UBE2U

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.35369599
2epithelial cilium movement (GO:0003351)8.70701069
3cilium movement (GO:0003341)8.56327698
4chromosome condensation (GO:0030261)8.45940265
5sperm motility (GO:0030317)8.09832889
6DNA packaging (GO:0006323)8.07538127
7multicellular organism reproduction (GO:0032504)8.02180238
8fusion of sperm to egg plasma membrane (GO:0007342)8.02041899
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.66811260
10motile cilium assembly (GO:0044458)7.19581746
11single strand break repair (GO:0000012)7.16273589
12acrosome reaction (GO:0007340)7.13335173
13acrosome assembly (GO:0001675)7.06798008
14protein targeting to Golgi (GO:0000042)6.98621360
15piRNA metabolic process (GO:0034587)6.79379663
16establishment of protein localization to Golgi (GO:0072600)6.70650576
17retrograde transport, vesicle recycling within Golgi (GO:0000301)6.52988262
18sperm-egg recognition (GO:0035036)6.48687442
19response to pheromone (GO:0019236)6.28973143
20reproduction (GO:0000003)6.17536244
21rRNA methylation (GO:0031167)6.14998826
22plasma membrane fusion (GO:0045026)6.03046792
23male meiosis (GO:0007140)5.92865470
24cell wall macromolecule metabolic process (GO:0044036)5.88369638
25cell wall macromolecule catabolic process (GO:0016998)5.88369638
26cell-cell recognition (GO:0009988)5.77536094
27spermatid development (GO:0007286)5.70989683
28regulation of cilium movement (GO:0003352)5.69107550
29binding of sperm to zona pellucida (GO:0007339)5.60323302
30single fertilization (GO:0007338)5.49655714
31phosphatidylethanolamine biosynthetic process (GO:0006646)5.48981857
32ventricular system development (GO:0021591)5.42384520
33regulation of meiosis I (GO:0060631)5.33294227
34phosphatidylethanolamine metabolic process (GO:0046337)5.10242665
35rRNA modification (GO:0000154)5.09201668
36RNA destabilization (GO:0050779)5.03215817
37regulation of centriole replication (GO:0046599)5.00486078
38sexual reproduction (GO:0019953)4.98275493
39DNA methylation involved in gamete generation (GO:0043046)4.94108041
40protein localization to Golgi apparatus (GO:0034067)4.93881592
41sperm capacitation (GO:0048240)4.77733208
42nucleus organization (GO:0006997)4.75854999
43seminiferous tubule development (GO:0072520)4.59643725
44fertilization (GO:0009566)4.55292497
45regulation of Rab GTPase activity (GO:0032313)4.53314028
46positive regulation of Rab GTPase activity (GO:0032851)4.53314028
47axoneme assembly (GO:0035082)4.52271297
48regulation of female gonad development (GO:2000194)4.49624146
49protein localization to cilium (GO:0061512)4.38412196
50GTP biosynthetic process (GO:0006183)4.33784192
51synaptonemal complex organization (GO:0070193)4.32778698
52central nervous system myelination (GO:0022010)4.24047855
53axon ensheathment in central nervous system (GO:0032291)4.24047855
54intraciliary transport (GO:0042073)4.07291238
55male meiosis I (GO:0007141)4.05700051
56left/right pattern formation (GO:0060972)4.04442139
57negative regulation of inclusion body assembly (GO:0090084)3.98118726
58cellular ketone body metabolic process (GO:0046950)3.93197761
59synaptonemal complex assembly (GO:0007130)3.92076181
60microtubule nucleation (GO:0007020)3.78378479
61centrosome duplication (GO:0051298)3.77957353
62microtubule depolymerization (GO:0007019)3.76445236
63ketone body metabolic process (GO:1902224)3.73213332
64microtubule severing (GO:0051013)3.71656018
65spermatogenesis (GO:0007283)3.70656505
66male gamete generation (GO:0048232)3.69336871
67organic cation transport (GO:0015695)3.68581321
68regulation of transcription involved in cell fate commitment (GO:0060850)3.66427347
69glomerular visceral epithelial cell development (GO:0072015)3.66038311
70negative regulation of histone methylation (GO:0031061)3.65815119
71cerebral cortex neuron differentiation (GO:0021895)3.65663426
72nucleoside diphosphate phosphorylation (GO:0006165)3.64117875
73cilium organization (GO:0044782)3.60601496
74spermatid nucleus differentiation (GO:0007289)3.60232055
75cilium assembly (GO:0042384)3.56746666
76calcium ion-dependent exocytosis (GO:0017156)3.51108487
77response to acidic pH (GO:0010447)3.50576283
78cell recognition (GO:0008037)3.49849245
79limb bud formation (GO:0060174)3.48202249
80UTP biosynthetic process (GO:0006228)3.45715055
81gamete generation (GO:0007276)3.44862944
82glomerular epithelial cell development (GO:0072310)3.43947564
83left/right axis specification (GO:0070986)3.42563554
84cellular response to pH (GO:0071467)3.40456174
85multicellular organismal movement (GO:0050879)3.39641310
86musculoskeletal movement (GO:0050881)3.39641310
87histone exchange (GO:0043486)3.38710387
88cilium morphogenesis (GO:0060271)3.36975218
89chromosome organization involved in meiosis (GO:0070192)3.29256686
90histone H3-K9 demethylation (GO:0033169)3.27889533
91synapsis (GO:0007129)3.24136209
92regulation of microtubule-based movement (GO:0060632)3.18661580
93chromatin silencing (GO:0006342)3.17090730
94Golgi to endosome transport (GO:0006895)3.16034554
95nuclear pore complex assembly (GO:0051292)3.15563572
96female gamete generation (GO:0007292)3.15367958
97protein polyglutamylation (GO:0018095)3.15158264
98regulation of DNA methylation (GO:0044030)3.14441725
99multicellular organismal development (GO:0007275)3.12090034
100germ cell development (GO:0007281)3.11562475
101cellular process involved in reproduction in multicellular organism (GO:0022412)3.09407768
102cellular component assembly involved in morphogenesis (GO:0010927)3.09364108
103UTP metabolic process (GO:0046051)3.08117066
104regulation of histone H3-K9 methylation (GO:0051570)3.07004964
