UBE3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.98063258
2presynaptic membrane assembly (GO:0097105)5.91446957
3vocalization behavior (GO:0071625)5.56285514
4ionotropic glutamate receptor signaling pathway (GO:0035235)5.27999751
5presynaptic membrane organization (GO:0097090)5.23455042
6regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.20179201
7glutamate receptor signaling pathway (GO:0007215)5.00882560
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.96279774
9gamma-aminobutyric acid signaling pathway (GO:0007214)4.80381821
10protein localization to synapse (GO:0035418)4.77173985
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.63214765
12regulation of glutamate receptor signaling pathway (GO:1900449)4.59769644
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.54363740
14neuron recognition (GO:0008038)4.51153062
15postsynaptic membrane organization (GO:0001941)4.46626049
16neurotransmitter-gated ion channel clustering (GO:0072578)4.45779272
17negative regulation of synaptic transmission, GABAergic (GO:0032229)4.45663994
18neuron-neuron synaptic transmission (GO:0007270)4.43848665
19mitotic sister chromatid cohesion (GO:0007064)4.38933570
20synaptic transmission, glutamatergic (GO:0035249)4.35790088
21neuronal action potential propagation (GO:0019227)4.33911665
22startle response (GO:0001964)4.31121601
23synaptic vesicle exocytosis (GO:0016079)4.29202918
24glutamate secretion (GO:0014047)4.07791070
25G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.01903915
26positive regulation of synapse assembly (GO:0051965)4.01382552
27axonal fasciculation (GO:0007413)3.98076280
28regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.95557524
29nuclear pore complex assembly (GO:0051292)3.88484108
30regulation of synaptic vesicle exocytosis (GO:2000300)3.86578646
31response to histamine (GO:0034776)3.80168162
32regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.79813503
33regulation of excitatory postsynaptic membrane potential (GO:0060079)3.78701730
34regulation of postsynaptic membrane potential (GO:0060078)3.69710017
35transmission of nerve impulse (GO:0019226)3.68194456
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.66063993
37neurotransmitter secretion (GO:0007269)3.64671031
38regulation of synaptic transmission, glutamatergic (GO:0051966)3.61350710
39negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.57673605
40regulation of synapse assembly (GO:0051963)3.53182830
41nuclear pore organization (GO:0006999)3.52050745
42long-term synaptic potentiation (GO:0060291)3.47174329
43negative regulation of neurotransmitter transport (GO:0051589)3.45842874
44positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.44722893
45cerebellar granule cell differentiation (GO:0021707)3.42778400
46behavioral fear response (GO:0001662)3.40530528
47behavioral defense response (GO:0002209)3.40530528
48regulation of synaptic vesicle transport (GO:1902803)3.35637385
49positive regulation of synapse maturation (GO:0090129)3.33235296
50regulation of respiratory system process (GO:0044065)3.31657712
51regulation of long-term neuronal synaptic plasticity (GO:0048169)3.30659411
52righting reflex (GO:0060013)3.26877164
53serotonin receptor signaling pathway (GO:0007210)3.26776661
54cytoplasmic mRNA processing body assembly (GO:0033962)3.25683355
55locomotory exploration behavior (GO:0035641)3.25453274
56synapse assembly (GO:0007416)3.24711671
57mechanosensory behavior (GO:0007638)3.24239728
58exploration behavior (GO:0035640)3.22428383
59gamma-aminobutyric acid transport (GO:0015812)3.21482294
60positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.19895432
61membrane depolarization (GO:0051899)3.19828503
62fear response (GO:0042596)3.19674996
63neurotransmitter transport (GO:0006836)3.16977675
64long-term memory (GO:0007616)3.13908050
65detection of calcium ion (GO:0005513)3.13469217
66dendritic spine morphogenesis (GO:0060997)3.11985895
67regulation of dendritic spine morphogenesis (GO:0061001)3.11845140
68negative regulation of dendrite morphogenesis (GO:0050774)3.10517053
69negative regulation of neurotransmitter secretion (GO:0046929)3.10037795
70regulation of glutamate secretion (GO:0014048)3.09469988
71membrane depolarization during action potential (GO:0086010)3.07636752
72interkinetic nuclear migration (GO:0022027)3.05983703
73regulation of DNA endoreduplication (GO:0032875)3.05862807
74dendrite development (GO:0016358)3.05697122
75regulation of synapse maturation (GO:0090128)3.05619874
76regulation of vesicle fusion (GO:0031338)3.04171940
77regulation of synaptic transmission, GABAergic (GO:0032228)3.03977100
78pyrimidine nucleobase catabolic process (GO:0006208)3.03277298
79synaptic vesicle docking involved in exocytosis (GO:0016081)3.02274784
80positive regulation of synaptic transmission, GABAergic (GO:0032230)3.01120593
81cerebellar Purkinje cell differentiation (GO:0021702)3.01033173
82positive regulation of dendritic spine morphogenesis (GO:0061003)3.00726485
83positive regulation of membrane potential (GO:0045838)3.00083019
84synapsis (GO:0007129)2.98474898
85opioid receptor signaling pathway (GO:0038003)2.96617582
86regulation of neuronal synaptic plasticity (GO:0048168)2.96215313
87learning (GO:0007612)2.95195169
88regulation of dendritic spine development (GO:0060998)2.93662455
89synaptic transmission (GO:0007268)2.92911395
90regulation of protein kinase A signaling (GO:0010738)2.92724022
91regulation of synapse organization (GO:0050807)2.92495028
92striatum development (GO:0021756)2.92494597
93synapse organization (GO:0050808)2.89630003
