UBE3D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1replication fork processing (GO:0031297)4.68758509
2somatic hypermutation of immunoglobulin genes (GO:0016446)3.94729961
3somatic diversification of immune receptors via somatic mutation (GO:0002566)3.94729961
4establishment of protein localization to mitochondrial membrane (GO:0090151)3.81938573
5DNA double-strand break processing (GO:0000729)3.66415302
6chromatin remodeling at centromere (GO:0031055)3.62189467
7maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.57870542
8mitochondrial respiratory chain complex I assembly (GO:0032981)3.57448622
9NADH dehydrogenase complex assembly (GO:0010257)3.57448622
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.57448622
11protein complex biogenesis (GO:0070271)3.56906221
12negative regulation of DNA-dependent DNA replication (GO:2000104)3.56445896
13mitochondrial respiratory chain complex assembly (GO:0033108)3.50030748
14respiratory chain complex IV assembly (GO:0008535)3.48318623
15exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.47436139
16nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.46551382
17proteasome assembly (GO:0043248)3.41448002
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.38071392
19DNA replication checkpoint (GO:0000076)3.37819900
20negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.35676561
21negative regulation of translation, ncRNA-mediated (GO:0040033)3.35676561
22regulation of translation, ncRNA-mediated (GO:0045974)3.35676561
23CENP-A containing nucleosome assembly (GO:0034080)3.34092852
24regulation of mitotic spindle checkpoint (GO:1903504)3.25611235
25regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.25611235
26water-soluble vitamin biosynthetic process (GO:0042364)3.20905152
27DNA strand renaturation (GO:0000733)3.19614380
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.18602806
29protein-cofactor linkage (GO:0018065)3.17455579
30cytochrome complex assembly (GO:0017004)3.13286288
31peptidyl-histidine modification (GO:0018202)3.11702465
32histone exchange (GO:0043486)3.11647628
33ATP synthesis coupled proton transport (GO:0015986)3.11537129
34energy coupled proton transport, down electrochemical gradient (GO:0015985)3.11537129
35recombinational repair (GO:0000725)3.11080253
36double-strand break repair via homologous recombination (GO:0000724)3.09589416
37nonmotile primary cilium assembly (GO:0035058)3.08586202
38DNA damage response, detection of DNA damage (GO:0042769)3.02624008
39DNA deamination (GO:0045006)2.98616823
40protein K6-linked ubiquitination (GO:0085020)2.96468700
41kidney morphogenesis (GO:0060993)2.96035521
42epithelial cilium movement (GO:0003351)2.95218224
43maturation of 5.8S rRNA (GO:0000460)2.95039571
44regulation of nuclear cell cycle DNA replication (GO:0033262)2.94524287
45chaperone-mediated protein transport (GO:0072321)2.93008955
46neural tube formation (GO:0001841)2.92661783
47resolution of meiotic recombination intermediates (GO:0000712)2.91271019
48reciprocal DNA recombination (GO:0035825)2.88626093
49reciprocal meiotic recombination (GO:0007131)2.88626093
50epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.80652549
51pseudouridine synthesis (GO:0001522)2.79532179
52termination of RNA polymerase III transcription (GO:0006386)2.76315942
53transcription elongation from RNA polymerase III promoter (GO:0006385)2.76315942
54synapsis (GO:0007129)2.75803820
55intraciliary transport (GO:0042073)2.73273579
56rRNA modification (GO:0000154)2.71575859
57tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.70584235
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.70584235
59kinetochore assembly (GO:0051382)2.69417929
60RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.68970884
61ubiquinone biosynthetic process (GO:0006744)2.68556750
62ubiquinone metabolic process (GO:0006743)2.66514248
63behavioral response to nicotine (GO:0035095)2.64198854
64regulation of DNA endoreduplication (GO:0032875)2.60620850
65electron transport chain (GO:0022900)2.59881893
66respiratory electron transport chain (GO:0022904)2.58990529
67maturation of SSU-rRNA (GO:0030490)2.57613696