105meiotic cell cycle process (GO:1903046)3.06021555
106membrane protein intracellular domain proteolysis (GO:0031293)3.01391007
107polyol transport (GO:0015791)3.00041785
108regulation of inclusion body assembly (GO:0090083)2.98684305
109meiosis I (GO:0007127)2.98525227
110polyamine biosynthetic process (GO:0006596)2.96745737
111glycerol ether metabolic process (GO:0006662)2.96135884
112long-chain fatty acid biosynthetic process (GO:0042759)2.93296490
113sensory perception of smell (GO:0007608)2.92934738
114peptidyl-threonine dephosphorylation (GO:0035970)2.91784261
115positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.91574086
116detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.89347166
117calcium ion import (GO:0070509)2.86382260
118genitalia morphogenesis (GO:0035112)2.84906262
119meiotic nuclear division (GO:0007126)2.76762973
120presynaptic membrane assembly (GO:0097105)2.72360253
121startle response (GO:0001964)2.72117244
122multicellular organismal reproductive process (GO:0048609)2.71161128
123otic vesicle formation (GO:0030916)2.69470686
124keratinocyte development (GO:0003334)2.69031898
125neuron cell-cell adhesion (GO:0007158)2.68948887
126response to methylmercury (GO:0051597)2.68099457
127neuron remodeling (GO:0016322)2.67779412
128centriole replication (GO:0007099)2.65964315
129negative regulation of execution phase of apoptosis (GO:1900118)2.63340171
130guanosine-containing compound biosynthetic process (GO:1901070)2.62369106
131meiotic cell cycle (GO:0051321)2.61864315
132microtubule polymerization or depolymerization (GO:0031109)2.59251882
133centriole assembly (GO:0098534)2.56605477
134microtubule-based movement (GO:0007018)2.56592609
135fatty acid elongation (GO:0030497)2.56404475
136eye photoreceptor cell differentiation (GO:0001754)2.53816112
137photoreceptor cell differentiation (GO:0046530)2.53816112
138positive regulation of protein kinase C signaling (GO:0090037)2.53583473
139spinal cord motor neuron differentiation (GO:0021522)2.52472782
140regulation of timing of cell differentiation (GO:0048505)2.52034443
141CTP metabolic process (GO:0046036)2.49342089
142CTP biosynthetic process (GO:0006241)2.49342089
143glycerol metabolic process (GO:0006071)2.45712222
144peptidyl-glutamic acid modification (GO:0018200)2.44657834
145presynaptic membrane organization (GO:0097090)2.44088142
146alditol metabolic process (GO:0019400)2.43519008
147nonmotile primary cilium assembly (GO:0035058)2.41521465
148regulation of cytokine production involved in inflammatory response (GO:1900015)2.39598436
149cilium or flagellum-dependent cell motility (GO:0001539)10.6534363

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.82207168
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.07802927
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.95193795
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.77174585
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.66664759
6GBX2_23144817_ChIP-Seq_PC3_Human2.87533622
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.84376932
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.83641003
9TAF15_26573619_Chip-Seq_HEK293_Human2.52734311
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.50549811
11VDR_22108803_ChIP-Seq_LS180_Human2.48674633
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44426815
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.41965286
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.39753346
15* IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.30611149
16* CBP_20019798_ChIP-Seq_JUKART_Human2.30611149
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.26852384
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23454583
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.20245143
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03953663
21DROSHA_22980978_ChIP-Seq_HELA_Human1.95752796
22SUZ12_27294783_Chip-Seq_NPCs_Mouse1.94686842
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.90992853
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.89383002
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85096739
26NFE2_27457419_Chip-Seq_LIVER_Mouse1.83814003
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82838312
28NANOG_20526341_ChIP-Seq_ESCs_Human1.79950483
29RNF2_27304074_Chip-Seq_NSC_Mouse1.78894563
30VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.71666267
31ARNT_22903824_ChIP-Seq_MCF-7_Human1.69268897
32WDR5_24793694_ChIP-Seq_LNCAP_Human1.67679875
33SMAD4_21741376_ChIP-Seq_EPCs_Human1.67540963
34* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65625426
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64595534
36EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.63485732
37* NANOG_18555785_Chip-Seq_ESCs_Mouse1.62448525
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62296662
39* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.61728828
40RAC3_21632823_ChIP-Seq_H3396_Human1.60939935
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.59440336
42EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.58090939
43TAL1_26923725_Chip-Seq_HPCs_Mouse1.54516285
44ERA_21632823_ChIP-Seq_H3396_Human1.52429515
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.52170897
46* AR_25329375_ChIP-Seq_VCAP_Human1.51882999
47ER_23166858_ChIP-Seq_MCF-7_Human1.51696043
48P53_22387025_ChIP-Seq_ESCs_Mouse1.50579442
49MYC_19829295_ChIP-Seq_ESCs_Human1.49911356
50* P300_19829295_ChIP-Seq_ESCs_Human1.48957394
51EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.48255616
52ERG_20517297_ChIP-Seq_VCAP_Human1.47351603
53BP1_19119308_ChIP-ChIP_Hs578T_Human1.47282129
54* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.46307318
55SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.45667791
56CMYC_18555785_Chip-Seq_ESCs_Mouse1.44541533
57KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.44419763
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44048424
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44048424
60TAF2_19829295_ChIP-Seq_ESCs_Human1.43068952
61EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.42660558
62JARID2_20064375_ChIP-Seq_MESCs_Mouse1.42235334
63REST_21632747_ChIP-Seq_MESCs_Mouse1.41852321
64P300_18555785_Chip-Seq_ESCs_Mouse1.41291549
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.41213754
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39898086
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.39771286
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39695004
69RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.39210655
70FUS_26573619_Chip-Seq_HEK293_Human1.38843461
71STAT3_23295773_ChIP-Seq_U87_Human1.37970181
72* STAT3_18555785_Chip-Seq_ESCs_Mouse1.37825483
73RUNX1_27457419_Chip-Seq_LIVER_Mouse1.37636949
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37230776
75EED_16625203_ChIP-ChIP_MESCs_Mouse1.36822168
76* E2F1_18555785_Chip-Seq_ESCs_Mouse1.36512249
77* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36111333
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.36077898
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35658626
80* OCT4_18555785_Chip-Seq_ESCs_Mouse1.35115455
81SMAD4_21799915_ChIP-Seq_A2780_Human1.34898553
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34559243
83* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.34291943
84SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34243467
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.33889154
86KDM2B_26808549_Chip-Seq_REH_Human1.33755636
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31382732
88TP53_18474530_ChIP-ChIP_U2OS_Human1.31361024
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31048150
90GATA3_21878914_ChIP-Seq_MCF-7_Human1.30907240
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30834534
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30594535
93SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.29422244
94KLF4_18555785_Chip-Seq_ESCs_Mouse1.28938984
95SOX2_18555785_Chip-Seq_ESCs_Mouse1.28545219
96NMYC_18555785_Chip-Seq_ESCs_Mouse1.28308316
97OCT4_21477851_ChIP-Seq_ESCs_Mouse1.25895519
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.25867731
99NANOG_19829295_ChIP-Seq_ESCs_Human1.25573886
100SOX2_19829295_ChIP-Seq_ESCs_Human1.25573886
101ELF1_20517297_ChIP-Seq_JURKAT_Human1.24782091
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24755413
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24693267
104* RUNX2_22187159_ChIP-Seq_PCA_Human1.24319512
105* SMAD3_21741376_ChIP-Seq_ESCs_Human1.24095371
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23703549
107ESRRB_18555785_Chip-Seq_ESCs_Mouse1.23641847
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23460548
109SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23448828
110SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.23252371
111SMRT_27268052_Chip-Seq_Bcells_Human1.23100643
112SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22557117
113KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.22054572
114SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21928577
115OCT4_20526341_ChIP-Seq_ESCs_Human1.21119918
116PU1_27457419_Chip-Seq_LIVER_Mouse1.20747619
117ZFX_18555785_Chip-Seq_ESCs_Mouse1.20743353
118* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.19645846
119TP63_19390658_ChIP-ChIP_HaCaT_Human1.19321842
120CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.18889121
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18494858
122SALL1_21062744_ChIP-ChIP_HESCs_Human1.18438264
123KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17452723
124SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17429234
125ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17169369
126* RBPJ_21746931_ChIP-Seq_IB4_Human1.17165147
127* HNFA_21074721_ChIP-Seq_CACO-2_Human1.16947857
128SMAD1_18555785_Chip-Seq_ESCs_Mouse1.16563828
129BCL6_27268052_Chip-Seq_Bcells_Human1.15701491
130ZNF274_21170338_ChIP-Seq_K562_Hela1.15507243
131RNF2_27304074_Chip-Seq_ESCs_Mouse1.15467187
132CEBPB_22108803_ChIP-Seq_LS180_Human1.15304793
133FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15248394
134TDRD3_21172665_ChIP-Seq_MCF-7_Human1.15159520
135SMAD4_21741376_ChIP-Seq_HESCs_Human1.14695106
136MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14460551
137* NFYB_21822215_ChIP-Seq_K562_Human1.13886174
138CTCF_18555785_Chip-Seq_ESCs_Mouse1.13642105
139RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13622462
140GATA1_26923725_Chip-Seq_HPCs_Mouse1.13510533
141CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13218501
142CTCF_20526341_ChIP-Seq_ESCs_Human1.12922993
143SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12452344
144EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11670777
145* ETV1_20927104_ChIP-Seq_GIST48_Human1.11167195
146ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10383896
147PHF8_20622854_ChIP-Seq_HELA_Human1.10108951
148BCOR_27268052_Chip-Seq_Bcells_Human1.09924405
149BCAT_22108803_ChIP-Seq_LS180_Human1.09657788
150NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09647760
151TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09636117
152* TBL1_22424771_ChIP-Seq_293T_Human1.09548623
153FOXA1_25329375_ChIP-Seq_VCAP_Human1.09427093
154FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09427093
155STAT1_17558387_ChIP-Seq_HELA_Human1.09091702
