UBE2V2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.50220453
2ATP synthesis coupled proton transport (GO:0015986)6.03174808
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.03174808
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.42771696
5neuron cell-cell adhesion (GO:0007158)5.18300814
6chaperone-mediated protein transport (GO:0072321)4.86176734
7protein neddylation (GO:0045116)4.76439597
8respiratory electron transport chain (GO:0022904)4.62563164
9electron transport chain (GO:0022900)4.50863808
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.49015115
11presynaptic membrane assembly (GO:0097105)4.15303138
12vocalization behavior (GO:0071625)4.10725685
13chromatin remodeling at centromere (GO:0031055)3.99494965
14protein complex biogenesis (GO:0070271)3.94131648
15CENP-A containing nucleosome assembly (GO:0034080)3.87005481
16presynaptic membrane organization (GO:0097090)3.86714547
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.83990668
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.83990668
19NADH dehydrogenase complex assembly (GO:0010257)3.83990668
20synaptic vesicle exocytosis (GO:0016079)3.82543603
21protein localization to synapse (GO:0035418)3.69081474
22cullin deneddylation (GO:0010388)3.61293774
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.58297265
24dopamine transport (GO:0015872)3.55485817
25mitochondrial respiratory chain complex assembly (GO:0033108)3.53520933
26startle response (GO:0001964)3.50396811
27neuronal action potential propagation (GO:0019227)3.49324710
28energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.46932668
29ATP hydrolysis coupled proton transport (GO:0015991)3.46932668
30neuron recognition (GO:0008038)3.42171627
31proteasome assembly (GO:0043248)3.39582319
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.38950547
33negative regulation of synaptic transmission, GABAergic (GO:0032229)3.38542751
34neuron-neuron synaptic transmission (GO:0007270)3.37725070
35histone exchange (GO:0043486)3.35567997
36gamma-aminobutyric acid signaling pathway (GO:0007214)3.35526848
37GTP biosynthetic process (GO:0006183)3.32508102
38respiratory chain complex IV assembly (GO:0008535)3.31311838
39regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.30396307
40nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.29427219
41exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.29195780
42regulation of mitotic spindle checkpoint (GO:1903504)3.28075374
43regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.28075374
44glutamate receptor signaling pathway (GO:0007215)3.25779084
45protein deneddylation (GO:0000338)3.22691020
46water-soluble vitamin biosynthetic process (GO:0042364)3.21490258
47postsynaptic membrane organization (GO:0001941)3.20732549
48hydrogen ion transmembrane transport (GO:1902600)3.20377813
49response to histamine (GO:0034776)3.18498801
50* positive regulation of synapse assembly (GO:0051965)3.16989207
51transferrin transport (GO:0033572)3.14411340
52synaptic transmission, glutamatergic (GO:0035249)3.10666034
53regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.10050021
54regulation of glutamate receptor signaling pathway (GO:1900449)3.07615244
55regulation of helicase activity (GO:0051095)3.04924766
56* DNA double-strand break processing (GO:0000729)3.04627646
57regulation of glutamate secretion (GO:0014048)3.03956353
58sequestering of actin monomers (GO:0042989)3.03643538
59dopamine biosynthetic process (GO:0042416)3.02841021
60purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.01424298
61regulation of short-term neuronal synaptic plasticity (GO:0048172)3.00212913
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.95205923
63DNA replication-independent nucleosome organization (GO:0034724)2.93754135
64DNA replication-independent nucleosome assembly (GO:0006336)2.93754135
65purine nucleoside triphosphate biosynthetic process (GO:0009145)2.93101274
66long-chain fatty acid biosynthetic process (GO:0042759)2.92674305
67positive regulation of protein homodimerization activity (GO:0090073)2.92563016
68ATP biosynthetic process (GO:0006754)2.92543212
69protein-cofactor linkage (GO:0018065)2.91421037
70anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90964895
71trivalent inorganic cation transport (GO:0072512)2.90456639
72ferric iron transport (GO:0015682)2.90456639
73positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.89738805
74negative regulation of DNA-dependent DNA replication (GO:2000104)2.88910459
75behavioral response to cocaine (GO:0048148)2.88865442
76negative regulation of ligase activity (GO:0051352)2.88312340
77negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.88312340
78regulation of synaptic vesicle exocytosis (GO:2000300)2.87985190
79proton transport (GO:0015992)2.87463102
80negative regulation of microtubule polymerization (GO:0031115)2.86805395
81DNA replication checkpoint (GO:0000076)2.86157337
82neurotransmitter uptake (GO:0001504)2.85212113
83organelle disassembly (GO:1903008)2.84854446
84transmission of nerve impulse (GO:0019226)2.84738310
85regulation of dopamine metabolic process (GO:0042053)2.84626592
86regulation of catecholamine metabolic process (GO:0042069)2.84626592
87negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.84014481
88negative regulation of neurotransmitter transport (GO:0051589)2.83385826
89protein localization to cilium (GO:0061512)2.82816650
90guanosine-containing compound biosynthetic process (GO:1901070)2.82709663
