UBIAD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein thought to be involved in cholesterol and phospholipid metabolism. Mutations in this gene are associated with Schnyder crystalline corneal dystrophy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine metabolic process (GO:0006553)5.14085852
2lysine catabolic process (GO:0006554)5.14085852
3pseudouridine synthesis (GO:0001522)4.82007230
4serine family amino acid biosynthetic process (GO:0009070)4.56523289
5cysteine metabolic process (GO:0006534)4.53765886
6glyoxylate metabolic process (GO:0046487)4.28281371
7folic acid metabolic process (GO:0046655)4.27901228
8urate metabolic process (GO:0046415)4.26008999
9folic acid-containing compound biosynthetic process (GO:0009396)4.22787970
10glycine metabolic process (GO:0006544)4.15842600
11serine family amino acid metabolic process (GO:0009069)4.11489062
12serine family amino acid catabolic process (GO:0009071)3.85327614
13proteasome assembly (GO:0043248)3.83282264
14nucleobase biosynthetic process (GO:0046112)3.73948568
15purine nucleobase biosynthetic process (GO:0009113)3.73472925
16L-serine metabolic process (GO:0006563)3.71260208
17mitotic metaphase plate congression (GO:0007080)3.66473448
18cullin deneddylation (GO:0010388)3.66068029
19establishment of protein localization to mitochondrial membrane (GO:0090151)3.61094419
20mitochondrial RNA metabolic process (GO:0000959)3.58769826
21aspartate family amino acid catabolic process (GO:0009068)3.58179042
22one-carbon metabolic process (GO:0006730)3.52362958
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.52099151
24L-phenylalanine metabolic process (GO:0006558)3.52099151
25ribosomal large subunit biogenesis (GO:0042273)3.51676575
26peptidyl-histidine modification (GO:0018202)3.48443498
27metallo-sulfur cluster assembly (GO:0031163)3.46291159
28iron-sulfur cluster assembly (GO:0016226)3.46291159
29protein deneddylation (GO:0000338)3.45503992
30ribosome biogenesis (GO:0042254)3.44756486
31tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.44366239
32RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.44366239
33L-phenylalanine catabolic process (GO:0006559)3.43565513
34erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.43565513
35tricarboxylic acid metabolic process (GO:0072350)3.40935401
36folic acid-containing compound metabolic process (GO:0006760)3.40828390
37tetrahydrofolate metabolic process (GO:0046653)3.35135241
382-oxoglutarate metabolic process (GO:0006103)3.33844842
39tRNA processing (GO:0008033)3.31374971
40regulation of mitochondrial translation (GO:0070129)3.31338264
41spliceosomal snRNP assembly (GO:0000387)3.31144185
42somatic hypermutation of immunoglobulin genes (GO:0016446)3.31061267
43somatic diversification of immune receptors via somatic mutation (GO:0002566)3.31061267
44amino-acid betaine metabolic process (GO:0006577)3.30232339
45piRNA metabolic process (GO:0034587)3.28495358
46DNA strand elongation involved in DNA replication (GO:0006271)3.27393238
47tRNA modification (GO:0006400)3.27267221
48fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.26489434
49mitotic nuclear envelope disassembly (GO:0007077)3.24719736
50drug transmembrane transport (GO:0006855)3.23419914
51transcription from mitochondrial promoter (GO:0006390)3.22725529
52ribosomal small subunit assembly (GO:0000028)3.20920183
53drug transport (GO:0015893)3.20406184
54RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.20240184
55ribonucleoprotein complex biogenesis (GO:0022613)3.19460900
56mitotic chromosome condensation (GO:0007076)3.18255578
57rRNA modification (GO:0000154)3.17933110
58alpha-linolenic acid metabolic process (GO:0036109)3.16714020
59aromatic amino acid family catabolic process (GO:0009074)3.16643946
60tricarboxylic acid cycle (GO:0006099)3.16141180
61protein localization to kinetochore (GO:0034501)3.16032130
62nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.15023827
63mitochondrial respiratory chain complex assembly (GO:0033108)3.14949254
64termination of RNA polymerase III transcription (GO:0006386)3.14794889
65transcription elongation from RNA polymerase III promoter (GO:0006385)3.14794889
66rRNA processing (GO:0006364)3.13908914
67base-excision repair, AP site formation (GO:0006285)3.13825514
68sulfur amino acid catabolic process (GO:0000098)3.12819762
69drug catabolic process (GO:0042737)3.11433539
70ribosome assembly (GO:0042255)3.11280931
71exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10388197
72negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.09696451
73DNA strand elongation (GO:0022616)3.09338278
74cellular component biogenesis (GO:0044085)3.09221697
75tRNA methylation (GO:0030488)3.08056604
76protein complex biogenesis (GO:0070271)3.07589392
77rRNA metabolic process (GO:0016072)3.07203067
78mannosylation (GO:0097502)3.06442672
79DNA replication initiation (GO:0006270)3.05530615
80maturation of 5.8S rRNA (GO:0000460)3.05493904
81DNA unwinding involved in DNA replication (GO:0006268)3.04774108
82chaperone-mediated protein transport (GO:0072321)3.03490706
83tRNA metabolic process (GO:0006399)3.03017220
84aspartate family amino acid metabolic process (GO:0009066)3.02941509
85protein-cofactor linkage (GO:0018065)3.01562703
86sulfur amino acid biosynthetic process (GO:0000097)3.01233972
87mitochondrial respiratory chain complex I assembly (GO:0032981)2.99741530
88NADH dehydrogenase complex assembly (GO:0010257)2.99741530
89mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99741530
90protein K6-linked ubiquitination (GO:0085020)2.98152280
91positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.97284946
92water-soluble vitamin biosynthetic process (GO:0042364)2.96936552
93nuclear envelope disassembly (GO:0051081)2.96729325
94membrane disassembly (GO:0030397)2.96729325
95regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.96707950
96regulation of spindle organization (GO:0090224)2.95900213
97mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.95519155
98kynurenine metabolic process (GO:0070189)2.94789126
99pteridine-containing compound metabolic process (GO:0042558)2.94733571
100ncRNA processing (GO:0034470)2.94712188
101cellular ketone body metabolic process (GO:0046950)2.93857803
102IMP biosynthetic process (GO:0006188)2.93747538
103RNA modification (GO:0009451)2.93689087
104tryptophan catabolic process (GO:0006569)2.93554984
105indole-containing compound catabolic process (GO:0042436)2.93554984
106indolalkylamine catabolic process (GO:0046218)2.93554984
107DNA deamination (GO:0045006)2.91526602
108acetyl-CoA metabolic process (GO:0006084)2.91326657
109pteridine-containing compound biosynthetic process (GO:0042559)2.90975224
110ncRNA metabolic process (GO:0034660)2.90560920
111regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.89732418
112branched-chain amino acid metabolic process (GO:0009081)2.87544903
113intra-S DNA damage checkpoint (GO:0031573)2.85890673
114pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.85693451
115carnitine metabolic process (GO:0009437)2.85522379
116deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.85037659
117L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.84273045
118fatty acid beta-oxidation (GO:0006635)2.84086954
119IMP metabolic process (GO:0046040)2.83882834
120respiratory chain complex IV assembly (GO:0008535)2.82618823
121metaphase plate congression (GO:0051310)2.82269670
122DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.82246937
123sulfur amino acid metabolic process (GO:0000096)2.80905221
124negative regulation of ligase activity (GO:0051352)2.80068813
125negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.80068813
126signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.80024739
127signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.80024739
128signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.80024739
129protein targeting to mitochondrion (GO:0006626)2.79263450
130anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.78508685
131tryptophan metabolic process (GO:0006568)2.76302972
132biotin metabolic process (GO:0006768)2.76260641
133signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.75853233
134intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.75853233
135branched-chain amino acid catabolic process (GO:0009083)2.75767481
136alpha-amino acid catabolic process (GO:1901606)2.74636024
137homocysteine metabolic process (GO:0050667)2.74364760
138establishment of protein localization to mitochondrion (GO:0072655)2.72089776
139ATP synthesis coupled proton transport (GO:0015986)2.71852576
140energy coupled proton transport, down electrochemical gradient (GO:0015985)2.71852576
141telomere maintenance via semi-conservative replication (GO:0032201)2.71817622
142fatty acid elongation (GO:0030497)2.71660518
143regulation of mitotic spindle checkpoint (GO:1903504)2.71581227
144regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.71581227
145protein localization to chromosome, centromeric region (GO:0071459)2.71038755
146signal transduction involved in DNA damage checkpoint (GO:0072422)2.70623245
147signal transduction involved in DNA integrity checkpoint (GO:0072401)2.70623245
148proline metabolic process (GO:0006560)2.70488043
149DNA replication checkpoint (GO:0000076)2.70246702
150formation of translation preinitiation complex (GO:0001731)2.70093842
151ethanol oxidation (GO:0006069)2.70064064
152NADH metabolic process (GO:0006734)2.69997812
153GTP biosynthetic process (GO:0006183)2.69758582
154regulation of nuclear cell cycle DNA replication (GO:0033262)2.69277710
155cellular modified amino acid catabolic process (GO:0042219)2.68357166
156signal transduction involved in cell cycle checkpoint (GO:0072395)2.68302155
157DNA damage response, detection of DNA damage (GO:0042769)2.67967806
158monoubiquitinated protein deubiquitination (GO:0035520)2.65863658
159valine metabolic process (GO:0006573)2.64849184
160regulation of cellular amino acid metabolic process (GO:0006521)2.64054342
161DNA catabolic process, exonucleolytic (GO:0000738)2.63651314
162short-chain fatty acid metabolic process (GO:0046459)2.62458282
163negative regulation of telomere maintenance (GO:0032205)2.62326489
164cellular amino acid catabolic process (GO:0009063)2.61661024
165RNA methylation (GO:0001510)2.61414812
166rRNA transcription (GO:0009303)2.60656659
167response to mercury ion (GO:0046689)2.60265175
168fatty acid oxidation (GO:0019395)2.59644509
169chromatin remodeling at centromere (GO:0031055)2.57907425
170DNA replication-dependent nucleosome organization (GO:0034723)2.57666515
171DNA replication-dependent nucleosome assembly (GO:0006335)2.57666515
172positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.57113204
173phosphate ion transport (GO:0006817)2.56605816
1744-hydroxyproline metabolic process (GO:0019471)2.56283302
175UTP biosynthetic process (GO:0006228)2.55364635
176alpha-amino acid biosynthetic process (GO:1901607)2.54748107
177phosphate ion transmembrane transport (GO:0035435)2.54129433
178regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.54114681
179* ubiquinone biosynthetic process (GO:0006744)2.52580805
180lipid oxidation (GO:0034440)2.51332948
181attachment of spindle microtubules to kinetochore (GO:0008608)2.50370083
182exogenous drug catabolic process (GO:0042738)2.49352699
183nucleoside salvage (GO:0043174)2.48217962
184oxaloacetate metabolic process (GO:0006107)2.47996946
185establishment of chromosome localization (GO:0051303)2.47150286
186nuclear envelope organization (GO:0006998)2.47091212
187bile acid biosynthetic process (GO:0006699)2.46590927