156GF1_26923725_Chip-Seq_HPCs_Mouse1.08936873
157TCF4_23295773_ChIP-Seq_U87_Human1.08903987
158NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08757136
159RUNX1_26923725_Chip-Seq_HPCs_Mouse1.07963667
160RNF2_18974828_ChIP-Seq_MESCs_Mouse1.07673166
161EZH2_18974828_ChIP-Seq_MESCs_Mouse1.07673166
162E2F1_20622854_ChIP-Seq_HELA_Human1.07217334
163P53_21459846_ChIP-Seq_SAOS-2_Human1.06642799
164AHR_22903824_ChIP-Seq_MCF-7_Human1.05715334
165* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04604094
166* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.04491067
167TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.04374152
168PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04128133
169HOXB7_26014856_ChIP-Seq_BT474_Human1.04090746
170OCT1_27270436_Chip-Seq_PROSTATE_Human1.03974476
171P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.03841152
172SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03551266
173SOX2_22085726_ChIP-Seq_NPCs_Mouse1.03471539

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.22171614
2MP0003878_abnormal_ear_physiology4.58322530
3MP0005377_hearing/vestibular/ear_phenot4.58322530
4MP0003698_abnormal_male_reproductive3.18042450
5MP0001348_abnormal_lacrimal_gland2.91925635
6MP0001984_abnormal_olfaction2.91885243
7MP0003136_yellow_coat_color2.81335508
8MP0002102_abnormal_ear_morphology2.70651595
9MP0001929_abnormal_gametogenesis2.67252717
10MP0003879_abnormal_hair_cell2.42854151
11MP0003880_abnormal_central_pattern2.38432615
12MP0000566_synostosis2.29292006
13MP0008877_abnormal_DNA_methylation2.19842745
14MP0003646_muscle_fatigue2.18122709
15MP0009046_muscle_twitch2.17391902
16MP0005409_darkened_coat_color2.12944078
17MP0002138_abnormal_hepatobiliary_system2.11018766
18MP0005395_other_phenotype2.10171902
19MP0006292_abnormal_olfactory_placode2.09175296
20MP0001486_abnormal_startle_reflex2.06611340
21MP0008789_abnormal_olfactory_epithelium2.03828309
22MP0001188_hyperpigmentation1.97877618
23MP0004742_abnormal_vestibular_system1.92945918
24MP0002234_abnormal_pharynx_morphology1.89342148
25MP0000372_irregular_coat_pigmentation1.85868652
26MP0002132_abnormal_respiratory_system1.85736806
27MP0002210_abnormal_sex_determination1.77878397
28MP0005646_abnormal_pituitary_gland1.77458639
29MP0005451_abnormal_body_composition1.73690413
30MP0003195_calcinosis1.64830530
31MP0002161_abnormal_fertility/fecundity1.64644439
32MP0005551_abnormal_eye_electrophysiolog1.56677832
33MP0001440_abnormal_grooming_behavior1.56234772
34MP0005394_taste/olfaction_phenotype1.51508994
35MP0005499_abnormal_olfactory_system1.51508994
36MP0003950_abnormal_plasma_membrane1.47127242
37MP0009379_abnormal_foot_pigmentation1.45385868
38MP0005423_abnormal_somatic_nervous1.45312496
39MP0003938_abnormal_ear_development1.44418042
40MP0000026_abnormal_inner_ear1.42827552
41MP0002272_abnormal_nervous_system1.42406850
42MP0002736_abnormal_nociception_after1.38061395
43MP0002876_abnormal_thyroid_physiology1.37377938
44MP0001145_abnormal_male_reproductive1.37165454
45MP0002735_abnormal_chemical_nociception1.36999480
46MP0004381_abnormal_hair_follicle1.36245011
47MP0009745_abnormal_behavioral_response1.35092292
48MP0001905_abnormal_dopamine_level1.33251594
49MP0003011_delayed_dark_adaptation1.32765287
50MP0001968_abnormal_touch/_nociception1.32527641
51MP0005670_abnormal_white_adipose1.32243454
52MP0003077_abnormal_cell_cycle1.31768152
53MP0004142_abnormal_muscle_tone1.30181231
54MP0002572_abnormal_emotion/affect_behav1.29447387
55MP0000653_abnormal_sex_gland1.26986386
56MP0001963_abnormal_hearing_physiology1.26117090
57MP0001485_abnormal_pinna_reflex1.25522235
58MP0001986_abnormal_taste_sensitivity1.24423164
59MP0000920_abnormal_myelination1.24329116
60MP0005408_hypopigmentation1.23387911
61MP0002734_abnormal_mechanical_nocicepti1.22357577
62MP0002249_abnormal_larynx_morphology1.22300699
63MP0001529_abnormal_vocalization1.21232097
64MP0002064_seizures1.20711764
65MP0000778_abnormal_nervous_system1.19411229
66MP0002822_catalepsy1.18453012
67MP0005647_abnormal_sex_gland1.16057446
68MP0006276_abnormal_autonomic_nervous1.15282885
69MP0005310_abnormal_salivary_gland1.14651489
70MP0002067_abnormal_sensory_capabilities1.14508624
71MP0005623_abnormal_meninges_morphology1.14225715
72MP0003699_abnormal_female_reproductive1.14047371
73MP0002282_abnormal_trachea_morphology1.13438553
74MP0004019_abnormal_vitamin_homeostasis1.12375428
75MP0003718_maternal_effect1.11755725
76MP0000631_abnormal_neuroendocrine_gland1.11242172
77MP0003635_abnormal_synaptic_transmissio1.08538120
78MP0002557_abnormal_social/conspecific_i1.07004130
79MP0009780_abnormal_chondrocyte_physiolo1.06486655
80MP0008995_early_reproductive_senescence1.05372994
81MP0002752_abnormal_somatic_nervous1.03764007
82MP0002160_abnormal_reproductive_system1.02374335
83MP0005379_endocrine/exocrine_gland_phen1.01788906
84MP0005645_abnormal_hypothalamus_physiol1.00457176
85MP0000049_abnormal_middle_ear0.98091006
86MP0002139_abnormal_hepatobiliary_system0.98068533
87MP0002638_abnormal_pupillary_reflex0.95712934
88MP0009250_abnormal_appendicular_skeleto0.95378089
89MP0001661_extended_life_span0.95260342
90MP0008875_abnormal_xenobiotic_pharmacok0.93000328
91MP0001346_abnormal_lacrimal_gland0.92694126
92MP0003690_abnormal_glial_cell0.91338418
93MP0006072_abnormal_retinal_apoptosis0.89517486
94MP0002063_abnormal_learning/memory/cond0.89138420
95MP0002653_abnormal_ependyma_morphology0.88999057
96MP0005085_abnormal_gallbladder_physiolo0.88844576
97MP0002184_abnormal_innervation0.88169195
98MP0009697_abnormal_copulation0.86827602
99MP0005171_absent_coat_pigmentation0.86616131
100MP0001501_abnormal_sleep_pattern0.86556973
