UBE2Z

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme which ubiquitinates proteins which participate in signaling pathways and apoptosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)6.71720248
2daunorubicin metabolic process (GO:0044597)6.71720248
3polyketide metabolic process (GO:0030638)6.71720248
4heterochromatin organization (GO:0070828)5.68097127
5protein localization to kinetochore (GO:0034501)5.62990522
6negative regulation of epidermis development (GO:0045683)5.03958786
7muscle organ morphogenesis (GO:0048644)4.93667764
8negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.92508216
9maintenance of protein location in nucleus (GO:0051457)4.92457886
10regulation of mammary gland epithelial cell proliferation (GO:0033599)4.91567160
11pre-miRNA processing (GO:0031054)4.88736667
12histone H4-K12 acetylation (GO:0043983)4.85997088
13nuclear pore complex assembly (GO:0051292)4.74551894
14regulation of telomere maintenance via telomerase (GO:0032210)4.74170463
15regulation of gene silencing by RNA (GO:0060966)4.71920911
16regulation of posttranscriptional gene silencing (GO:0060147)4.71920911
17regulation of gene silencing by miRNA (GO:0060964)4.71920911
18histone H4-K5 acetylation (GO:0043981)4.71877436
19histone H4-K8 acetylation (GO:0043982)4.71877436
20Golgi transport vesicle coating (GO:0048200)4.60945181
21COPI coating of Golgi vesicle (GO:0048205)4.60945181
22regulation of hippo signaling (GO:0035330)4.53630362
23negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.49416575
24somite rostral/caudal axis specification (GO:0032525)4.43481457
25chromatin assembly (GO:0031497)4.39609897
26negative regulation of telomerase activity (GO:0051974)4.36006880
27nuclear pore organization (GO:0006999)4.31938418
28negative regulation of cell cycle G2/M phase transition (GO:1902750)4.31570765
29protein localization to endosome (GO:0036010)4.29824506
30aminoglycoside antibiotic metabolic process (GO:0030647)4.27841535
31maternal placenta development (GO:0001893)4.26659008
32regulation of response to osmotic stress (GO:0047484)4.25764089
33notochord development (GO:0030903)4.24270725
34mitotic sister chromatid segregation (GO:0000070)4.15008757
35intestinal epithelial cell development (GO:0060576)4.06267400
36RNA stabilization (GO:0043489)4.03292739
37mRNA stabilization (GO:0048255)4.03292739
38trophectodermal cell differentiation (GO:0001829)3.95716078
39branching involved in mammary gland duct morphogenesis (GO:0060444)3.95346754
40protein localization to chromosome, centromeric region (GO:0071459)3.95250912
41positive regulation of histone deacetylation (GO:0031065)3.93832239
42rRNA transcription (GO:0009303)3.93305704
43hormone catabolic process (GO:0042447)3.88258484
44regulation of MHC class I biosynthetic process (GO:0045343)3.84977088
45DNA replication-dependent nucleosome assembly (GO:0006335)3.83308137
46DNA replication-dependent nucleosome organization (GO:0034723)3.83308137
47NLS-bearing protein import into nucleus (GO:0006607)3.82360132
48skin morphogenesis (GO:0043589)3.80225698
49regulation of nuclear cell cycle DNA replication (GO:0033262)3.75617458
50sister chromatid segregation (GO:0000819)3.71059413
51intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.67189153
52negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.63980205
53histone H4-K16 acetylation (GO:0043984)3.62167080
54positive regulation of protein deacetylation (GO:0090312)3.61784981
55positive regulation of Cdc42 GTPase activity (GO:0043089)3.56829535
56polarized epithelial cell differentiation (GO:0030859)3.52770421
57regulation of apoptotic process involved in morphogenesis (GO:1902337)3.52529378
58barbed-end actin filament capping (GO:0051016)3.50727393
59negative regulation of epidermal cell differentiation (GO:0045605)3.48546637
60regulation of translation in response to stress (GO:0043555)3.45299791
61regulation of early endosome to late endosome transport (GO:2000641)3.42474130
62pinocytosis (GO:0006907)3.42028872
63cell adhesion mediated by integrin (GO:0033627)3.39649234
64pore complex assembly (GO:0046931)3.36051677
65cytidine deamination (GO:0009972)3.32226666
66cytidine metabolic process (GO:0046087)3.32226666
67cytidine catabolic process (GO:0006216)3.32226666
68primitive streak formation (GO:0090009)3.32199221
69hypotonic response (GO:0006971)3.31756318
70regulation of vitamin D biosynthetic process (GO:0060556)3.29117207
71cell fate commitment involved in formation of primary germ layer (GO:0060795)3.28220275
72epithelial cell differentiation involved in prostate gland development (GO:0060742)3.26888507
73intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.23191913
74stress fiber assembly (GO:0043149)3.20240335
75maintenance of protein localization in organelle (GO:0072595)3.18419824
76positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.18340173
77epoxygenase P450 pathway (GO:0019373)3.17392698
78maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.16929106
79adherens junction assembly (GO:0034333)3.14357170
80cell-substrate adherens junction assembly (GO:0007045)3.13361665
81focal adhesion assembly (GO:0048041)3.13361665
82phenol-containing compound catabolic process (GO:0019336)3.12422693
83regulation of glucose import in response to insulin stimulus (GO:2001273)3.12197233
84regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.11733791
85cell-substrate junction assembly (GO:0007044)3.09661280
86protein retention in ER lumen (GO:0006621)3.08050009
87negative regulation of cell size (GO:0045792)3.06895021
88cellular modified amino acid catabolic process (GO:0042219)3.06445770
89establishment of apical/basal cell polarity (GO:0035089)3.01554334
90nodal signaling pathway (GO:0038092)3.01502855
91mitotic chromosome condensation (GO:0007076)3.00815910
92formation of translation preinitiation complex (GO:0001731)2.97923961
93positive regulation of DNA-dependent DNA replication (GO:2000105)2.97858335
94epithelial cell-cell adhesion (GO:0090136)2.97081370
95retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.96956444