188ketone body metabolic process (GO:1902224)2.46557851
189quaternary ammonium group transport (GO:0015697)2.46434344
190dicarboxylic acid metabolic process (GO:0043648)2.45733229
191regulation of cholesterol homeostasis (GO:2000188)2.45385551
192fatty acid catabolic process (GO:0009062)2.44686893

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.94975372
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.93778133
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49491639
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.43044002
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.22827848
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.96510084
7AR_21909140_ChIP-Seq_LNCAP_Human2.87064129
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.78928936
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.71824785
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.69376650
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.61746762
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.41390783
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.37143854
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.32050481
15* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.27740509
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.20782836
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17855205
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13508273
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.09336397
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.07803091
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.07712031
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.05984097
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.03555020
24ELK1_19687146_ChIP-ChIP_HELA_Human1.97406981
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.96795946
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.95559388
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95145514
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.90145638
29ZNF274_21170338_ChIP-Seq_K562_Hela1.86440068
30MYC_22102868_ChIP-Seq_BL_Human1.85712212
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85226953
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84802492
33XRN2_22483619_ChIP-Seq_HELA_Human1.82149153
34GABP_19822575_ChIP-Seq_HepG2_Human1.78612197
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.77240819
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74481447
37LXR_22158963_ChIP-Seq_LIVER_Mouse1.69410267
38DCP1A_22483619_ChIP-Seq_HELA_Human1.68482886
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.67553003
40* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67505160
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.61238606
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60615381
43MYC_18940864_ChIP-ChIP_HL60_Human1.56477087
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.51131426
45VDR_23849224_ChIP-Seq_CD4+_Human1.50077316
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46409447
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45004187
48FOXP3_21729870_ChIP-Seq_TREG_Human1.40964452
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40848665
50VDR_22108803_ChIP-Seq_LS180_Human1.40507544
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40218348
52* SRF_21415370_ChIP-Seq_HL-1_Mouse1.39963045
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.36984665
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36757283
55* KDM5A_27292631_Chip-Seq_BREAST_Human1.36535639
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35172197
57DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33412147
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32530445
59* CIITA_25753668_ChIP-Seq_RAJI_Human1.27760226
60CLOCK_20551151_ChIP-Seq_293T_Human1.27466150
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26615698
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25862313
63ZNF263_19887448_ChIP-Seq_K562_Human1.24960286
64DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24179687
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20781246
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20603804
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16007953
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15722194
69IRF1_19129219_ChIP-ChIP_H3396_Human1.12863430
70IGF1R_20145208_ChIP-Seq_DFB_Human1.12389135
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12324712
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10840661
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10039410
74TTF2_22483619_ChIP-Seq_HELA_Human1.09311195
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08968829
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08506711
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08148716
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08084193
79ATF3_27146783_Chip-Seq_COLON_Human1.07822591
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07108228
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04351476
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04079588
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03602581
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02991576
85NANOG_21062744_ChIP-ChIP_HESCs_Human1.02838911
86FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02765428
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02579236
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00362809
89SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00226522
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00004951
91TFEB_21752829_ChIP-Seq_HELA_Human0.99969615
92VDR_21846776_ChIP-Seq_THP-1_Human0.99493703
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98398091
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97922758