101MP0004043_abnormal_pH_regulation0.86063812
102MP0005253_abnormal_eye_physiology0.85234693
103MP0002277_abnormal_respiratory_mucosa0.83791997
104MP0004270_analgesia0.82683587
105MP0002229_neurodegeneration0.82467272
106MP0001765_abnormal_ion_homeostasis0.81407294
107MP0010386_abnormal_urinary_bladder0.81209355
108MP0004133_heterotaxia0.80433928
109MP0000462_abnormal_digestive_system0.80049157
110MP0004859_abnormal_synaptic_plasticity0.77771109
111MP0008260_abnormal_autophagy0.77491571
112MP0003937_abnormal_limbs/digits/tail_de0.76981250
113MP0000678_abnormal_parathyroid_gland0.75963664
114MP0004885_abnormal_endolymph0.75091681
115MP0005248_abnormal_Harderian_gland0.73776652
116MP0009115_abnormal_fat_cell0.73646716
117MP0005195_abnormal_posterior_eye0.73503920
118MP0001970_abnormal_pain_threshold0.72655633
119MP0000015_abnormal_ear_pigmentation0.70314701
120MP0004134_abnormal_chest_morphology0.70109934
121MP0002882_abnormal_neuron_morphology0.69733618
122MP0002127_abnormal_cardiovascular_syste0.68330222
123MP0005360_urolithiasis0.67895660
124MP0000534_abnormal_ureter_morphology0.63150287
125MP0003119_abnormal_digestive_system0.59679530
126MP0010234_abnormal_vibrissa_follicle0.59322104
127MP0001666_abnormal_nutrient_absorption0.58484634
128MP0004085_abnormal_heartbeat0.58370440
129MP0001293_anophthalmia0.55829056
130MP0000681_abnormal_thyroid_gland0.55508370
131MP0002928_abnormal_bile_duct0.53202608
132MP0010030_abnormal_orbit_morphology0.53197186
133MP0003693_abnormal_embryo_hatching0.51562087
134MP0001324_abnormal_eye_pigmentation0.50016738
135MP0003183_abnormal_peptide_metabolism0.49661345
136MP0010307_abnormal_tumor_latency0.48198594
137MP0001119_abnormal_female_reproductive0.47761178
138MP0003252_abnormal_bile_duct0.46892449
139MP0000230_abnormal_systemic_arterial0.46799954
140MP0005167_abnormal_blood-brain_barrier0.44570399
141MP0005666_abnormal_adipose_tissue0.44184923
142MP0005391_vision/eye_phenotype0.43195417
143MP0004084_abnormal_cardiac_muscle0.42494136
144MP0004233_abnormal_muscle_weight0.42488673
145MP0004957_abnormal_blastocyst_morpholog0.41703027
146MP0000955_abnormal_spinal_cord0.39843719
147MP0002163_abnormal_gland_morphology0.39476781
148MP0009053_abnormal_anal_canal0.39196133
149MP0004036_abnormal_muscle_relaxation0.38102089
150MP0005636_abnormal_mineral_homeostasis0.35332823
151MP0005535_abnormal_body_temperature0.34364223
152MP0002095_abnormal_skin_pigmentation0.33437024

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.58080537
2Severe visual impairment (HP:0001141)7.62435712
3Abnormal ciliary motility (HP:0012262)7.61051004
4Abnormal respiratory epithelium morphology (HP:0012253)7.58328339
5Abnormal respiratory motile cilium morphology (HP:0005938)7.58328339
6Rhinitis (HP:0012384)6.66936197
7Chronic bronchitis (HP:0004469)5.46681109
8Asymmetric septal hypertrophy (HP:0001670)4.64488995
9Attenuation of retinal blood vessels (HP:0007843)4.64140636
10Bony spicule pigmentary retinopathy (HP:0007737)4.47090412
11Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.34367053
12Abnormality of macular pigmentation (HP:0008002)4.33954722
13Cone-rod dystrophy (HP:0000548)4.30657340
14Tubulointerstitial nephritis (HP:0001970)4.04914773
15Impulsivity (HP:0100710)4.01864309
16Nephronophthisis (HP:0000090)3.71570821
17Aplasia/Hypoplasia of the earlobes (HP:0009906)3.68809024
18Infertility (HP:0000789)3.65152322
19Osteomalacia (HP:0002749)3.61603367
20Bronchiectasis (HP:0002110)3.55831359
21Resting tremor (HP:0002322)3.45682253
22Abnormality of the renal medulla (HP:0100957)3.43194217
23Abnormal rod and cone electroretinograms (HP:0008323)3.30855350
24Facial shape deformation (HP:0011334)3.12749483
25Potter facies (HP:0002009)3.12749483
26Truncal obesity (HP:0001956)3.11025996
27Enlarged epiphyses (HP:0010580)3.07145764
28Nasal polyposis (HP:0100582)2.95938584
29Generalized aminoaciduria (HP:0002909)2.90019121
30Progressive sensorineural hearing impairment (HP:0000408)2.89620638
31Recurrent sinusitis (HP:0011108)2.88927339
32Hypoalphalipoproteinemia (HP:0003233)2.83348935
33Medial flaring of the eyebrow (HP:0010747)2.82593095
34Abnormality of midbrain morphology (HP:0002418)2.80210746
35Molar tooth sign on MRI (HP:0002419)2.80210746
36Hypoplasia of the thymus (HP:0000778)2.78384873
37Tubulointerstitial abnormality (HP:0001969)2.78210804
38Fibular hypoplasia (HP:0003038)2.78125540
39Aplasia/Hypoplasia of the fovea (HP:0008060)2.77560291
40Hypoplasia of the fovea (HP:0007750)2.77560291
41Postural instability (HP:0002172)2.63672075
42Hypoplastic ischia (HP:0003175)2.63403371
43Bronchitis (HP:0012387)2.62299356
44Congenital sensorineural hearing impairment (HP:0008527)2.57175973
45Menstrual irregularities (HP:0000858)2.55773414
46Portal hypertension (HP:0001409)2.50355687
47Pancreatic fibrosis (HP:0100732)2.49776996
48Abnormality of dental color (HP:0011073)2.48250815
49Abnormality of abdominal situs (HP:0011620)2.47998094
50Abdominal situs inversus (HP:0003363)2.47998094
51Abnormality of the fovea (HP:0000493)2.43352528
52Progressive cerebellar ataxia (HP:0002073)2.42122224
53Renovascular hypertension (HP:0100817)2.37548261
54Amelogenesis imperfecta (HP:0000705)2.36350438
55Congenital hepatic fibrosis (HP:0002612)2.35800145
56Insulin-resistant diabetes mellitus (HP:0000831)2.35021840
57Abnormality of the ischium (HP:0003174)2.33561710
58Retinal dysplasia (HP:0007973)2.33549915
59Abnormality of the renal cortex (HP:0011035)2.32390520
60Abnormality of the hepatic vasculature (HP:0006707)2.27089818
61Postaxial foot polydactyly (HP:0001830)2.26487457
62Horizontal nystagmus (HP:0000666)2.25056542
63Median cleft lip (HP:0000161)2.24672474