91inner mitochondrial membrane organization (GO:0007007)2.82577461
92cytochrome complex assembly (GO:0017004)2.81737507
93spliceosomal snRNP assembly (GO:0000387)2.80723324
94hydrogen transport (GO:0006818)2.80488731
95establishment of protein localization to mitochondrion (GO:0072655)2.79902331
96protein targeting to mitochondrion (GO:0006626)2.79617594
97negative regulation of DNA recombination (GO:0045910)2.79539880
98glutamate secretion (GO:0014047)2.78757230
99regulation of cellular amino acid metabolic process (GO:0006521)2.78500188
100UTP biosynthetic process (GO:0006228)2.73121053
101transcription elongation from RNA polymerase III promoter (GO:0006385)2.72677461
102termination of RNA polymerase III transcription (GO:0006386)2.72677461
103establishment of integrated proviral latency (GO:0075713)2.72045588
104substantia nigra development (GO:0021762)2.71956288
105replication fork processing (GO:0031297)2.71733017
1067-methylguanosine mRNA capping (GO:0006370)2.71411842
107regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.71205006
108purine nucleobase biosynthetic process (GO:0009113)2.70773381
109regulation of protein kinase A signaling (GO:0010738)2.70715940
110platelet dense granule organization (GO:0060155)2.70600153
111histone mRNA metabolic process (GO:0008334)2.70331449
112axonal fasciculation (GO:0007413)2.70090159
113protein localization to mitochondrion (GO:0070585)2.69399519
114dendrite development (GO:0016358)2.68408220
115somatic hypermutation of immunoglobulin genes (GO:0016446)2.68358485
116somatic diversification of immune receptors via somatic mutation (GO:0002566)2.68358485
117RNA capping (GO:0036260)2.68061198
1187-methylguanosine RNA capping (GO:0009452)2.68061198
119response to cocaine (GO:0042220)2.66529929
120negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.66269598
121serotonin receptor signaling pathway (GO:0007210)2.65858304
122synaptic transmission, dopaminergic (GO:0001963)2.65839136
123protein K6-linked ubiquitination (GO:0085020)2.64954714
124DNA ligation (GO:0006266)2.64606660
125resolution of meiotic recombination intermediates (GO:0000712)2.62923989
126regulation of mitochondrial translation (GO:0070129)2.62411772
127pyrimidine nucleobase catabolic process (GO:0006208)2.62399907
128kinetochore organization (GO:0051383)2.61411436
129neurotransmitter secretion (GO:0007269)2.60777469
130positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.60522069
131oxidative phosphorylation (GO:0006119)2.59838479
132protein K11-linked ubiquitination (GO:0070979)2.59537674
133neurotransmitter-gated ion channel clustering (GO:0072578)2.59423833
134opioid receptor signaling pathway (GO:0038003)2.58492903
135histone H2A acetylation (GO:0043968)2.54965755
136ribonucleoside triphosphate biosynthetic process (GO:0009201)2.54482930
137positive regulation of response to oxidative stress (GO:1902884)2.54045462
138positive regulation of cellular response to oxidative stress (GO:1900409)2.54045462
139L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.53521509
140DNA damage response, detection of DNA damage (GO:0042769)2.53299423
141maturation of 5.8S rRNA (GO:0000460)2.52905170
142DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.52904317
143positive regulation of mitochondrial fission (GO:0090141)2.52674350
144kinetochore assembly (GO:0051382)2.52468424
145signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.52305543
146signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.52305543
147signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.52305543
148postreplication repair (GO:0006301)2.51736894
149tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.51350539
150RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.51350539
151protein localization to kinetochore (GO:0034501)2.51249942
152regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.51118852
153establishment of viral latency (GO:0019043)2.49740901
154signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.47341256
155intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.47341256
156positive regulation of ligase activity (GO:0051351)2.46778096
157DNA replication-dependent nucleosome assembly (GO:0006335)2.46703939
158DNA replication-dependent nucleosome organization (GO:0034723)2.46703939
159somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.46003647
160isotype switching (GO:0045190)2.46003647
161somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.46003647
162signal transduction involved in cell cycle checkpoint (GO:0072395)2.44357010
163intracellular protein transmembrane import (GO:0044743)2.44041194
164ribonucleoprotein complex disassembly (GO:0032988)2.42435041
165mitotic metaphase plate congression (GO:0007080)2.41777664
166spindle checkpoint (GO:0031577)2.41655240
167regulation of ubiquitin-protein transferase activity (GO:0051438)2.40773423
168signal transduction involved in DNA integrity checkpoint (GO:0072401)2.39925294
169signal transduction involved in DNA damage checkpoint (GO:0072422)2.39925294

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.67149799
2GBX2_23144817_ChIP-Seq_PC3_Human3.74864223
3TAF15_26573619_Chip-Seq_HEK293_Human3.18659602
4E2F4_17652178_ChIP-ChIP_JURKAT_Human2.62550311
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48903191
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38985514
7VDR_22108803_ChIP-Seq_LS180_Human2.33826288
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.33732179