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96922536
96TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96215297
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94603764
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94449666
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94326910
100NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93489070
101NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92921004
102FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91845082
103FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.91445113
104CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91184903
105ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91094601
106CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90131180
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89426521
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89385864
109CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88692960
110YY1_21170310_ChIP-Seq_MESCs_Mouse0.88119747
111* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87981853
112* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84462787
113EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.82778259
114TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82267389
115SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82230579
116CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81777235
117TP53_22573176_ChIP-Seq_HFKS_Human0.81439763
118NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.80331703
119* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.80304445
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80133317
121RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.79536901
122IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.79399194
123KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.77966301
124MYB_26560356_Chip-Seq_TH2_Human0.74360635
125FOXP1_21924763_ChIP-Seq_HESCs_Human0.73848268
126YY1_22570637_ChIP-Seq_MALME-3M_Human0.73824106
127EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.71811750
128ELK1_22589737_ChIP-Seq_MCF10A_Human0.71186828
129* AR_20517297_ChIP-Seq_VCAP_Human0.70283999
130FLI1_27457419_Chip-Seq_LIVER_Mouse0.69952700
131TP63_19390658_ChIP-ChIP_HaCaT_Human0.69004613
132GATA3_26560356_Chip-Seq_TH2_Human0.68362553

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.79200615
2MP0002139_abnormal_hepatobiliary_system4.30148128
3MP0003806_abnormal_nucleotide_metabolis3.37676613
4MP0005365_abnormal_bile_salt3.10977011
5MP0003693_abnormal_embryo_hatching2.88869373
6MP0003646_muscle_fatigue2.78221521
7MP0005075_abnormal_melanosome_morpholog2.66832297
8MP0005085_abnormal_gallbladder_physiolo2.50386247
9MP0004957_abnormal_blastocyst_morpholog2.44499151
10MP0005451_abnormal_body_composition2.33610773
11MP0009840_abnormal_foam_cell2.27324095
12MP0003111_abnormal_nucleus_morphology2.26365867
13MP0005332_abnormal_amino_acid2.24778049
14MP0009333_abnormal_splenocyte_physiolog2.17707149
15MP0003077_abnormal_cell_cycle2.07857941
16MP0010094_abnormal_chromosome_stability2.04383470
17MP0009697_abnormal_copulation2.02131410
18MP0003763_abnormal_thymus_physiology2.00384470
19MP0008875_abnormal_xenobiotic_pharmacok1.99421811
20MP0006292_abnormal_olfactory_placode1.99150929
21MP0008877_abnormal_DNA_methylation1.96453697
22MP0003705_abnormal_hypodermis_morpholog1.88602195
23MP0003718_maternal_effect1.83538786
24MP0005671_abnormal_response_to1.79028496
25MP0004084_abnormal_cardiac_muscle1.67578007
26MP0001730_embryonic_growth_arrest1.67234553
27MP0004147_increased_porphyrin_level1.64098291
28MP0001661_extended_life_span1.59956202
29MP0006036_abnormal_mitochondrial_physio1.59566077
30MP0001986_abnormal_taste_sensitivity1.56439023
31MP0003252_abnormal_bile_duct1.55363169
32MP0005670_abnormal_white_adipose1.54854626
33MP0000372_irregular_coat_pigmentation1.53191993
34MP0003186_abnormal_redox_activity1.52594256
35MP0005083_abnormal_biliary_tract1.48956498
36MP0002163_abnormal_gland_morphology1.47880317
37MP0009643_abnormal_urine_homeostasis1.46893714
38MP0005645_abnormal_hypothalamus_physiol1.43854153
39MP0003221_abnormal_cardiomyocyte_apopto1.43684149
40MP0010329_abnormal_lipoprotein_level1.40658085
41MP0008995_early_reproductive_senescence1.39104724
42MP0002160_abnormal_reproductive_system1.38781122
43MP0004019_abnormal_vitamin_homeostasis1.38133701
44MP0001188_hyperpigmentation1.37265929
45MP0005319_abnormal_enzyme/_coenzyme1.36202411
46MP0008057_abnormal_DNA_replication1.34070636
47MP0000609_abnormal_liver_physiology1.29762027
48MP0001697_abnormal_embryo_size1.28582268
49MP0001873_stomach_inflammation1.28012548
50MP0002269_muscular_atrophy1.27051936
51MP0000703_abnormal_thymus_morphology1.27047323
52MP0001919_abnormal_reproductive_system1.26324419
53MP0003943_abnormal_hepatobiliary_system1.25535814
54MP0001672_abnormal_embryogenesis/_devel1.24815028
55MP0005380_embryogenesis_phenotype1.24815028
56MP0001666_abnormal_nutrient_absorption1.24133816
57MP0003984_embryonic_growth_retardation1.23736013
58MP0002088_abnormal_embryonic_growth/wei1.20990159
59MP0001145_abnormal_male_reproductive1.20709785
60MP0003656_abnormal_erythrocyte_physiolo1.19977186
61MP0002653_abnormal_ependyma_morphology1.19004308
62MP0005389_reproductive_system_phenotype1.18878781
63MP0005330_cardiomyopathy1.18397281
64MP0000350_abnormal_cell_proliferation1.14391359
65MP0000598_abnormal_liver_morphology1.14131072
66MP0000689_abnormal_spleen_morphology1.12297649
67MP0002837_dystrophic_cardiac_calcinosis1.12217003
68MP0000313_abnormal_cell_death1.11043499
69MP0008932_abnormal_embryonic_tissue1.09127669
70MP0008872_abnormal_physiological_respon1.08052896
71MP0002080_prenatal_lethality1.07450475
72MP0000750_abnormal_muscle_regeneration1.06850429
73MP0005666_abnormal_adipose_tissue1.06640873
74MP0005266_abnormal_metabolism1.06480206