68kinetochore organization (GO:0051383)2.56888836
69postreplication repair (GO:0006301)2.56340610
70mitochondrial RNA metabolic process (GO:0000959)2.54691832
71intracellular protein transmembrane import (GO:0044743)2.54186245
72cilium movement (GO:0003341)2.54175996
73ncRNA catabolic process (GO:0034661)2.54143729
74purine nucleobase biosynthetic process (GO:0009113)2.52684709
75regulation of meiosis I (GO:0060631)2.52295013
76protein neddylation (GO:0045116)2.51443114
77somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.50716384
78somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.50716384
79isotype switching (GO:0045190)2.50716384
80DNA catabolic process, exonucleolytic (GO:0000738)2.50684293
81regulation of mitochondrial translation (GO:0070129)2.50338305
82histone mRNA metabolic process (GO:0008334)2.49933269
83somatic diversification of immunoglobulins (GO:0016445)2.49130962
84rRNA methylation (GO:0031167)2.48155696
85nucleobase biosynthetic process (GO:0046112)2.47441068
86ribosomal small subunit assembly (GO:0000028)2.44656538
87DNA ligation (GO:0006266)2.42965694
88DNA replication-independent nucleosome assembly (GO:0006336)2.42211852
89DNA replication-independent nucleosome organization (GO:0034724)2.42211852
90translesion synthesis (GO:0019985)2.41212013
91negative regulation of telomere maintenance (GO:0032205)2.40989336
92cullin deneddylation (GO:0010388)2.40174191
93tRNA processing (GO:0008033)2.39929090
94indolalkylamine metabolic process (GO:0006586)2.39452980
95negative regulation of DNA recombination (GO:0045910)2.39308075
96cilium morphogenesis (GO:0060271)2.38541327
97detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.37817633
98DNA replication-dependent nucleosome assembly (GO:0006335)2.37408475
99DNA replication-dependent nucleosome organization (GO:0034723)2.37408475
100double-strand break repair (GO:0006302)2.34361383

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.22769038
2GABP_17652178_ChIP-ChIP_JURKAT_Human2.94287035
3ZNF274_21170338_ChIP-Seq_K562_Hela2.89095944
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.88237951
5E2F7_22180533_ChIP-Seq_HELA_Human2.86915708
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.84115596
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.79562978
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.79075568
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.66214455
10VDR_22108803_ChIP-Seq_LS180_Human2.61365202
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.58174761
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.57966737
13EWS_26573619_Chip-Seq_HEK293_Human2.51107139
14FUS_26573619_Chip-Seq_HEK293_Human2.49387232
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.41984265
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.27821434
17ELK1_19687146_ChIP-ChIP_HELA_Human2.21672577
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12269486
19IGF1R_20145208_ChIP-Seq_DFB_Human2.11650578
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03451884
21GBX2_23144817_ChIP-Seq_PC3_Human1.98019650
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.97372121
23P300_19829295_ChIP-Seq_ESCs_Human1.95507783
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91159545
25IRF1_19129219_ChIP-ChIP_H3396_Human1.87788498
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.87623794
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81732845
28TAF15_26573619_Chip-Seq_HEK293_Human1.81443409
29VDR_23849224_ChIP-Seq_CD4+_Human1.81266152
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80758443
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.80284423
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72136629
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.71873643
34MYC_18940864_ChIP-ChIP_HL60_Human1.70515658
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66580576
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64973713
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61692064
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52447910
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49613567
40FOXP3_21729870_ChIP-Seq_TREG_Human1.44547801