64Intellectual disability, moderate (HP:0002342)2.21926816
65Aplasia/Hypoplasia of the macula (HP:0008059)2.21114612
66True hermaphroditism (HP:0010459)2.20070688
67Decreased central vision (HP:0007663)2.20070088
68Subcapsular cataract (HP:0000523)2.17938312
69Myokymia (HP:0002411)2.17622674
70Abnormality of potassium homeostasis (HP:0011042)2.15622049
71Oligodactyly (hands) (HP:0001180)2.15566308
72Abnormality of the costochondral junction (HP:0000919)2.15151507
73Photophobia (HP:0000613)2.13299979
74Abnormality of the nasal mucosa (HP:0000433)2.12845542
75Recurrent otitis media (HP:0000403)2.12222964
76Gait imbalance (HP:0002141)2.08700265
77Abnormality of the dental root (HP:0006486)2.07885776
78Taurodontia (HP:0000679)2.07885776
79Abnormality of permanent molar morphology (HP:0011071)2.07885776
80Abnormality of the dental pulp (HP:0006479)2.07672110
81Abnormality of molar (HP:0011077)2.07365875
82Abnormality of molar morphology (HP:0011070)2.07365875
83Chronic hepatic failure (HP:0100626)2.07007578
84Sensory axonal neuropathy (HP:0003390)2.03721151
85Congenital primary aphakia (HP:0007707)2.02251759
86Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.01556273
87Aplasia/Hypoplasia affecting the retina (HP:0008061)2.00700862
88Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.6561836
89Dynein arm defect of respiratory motile cilia (HP:0012255)10.0065530
90Absent/shortened dynein arms (HP:0200106)10.0065530
91Stage 5 chronic kidney disease (HP:0003774)1.97486312
92Anterior segment dysgenesis (HP:0007700)1.96406884
93Enlarged kidneys (HP:0000105)1.95207419
94Aplasia/Hypoplasia of the lens (HP:0008063)1.95206383
95Increased purine levels (HP:0004368)1.94825055
96Hyperuricemia (HP:0002149)1.94825055
97Renal dysplasia (HP:0000110)1.93971509
98Abnormality of renal resorption (HP:0011038)1.93806170
99Prolonged partial thromboplastin time (HP:0003645)1.92905258
100Genital tract atresia (HP:0001827)1.91484403
101Polydipsia (HP:0001959)1.91111880
102Abnormal drinking behavior (HP:0030082)1.91111880
103Short tibia (HP:0005736)1.90414311
104Vascular calcification (HP:0004934)1.88959256
105Atelectasis (HP:0100750)1.88368204
106Chronic sinusitis (HP:0011109)1.88018700
107Nephrogenic diabetes insipidus (HP:0009806)1.87446490
108Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86928405
109Tubular atrophy (HP:0000092)1.86849046
110Vaginal atresia (HP:0000148)1.85387820
111Aplasia/Hypoplasia of the fibula (HP:0006492)1.85178379
112Supernumerary spleens (HP:0009799)1.84090520
113Neurofibrillary tangles (HP:0002185)1.82549567
114Progressive hearing impairment (HP:0001730)1.81792570
115Aplasia/Hypoplasia of the tibia (HP:0005772)1.81236770
116Postaxial hand polydactyly (HP:0001162)1.78463110
117Hypophosphatemic rickets (HP:0004912)1.77424821
118Lip pit (HP:0100267)1.76854597
119Abnormal spermatogenesis (HP:0008669)1.76803803
120Sandal gap (HP:0001852)1.75967074
121Unilateral renal agenesis (HP:0000122)1.75470335
122Pancreatic cysts (HP:0001737)1.74777766
123Underdeveloped nasal alae (HP:0000430)1.74207702
124Septo-optic dysplasia (HP:0100842)1.70938605
125Pendular nystagmus (HP:0012043)1.67358862
126Tubulointerstitial fibrosis (HP:0005576)1.66873848
127Nephropathy (HP:0000112)1.66198254
128Ventricular tachycardia (HP:0004756)1.65955399
129Abnormality of renal excretion (HP:0011036)1.65790873
130Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.62365235
131Widely patent fontanelles and sutures (HP:0004492)1.62233351
132Duodenal stenosis (HP:0100867)1.61861469
133Small intestinal stenosis (HP:0012848)1.61861469
134Renal cortical cysts (HP:0000803)1.61856423
135Bile duct proliferation (HP:0001408)1.59215492
136Abnormal biliary tract physiology (HP:0012439)1.59215492
137Preaxial hand polydactyly (HP:0001177)1.58828911
138Occipital encephalocele (HP:0002085)1.58593696
139Focal motor seizures (HP:0011153)1.58123390
140Aplasia involving bones of the upper limbs (HP:0009823)1.57081381
141Aplasia of the phalanges of the hand (HP:0009802)1.57081381
142Aplasia involving bones of the extremities (HP:0009825)1.57081381
143Optic nerve hypoplasia (HP:0000609)1.57049059
144Male pseudohermaphroditism (HP:0000037)1.56406827
145Bell-shaped thorax (HP:0001591)1.54193695
146Absent septum pellucidum (HP:0001331)1.54129797
147Azoospermia (HP:0000027)1.53541555
148Cystic liver disease (HP:0006706)1.52374381
149Male infertility (HP:0003251)1.52248628
150Cardiovascular calcification (HP:0011915)1.51783944
151Parakeratosis (HP:0001036)1.51647974
152Upper limb muscle weakness (HP:0003484)1.50796798
153Polyuria (HP:0000103)1.50293870
154Metabolic alkalosis (HP:0200114)1.49403253
155Abnormal urine output (HP:0012590)1.47547924
156Nasolacrimal duct obstruction (HP:0000579)1.45577176
157Aplasia/Hypoplasia of the tongue (HP:0010295)1.45070609
158Hyperkalemia (HP:0002153)1.44956587
159Facial cleft (HP:0002006)1.44610275
160Abnormality of the fibula (HP:0002991)1.42955857
161Poor coordination (HP:0002370)1.42909119
162Hemiparesis (HP:0001269)1.39779463
163Oculomotor apraxia (HP:0000657)1.38842877
164Degeneration of the lateral corticospinal tracts (HP:0002314)1.38265786

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.57334537
2PDK34.46772579
3PDK44.46772579
4PNCK3.94798390
5PLK23.47770744
6STK393.47692593
7DDR23.33134579
8CASK3.25186631
9BRD43.19092822
10MAP3K93.12227307
11PDK23.11402144
12MAPK153.07079108
13BLK2.88136762
14WNK42.62299729
15TNIK2.47077352
16ARAF2.43386445
17MAP3K132.19848689
18MAP4K22.19749998
19PIK3CG1.99971924
20CDK121.97673374
21OXSR11.88036340
22STK161.81996959
23EPHA41.80614892
24MAP2K71.64665123
25CDK71.61611385
26KSR21.60861682
27ICK1.59080197