96desmosome organization (GO:0002934)2.91309371
97NIK/NF-kappaB signaling (GO:0038061)2.90684965
98positive regulation of SMAD protein import into nucleus (GO:0060391)2.90425728
99proline transport (GO:0015824)2.90332719
100intracellular estrogen receptor signaling pathway (GO:0030520)2.89960908
101dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.89366409
102DNA duplex unwinding (GO:0032508)2.87084370
103modulation by symbiont of host cellular process (GO:0044068)2.86676162
104cellular senescence (GO:0090398)2.86287962
105negative regulation of viral release from host cell (GO:1902187)2.85510431
106regulation of vitamin metabolic process (GO:0030656)2.85168029
107anterior/posterior axis specification, embryo (GO:0008595)2.85132205
108regulation of type I interferon-mediated signaling pathway (GO:0060338)2.84635251
109positive regulation of keratinocyte differentiation (GO:0045618)2.84166244
110retinoic acid receptor signaling pathway (GO:0048384)2.83883323
111cell migration involved in gastrulation (GO:0042074)2.83357937
112activation of Rac GTPase activity (GO:0032863)2.83317145
113DNA geometric change (GO:0032392)2.83251192
114negative regulation of potassium ion transmembrane transport (GO:1901380)2.83064736
115vitamin A metabolic process (GO:0006776)2.82642444
116positive regulation of extracellular matrix organization (GO:1903055)2.82214081
117hemidesmosome assembly (GO:0031581)2.78546099
118positive regulation of blood vessel endothelial cell migration (GO:0043536)2.78262077
119embryonic placenta development (GO:0001892)2.78247477
120bone trabecula formation (GO:0060346)2.78238934
121establishment of endothelial barrier (GO:0061028)2.77945424
122mannose metabolic process (GO:0006013)2.76138317
123cellular response to osmotic stress (GO:0071470)2.74277404
124apoptotic cell clearance (GO:0043277)2.73338281
125negative regulation of gene silencing (GO:0060969)2.73033660
126regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.72652147
127basement membrane organization (GO:0071711)2.71779644
128lipopolysaccharide-mediated signaling pathway (GO:0031663)2.71180152
129embryonic process involved in female pregnancy (GO:0060136)2.70660111
130regulation of NFAT protein import into nucleus (GO:0051532)2.70166524
131response to laminar fluid shear stress (GO:0034616)2.70075040
132negative regulation of erythrocyte differentiation (GO:0045647)2.68714517
133activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.68375276
134interferon-gamma secretion (GO:0072643)2.65993181
135cardiovascular system development (GO:0072358)2.65589536
136regulation of membrane protein ectodomain proteolysis (GO:0051043)2.64106372
137DNA unwinding involved in DNA replication (GO:0006268)2.63781311
138negative regulation of fatty acid transport (GO:2000192)2.63751630
139response to dietary excess (GO:0002021)2.63681704
140negative regulation of glial cell proliferation (GO:0060253)2.63312030
141positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.63299839
142vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.62719113
143DNA replication checkpoint (GO:0000076)2.61727832
144cytoskeletal anchoring at plasma membrane (GO:0007016)2.59988847
145interferon-gamma production (GO:0032609)2.59789666
146regulation of extracellular matrix disassembly (GO:0010715)2.59280530
147planar cell polarity pathway involved in neural tube closure (GO:0090179)2.59035205
148substrate-dependent cell migration (GO:0006929)2.56862926
149positive regulation of nuclease activity (GO:0032075)2.55202968
150regulation of histone H3-K27 methylation (GO:0061085)2.54962641
151cellular response to virus (GO:0098586)2.53532425
152endoplasmic reticulum unfolded protein response (GO:0030968)2.53200599
153semaphorin-plexin signaling pathway (GO:0071526)2.52872820
154positive regulation of endothelial cell apoptotic process (GO:2000353)2.51019459
155activation of MAPKKK activity (GO:0000185)2.49108672
156regulation of integrin activation (GO:0033623)2.47874802
157ER-nucleus signaling pathway (GO:0006984)2.47748858
158adhesion of symbiont to host (GO:0044406)2.46553480
159mammary gland epithelial cell proliferation (GO:0033598)2.43290764
160endocytic recycling (GO:0032456)2.42589163
161response to peptidoglycan (GO:0032494)2.41231767
162hyaluronan catabolic process (GO:0030214)2.41052841
163embryo implantation (GO:0007566)2.40044408
164vesicle coating (GO:0006901)2.38467965
165membrane protein ectodomain proteolysis (GO:0006509)2.38269388
166decidualization (GO:0046697)2.38026187
167peptidyl-proline hydroxylation (GO:0019511)2.37418707
168regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.37298365
169regulation of nuclease activity (GO:0032069)2.37218214
170glycosphingolipid catabolic process (GO:0046479)2.36876870
171response to type I interferon (GO:0034340)2.34562210
172response to vitamin D (GO:0033280)2.34515459
173proline biosynthetic process (GO:0006561)2.33681939
174cellular response to interferon-alpha (GO:0035457)2.33219283
175cellular response to type I interferon (GO:0071357)2.33090051
176type I interferon signaling pathway (GO:0060337)2.33090051
177virion attachment to host cell (GO:0019062)2.32381131
178adhesion of symbiont to host cell (GO:0044650)2.32381131
179cellular response to unfolded protein (GO:0034620)2.30938108
180COPII vesicle coating (GO:0048208)2.29903048
181negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.29765079
182protein hydroxylation (GO:0018126)2.27421000
183endothelial cell chemotaxis (GO:0035767)2.27401793
184negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.26469050
185endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.26326034
186negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.26263139
187regulation of T-helper 1 cell differentiation (GO:0045625)2.26117634
188endodermal cell differentiation (GO:0035987)2.25248148
189regulation of podosome assembly (GO:0071801)2.24410085
190regulation of viral release from host cell (GO:1902186)2.24171714
191myeloid dendritic cell differentiation (GO:0043011)2.21221509