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41920285
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39572835
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.38728134
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38315526
45MYC_18555785_ChIP-Seq_MESCs_Mouse1.37676856
46ER_23166858_ChIP-Seq_MCF-7_Human1.32608441
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31367318
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31236200
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30659039
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.27893267
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26644662
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25467347
53FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24070113
54SOX2_16153702_ChIP-ChIP_HESCs_Human1.22878450
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22488076
56KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21683906
57GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18093679
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.17859656
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.16830088
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16615028
61SMAD4_21799915_ChIP-Seq_A2780_Human1.15464587
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14980189
63CBP_20019798_ChIP-Seq_JUKART_Human1.14516417
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14516417
65TP53_22573176_ChIP-Seq_HFKS_Human1.13733907
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.12575713
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.12388783
68NANOG_19829295_ChIP-Seq_ESCs_Human1.11859168
69SOX2_19829295_ChIP-Seq_ESCs_Human1.11859168
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09655969
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09513096
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09444922
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.08836963
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08680150
75STAT3_23295773_ChIP-Seq_U87_Human1.08466224
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.08164520
77EZH2_22144423_ChIP-Seq_EOC_Human1.07324984
78TTF2_22483619_ChIP-Seq_HELA_Human1.06952641
79BCAT_22108803_ChIP-Seq_LS180_Human1.05281954
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04155929
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03870009
82AR_25329375_ChIP-Seq_VCAP_Human1.03598736
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01464667
84E2F1_21310950_ChIP-Seq_MCF-7_Human1.01372475
85TCF4_23295773_ChIP-Seq_U87_Human1.01097551
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00456782
87RNF2_27304074_Chip-Seq_NSC_Mouse1.00208319
88TCF4_22108803_ChIP-Seq_LS180_Human0.99716632
89FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96456083
90FOXA1_25329375_ChIP-Seq_VCAP_Human0.96456083
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95524462
92CRX_20693478_ChIP-Seq_RETINA_Mouse0.94669972
93RUNX2_22187159_ChIP-Seq_PCA_Human0.93159736
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93043149
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93043149
96MYC_19030024_ChIP-ChIP_MESCs_Mouse0.92505193
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91503609
98TP63_19390658_ChIP-ChIP_HaCaT_Human0.90854531
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90597080
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90419680

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.82037060
2MP0008877_abnormal_DNA_methylation2.87551760
3MP0008058_abnormal_DNA_repair2.85008367
4MP0010094_abnormal_chromosome_stability2.81581149
5MP0002938_white_spotting2.73575240
6MP0003136_yellow_coat_color2.34816092
7MP0003693_abnormal_embryo_hatching2.25874755
8MP0002102_abnormal_ear_morphology2.25039239
9MP0008057_abnormal_DNA_replication2.15207308
10MP0003880_abnormal_central_pattern2.05154377
11MP0009697_abnormal_copulation1.97058340
12MP0001293_anophthalmia1.91220575
13MP0003195_calcinosis1.89042788
14MP0000566_synostosis1.77379797
15MP0003718_maternal_effect1.75873875
16MP0003890_abnormal_embryonic-extraembry1.75268400
17MP0004147_increased_porphyrin_level1.71281416