75MP0002138_abnormal_hepatobiliary_system1.06431185
76MP0004036_abnormal_muscle_relaxation1.06390436
77MP0004043_abnormal_pH_regulation1.04865797
78MP0002396_abnormal_hematopoietic_system1.04736753
79MP0005395_other_phenotype1.04573589
80MP0002277_abnormal_respiratory_mucosa1.04497171
81MP0001529_abnormal_vocalization1.03657882
82MP0005551_abnormal_eye_electrophysiolog1.03096096
83MP0010030_abnormal_orbit_morphology1.02352089
84MP0005220_abnormal_exocrine_pancreas1.00930908
85MP0003195_calcinosis1.00424369
86MP0003698_abnormal_male_reproductive0.99354359
87MP0010368_abnormal_lymphatic_system0.98928501
88MP0006035_abnormal_mitochondrial_morpho0.97940895
89MP0002398_abnormal_bone_marrow0.97255867
90MP0000015_abnormal_ear_pigmentation0.96574585
91MP0002085_abnormal_embryonic_tissue0.96277646
92MP0002876_abnormal_thyroid_physiology0.95744906
93MP0008007_abnormal_cellular_replicative0.94797634
94MP0005636_abnormal_mineral_homeostasis0.94459973
95MP0009672_abnormal_birth_weight0.93775230
96MP0002118_abnormal_lipid_homeostasis0.91530521
97MP0002086_abnormal_extraembryonic_tissu0.91229515
98MP0002722_abnormal_immune_system0.91044803
99MP0003567_abnormal_fetal_cardiomyocyte0.90779875
100MP0001764_abnormal_homeostasis0.90240652
101MP0006138_congestive_heart_failure0.89851138
102MP0008058_abnormal_DNA_repair0.89807392
103MP0003123_paternal_imprinting0.89764639
104MP0001915_intracranial_hemorrhage0.89246220
105MP0002084_abnormal_developmental_patter0.88647394
106MP0001119_abnormal_female_reproductive0.87675868
107MP0010630_abnormal_cardiac_muscle0.87205377
108MP0000358_abnormal_cell_content/0.86618468
109MP0002102_abnormal_ear_morphology0.86527295
110MP0005253_abnormal_eye_physiology0.85815215
111MP0010352_gastrointestinal_tract_polyps0.84440760
112MP0010307_abnormal_tumor_latency0.83500885
113MP0002429_abnormal_blood_cell0.82290810
114MP0003699_abnormal_female_reproductive0.82181895
115MP0002136_abnormal_kidney_physiology0.81782001
116MP0002132_abnormal_respiratory_system0.81693102
117MP0004087_abnormal_muscle_fiber0.81437246
118MP0006054_spinal_hemorrhage0.80190619
119MP0000716_abnormal_immune_system0.80126289
120MP0004381_abnormal_hair_follicle0.78404104
121MP0004233_abnormal_muscle_weight0.76854652
122MP0002095_abnormal_skin_pigmentation0.76779131
123MP0001800_abnormal_humoral_immune0.76476107
124MP0006072_abnormal_retinal_apoptosis0.76090066
125MP0000647_abnormal_sebaceous_gland0.75954051
126MP0004215_abnormal_myocardial_fiber0.75786683
127MP0005584_abnormal_enzyme/coenzyme_acti0.75747988
128MP0001756_abnormal_urination0.75057227
129MP0008789_abnormal_olfactory_epithelium0.74952998
130MP0002019_abnormal_tumor_incidence0.74871039
131MP0001324_abnormal_eye_pigmentation0.74400674
132MP0002254_reproductive_system_inflammat0.73966588
133MP0000490_abnormal_crypts_of0.73536531
134MP0004185_abnormal_adipocyte_glucose0.73402697
135MP0002736_abnormal_nociception_after0.73265809
136MP0004142_abnormal_muscle_tone0.73079092
137MP0005385_cardiovascular_system_phenoty0.72639459
138MP0001544_abnormal_cardiovascular_syste0.72639459
139MP0000749_muscle_degeneration0.72392654
140MP0002420_abnormal_adaptive_immunity0.71911051
141MP0000653_abnormal_sex_gland0.71597060
142MP0001293_anophthalmia0.71492356
143MP0008775_abnormal_heart_ventricle0.71284619
144MP0003786_premature_aging0.71138293
145MP0005084_abnormal_gallbladder_morpholo0.71037457
146MP0001819_abnormal_immune_cell0.70824206
147MP0002723_abnormal_immune_serum0.70681299
148MP0004197_abnormal_fetal_growth/weight/0.70332066
149MP0009384_cardiac_valve_regurgitation0.69157201
150MP0000747_muscle_weakness0.69131398
151MP0002405_respiratory_system_inflammati0.68273119
152MP0003011_delayed_dark_adaptation0.68187825
153MP0001929_abnormal_gametogenesis0.67782118
154MP0002210_abnormal_sex_determination0.67041439
155MP0005410_abnormal_fertilization0.66940038
156MP0005646_abnormal_pituitary_gland0.66477056

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)4.69712026
2Gout (HP:0001997)4.60256390
3Abnormality of serine family amino acid metabolism (HP:0010894)4.18175691
4Abnormality of glycine metabolism (HP:0010895)4.18175691
5Ketosis (HP:0001946)3.95513901
6Hyperglycinemia (HP:0002154)3.87299947
7Hyperammonemia (HP:0001987)3.67583274
8Abnormality of fatty-acid metabolism (HP:0004359)3.66099826
9Ketoacidosis (HP:0001993)3.60415157
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.59791860
11Abnormality of aromatic amino acid family metabolism (HP:0004338)3.55734421
12Generalized aminoaciduria (HP:0002909)3.38443351
13Dicarboxylic aciduria (HP:0003215)3.35082680
14Abnormality of dicarboxylic acid metabolism (HP:0010995)3.35082680
15Deep venous thrombosis (HP:0002625)3.25936270
16Abnormality of sulfur amino acid metabolism (HP:0004339)3.21757279
17Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.21248486
18Intrahepatic cholestasis (HP:0001406)3.20410032
19Proximal tubulopathy (HP:0000114)3.15929243
20Hypoglycemic coma (HP:0001325)3.15085625
21Xanthomatosis (HP:0000991)3.11903517
22Increased purine levels (HP:0004368)3.09753183
23Hyperuricemia (HP:0002149)3.09753183
24Increased CSF lactate (HP:0002490)3.05348309
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.05338029
26Abnormality of purine metabolism (HP:0004352)3.04581322
27Abnormality of serum amino acid levels (HP:0003112)3.04485274
28Abnormal mitochondria in muscle tissue (HP:0008316)3.03413735
29Abnormal number of erythroid precursors (HP:0012131)3.03342401
30Increased serum lactate (HP:0002151)3.02641953
31Lipid accumulation in hepatocytes (HP:0006561)2.99822761
32Acute necrotizing encephalopathy (HP:0006965)2.99508823
33Retinal dysplasia (HP:0007973)2.99166882
34Acute encephalopathy (HP:0006846)2.97478369
35Hypobetalipoproteinemia (HP:0003563)2.93162778
363-Methylglutaconic aciduria (HP:0003535)2.92872101
