UBE4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.81079235
2glucocorticoid receptor signaling pathway (GO:0042921)4.56680858
3regulation of RNA export from nucleus (GO:0046831)4.25818365
4nuclear pore organization (GO:0006999)4.17448745
5nuclear pore complex assembly (GO:0051292)4.07687358
6mitotic sister chromatid cohesion (GO:0007064)4.04329706
7corticosteroid receptor signaling pathway (GO:0031958)3.91748354
8paraxial mesoderm development (GO:0048339)3.89757584
9hippo signaling (GO:0035329)3.85018471
10cytoplasmic mRNA processing body assembly (GO:0033962)3.70802891
11peptidyl-lysine dimethylation (GO:0018027)3.70556820
12heterochromatin organization (GO:0070828)3.68329403
13negative regulation of histone methylation (GO:0031061)3.66028104
14regulation of NFAT protein import into nucleus (GO:0051532)3.60681160
15regulation of nucleobase-containing compound transport (GO:0032239)3.59251402
16cellular protein complex localization (GO:0034629)3.58081475
17protein complex localization (GO:0031503)3.54314852
18histone H2A monoubiquitination (GO:0035518)3.52718849
19gene silencing by RNA (GO:0031047)3.44992820
20regulation of sister chromatid cohesion (GO:0007063)3.15593315
21gene silencing (GO:0016458)3.12965642
22mitotic nuclear envelope disassembly (GO:0007077)3.12456623
23NLS-bearing protein import into nucleus (GO:0006607)3.11692699
24adherens junction assembly (GO:0034333)3.06731914
25membrane disassembly (GO:0030397)3.06555862
26nuclear envelope disassembly (GO:0051081)3.06555862
27desmosome organization (GO:0002934)3.05543342
28nucleosome disassembly (GO:0006337)3.04627146
29protein-DNA complex disassembly (GO:0032986)3.04627146
30stress granule assembly (GO:0034063)3.03379159
31regulation of translational fidelity (GO:0006450)3.03263403
32mitotic chromosome condensation (GO:0007076)2.98279449
33focal adhesion assembly (GO:0048041)2.98031560
34cell-substrate adherens junction assembly (GO:0007045)2.98031560
35sister chromatid segregation (GO:0000819)2.96767198
36protein localization to kinetochore (GO:0034501)2.95781530
37regulation of hippo signaling (GO:0035330)2.92525132
38layer formation in cerebral cortex (GO:0021819)2.92307079
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.92002975
40intracellular estrogen receptor signaling pathway (GO:0030520)2.90329088
41bundle of His cell to Purkinje myocyte communication (GO:0086069)2.89844351
42notochord development (GO:0030903)2.89416171
43polarized epithelial cell differentiation (GO:0030859)2.88511697
44regulation of clathrin-mediated endocytosis (GO:2000369)2.83970823
45regulation of gene silencing by RNA (GO:0060966)2.83571296
46regulation of posttranscriptional gene silencing (GO:0060147)2.83571296
47regulation of gene silencing by miRNA (GO:0060964)2.83571296
48regulation of translational termination (GO:0006449)2.81399164
49convergent extension (GO:0060026)2.80457672
50mitotic sister chromatid segregation (GO:0000070)2.79709139
51DNA unwinding involved in DNA replication (GO:0006268)2.79110694
52protein export from nucleus (GO:0006611)2.78797760
53cell migration in hindbrain (GO:0021535)2.77425530
54peptidyl-arginine methylation (GO:0018216)2.74374910
55peptidyl-arginine N-methylation (GO:0035246)2.74374910
56negative regulation of potassium ion transmembrane transport (GO:1901380)2.74366997
57protein localization to microtubule (GO:0035372)2.74044660
583-UTR-mediated mRNA stabilization (GO:0070935)2.72380860
59peptidyl-arginine omega-N-methylation (GO:0035247)2.71887248
60embryonic foregut morphogenesis (GO:0048617)2.69006441
61histone lysine demethylation (GO:0070076)2.67531209
62positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.66455857
63histone H3-K4 methylation (GO:0051568)2.65802943
64histone H4-K16 acetylation (GO:0043984)2.64979160
65insulin-like growth factor receptor signaling pathway (GO:0048009)2.64686051
66negative regulation of circadian rhythm (GO:0042754)2.62126751
67protein localization to chromosome (GO:0034502)2.61713106
68negative regulation of DNA repair (GO:0045738)2.61566452
69negative regulation of cell size (GO:0045792)2.61516828
70regulation of histone H3-K9 methylation (GO:0051570)2.61279387
71regulation of mitotic spindle organization (GO:0060236)2.60797610
72embryonic camera-type eye morphogenesis (GO:0048596)2.60334782
73pore complex assembly (GO:0046931)2.59472105
74spliceosomal tri-snRNP complex assembly (GO:0000244)2.58410388
75negative regulation of histone modification (GO:0031057)2.58224033
76mRNA stabilization (GO:0048255)2.55508835
77RNA stabilization (GO:0043489)2.55508835
78positive regulation of chromosome segregation (GO:0051984)2.55138825
79cell communication by electrical coupling (GO:0010644)2.54842584
80positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.54733185
81positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.54733185
82positive regulation of mitotic sister chromatid separation (GO:1901970)2.54733185
83cell-substrate junction assembly (GO:0007044)2.54309398
84nuclear envelope organization (GO:0006998)2.54073146
85histone H2B ubiquitination (GO:0033523)2.53932774
86DNA duplex unwinding (GO:0032508)2.52884468
87trophectodermal cell differentiation (GO:0001829)2.52057781
88positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.52018645
89peptidyl-threonine phosphorylation (GO:0018107)2.51354738
90negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.50617178
91histone H4-K12 acetylation (GO:0043983)2.50426946
92embryonic retina morphogenesis in camera-type eye (GO:0060059)2.50059642
93gastrulation with mouth forming second (GO:0001702)2.50032868
94histone demethylation (GO:0016577)2.49858859
95monoubiquitinated protein deubiquitination (GO:0035520)2.49540027
96histone lysine methylation (GO:0034968)2.48987450
97histone H3-K9 methylation (GO:0051567)2.48683343
98gap junction assembly (GO:0016264)2.48139074
99peptidyl-threonine modification (GO:0018210)2.48033523
100maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.48012759
101chromatin silencing (GO:0006342)2.47758681
102histone H3-K36 demethylation (GO:0070544)2.47210831
103DNA methylation (GO:0006306)2.47006127
104DNA alkylation (GO:0006305)2.47006127
105piRNA metabolic process (GO:0034587)2.46797884
106histone H4-K5 acetylation (GO:0043981)2.46029571
107histone H4-K8 acetylation (GO:0043982)2.46029571
108folic acid-containing compound biosynthetic process (GO:0009396)2.45914477
109regulation of establishment of planar polarity (GO:0090175)2.45229153
110regulation of spindle organization (GO:0090224)2.45224702
111positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.45049354
112positive regulation of cell cycle G2/M phase transition (GO:1902751)2.45049354
113protein demethylation (GO:0006482)2.45023427
114protein dealkylation (GO:0008214)2.45023427
115histone H3-K9 demethylation (GO:0033169)2.44990982
116adult heart development (GO:0007512)2.44988387
117neural tube development (GO:0021915)2.44761155
118positive regulation of RNA splicing (GO:0033120)2.44069035
119cardiac myofibril assembly (GO:0055003)2.43205813
120cytoskeletal anchoring at plasma membrane (GO:0007016)2.42514094
121protein localization to chromosome, centromeric region (GO:0071459)2.42051785
122embryonic eye morphogenesis (GO:0048048)2.40190803
123Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.39739253
124protein retention in ER lumen (GO:0006621)2.39581830
125histone methylation (GO:0016571)2.39298039
126regulation of stem cell maintenance (GO:2000036)2.38951010
127planar cell polarity pathway involved in neural tube closure (GO:0090179)2.38384930
128regulation of histone H3-K27 methylation (GO:0061085)2.38088266
129chromatin assembly (GO:0031497)2.37982990
130histone H4 acetylation (GO:0043967)2.37860490
131positive regulation of SMAD protein import into nucleus (GO:0060391)2.36854381
132establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.36687387
133sodium ion export (GO:0071436)2.36072577
134nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.36013347
135regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.35896184
136body morphogenesis (GO:0010171)2.34896617
137regulation of mRNA stability (GO:0043488)2.34830818
138DNA geometric change (GO:0032392)2.34507177
139plasma membrane repair (GO:0001778)2.34218395
140establishment of nucleus localization (GO:0040023)2.33773316
141negative regulation of vascular permeability (GO:0043116)2.33756715
142negative regulation of fibroblast apoptotic process (GO:2000270)2.33623890
143peripheral nervous system axon ensheathment (GO:0032292)2.33303999
144myelination in peripheral nervous system (GO:0022011)2.33303999
145IMP metabolic process (GO:0046040)2.31369383
146eye morphogenesis (GO:0048592)2.30454085
147morphogenesis of an epithelial sheet (GO:0002011)2.28133096
148negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.27757329
149negative regulation of translation, ncRNA-mediated (GO:0040033)2.27757329
150regulation of translation, ncRNA-mediated (GO:0045974)2.27757329
151COPII vesicle coating (GO:0048208)2.27114680
152N-terminal protein amino acid acetylation (GO:0006474)2.25520374
153response to epidermal growth factor (GO:0070849)2.21370028
154regulation of chromatin binding (GO:0035561)2.20816429
155retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.20290448
156camera-type eye morphogenesis (GO:0048593)2.18800328
157positive regulation of protein export from nucleus (GO:0046827)2.15450002

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.26124852
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.82855024
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.83692090
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.05330505
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.72334186
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.66909086
7TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.60478042
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.57473456
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.54800861
10MYC_22102868_ChIP-Seq_BL_Human2.50458577
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.46304358
12* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.46048268
13SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.44514328
14DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.31617932
15CLOCK_20551151_ChIP-Seq_293T_Human2.30382638
16ZFP281_27345836_Chip-Seq_ESCs_Mouse2.24688267
17SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.20794401
18WT1_19549856_ChIP-ChIP_CCG9911_Human2.20468282
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.15731388
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.14628959
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.04650475
22ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.98173576
23* KDM2B_26808549_Chip-Seq_DND41_Human1.96013494
24PKCTHETA_26484144_Chip-Seq_BREAST_Human1.91710199
25* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.87896161
26CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.87048780
27AR_21909140_ChIP-Seq_LNCAP_Human1.86439490
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.86389044
29FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.84613649
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.81410879
31KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.81410879
32KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.81410879
33KDM2B_26808549_Chip-Seq_K562_Human1.79655929
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.78705016
35* KDM2B_26808549_Chip-Seq_JURKAT_Human1.73845488
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70354989
37TCF7_22412390_ChIP-Seq_EML_Mouse1.70140342
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67635865
39ESR1_15608294_ChIP-ChIP_MCF-7_Human1.63514355
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63380536
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60934181
42* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.59649634
43ISL1_27105846_Chip-Seq_CPCs_Mouse1.58582473
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.57290659
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56353067
46NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.54662364
47RARB_27405468_Chip-Seq_BRAIN_Mouse1.53278525
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52080042
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.51214675
50NANOG_21062744_ChIP-ChIP_HESCs_Human1.48736468
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.47800840
52NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.45522529
53SOX9_24532713_ChIP-Seq_HFSC_Mouse1.45047226
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43201935
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.41642933
56MYC_18555785_ChIP-Seq_MESCs_Mouse1.40386062
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.39248994
58EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.38179966
59NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.36357172
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.35967828
61CIITA_25753668_ChIP-Seq_RAJI_Human1.35691271
62* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34366074
63EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33182635
64* CREB1_26743006_Chip-Seq_LNCaP_Human1.32951427
65* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31322716
66CHD1_26751641_Chip-Seq_LNCaP_Human1.29954217
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29764415
68TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26567934
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25890347
70* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25341587
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24588433
72TBX20_22328084_ChIP-Seq_HEART_Mouse1.18921072
73TBX20_22080862_ChIP-Seq_HEART_Mouse1.18921072
74BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18511660
75CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17640516
76POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.13993242
77PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13273481
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11748486
79TBX3_20139965_ChIP-Seq_ESCs_Mouse1.10958314
80TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10750472
81* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10517947
82TP53_16413492_ChIP-PET_HCT116_Human1.10123543
83HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10104312
84* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10040106
85* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.07692852
86ATF3_27146783_Chip-Seq_COLON_Human1.07671064
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07391870
88EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07161698
89RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06390619
90TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.05993541
91TCF3_18692474_ChIP-Seq_MESCs_Mouse1.05765078
92* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05283508
93GATA4_21415370_ChIP-Seq_HL-1_Mouse1.05181514
94SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.05133670
95AR_19668381_ChIP-Seq_PC3_Human1.04932510
96* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04042717
97SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02823177
98* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02127895
99ZNF263_19887448_ChIP-Seq_K562_Human1.01609659
100* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00267358
101* FOXA2_19822575_ChIP-Seq_HepG2_Human0.99740218
102NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99286178
103NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98481082
104* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98467862