94regulation of respiratory gaseous exchange (GO:0043576)2.88894403
95nucleus localization (GO:0051647)2.88466678
96negative regulation of dendrite development (GO:2000171)2.87186064
97membrane assembly (GO:0071709)2.86202832
98regulation of neurotransmitter secretion (GO:0046928)2.86075910
99urinary tract smooth muscle contraction (GO:0014848)2.85995895
100layer formation in cerebral cortex (GO:0021819)2.85690818
101regulation of neurotransmitter levels (GO:0001505)2.84558728
102auditory behavior (GO:0031223)2.84492819
103cochlea development (GO:0090102)2.84238474
104sister chromatid cohesion (GO:0007062)2.83553688
105regulation of synaptic plasticity (GO:0048167)2.83070940
106membrane hyperpolarization (GO:0060081)2.82044746
107proline transport (GO:0015824)2.80774933
108positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.79884817
109synaptic vesicle endocytosis (GO:0048488)2.79861388
110intraspecies interaction between organisms (GO:0051703)2.79190578
111pre-miRNA processing (GO:0031054)2.70873820
112microtubule anchoring (GO:0034453)2.68399894
113pore complex assembly (GO:0046931)2.67964666
114regulation of RNA export from nucleus (GO:0046831)2.64144272
115establishment of nucleus localization (GO:0040023)2.63611257
116negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.60658019
117negative regulation of translation, ncRNA-mediated (GO:0040033)2.60658019
118regulation of translation, ncRNA-mediated (GO:0045974)2.60658019
119paraxial mesoderm development (GO:0048339)2.58935583
120central nervous system projection neuron axonogenesis (GO:0021952)2.57280141
121DNA double-strand break processing (GO:0000729)2.50109644
122centriole replication (GO:0007099)2.49723186
123regulation of pigment cell differentiation (GO:0050932)2.49226020
124establishment of protein localization to Golgi (GO:0072600)2.48255302
125regulation of sarcomere organization (GO:0060297)2.44185604
126monoubiquitinated protein deubiquitination (GO:0035520)2.43325992
127genitalia morphogenesis (GO:0035112)2.43237973
128DNA synthesis involved in DNA repair (GO:0000731)2.38955355
129regulation of centriole replication (GO:0046599)2.37257633
130nucleobase catabolic process (GO:0046113)2.36208389
131hindbrain development (GO:0030902)2.36119686
132negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.33049316
133actin-myosin filament sliding (GO:0033275)2.30534249
134muscle filament sliding (GO:0030049)2.30534249
135* protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.28921922
136sarcoplasmic reticulum calcium ion transport (GO:0070296)2.28094860
137cerebral cortex radially oriented cell migration (GO:0021799)2.26652443
138dendrite morphogenesis (GO:0048813)2.26511548
139protein targeting to Golgi (GO:0000042)2.26133490
140actin-mediated cell contraction (GO:0070252)2.25291883
141establishment of mitochondrion localization (GO:0051654)2.25068780
142central nervous system neuron axonogenesis (GO:0021955)2.23739491
143acrosome assembly (GO:0001675)2.22612518
144regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.22496029
145myofibril assembly (GO:0030239)2.22012795
146negative regulation of DNA-dependent DNA replication (GO:2000104)2.21692158
147NLS-bearing protein import into nucleus (GO:0006607)2.21162053
148regulation of protein polyubiquitination (GO:1902914)2.20090694
149positive regulation of cardiac muscle cell differentiation (GO:2000727)2.19910635
150positive regulation of mRNA processing (GO:0050685)2.19006425
151atrial cardiac muscle cell action potential (GO:0086014)2.18017380
152negative regulation of DNA recombination (GO:0045910)2.17293863
153regulation of cell communication by electrical coupling (GO:0010649)2.17031707
154cardiac myofibril assembly (GO:0055003)2.16336715
155negative regulation of DNA repair (GO:0045738)2.16305676
156regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.16143020
157response to pheromone (GO:0019236)2.14610328
158regulation of growth hormone secretion (GO:0060123)2.14602720
159retrograde transport, vesicle recycling within Golgi (GO:0000301)2.12436840
160neural tube formation (GO:0001841)2.10112186
161secondary heart field specification (GO:0003139)2.09750150
162heart field specification (GO:0003128)2.09750150
163positive regulation of developmental pigmentation (GO:0048087)2.08207826
164negative regulation of fibroblast apoptotic process (GO:2000270)2.07466963
165negative regulation of cytosolic calcium ion concentration (GO:0051481)2.07293886
166cardiac muscle hypertrophy (GO:0003300)2.07288977
167negative regulation of potassium ion transmembrane transport (GO:1901380)2.07055566
168cardiac muscle cell development (GO:0055013)2.06927243
169regulation of acyl-CoA biosynthetic process (GO:0050812)2.06760472
170nerve growth factor signaling pathway (GO:0038180)2.06717262
171cerebral cortex development (GO:0021987)2.06693166
172embryonic retina morphogenesis in camera-type eye (GO:0060059)2.05949431
173regulation of histone H3-K9 methylation (GO:0051570)2.05684359
174regulation of meiosis I (GO:0060631)2.04955296
175dorsal/ventral axis specification (GO:0009950)2.04282623
176regulation of cAMP-dependent protein kinase activity (GO:2000479)2.04064455
177regulation of relaxation of muscle (GO:1901077)2.03718603
178lipid translocation (GO:0034204)2.03012944
179phospholipid translocation (GO:0045332)2.03012944
180regulation of sister chromatid cohesion (GO:0007063)2.02378573
181cerebral cortex cell migration (GO:0021795)2.02013990

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.33048554
2GBX2_23144817_ChIP-Seq_PC3_Human4.60760783
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.59414679