18MP0006072_abnormal_retinal_apoptosis1.70439190
19MP0001984_abnormal_olfaction1.68639251
20MP0001529_abnormal_vocalization1.63672948
21MP0005551_abnormal_eye_electrophysiolog1.57539111
22MP0002837_dystrophic_cardiac_calcinosis1.54099625
23MP0000372_irregular_coat_pigmentation1.54060780
24MP0004133_heterotaxia1.54016360
25MP0002736_abnormal_nociception_after1.52855071
26MP0009046_muscle_twitch1.52753367
27MP0003111_abnormal_nucleus_morphology1.52586998
28MP0010030_abnormal_orbit_morphology1.49690485
29MP0003937_abnormal_limbs/digits/tail_de1.48784731
30MP0008995_early_reproductive_senescence1.46677351
31MP0000631_abnormal_neuroendocrine_gland1.45858843
32MP0001485_abnormal_pinna_reflex1.44479108
33MP0003121_genomic_imprinting1.38101863
34MP0004957_abnormal_blastocyst_morpholog1.38044811
35MP0001968_abnormal_touch/_nociception1.36930812
36MP0005084_abnormal_gallbladder_morpholo1.35063012
37MP0002160_abnormal_reproductive_system1.34253563
38MP0008789_abnormal_olfactory_epithelium1.31049673
39MP0003567_abnormal_fetal_cardiomyocyte1.30328621
40MP0002234_abnormal_pharynx_morphology1.30220266
41MP0005253_abnormal_eye_physiology1.27878019
42MP0003786_premature_aging1.25555344
43MP0003646_muscle_fatigue1.24522226
44MP0002277_abnormal_respiratory_mucosa1.23855607
45MP0005075_abnormal_melanosome_morpholog1.22099796
46MP0003122_maternal_imprinting1.20726726
47MP0003119_abnormal_digestive_system1.19111825
48MP0004142_abnormal_muscle_tone1.17420354
49MP0003077_abnormal_cell_cycle1.17036039
50MP0001929_abnormal_gametogenesis1.16682543
51MP0002210_abnormal_sex_determination1.15907237
52MP0001286_abnormal_eye_development1.15213950
53MP0008872_abnormal_physiological_respon1.14725248
54MP0006035_abnormal_mitochondrial_morpho1.13244596
55MP0001346_abnormal_lacrimal_gland1.12609083
56MP0002233_abnormal_nose_morphology1.09593256
57MP0003787_abnormal_imprinting1.08620794
58MP0000049_abnormal_middle_ear1.08350116
59MP0005389_reproductive_system_phenotype1.05302953
60MP0002697_abnormal_eye_size1.05221213
61MP0005394_taste/olfaction_phenotype1.05126600
62MP0005499_abnormal_olfactory_system1.05126600
63MP0008932_abnormal_embryonic_tissue1.04944141
64MP0002876_abnormal_thyroid_physiology1.03379367
65MP0006276_abnormal_autonomic_nervous1.03350721
66MP0006036_abnormal_mitochondrial_physio1.02972191
67MP0000653_abnormal_sex_gland1.01898861
68MP0001986_abnormal_taste_sensitivity1.01263708
69MP0001145_abnormal_male_reproductive1.00538831
70MP0000427_abnormal_hair_cycle1.00342707
71MP0002095_abnormal_skin_pigmentation1.00033879
72MP0005377_hearing/vestibular/ear_phenot0.99843557
73MP0003878_abnormal_ear_physiology0.99843557
74MP0008875_abnormal_xenobiotic_pharmacok0.97535136
75MP0005195_abnormal_posterior_eye0.96974505
76MP0005174_abnormal_tail_pigmentation0.96604101
77MP0003938_abnormal_ear_development0.96508178
78MP0003698_abnormal_male_reproductive0.96311032
79MP0001486_abnormal_startle_reflex0.95978573
80MP0001764_abnormal_homeostasis0.95452049
81MP0002751_abnormal_autonomic_nervous0.95349925
82MP0000647_abnormal_sebaceous_gland0.92642034
83MP0009745_abnormal_behavioral_response0.92005165
84MP0000778_abnormal_nervous_system0.91615030
85MP0002272_abnormal_nervous_system0.91203931
86MP0009379_abnormal_foot_pigmentation0.91036892
87MP0000516_abnormal_urinary_system0.88552984
88MP0005367_renal/urinary_system_phenotyp0.88552984
89MP0005391_vision/eye_phenotype0.87681999
90MP0002163_abnormal_gland_morphology0.87058724
91MP0005646_abnormal_pituitary_gland0.86720542
92MP0002090_abnormal_vision0.84464634
93MP0001119_abnormal_female_reproductive0.84252721
94MP0001324_abnormal_eye_pigmentation0.83706518
95MP0002638_abnormal_pupillary_reflex0.82670300
96MP0005645_abnormal_hypothalamus_physiol0.80642820
97MP0001919_abnormal_reproductive_system0.80454492
98MP0004215_abnormal_myocardial_fiber0.79939326
99MP0008007_abnormal_cellular_replicative0.78774383
100MP0005395_other_phenotype0.78130802

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.59933846
2Pancreatic fibrosis (HP:0100732)3.59603110
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.51459558
4Chromsome breakage (HP:0040012)3.34146338
5True hermaphroditism (HP:0010459)3.26564604