105SOX17_20123909_ChIP-Seq_XEN_Mouse0.98452805
106KDM5A_27292631_Chip-Seq_BREAST_Human0.98301019
107SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97341903
108* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.97302090
109EP300_21415370_ChIP-Seq_HL-1_Mouse0.96192778
110GATA1_26923725_Chip-Seq_HPCs_Mouse0.96150730
111TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.96113406
112TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96112561
113* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95984835
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95215658
115* ELK3_25401928_ChIP-Seq_HUVEC_Human0.95094574
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94968370
117MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94525010
118ZNF274_21170338_ChIP-Seq_K562_Hela0.93978434
119GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.92648910
120RUNX1_27514584_Chip-Seq_MCF-7_Human0.92196091
121* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92052105
122RING1B_27294783_Chip-Seq_NPCs_Mouse0.91509375
123GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90973603
124SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.90567049
125SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89686609
126EZH2_22144423_ChIP-Seq_EOC_Human0.88307165
127DROSHA_22980978_ChIP-Seq_HELA_Human0.87685467
128* RACK7_27058665_Chip-Seq_MCF-7_Human0.87286842
129SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86258317
130CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.86190563
131VDR_21846776_ChIP-Seq_THP-1_Human0.85887000
132GATA6_25053715_ChIP-Seq_YYC3_Human0.85390368

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting3.05264242
2MP0008877_abnormal_DNA_methylation2.97441113
3MP0003705_abnormal_hypodermis_morpholog2.89766266
4MP0005076_abnormal_cell_differentiation2.83209110
5MP0003941_abnormal_skin_development2.74472497
6MP0003121_genomic_imprinting2.61205866
7MP0003122_maternal_imprinting2.56826203
8MP0000569_abnormal_digit_pigmentation2.44158118
9MP0010352_gastrointestinal_tract_polyps2.25111009
10MP0004233_abnormal_muscle_weight2.21666235
11MP0002653_abnormal_ependyma_morphology2.17081767
12MP0010030_abnormal_orbit_morphology2.14394638
13MP0003890_abnormal_embryonic-extraembry2.09100481
14MP0000537_abnormal_urethra_morphology2.06636278
15MP0002084_abnormal_developmental_patter2.03948655
16MP0001730_embryonic_growth_arrest2.02957248
17MP0003111_abnormal_nucleus_morphology1.98792664
18MP0009780_abnormal_chondrocyte_physiolo1.98525928
19MP0008438_abnormal_cutaneous_collagen1.94758060
20MP0004859_abnormal_synaptic_plasticity1.92574768
21MP0000566_synostosis1.92567835
22MP0003787_abnormal_imprinting1.92043953
23MP0002796_impaired_skin_barrier1.87293850
24MP0002085_abnormal_embryonic_tissue1.79188592
25MP0000751_myopathy1.78773877
26MP0005623_abnormal_meninges_morphology1.78189869
27MP0003283_abnormal_digestive_organ1.75781870
28MP0001849_ear_inflammation1.72383016
29MP0003119_abnormal_digestive_system1.71765007
30MP0005275_abnormal_skin_tensile1.70753465
31MP0008961_abnormal_basal_metabolism1.68918746
32MP0005380_embryogenesis_phenotype1.65892991
33MP0001672_abnormal_embryogenesis/_devel1.65892991
34MP0001697_abnormal_embryo_size1.64797365
35MP0004272_abnormal_basement_membrane1.64272896
36MP0003984_embryonic_growth_retardation1.63957131
37MP0000428_abnormal_craniofacial_morphol1.62741790
38MP0009672_abnormal_birth_weight1.61901452
39MP0004197_abnormal_fetal_growth/weight/1.61620615
40MP0000350_abnormal_cell_proliferation1.61359147
41MP0002088_abnormal_embryonic_growth/wei1.61098331
42MP0002009_preneoplasia1.59448987
43MP0003077_abnormal_cell_cycle1.58802669
44MP0005187_abnormal_penis_morphology1.57923894
45MP0004084_abnormal_cardiac_muscle1.51913471
46MP0009053_abnormal_anal_canal1.50039140
47MP0010307_abnormal_tumor_latency1.49964042
48MP0003861_abnormal_nervous_system1.49357064
49MP0005409_darkened_coat_color1.49000288
50* MP0010630_abnormal_cardiac_muscle1.47133913
51MP0010234_abnormal_vibrissa_follicle1.46465015
52MP0008932_abnormal_embryonic_tissue1.45218166
53MP0004957_abnormal_blastocyst_morpholog1.45080741
54MP0000579_abnormal_nail_morphology1.43490873
55MP0002086_abnormal_extraembryonic_tissu1.43342514
56MP0009703_decreased_birth_body1.43240602
57MP0004036_abnormal_muscle_relaxation1.43163543
58MP0010094_abnormal_chromosome_stability1.42335950
59* MP0004087_abnormal_muscle_fiber1.41670783
60MP0002877_abnormal_melanocyte_morpholog1.39458008
61MP0004264_abnormal_extraembryonic_tissu1.36981605
62MP0003646_muscle_fatigue1.36887724
63MP0001348_abnormal_lacrimal_gland1.35508199
64MP0000733_abnormal_muscle_development1.34349146
65MP0003385_abnormal_body_wall1.33541326
66MP0003935_abnormal_craniofacial_develop1.31926949
67MP0003115_abnormal_respiratory_system1.30955505
68MP0000534_abnormal_ureter_morphology1.28763975
69MP0005451_abnormal_body_composition1.27207480
70MP0004185_abnormal_adipocyte_glucose1.26430501
71MP0003937_abnormal_limbs/digits/tail_de1.24424671
72MP0004858_abnormal_nervous_system1.23011765
73* MP0002080_prenatal_lethality1.20378048
74MP0005257_abnormal_intraocular_pressure1.20161118
75MP0001299_abnormal_eye_distance/1.18793731
76MP0003942_abnormal_urinary_system1.17978449
