homo sapiens_hsa003600.14211240
129Non-small cell lung cancer_Homo sapiens_hsa052230.14130820
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.13805044
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.13377245
132Caffeine metabolism_Homo sapiens_hsa002320.12677933
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12631654
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.12364211
135Salmonella infection_Homo sapiens_hsa051320.11512573
136Synaptic vesicle cycle_Homo sapiens_hsa047210.10985073
137Phagosome_Homo sapiens_hsa041450.10452551
138Parkinsons disease_Homo sapiens_hsa050120.09326530

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