4TAF15_26573619_Chip-Seq_HEK293_Human3.28427617
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68700739
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.60540725
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58019614
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.54965030
9* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52661285
10* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.42822246
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35484438
12FUS_26573619_Chip-Seq_HEK293_Human2.35103627
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.34680919
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.28645294
15P300_19829295_ChIP-Seq_ESCs_Human2.19827920
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18803836
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.17479535
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.14698427
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.14094824
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13565030
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12397399
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.10232799
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.10232799
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.06745764
25SMAD4_21799915_ChIP-Seq_A2780_Human2.04804947
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04250386
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.98304090
28REST_21632747_ChIP-Seq_MESCs_Mouse1.97126874
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.93517455
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.93467123
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89481703
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.88869341
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.87706101
34AR_21572438_ChIP-Seq_LNCaP_Human1.85421514
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.82692165
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79140773
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.78909727
38ZNF274_21170338_ChIP-Seq_K562_Hela1.78788199
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.78638513
40* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76755634
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70060730
42IGF1R_20145208_ChIP-Seq_DFB_Human1.69052696
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.68906749
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67255842
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.67000153
46* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.66115292
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.64569324
48E2F7_22180533_ChIP-Seq_HELA_Human1.63917793
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61022131
50EWS_26573619_Chip-Seq_HEK293_Human1.56594944
51RNF2_27304074_Chip-Seq_NSC_Mouse1.56188134
52AR_25329375_ChIP-Seq_VCAP_Human1.55028536
53ER_23166858_ChIP-Seq_MCF-7_Human1.54608017
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54514871
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.54112953
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.53751659
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50894910
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50587245
59VDR_22108803_ChIP-Seq_LS180_Human1.50077630
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49908881
61* STAT3_23295773_ChIP-Seq_U87_Human1.47049862
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.46907393
63RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45189050
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45104053
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43492782
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42553342
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.41774936
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.40974185
69DROSHA_22980978_ChIP-Seq_HELA_Human1.40001881
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39933906
71* SOX2_21211035_ChIP-Seq_LN229_Gbm1.39713585
72RARB_27405468_Chip-Seq_BRAIN_Mouse1.39610254
73TP53_16413492_ChIP-PET_HCT116_Human1.38035236
74TCF4_23295773_ChIP-Seq_U87_Human1.37066698
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35397001
76CBP_20019798_ChIP-Seq_JUKART_Human1.34704652
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34704652
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34114368
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33063789
80* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.32467098
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32063802
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28642970
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28631818
84RUNX2_22187159_ChIP-Seq_PCA_Human1.27638209
85E2F4_17652178_ChIP-ChIP_JURKAT_Human1.27299221
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.26824613
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26550892
88* ARNT_22903824_ChIP-Seq_MCF-7_Human1.26175602
89CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26027924
90TP53_18474530_ChIP-ChIP_U2OS_Human1.25903308
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25196138
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25114724
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.24747798
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24000125
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24000125
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23505853
97* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21958253
98JUN_21703547_ChIP-Seq_K562_Human1.21836573
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.21500862