77MP0005501_abnormal_skin_physiology1.17533506
78MP0003567_abnormal_fetal_cardiomyocyte1.15381308
79MP0000750_abnormal_muscle_regeneration1.13954197
80MP0000759_abnormal_skeletal_muscle1.13207832
81MP0003755_abnormal_palate_morphology1.10990917
82MP0002269_muscular_atrophy1.07513101
83* MP0006138_congestive_heart_failure1.06710055
84MP0002925_abnormal_cardiovascular_devel1.05682783
85MP0004270_analgesia1.04401945
86MP0000747_muscle_weakness1.03718670
87* MP0002152_abnormal_brain_morphology1.03348175
88MP0001661_extended_life_span1.02254839
89MP0004145_abnormal_muscle_electrophysio1.01268749
90MP0002106_abnormal_muscle_physiology1.00730353
91MP0008057_abnormal_DNA_replication1.00290239
92MP0003566_abnormal_cell_adhesion1.00082503
93MP0003635_abnormal_synaptic_transmissio0.99246675
94MP0002108_abnormal_muscle_morphology0.98527671
95MP0000749_muscle_degeneration0.97852680
96* MP0001915_intracranial_hemorrhage0.97665543
97MP0003693_abnormal_embryo_hatching0.97535744
98MP0004134_abnormal_chest_morphology0.95598943
99MP0000432_abnormal_head_morphology0.95385915
100MP0002234_abnormal_pharynx_morphology0.95130754
101MP0000762_abnormal_tongue_morphology0.94991016
102MP0002060_abnormal_skin_morphology0.94621701
103MP0002116_abnormal_craniofacial_bone0.94449478
104MP0005248_abnormal_Harderian_gland0.94169495
105MP0002697_abnormal_eye_size0.94120666
106MP0000778_abnormal_nervous_system0.93890229
107MP0000003_abnormal_adipose_tissue0.93851125
108MP0005369_muscle_phenotype0.92973013
109MP0002089_abnormal_postnatal_growth/wei0.92664734
110MP0009384_cardiac_valve_regurgitation0.92648778
111MP0004885_abnormal_endolymph0.90878903
112MP0002396_abnormal_hematopoietic_system0.89197326
113MP0004811_abnormal_neuron_physiology0.89129167
114MP0002092_abnormal_eye_morphology0.87058936
115MP0000955_abnormal_spinal_cord0.86592661
116MP0008007_abnormal_cellular_replicative0.86532549
117MP0002249_abnormal_larynx_morphology0.85974447
118MP0001286_abnormal_eye_development0.85161056
119MP0000462_abnormal_digestive_system0.84268589
120MP0002081_perinatal_lethality0.83684273
121MP0001293_anophthalmia0.82297792
122MP0008770_decreased_survivor_rate0.81718034
123MP0009278_abnormal_bone_marrow0.79799666
124MP0002063_abnormal_learning/memory/cond0.78936845
125* MP0000266_abnormal_heart_morphology0.78727932
126MP0002233_abnormal_nose_morphology0.77441911
127MP0002184_abnormal_innervation0.76694540
128MP0005375_adipose_tissue_phenotype0.76589451
129MP0005423_abnormal_somatic_nervous0.75182207
130MP0002932_abnormal_joint_morphology0.74020152
131MP0002111_abnormal_tail_morphology0.73995025
132MP0005666_abnormal_adipose_tissue0.73698446
133MP0003091_abnormal_cell_migration0.73339895
134MP0002114_abnormal_axial_skeleton0.72412514
135MP0003300_gastrointestinal_ulcer0.69239262
136MP0002909_abnormal_adrenal_gland0.68769035
137MP0003868_abnormal_feces_composition0.66848444

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.25054073
2Abnormality of the astrocytes (HP:0100707)3.21708745
3Astrocytoma (HP:0009592)3.21708745
4Ependymoma (HP:0002888)3.18456718
5Hyperacusis (HP:0010780)3.07565235
6Increased nuchal translucency (HP:0010880)3.04713938
7Macroorchidism (HP:0000053)2.91128782
8Abnormality of the fingertips (HP:0001211)2.89065186
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.87960526
10Short 4th metacarpal (HP:0010044)2.87960526
11Heterotopia (HP:0002282)2.86016491
12Renal duplication (HP:0000075)2.73978980
13Right ventricular cardiomyopathy (HP:0011663)2.68337619
14Papillary thyroid carcinoma (HP:0002895)2.56187486
15Shallow orbits (HP:0000586)2.55016999
16Abnormality of the lower motor neuron (HP:0002366)2.53963199
17Renovascular hypertension (HP:0100817)2.52288208
18Elfin facies (HP:0004428)2.51507009
19Obsessive-compulsive behavior (HP:0000722)2.50427679
20Centrally nucleated skeletal muscle fibers (HP:0003687)2.49605468
21Genetic anticipation (HP:0003743)2.49578346
22Trigonocephaly (HP:0000243)2.38753392
23Facial hemangioma (HP:0000329)2.38169173
24Long eyelashes (HP:0000527)2.36165732
25Glioma (HP:0009733)2.32868712
26Pointed chin (HP:0000307)2.32629548
27Selective tooth agenesis (HP:0001592)2.32453486
28Sacral dimple (HP:0000960)2.30697522
29Pseudobulbar signs (HP:0002200)2.30243970
30Truncal obesity (HP:0001956)2.29772911
31Narrow palate (HP:0000189)2.29492317
32Difficulty running (HP:0009046)2.27002013
33Abnormality of the 4th metacarpal (HP:0010012)2.26267538
34Increased connective tissue (HP:0009025)2.26245569
35Broad thumb (HP:0011304)2.24635613
36Aplasia involving bones of the upper limbs (HP:0009823)2.24094762
37Aplasia of the phalanges of the hand (HP:0009802)2.24094762
38Aplasia involving bones of the extremities (HP:0009825)2.24094762
39Insomnia (HP:0100785)2.24088914
40Disproportionate tall stature (HP:0001519)2.20160220
41Advanced eruption of teeth (HP:0006288)2.18912119
42Neoplasm of the oral cavity (HP:0100649)2.18318030
43Sparse lateral eyebrow (HP:0005338)2.15484888
44Neoplasm of the heart (HP:0100544)2.12116177
45Overriding aorta (HP:0002623)2.10045043
46Bowel diverticulosis (HP:0005222)2.09270632
47Termporal pattern (HP:0011008)2.07972805
48Insidious onset (HP:0003587)2.07972805
49Abnormality of the salivary glands (HP:0010286)2.07039882