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.16154097
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.16154097
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.16154097
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.63333476
5E2F7_22180533_ChIP-Seq_HELA_Human3.55349188
6POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.86240826
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.70371334
8NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.63999653
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.58913108
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.54110649
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.51555448
12* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.50107058
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.46964235
14SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.45554009
15SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.43197505
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.39794656
17TCF3_18692474_ChIP-Seq_MEFs_Mouse2.33835045
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.30819880
19ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.25051991
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.25020796
21HIF1A_21447827_ChIP-Seq_MCF-7_Human2.23683957
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.16130862
23TCF3_18692474_ChIP-Seq_MESCs_Mouse2.13787454
24CLOCK_20551151_ChIP-Seq_293T_Human2.12052845
25MYC_22102868_ChIP-Seq_BL_Human2.07768065
26STAT3_1855785_ChIP-Seq_MESCs_Mouse2.05933909
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.04887890
28TP63_19390658_ChIP-ChIP_HaCaT_Human2.04287724
29KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.97457879
30* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.96431469
31SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.91784414
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.90720318
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.89629272
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.87919140
35NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.86392728
36* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.86108042
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.80346512
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.78001654
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73735107
40* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.65961657
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61017825
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59924047
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57524944
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56116167
45POU5F1_16518401_ChIP-PET_MESCs_Mouse1.54819118
46* ELK3_25401928_ChIP-Seq_HUVEC_Human1.53548959
47TCF7_22412390_ChIP-Seq_EML_Mouse1.52273022
48TRIM28_21343339_ChIP-Seq_HEK293_Human1.51305213
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50792379
50NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.47810833
51RACK7_27058665_Chip-Seq_MCF-7_Human1.45308401
52* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.45096464
53EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.44109416
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43289514
55CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.41966447
56TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.40654851
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39560993
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37564661
59MYC_18555785_ChIP-Seq_MESCs_Mouse1.36745721
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36012671
61OCT4_18692474_ChIP-Seq_MEFs_Mouse1.34405199
62NANOG_18692474_ChIP-Seq_MEFs_Mouse1.33682766
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33219088
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.32466419
65VDR_24763502_ChIP-Seq_THP-1_Human1.32326967
66ATF3_27146783_Chip-Seq_COLON_Human1.31674208
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30860970
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30831482
69NANOG_18692474_ChIP-Seq_MESCs_Mouse1.30186763
70SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29396171
71NCOR1_26117541_ChIP-Seq_K562_Human1.29352986
72UBF1/2_26484160_Chip-Seq_HMECs_Human1.29348960
73ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28343257
74SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.28067156
75SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.28067156
76ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.27955176
77PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.27303833
78LXR_22292898_ChIP-Seq_THP-1_Human1.27097737
79CDX2_20551321_ChIP-Seq_CACO-2_Human1.26902802
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25361145
81TP53_22127205_ChIP-Seq_IMR90_Human1.25333571
82WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23953611
83KDM2B_26808549_Chip-Seq_DND41_Human1.21627790
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21394394
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21142979
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19468850
87FOXO3_23340844_ChIP-Seq_DLD1_Human1.19238767
88KDM2B_26808549_Chip-Seq_K562_Human1.18583096
89* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17247432
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17097770
91POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.16794854
92SOX2_18692474_ChIP-Seq_MEFs_Mouse1.16315443
93SOX2_18692474_ChIP-Seq_MESCs_Mouse1.15285778
94* MAF_26560356_Chip-Seq_TH1_Human1.14961205
95EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14837803
96NANOG_21062744_ChIP-ChIP_HESCs_Human1.13840203
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13417187
98KDM2B_26808549_Chip-Seq_JURKAT_Human1.12792912
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11477550
100NANOG_16518401_ChIP-PET_MESCs_Mouse1.11438085
101* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11284234
102ESR2_21235772_ChIP-Seq_MCF-7_Human1.10928312
103KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10593942
104SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10291626
105CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09613513
106RUNX1_22412390_ChIP-Seq_EML_Mouse1.09590124
107TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09442703
108POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08928830
109CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08287334
110* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07607728
111POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05643183
112IRF8_22096565_ChIP-ChIP_GC-B_Human1.05528330
113* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04671701
114MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03746568
115KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02770590
116SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02735027
117* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02573186
118STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02098714
119RXR_22158963_ChIP-Seq_LIVER_Mouse1.01086730
120PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00387899
121Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99030071
122ERG_21242973_ChIP-ChIP_JURKAT_Human0.99014538
123ZNF263_19887448_ChIP-Seq_K562_Human0.98601165
124MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98321561
125GATA6_25053715_ChIP-Seq_YYC3_Human0.98057594
126SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97194797
127MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97016821
128* TET1_21451524_ChIP-Seq_MESCs_Mouse0.96078107
129GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95960192
130ESR1_20079471_ChIP-ChIP_T-47D_Human0.95370057
131PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95358217
132P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94857051
133* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93974207
134TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.93255514
135TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93072788
136IRF8_27001747_Chip-Seq_BMDM_Mouse0.92723871
137DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91600203
138AR_21909140_ChIP-Seq_LNCAP_Human0.90696146
139SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89787828
140ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89377844
141CREB1_26743006_Chip-Seq_LNCaP_Human0.87952850
142CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87657711
143POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.86611284
144VDR_21846776_ChIP-Seq_THP-1_Human0.85541507
145SMC4_20622854_ChIP-Seq_HELA_Human0.85310211
146EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.85304882
147CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85182685
148ELF1_20517297_ChIP-Seq_JURKAT_Human0.84395062
149PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.82295579
150RUNX1_27514584_Chip-Seq_MCF-7_Human0.82084616
151GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.81827049

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.83347369
2MP0002254_reproductive_system_inflammat4.14109505
3MP0004264_abnormal_extraembryonic_tissu3.89148265
4MP0010352_gastrointestinal_tract_polyps3.49242969
5MP0004858_abnormal_nervous_system3.33346491
6MP0005058_abnormal_lysosome_morphology2.82309167
7MP0003011_delayed_dark_adaptation2.75699575
8MP0003890_abnormal_embryonic-extraembry2.68184150
9MP0005451_abnormal_body_composition2.62090509
10MP0004957_abnormal_blastocyst_morpholog2.50992262
11MP0003303_peritoneal_inflammation2.43345388
12MP0003283_abnormal_digestive_organ2.36981379
13MP0005257_abnormal_intraocular_pressure2.36406101
14MP0001849_ear_inflammation2.33338146
15MP0009840_abnormal_foam_cell2.27193173
16MP0003122_maternal_imprinting2.16714601
17MP0010234_abnormal_vibrissa_follicle2.12229923
18MP0003123_paternal_imprinting2.04704675
19MP0003191_abnormal_cellular_cholesterol1.96499890
20MP0005380_embryogenesis_phenotype1.92398484
21MP0001672_abnormal_embryogenesis/_devel1.92398484
22MP0005499_abnormal_olfactory_system1.90798644
23MP0005394_taste/olfaction_phenotype1.90798644
24MP0004510_myositis1.90664181
25MP0002332_abnormal_exercise_endurance1.88372582
26MP0003436_decreased_susceptibility_to1.88000763
27MP0008961_abnormal_basal_metabolism1.87075245
28MP0005623_abnormal_meninges_morphology1.86273840
29MP0002088_abnormal_embryonic_growth/wei1.86233054
30MP0003984_embryonic_growth_retardation1.83579870
31MP0003566_abnormal_cell_adhesion1.79574690
32MP0003121_genomic_imprinting1.75160568
33MP0002086_abnormal_extraembryonic_tissu1.73891530
34MP0005076_abnormal_cell_differentiation1.69618806
35MP0004947_skin_inflammation1.68706637
36MP0000350_abnormal_cell_proliferation1.64063045
37MP0002653_abnormal_ependyma_morphology1.63210738
38MP0005409_darkened_coat_color1.59559870
39MP0004197_abnormal_fetal_growth/weight/1.56528960
40MP0002084_abnormal_developmental_patter1.56321846
41MP0003941_abnormal_skin_development1.56306025
42MP0008057_abnormal_DNA_replication1.55749385
43MP0001348_abnormal_lacrimal_gland1.55589150
44MP0003279_aneurysm1.55386874
45MP0010030_abnormal_orbit_morphology1.53334672
46MP0004233_abnormal_muscle_weight1.47034706
47MP0005023_abnormal_wound_healing1.45522219
48MP0002877_abnormal_melanocyte_morpholog1.43456686
49MP0002085_abnormal_embryonic_tissue1.43345061
50MP0008260_abnormal_autophagy1.42101362
51MP0002060_abnormal_skin_morphology1.38797721
52MP0001730_embryonic_growth_arrest1.38665451
53MP0003119_abnormal_digestive_system1.38544622
54MP0001958_emphysema1.36947823
55MP0003172_abnormal_lysosome_physiology1.35455997
56MP0004272_abnormal_basement_membrane1.33162637
57MP0002092_abnormal_eye_morphology1.31433670
58MP0002998_abnormal_bone_remodeling1.30985210
59MP0006292_abnormal_olfactory_placode1.29585824
60MP0001533_abnormal_skeleton_physiology1.29295295
61MP0006082_CNS_inflammation1.27958134
62MP0000428_abnormal_craniofacial_morphol1.24379954
63MP0003075_altered_response_to1.23882193
64MP0000767_abnormal_smooth_muscle1.23330215
65MP0002932_abnormal_joint_morphology1.22931641
66MP0000678_abnormal_parathyroid_gland1.22502075
67MP0001697_abnormal_embryo_size1.21990554
68MP0002896_abnormal_bone_mineralization1.19015691