9FUS_26573619_Chip-Seq_HEK293_Human2.32121770
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30710549
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.29663653
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.28663596
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.26895455
14E2F7_22180533_ChIP-Seq_HELA_Human2.25698932
15* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.24453063
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.22797064
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.19915035
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.16168508
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.14025465
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10163734
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09613093
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05973652
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.03989788
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.03854403
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.99967010
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.98962119
27P300_19829295_ChIP-Seq_ESCs_Human1.94817350
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.93410729
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.92749455
30VDR_23849224_ChIP-Seq_CD4+_Human1.90768354
31REST_21632747_ChIP-Seq_MESCs_Mouse1.88038505
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.87355333
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81635733
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80434314
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.76596512
36IGF1R_20145208_ChIP-Seq_DFB_Human1.75540886
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.73154578
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69549207
39MYC_18940864_ChIP-ChIP_HL60_Human1.69113763
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.69098793
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.65888549
42RNF2_27304074_Chip-Seq_NSC_Mouse1.65262514
43EWS_26573619_Chip-Seq_HEK293_Human1.64485781
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.63935105
45FOXP3_21729870_ChIP-Seq_TREG_Human1.62010505
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60260686
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59951907
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59951907
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58148682
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58099983
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.55859166
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54861352
53* ER_23166858_ChIP-Seq_MCF-7_Human1.53175516
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.52990834
55ZNF274_21170338_ChIP-Seq_K562_Hela1.52668418
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52421723
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51449588
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51158069
59* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50262292
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50221144
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48644817
62SMAD4_21799915_ChIP-Seq_A2780_Human1.46883177
63REST_18959480_ChIP-ChIP_MESCs_Mouse1.45516504
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.44296207
65AR_21572438_ChIP-Seq_LNCaP_Human1.40734177
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40645353
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40474610
68* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38185806
69FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.38090929
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37672147
71* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36384727
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.35566581
73ETS1_20019798_ChIP-Seq_JURKAT_Human1.34431408
74IRF1_19129219_ChIP-ChIP_H3396_Human1.33829386
75DCP1A_22483619_ChIP-Seq_HELA_Human1.32452926
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31708117
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31541284
78SOX2_16153702_ChIP-ChIP_HESCs_Human1.31273695
79MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30968925
80JUN_21703547_ChIP-Seq_K562_Human1.30742368
81* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30551367
82SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30264884
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29679288
84TTF2_22483619_ChIP-Seq_HELA_Human1.29074989
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27610042
86CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25344877
87SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24636958
88NANOG_16153702_ChIP-ChIP_HESCs_Human1.23553675
89NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22525173
90E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22499371
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22033409
92* PIAS1_25552417_ChIP-Seq_VCAP_Human1.21919050
93EZH2_27294783_Chip-Seq_ESCs_Mouse1.21444209
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20416991
95AR_21909140_ChIP-Seq_LNCAP_Human1.19668497
96ELK1_19687146_ChIP-ChIP_HELA_Human1.19543286
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.19339234
98RNF2_27304074_Chip-Seq_ESCs_Mouse1.19180040
99MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19049892
100THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15534568
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15213307
102* GABP_19822575_ChIP-Seq_HepG2_Human1.14144197
103SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13915298