37Mitochondrial inheritance (HP:0001427)2.92576368
38Abnormality of nucleobase metabolism (HP:0010932)2.92536459
39Oral leukoplakia (HP:0002745)2.85552600
40Type II lissencephaly (HP:0007260)2.84727661
41Abnormality of glutamine family amino acid metabolism (HP:0010902)2.80830483
42Rhabdomyolysis (HP:0003201)2.77399911
43Abnormal rod and cone electroretinograms (HP:0008323)2.74223365
44Abnormality of monocarboxylic acid metabolism (HP:0010996)2.73242330
45Abnormality of cells of the erythroid lineage (HP:0012130)2.72238457
46Lactic acidosis (HP:0003128)2.68954710
47Abnormality of pyrimidine metabolism (HP:0004353)2.68446734
48Increased hepatocellular lipid droplets (HP:0006565)2.66476890
49Abnormality of glycolysis (HP:0004366)2.66411202
50Increased serum pyruvate (HP:0003542)2.66411202
51Multiple enchondromatosis (HP:0005701)2.66237986
52Colon cancer (HP:0003003)2.60712458
53Lethargy (HP:0001254)2.59066331
54Chronic hepatic failure (HP:0100626)2.58561513
55Late onset (HP:0003584)2.58235214
56Megaloblastic anemia (HP:0001889)2.55925834
57Birth length less than 3rd percentile (HP:0003561)2.53143740
58Abnormal protein glycosylation (HP:0012346)2.51685084
59Abnormal glycosylation (HP:0012345)2.51685084
60Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.51685084
61Abnormal protein N-linked glycosylation (HP:0012347)2.51685084
62Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.50223680
63Metabolic acidosis (HP:0001942)2.46483822
64Hepatocellular necrosis (HP:0001404)2.44789506
65Myoglobinuria (HP:0002913)2.40270349
66Glycosuria (HP:0003076)2.38877681
67Abnormality of urine glucose concentration (HP:0011016)2.38877681
68Microvesicular hepatic steatosis (HP:0001414)2.37929942
69Abnormality of methionine metabolism (HP:0010901)2.37768181
70Progressive inability to walk (HP:0002505)2.36458074
71Increased intramyocellular lipid droplets (HP:0012240)2.33270197
72Hypolipoproteinemia (HP:0010981)2.33188015
73Type I transferrin isoform profile (HP:0003642)2.30291535
74Breast hypoplasia (HP:0003187)2.29987553
75Methylmalonic aciduria (HP:0012120)2.29512090
76Carpal bone hypoplasia (HP:0001498)2.29397136
77Abnormality of midbrain morphology (HP:0002418)2.28380567
78Molar tooth sign on MRI (HP:0002419)2.28380567
79Nausea (HP:0002018)2.27737613
80Abnormal cartilage morphology (HP:0002763)2.26510571
81Spastic diplegia (HP:0001264)2.24616565
82Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.23223255
83Decreased activity of mitochondrial respiratory chain (HP:0008972)2.23223255
84Pancreatic cysts (HP:0001737)2.22764219
85Pancytopenia (HP:0001876)2.22437921
86Abnormality of the labia minora (HP:0012880)2.20332672
87Metaphyseal cupping (HP:0003021)2.20013723
88Methylmalonic acidemia (HP:0002912)2.19496893
89Hyperbilirubinemia (HP:0002904)2.19085306
90Progressive macrocephaly (HP:0004481)2.18293841
91Malnutrition (HP:0004395)2.17955765
92Reticulocytopenia (HP:0001896)2.17947444
93Congenital stationary night blindness (HP:0007642)2.17459349
94Abnormal biliary tract physiology (HP:0012439)2.14748584
95Bile duct proliferation (HP:0001408)2.14748584
96Dynein arm defect of respiratory motile cilia (HP:0012255)2.13393413
97Absent/shortened dynein arms (HP:0200106)2.13393413
98Lissencephaly (HP:0001339)2.13371201
99IgG deficiency (HP:0004315)2.12695890
100True hermaphroditism (HP:0010459)2.12571418
101Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.11359963
102Delayed CNS myelination (HP:0002188)2.10579800
103Hyperlipoproteinemia (HP:0010980)2.08880879
104Constricted visual fields (HP:0001133)2.07127286
105Abnormality of the preputium (HP:0100587)2.04356554
106Abnormality of alanine metabolism (HP:0010916)2.03973279
107Hyperalaninemia (HP:0003348)2.03973279
108Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03973279
109Ragged-red muscle fibers (HP:0003200)2.02228372
110Hypoalphalipoproteinemia (HP:0003233)2.01280616
111Pancreatic fibrosis (HP:0100732)2.00383829
112Cerebral hypomyelination (HP:0006808)1.99430079
113Inability to walk (HP:0002540)1.98891661
114Absent thumb (HP:0009777)1.96964956
115Renal Fanconi syndrome (HP:0001994)1.96242610
116Horseshoe kidney (HP:0000085)1.96203995
117Testicular atrophy (HP:0000029)1.95859652
118Panhypogammaglobulinemia (HP:0003139)1.93461203
119Cerebral edema (HP:0002181)1.92055084
120Pendular nystagmus (HP:0012043)1.91619893
121CNS hypomyelination (HP:0003429)1.91001914
122Decreased electroretinogram (ERG) amplitude (HP:0000654)1.88643415
123Cleft eyelid (HP:0000625)1.88388372
124Muscle fiber splitting (HP:0003555)1.87755436
125Bony spicule pigmentary retinopathy (HP:0007737)1.87690326
126Hypoplasia of the uterus (HP:0000013)1.87230377
127Attenuation of retinal blood vessels (HP:0007843)1.86950257
128Progressive microcephaly (HP:0000253)1.86808770
129Optic disc pallor (HP:0000543)1.86687757
130Insulin resistance (HP:0000855)1.86636656
131Hepatic necrosis (HP:0002605)1.86625495
132Abnormality of DNA repair (HP:0003254)1.86610321
133Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86529420
134Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.86342947
135Optic nerve coloboma (HP:0000588)1.85725712
136Rough bone trabeculation (HP:0100670)1.84536584
137Sloping forehead (HP:0000340)1.83202829
138Exercise intolerance (HP:0003546)1.82992951
139Irritability (HP:0000737)1.82170903
140Type 2 muscle fiber atrophy (HP:0003554)1.81087039
141Polyuria (HP:0000103)1.80824564
142Severe muscular hypotonia (HP:0006829)1.80369510
143Vomiting (HP:0002013)1.79815533
144Respiratory difficulties (HP:0002880)1.78011824
145Degeneration of anterior horn cells (HP:0002398)1.77571966
146Abnormality of the anterior horn cell (HP:0006802)1.77571966
147Patellar aplasia (HP:0006443)1.77479555
148Hyperglycemia (HP:0003074)1.77464703
149Progressive muscle weakness (HP:0003323)1.77164416