50Proximal placement of thumb (HP:0009623)2.06917896
51Osteolytic defects of the phalanges of the hand (HP:0009771)2.05532979
52Osteolytic defects of the hand bones (HP:0009699)2.05532979
53Abnormality of the distal phalanx of the thumb (HP:0009617)2.05460883
54Medulloblastoma (HP:0002885)2.05045028
55Dysmetric saccades (HP:0000641)2.05004269
56Deviation of the thumb (HP:0009603)2.04701682
57Type 1 muscle fiber predominance (HP:0003803)2.04294554
58Lower limb amyotrophy (HP:0007210)2.02702946
59Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.02631455
60Abnormality of the labia minora (HP:0012880)2.01936911
61Enlarged penis (HP:0000040)1.98787502
62Fibrous tissue neoplasm (HP:0012316)1.97993025
63Shawl scrotum (HP:0000049)1.97325814
64Subacute progressive viral hepatitis (HP:0006572)1.96670415
65Abnormality of the diencephalon (HP:0010662)1.96305323
66High anterior hairline (HP:0009890)1.95694642
67Fibroma (HP:0010614)1.95506445
68Overgrowth (HP:0001548)1.95499187
69Attention deficit hyperactivity disorder (HP:0007018)1.93630900
70Bowel incontinence (HP:0002607)1.92433143
71Genu recurvatum (HP:0002816)1.91245495
72Neoplasm of striated muscle (HP:0009728)1.90457748
73Exercise-induced muscle cramps (HP:0003710)1.88980336
74Long palpebral fissure (HP:0000637)1.88852427
75Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.88728053
76Nemaline bodies (HP:0003798)1.88595668
77Distal lower limb amyotrophy (HP:0008944)1.87921804
78Cerebral aneurysm (HP:0004944)1.87490843
79Gastrointestinal carcinoma (HP:0002672)1.86050299
80Malignant gastrointestinal tract tumors (HP:0006749)1.86050299
81Spinal rigidity (HP:0003306)1.85460614
82Premature rupture of membranes (HP:0001788)1.84641753
83Muscle fiber inclusion bodies (HP:0100299)1.83769047
84Protrusio acetabuli (HP:0003179)1.83390897
85Abnormality of skeletal muscle fiber size (HP:0012084)1.82733938
86Broad palm (HP:0001169)1.81470061
87Asymmetry of the thorax (HP:0001555)1.81303778
88Skull defect (HP:0001362)1.81129847
89Megalocornea (HP:0000485)1.80768194
90Ankyloglossia (HP:0010296)1.80550574
91Spinal cord lesions (HP:0100561)1.80158973
92Syringomyelia (HP:0003396)1.80158973
93Hyporeflexia of lower limbs (HP:0002600)1.80142311
94Urethral obstruction (HP:0000796)1.79936677
95Increased variability in muscle fiber diameter (HP:0003557)1.78456540
96Prominent nose (HP:0000448)1.78201414
97Abnormality of the phalanges of the hallux (HP:0010057)1.75929944
98Sandal gap (HP:0001852)1.75483083
99Deep philtrum (HP:0002002)1.75316760
100Exostoses (HP:0100777)1.74931291
101Broad phalanges of the hand (HP:0009768)1.74765628
102Overlapping toe (HP:0001845)1.74237436
103Abnormality of the calcaneus (HP:0008364)1.72789654
104Metaphyseal cupping (HP:0003021)1.72518836
105Impaired smooth pursuit (HP:0007772)1.72418054
106Abnormal large intestine physiology (HP:0012700)1.72337756
107Natal tooth (HP:0000695)1.72085008
108Coronal craniosynostosis (HP:0004440)1.72013626
109Abnormality of the left ventricular outflow tract (HP:0011103)1.71675328
110Subaortic stenosis (HP:0001682)1.71675328
111Flat cornea (HP:0007720)1.71023764
112Abnormal hair whorl (HP:0010721)1.70274929
113Absent eyelashes (HP:0000561)1.70210151
114Urinary bladder sphincter dysfunction (HP:0002839)1.69877082
115Mitral valve prolapse (HP:0001634)1.69628417
116Nephroblastoma (Wilms tumor) (HP:0002667)1.68957845
117Broad finger (HP:0001500)1.68944455
118Back pain (HP:0003418)1.68904718
119Colon cancer (HP:0003003)1.68862198
120Ulnar bowing (HP:0003031)1.68338494
121Arnold-Chiari malformation (HP:0002308)1.67843599
122Midline defect of the nose (HP:0004122)1.67590915
123Vertebral arch anomaly (HP:0008438)1.67364070
124Uterine leiomyosarcoma (HP:0002891)1.67327725
125Leiomyosarcoma (HP:0100243)1.67327725
126Anal stenosis (HP:0002025)1.67045483
127Precocious puberty (HP:0000826)1.66290310
128Lymphangioma (HP:0100764)1.66151085
129Autoamputation (HP:0001218)1.66119396
130Distal upper limb amyotrophy (HP:0007149)1.65963776
131Upper limb amyotrophy (HP:0009129)1.65963776
132Choanal stenosis (HP:0000452)1.65431222
133Aneurysm (HP:0002617)1.65408054
134Ventricular tachycardia (HP:0004756)1.65094185
135Hand muscle atrophy (HP:0009130)1.64499039
136Cutaneous syndactyly (HP:0012725)1.64362577
137Transitional cell carcinoma of the bladder (HP:0006740)1.64252699
138Arterial tortuosity (HP:0005116)1.64032309
139Bladder diverticulum (HP:0000015)1.63749439
140Deep palmar crease (HP:0006191)1.63261877
141Abnormality of ocular smooth pursuit (HP:0000617)1.63103018
142Rectal prolapse (HP:0002035)1.62967547
143Flat acetabular roof (HP:0003180)1.62755148
144Relative macrocephaly (HP:0004482)1.62720447
145Smooth philtrum (HP:0000319)1.62451626
146Bladder neoplasm (HP:0009725)1.60748171
147Bladder carcinoma (HP:0002862)1.60748171
148Lip pit (HP:0100267)1.60281209
149Oligodactyly (HP:0012165)1.59725968
150Abnormality of chromosome segregation (HP:0002916)1.59715130
151Hepatoblastoma (HP:0002884)1.59348965
152Cortical dysplasia (HP:0002539)1.59153665
153Spina bifida occulta (HP:0003298)1.58792250
154Hammertoe (HP:0001765)1.58590087
155Curly hair (HP:0002212)1.58157595
156Generalized hypotonia (HP:0001290)1.57166405
157Abnormality of pain sensation (HP:0010832)1.57059754