100P53_22387025_ChIP-Seq_ESCs_Mouse1.21075435
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19551831
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19483468
103FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18503809
104CMYC_18555785_Chip-Seq_ESCs_Mouse1.17048862
105BCAT_22108803_ChIP-Seq_LS180_Human1.16527908
106IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14953097
107LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13524260
108YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13265046
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12850841
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12734286
111EP300_21415370_ChIP-Seq_HL-1_Mouse1.12463970
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.12126891
113AHR_22903824_ChIP-Seq_MCF-7_Human1.12013960
114NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11606441
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11606441
116SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11476899
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10676390
118CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10560166
119KDM2B_26808549_Chip-Seq_REH_Human1.09383090
120SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09349979
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.08643600
122PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07950389
123* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07337667
124TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06539547
125TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06509360
126EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05526459
127TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05160017
128RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05146795
129KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04754746
130SOX9_26525672_Chip-Seq_HEART_Mouse1.04452167
131MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03264401
132MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01964226
133TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01900431
134P300_18555785_Chip-Seq_ESCs_Mouse1.00016021

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.67193038
2MP0004859_abnormal_synaptic_plasticity4.34467042
3* MP0003635_abnormal_synaptic_transmissio3.53585919
4MP0009745_abnormal_behavioral_response3.41482258
5MP0008057_abnormal_DNA_replication3.38168924
6MP0009046_muscle_twitch3.08528920
7MP0001968_abnormal_touch/_nociception2.98905804
8* MP0002064_seizures2.97903629
9* MP0002063_abnormal_learning/memory/cond2.89804497
10MP0004270_analgesia2.89099608
11MP0002572_abnormal_emotion/affect_behav2.78323996
12MP0006276_abnormal_autonomic_nervous2.75124913
13MP0002736_abnormal_nociception_after2.65897652
14MP0002735_abnormal_chemical_nociception2.63678438
15* MP0002272_abnormal_nervous_system2.48507891
16MP0001486_abnormal_startle_reflex2.43734023
17MP0001188_hyperpigmentation2.40452003
18MP0002734_abnormal_mechanical_nocicepti2.33068758
19MP0003787_abnormal_imprinting2.33062627
20MP0001440_abnormal_grooming_behavior2.31629199
21* MP0001501_abnormal_sleep_pattern2.27073246
22* MP0002067_abnormal_sensory_capabilities2.19706122
23MP0005423_abnormal_somatic_nervous2.18942907
24MP0001529_abnormal_vocalization2.13923157
25MP0005386_behavior/neurological_phenoty1.98958824
26MP0004924_abnormal_behavior1.98958824
27MP0000778_abnormal_nervous_system1.98381511
28MP0003122_maternal_imprinting1.95829080
29MP0002184_abnormal_innervation1.88863280
30MP0005646_abnormal_pituitary_gland1.83239581
31MP0005187_abnormal_penis_morphology1.82810865
32MP0002733_abnormal_thermal_nociception1.78265947
33MP0006292_abnormal_olfactory_placode1.78247833
34MP0000569_abnormal_digit_pigmentation1.77597656
35MP0003937_abnormal_limbs/digits/tail_de1.76012558
36MP0002557_abnormal_social/conspecific_i1.75256894
37MP0002009_preneoplasia1.74617616
38MP0001970_abnormal_pain_threshold1.71725523
39MP0001984_abnormal_olfaction1.66480642
40MP0002837_dystrophic_cardiac_calcinosis1.64513551
41MP0004142_abnormal_muscle_tone1.63589684
42MP0002876_abnormal_thyroid_physiology1.60076411
43MP0004084_abnormal_cardiac_muscle1.58816191
44MP0002822_catalepsy1.58455464
45MP0009780_abnormal_chondrocyte_physiolo1.56468185
46MP0003567_abnormal_fetal_cardiomyocyte1.54283889
47MP0008058_abnormal_DNA_repair1.53726043
48MP0003646_muscle_fatigue1.52678503
49MP0005645_abnormal_hypothalamus_physiol1.52182463
50MP0000383_abnormal_hair_follicle1.52072964
51MP0010678_abnormal_skin_adnexa1.43486013
52MP0001299_abnormal_eye_distance/1.40673085
53MP0001905_abnormal_dopamine_level1.37491501
54MP0005171_absent_coat_pigmentation1.35346628
55MP0003385_abnormal_body_wall1.34200886
56MP0009703_decreased_birth_body1.30719840
57MP0004145_abnormal_muscle_electrophysio1.29118388
58MP0004036_abnormal_muscle_relaxation1.28702418
59MP0000427_abnormal_hair_cycle1.28116446
60MP0008569_lethality_at_weaning1.27075769
61MP0000955_abnormal_spinal_cord1.26602923
62* MP0002066_abnormal_motor_capabilities/c1.25294404
63MP0010094_abnormal_chromosome_stability1.24644106
64MP0004742_abnormal_vestibular_system1.24190392
65* MP0002882_abnormal_neuron_morphology1.23817274
66MP0002233_abnormal_nose_morphology1.20422191
67MP0010386_abnormal_urinary_bladder1.20129513
68MP0003941_abnormal_skin_development1.19191209
69MP0000749_muscle_degeneration1.17234272
70MP0003861_abnormal_nervous_system1.16895244
71MP0004811_abnormal_neuron_physiology1.15657853
72MP0000631_abnormal_neuroendocrine_gland1.15584356
73MP0003879_abnormal_hair_cell1.14654447
74MP0002084_abnormal_developmental_patter1.13528608
75MP0003935_abnormal_craniofacial_develop1.13267869
