UBL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.67762527
2central nervous system myelination (GO:0022010)5.67762527
3negative regulation of neurotransmitter secretion (GO:0046929)5.22072585
4fatty acid elongation (GO:0030497)4.58804642
5myelination (GO:0042552)4.20460712
6ensheathment of neurons (GO:0007272)4.19800280
7axon ensheathment (GO:0008366)4.19800280
8negative regulation of neurotransmitter transport (GO:0051589)4.14679718
9presynaptic membrane assembly (GO:0097105)3.95507587
10long-chain fatty acid biosynthetic process (GO:0042759)3.92321924
11cellular potassium ion homeostasis (GO:0030007)3.88347657
12sodium ion export (GO:0071436)3.85959702
13presynaptic membrane organization (GO:0097090)3.62924047
14ER overload response (GO:0006983)3.40514812
15response to redox state (GO:0051775)3.35399645
16response to hepatocyte growth factor (GO:0035728)3.26030502
17cellular response to hepatocyte growth factor stimulus (GO:0035729)3.26030502
18glutamate secretion (GO:0014047)3.22055639
19synaptic vesicle docking involved in exocytosis (GO:0016081)3.21473308
20Rap protein signal transduction (GO:0032486)3.15588506
21neuronal action potential propagation (GO:0019227)3.12995592
22oligodendrocyte differentiation (GO:0048709)3.09523811
23substantia nigra development (GO:0021762)3.09507584
24regulation of collateral sprouting (GO:0048670)3.08858319
25negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.08432798
26L-amino acid import (GO:0043092)3.07867276
27glycerophospholipid catabolic process (GO:0046475)3.05540316
28cholesterol biosynthetic process (GO:0006695)3.03724910
29photoreceptor cell differentiation (GO:0046530)3.01578367
30eye photoreceptor cell differentiation (GO:0001754)3.01578367
31transmission of nerve impulse (GO:0019226)3.01262209
32positive regulation of action potential (GO:0045760)3.00958292
33adhesion of symbiont to host cell (GO:0044650)2.96752061
34virion attachment to host cell (GO:0019062)2.96752061
35phagosome maturation (GO:0090382)2.92385473
36synaptic vesicle maturation (GO:0016188)2.91667877
37neutrophil activation involved in immune response (GO:0002283)2.90124052
38regulation of ARF protein signal transduction (GO:0032012)2.89647982
39response to lipoprotein particle (GO:0055094)2.88605447
40cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.86984998
41neuron cell-cell adhesion (GO:0007158)2.86299849
42cytoskeletal anchoring at plasma membrane (GO:0007016)2.78933316
43regulation of synaptic vesicle exocytosis (GO:2000300)2.77578604
44nucleotide transmembrane transport (GO:1901679)2.75174958
45magnesium ion transport (GO:0015693)2.74019026
46potassium ion import (GO:0010107)2.72789506
47macroautophagy (GO:0016236)2.72495084
48transferrin transport (GO:0033572)2.72338023
49sterol biosynthetic process (GO:0016126)2.67490389
50peptidyl-tyrosine autophosphorylation (GO:0038083)2.67209548
51negative regulation of exocytosis (GO:0045920)2.66845536
52myelination in peripheral nervous system (GO:0022011)2.66416022
53peripheral nervous system axon ensheathment (GO:0032292)2.66416022
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.65745506
55positive regulation of nitric-oxide synthase activity (GO:0051000)2.65133118
56cellular sodium ion homeostasis (GO:0006883)2.65097724
57regulation of short-term neuronal synaptic plasticity (GO:0048172)2.64990313
58glycosylceramide metabolic process (GO:0006677)2.64628617
59myelin maintenance (GO:0043217)2.62727132
60nerve growth factor signaling pathway (GO:0038180)2.62582168
61ionotropic glutamate receptor signaling pathway (GO:0035235)2.60648909
62asymmetric protein localization (GO:0008105)2.60151882
63ferric iron transport (GO:0015682)2.59701515
64trivalent inorganic cation transport (GO:0072512)2.59701515
65amino acid import (GO:0043090)2.59161432
66cellular response to epinephrine stimulus (GO:0071872)2.57048637
67apical protein localization (GO:0045176)2.56397156
68potassium ion homeostasis (GO:0055075)2.55592393
69positive regulation of cellular amide metabolic process (GO:0034250)2.54525624
70negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.52385743
71regulation of neuronal synaptic plasticity (GO:0048168)2.52304393
72peripheral nervous system development (GO:0007422)2.51894407
73negative regulation of protein localization to cell surface (GO:2000009)2.50820507
74ATP hydrolysis coupled proton transport (GO:0015991)2.50379787
75energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.50379787
76long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.47866703
77amyloid precursor protein metabolic process (GO:0042982)2.47286204
78Golgi to plasma membrane protein transport (GO:0043001)2.46859575
79signal peptide processing (GO:0006465)2.46183852
80detection of calcium ion (GO:0005513)2.44303681
81isoprenoid biosynthetic process (GO:0008299)2.43858190
82cell communication by electrical coupling (GO:0010644)2.43517877
83pH reduction (GO:0045851)2.43090500
84response to epinephrine (GO:0071871)2.43013553
85cyclic nucleotide catabolic process (GO:0009214)2.41869802
86long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.41016271
87cerebellar granule cell differentiation (GO:0021707)2.40610495
88amyloid precursor protein catabolic process (GO:0042987)2.40084334
89adult walking behavior (GO:0007628)2.40043473
90negative regulation of inclusion body assembly (GO:0090084)2.38860964
91intracellular pH reduction (GO:0051452)2.38325763
92creatine metabolic process (GO:0006600)2.38324420
93neuron remodeling (GO:0016322)2.37948575
94import into cell (GO:0098657)2.36705478
95membrane assembly (GO:0071709)2.35845308
96negative regulation of dendrite morphogenesis (GO:0050774)2.35683845