158Impaired pain sensation (HP:0007328)1.57059754
159Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.56585187
160Patellar dislocation (HP:0002999)1.56236204
161Decreased motor nerve conduction velocity (HP:0003431)1.56230179
162Exercise-induced myalgia (HP:0003738)1.56103680
163Cubitus valgus (HP:0002967)1.55876280
164Broad long bones (HP:0005622)1.55340366
165Obstructive sleep apnea (HP:0002870)1.55299149
166Broad metatarsal (HP:0001783)1.54867789
167Embryonal renal neoplasm (HP:0011794)1.54856413
168Renal cell carcinoma (HP:0005584)1.54519725
169Rhabdomyosarcoma (HP:0002859)1.54207073
170Abnormality of the aortic arch (HP:0012303)1.52731499
171Broad phalanx (HP:0006009)1.52595529

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.45614418
2LATS23.47891038
3LATS13.39818305
4CDC72.68050323
5EEF2K2.58349037
6MAP3K92.50470427
7TRIB32.43865064
8SMG12.27035354
9STK32.21483082
10TTN2.16340186
11MAP3K102.15685200
12PKN22.15553738
13KSR21.84528896
14RIPK11.76387693
15NEK21.75489530
16MAP3K41.74654366
17CAMK1G1.72566349
18BRSK21.70165972
19CAMK1D1.69545934
20NEK11.69272287
21PRKD31.65415842
22AKT31.61388677
23BRD41.58456624
24ICK1.54544100
25MTOR1.54227131
26PDGFRA1.51618735
27PAK61.49919541
28TAOK11.43666423
29ALK1.42482988
30SGK21.30826865
31PTK61.28389329
32FGFR41.26109691
33TTK1.26098357
34KSR11.25353840
35TYRO31.23440608
36PRPF4B1.22693175
37DMPK1.18472432
38NTRK31.16934637
39MAP3K131.15131715
40SGK4941.14210707
41SGK2231.14210707
42STK381.13761084
43RET1.13745582
44TAF11.12893929
45MARK11.10416863
46STK38L1.05622258
47EIF2AK11.03518687
48SCYL21.01696873
49CDK41.00109335
50MINK10.98574067
51TSSK60.98478554
52PNCK0.97478579
53NTRK20.96635386
54STK100.94149347
55MKNK10.93932244
56CHEK10.91898567
57NTRK10.91376058
58FGFR10.90587868
59OBSCN0.90182216
60PTK20.89110873
61RPS6KB20.88817371
62CDK60.88498368
63SRPK10.87406863
64CDK90.87328242
65SIK20.86484152
66MAP3K20.84466662
67DYRK30.83799446
68PDGFRB0.83114382
69PASK0.79751668
70WEE10.78651905
71MAP3K80.78419708
72* CDK20.77250971
73MELK0.75310831
74CAMK40.73548865
75CSNK1E0.73072888
76CHEK20.72805236
77STK240.70495346
78ATM0.68847563
79MAPK100.66961223
80STK110.64633982
81MAP2K40.63324630
82PLK20.63169541
83MAP3K60.63085617
84PAK30.62494574
85MARK20.61961386
86PRKAA10.61411635
87PLK30.61308762
88PAK20.60999616
89NEK90.60908882
90SGK30.59097785
91CDK10.58816820
92CLK10.58746676
93SIK10.58056406
94FGFR20.57730140
95RAF10.57588943
96RPS6KA20.57410035
97MAPK140.56846575
98PBK0.55873085
99CSNK1D0.55631601
100MET0.54881311
101PLK10.54799884
102CDK70.54640649
103GSK3B0.54170457
104CSNK1G20.53969534
105CDC42BPA0.53397587
106FGFR30.53180263
107MAP3K70.52278766
108RPS6KB10.52004601
109EPHB20.51708154
110PRKAA20.51367352
111ATR0.50895365
112TNIK0.50588108
113WNK10.50547656
114STK40.49281728
115UHMK10.49039185
116CDK140.47297018
117BRAF0.47201427
118CAMK10.47161340
119ERBB20.46238199
120BMX0.46193312
121RPS6KC10.44003914
122RPS6KL10.44003914
123DDR20.43227114
124CDK150.42883265
125PRKDC0.42562499
126AKT20.42558515
127CAMKK10.42246088
128PAK40.42177851
129EPHB10.41886795
130BRSK10.41298394
131DYRK1B0.40773748
132RPS6KA10.40367635
133MKNK20.40156524
134HIPK20.39756183
135MAPK10.39695658
136RPS6KA30.39307993
137PRKD20.38258505

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.48087517
2Dorso-ventral axis formation_Homo sapiens_hsa043201.94322058
3mTOR signaling pathway_Homo sapiens_hsa041501.88138200
4Lysine degradation_Homo sapiens_hsa003101.77421681
5Endometrial cancer_Homo sapiens_hsa052131.71366787
6Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.71073037
7Cell cycle_Homo sapiens_hsa041101.70985311
8Oocyte meiosis_Homo sapiens_hsa041141.70731101
9Hippo signaling pathway_Homo sapiens_hsa043901.67124052
10Colorectal cancer_Homo sapiens_hsa052101.62864020
11mRNA surveillance pathway_Homo sapiens_hsa030151.62356284
12Glioma_Homo sapiens_hsa052141.61291779
13Thyroid hormone signaling pathway_Homo sapiens_hsa049191.61251163
14Type II diabetes mellitus_Homo sapiens_hsa049301.53192195
15Basal cell carcinoma_Homo sapiens_hsa052171.52569487
16Chronic myeloid leukemia_Homo sapiens_hsa052201.51224396
17MicroRNAs in cancer_Homo sapiens_hsa052061.48741359
18Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.46473159
19Adherens junction_Homo sapiens_hsa045201.46388142
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46356241
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43217126
22RNA transport_Homo sapiens_hsa030131.43114412
23Long-term potentiation_Homo sapiens_hsa047201.42798057
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.39755670
25Estrogen signaling pathway_Homo sapiens_hsa049151.39717400
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37100304
27Renal cell carcinoma_Homo sapiens_hsa052111.35120421
28Hedgehog signaling pathway_Homo sapiens_hsa043401.34669028
29Non-small cell lung cancer_Homo sapiens_hsa052231.34103973
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.24380282
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24377814
32ErbB signaling pathway_Homo sapiens_hsa040121.24064045
33Biosynthesis of amino acids_Homo sapiens_hsa012301.22886769
34* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22208858