76MP0000647_abnormal_sebaceous_gland1.11866110
77MP0005551_abnormal_eye_electrophysiolog1.11492015
78MP0005409_darkened_coat_color1.11155607
79MP0000751_myopathy1.06551842
80MP0002106_abnormal_muscle_physiology1.06479173
81MP0001502_abnormal_circadian_rhythm1.05388417
82MP0003119_abnormal_digestive_system1.04972439
83MP0004510_myositis1.04682312
84MP0004197_abnormal_fetal_growth/weight/1.02246432
85MP0003755_abnormal_palate_morphology1.01919720
86MP0001963_abnormal_hearing_physiology1.00632337
87MP0002160_abnormal_reproductive_system1.00178310
88MP0004085_abnormal_heartbeat1.00010924
89MP0009672_abnormal_birth_weight0.96922122
90* MP0002152_abnormal_brain_morphology0.96742061
91MP0000428_abnormal_craniofacial_morphol0.96448029
92MP0004215_abnormal_myocardial_fiber0.96243110
93MP0004484_altered_response_of0.94177585
94MP0010352_gastrointestinal_tract_polyps0.93986027
95MP0002269_muscular_atrophy0.93969275
96MP0008877_abnormal_DNA_methylation0.93610800
97MP0003221_abnormal_cardiomyocyte_apopto0.93033667
98MP0002909_abnormal_adrenal_gland0.92343993
99MP0005369_muscle_phenotype0.90557298
100MP0008995_early_reproductive_senescence0.90532201
101MP0001177_atelectasis0.90395713
102MP0003633_abnormal_nervous_system0.90366363
103MP0004087_abnormal_muscle_fiber0.90213854
104MP0003868_abnormal_feces_composition0.89047437
105MP0004233_abnormal_muscle_weight0.88721015
106MP0001286_abnormal_eye_development0.87720933
107MP0005620_abnormal_muscle_contractility0.87370517
108MP0001485_abnormal_pinna_reflex0.86613758
109MP0009697_abnormal_copulation0.85390034
110* MP0003121_genomic_imprinting0.85207847
111MP0002752_abnormal_somatic_nervous0.85189744
112MP0004133_heterotaxia0.85069974
113MP0002081_perinatal_lethality0.84741871
114MP0010234_abnormal_vibrissa_follicle0.84704855
115MP0000537_abnormal_urethra_morphology0.84369336
116MP0002229_neurodegeneration0.83871091
117MP0000747_muscle_weakness0.83433026
118MP0000516_abnormal_urinary_system0.83415337
119MP0005367_renal/urinary_system_phenotyp0.83415337
120MP0003631_nervous_system_phenotype0.81438167
121MP0002697_abnormal_eye_size0.81011075
122MP0004957_abnormal_blastocyst_morpholog0.80517056
123MP0003329_amyloid_beta_deposits0.79967338
124MP0002234_abnormal_pharynx_morphology0.79815406
125MP0005253_abnormal_eye_physiology0.79596759
126MP0002088_abnormal_embryonic_growth/wei0.79575709
127MP0000015_abnormal_ear_pigmentation0.79466225
128MP0002085_abnormal_embryonic_tissue0.78473404
129MP0008932_abnormal_embryonic_tissue0.78359311
130MP0001879_abnormal_lymphatic_vessel0.78354386
131MP0005380_embryogenesis_phenotype0.78210731
132MP0001672_abnormal_embryogenesis/_devel0.78210731
133MP0001293_anophthalmia0.78126547
134MP0006072_abnormal_retinal_apoptosis0.77909914
135MP0000013_abnormal_adipose_tissue0.76408399
136MP0000026_abnormal_inner_ear0.75959641
137MP0002069_abnormal_eating/drinking_beha0.75655418
138MP0003137_abnormal_impulse_conducting0.75061106
139MP0003183_abnormal_peptide_metabolism0.74714848
140MP0004885_abnormal_endolymph0.74261940
141MP0003890_abnormal_embryonic-extraembry0.69975051
142MP0001664_abnormal_digestion0.69026328
143MP0008872_abnormal_physiological_respon0.67863775
144MP0001943_abnormal_respiration0.66110424
145MP0005379_endocrine/exocrine_gland_phen0.65780423
146MP0005499_abnormal_olfactory_system0.65718849
147MP0005394_taste/olfaction_phenotype0.65718849
148MP0002638_abnormal_pupillary_reflex0.64487957
149MP0005535_abnormal_body_temperature0.64434476
150MP0003632_abnormal_nervous_system0.61154286
151MP0004043_abnormal_pH_regulation0.60972207
152MP0009379_abnormal_foot_pigmentation0.59639787
153MP0003634_abnormal_glial_cell0.59141386
154MP0002751_abnormal_autonomic_nervous0.59087759
155MP0002102_abnormal_ear_morphology0.58970394
156* MP0010770_preweaning_lethality0.57416895
157* MP0002082_postnatal_lethality0.57416895
158MP0008874_decreased_physiological_sensi0.56627944

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.34892098
2Atonic seizures (HP:0010819)5.84274749
3Hyperventilation (HP:0002883)5.67799678
4Febrile seizures (HP:0002373)5.60103929
5Epileptic encephalopathy (HP:0200134)5.57320675
6Focal seizures (HP:0007359)5.36927886
7Absence seizures (HP:0002121)4.48097217
8Dialeptic seizures (HP:0011146)4.37480620
9Volvulus (HP:0002580)4.15661751
10Papillary thyroid carcinoma (HP:0002895)3.86413550
11Progressive cerebellar ataxia (HP:0002073)3.85445080
12Generalized tonic-clonic seizures (HP:0002069)3.68127477
13Gaze-evoked nystagmus (HP:0000640)3.45302201
14Myokymia (HP:0002411)3.43759054
15* Broad-based gait (HP:0002136)3.39537091
16Visual hallucinations (HP:0002367)3.34891238
17Abnormal hair whorl (HP:0010721)3.05780825
18* Drooling (HP:0002307)3.04976982
19* Excessive salivation (HP:0003781)3.04976982
20Truncal ataxia (HP:0002078)2.97714513
21* Protruding tongue (HP:0010808)2.96191072
22Amblyopia (HP:0000646)2.92011930
23Exercise-induced muscle cramps (HP:0003710)2.89950723
24Muscle fiber inclusion bodies (HP:0100299)2.79385861
25Calf muscle hypertrophy (HP:0008981)2.78185859
26Progressive inability to walk (HP:0002505)2.77120819
27Gait imbalance (HP:0002141)2.75084537
28Rimmed vacuoles (HP:0003805)2.73980333
29Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.70572113
30Epileptiform EEG discharges (HP:0011182)2.68112604
31Nemaline bodies (HP:0003798)2.63551058
32Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.53790178
33Degeneration of the lateral corticospinal tracts (HP:0002314)2.53790178
34Inability to walk (HP:0002540)2.53182449
35Dysdiadochokinesis (HP:0002075)2.51581521
36Gonadotropin excess (HP:0000837)2.51233550