97leukocyte migration involved in inflammatory response (GO:0002523)2.35000006
98mating behavior (GO:0007617)2.34452015
99neuronal ion channel clustering (GO:0045161)2.33438772
100negative regulation of JUN kinase activity (GO:0043508)2.33151341
101neurotransmitter secretion (GO:0007269)2.32890439
102protein localization to endosome (GO:0036010)2.30917860
103regulation of beta-amyloid formation (GO:1902003)2.30565907
104regulation of clathrin-mediated endocytosis (GO:2000369)2.29841852
105response to monoamine (GO:0071867)2.28790052
106response to catecholamine (GO:0071869)2.28790052
107cellular response to catecholamine stimulus (GO:0071870)2.28019665
108cellular response to monoamine stimulus (GO:0071868)2.28019665
109locomotory exploration behavior (GO:0035641)2.27771358
110negative regulation of synaptic transmission (GO:0050805)2.27633179
111regulation of amyloid precursor protein catabolic process (GO:1902991)2.27583064
112regulation of long-term neuronal synaptic plasticity (GO:0048169)2.27511413
113negative regulation of axonogenesis (GO:0050771)2.26299629
114long-term synaptic potentiation (GO:0060291)2.25094262
115regulation of synaptic vesicle transport (GO:1902803)2.24166431
116astrocyte development (GO:0014002)2.23866489
117regulation of voltage-gated calcium channel activity (GO:1901385)2.23406958
118gamma-aminobutyric acid signaling pathway (GO:0007214)2.21629250
119synaptic vesicle exocytosis (GO:0016079)2.21595796
120negative regulation of synaptic transmission, GABAergic (GO:0032229)2.20387653
121cerebral cortex radially oriented cell migration (GO:0021799)2.16069133
122adhesion of symbiont to host (GO:0044406)2.15297027
123regulation of synaptic plasticity (GO:0048167)2.15109472
124activated T cell proliferation (GO:0050798)2.15034335
125eosinophil chemotaxis (GO:0048245)2.14993552
126regulation of cell communication by electrical coupling (GO:0010649)2.13709925
127glutamate receptor signaling pathway (GO:0007215)2.12613560
128positive regulation of amino acid transport (GO:0051957)2.08491978
129positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.08342269
130long-term memory (GO:0007616)2.06501382
131neural nucleus development (GO:0048857)2.06172950
132positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.05795083
133vocalization behavior (GO:0071625)2.05741739
134astrocyte differentiation (GO:0048708)2.05236705
135fatty-acyl-CoA biosynthetic process (GO:0046949)2.02999596
136response to methylmercury (GO:0051597)2.02978559
137neuron projection regeneration (GO:0031102)2.02145620
138intestinal epithelial cell development (GO:0060576)2.01110327
139adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)1.98483431
140exploration behavior (GO:0035640)1.96861948
141regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)1.96835083
142phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)1.96817422
143regulation of T-helper 2 cell differentiation (GO:0045628)1.96420335
144regulation of neurotransmitter secretion (GO:0046928)1.96249973
145positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003601.95865143
146regulation of early endosome to late endosome transport (GO:2000641)1.95606095
147regulation of Rac protein signal transduction (GO:0035020)1.94835053
148neuromuscular process controlling balance (GO:0050885)1.94773475
149clathrin coat assembly (GO:0048268)1.93609614
150positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)1.92590498
151positive regulation of glucose import (GO:0046326)1.91646852
152positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr1.90658418
153response to parathyroid hormone (GO:0071107)1.90558437
154regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 1.90552066
155cell communication involved in cardiac conduction (GO:0086065)1.90387553
156positive regulation of synaptic transmission, glutamatergic (GO:0051968)1.90042614
157regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act1.89585224
158epithelial cell differentiation involved in prostate gland development (GO:0060742)1.88976081
159embryonic retina morphogenesis in camera-type eye (GO:0060059)1.88337130
160dopamine receptor signaling pathway (GO:0007212)1.87816407
161suckling behavior (GO:0001967)1.87794732
162negative regulation of amyloid precursor protein catabolic process (GO:1902992)1.87427731
163relaxation of cardiac muscle (GO:0055119)1.87186121
164regulation of NFAT protein import into nucleus (GO:0051532)1.86274897
165postsynaptic membrane organization (GO:0001941)1.86121149
166activation of protein kinase A activity (GO:0034199)1.85754377
167regulation of neurotransmitter transport (GO:0051588)1.85396620
168regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00431.85182229
169multicellular organismal water homeostasis (GO:0050891)1.84274877

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.57593120
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.01836611
3ESR2_21235772_ChIP-Seq_MCF-7_Human2.47259184
4ESR1_20079471_ChIP-ChIP_T-47D_Human2.36115230
5TAF15_26573619_Chip-Seq_HEK293_Human2.32165667
6* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.17320224
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.10987457
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06198916
9POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96450667
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.95651201
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.93838204
12VDR_22108803_ChIP-Seq_LS180_Human1.81999704
13OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.81997386
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81817766
15* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.78319425