69MP0001216_abnormal_epidermal_layer1.18991718
70MP0004808_abnormal_hematopoietic_stem1.17797231
71MP0001293_anophthalmia1.17485425
72MP0003950_abnormal_plasma_membrane1.16963366
73MP0005248_abnormal_Harderian_gland1.15489073
74MP0002089_abnormal_postnatal_growth/wei1.14280603
75MP0004185_abnormal_adipocyte_glucose1.13431359
76MP0003077_abnormal_cell_cycle1.12034301
77MP0000750_abnormal_muscle_regeneration1.10831769
78MP0003091_abnormal_cell_migration1.10650575
79MP0008770_decreased_survivor_rate1.09985093
80MP0002925_abnormal_cardiovascular_devel1.09713746
81MP0002148_abnormal_hypersensitivity_rea1.07983276
82MP0005075_abnormal_melanosome_morpholog1.07768053
83MP0009278_abnormal_bone_marrow1.07576181
84MP0002080_prenatal_lethality1.07529130
85MP0000762_abnormal_tongue_morphology1.06602556
86MP0002233_abnormal_nose_morphology1.06341609
87MP0002127_abnormal_cardiovascular_syste1.04495385
88MP0010155_abnormal_intestine_physiology1.03187138
89MP0009333_abnormal_splenocyte_physiolog1.02816393
90MP0000432_abnormal_head_morphology1.01910259
91MP0006035_abnormal_mitochondrial_morpho1.01373724
92MP0002796_impaired_skin_barrier1.00607469
93MP0003329_amyloid_beta_deposits1.00419411
94MP0003453_abnormal_keratinocyte_physiol0.98147004
95MP0000604_amyloidosis0.97264480
96MP0003111_abnormal_nucleus_morphology0.96805958
97MP0003938_abnormal_ear_development0.96560113
98MP0000003_abnormal_adipose_tissue0.95635380
99MP0003935_abnormal_craniofacial_develop0.95572267
100MP0005164_abnormal_response_to0.95241775
101MP0005165_increased_susceptibility_to0.93953738
102MP0005621_abnormal_cell_physiology0.93288659
103MP0006054_spinal_hemorrhage0.91336668
104MP0000343_altered_response_to0.90829482
105MP0003448_altered_tumor_morphology0.90769465
106MP0005025_abnormal_response_to0.90610112
107MP0000733_abnormal_muscle_development0.90405573
108MP0009384_cardiac_valve_regurgitation0.90071990
109MP0005000_abnormal_immune_tolerance0.89902800
110MP0000685_abnormal_immune_system0.89809869
111MP0004133_heterotaxia0.88996621
112MP0000490_abnormal_crypts_of0.88705658
113MP0008438_abnormal_cutaneous_collagen0.88636045
114MP0005390_skeleton_phenotype0.88618104
115MP0003755_abnormal_palate_morphology0.88551874
116MP0005375_adipose_tissue_phenotype0.87602367
117MP0009785_altered_susceptibility_to0.87483782
118MP0005508_abnormal_skeleton_morphology0.87423467
119MP0002419_abnormal_innate_immunity0.87396934
120MP0001915_intracranial_hemorrhage0.86896830
121MP0001835_abnormal_antigen_presentation0.86545731
122MP0005666_abnormal_adipose_tissue0.85733854
123MP0002139_abnormal_hepatobiliary_system0.85217299
124MP0002114_abnormal_axial_skeleton0.84590129
125MP0000537_abnormal_urethra_morphology0.84035928
126MP0009703_decreased_birth_body0.83238294
127MP0005387_immune_system_phenotype0.82762044
128MP0001790_abnormal_immune_system0.82762044
129MP0001243_abnormal_dermal_layer0.81888507
130MP0000627_abnormal_mammary_gland0.81604377
131MP0002970_abnormal_white_adipose0.81073433
132MP0003300_gastrointestinal_ulcer0.79847443
133MP0010307_abnormal_tumor_latency0.79827526
134MP0001853_heart_inflammation0.77481117
135MP0005266_abnormal_metabolism0.76736546
136MP0001873_stomach_inflammation0.75970484
137MP0008004_abnormal_stomach_pH0.75818815
138MP0002269_muscular_atrophy0.75783993
139MP0009931_abnormal_skin_appearance0.75751673
140MP0005275_abnormal_skin_tensile0.75672911
141MP0001542_abnormal_bone_strength0.75074435
142MP0000858_altered_metastatic_potential0.74612326
143MP0005464_abnormal_platelet_physiology0.74609476
144MP0000313_abnormal_cell_death0.73665892
145MP0003315_abnormal_perineum_morphology0.73168654
146MP0002909_abnormal_adrenal_gland0.72972233
147MP0003795_abnormal_bone_structure0.72655265
148MP0000467_abnormal_esophagus_morphology0.72488227
149MP0002277_abnormal_respiratory_mucosa0.72483134
150MP0003183_abnormal_peptide_metabolism0.69770580
151MP0000377_abnormal_hair_follicle0.69362676
152MP0002111_abnormal_tail_morphology0.69092704
153MP0009053_abnormal_anal_canal0.68319730
154MP0000049_abnormal_middle_ear0.68311830
155MP0010630_abnormal_cardiac_muscle0.67906029
156MP0005501_abnormal_skin_physiology0.66986761
157MP0002697_abnormal_eye_size0.66918390
158MP0000534_abnormal_ureter_morphology0.66775939
159MP0000516_abnormal_urinary_system0.66765671
160MP0005367_renal/urinary_system_phenotyp0.66765671
161MP0010678_abnormal_skin_adnexa0.66701605
162MP0003942_abnormal_urinary_system0.66676935
163MP0002098_abnormal_vibrissa_morphology0.65871713
164MP0002452_abnormal_antigen_presenting0.64839503
165MP0005503_abnormal_tendon_morphology0.64470549

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.63276244
2Abnormality of the lower motor neuron (HP:0002366)4.68072670
3Multiple enchondromatosis (HP:0005701)4.61335008
4Hepatoblastoma (HP:0002884)4.46582965
5Ependymoma (HP:0002888)4.33846479
6Hypochromic microcytic anemia (HP:0004840)4.33631204
7Rib fusion (HP:0000902)3.70604767
8Fused cervical vertebrae (HP:0002949)3.37226359
9Astrocytoma (HP:0009592)3.37205618
10Abnormality of the astrocytes (HP:0100707)3.37205618
11Vertebral compression fractures (HP:0002953)3.37192801
12Neoplasm of striated muscle (HP:0009728)3.28993777
13Hand muscle atrophy (HP:0009130)3.13590421
14Rhabdomyosarcoma (HP:0002859)3.11890254
15Increased connective tissue (HP:0009025)3.09500360
16Short humerus (HP:0005792)2.99053501
17Trismus (HP:0000211)2.90838665
18Flat acetabular roof (HP:0003180)2.90593476
19Achilles tendon contracture (HP:0001771)2.90256059
20Aplasia/hypoplasia of the humerus (HP:0006507)2.85422741
21Distal upper limb amyotrophy (HP:0007149)2.83802227
22Upper limb amyotrophy (HP:0009129)2.83802227
23Abnormal cartilage morphology (HP:0002763)2.79089065
24Thin bony cortex (HP:0002753)2.76159782
25Hyperacusis (HP:0010780)2.76083090
26Testicular atrophy (HP:0000029)2.74733214
27Amyotrophic lateral sclerosis (HP:0007354)2.71078418
28Cervical subluxation (HP:0003308)2.69626060
29Renal duplication (HP:0000075)2.65568735
30Abnormality of the Achilles tendon (HP:0005109)2.65489523
31Arterial tortuosity (HP:0005116)2.63548602