37Thyroid carcinoma (HP:0002890)2.51193608
38Abnormality of the corticospinal tract (HP:0002492)2.50764352
39Impaired vibration sensation in the lower limbs (HP:0002166)2.44422800
40Poor eye contact (HP:0000817)2.43964739
41Medial flaring of the eyebrow (HP:0010747)2.43267466
42Abnormality of the left ventricular outflow tract (HP:0011103)2.43019606
43Subaortic stenosis (HP:0001682)2.43019606
44Congenital primary aphakia (HP:0007707)2.42957988
45Termporal pattern (HP:0011008)2.42016386
46Insidious onset (HP:0003587)2.42016386
47Hyperthyroidism (HP:0000836)2.39980415
48Polyphagia (HP:0002591)2.39340975
49Scanning speech (HP:0002168)2.34833387
50EEG with generalized epileptiform discharges (HP:0011198)2.32148310
51Abnormality of the labia minora (HP:0012880)2.28832602
52* Absent speech (HP:0001344)2.27190740
53Diplopia (HP:0000651)2.27160090
54Abnormality of binocular vision (HP:0011514)2.27160090
55Hepatoblastoma (HP:0002884)2.24663960
56Hemiparesis (HP:0001269)2.24048369
57Oligodactyly (hands) (HP:0001180)2.23689388
58Dysmetria (HP:0001310)2.23530676
59Abnormal eating behavior (HP:0100738)2.21999655
60Impaired social interactions (HP:0000735)2.20217859
61Abnormal social behavior (HP:0012433)2.20217859
62Impaired smooth pursuit (HP:0007772)2.19158836
63Nephrogenic diabetes insipidus (HP:0009806)2.18806715
64Fetal akinesia sequence (HP:0001989)2.17568830
65Hypothermia (HP:0002045)2.16839731
66Progressive macrocephaly (HP:0004481)2.16602315
67Hypoplastic labia majora (HP:0000059)2.14904968
68Cortical dysplasia (HP:0002539)2.14483103
69Limb dystonia (HP:0002451)2.14129843
70Gastroesophageal reflux (HP:0002020)2.11389517
71Sensory axonal neuropathy (HP:0003390)2.10802849
72* Abnormality of salivation (HP:0100755)2.10290569
73Genital tract atresia (HP:0001827)2.09849399
74Esotropia (HP:0000565)2.08370442
75Acute necrotizing encephalopathy (HP:0006965)2.06933043
76Urinary bladder sphincter dysfunction (HP:0002839)2.06540154
77Specific learning disability (HP:0001328)2.05582214
78Abnormality of the astrocytes (HP:0100707)2.05061269
79Astrocytoma (HP:0009592)2.05061269
80Abnormality of the labia majora (HP:0012881)2.04315657
81Hypsarrhythmia (HP:0002521)2.04242695
82Dynein arm defect of respiratory motile cilia (HP:0012255)2.03690457
83Absent/shortened dynein arms (HP:0200106)2.03690457
84Thickened helices (HP:0000391)2.03600564
85Type II lissencephaly (HP:0007260)2.03376922
86Vaginal atresia (HP:0000148)2.01917675
87Abnormality of the musculature of the pelvis (HP:0001469)2.01096671
88Abnormality of the hip-girdle musculature (HP:0001445)2.01096671
89Tubulointerstitial nephritis (HP:0001970)1.99823744
90Distal arthrogryposis (HP:0005684)1.99772276
91Anxiety (HP:0000739)1.99695626
92Failure to thrive in infancy (HP:0001531)1.98718298
93Rhabdomyosarcoma (HP:0002859)1.98716236
94Abnormality of the calf musculature (HP:0001430)1.98410896
95Chromsome breakage (HP:0040012)1.98297269
96Abnormality of chromosome stability (HP:0003220)1.94658758
97Aplasia/Hypoplasia of the sternum (HP:0006714)1.94046369
98Pheochromocytoma (HP:0002666)1.93273634
99Truncal obesity (HP:0001956)1.92811966
100Abnormal ciliary motility (HP:0012262)1.91297509
101Retinal dysplasia (HP:0007973)1.90169895
102Hypoventilation (HP:0002791)1.89521177
103* Blue irides (HP:0000635)1.88795904
104Glioma (HP:0009733)1.88009716
105Abnormality of midbrain morphology (HP:0002418)1.87254344
106Molar tooth sign on MRI (HP:0002419)1.87254344
107Aqueductal stenosis (HP:0002410)1.86035295
108Abnormality of ocular smooth pursuit (HP:0000617)1.85040734
109Abnormality of the renal medulla (HP:0100957)1.85010454
110Biliary tract neoplasm (HP:0100574)1.84392336
111Embryonal renal neoplasm (HP:0011794)1.84138170
112Medulloblastoma (HP:0002885)1.83932688
113Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83549365
114Status epilepticus (HP:0002133)1.83377963
115Genetic anticipation (HP:0003743)1.83328703
116Difficulty running (HP:0009046)1.82846950
117Dysmetric saccades (HP:0000641)1.82835250
118Nephroblastoma (Wilms tumor) (HP:0002667)1.81819819
119Cystic hygroma (HP:0000476)1.81417067
120Oligomenorrhea (HP:0000876)1.81053950
121Abnormality of the lower motor neuron (HP:0002366)1.80245576
122Neuroendocrine neoplasm (HP:0100634)1.79828081
123Labial hypoplasia (HP:0000066)1.79811683
124Poor coordination (HP:0002370)1.79430448
125Chromosomal breakage induced by crosslinking agents (HP:0003221)1.78628228
126Narrow nasal bridge (HP:0000446)1.78044677
127* Generalized hypopigmentation of hair (HP:0011358)1.77830861
128Abnormal mitochondria in muscle tissue (HP:0008316)1.77512388
129Intestinal atresia (HP:0011100)1.76255764
130Cerebral inclusion bodies (HP:0100314)1.75810999
131Poor suck (HP:0002033)1.75328704
132Abnormality of the ischium (HP:0003174)1.75290959
133Depression (HP:0000716)1.74919242
134Hypoplasia of the brainstem (HP:0002365)1.73473417
135Aplasia/Hypoplasia of the brainstem (HP:0007362)1.73473417
136Abnormality of the renal cortex (HP:0011035)1.73400978
137* Fair hair (HP:0002286)1.72569870
138Impaired vibratory sensation (HP:0002495)1.72232857
139Abnormality of chromosome segregation (HP:0002916)1.72092671
140Shoulder girdle muscle weakness (HP:0003547)1.71467152
141Bundle branch block (HP:0011710)1.70328331
142Renal cortical cysts (HP:0000803)1.70189404
143Muscle hypertrophy of the lower extremities (HP:0008968)1.69419568
144Urinary urgency (HP:0000012)1.68603641
145Type 1 muscle fiber predominance (HP:0003803)1.68267176
146Aplasia/Hypoplasia of the uvula (HP:0010293)1.65680472
147Neoplasm of the small intestine (HP:0100833)1.65610084
148Small hand (HP:0200055)1.65090077