28MKNK21.56806075
29CDK31.55885776
30PRKD31.48639990
31PKN11.48428735
32PTK2B1.45586299
33MST1R1.44646800
34NTRK31.40190888
35BMPR1B1.38705520
36PDPK11.31840610
37GRK11.28737708
38IRAK11.26102377
39MET1.25155063
40TYRO31.24035778
41MUSK1.22791350
42BMPR21.17974913
43NTRK21.14967758
44MAPKAPK51.11285655
45NUAK11.11060461
46WNK31.10108020
47CDK91.07130277
48STK38L1.06099676
49NEK61.01736179
50INSRR0.97845325
51WNK10.94928970
52MAPK130.93977409
53BCR0.90577214
54MOS0.87841116
55TIE10.87153764
56CAMK2B0.83821685
57ERBB40.83737287
58ADRBK20.81091613
59FGFR20.80731695
60MARK10.80600444
61IRAK20.79304322
62GRK70.78574573
63STK380.78252817
64CAMK2A0.77562243
65MAP3K80.75344385
66CSNK1A1L0.72993955
67FGR0.72280247
68TESK10.72073426
69CSNK1G30.71351995
70CSNK1G10.71325931
71MAP3K140.71072368
72AURKA0.70053139
73DYRK1B0.69302699
74LATS20.69040806
75FRK0.65744059
76BRSK10.65682502
77PRKG20.65419775
78YES10.65078397
79CAMK2D0.64413529
80PBK0.63851493
81CDK20.62350439
82MKNK10.60370147
83EIF2AK20.60132018
84PRKCQ0.59849404
85PRKCG0.59347277
86DYRK1A0.59224652
87CSNK1G20.58316086
88MARK20.58256424
89PLK10.57777262
90DYRK20.57588273
91PRKCE0.57112660
92CAMK2G0.56052982
93CDK10.53961609
94PINK10.53793981
95RIPK40.53197618
96IRAK30.52133898
97AKT30.52026639
98MAP3K40.51683677
99PRKG10.49450939
100TNK20.49296772
101CAMK1D0.49040468
102MAP3K10.48800980
103FES0.47533078
104PRKACA0.45133804
105TAOK30.44988581
106MAP2K40.44635077
107MAPK10.44281809
108EPHB10.42739703
109GSK3B0.42477690
110PRKD20.42209598
111NEK20.42128166
112CAMK10.41532477
113STK240.41458971
114STK30.41397386
115CHEK10.40578512
116BRSK20.40041468
117LATS10.39976821
118ROCK10.39964148
119CAMK1G0.39834507
120ACVR1B0.38944933
121MST40.38278024
122CLK10.37518040
123RPS6KA10.36246561
124MARK30.35621669
125BRAF0.33904323
126PDK10.33849051
127SRPK10.33254768
128RAF10.31072781
129TTK0.30716568
130KIT0.30486590
131PAK30.29380069
132MAPK70.28602972
133DYRK30.28541493
134OBSCN0.28388853
135PRKCZ0.27953386
136GRK50.27876189
137MTOR0.27815146
138PHKG20.26737614
139PHKG10.26737614
140TXK0.25954389
141PRKAA20.25832870
142SGK2230.25371924
143SGK4940.25371924
144PRKCI0.25355437
145PIK3CA0.25118321
146CSNK1D0.24950645
147ZAK0.24685361
148SIK20.24534164
149RPS6KA20.24171635
150CSNK1A10.24132622
151MAPK80.22076674
152JAK30.21959683
153PRKACB0.20877962
154MAP3K110.18087237
155PRKCB0.17863992
156SGK10.17717141
157PLK30.15833371
158MAPK140.15620523
159CHUK0.14178276
160LMTK20.13835027
161NEK90.13765197
162MAPK100.12824797
163ATM0.11757024

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.22235501
2Nicotine addiction_Homo sapiens_hsa050332.60875237
3Oocyte meiosis_Homo sapiens_hsa041142.39287054
4RNA transport_Homo sapiens_hsa030132.31156691
5Linoleic acid metabolism_Homo sapiens_hsa005912.21121929
6Fatty acid elongation_Homo sapiens_hsa000622.18657103
7Ether lipid metabolism_Homo sapiens_hsa005652.17067456
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.15632068
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99066316
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.96751827
11Histidine metabolism_Homo sapiens_hsa003401.88685268
12Phototransduction_Homo sapiens_hsa047441.82139111
13Cell cycle_Homo sapiens_hsa041101.80559213
14Fatty acid biosynthesis_Homo sapiens_hsa000611.78778640
15Propanoate metabolism_Homo sapiens_hsa006401.78016056
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77946990
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.76958901
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.76911936
19Sulfur metabolism_Homo sapiens_hsa009201.70720782
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68473892
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.66358274
22Caffeine metabolism_Homo sapiens_hsa002321.65182019
23Sphingolipid metabolism_Homo sapiens_hsa006001.63337144
24Taste transduction_Homo sapiens_hsa047421.63239512
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63086387
26Arachidonic acid metabolism_Homo sapiens_hsa005901.62646402
27Oxidative phosphorylation_Homo sapiens_hsa001901.60509568
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59726356
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.59162624
30Steroid biosynthesis_Homo sapiens_hsa001001.51415295
31Huntingtons disease_Homo sapiens_hsa050161.49920476
32Pyruvate metabolism_Homo sapiens_hsa006201.43942067
33Chemical carcinogenesis_Homo sapiens_hsa052041.40956482
34Glutamatergic synapse_Homo sapiens_hsa047241.40633609
35Retinol metabolism_Homo sapiens_hsa008301.40038934
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.39579901
37Amphetamine addiction_Homo sapiens_hsa050311.35194615
38Fanconi anemia pathway_Homo sapiens_hsa034601.33705441
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33312728
40Synaptic vesicle cycle_Homo sapiens_hsa047211.30589969
41Inositol phosphate metabolism_Homo sapiens_hsa005621.28486136
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.26391435
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.25244829
44Olfactory transduction_Homo sapiens_hsa047401.23878976
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.23646092
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22258518
47Basal transcription factors_Homo sapiens_hsa030221.18750484
48Morphine addiction_Homo sapiens_hsa050321.18117106
49Pentose and glucuronate interconversions_Homo sapiens_hsa000401.17624718
50Glycerophospholipid metabolism_Homo sapiens_hsa005641.16069052
51Complement and coagulation cascades_Homo sapiens_hsa046101.14399556
52ABC transporters_Homo sapiens_hsa020101.11870350
53Alzheimers disease_Homo sapiens_hsa050101.11826219
54Serotonergic synapse_Homo sapiens_hsa047261.11744195