6Meckel diverticulum (HP:0002245)3.24275084
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.22600102
8Abnormality of midbrain morphology (HP:0002418)3.20805501
9Molar tooth sign on MRI (HP:0002419)3.20805501
10Reticulocytopenia (HP:0001896)3.16312333
11Abnormality of the ileum (HP:0001549)3.15886244
12Abnormality of chromosome stability (HP:0003220)3.01280312
13Acute necrotizing encephalopathy (HP:0006965)2.98529153
14Nephronophthisis (HP:0000090)2.95871914
15Medial flaring of the eyebrow (HP:0010747)2.87500808
16Acute encephalopathy (HP:0006846)2.68260436
17Increased CSF lactate (HP:0002490)2.64745145
18Mitochondrial inheritance (HP:0001427)2.64102802
19Ectopic kidney (HP:0000086)2.59069006
20Progressive macrocephaly (HP:0004481)2.57411906
21Colon cancer (HP:0003003)2.55663691
22Absent thumb (HP:0009777)2.54980350
23Abnormal mitochondria in muscle tissue (HP:0008316)2.53911898
24Abnormality of the preputium (HP:0100587)2.53033627
25Duplicated collecting system (HP:0000081)2.52979899
26Abnormality of the renal medulla (HP:0100957)2.45094445
27Abnormality of the labia minora (HP:0012880)2.45054011
28Abnormality of the renal collecting system (HP:0004742)2.40560588
29Hepatocellular necrosis (HP:0001404)2.40539470
30Triphalangeal thumb (HP:0001199)2.38795759
31Sclerocornea (HP:0000647)2.37489634
32Hepatic necrosis (HP:0002605)2.37195645
33Congenital primary aphakia (HP:0007707)2.36886410
34Abnormal biliary tract physiology (HP:0012439)2.36405776
35Bile duct proliferation (HP:0001408)2.36405776
36Abnormality of the renal cortex (HP:0011035)2.34093139
37Gait imbalance (HP:0002141)2.30343974
38Chronic hepatic failure (HP:0100626)2.29956985
39Clubbing of toes (HP:0100760)2.29178925
40Intestinal atresia (HP:0011100)2.26257541
41Septo-optic dysplasia (HP:0100842)2.22563778
42Genital tract atresia (HP:0001827)2.22503149
43Anencephaly (HP:0002323)2.22364642
44Abnormality of alanine metabolism (HP:0010916)2.21932795
45Hyperalaninemia (HP:0003348)2.21932795
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21932795
47Type II lissencephaly (HP:0007260)2.21109027
48Aplasia/Hypoplasia of the tongue (HP:0010295)2.20964534
493-Methylglutaconic aciduria (HP:0003535)2.15103622
50Small intestinal stenosis (HP:0012848)2.14444776
51Duodenal stenosis (HP:0100867)2.14444776
52Cystic liver disease (HP:0006706)2.14304163
53Vaginal atresia (HP:0000148)2.13430925
54Nephrogenic diabetes insipidus (HP:0009806)2.09433159
55Tubular atrophy (HP:0000092)2.08218641
56Sloping forehead (HP:0000340)2.05428683
57Methylmalonic acidemia (HP:0002912)2.05099455
58Optic nerve hypoplasia (HP:0000609)2.02926713
59Abnormality of the duodenum (HP:0002246)2.02329612
60Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02272988
61Pendular nystagmus (HP:0012043)2.01045597
62Increased serum lactate (HP:0002151)1.98736159
63Hypothermia (HP:0002045)1.98662960
64Increased hepatocellular lipid droplets (HP:0006565)1.97918418
65Cerebral edema (HP:0002181)1.96788623
66Abolished electroretinogram (ERG) (HP:0000550)1.96655876
67Postaxial foot polydactyly (HP:0001830)1.96641511
68Congenital stationary night blindness (HP:0007642)1.96385557
69Hypoplasia of the pons (HP:0012110)1.96333525
70Congenital, generalized hypertrichosis (HP:0004540)1.95075334
71Abnormality of the pons (HP:0007361)1.94303418
72Abnormal rod and cone electroretinograms (HP:0008323)1.93423122
73Preaxial hand polydactyly (HP:0001177)1.92957666
74Hyperglycinemia (HP:0002154)1.92623427
75Astigmatism (HP:0000483)1.90766093
76Renal cortical cysts (HP:0000803)1.88755722
77Male pseudohermaphroditism (HP:0000037)1.88326274
78Abnormality of the carotid arteries (HP:0005344)1.85779811
79Volvulus (HP:0002580)1.85465910
80Abnormal number of erythroid precursors (HP:0012131)1.84289003
81Dandy-Walker malformation (HP:0001305)1.83834082
82Absent radius (HP:0003974)1.83830819
83Gastrointestinal atresia (HP:0002589)1.83329590
84Abnormal respiratory motile cilium morphology (HP:0005938)1.83324555
85Abnormal respiratory epithelium morphology (HP:0012253)1.83324555
86Birth length less than 3rd percentile (HP:0003561)1.82314348
87Aplasia/Hypoplasia of the tibia (HP:0005772)1.79848754