149Vertebral arch anomaly (HP:0008438)1.64183174
150Nephronophthisis (HP:0000090)1.64146481
151Abnormal biliary tract morphology (HP:0012440)1.62028187
152Hypoplastic female external genitalia (HP:0012815)1.61777990
153Pelvic girdle muscle weakness (HP:0003749)1.61400144
154Lower limb muscle weakness (HP:0007340)1.60365577
155Short chin (HP:0000331)1.60015552
156Spastic gait (HP:0002064)1.58753913
157Long clavicles (HP:0000890)1.57730395
158Abnormality of the parathyroid morphology (HP:0011766)1.57602050
159Limb-girdle muscle weakness (HP:0003325)1.57129846
160Hyperkalemia (HP:0002153)1.56446125

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.04812478
2NTRK34.32865885
3EPHA43.30030905
4MAP2K73.29222195
5MAP3K43.24710171
6OBSCN2.83912884
7MAP3K122.43397782
8MARK12.29973660
9PNCK2.26037204
10TNIK2.24045764
11STK38L2.11168425
12AKT32.03522850
13PLK21.96584313
14MAP2K41.96396703
15MAPK131.95151238
16MINK11.73388280
17RIPK41.72081169
18NTRK21.67972932
19LATS11.67938901
20CAMKK21.63779210
21MAP3K91.55680025
22EIF2AK31.52501324
23PRPF4B1.49285931
24PINK11.40847057
25OXSR11.37708535
26NEK21.31709393
27CAMK2A1.29021475
28BMPR21.28325152
29CAMK2B1.28199096
30ACVR1B1.27181292
31DAPK21.26125407
32TAF11.24993311
33SGK21.23510471
34CDK191.21279021
35FRK1.21167149
36KSR11.19364119
37CDC71.18716214
38LATS21.16168988
39SRPK11.15544128
40FGR1.14186352
41SIK21.13794581
42BRSK21.11988561
43DAPK11.10583052
44CDK51.09770226
45BCR1.07056343
46PRKCG1.06911185
47GRK71.05088014
48FES1.04588548
49TTK1.04367603
50TRIM281.03415086
51GRK51.03344974
52STK31.00506419
53SGK2230.99727532
54SGK4940.99727532
55CDK30.95559566
56STK160.95543040
57MUSK0.94839726
58PAK60.94531049
59PLK40.94318677
60NEK10.94186396
61STK240.92763294
62PTK2B0.92209825
63NME10.92001974
64NLK0.91178396
65PRKCE0.90983114
66CAMK1D0.90951997
67MKNK20.87532334
68NTRK10.86547876
69MAP3K60.85668423
70STK390.84753035
71WNK30.84351700
72CCNB10.84347006
73PLK30.84223921
74FER0.83163570
75UHMK10.83049565
76DYRK30.79776929
77RPS6KA40.79581611
78CSNK1G10.79004866
79TSSK60.78665546
80WEE10.78538112
81YES10.78399586
82SGK10.78147848
83SIK30.77937497
84CSNK1G20.76557198
85ZAK0.74393094
86WNK40.73244102
87NUAK10.72841390
88ATM0.72338045
89CAMK2D0.71978140
90DMPK0.70955476
91ADRBK20.70854038
92CSNK1E0.68923567
93CSNK1A1L0.68739287
94CAMKK10.66574761
95NEK60.66161455
96STK110.65458042
97INSRR0.64878571
98DYRK1A0.63383626
99FGFR10.63159720
100TGFBR10.61929553
101ERBB30.61782712
102PIK3CA0.61754565
103FGFR20.61611623
104BRD40.60978966
105SGK30.60895040
106PKN10.57175651
107BMPR1B0.56970087
108PLK10.56269544
109ERBB40.55413114
110PAK30.53982251
111TNK20.53007911
112CAMK2G0.52685774
113CDK120.52295007
114PRKDC0.50896590
115PBK0.49900163
116CSNK1D0.49135392
117ATR0.48989067
118ADRBK10.48846832
119CAMK1G0.48310264
120CDK180.48039005
121MAP3K100.47576491
122MAPK100.47432890
123MET0.46793520
124CHEK10.46076329
125PRKACA0.44561754
126NEK90.43464016
127CDK140.43315578
128PRKG10.42725692
129CAMK40.42532419
130PHKG10.42491065
131PHKG20.42491065
132SCYL20.41622280
133TIE10.41505020
134CDK60.41254807
135CDK150.40461700
136EPHA30.40348562
137WNK10.39785671
138CAMK10.39660343
139RPS6KB10.36755431
140RPS6KA30.36433425
141CSNK1G30.34950774
142RET0.33855892
143ROCK20.33658922
144PDK40.33006257
145PDK30.33006257
146PRKCB0.32089511
147BRAF0.31700651
148MKNK10.30031933
149PRKACB0.29512681
150CDK11A0.28391552

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050335.09500485
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.22981207
3GABAergic synapse_Homo sapiens_hsa047272.83057754
4Synaptic vesicle cycle_Homo sapiens_hsa047212.79609039
5Long-term potentiation_Homo sapiens_hsa047202.76952900
6Glutamatergic synapse_Homo sapiens_hsa047242.70762896
7Morphine addiction_Homo sapiens_hsa050322.68514139
8Circadian entrainment_Homo sapiens_hsa047132.61841556
9Taste transduction_Homo sapiens_hsa047422.52393749
10Amphetamine addiction_Homo sapiens_hsa050312.51367304
11Collecting duct acid secretion_Homo sapiens_hsa049662.36178839
12Dopaminergic synapse_Homo sapiens_hsa047282.22408916
13Non-homologous end-joining_Homo sapiens_hsa034502.20244590
14Serotonergic synapse_Homo sapiens_hsa047262.20141578
15Olfactory transduction_Homo sapiens_hsa047402.19000074
16Long-term depression_Homo sapiens_hsa047302.12135741
17Salivary secretion_Homo sapiens_hsa049701.96542347
18Renin secretion_Homo sapiens_hsa049241.92048337
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.90525846
20Calcium signaling pathway_Homo sapiens_hsa040201.74598590
21Basal transcription factors_Homo sapiens_hsa030221.74491139
22mRNA surveillance pathway_Homo sapiens_hsa030151.73162315
23Insulin secretion_Homo sapiens_hsa049111.69208844
24* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.66498042
25Propanoate metabolism_Homo sapiens_hsa006401.61760759
26Fanconi anemia pathway_Homo sapiens_hsa034601.56839146
27Oxidative phosphorylation_Homo sapiens_hsa001901.56718924
28Cholinergic synapse_Homo sapiens_hsa047251.55228099
29Cocaine addiction_Homo sapiens_hsa050301.52222679
30Oxytocin signaling pathway_Homo sapiens_hsa049211.52011572
31RNA degradation_Homo sapiens_hsa030181.47772541
32Selenocompound metabolism_Homo sapiens_hsa004501.47221432
33Gastric acid secretion_Homo sapiens_hsa049711.46141211
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43960749
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41713574
36Vibrio cholerae infection_Homo sapiens_hsa051101.36242352
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35870974
38Adherens junction_Homo sapiens_hsa045201.34936180
39Axon guidance_Homo sapiens_hsa043601.34875788