55PPAR signaling pathway_Homo sapiens_hsa033201.11398531
56Renin secretion_Homo sapiens_hsa049241.10606464
57Calcium signaling pathway_Homo sapiens_hsa040201.10261142
58Dorso-ventral axis formation_Homo sapiens_hsa043201.08663603
59Primary bile acid biosynthesis_Homo sapiens_hsa001201.08308796
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06885107
61Protein digestion and absorption_Homo sapiens_hsa049741.06842506
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05416912
63Cardiac muscle contraction_Homo sapiens_hsa042601.04537889
64Peroxisome_Homo sapiens_hsa041461.01512072
65Butanoate metabolism_Homo sapiens_hsa006501.00445918
66Type II diabetes mellitus_Homo sapiens_hsa049300.99475022
67Vitamin digestion and absorption_Homo sapiens_hsa049770.95185605
68Base excision repair_Homo sapiens_hsa034100.92883659
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92562155
70GABAergic synapse_Homo sapiens_hsa047270.92365382
71Glycerolipid metabolism_Homo sapiens_hsa005610.89390565
72Circadian rhythm_Homo sapiens_hsa047100.88918413
73Mineral absorption_Homo sapiens_hsa049780.88502695
74Collecting duct acid secretion_Homo sapiens_hsa049660.87905243
75Homologous recombination_Homo sapiens_hsa034400.87750600
76beta-Alanine metabolism_Homo sapiens_hsa004100.87118625
77Cocaine addiction_Homo sapiens_hsa050300.86796567
78Salivary secretion_Homo sapiens_hsa049700.86079397
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85682628
80Axon guidance_Homo sapiens_hsa043600.84983571
81Fatty acid metabolism_Homo sapiens_hsa012120.84974428
82Arginine and proline metabolism_Homo sapiens_hsa003300.81912236
83RNA degradation_Homo sapiens_hsa030180.81227722
84Glutathione metabolism_Homo sapiens_hsa004800.80072664
85Parkinsons disease_Homo sapiens_hsa050120.76961320
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76344714
87Protein export_Homo sapiens_hsa030600.75158858
88Mismatch repair_Homo sapiens_hsa034300.74630817
89Circadian entrainment_Homo sapiens_hsa047130.74160487
90Metabolic pathways_Homo sapiens_hsa011000.73864999
91Insulin secretion_Homo sapiens_hsa049110.73111150
92Staphylococcus aureus infection_Homo sapiens_hsa051500.73038263
93Autoimmune thyroid disease_Homo sapiens_hsa053200.72990392
94Arginine biosynthesis_Homo sapiens_hsa002200.72901334
95Tyrosine metabolism_Homo sapiens_hsa003500.72862581
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.71834969
97Allograft rejection_Homo sapiens_hsa053300.71343021
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70925634
99Purine metabolism_Homo sapiens_hsa002300.68993758
100Endocytosis_Homo sapiens_hsa041440.68749273
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.68600069
102cAMP signaling pathway_Homo sapiens_hsa040240.66311800
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65789467
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64869508
105Glucagon signaling pathway_Homo sapiens_hsa049220.64730230
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63877383
107Ovarian steroidogenesis_Homo sapiens_hsa049130.63657338
108Phenylalanine metabolism_Homo sapiens_hsa003600.62279692
109Type I diabetes mellitus_Homo sapiens_hsa049400.62146466
110Nucleotide excision repair_Homo sapiens_hsa034200.59726104
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59107573
112Tryptophan metabolism_Homo sapiens_hsa003800.58442062
113Gastric acid secretion_Homo sapiens_hsa049710.57783462
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.56589837
115Rheumatoid arthritis_Homo sapiens_hsa053230.54982542
116Fat digestion and absorption_Homo sapiens_hsa049750.53641028
117Wnt signaling pathway_Homo sapiens_hsa043100.53252258
118Antigen processing and presentation_Homo sapiens_hsa046120.51501340
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50685556
120Renin-angiotensin system_Homo sapiens_hsa046140.49832534
121Tight junction_Homo sapiens_hsa045300.48014926
122Pancreatic secretion_Homo sapiens_hsa049720.47413235
123Bile secretion_Homo sapiens_hsa049760.47034835
124Regulation of autophagy_Homo sapiens_hsa041400.46582064
125Selenocompound metabolism_Homo sapiens_hsa004500.46367027
126Glycosaminoglycan degradation_Homo sapiens_hsa005310.45066353
127Fatty acid degradation_Homo sapiens_hsa000710.44908935
128mRNA surveillance pathway_Homo sapiens_hsa030150.44646403
129Influenza A_Homo sapiens_hsa051640.43804182
130Folate biosynthesis_Homo sapiens_hsa007900.43779747
131Pentose phosphate pathway_Homo sapiens_hsa000300.43471178
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42566781
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41168494
134Other glycan degradation_Homo sapiens_hsa005110.40887865
135Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40848235
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40075815
137Oxytocin signaling pathway_Homo sapiens_hsa049210.39977699
138Graft-versus-host disease_Homo sapiens_hsa053320.39649501
139Gap junction_Homo sapiens_hsa045400.39315760
140Long-term depression_Homo sapiens_hsa047300.38986371
141* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37867228
142Viral carcinogenesis_Homo sapiens_hsa052030.35386960
143Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32259500
144Cholinergic synapse_Homo sapiens_hsa047250.32156685
145Hedgehog signaling pathway_Homo sapiens_hsa043400.28605730
146Estrogen signaling pathway_Homo sapiens_hsa049150.28341571
147Adherens junction_Homo sapiens_hsa045200.26864235
148Herpes simplex infection_Homo sapiens_hsa051680.25356902
149MAPK signaling pathway_Homo sapiens_hsa040100.25077835
150ECM-receptor interaction_Homo sapiens_hsa045120.21734240

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