150Abnormal gallbladder physiology (HP:0012438)1.76855184
151Cholecystitis (HP:0001082)1.76855184
152Cervical subluxation (HP:0003308)1.76839867
153Protrusio acetabuli (HP:0003179)1.75046865
154Male infertility (HP:0003251)1.74564669
155Brushfield spots (HP:0001088)1.74549632
156Abnormal urine output (HP:0012590)1.72414968
157Microretrognathia (HP:0000308)1.69060005
158Aplastic anemia (HP:0001915)1.67680548
159Increased muscle lipid content (HP:0009058)1.67273331
160Polycythemia (HP:0001901)1.67054591
161Abnormality of endocrine pancreas physiology (HP:0012093)1.65465319
162Abnormality of the pancreatic islet cells (HP:0006476)1.65465319
163Aplasia/Hypoplasia of the patella (HP:0006498)1.64730117
164Shawl scrotum (HP:0000049)1.64488473
165Fat malabsorption (HP:0002630)1.63953817
166Delayed epiphyseal ossification (HP:0002663)1.63614991
167Exercise-induced muscle cramps (HP:0003710)1.63560890
168Abnormality of transition element cation homeostasis (HP:0011030)1.62806126
169CNS demyelination (HP:0007305)1.62643357
170Secondary amenorrhea (HP:0000869)1.62225433
171Cholelithiasis (HP:0001081)1.61417190
172Hyperphosphaturia (HP:0003109)1.60257885
173Nephrolithiasis (HP:0000787)1.59024572
174Abnormality of the heme biosynthetic pathway (HP:0010472)1.57213777

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.95651492
2BCKDK3.85483622
3TRIB33.20708072
4STK162.99339523
5EEF2K2.90988415
6EIF2AK12.86649246
7NEK12.83298247
8WEE12.66638073
9STK38L2.61185852
10BUB12.56075385
11NUAK12.55655734
12TXK2.52218254
13CDC72.50609606
14PKN22.49041243
15TAF12.47056608
16NEK22.41018221
17ZAK2.40586182
18TTK2.28943092
19TRIM282.24598712
20BMPR1B2.16196874
21ACVR1B2.06060928
22LATS11.97536312
23PLK41.95011886
24MAP4K21.86927998
25TLK11.82840461
26ERN11.81205709
27PDK41.72293828
28PDK31.72293828
29LATS21.57035484
30BRSK21.56318814
31ERBB41.51701420
32IRAK41.45696566
33MAP3K101.43351004
34EIF2AK31.43302079
35STK101.36737452
36MAP3K81.35931149
37FLT31.32088894
38PBK1.30998336
39BRAF1.29731845
40PLK11.29260302
41WNK31.29232265
42CDK41.28972804
43NME21.24206965
44TESK21.20719693
45RPS6KB21.20703030
46AURKB1.19690765
47RPS6KA41.17638557
48FGFR41.16583068
49CHEK21.14325247
50MAPKAPK31.11302023
51FRK1.10206373
52LRRK21.09081907
53TTN1.08067146
54KSR21.07315853
55CDK71.07216793
56TEC1.07031551
57DYRK31.06926435
58TAOK11.06713435
59SCYL21.06070087
60WNK41.05652639
61PIM21.03491170
62TGFBR11.01886060
63MAPK111.00086443
64STK30.98758050
65MUSK0.98299892
66ADRBK20.96818267
67CSNK1G30.95803860
68PAK40.95179829
69TSSK60.94627828
70SIK10.93870163
71ITK0.91392084
72ATR0.91231504
73CSNK1G10.90846703
74CLK10.90647120
75NME10.90301012
76SMG10.90296993
77PASK0.89599819
78CDK190.87414388
79SIK30.86822492
80DAPK10.83390930
81AURKA0.80232592
82BRSK10.78594012
83MELK0.76993075
84ABL20.76610304
85KDR0.76325478
86IRAK10.74379181
87MARK30.72927104
88RAF10.72656119
89CSNK1A1L0.71983035
90EIF2AK20.70407286
91TYK20.69990280
92MTOR0.69786985
93STK40.69446822
94MAP3K60.69196779
95NLK0.69058509
96PRKCI0.68074055
97MAP4K10.67082995
98CCNB10.66988105
99MAP3K110.64166291
100RPS6KA50.63373876
101IKBKB0.63082853
102GRK10.63034088
103KSR10.62983717
104MAPK130.60914764
105PHKG10.59780706
106PHKG20.59780706
107CHEK10.58031688
108PDK20.56596901
109PLK30.56589879
110MAP2K30.56206523
111CSNK2A10.55255701
112PRKAA10.55195941
113SRPK10.55150014
114BTK0.54554426
115MST40.53259286
116JAK30.51691540
117CAMKK20.51300376
118CDK80.50724196
119MOS0.50379353
120CDK90.49815603
121CSNK1G20.49664923
122CSNK2A20.49418493
123MAP3K50.47975551
124BCR0.47574281
125MKNK10.47518925
126EPHA20.47116416
127TIE10.45451423
128MKNK20.45378590
129ILK0.43909700
130PAK10.43354142
131MAP2K70.43198112
132MAP3K30.43112571
133PIM10.42865967
134IKBKE0.42800514
135DYRK20.42421692
136LMTK20.42177852
137CDK120.41994505
138PRKCQ0.41415086
139AKT20.40729944
140OBSCN0.40478847
141TAOK30.40318353
142CDK20.39225690
143INSRR0.37887665
144AKT30.37427217
145GRK60.35470236
146CDK10.35063067
147CDK60.34585051
148ZAP700.32009189
149ATM0.31404966
150VRK10.31168376
151PTK60.30907093
152PTK20.30691115
153PRKAA20.30674361
154PINK10.28457214
155NEK90.27148647

Predicted pathways (KEGG)

RankGene SetZ-score
1Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.87970495
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.80735875
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.51768294
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.45082121
5DNA replication_Homo sapiens_hsa030302.41934610
6Propanoate metabolism_Homo sapiens_hsa006402.33523793
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31146439
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.30429452
9One carbon pool by folate_Homo sapiens_hsa006702.30290372
10Fatty acid degradation_Homo sapiens_hsa000712.29529978
11Selenocompound metabolism_Homo sapiens_hsa004502.07522503
12Biosynthesis of amino acids_Homo sapiens_hsa012302.06953452
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.05756361
14Carbon metabolism_Homo sapiens_hsa012002.04113667
15Oxidative phosphorylation_Homo sapiens_hsa001902.02230960
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01707297
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.99473586
18Pyruvate metabolism_Homo sapiens_hsa006201.92745911
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.90540978
20Butanoate metabolism_Homo sapiens_hsa006501.90247230
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.86183985
22Mismatch repair_Homo sapiens_hsa034301.84189588
23Parkinsons disease_Homo sapiens_hsa050121.81088721
24Fatty acid metabolism_Homo sapiens_hsa012121.80460080
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.73331302
26Primary immunodeficiency_Homo sapiens_hsa053401.71150759
27Folate biosynthesis_Homo sapiens_hsa007901.70724018
28Vitamin B6 metabolism_Homo sapiens_hsa007501.70135224