88Absent/shortened dynein arms (HP:0200106)1.79485593
89Dynein arm defect of respiratory motile cilia (HP:0012255)1.79485593
90Abnormal ciliary motility (HP:0012262)1.79233959
91Horseshoe kidney (HP:0000085)1.79079578
92Aganglionic megacolon (HP:0002251)1.78410778
93Cerebellar dysplasia (HP:0007033)1.78275946
94Poor coordination (HP:0002370)1.78138754
95Abnormal lung lobation (HP:0002101)1.76936951
96Pancytopenia (HP:0001876)1.75902436
97Attenuation of retinal blood vessels (HP:0007843)1.75759902
98Renal hypoplasia (HP:0000089)1.75295589
99Absent forearm bone (HP:0003953)1.74991426
100Aplasia involving forearm bones (HP:0009822)1.74991426

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.89834845
2ZAK2.99876296
3BMPR1B2.93627823
4WNK32.90707941
5INSRR2.58505465
6MKNK22.51628603
7NUAK12.42838241
8CDC72.34324874
9BUB12.14298986
10VRK21.99672701
11MAP4K21.98935127
12ACVR1B1.95580897
13TRIM281.92382395
14EPHA41.88885941
15SRPK11.87627867
16VRK11.86633906
17MKNK11.84898017
18GRK11.73009714
19TNIK1.71462965
20PLK31.69489526
21EIF2AK31.68712404
22TLK11.66997233
23ADRBK21.66836110
24MST41.63880440
25PLK41.63378818
26PNCK1.61626121
27STK161.61359086
28PASK1.51386344
29MAP3K41.50598836
30BCKDK1.49215902
31BRSK21.43933408
32WEE11.43456362
33TSSK61.39739174
34PINK11.37602714
35TGFBR11.31576500
36TTK1.31241707
37STK391.29833715
38FGFR21.19428548
39MAPK131.16213915
40PLK11.13719305
41NME11.11617868
42TIE11.09562564
43CASK1.08018095
44PDK21.06257189
45TAF11.03711595
46PLK20.99020293
47ATR0.98431346
48OXSR10.96417896
49STK30.96042000
50DYRK20.95530208
51TAOK30.93768802
52STK38L0.92485465
53WNK40.90810286
54PRKCG0.89081658
55CHEK20.87385292
56MAP2K70.86537969
57PRKCE0.85974923
58CSNK1G10.84794491
59NEK10.79203547
60ATM0.78040113
61MAP3K120.73478706
62PBK0.72475380
63ERBB30.66977570
64CAMK1G0.65001359
65CSNK1G30.61868560
66BCR0.61758115
67CSNK1G20.58526603
68AURKB0.57135956
69PAK30.53287238
70CSNK1A1L0.50690386
71CHEK10.50385737
72NLK0.48932101
73PIK3CG0.47758488
74OBSCN0.47153900
75EIF2AK20.46753299
76CDK30.46279683
77CSNK1A10.46107947
78ADRBK10.45687437
79RPS6KA50.45261202
80CCNB10.44789775
81RPS6KA40.43912749
82BRD40.42276148
83DYRK30.42111816
84CSNK2A10.41610880
85FGFR10.40475824
86TXK0.39825359
87CDK80.39578671
88FLT30.39207903
89CSNK2A20.39088320
90CSNK1E0.38257917
91CDK190.36611680
92BRSK10.34407493
93PIK3CA0.33599235
94CAMK10.33485735
95CAMK1D0.33396079
96PRKDC0.32821624
97PRKCQ0.32697396
98NEK20.32430473
99CSNK1D0.29757350
100PKN10.28914992

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.28863128
2Fanconi anemia pathway_Homo sapiens_hsa034603.02136666
3Oxidative phosphorylation_Homo sapiens_hsa001902.91529012
4RNA polymerase_Homo sapiens_hsa030202.88791478
5Protein export_Homo sapiens_hsa030602.72067709
6Non-homologous end-joining_Homo sapiens_hsa034502.63448085
7Mismatch repair_Homo sapiens_hsa034302.53977983
8Proteasome_Homo sapiens_hsa030502.49137565
9Ribosome_Homo sapiens_hsa030102.42625395
10Parkinsons disease_Homo sapiens_hsa050122.38361596
11DNA replication_Homo sapiens_hsa030302.22420993
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.17426126
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.08390311
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04647813
15Basal transcription factors_Homo sapiens_hsa030221.99823887
16Huntingtons disease_Homo sapiens_hsa050161.94645154
17RNA degradation_Homo sapiens_hsa030181.94230492
18One carbon pool by folate_Homo sapiens_hsa006701.87929331
19Propanoate metabolism_Homo sapiens_hsa006401.84707013
20Butanoate metabolism_Homo sapiens_hsa006501.84543662
21Selenocompound metabolism_Homo sapiens_hsa004501.71568130
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63598907
23RNA transport_Homo sapiens_hsa030131.56952404
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52695243
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48348396
26Alzheimers disease_Homo sapiens_hsa050101.48252834
27Phototransduction_Homo sapiens_hsa047441.45404898
28Nucleotide excision repair_Homo sapiens_hsa034201.44678963
29Spliceosome_Homo sapiens_hsa030401.38589200
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37737534