104NELFA_20434984_ChIP-Seq_ESCs_Mouse1.13591792
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11889895
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11597901
107RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10891465
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10081954
109RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09499455
110AR_25329375_ChIP-Seq_VCAP_Human1.08595418
111SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06895397
112SOX9_26525672_Chip-Seq_HEART_Mouse1.06881762
113FOXM1_23109430_ChIP-Seq_U2OS_Human1.05640928
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05139435
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04757641
116EZH2_27294783_Chip-Seq_NPCs_Mouse1.04595800
117* RUNX2_22187159_ChIP-Seq_PCA_Human1.04321995
118MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03301218
119* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03135208
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02911754
121CBP_20019798_ChIP-Seq_JUKART_Human1.02911754
122CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.02187412
123TP53_22573176_ChIP-Seq_HFKS_Human1.02037951
124ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01434512
125E2F1_18555785_Chip-Seq_ESCs_Mouse1.00664945
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00438516
127REST_19997604_ChIP-ChIP_NEURONS_Mouse1.00367104
128ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99454832
129CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99200042
130P53_22387025_ChIP-Seq_ESCs_Mouse0.98393123
131HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98158694
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97944922
133* PRDM14_20953172_ChIP-Seq_ESCs_Human0.97781352
134NFE2_27457419_Chip-Seq_LIVER_Mouse0.97781059
135CMYC_18555785_Chip-Seq_ESCs_Mouse0.97196012
136MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96893252
137KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96614707
138SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95671798
139ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94882442
140EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94827014
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93751412
142PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92931221
143E2F1_21310950_ChIP-Seq_MCF-7_Human0.92909555
144ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92401767

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.58955246
2MP0001529_abnormal_vocalization3.44087373
3MP0004859_abnormal_synaptic_plasticity3.23608342
4MP0006276_abnormal_autonomic_nervous3.13459179
5MP0003635_abnormal_synaptic_transmissio3.05931998
6MP0009745_abnormal_behavioral_response2.92951601
7MP0001968_abnormal_touch/_nociception2.89128951
8MP0009046_muscle_twitch2.82512887
9MP0004270_analgesia2.76351620
10MP0002064_seizures2.73040800
11MP0008058_abnormal_DNA_repair2.61147912
12MP0001905_abnormal_dopamine_level2.60424472
13MP0002736_abnormal_nociception_after2.60116452
14MP0002063_abnormal_learning/memory/cond2.59470389
15MP0002572_abnormal_emotion/affect_behav2.57350693
16MP0002735_abnormal_chemical_nociception2.46447482
17MP0002272_abnormal_nervous_system2.41602947
18MP0002734_abnormal_mechanical_nocicepti2.39831566
19MP0001440_abnormal_grooming_behavior2.29034361
20MP0001486_abnormal_startle_reflex2.27469790
21MP0001188_hyperpigmentation2.26092691
22MP0010094_abnormal_chromosome_stability2.24596493
23MP0005423_abnormal_somatic_nervous2.18142774
24MP0001984_abnormal_olfaction2.04537397
25MP0001501_abnormal_sleep_pattern2.04232038
26MP0000778_abnormal_nervous_system2.03712303
27MP0002067_abnormal_sensory_capabilities1.98080879
28MP0002184_abnormal_innervation1.91733169
29MP0009379_abnormal_foot_pigmentation1.91304566
30MP0003890_abnormal_embryonic-extraembry1.81613872
31MP0002733_abnormal_thermal_nociception1.81349537
32MP0004957_abnormal_blastocyst_morpholog1.79681350
33MP0001970_abnormal_pain_threshold1.79552646
34MP0004142_abnormal_muscle_tone1.79081610
35MP0003693_abnormal_embryo_hatching1.78233772
36MP0004924_abnormal_behavior1.77727681
37MP0005386_behavior/neurological_phenoty1.77727681
38MP0002938_white_spotting1.77524246
39MP0003122_maternal_imprinting1.73383553
40MP0002822_catalepsy1.68183273
41MP0002557_abnormal_social/conspecific_i1.61356011
42MP0005646_abnormal_pituitary_gland1.60886376
43MP0001293_anophthalmia1.56847152
44MP0008932_abnormal_embryonic_tissue1.54957924
45MP0005645_abnormal_hypothalamus_physiol1.46079656
46MP0003786_premature_aging1.41101619
47MP0004742_abnormal_vestibular_system1.36379783
48MP0003111_abnormal_nucleus_morphology1.35743381
49MP0003941_abnormal_skin_development1.35319926
50MP0003787_abnormal_imprinting1.33694824
51MP0003937_abnormal_limbs/digits/tail_de1.31065289
52MP0003011_delayed_dark_adaptation1.28914884
53MP0002882_abnormal_neuron_morphology1.27893401
54MP0003077_abnormal_cell_cycle1.27223516
55MP0003567_abnormal_fetal_cardiomyocyte1.25605433
56MP0002066_abnormal_motor_capabilities/c1.25490500
57MP0002876_abnormal_thyroid_physiology1.25158290
58MP0005084_abnormal_gallbladder_morpholo1.25097637
59MP0002102_abnormal_ear_morphology1.24521794
60MP0002163_abnormal_gland_morphology1.23525822
61MP0008995_early_reproductive_senescence1.22018417
62MP0000955_abnormal_spinal_cord1.19714700
63MP0008007_abnormal_cellular_replicative1.19606349
64MP0008057_abnormal_DNA_replication1.18818938
65MP0006292_abnormal_olfactory_placode1.18592401
66MP0003136_yellow_coat_color1.18309806