32Vascular tortuosity (HP:0004948)2.59050269
33Difficulty running (HP:0009046)2.54805651
34Pseudobulbar signs (HP:0002200)2.53200523
35Abnormality of the salivary glands (HP:0010286)2.51889132
36Asymmetry of the thorax (HP:0001555)2.51329520
37Abnormality of glycolipid metabolism (HP:0010969)2.50596895
38Abnormality of liposaccharide metabolism (HP:0010968)2.50596895
39Abnormality of glycosphingolipid metabolism (HP:0004343)2.50596895
40Large earlobe (HP:0009748)2.49198070
41Shawl scrotum (HP:0000049)2.46787409
42Dysostosis multiplex (HP:0000943)2.45705559
43Osteolytic defects of the phalanges of the hand (HP:0009771)2.45502350
44Osteolytic defects of the hand bones (HP:0009699)2.45502350
45Abnormality of the musculature of the hand (HP:0001421)2.43870432
46Peritonitis (HP:0002586)2.39462352
47Fragile skin (HP:0001030)2.37480152
48Resting tremor (HP:0002322)2.37386274
49Atrophic scars (HP:0001075)2.36931300
50Ankle contracture (HP:0006466)2.36552414
51Distal lower limb muscle weakness (HP:0009053)2.34489975
52Protrusio acetabuli (HP:0003179)2.33845398
53Preauricular skin tag (HP:0000384)2.33812872
54Broad face (HP:0000283)2.33154776
55Ulnar bowing (HP:0003031)2.30275685
56Spondylolisthesis (HP:0003302)2.29404281
57Hyperparathyroidism (HP:0000843)2.28361820
58Aortic dissection (HP:0002647)2.28331848
59Adenoma sebaceum (HP:0009720)2.27796503
60Angiofibromas (HP:0010615)2.27796503
61Mildly elevated creatine phosphokinase (HP:0008180)2.26898579
62Neoplasm of the heart (HP:0100544)2.25786810
63Blue sclerae (HP:0000592)2.24111481
64Hypopigmentation of the fundus (HP:0007894)2.23529506
65Interstitial pulmonary disease (HP:0006530)2.23310157
66Glioma (HP:0009733)2.23286423
67Nephroblastoma (Wilms tumor) (HP:0002667)2.23224911
68Spinal rigidity (HP:0003306)2.23201528
69Hyperinsulinemic hypoglycemia (HP:0000825)2.23189230
70Skin tags (HP:0010609)2.21886195
71Short nail (HP:0001799)2.21053722
72Abnormality of the distal phalanx of the thumb (HP:0009617)2.19713451
73Ragged-red muscle fibers (HP:0003200)2.18608826
74Horizontal nystagmus (HP:0000666)2.16316208
75Dilatation of the ascending aorta (HP:0005111)2.15919419
76Urinary glycosaminoglycan excretion (HP:0003541)2.15564605
77Mucopolysacchariduria (HP:0008155)2.15564605
78Rectovaginal fistula (HP:0000143)2.15223416
79Rectal fistula (HP:0100590)2.15223416
80Missing ribs (HP:0000921)2.14236672
81Wormian bones (HP:0002645)2.14047637
82Fasciculations (HP:0002380)2.13954857
83Distal lower limb amyotrophy (HP:0008944)2.13583588
84Mitral valve prolapse (HP:0001634)2.11982665
85Aortic aneurysm (HP:0004942)2.11788293
86Vertebral fusion (HP:0002948)2.11499562
87Short 5th finger (HP:0009237)2.11312156
88Abnormality of carpal bone ossification (HP:0006257)2.11161171
89Embryonal renal neoplasm (HP:0011794)2.09150922
90Loss of speech (HP:0002371)2.08919519
91Neurofibrillary tangles (HP:0002185)2.08574524
92Abnormal ossification of hand bones (HP:0005921)2.07514275
93Micronodular cirrhosis (HP:0001413)2.06985142
94Deep venous thrombosis (HP:0002625)2.04537297
95Cerebral inclusion bodies (HP:0100314)2.03437900
96Generalized hypotonia (HP:0001290)2.03360609
97Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.02242438
98Syringomyelia (HP:0003396)2.01165958
99Spinal cord lesions (HP:0100561)2.01165958
100Nuclear cataract (HP:0100018)2.01158261
101Elbow flexion contracture (HP:0002987)2.00794119
102Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99278524
103Abnormality of polysaccharide metabolism (HP:0011012)1.99278524
104Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99278524
105Bladder diverticulum (HP:0000015)1.99010780
106Cerebral aneurysm (HP:0004944)1.98636612
107Genu recurvatum (HP:0002816)1.98160198
108Aneurysm (HP:0002617)1.98044193
109Vaginal fistula (HP:0004320)1.97964691
110Mitral regurgitation (HP:0001653)1.96830333
111Shallow orbits (HP:0000586)1.95820697
112Lymphangioma (HP:0100764)1.93559390
113Myocardial infarction (HP:0001658)1.93170898
114Periauricular skin pits (HP:0100277)1.92785351
115Preauricular pit (HP:0004467)1.92785351
116J-shaped sella turcica (HP:0002680)1.92393965
117Intestinal fistula (HP:0100819)1.92302678
118Abnormality of the distal phalanges of the toes (HP:0010182)1.91275352
119Malnutrition (HP:0004395)1.91015294
120Ankyloglossia (HP:0010296)1.89962352
121Premature rupture of membranes (HP:0001788)1.89948200
122Disproportionate tall stature (HP:0001519)1.89408434
123Spinal cord compression (HP:0002176)1.88411093
124Skin nodule (HP:0200036)1.88402359
125Abnormality of small intestinal villus morphology (HP:0011472)1.87925506
126Villous atrophy (HP:0011473)1.87925506
127Hypochromic anemia (HP:0001931)1.87827823
128Bone pain (HP:0002653)1.87186306
129Macroorchidism (HP:0000053)1.86945455
130Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.86891207
131Abnormality of the acetabulum (HP:0003170)1.86436955
132Malignant neoplasm of the central nervous system (HP:0100836)1.86216668
133Glossoptosis (HP:0000162)1.85282280
134Progressive muscle weakness (HP:0003323)1.84846358
135Upper motor neuron abnormality (HP:0002127)1.83586893
136Malignant gastrointestinal tract tumors (HP:0006749)1.82985349
137Gastrointestinal carcinoma (HP:0002672)1.82985349
138Natal tooth (HP:0000695)1.82817355
139Insomnia (HP:0100785)1.82510062
140Cupped ribs (HP:0000887)1.82023834
141Radial bowing (HP:0002986)1.80199907
142Coxa vara (HP:0002812)1.78947270
143Muscle fibrillation (HP:0010546)1.78869666
144Tetraplegia (HP:0002445)1.78009424
145Fibroma (HP:0010614)1.77937558
146Esophageal varix (HP:0002040)1.77693162
147Biconcave vertebral bodies (HP:0004586)1.77657464
148Partial duplication of thumb phalanx (HP:0009944)1.76577309
149Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.76334313
150Long palpebral fissure (HP:0000637)1.76180789
151Axonal loss (HP:0003447)1.76001764
152Selective tooth agenesis (HP:0001592)1.75244178
153Broad thumb (HP:0011304)1.74873613
154Abnormality of the thoracic spine (HP:0100711)1.74565507
155Atrophy/Degeneration involving motor neurons (HP:0007373)1.74440743