31Pyrimidine metabolism_Homo sapiens_hsa002401.35432093
32Base excision repair_Homo sapiens_hsa034101.34649183
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32120786
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.30714744
35Purine metabolism_Homo sapiens_hsa002301.27441048
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.23284520
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19077588
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17159780
39Nitrogen metabolism_Homo sapiens_hsa009101.17084715
40Linoleic acid metabolism_Homo sapiens_hsa005911.13241404
41Tryptophan metabolism_Homo sapiens_hsa003801.11462116
42Steroid biosynthesis_Homo sapiens_hsa001001.09327087
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08945899
44Cell cycle_Homo sapiens_hsa041101.06786736
45Pyruvate metabolism_Homo sapiens_hsa006201.05619050
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00774998
47Cardiac muscle contraction_Homo sapiens_hsa042600.98656707
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95871066
49Nicotine addiction_Homo sapiens_hsa050330.91164663
50Hedgehog signaling pathway_Homo sapiens_hsa043400.89708693
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89445917
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87181366
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86988032
54Peroxisome_Homo sapiens_hsa041460.85540647
55Sulfur relay system_Homo sapiens_hsa041220.84237816
56Basal cell carcinoma_Homo sapiens_hsa052170.80407022
57Metabolic pathways_Homo sapiens_hsa011000.79881628
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78812956
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77131637
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72880302
61Vitamin B6 metabolism_Homo sapiens_hsa007500.72585551
62Olfactory transduction_Homo sapiens_hsa047400.71928920
63Taste transduction_Homo sapiens_hsa047420.71918098
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.71106441
65Ether lipid metabolism_Homo sapiens_hsa005650.70893574
66Chemical carcinogenesis_Homo sapiens_hsa052040.64688216
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64634491
68Caffeine metabolism_Homo sapiens_hsa002320.62373674
69Retinol metabolism_Homo sapiens_hsa008300.61594815
70beta-Alanine metabolism_Homo sapiens_hsa004100.59158073
71Fatty acid elongation_Homo sapiens_hsa000620.58218377
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58192264
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57562377
74Glutathione metabolism_Homo sapiens_hsa004800.57498844
75Folate biosynthesis_Homo sapiens_hsa007900.57303060
76Vitamin digestion and absorption_Homo sapiens_hsa049770.55905521
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.54390568
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53302856
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52249983
80TGF-beta signaling pathway_Homo sapiens_hsa043500.50501321
81Oocyte meiosis_Homo sapiens_hsa041140.49219337
82mRNA surveillance pathway_Homo sapiens_hsa030150.48877954
83Sulfur metabolism_Homo sapiens_hsa009200.48514041
84Collecting duct acid secretion_Homo sapiens_hsa049660.48467193
85Regulation of autophagy_Homo sapiens_hsa041400.47022311
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45951340
87p53 signaling pathway_Homo sapiens_hsa041150.43804149
88Systemic lupus erythematosus_Homo sapiens_hsa053220.42395513
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41748429
90Hippo signaling pathway_Homo sapiens_hsa043900.38730220
91N-Glycan biosynthesis_Homo sapiens_hsa005100.36664674
92Fat digestion and absorption_Homo sapiens_hsa049750.36527909
93Fatty acid degradation_Homo sapiens_hsa000710.31735849
94Alcoholism_Homo sapiens_hsa050340.30475002
95Arginine and proline metabolism_Homo sapiens_hsa003300.29320516
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28943820
97Wnt signaling pathway_Homo sapiens_hsa043100.27253080
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26583113
99Glycerolipid metabolism_Homo sapiens_hsa005610.25541137
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25428424

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