40RNA transport_Homo sapiens_hsa030131.30928779
41Cell cycle_Homo sapiens_hsa041101.27156035
42Hippo signaling pathway_Homo sapiens_hsa043901.26571295
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.25435909
44Alzheimers disease_Homo sapiens_hsa050101.24950286
45Lysine degradation_Homo sapiens_hsa003101.23960978
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23462625
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23012188
48cAMP signaling pathway_Homo sapiens_hsa040241.22554991
49Phototransduction_Homo sapiens_hsa047441.15786490
50Steroid biosynthesis_Homo sapiens_hsa001001.15466599
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15011239
52GnRH signaling pathway_Homo sapiens_hsa049121.13090398
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12774942
54Gap junction_Homo sapiens_hsa045401.11460653
55Colorectal cancer_Homo sapiens_hsa052101.11459256
56Tight junction_Homo sapiens_hsa045301.11050555
57Basal cell carcinoma_Homo sapiens_hsa052171.09257150
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09079360
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07950101
60Cardiac muscle contraction_Homo sapiens_hsa042601.07533670
61Endometrial cancer_Homo sapiens_hsa052131.04213053
62Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04066814
63ErbB signaling pathway_Homo sapiens_hsa040121.00965460
64TGF-beta signaling pathway_Homo sapiens_hsa043500.99082809
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97471658
66Parkinsons disease_Homo sapiens_hsa050120.94886715
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94733573
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.93332260
69MicroRNAs in cancer_Homo sapiens_hsa052060.92621954
70Type II diabetes mellitus_Homo sapiens_hsa049300.90640093
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89433420
72Homologous recombination_Homo sapiens_hsa034400.87121828
73Melanogenesis_Homo sapiens_hsa049160.87117371
74Estrogen signaling pathway_Homo sapiens_hsa049150.86890487
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86022008
76Dilated cardiomyopathy_Homo sapiens_hsa054140.85124164
77Mismatch repair_Homo sapiens_hsa034300.84198263
78AMPK signaling pathway_Homo sapiens_hsa041520.80540732
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77075995
80Oocyte meiosis_Homo sapiens_hsa041140.76147183
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75860322
82Prostate cancer_Homo sapiens_hsa052150.75744372
83Huntingtons disease_Homo sapiens_hsa050160.73948046
84Nucleotide excision repair_Homo sapiens_hsa034200.73564334
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72065615
86Pancreatic secretion_Homo sapiens_hsa049720.71965512
87Type I diabetes mellitus_Homo sapiens_hsa049400.71728926
88Alcoholism_Homo sapiens_hsa050340.70434074
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69541326
90MAPK signaling pathway_Homo sapiens_hsa040100.65680755
91Glioma_Homo sapiens_hsa052140.65615857
92Protein export_Homo sapiens_hsa030600.64888945
93Thyroid cancer_Homo sapiens_hsa052160.63999640
94Dorso-ventral axis formation_Homo sapiens_hsa043200.63750478
95Rheumatoid arthritis_Homo sapiens_hsa053230.63036452
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63027927
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62681139
98FoxO signaling pathway_Homo sapiens_hsa040680.61573669
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60044484
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59834905
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59781991
102Circadian rhythm_Homo sapiens_hsa047100.59578988
103Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59097319
104Choline metabolism in cancer_Homo sapiens_hsa052310.56796689
105Glucagon signaling pathway_Homo sapiens_hsa049220.55439877
106Thyroid hormone synthesis_Homo sapiens_hsa049180.54759689
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54254630
108Ras signaling pathway_Homo sapiens_hsa040140.54218230
109Pyruvate metabolism_Homo sapiens_hsa006200.53148034
110Inositol phosphate metabolism_Homo sapiens_hsa005620.52765708
111Ovarian steroidogenesis_Homo sapiens_hsa049130.52574931
112Wnt signaling pathway_Homo sapiens_hsa043100.52418813
113African trypanosomiasis_Homo sapiens_hsa051430.47683827
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45717839
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.45418310
116Phagosome_Homo sapiens_hsa041450.40273054
117Rap1 signaling pathway_Homo sapiens_hsa040150.36430946
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36097900
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34607975
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33194725
121Melanoma_Homo sapiens_hsa052180.30067105
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29002544
123Ether lipid metabolism_Homo sapiens_hsa005650.27297915
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.25456110
125Fatty acid biosynthesis_Homo sapiens_hsa000610.24653538
126Renal cell carcinoma_Homo sapiens_hsa052110.23932024
127Butanoate metabolism_Homo sapiens_hsa006500.23673704
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21572309
129Insulin signaling pathway_Homo sapiens_hsa049100.19696781
130mTOR signaling pathway_Homo sapiens_hsa041500.17689274
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17133602
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.13488252
133Hedgehog signaling pathway_Homo sapiens_hsa043400.13122337
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12971921
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.11751366

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