29Protein export_Homo sapiens_hsa030601.68450192
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67061701
31Tryptophan metabolism_Homo sapiens_hsa003801.66938540
32Peroxisome_Homo sapiens_hsa041461.60973075
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.51738141
34Arginine biosynthesis_Homo sapiens_hsa002201.51676875
35RNA transport_Homo sapiens_hsa030131.51270028
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49582465
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.49146335
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.45732356
39Cell cycle_Homo sapiens_hsa041101.45503935
40Huntingtons disease_Homo sapiens_hsa050161.39831835
41Base excision repair_Homo sapiens_hsa034101.39587644
42RNA polymerase_Homo sapiens_hsa030201.39114255
43Pentose phosphate pathway_Homo sapiens_hsa000301.34253159
44Pyrimidine metabolism_Homo sapiens_hsa002401.32319934
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30276453
46Sulfur relay system_Homo sapiens_hsa041221.29111802
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.28474223
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23511111
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22601324
50beta-Alanine metabolism_Homo sapiens_hsa004101.21092658
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18653036
52Nitrogen metabolism_Homo sapiens_hsa009101.15976077
53Arginine and proline metabolism_Homo sapiens_hsa003301.10874905
54PPAR signaling pathway_Homo sapiens_hsa033201.09962275
55Glutathione metabolism_Homo sapiens_hsa004801.06382406
56Lysine degradation_Homo sapiens_hsa003101.06234877
57Homologous recombination_Homo sapiens_hsa034401.05500330
58Proteasome_Homo sapiens_hsa030501.05258990
59Nucleotide excision repair_Homo sapiens_hsa034201.00269529
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97725371
61Vitamin digestion and absorption_Homo sapiens_hsa049770.94426281
62RNA degradation_Homo sapiens_hsa030180.94241682
63Starch and sucrose metabolism_Homo sapiens_hsa005000.94141564
64Fructose and mannose metabolism_Homo sapiens_hsa000510.94116577
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91313540
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90965618
67Spliceosome_Homo sapiens_hsa030400.89425344
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88907006
69Regulation of autophagy_Homo sapiens_hsa041400.83590337
70Galactose metabolism_Homo sapiens_hsa000520.82920965
71Alzheimers disease_Homo sapiens_hsa050100.79987723
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78324982
73Fatty acid elongation_Homo sapiens_hsa000620.75260752
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71372368
75Complement and coagulation cascades_Homo sapiens_hsa046100.70159324
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70109507
77Phototransduction_Homo sapiens_hsa047440.70108906
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66521889
79Fat digestion and absorption_Homo sapiens_hsa049750.66442646
80Chemical carcinogenesis_Homo sapiens_hsa052040.63192062
81Histidine metabolism_Homo sapiens_hsa003400.63014853
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63000769
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.61553700
84Basal transcription factors_Homo sapiens_hsa030220.60861045
85p53 signaling pathway_Homo sapiens_hsa041150.58964137
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58179472
87Purine metabolism_Homo sapiens_hsa002300.57163983
88Linoleic acid metabolism_Homo sapiens_hsa005910.57133591
89Metabolic pathways_Homo sapiens_hsa011000.56908240
90Retinol metabolism_Homo sapiens_hsa008300.56416722
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.55018460
92Bile secretion_Homo sapiens_hsa049760.53885286
93Phenylalanine metabolism_Homo sapiens_hsa003600.53504117
94Sulfur metabolism_Homo sapiens_hsa009200.53248543
95Glycerolipid metabolism_Homo sapiens_hsa005610.51497916
96N-Glycan biosynthesis_Homo sapiens_hsa005100.48334767
97Steroid biosynthesis_Homo sapiens_hsa001000.43135320
98Caffeine metabolism_Homo sapiens_hsa002320.43045438
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42369710
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.42097746
101Fanconi anemia pathway_Homo sapiens_hsa034600.40787406
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37939109
103Bladder cancer_Homo sapiens_hsa052190.37914152
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37813684
105Collecting duct acid secretion_Homo sapiens_hsa049660.36813545
106Small cell lung cancer_Homo sapiens_hsa052220.35552660
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.35548417
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34962954
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34744691
110Circadian rhythm_Homo sapiens_hsa047100.34386120
111mRNA surveillance pathway_Homo sapiens_hsa030150.33337965
112Tyrosine metabolism_Homo sapiens_hsa003500.32818809
113Ribosome_Homo sapiens_hsa030100.31000516
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28439359
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25213649
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25138473
117AMPK signaling pathway_Homo sapiens_hsa041520.24790401
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21097079
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20824434
120Epstein-Barr virus infection_Homo sapiens_hsa051690.20530034
121Other glycan degradation_Homo sapiens_hsa005110.20518508
122Cardiac muscle contraction_Homo sapiens_hsa042600.20399062
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19393863
124Ether lipid metabolism_Homo sapiens_hsa005650.19272606
125Arachidonic acid metabolism_Homo sapiens_hsa005900.19173051
126Herpes simplex infection_Homo sapiens_hsa051680.19099206
127Non-homologous end-joining_Homo sapiens_hsa034500.17811505

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