156Bifid tongue (HP:0010297)1.73607370
157Abnormality of oral frenula (HP:0000190)1.73145669
158Skin pits (HP:0100276)1.72958190
159Abnormality of chromosome segregation (HP:0002916)1.72797256
160Renal cell carcinoma (HP:0005584)1.72763838
161Emphysema (HP:0002097)1.72608255
162Partial duplication of the phalanx of hand (HP:0009999)1.71995112
163Advanced eruption of teeth (HP:0006288)1.71331470
164Leiomyosarcoma (HP:0100243)1.70027172
165Uterine leiomyosarcoma (HP:0002891)1.70027172
166Broad palm (HP:0001169)1.69946077
167Broad metatarsal (HP:0001783)1.69911179
168Spinal muscular atrophy (HP:0007269)1.69285508
169Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.66321888
170Obstructive sleep apnea (HP:0002870)1.65779689
171Increased cerebral lipofuscin (HP:0011813)1.65749438
172Long toe (HP:0010511)1.65495172
173Joint laxity (HP:0001388)1.63909679
174Generalized amyotrophy (HP:0003700)1.63198200
175Polygenic inheritance (HP:0010982)1.61354829
176Sparse lateral eyebrow (HP:0005338)1.61144588
177Congenital glaucoma (HP:0001087)1.59709517
178Absent frontal sinuses (HP:0002688)1.58994817
179Abnormality of macrophages (HP:0004311)1.57315516
180Abnormality of dentin (HP:0010299)1.56694951
181Stridor (HP:0010307)1.55745867
182Back pain (HP:0003418)1.55322997

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.77855279
2ERN14.39547464
3GRK53.52595207
4IRAK33.49099497
5GRK63.29269156
6PRPF4B3.04330421
7NME22.70679765
8SMG12.68664767
9TRIB32.66133722
10TYRO32.60476481
11FGFR42.27665988
12TGFBR22.11383604
13STK102.08155639
14CSF1R2.02842056
15EPHA21.92611520
16MATK1.92563177
17TTK1.92312083
18MAP3K101.78144778
19MST1R1.78046585
20PKN21.73995158
21LATS21.71155225
22TAOK21.70568767
23MOS1.64199898
24PAK41.61388826
25MAP3K141.56900637
26GRK11.56397957
27NTRK11.54313977
28PDGFRA1.51638506
29ALK1.48353853
30TESK11.46737630
31RIPK11.39454000
32EPHB11.36428887
33MAP3K91.33792285
34WNK11.33722415
35PRKG21.29198962
36SCYL21.28536597
37MAPK71.25379081
38CDC42BPA1.25223041
39DDR21.23556794
40EEF2K1.20134547
41BMX1.19487171
42CDK71.17676952
43ADRBK21.17356552
44LATS11.17277829
45TBK11.15981431
46MAP3K131.15345089
47TYK21.15145041
48FGFR31.04189430
49PTK21.03735529
50MTOR1.00734842
51TTN0.99888618
52LMTK20.98774754
53SIK30.97235477
54GRK70.95011354
55CAMK40.92856922
56NEK20.90978220
57RPS6KB20.90044762
58MAP2K40.88119670
59MAP3K30.87480505
60NEK10.85840816
61PIM20.85493487
62KSR20.84100759
63MAP3K70.82093173
64MAP3K10.80826169
65TESK20.80686365
66HIPK20.80564843
67JAK30.79477229
68NEK90.79053419
69MARK20.78887949
70JAK10.78734546
71CSK0.77885369
72PDPK10.76779163
73RPS6KA20.76274313
74ICK0.75401258
75SIK10.74498055
76CHEK20.73587576
77PTK60.72485514
78PLK10.71327266
79CHUK0.69462373
80PAK20.67990258
81MAP2K30.67247745
82TAOK10.65989432
83ZAP700.65520597
84ARAF0.65322122
85AKT20.64853585
86LRRK20.63212217
87CHEK10.62236575
88CDK40.61611681
89CDC70.60904338
90ADRBK10.60116607
91MET0.55381909
92IRAK40.55358745
93MAPK110.53987412
94TRPM70.53516995
95ERBB40.52878233
96MAP3K60.51445335
97MAP3K80.51079838
98MAP3K110.48027963
99RPS6KC10.47135570
100RPS6KL10.47135570
101PRKCI0.46485955
102ILK0.46043960
103IKBKE0.44750380
104DMPK0.43785950
105CDK60.43289131
106CDK20.42999781
107CLK10.42935701
108CAMK1D0.42723287
109STK30.42496964
110PAK60.42208644
111PAK30.42030255
112STK380.41752080
113PRKD20.41716094
114EPHB20.40967823
115LIMK10.40868345
116FGR0.40812648
117FLT30.40763047
118CDK90.40512267
119PAK10.39475289
120SGK30.39419895
121ROCK20.39418370
122PDGFRB0.39384210
123CSNK1E0.39238822
124GSK3A0.38906613
125RET0.38818020
126RIPK40.38640896
127MAPKAPK30.38243890
128IRAK20.36948950
129FER0.35537836
130ERBB20.35496857
131EGFR0.34917839
132MAP3K20.34579033
133INSR0.33027839
134MAP2K60.32010492
135DYRK1B0.27436103
136MAPK10.25292590
137IGF1R0.24907876
138AURKA0.24499398
139MAP2K20.23869043
140MAPK100.23000800
141MAPK120.22604532
142PRKCH0.22345561
143AURKB0.22117105
144PRKD30.20047569
145ATM0.19939309
146MELK0.19425082
147AKT30.18361984

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.19605329
2Vitamin B6 metabolism_Homo sapiens_hsa007503.11903542
3Other glycan degradation_Homo sapiens_hsa005112.77633245
4Fructose and mannose metabolism_Homo sapiens_hsa000512.58574797
5mTOR signaling pathway_Homo sapiens_hsa041502.41051562
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38924187
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.20926486
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.09751478
9Galactose metabolism_Homo sapiens_hsa000521.80957565
10Thyroid cancer_Homo sapiens_hsa052161.79698077
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.75756712
12Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.66221678
13Bladder cancer_Homo sapiens_hsa052191.65475086
14Central carbon metabolism in cancer_Homo sapiens_hsa052301.58613993
15Hepatitis C_Homo sapiens_hsa051601.53325480
16TNF signaling pathway_Homo sapiens_hsa046681.52891516
17Proteoglycans in cancer_Homo sapiens_hsa052051.48636097
18RNA transport_Homo sapiens_hsa030131.46788800
19Lysosome_Homo sapiens_hsa041421.43321217
20MicroRNAs in cancer_Homo sapiens_hsa052061.42949736
21Osteoclast differentiation_Homo sapiens_hsa043801.42937214
22Influenza A_Homo sapiens_hsa051641.38734119
23Hippo signaling pathway_Homo sapiens_hsa043901.38568255
24Adherens junction_Homo sapiens_hsa045201.38116319
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34782012
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.30847699
27VEGF signaling pathway_Homo sapiens_hsa043701.28398326
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23397478
29Hepatitis B_Homo sapiens_hsa051611.22635529
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22265040
31Regulation of actin cytoskeleton_Homo sapiens_hsa048101.22109390
32mRNA surveillance pathway_Homo sapiens_hsa030151.21371325
33Leishmaniasis_Homo sapiens_hsa051401.20782667
34Shigellosis_Homo sapiens_hsa051311.20081216
35Focal adhesion_Homo sapiens_hsa045101.19650050
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18927354
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.18883502