67MP0005409_darkened_coat_color1.17986160
68MP0004811_abnormal_neuron_physiology1.16743543
69MP0001485_abnormal_pinna_reflex1.16414166
70MP0001963_abnormal_hearing_physiology1.15212498
71MP0004147_increased_porphyrin_level1.14934372
72MP0005499_abnormal_olfactory_system1.14301786
73MP0005394_taste/olfaction_phenotype1.14301786
74MP0000631_abnormal_neuroendocrine_gland1.14134924
75MP0002234_abnormal_pharynx_morphology1.13901178
76MP0005551_abnormal_eye_electrophysiolog1.13425323
77MP0010386_abnormal_urinary_bladder1.12488735
78MP0002751_abnormal_autonomic_nervous1.12365949
79MP0003119_abnormal_digestive_system1.11881535
80MP0002837_dystrophic_cardiac_calcinosis1.11739047
81MP0002638_abnormal_pupillary_reflex1.09636163
82MP0005187_abnormal_penis_morphology1.08327958
83MP0003195_calcinosis1.07101690
84MP0003186_abnormal_redox_activity1.06821087
85MP0000647_abnormal_sebaceous_gland1.06335070
86MP0003879_abnormal_hair_cell1.05751681
87MP0008789_abnormal_olfactory_epithelium1.05615823
88MP0006035_abnormal_mitochondrial_morpho1.04458012
89MP0002090_abnormal_vision1.04013701
90MP0002752_abnormal_somatic_nervous1.03506547
91MP0005171_absent_coat_pigmentation1.02979635
92MP0002233_abnormal_nose_morphology1.01508269
93MP0000026_abnormal_inner_ear1.01266539
94MP0002152_abnormal_brain_morphology1.00272237
95MP0000049_abnormal_middle_ear0.99157869
96MP0001286_abnormal_eye_development0.98991912
97MP0006072_abnormal_retinal_apoptosis0.98796402
98MP0003121_genomic_imprinting0.96459026
99MP0005379_endocrine/exocrine_gland_phen0.96085488
100MP0002653_abnormal_ependyma_morphology0.95820997
101MP0003938_abnormal_ear_development0.95556241
102MP0003137_abnormal_impulse_conducting0.94733087
103MP0008569_lethality_at_weaning0.91883421
104MP0008877_abnormal_DNA_methylation0.91354540
105MP0001502_abnormal_circadian_rhythm0.91325897
106MP0003718_maternal_effect0.90352747
107MP0001986_abnormal_taste_sensitivity0.89875346
108MP0002229_neurodegeneration0.89871495
109MP0002210_abnormal_sex_determination0.88550135
110MP0003329_amyloid_beta_deposits0.86724511
111MP0001929_abnormal_gametogenesis0.84695947
112MP0008872_abnormal_physiological_respon0.84368250
113MP0005391_vision/eye_phenotype0.83393405
114MP0003123_paternal_imprinting0.77508511
115MP0004145_abnormal_muscle_electrophysio0.73949563
116MP0000372_irregular_coat_pigmentation0.73560468
117MP0002069_abnormal_eating/drinking_beha0.71283580
118MP0009697_abnormal_copulation0.69231306
119MP0004885_abnormal_endolymph0.67185220
120MP0003861_abnormal_nervous_system0.65889477
121MP0004215_abnormal_myocardial_fiber0.65176145
122MP0001664_abnormal_digestion0.64458736
123MP0004085_abnormal_heartbeat0.64299047
124MP0005253_abnormal_eye_physiology0.62019204
125MP0006036_abnormal_mitochondrial_physio0.62003811
126MP0000751_myopathy0.61867907
127MP0003634_abnormal_glial_cell0.61507414
128MP0003631_nervous_system_phenotype0.60848026
129MP0004133_heterotaxia0.60402105
130MP0003632_abnormal_nervous_system0.59478435
131MP0000013_abnormal_adipose_tissue0.58599776
132MP0000538_abnormal_urinary_bladder0.58578367
133MP0002160_abnormal_reproductive_system0.58274084
134MP0003315_abnormal_perineum_morphology0.58136369
135MP0001177_atelectasis0.57875667

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.54548001
2Focal motor seizures (HP:0011153)5.50796261
3Abnormal mitochondria in muscle tissue (HP:0008316)4.92871819
4Progressive macrocephaly (HP:0004481)4.79765837
5Mitochondrial inheritance (HP:0001427)4.68272577
6Atonic seizures (HP:0010819)4.21157089
7Acute encephalopathy (HP:0006846)4.16917195
8Increased CSF lactate (HP:0002490)3.99425323
9Increased hepatocellular lipid droplets (HP:0006565)3.75497254
10Abnormality of glycolysis (HP:0004366)3.59855948
11Increased serum pyruvate (HP:0003542)3.59855948
12Hepatocellular necrosis (HP:0001404)3.44605734
13Focal seizures (HP:0007359)3.40726192
14Epileptic encephalopathy (HP:0200134)3.35044025
15Absence seizures (HP:0002121)3.32053408
16Myokymia (HP:0002411)3.26427988
17Limb dystonia (HP:0002451)3.23189054
18Hyperventilation (HP:0002883)3.22677540
19Medial flaring of the eyebrow (HP:0010747)3.20218959
20Gait imbalance (HP:0002141)3.18137319
21Febrile seizures (HP:0002373)3.17443132
22Renal Fanconi syndrome (HP:0001994)3.13305158
23Optic disc pallor (HP:0000543)3.12963461
24Dialeptic seizures (HP:0011146)3.08423385
25Lipid accumulation in hepatocytes (HP:0006561)3.01615684
26Abnormal hair whorl (HP:0010721)2.96759742
27Congenital primary aphakia (HP:0007707)2.93252179
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.87938570
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.85710833
30Pancreatic cysts (HP:0001737)2.83890406
31Neuroendocrine neoplasm (HP:0100634)2.83782939
32Pheochromocytoma (HP:0002666)2.82280125
333-Methylglutaconic aciduria (HP:0003535)2.79947277
34Leukodystrophy (HP:0002415)2.79592792
35Methylmalonic acidemia (HP:0002912)2.78919416
36Nephrogenic diabetes insipidus (HP:0009806)2.77944905
37Colon cancer (HP:0003003)2.77096359
38True hermaphroditism (HP:0010459)2.73138991
39Visual hallucinations (HP:0002367)2.70857013
40Progressive cerebellar ataxia (HP:0002073)2.68519853
41Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.63204305
42Cerebral edema (HP:0002181)2.60324248
43Exercise intolerance (HP:0003546)2.59767137
44Hypothermia (HP:0002045)2.55052167
45Molar tooth sign on MRI (HP:0002419)2.53356139
46Abnormality of midbrain morphology (HP:0002418)2.53356139
47Broad-based gait (HP:0002136)2.51881241