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.77915258
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74051204
18TRIM28_21343339_ChIP-Seq_HEK293_Human1.73380681
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70097104
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69510196
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65985444
22ER_23166858_ChIP-Seq_MCF-7_Human1.65877271
23MTF2_20144788_ChIP-Seq_MESCs_Mouse1.63256745
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63134075
25P300_19829295_ChIP-Seq_ESCs_Human1.63048124
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.61085263
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59787999
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.59258984
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.59015439
30SMAD4_21799915_ChIP-Seq_A2780_Human1.51793477
31DROSHA_22980978_ChIP-Seq_HELA_Human1.48685903
32EZH2_22144423_ChIP-Seq_EOC_Human1.48401048
33TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.45790105
34* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.45739602
35* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.45739602
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.45739121
37AR_21572438_ChIP-Seq_LNCaP_Human1.43855479
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.43661964
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.43013631
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40893178
41* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40861116
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.40827695
43* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40246331
44* SMAD3_21741376_ChIP-Seq_EPCs_Human1.38557626
45REST_21632747_ChIP-Seq_MESCs_Mouse1.37963965
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37343094
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.37285945
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36956993
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.36818528
50RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36385084
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36385084
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.35117566
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33981425
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.33887161
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32913373
56STAT3_23295773_ChIP-Seq_U87_Human1.32183556
57GATA1_22025678_ChIP-Seq_K562_Human1.31804519
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31506931
59* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31310587
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30332181
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30271257
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26863062
63TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26640227
64* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26496320
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26316263
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.25617714
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23572110
68* CMYC_18555785_Chip-Seq_ESCs_Mouse1.22946378
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22066142
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.21429823
71SUZ12_18555785_Chip-Seq_ESCs_Mouse1.20965608
72CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20938678
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20806393
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20070833
75P53_22387025_ChIP-Seq_ESCs_Mouse1.19945729
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18721315
77CLOCK_20551151_ChIP-Seq_293T_Human1.17476638
78KDM2B_26808549_Chip-Seq_K562_Human1.17241624
79SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17196127
80* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16912591
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15879724
82FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15546958
83TCF4_23295773_ChIP-Seq_U87_Human1.15298198
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.15285450
85* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14666600
86P300_18555785_Chip-Seq_ESCs_Mouse1.14313066
87E2F1_18555785_Chip-Seq_ESCs_Mouse1.13764726
88FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10765807
89AHR_22903824_ChIP-Seq_MCF-7_Human1.10072089
90P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09770954
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09371465
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.08753893
93* RARB_27405468_Chip-Seq_BRAIN_Mouse1.08584677
94SOX2_18555785_Chip-Seq_ESCs_Mouse1.07911838
95* TAL1_26923725_Chip-Seq_HPCs_Mouse1.07072627
96* RUNX2_22187159_ChIP-Seq_PCA_Human1.06848025
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06360312
98EP300_21415370_ChIP-Seq_HL-1_Mouse1.06358455
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06020165
100RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05549054
101EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04856799
102CBX2_27304074_Chip-Seq_ESCs_Mouse1.04716692
103* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04564262
104PRDM14_20953172_ChIP-Seq_ESCs_Human1.03434599
105REST_18959480_ChIP-ChIP_MESCs_Mouse1.03243011
106FUS_26573619_Chip-Seq_HEK293_Human1.02972172
107* RING1B_27294783_Chip-Seq_ESCs_Mouse1.02951107
108EZH2_27294783_Chip-Seq_NPCs_Mouse1.02829775
109* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02521565
110* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02111761
111* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01523267
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01105797
113SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00916345