38Small cell lung cancer_Homo sapiens_hsa052221.18308517
39Non-small cell lung cancer_Homo sapiens_hsa052231.16393037
40Acute myeloid leukemia_Homo sapiens_hsa052211.12790226
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11780133
42One carbon pool by folate_Homo sapiens_hsa006701.10394180
43Chronic myeloid leukemia_Homo sapiens_hsa052201.09530533
44Salmonella infection_Homo sapiens_hsa051321.08753883
45Pertussis_Homo sapiens_hsa051331.07873120
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.06314044
47Phospholipase D signaling pathway_Homo sapiens_hsa040721.05806993
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01372202
49Measles_Homo sapiens_hsa051621.00910675
50Tight junction_Homo sapiens_hsa045301.00862449
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00852315
52ErbB signaling pathway_Homo sapiens_hsa040120.99115700
53Malaria_Homo sapiens_hsa051440.98951130
54p53 signaling pathway_Homo sapiens_hsa041150.98745815
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98373779
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.97605866
57Prostate cancer_Homo sapiens_hsa052150.97457544
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96905254
59Pancreatic cancer_Homo sapiens_hsa052120.96833442
60Basal cell carcinoma_Homo sapiens_hsa052170.96725849
61Pathways in cancer_Homo sapiens_hsa052000.96092325
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95278093
63Tuberculosis_Homo sapiens_hsa051520.95016435
64Nitrogen metabolism_Homo sapiens_hsa009100.94414046
65Arachidonic acid metabolism_Homo sapiens_hsa005900.93715319
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93024575
67Rap1 signaling pathway_Homo sapiens_hsa040150.92838524
68ECM-receptor interaction_Homo sapiens_hsa045120.92321023
69Dorso-ventral axis formation_Homo sapiens_hsa043200.91499313
70Linoleic acid metabolism_Homo sapiens_hsa005910.90823395
71Vibrio cholerae infection_Homo sapiens_hsa051100.90713705
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89945787
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.89783475
74Endometrial cancer_Homo sapiens_hsa052130.89713127
75Inositol phosphate metabolism_Homo sapiens_hsa005620.86548553
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84361397
77African trypanosomiasis_Homo sapiens_hsa051430.84182746
78Herpes simplex infection_Homo sapiens_hsa051680.83937453
79Insulin signaling pathway_Homo sapiens_hsa049100.83795932
80Apoptosis_Homo sapiens_hsa042100.83397912
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82783605
82Colorectal cancer_Homo sapiens_hsa052100.82658889
83AMPK signaling pathway_Homo sapiens_hsa041520.82451944
84Endocytosis_Homo sapiens_hsa041440.82268266
85Hedgehog signaling pathway_Homo sapiens_hsa043400.81314748
86* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79103798
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78660536
88Cell cycle_Homo sapiens_hsa041100.78290685
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77090412
90Glioma_Homo sapiens_hsa052140.75542521
91Insulin resistance_Homo sapiens_hsa049310.74665505
92Sphingolipid metabolism_Homo sapiens_hsa006000.73331178
93GnRH signaling pathway_Homo sapiens_hsa049120.73010543
94Renal cell carcinoma_Homo sapiens_hsa052110.72815528
95TGF-beta signaling pathway_Homo sapiens_hsa043500.72191484
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.72019901
97Viral myocarditis_Homo sapiens_hsa054160.71418063
98Viral carcinogenesis_Homo sapiens_hsa052030.70946317
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70126185
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69820345
101Choline metabolism in cancer_Homo sapiens_hsa052310.68811182
102Notch signaling pathway_Homo sapiens_hsa043300.68761549
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.68603370
104Amoebiasis_Homo sapiens_hsa051460.67914740
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67772633
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66552527
107Chemokine signaling pathway_Homo sapiens_hsa040620.65444419
108HTLV-I infection_Homo sapiens_hsa051660.64562908
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64491031
110Protein digestion and absorption_Homo sapiens_hsa049740.63592584
111Toxoplasmosis_Homo sapiens_hsa051450.62747907
112Biosynthesis of amino acids_Homo sapiens_hsa012300.61145774
113HIF-1 signaling pathway_Homo sapiens_hsa040660.60082213
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59829004
115Pentose phosphate pathway_Homo sapiens_hsa000300.59182092
116N-Glycan biosynthesis_Homo sapiens_hsa005100.58857826
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58695519
118Selenocompound metabolism_Homo sapiens_hsa004500.57285588
119T cell receptor signaling pathway_Homo sapiens_hsa046600.55590293
120Epstein-Barr virus infection_Homo sapiens_hsa051690.55211976
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54573133
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54207187
123Melanoma_Homo sapiens_hsa052180.53997710
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52218216
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51283751
1262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51239940
127Prolactin signaling pathway_Homo sapiens_hsa049170.51087442
128Phagosome_Homo sapiens_hsa041450.50603189
129Carbon metabolism_Homo sapiens_hsa012000.50321028
130Antigen processing and presentation_Homo sapiens_hsa046120.50169652
131Lysine degradation_Homo sapiens_hsa003100.50035369
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49768999
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49662632
134Rheumatoid arthritis_Homo sapiens_hsa053230.49569271
135Legionellosis_Homo sapiens_hsa051340.48796231
136B cell receptor signaling pathway_Homo sapiens_hsa046620.47182941
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.45721838
138Wnt signaling pathway_Homo sapiens_hsa043100.45688284
139Prion diseases_Homo sapiens_hsa050200.45453324
140Estrogen signaling pathway_Homo sapiens_hsa049150.44960085

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