48Genital tract atresia (HP:0001827)2.48076216
49Generalized tonic-clonic seizures (HP:0002069)2.46887313
50Vaginal atresia (HP:0000148)2.46270541
51Respiratory failure (HP:0002878)2.43385156
52Poor suck (HP:0002033)2.41823159
53Hepatic necrosis (HP:0002605)2.41342290
54Increased intramyocellular lipid droplets (HP:0012240)2.38805930
55Hyperglycinemia (HP:0002154)2.37508871
56Meckel diverticulum (HP:0002245)2.32417753
57Delusions (HP:0000746)2.30891955
58Parakeratosis (HP:0001036)2.29324184
59Lactic acidosis (HP:0003128)2.29190354
60Increased serum lactate (HP:0002151)2.29059426
61Abnormality of the labia minora (HP:0012880)2.28199850
62X-linked dominant inheritance (HP:0001423)2.25618005
63Abnormality of the ileum (HP:0001549)2.23789482
64Abnormality of alanine metabolism (HP:0010916)2.22729758
65Hyperalaninemia (HP:0003348)2.22729758
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22729758
67Methylmalonic aciduria (HP:0012120)2.22444242
68Aplasia/Hypoplasia of the uvula (HP:0010293)2.22211357
69Amblyopia (HP:0000646)2.22001664
70Polyphagia (HP:0002591)2.18936579
71Nephronophthisis (HP:0000090)2.18764478
72Respiratory difficulties (HP:0002880)2.18033666
73Progressive inability to walk (HP:0002505)2.17812782
74Abnormal lung lobation (HP:0002101)2.17697308
75Abnormality of serum amino acid levels (HP:0003112)2.17374630
76Congenital, generalized hypertrichosis (HP:0004540)2.12008260
77Septo-optic dysplasia (HP:0100842)2.11609948
78Poor coordination (HP:0002370)2.10514264
79Esotropia (HP:0000565)2.09654566
80Fetal akinesia sequence (HP:0001989)2.07913063
81Abnormality of chromosome stability (HP:0003220)2.06019937
82Intestinal atresia (HP:0011100)2.04838757
83Sensory axonal neuropathy (HP:0003390)2.04461368
84Degeneration of the lateral corticospinal tracts (HP:0002314)2.01810722
85Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01810722
86Exertional dyspnea (HP:0002875)2.00511538
87Abnormality of methionine metabolism (HP:0010901)1.99633966
88Specific learning disability (HP:0001328)1.97342701
89Abnormality of renal resorption (HP:0011038)1.95560469
90Cerebral hypomyelination (HP:0006808)1.94477120
91Inability to walk (HP:0002540)1.94207868
92Decreased activity of mitochondrial respiratory chain (HP:0008972)1.92485977
93Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.92485977
94Optic nerve hypoplasia (HP:0000609)1.92272098
95Abnormality of aspartate family amino acid metabolism (HP:0010899)1.90987900
96Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90748671
97Sclerocornea (HP:0000647)1.87098009
98Volvulus (HP:0002580)1.85919389
99Gaze-evoked nystagmus (HP:0000640)1.85344677
100Abnormal ciliary motility (HP:0012262)1.85182645
101Aplasia/Hypoplasia of the tongue (HP:0010295)1.83945589
102Supernumerary spleens (HP:0009799)1.83414905
103Abnormal respiratory epithelium morphology (HP:0012253)1.82651916
104Abnormal respiratory motile cilium morphology (HP:0005938)1.82651916
105Oligodactyly (hands) (HP:0001180)1.81868464
106Chromsome breakage (HP:0040012)1.81224918
107Anxiety (HP:0000739)1.80982851
108Aplasia/Hypoplasia of the lens (HP:0008063)1.80199668
109Delayed gross motor development (HP:0002194)1.79721248
110Excessive salivation (HP:0003781)1.79407119
111Drooling (HP:0002307)1.79407119
112Lethargy (HP:0001254)1.79295709
113Epileptiform EEG discharges (HP:0011182)1.78424645
114Emotional lability (HP:0000712)1.78278637
115Abnormality of serine family amino acid metabolism (HP:0010894)1.76481423
116Abnormality of glycine metabolism (HP:0010895)1.76481423
117Dynein arm defect of respiratory motile cilia (HP:0012255)1.76120343
118Absent/shortened dynein arms (HP:0200106)1.76120343
119Pendular nystagmus (HP:0012043)1.75141981
120Abnormality of the anterior horn cell (HP:0006802)1.75119895
121Degeneration of anterior horn cells (HP:0002398)1.75119895
122Pancreatic fibrosis (HP:0100732)1.74495002
123Aplasia/Hypoplasia of the tibia (HP:0005772)1.74480070
124Chromosomal breakage induced by crosslinking agents (HP:0003221)1.74413892
125Cortical dysplasia (HP:0002539)1.74092694
126Truncal ataxia (HP:0002078)1.73420523
127Small intestinal stenosis (HP:0012848)1.73316135
128Duodenal stenosis (HP:0100867)1.73316135
129Retinal dysplasia (HP:0007973)1.72579435
130Glycosuria (HP:0003076)1.71251480
131Abnormality of urine glucose concentration (HP:0011016)1.71251480
132Autoamputation (HP:0001218)1.70243432
133Medulloblastoma (HP:0002885)1.69090974
134Abnormality of the renal medulla (HP:0100957)1.68957269
135Abnormality of the duodenum (HP:0002246)1.68679106
136Abnormality of the preputium (HP:0100587)1.67670845
137Anophthalmia (HP:0000528)1.67619764
138Hyperthyroidism (HP:0000836)1.67359980
139Stenosis of the external auditory canal (HP:0000402)1.67084296
140Abnormality of the corticospinal tract (HP:0002492)1.66700126
141Short tibia (HP:0005736)1.66508325
142Protruding tongue (HP:0010808)1.66238728
143Type II lissencephaly (HP:0007260)1.64373266
144Postaxial hand polydactyly (HP:0001162)1.64360223
145Birth length less than 3rd percentile (HP:0003561)1.63848510
146Lissencephaly (HP:0001339)1.63764149
147Bifid tongue (HP:0010297)1.63034695
148Abnormality of placental membranes (HP:0011409)1.62631359
149Amniotic constriction ring (HP:0009775)1.62631359
150Abnormal eating behavior (HP:0100738)1.62536154
151Hyperglycinuria (HP:0003108)1.62247993
152CNS hypomyelination (HP:0003429)1.62179724
153Abnormal pupillary function (HP:0007686)1.61571011
154EEG with generalized epileptiform discharges (HP:0011198)1.61507306