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00833056
115EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00637171
116AR_25329375_ChIP-Seq_VCAP_Human1.00444017
117FOXO3_23340844_ChIP-Seq_DLD1_Human1.00346824
118NMYC_18555785_Chip-Seq_ESCs_Mouse1.00090459
119SOX2_21211035_ChIP-Seq_LN229_Gbm0.99828171
120NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98581422
121GATA2_21666600_ChIP-Seq_HMVEC_Human0.98447987
122RUNX1_27514584_Chip-Seq_MCF-7_Human0.97763063
123BP1_19119308_ChIP-ChIP_Hs578T_Human0.97469660
124SMAD1_18555785_Chip-Seq_ESCs_Mouse0.97266029
125* SOX2_20726797_ChIP-Seq_SW620_Human0.97126140
126TP63_17297297_ChIP-ChIP_HaCaT_Human0.95775708
127RNF2_27304074_Chip-Seq_NSC_Mouse0.95688444
128NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95684783
129DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94690658
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94477733
131TP53_16413492_ChIP-PET_HCT116_Human0.92298450
132* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92244879
133FOXA2_19822575_ChIP-Seq_HepG2_Human0.91583255
134SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91096231
135SMAD3_21741376_ChIP-Seq_HESCs_Human0.89977308
136* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88911691
137PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88714196
138BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88442625
139CJUN_26792858_Chip-Seq_BT549_Human0.87557541
140TP53_18474530_ChIP-ChIP_U2OS_Human0.86466191
141* TBX20_22080862_ChIP-Seq_HEART_Mouse0.85642751
142* TBX20_22328084_ChIP-Seq_HEART_Mouse0.85642751
143CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85442047
144STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.85183593
145KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84717027
146VDR_24787735_ChIP-Seq_THP-1_Human0.84706422
147RXR_22108803_ChIP-Seq_LS180_Human0.84650786
148EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84141458
149RING1B_27294783_Chip-Seq_NPCs_Mouse0.83953185
150NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83490471
151CDX2_20551321_ChIP-Seq_CACO-2_Human0.82367714
152SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.81788530

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination3.86717691
2MP0010234_abnormal_vibrissa_follicle3.65929820
3MP0003880_abnormal_central_pattern3.26310459
4MP0004270_analgesia3.23017228
5MP0003690_abnormal_glial_cell3.12660039
6MP0005171_absent_coat_pigmentation2.99700207
7MP0002272_abnormal_nervous_system2.42130537
8MP0000569_abnormal_digit_pigmentation2.40754590
9MP0002064_seizures2.37731002
10MP0009046_muscle_twitch2.21343735
11MP0003195_calcinosis2.18056091
12MP0009745_abnormal_behavioral_response2.12787876
13MP0001486_abnormal_startle_reflex2.09659798
14MP0004742_abnormal_vestibular_system2.09246268
15MP0003183_abnormal_peptide_metabolism2.01736165
16MP0001958_emphysema1.99962974
17MP0004043_abnormal_pH_regulation1.98457739
18MP0003634_abnormal_glial_cell1.98363089
19MP0002734_abnormal_mechanical_nocicepti1.97330756
20MP0003136_yellow_coat_color1.96792182
21MP0001905_abnormal_dopamine_level1.95209033
22MP0004859_abnormal_synaptic_plasticity1.94796469
23MP0004885_abnormal_endolymph1.92704730
24MP0003635_abnormal_synaptic_transmissio1.92530264
25MP0001529_abnormal_vocalization1.92345245
26MP0005646_abnormal_pituitary_gland1.91320857
27MP0001986_abnormal_taste_sensitivity1.89442942
28MP0002822_catalepsy1.88965601
29MP0005423_abnormal_somatic_nervous1.86647977
30MP0005310_abnormal_salivary_gland1.85433346
31MP0001984_abnormal_olfaction1.79046410
32MP0003705_abnormal_hypodermis_morpholog1.78635722
33MP0005058_abnormal_lysosome_morphology1.76705352
34MP0010678_abnormal_skin_adnexa1.70242074
35MP0003329_amyloid_beta_deposits1.69077272
36MP0005248_abnormal_Harderian_gland1.67718616
37MP0004142_abnormal_muscle_tone1.66194993
38MP0002572_abnormal_emotion/affect_behav1.66065992
39MP0002735_abnormal_chemical_nociception1.56448079
40MP0003191_abnormal_cellular_cholesterol1.55190748
41MP0005379_endocrine/exocrine_gland_phen1.54507782
42MP0002229_neurodegeneration1.53895432
43MP0002063_abnormal_learning/memory/cond1.52867095
44MP0003879_abnormal_hair_cell1.52805324
45MP0009780_abnormal_chondrocyte_physiolo1.52304034
46MP0002796_impaired_skin_barrier1.51290400
47MP0001485_abnormal_pinna_reflex1.50110862
48MP0010386_abnormal_urinary_bladder1.49874865
49MP0005645_abnormal_hypothalamus_physiol1.49407940
50MP0002896_abnormal_bone_mineralization1.42778516
51MP0002877_abnormal_melanocyte_morpholog1.41833507
52MP0000778_abnormal_nervous_system1.40584513
53MP0002067_abnormal_sensory_capabilities1.40552499
54MP0003950_abnormal_plasma_membrane1.40357653
55MP0003633_abnormal_nervous_system1.39584529
56MP0000013_abnormal_adipose_tissue1.39053002
57MP0002876_abnormal_thyroid_physiology1.37467437
58MP0001970_abnormal_pain_threshold1.37407559
59MP0003453_abnormal_keratinocyte_physiol1.35487381
60MP0003632_abnormal_nervous_system1.34372363
61MP0005174_abnormal_tail_pigmentation1.32402886
62MP0001968_abnormal_touch/_nociception1.32212526
63MP0000372_irregular_coat_pigmentation1.30738084
64MP0008569_lethality_at_weaning1.28176292
65MP0003631_nervous_system_phenotype1.28137715
66MP0002733_abnormal_thermal_nociception1.27629414
67MP0001440_abnormal_grooming_behavior1.24166590
68MP0005275_abnormal_skin_tensile1.22574793
69MP0004924_abnormal_behavior1.22152483
70MP0005386_behavior/neurological_phenoty1.22152483
71MP0005409_darkened_coat_color1.20976528
72MP0002736_abnormal_nociception_after1.19477687
73MP0003303_peritoneal_inflammation1.18153110
74MP0003091_abnormal_cell_migration1.17632206
75MP0000462_abnormal_digestive_system1.16269868