35Wnt signaling pathway_Homo sapiens_hsa043101.21761770
36Thyroid cancer_Homo sapiens_hsa052161.17150459
37Melanogenesis_Homo sapiens_hsa049161.16758076
38Dopaminergic synapse_Homo sapiens_hsa047281.16667160
39GnRH signaling pathway_Homo sapiens_hsa049121.15435162
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.14921690
41Gap junction_Homo sapiens_hsa045401.14376778
42Notch signaling pathway_Homo sapiens_hsa043301.14364054
43Proteoglycans in cancer_Homo sapiens_hsa052051.11754377
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11573714
45Longevity regulating pathway - mammal_Homo sapiens_hsa042111.10975997
46Nitrogen metabolism_Homo sapiens_hsa009101.10478648
47Pancreatic cancer_Homo sapiens_hsa052121.09487928
48Inositol phosphate metabolism_Homo sapiens_hsa005621.06757315
49Insulin secretion_Homo sapiens_hsa049111.05409349
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05147817
51Insulin signaling pathway_Homo sapiens_hsa049101.04909168
52Bladder cancer_Homo sapiens_hsa052191.03631622
53TGF-beta signaling pathway_Homo sapiens_hsa043501.02455421
54Glucagon signaling pathway_Homo sapiens_hsa049221.01325525
55VEGF signaling pathway_Homo sapiens_hsa043700.98275503
56Amphetamine addiction_Homo sapiens_hsa050310.98074799
57Carbon metabolism_Homo sapiens_hsa012000.96054845
58ECM-receptor interaction_Homo sapiens_hsa045120.95333268
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94554023
60Cholinergic synapse_Homo sapiens_hsa047250.94537021
61Non-homologous end-joining_Homo sapiens_hsa034500.94470371
62Choline metabolism in cancer_Homo sapiens_hsa052310.94100394
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93878807
64Cocaine addiction_Homo sapiens_hsa050300.93838618
65AMPK signaling pathway_Homo sapiens_hsa041520.93479812
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92962664
67Circadian entrainment_Homo sapiens_hsa047130.91802019
68Long-term depression_Homo sapiens_hsa047300.91126155
69Prostate cancer_Homo sapiens_hsa052150.90402124
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.87941855
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87868711
72Prolactin signaling pathway_Homo sapiens_hsa049170.86488772
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85753528
74One carbon pool by folate_Homo sapiens_hsa006700.85076488
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84977699
76DNA replication_Homo sapiens_hsa030300.83229192
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82882440
78Oxytocin signaling pathway_Homo sapiens_hsa049210.82319623
79FoxO signaling pathway_Homo sapiens_hsa040680.82264994
80Axon guidance_Homo sapiens_hsa043600.81604968
81Arginine biosynthesis_Homo sapiens_hsa002200.79422100
82Tight junction_Homo sapiens_hsa045300.78801462
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78674746
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77920351
85Small cell lung cancer_Homo sapiens_hsa052220.77886355
86Insulin resistance_Homo sapiens_hsa049310.77551144
87MAPK signaling pathway_Homo sapiens_hsa040100.76953413
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76712189
89* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76454289
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76365405
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74137230
92Pathways in cancer_Homo sapiens_hsa052000.74065319
93Synaptic vesicle cycle_Homo sapiens_hsa047210.73747392
94Glutamatergic synapse_Homo sapiens_hsa047240.73003777
95Focal adhesion_Homo sapiens_hsa045100.72635148
96Pentose phosphate pathway_Homo sapiens_hsa000300.72607022
97Rap1 signaling pathway_Homo sapiens_hsa040150.72534046
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72451091
99Renin secretion_Homo sapiens_hsa049240.71819302
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69749247
101HTLV-I infection_Homo sapiens_hsa051660.68485683
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68088038
103Spliceosome_Homo sapiens_hsa030400.67493045
104Olfactory transduction_Homo sapiens_hsa047400.67251135
105Gastric acid secretion_Homo sapiens_hsa049710.67044990
106Viral carcinogenesis_Homo sapiens_hsa052030.66901430
107Melanoma_Homo sapiens_hsa052180.66065407
108Acute myeloid leukemia_Homo sapiens_hsa052210.65517556
109Steroid biosynthesis_Homo sapiens_hsa001000.65213223
110Nicotine addiction_Homo sapiens_hsa050330.65018355
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65004045
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63657488
113cAMP signaling pathway_Homo sapiens_hsa040240.62645842
114Dilated cardiomyopathy_Homo sapiens_hsa054140.62439841
115HIF-1 signaling pathway_Homo sapiens_hsa040660.61427372
116Fatty acid biosynthesis_Homo sapiens_hsa000610.61347490
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61184381
118Thyroid hormone synthesis_Homo sapiens_hsa049180.60211045
119Salivary secretion_Homo sapiens_hsa049700.59936244
120p53 signaling pathway_Homo sapiens_hsa041150.59097382
121Circadian rhythm_Homo sapiens_hsa047100.58908918
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.55710704
123Amoebiasis_Homo sapiens_hsa051460.53963421
124Pyruvate metabolism_Homo sapiens_hsa006200.50549362

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