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.33743997
2MAP3K123.48992986
3MAP2K72.96360877
4TRIM282.90167695
5NTRK32.78722599
6NME12.65170406
7MAP3K42.62267781
8PNCK2.57140293
9MARK12.56295565
10EPHA42.28179391
11PLK22.17072097
12VRK22.17057450
13NEK12.08048910
14MAP4K22.06766149
15NUAK12.03447517
16STK161.98779100
17ZAK1.95698594
18CDC71.88863514
19CDK191.77251359
20BCR1.75594153
21MAPK131.72955608
22OXSR11.66477316
23TNIK1.64040592
24GRK51.62167659
25MINK11.61449766
26TTK1.61164565
27BUB11.53080183
28GRK71.52176600
29BMPR1B1.45982271
30MAP2K41.42303738
31ARAF1.42106069
32TSSK61.41041742
33EIF2AK11.40158869
34FRK1.36346684
35CCNB11.31672367
36MST41.30730803
37SRPK11.30306099
38AKT31.28220046
39NTRK21.27060880
40DYRK21.26577528
41BRSK21.25607593
42STK391.25505689
43CSNK1G31.24404060
44LIMK11.23461165
45BMPR21.17021022
46PRPF4B1.16635875
47CAMK2B1.15280635
48ADRBK21.14867476
49PLK11.13536992
50PINK11.10722972
51CSNK1G21.10603733
52MAP3K91.07144855
53VRK11.07113978
54TAF11.06951497
55DAPK11.05959679
56PRKCG1.05796142
57ACVR1B1.05053343
58SIK31.04342568
59CAMK2A1.02371832
60UHMK11.00454627
61EIF2AK30.99146712
62PBK0.98914059
63PLK30.98294879
64GRK10.97258680
65RIPK40.90983456
66MUSK0.88539106
67DYRK30.87783805
68BRAF0.87414541
69WNK30.86981656
70BCKDK0.86238784
71CDK50.85527714
72MKNK20.83783885
73DAPK20.81117676
74CDK140.81086344
75EIF2AK20.80811954
76ADRBK10.77449042
77CDK180.77079454
78MKNK10.74168611
79WEE10.72859683
80CSNK1G10.71153718
81STK38L0.70889714
82INSRR0.69722506
83FGR0.69584283
84CSNK1A1L0.69483537
85CDK150.69456754
86PRKCE0.69238310
87DYRK1A0.67524821
88KSR10.67372266
89PDK40.67335230
90PDK30.67335230
91PHKG20.67024338
92PHKG10.67024338
93ERBB30.66413708
94CDK80.66124560
95NTRK10.64471490
96RPS6KA40.64452244
97MYLK0.64244789
98ATR0.63767301
99CDK11A0.61368763
100CAMK2D0.61107951
101CHEK20.58887210
102AURKB0.58031057
103YES10.57405094
104MAPKAPK50.56007498
105CAMKK20.52706562
106PASK0.51895073
107CAMK2G0.51804247
108TGFBR10.51357343
109NEK20.50853423
110ROCK20.48438963
111PDK20.48129743
112AURKA0.48075453
113TLK10.47948496
114CDK30.47780272
115PTK2B0.47644607
116ATM0.47528393
117FES0.47011406
118NEK60.46245365
119CSNK2A10.45857991
120PKN10.41456085
121PLK40.41417492
122WNK40.41224191
123PRKACA0.40827067
124ERBB40.39946657
125CSNK1A10.39141673
126TIE10.37373498
127ALK0.36513151
128SGK2230.36167964
129SGK4940.36167964
130RPS6KA50.35025859
131PAK60.34033832
132STK30.33361657
133FGFR10.32911671
134BRSK10.32860731
135CSNK2A20.32678663
136CSNK1E0.32247026
137LATS20.31016986
138PAK30.29564951
139PRKACB0.29246038

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.95557945
2Parkinsons disease_Homo sapiens_hsa050124.04362590
3Nicotine addiction_Homo sapiens_hsa050333.79277007
4Proteasome_Homo sapiens_hsa030503.43882529
5Alzheimers disease_Homo sapiens_hsa050103.23085358
6Collecting duct acid secretion_Homo sapiens_hsa049663.01882487
7Huntingtons disease_Homo sapiens_hsa050162.97800619
8Synaptic vesicle cycle_Homo sapiens_hsa047212.74591585
9RNA polymerase_Homo sapiens_hsa030202.25542957
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.24627570
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.09462524
12Ribosome_Homo sapiens_hsa030102.06886480
13Cardiac muscle contraction_Homo sapiens_hsa042601.97917950
14DNA replication_Homo sapiens_hsa030301.95654645
15GABAergic synapse_Homo sapiens_hsa047271.94268417
16Vibrio cholerae infection_Homo sapiens_hsa051101.88968397
17Serotonergic synapse_Homo sapiens_hsa047261.80679124
18Amphetamine addiction_Homo sapiens_hsa050311.80623968
19Propanoate metabolism_Homo sapiens_hsa006401.78692466
20Fanconi anemia pathway_Homo sapiens_hsa034601.77742722
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75596763
22Morphine addiction_Homo sapiens_hsa050321.69407509
23Glutamatergic synapse_Homo sapiens_hsa047241.67354436
24Protein export_Homo sapiens_hsa030601.67223103
25Taste transduction_Homo sapiens_hsa047421.66751895
26Long-term potentiation_Homo sapiens_hsa047201.56906311
27Dopaminergic synapse_Homo sapiens_hsa047281.56765912
28Circadian entrainment_Homo sapiens_hsa047131.54599564
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53104007
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52493784
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46661422
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42726021
33Olfactory transduction_Homo sapiens_hsa047401.42386898
34Phototransduction_Homo sapiens_hsa047441.39014143
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38917944
36Base excision repair_Homo sapiens_hsa034101.33847632
37One carbon pool by folate_Homo sapiens_hsa006701.30082066
38Long-term depression_Homo sapiens_hsa047301.23127534
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.22020637
40Cocaine addiction_Homo sapiens_hsa050301.21943090
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17925256
42Selenocompound metabolism_Homo sapiens_hsa004501.14779425
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11892470
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05130165
45Cell cycle_Homo sapiens_hsa041101.03287329
46Salivary secretion_Homo sapiens_hsa049700.98117883
47Cholinergic synapse_Homo sapiens_hsa047250.97926868
48Rheumatoid arthritis_Homo sapiens_hsa053230.97902302
49Basal transcription factors_Homo sapiens_hsa030220.96852051
50Calcium signaling pathway_Homo sapiens_hsa040200.96201028
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94174861