76MP0005551_abnormal_eye_electrophysiolog1.16149858
77MP0002148_abnormal_hypersensitivity_rea1.15257422
78MP0000383_abnormal_hair_follicle1.14892206
79MP0000604_amyloidosis1.14395568
80MP0001502_abnormal_circadian_rhythm1.14141274
81MP0001501_abnormal_sleep_pattern1.14024184
82MP0006082_CNS_inflammation1.14020822
83MP0008438_abnormal_cutaneous_collagen1.13338502
84MP0008260_abnormal_autophagy1.12546452
85MP0004381_abnormal_hair_follicle1.11537724
86MP0003300_gastrointestinal_ulcer1.11450155
87MP0001963_abnormal_hearing_physiology1.10604747
88MP0003787_abnormal_imprinting1.08793423
89MP0002882_abnormal_neuron_morphology1.08581514
90MP0002066_abnormal_motor_capabilities/c1.08251113
91MP0002693_abnormal_pancreas_physiology1.06546662
92MP0002837_dystrophic_cardiac_calcinosis1.05246067
93MP0005410_abnormal_fertilization1.04334136
94MP0005257_abnormal_intraocular_pressure1.03939774
95MP0003279_aneurysm1.03120790
96MP0003172_abnormal_lysosome_physiology1.02383907
97MP0000955_abnormal_spinal_cord1.02189269
98MP0005408_hypopigmentation1.00290170
99MP0001177_atelectasis0.97265478
100MP0001188_hyperpigmentation0.96970533
101MP0002090_abnormal_vision0.96852086
102MP0002998_abnormal_bone_remodeling0.95730276
103MP0002909_abnormal_adrenal_gland0.93616982
104MP0004510_myositis0.92132385
105MP0005388_respiratory_system_phenotype0.91074190
106MP0002133_abnormal_respiratory_system0.91074190
107MP0004134_abnormal_chest_morphology0.91032107
108MP0004484_altered_response_of0.90517077
109MP0010352_gastrointestinal_tract_polyps0.90508427
110MP0004147_increased_porphyrin_level0.89960216
111MP0008004_abnormal_stomach_pH0.89912990
112MP0009384_cardiac_valve_regurgitation0.88644040
113MP0003868_abnormal_feces_composition0.88141402
114MP0005253_abnormal_eye_physiology0.87441300
115MP0001299_abnormal_eye_distance/0.86685851
116MP0004264_abnormal_extraembryonic_tissu0.86216813
117MP0000371_diluted_coat_color0.85666392
118MP0000003_abnormal_adipose_tissue0.84120742
119MP0002557_abnormal_social/conspecific_i0.83901169
120MP0005535_abnormal_body_temperature0.81959747
121MP0005451_abnormal_body_composition0.79711775
122MP0004782_abnormal_surfactant_physiolog0.79671058
123MP0005387_immune_system_phenotype0.79185240
124MP0001790_abnormal_immune_system0.79185240
125MP0005000_abnormal_immune_tolerance0.78729715
126MP0004130_abnormal_muscle_cell0.77737480
127MP0002295_abnormal_pulmonary_circulatio0.76337421
128MP0009840_abnormal_foam_cell0.75434119
129MP0003045_fibrosis0.74544577
130MP0001851_eye_inflammation0.73803107
131MP0002163_abnormal_gland_morphology0.71738358
132MP0008874_decreased_physiological_sensi0.71467503
133MP0002971_abnormal_brown_adipose0.71349527
134MP0002419_abnormal_innate_immunity0.70745084
135MP0001542_abnormal_bone_strength0.69509606
136MP0000427_abnormal_hair_cycle0.68887516
137MP0001849_ear_inflammation0.67756311
138MP0000015_abnormal_ear_pigmentation0.67339449
139MP0005595_abnormal_vascular_smooth0.66970346
140MP0005166_decreased_susceptibility_to0.66398648
141MP0002752_abnormal_somatic_nervous0.66225973
142MP0006072_abnormal_retinal_apoptosis0.64848263
143MP0000681_abnormal_thyroid_gland0.64495264
144MP0000230_abnormal_systemic_arterial0.64453173
145MP0003075_altered_response_to0.64405594
146MP0005503_abnormal_tendon_morphology0.63590830

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)4.27901756
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.27901756
3Atonic seizures (HP:0010819)4.27827561
4Sensory axonal neuropathy (HP:0003390)4.26514451
5Neurofibrillary tangles (HP:0002185)3.88100691
6Focal motor seizures (HP:0011153)3.65207074
7Akinesia (HP:0002304)3.59648937
8Parakeratosis (HP:0001036)3.46662869
9Pheochromocytoma (HP:0002666)3.46174555
10Neuroendocrine neoplasm (HP:0100634)3.28722817
11Abnormality of the corticospinal tract (HP:0002492)3.01143073
12Obstructive sleep apnea (HP:0002870)2.99340841
13Absent frontal sinuses (HP:0002688)2.90852573
14Peripheral hypomyelination (HP:0007182)2.89540093
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.89535465
16Supranuclear gaze palsy (HP:0000605)2.81278451
17Epileptic encephalopathy (HP:0200134)2.73678211
18White forelock (HP:0002211)2.58861383
19Retinal dysplasia (HP:0007973)2.55820248
20Medial flaring of the eyebrow (HP:0010747)2.54143821
21Blue irides (HP:0000635)2.53835512
22Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.53801647
23Onion bulb formation (HP:0003383)2.53555118
24Abnormal hair whorl (HP:0010721)2.51949442
25Patchy hypopigmentation of hair (HP:0011365)2.51163764
26Intention tremor (HP:0002080)2.47287255
27Hypothermia (HP:0002045)2.45752955
28Hyperventilation (HP:0002883)2.44798047
29Increased circulating renin level (HP:0000848)2.44532792
30Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.42836191
31Abnormality of liposaccharide metabolism (HP:0010968)2.42564911
32Abnormality of glycosphingolipid metabolism (HP:0004343)2.42564911
33Abnormality of glycolipid metabolism (HP:0010969)2.42564911
34Papilledema (HP:0001085)2.42072954
35Hypomagnesemia (HP:0002917)2.40949605
36Heterochromia iridis (HP:0001100)2.40398266
37Papillary thyroid carcinoma (HP:0002895)2.40097795
38Vaginal atresia (HP:0000148)2.39223431
39Cerebral inclusion bodies (HP:0100314)2.39146604
40Cerebral hemorrhage (HP:0001342)2.38740839
41Thickened helices (HP:0000391)2.37305917
42Slow saccadic eye movements (HP:0000514)2.36290354
43Lower limb asymmetry (HP:0100559)2.33618546
44Gait imbalance (HP:0002141)2.32840868
45Spastic gait (HP:0002064)2.31255812
46Truncal ataxia (HP:0002078)2.31088792
47Genital tract atresia (HP:0001827)2.30561561
48J-shaped sella turcica (HP:0002680)2.30541094
49Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.28477038
50Asymmetry of the thorax (HP:0001555)2.28382869
51Congenital primary aphakia (HP:0007707)2.28122428
52Macroorchidism (HP:0000053)2.26843151
53Dysmetria (HP:0001310)2.26451563
54Vascular tortuosity (HP:0004948)2.22746541
55Mitral stenosis (HP:0001718)2.21255648
56Neuronal loss in central nervous system (HP:0002529)2.20627002
57Nephrogenic diabetes insipidus (HP:0009806)2.20573650
58Arterial tortuosity (HP:0005116)2.18592692
59Hyperparathyroidism (HP:0000843)2.17285438
60Dialeptic seizures (HP:0011146)2.17162403
61Mutism (HP:0002300)2.16204380
62Febrile seizures (HP:0002373)2.16167712
63Leukodystrophy (HP:0002415)2.16041930
64Urinary glycosaminoglycan excretion (HP:0003541)2.15097802
65Mucopolysacchariduria (HP:0008155)2.15097802
66Hypoplasia of the iris (HP:0007676)2.14545303
67Deformed sella turcica (HP:0002681)2.13365530
68Diminished movement (HP:0002374)2.12928564
69Myokymia (HP:0002411)2.12595966
70Postural tremor (HP:0002174)2.10916300
71Congenital sensorineural hearing impairment (HP:0008527)2.10533769
72Testicular neoplasm (HP:0010788)2.09157562
73Hypercortisolism (HP:0001578)2.08369440
74Symptomatic seizures (HP:0011145)2.08089722
75Buphthalmos (HP:0000557)2.05818288
76Abnormal auditory evoked potentials (HP:0006958)2.04800065
77Scanning speech (HP:0002168)2.03553271
78Autoamputation (HP:0001218)2.02626567
79Focal seizures (HP:0007359)2.00983009
80Congenital ichthyosiform erythroderma (HP:0007431)2.00947823
81Dysdiadochokinesis (HP:0002075)2.00913109
82Bundle branch block (HP:0011710)2.00794384
83Dysostosis multiplex (HP:0000943)2.00620638
84Diplopia (HP:0000651)1.98923253
85Abnormality of binocular vision (HP:0011514)1.98923253
86Ocular albinism (HP:0001107)1.98659487
87Increased neuronal autofluorescent lipopigment (HP:0002074)1.97105499
88Absence seizures (HP:0002121)1.96818598
89Hypoglycemic seizures (HP:0002173)1.95525852
90Acute necrotizing encephalopathy (HP:0006965)1.94752222
91Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93950195
92Abnormality of polysaccharide metabolism (HP:0011012)1.93950195
93Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93950195
94Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.93729242
95Cerebral hypomyelination (HP:0006808)1.93090971
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.90368635
97Clumsiness (HP:0002312)1.90099357
98Fetal akinesia sequence (HP:0001989)1.89552873
99Poor speech (HP:0002465)1.88508728
100Abnormal drinking behavior (HP:0030082)1.88433689
101Polydipsia (HP:0001959)1.88433689
102Hypokalemic alkalosis (HP:0001949)1.87893951
103Methylmalonic acidemia (HP:0002912)1.87800760
104Barrel-shaped chest (HP:0001552)1.87480770
105Thin bony cortex (HP:0002753)1.87424636
106Ventricular fibrillation (HP:0001663)1.87396360
107Nuclear cataract (HP:0100018)1.87058934
108Apathy (HP:0000741)1.86698666
109Generalized myoclonic seizures (HP:0002123)1.86495769
110Metabolic alkalosis (HP:0200114)1.86162907
111Segmental peripheral demyelination/remyelination (HP:0003481)1.85284270
112Ankle clonus (HP:0011448)1.85137808
113Stomatitis (HP:0010280)1.84964158
114Hyporeflexia of lower limbs (HP:0002600)1.84893586
115Abnormality of magnesium homeostasis (HP:0004921)1.84111556
116Depression (HP:0000716)1.83773444
117Abnormality of the frontal sinuses (HP:0002687)1.83608082
118Generalized tonic-clonic seizures (HP:0002069)1.83228335
119Diminished motivation (HP:0000745)1.83041529
120Hepatosplenomegaly (HP:0001433)1.82382361
121Torticollis (HP:0000473)1.81266664
122Vacuolated lymphocytes (HP:0001922)1.80965068
123Curly hair (HP:0002212)1.80954317
124Hemiplegia (HP:0002301)1.80896989
125Spastic paraparesis (HP:0002313)1.80872429
126Interstitial pulmonary disease (HP:0006530)1.80850059
127Germ cell neoplasia (HP:0100728)1.79424974
128Anteriorly placed anus (HP:0001545)1.79262567
129Disinhibition (HP:0000734)1.77779311
130Increased serum pyruvate (HP:0003542)1.77133961
131Abnormality of glycolysis (HP:0004366)1.77133961
132Progressive neurologic deterioration (HP:0002344)1.76262791
133Axonal loss (HP:0003447)1.75008561
134Progressive macrocephaly (HP:0004481)1.74704275
135Insidious onset (HP:0003587)1.74661269
136Termporal pattern (HP:0011008)1.74661269
137Lower limb muscle weakness (HP:0007340)1.74627119
138Muscle fiber splitting (HP:0003555)1.74543195
139Menstrual irregularities (HP:0000858)1.73824960
140Hyperinsulinemic hypoglycemia (HP:0000825)1.73397158
141Abnormality of renin-angiotensin system (HP:0000847)1.72962773
142Action tremor (HP:0002345)1.72200337
143Abnormality of calcium-phosphate metabolism (HP:0100530)1.71467954
144Distal lower limb muscle weakness (HP:0009053)1.71388927
145Stridor (HP:0010307)1.70510801
146Increased cerebral lipofuscin (HP:0011813)1.70505713
147Urinary urgency (HP:0000012)1.68544561
148Alacrima (HP:0000522)1.68111643
149Dynein arm defect of respiratory motile cilia (HP:0012255)1.67725730
150Absent/shortened dynein arms (HP:0200106)1.67725730
151Abnormality of the fovea (HP:0000493)1.66954191
152Abnormal eating behavior (HP:0100738)1.66841926
153Urinary incontinence (HP:0000020)1.66734175
154Gaze-evoked nystagmus (HP:0000640)1.65911145
155Hypoplasia of the fovea (HP:0007750)1.65903360
156Aplasia/Hypoplasia of the fovea (HP:0008060)1.65903360
157Overgrowth (HP:0001548)1.64683428
158Multiple lipomas (HP:0001012)1.64357688
159Urinary bladder sphincter dysfunction (HP:0002839)1.63665301
160Abnormal ciliary motility (HP:0012262)1.63330524
161Iris hypopigmentation (HP:0007730)1.60739330
162Loss of speech (HP:0002371)1.60656443
163Rigidity (HP:0002063)1.59980169
164Adrenal overactivity (HP:0002717)1.59912234
165Dysmetric saccades (HP:0000641)1.59702242