52Renin secretion_Homo sapiens_hsa049240.93317251
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93066302
54Spliceosome_Homo sapiens_hsa030400.91568696
55Axon guidance_Homo sapiens_hsa043600.91465990
56Folate biosynthesis_Homo sapiens_hsa007900.91029916
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85382751
58Pyrimidine metabolism_Homo sapiens_hsa002400.84367337
59Sulfur metabolism_Homo sapiens_hsa009200.84161009
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83937567
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83763959
62Peroxisome_Homo sapiens_hsa041460.80712947
63Oocyte meiosis_Homo sapiens_hsa041140.79651055
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78293233
65Insulin secretion_Homo sapiens_hsa049110.77327477
66Gap junction_Homo sapiens_hsa045400.76745310
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76447947
68Alcoholism_Homo sapiens_hsa050340.73604737
69Nucleotide excision repair_Homo sapiens_hsa034200.72325278
70Phagosome_Homo sapiens_hsa041450.71548083
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70368743
72Oxytocin signaling pathway_Homo sapiens_hsa049210.70287294
73Tryptophan metabolism_Homo sapiens_hsa003800.70071248
74Glutathione metabolism_Homo sapiens_hsa004800.69937673
75Purine metabolism_Homo sapiens_hsa002300.69632504
76Gastric acid secretion_Homo sapiens_hsa049710.69020887
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67509888
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66066446
79Nitrogen metabolism_Homo sapiens_hsa009100.64969314
80Carbon metabolism_Homo sapiens_hsa012000.61733572
81RNA degradation_Homo sapiens_hsa030180.59845390
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59766311
83beta-Alanine metabolism_Homo sapiens_hsa004100.59430252
84Ether lipid metabolism_Homo sapiens_hsa005650.58827478
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58632382
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.58598974
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58101459
88RNA transport_Homo sapiens_hsa030130.57516418
89Fatty acid metabolism_Homo sapiens_hsa012120.57019063
90Biosynthesis of amino acids_Homo sapiens_hsa012300.56571001
91Fatty acid elongation_Homo sapiens_hsa000620.55593177
92Caffeine metabolism_Homo sapiens_hsa002320.54420006
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52928206
94Regulation of autophagy_Homo sapiens_hsa041400.51913683
95Type I diabetes mellitus_Homo sapiens_hsa049400.49996440
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49774419
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49677650
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49515823
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49207855
100GnRH signaling pathway_Homo sapiens_hsa049120.48914536
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48745740
102Steroid biosynthesis_Homo sapiens_hsa001000.48458481
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.48388607
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46420029
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44548745
106Metabolic pathways_Homo sapiens_hsa011000.44472999
107Pyruvate metabolism_Homo sapiens_hsa006200.44005030
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43959466
109Chemical carcinogenesis_Homo sapiens_hsa052040.41782194
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41357374
111Linoleic acid metabolism_Homo sapiens_hsa005910.41022027
112p53 signaling pathway_Homo sapiens_hsa041150.40328102
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40279448
114Hedgehog signaling pathway_Homo sapiens_hsa043400.40116870
115Retinol metabolism_Homo sapiens_hsa008300.38877229
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38770177
117Fatty acid degradation_Homo sapiens_hsa000710.38102564
118Vitamin B6 metabolism_Homo sapiens_hsa007500.38087136
119Arginine and proline metabolism_Homo sapiens_hsa003300.36799648
120ErbB signaling pathway_Homo sapiens_hsa040120.33770117
121Melanogenesis_Homo sapiens_hsa049160.33531782
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.33332079
123Hippo signaling pathway_Homo sapiens_hsa043900.33185710
124Sphingolipid metabolism_Homo sapiens_hsa006000.32722599
125Circadian rhythm_Homo sapiens_hsa047100.30585766
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29111207
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28937135
128cAMP signaling pathway_Homo sapiens_hsa040240.28915919
129Ras signaling pathway_Homo sapiens_hsa040140.27580141
130Butanoate metabolism_Homo sapiens_hsa006500.27059759
131Epstein-Barr virus infection_Homo sapiens_hsa051690.25539681
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.23622645
133Estrogen signaling pathway_Homo sapiens_hsa049150.21564199
134Mismatch repair_Homo sapiens_hsa034300.21382466
135Non-homologous end-joining_Homo sapiens_hsa034500.21116018
136Autoimmune thyroid disease_Homo sapiens_hsa053200.20207759
137Tyrosine metabolism_Homo sapiens_hsa003500.19419550
138Wnt signaling pathway_Homo sapiens_hsa043100.19320932
139Homologous recombination_Homo sapiens_hsa034400.18068724
140African trypanosomiasis_Homo sapiens_hsa051430.17417780
141Phenylalanine metabolism_Homo sapiens_hsa003600.16185291
142MAPK signaling pathway_Homo sapiens_hsa040100.15692354
143cGMP-PKG signaling pathway_Homo sapiens_hsa040220.14013064
144mRNA surveillance pathway_Homo sapiens_hsa030150.13942904
145Pancreatic secretion_Homo sapiens_hsa049720.13923846

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