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.45669485
2OXSR13.62011257
3TNIK3.22563827
4PRPF4B3.08633498
5CASK2.80416202
6BCR2.77476088
7EPHB12.58395325
8RIPK12.46362994
9WNK42.27959420
10PNCK2.06609581
11TRIB32.05210587
12MST42.00440339
13INSRR1.95409228
14PKN11.94043478
15NEK61.90293652
16MAPK151.82626780
17NTRK21.77829335
18WNK11.76825091
19MARK11.75663320
20MAP3K141.74281480
21BMPR21.73992466
22MAP3K91.73526037
23LATS21.64643756
24CDK191.57763174
25SGK2231.56461277
26SGK4941.56461277
27PDGFRA1.51836838
28AKT31.49129298
29KSR21.45897958
30PBK1.43789413
31TYRO31.41538642
32IRAK41.38003150
33ARAF1.36779497
34IRAK11.33402456
35CAMKK11.31592565
36UHMK11.31138675
37FGFR31.31133847
38RET1.30395594
39BMPR1B1.24954443
40NTRK11.21200363
41PDGFRB1.20886775
42IRAK21.20645674
43SCYL21.18339548
44DDR21.17844563
45MAP3K21.16669325
46CAMKK21.14148440
47MET1.14071608
48FGFR21.10880393
49STK381.09752680
50CAMK2D1.07294819
51MAP3K121.06115174
52MAPK131.03482414
53PKN21.03151892
54DMPK1.02671858
55MAP3K61.02262221
56PRKCE1.01679428
57RIPK41.00743659
58CAMK2B0.98394652
59WNK30.96902172
60RPS6KA20.96755385
61PRKCQ0.95045279
62EPHA40.93481020
63MAP3K130.92371304
64TRPM70.90747414
65TESK10.90705187
66FGFR40.90079643
67STK240.88635278
68MAPKAPK50.88377098
69GRK70.87334519
70MOS0.86636419
71SGK20.85944080
72SIK10.85693255
73ROCK20.85205706
74PRKD30.83995660
75NTRK30.79605780
76MAP2K40.78786025
77CSNK1A1L0.78567323
78CLK10.78535847
79CSNK1G30.78489273
80MAP3K30.78203029
81ERBB40.77352131
82PRKCH0.76946609
83PLK20.75901406
84CDK50.75414513
85RPS6KB10.75036766
86IRAK30.74998581
87MARK20.74542553
88PTK60.74428070
89FGR0.74201985
90MAPK120.73023833
91CAMK2A0.71740947
92MAP2K70.71480198
93PAK60.70934524
94NEK90.69989503
95PDPK10.68022675
96CAMK2G0.67247996
97KSR10.65583278
98MAPK100.64780378
99PTK20.63904129
100FRK0.63688747
101FER0.63681280
102HIPK20.63314783
103GRK50.62792560
104PRKD20.60815850
105MAPKAPK30.60560000
106CSNK1G10.60173986
107FES0.59249485
108MAP2K10.57853268
109CSNK1G20.56697016
110PAK30.56295165
111IKBKE0.53147591
112ADRBK20.53139822
113SGK30.53070365
114LATS10.52097807
115PHKG10.52076990
116PHKG20.52076990
117TAOK10.52070228
118SIK30.51507913
119DAPK20.51399054
120MAPK70.51152520
121PRKG20.50985641
122YES10.50839341
123ITK0.50456026
124BRAF0.50055882
125PDK10.49712956
126JAK20.49676392
127MUSK0.49009795
128EEF2K0.48994577
129EPHA30.48016312
130IKBKB0.47505503
131ROCK10.47030798
132LIMK10.47016516
133CDK60.45799256
134TXK0.45757115
135ICK0.45725388
136FYN0.45584898
137PINK10.44947598
138CSNK1A10.44696309
139MAP3K10.44332619
140SGK10.43027650
141MINK10.41640099
142CSK0.41585823
143PRKG10.41059570
144TAOK30.39532578
145GSK3A0.39421136
146PRKACA0.38066280
147PIK3CA0.37621056
148PRKCG0.36656615
149JAK10.36127866
150PRKD10.35380783

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.21365579
2Steroid biosynthesis_Homo sapiens_hsa001002.98896272
3Collecting duct acid secretion_Homo sapiens_hsa049662.74754856
4Protein export_Homo sapiens_hsa030602.53797284
5Fatty acid elongation_Homo sapiens_hsa000622.39199099
6Sulfur metabolism_Homo sapiens_hsa009202.32864115
7Vibrio cholerae infection_Homo sapiens_hsa051102.28376018
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22038786
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.09486510
10Ether lipid metabolism_Homo sapiens_hsa005652.07814246
11Synaptic vesicle cycle_Homo sapiens_hsa047212.06220724
12Rheumatoid arthritis_Homo sapiens_hsa053232.02867295
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.98210718
14Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.79689060
15Oxidative phosphorylation_Homo sapiens_hsa001901.69216248
16GABAergic synapse_Homo sapiens_hsa047271.59671067
17SNARE interactions in vesicular transport_Homo sapiens_hsa041301.55109831
18Sphingolipid metabolism_Homo sapiens_hsa006001.53239531
19Serotonergic synapse_Homo sapiens_hsa047261.51908680
20Lysosome_Homo sapiens_hsa041421.51466044
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.46274699
22Morphine addiction_Homo sapiens_hsa050321.45146840
23Estrogen signaling pathway_Homo sapiens_hsa049151.43803615
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.43005320
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43001553
26Phagosome_Homo sapiens_hsa041451.40932252
27Glutamatergic synapse_Homo sapiens_hsa047241.29407554
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25716408
29Type I diabetes mellitus_Homo sapiens_hsa049401.24581447
30Insulin secretion_Homo sapiens_hsa049111.20472281
31Circadian entrainment_Homo sapiens_hsa047131.18673478
32GnRH signaling pathway_Homo sapiens_hsa049121.18350636
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18190419
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.17686882
35Olfactory transduction_Homo sapiens_hsa047401.15638425
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15333840
37Endometrial cancer_Homo sapiens_hsa052131.10602524
38Axon guidance_Homo sapiens_hsa043601.10079073
39Long-term depression_Homo sapiens_hsa047301.08070872
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08042620
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.07909429
42Nicotine addiction_Homo sapiens_hsa050331.05617011
43Cholinergic synapse_Homo sapiens_hsa047251.03231769
44Circadian rhythm_Homo sapiens_hsa047101.02796364
45Glioma_Homo sapiens_hsa052141.02774317
46Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01772822
47Gap junction_Homo sapiens_hsa045401.01682706
48Prolactin signaling pathway_Homo sapiens_hsa049171.01640553
49Dopaminergic synapse_Homo sapiens_hsa047280.99509725
50Alzheimers disease_Homo sapiens_hsa050100.99420494
51Melanogenesis_Homo sapiens_hsa049160.98110581
52VEGF signaling pathway_Homo sapiens_hsa043700.98088461
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94541687
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92638019
55Choline metabolism in cancer_Homo sapiens_hsa052310.92516982
56mTOR signaling pathway_Homo sapiens_hsa041500.90864154
57Amoebiasis_Homo sapiens_hsa051460.89873814
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88520358
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88303790
60Long-term potentiation_Homo sapiens_hsa047200.87885592
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86373150
62Taste transduction_Homo sapiens_hsa047420.86227478
63Butanoate metabolism_Homo sapiens_hsa006500.85069402
64Amphetamine addiction_Homo sapiens_hsa050310.84981523
65Cocaine addiction_Homo sapiens_hsa050300.84129925
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83626132
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83433382
68Regulation of autophagy_Homo sapiens_hsa041400.82925689
69Renin secretion_Homo sapiens_hsa049240.79909255
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.79332531
71Salivary secretion_Homo sapiens_hsa049700.79091765
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.77707405
73Osteoclast differentiation_Homo sapiens_hsa043800.76977767
74Parkinsons disease_Homo sapiens_hsa050120.75388471
75Autoimmune thyroid disease_Homo sapiens_hsa053200.74886244
76Thyroid hormone synthesis_Homo sapiens_hsa049180.74605971
77Rap1 signaling pathway_Homo sapiens_hsa040150.74589866
78Bile secretion_Homo sapiens_hsa049760.73850751
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73602212
80Chemokine signaling pathway_Homo sapiens_hsa040620.73407144
81Pancreatic secretion_Homo sapiens_hsa049720.72736955
82Insulin signaling pathway_Homo sapiens_hsa049100.72408660
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.71246367
84Type II diabetes mellitus_Homo sapiens_hsa049300.69964908
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69471561
86Endocytosis_Homo sapiens_hsa041440.68810803
87Graft-versus-host disease_Homo sapiens_hsa053320.68685978
88Hepatitis C_Homo sapiens_hsa051600.67964122
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67382993
90Renal cell carcinoma_Homo sapiens_hsa052110.67334305
91Linoleic acid metabolism_Homo sapiens_hsa005910.65918934
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65791956
93Ras signaling pathway_Homo sapiens_hsa040140.65761609
94Proteoglycans in cancer_Homo sapiens_hsa052050.65483635
95Vitamin B6 metabolism_Homo sapiens_hsa007500.64469086
96Non-small cell lung cancer_Homo sapiens_hsa052230.63280969
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62812243
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.62397446
99FoxO signaling pathway_Homo sapiens_hsa040680.62311036
100Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62309217
101Focal adhesion_Homo sapiens_hsa045100.60778193
102Phototransduction_Homo sapiens_hsa047440.60591505
103Adherens junction_Homo sapiens_hsa045200.59929781
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59904361
105ErbB signaling pathway_Homo sapiens_hsa040120.59668855
106Other glycan degradation_Homo sapiens_hsa005110.59590376
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59566782
108Gastric acid secretion_Homo sapiens_hsa049710.59482585
109Insulin resistance_Homo sapiens_hsa049310.59126108
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59101046
111Chronic myeloid leukemia_Homo sapiens_hsa052200.58880507
112AMPK signaling pathway_Homo sapiens_hsa041520.58683388
113B cell receptor signaling pathway_Homo sapiens_hsa046620.58521044
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58048411
115Platelet activation_Homo sapiens_hsa046110.56604789
116Arachidonic acid metabolism_Homo sapiens_hsa005900.56513065
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.55799799
118Glucagon signaling pathway_Homo sapiens_hsa049220.54716764
119cAMP signaling pathway_Homo sapiens_hsa040240.53949496
120Histidine metabolism_Homo sapiens_hsa003400.52932094
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52816682
122Thyroid cancer_Homo sapiens_hsa052160.52405304
123Allograft rejection_Homo sapiens_hsa053300.51858913
124Calcium signaling pathway_Homo sapiens_hsa040200.50163999
125Ovarian steroidogenesis_Homo sapiens_hsa049130.50118386
126Malaria_Homo sapiens_hsa051440.49624598
127Mineral absorption_Homo sapiens_hsa049780.49021610
128Salmonella infection_Homo sapiens_hsa051320.47890167
129Prion diseases_Homo sapiens_hsa050200.46571440
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.46278555
131Oxytocin signaling pathway_Homo sapiens_hsa049210.45328895
132Inositol phosphate metabolism_Homo sapiens_hsa005620.44320529
133MAPK signaling pathway_Homo sapiens_hsa040100.44177583
134Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43448783
135Tuberculosis_Homo sapiens_hsa051520.42480154
136Pertussis_Homo sapiens_hsa051330.41036838
137Dorso-ventral axis formation_Homo sapiens_hsa043200.40958259
138Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39792623
139Asthma_Homo sapiens_hsa053100.39003373
140NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38219757
141Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36024128
142cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35109253
143T cell receptor signaling pathway_Homo sapiens_hsa046600.31985677
144Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31255892
145Tight junction_Homo sapiens_hsa045300.31239186
146African trypanosomiasis_Homo sapiens_hsa051430.30939841
147Huntingtons disease_Homo sapiens_hsa050160.28280816

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