UBE2R2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)4.81754941
2positive regulation by symbiont of host defense response (GO:0052509)4.77989947
3modulation by symbiont of host defense response (GO:0052031)4.77989947
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.77989947
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.77989947
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.77989947
7modulation by symbiont of host immune response (GO:0052553)4.77989947
8translational termination (GO:0006415)4.47922754
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.11065617
10L-phenylalanine metabolic process (GO:0006558)4.11065617
11positive regulation of fatty acid beta-oxidation (GO:0032000)3.92941392
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.89896400
13L-phenylalanine catabolic process (GO:0006559)3.89896400
14ribosomal small subunit biogenesis (GO:0042274)3.88462631
15lysine metabolic process (GO:0006553)3.70560467
16lysine catabolic process (GO:0006554)3.70560467
17glyoxylate metabolic process (GO:0046487)3.67048622
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.51603970
19positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.51148171
20cellular protein complex disassembly (GO:0043624)3.48563670
21viral life cycle (GO:0019058)3.46594639
22negative regulation of fibrinolysis (GO:0051918)3.42848372
23positive regulation of fatty acid oxidation (GO:0046321)3.35277745
24leukocyte migration involved in inflammatory response (GO:0002523)3.33691215
25macrophage activation involved in immune response (GO:0002281)3.31461631
26translational elongation (GO:0006414)3.29695406
27protein complex disassembly (GO:0043241)3.29524803
28detection of molecule of bacterial origin (GO:0032490)3.27648260
29midgut development (GO:0007494)3.27071974
30aromatic amino acid family catabolic process (GO:0009074)3.21557042
31heterochromatin organization (GO:0070828)3.21530961
32camera-type eye morphogenesis (GO:0048593)3.21093220
33regulation of fibrinolysis (GO:0051917)3.19032564
34substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.19010623
35substrate-independent telencephalic tangential migration (GO:0021826)3.19010623
36planar cell polarity pathway involved in neural tube closure (GO:0090179)3.16503987
37positive regulation of gastrulation (GO:2000543)3.15915019
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.15756912
39negative regulation of cell killing (GO:0031342)3.15756912
40triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.12054701
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.08881071
42regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.07605239
43body morphogenesis (GO:0010171)3.07477006
44cotranslational protein targeting to membrane (GO:0006613)3.06917948
45positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.06823995
46protein targeting to ER (GO:0045047)3.05832217
47alpha-linolenic acid metabolic process (GO:0036109)3.03845910
48regulation of chromatin binding (GO:0035561)3.01362887
49kynurenine metabolic process (GO:0070189)3.00863604
50regulation of fatty acid beta-oxidation (GO:0031998)2.98610629
51macromolecular complex disassembly (GO:0032984)2.98287764
523-UTR-mediated mRNA stabilization (GO:0070935)2.97352271
53peptidyl-glutamic acid carboxylation (GO:0017187)2.96746915
54protein carboxylation (GO:0018214)2.96746915
55convergent extension (GO:0060026)2.96688324
56regulation of early endosome to late endosome transport (GO:2000641)2.95593622
57establishment of protein localization to endoplasmic reticulum (GO:0072599)2.94333281
58primitive streak formation (GO:0090009)2.93885922
59response to host (GO:0075136)2.93874972
60response to host defenses (GO:0052200)2.93874972
61response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.93874972
62actin-myosin filament sliding (GO:0033275)2.93279672
63muscle filament sliding (GO:0030049)2.93279672
64cysteine metabolic process (GO:0006534)2.90374411
65negative regulation of erythrocyte differentiation (GO:0045647)2.89825309
66glomerular filtration (GO:0003094)2.89381609
67histone H3-K9 demethylation (GO:0033169)2.88385857
68negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.88072929
69response to host immune response (GO:0052572)2.86886081
70response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.86886081
71SMAD protein complex assembly (GO:0007183)2.86455742
72cell-cell junction maintenance (GO:0045217)2.84284945
73basement membrane organization (GO:0071711)2.82718258
74detection of other organism (GO:0098543)2.82170437
75cellular ketone body metabolic process (GO:0046950)2.81319361
76regulation of triglyceride catabolic process (GO:0010896)2.81196642
77regulation of DNA methylation (GO:0044030)2.81122779
78fatty acid transmembrane transport (GO:1902001)2.80976269
79ribosomal small subunit assembly (GO:0000028)2.76259034
80positive regulation of lipid catabolic process (GO:0050996)2.76113994
81chondrocyte proliferation (GO:0035988)2.75513247
82neuron remodeling (GO:0016322)2.75407610
83hippo signaling (GO:0035329)2.75120848
84protein localization to endoplasmic reticulum (GO:0070972)2.72883458
85negative regulation of fatty acid transport (GO:2000192)2.71791445
86axon extension (GO:0048675)2.71767168
87G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.71590454
88sulfur amino acid catabolic process (GO:0000098)2.71477082
89detection of external biotic stimulus (GO:0098581)2.71052830
902-oxoglutarate metabolic process (GO:0006103)2.70883489
91regulation of skeletal muscle contraction (GO:0014819)2.70718406
92renal filtration (GO:0097205)2.69969565
93acetyl-CoA metabolic process (GO:0006084)2.69232501
94fibrinolysis (GO:0042730)2.67205056
95hypotonic response (GO:0006971)2.67121068
96regulation of NFAT protein import into nucleus (GO:0051532)2.66894570
97cellular glucuronidation (GO:0052695)2.66688281
98RNA stabilization (GO:0043489)2.66104688
99mRNA stabilization (GO:0048255)2.66104688
100negative regulation of glial cell proliferation (GO:0060253)2.66104571
101regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.65616156
102Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.64400767
103plasma lipoprotein particle clearance (GO:0034381)2.63756554
104indole-containing compound catabolic process (GO:0042436)2.63731581
105indolalkylamine catabolic process (GO:0046218)2.63731581
106tryptophan catabolic process (GO:0006569)2.63731581
107complement activation, alternative pathway (GO:0006957)2.63508818
108regulation of fatty acid oxidation (GO:0046320)2.62263496
109epoxygenase P450 pathway (GO:0019373)2.61433036
110RNA localization (GO:0006403)2.61196522
111positive regulation of gene expression, epigenetic (GO:0045815)2.60943695
112fatty acid beta-oxidation (GO:0006635)2.60902428
113glucuronate metabolic process (GO:0019585)2.60675168
114uronic acid metabolic process (GO:0006063)2.60675168
115ethanol oxidation (GO:0006069)2.60665537
116middle ear morphogenesis (GO:0042474)2.60027023
117cell migration in hindbrain (GO:0021535)2.59771263
118aldehyde catabolic process (GO:0046185)2.57150531
119carnitine shuttle (GO:0006853)2.57001688
120response to peptidoglycan (GO:0032494)2.56485183
121arginine metabolic process (GO:0006525)2.55796022
122amino-acid betaine metabolic process (GO:0006577)2.55612085
123detection of biotic stimulus (GO:0009595)2.55285969
124tryptophan metabolic process (GO:0006568)2.54810790
125bile acid biosynthetic process (GO:0006699)2.54266602
126neuron projection extension (GO:1990138)2.54146357
127metanephric mesenchyme development (GO:0072075)2.53891994
128detection of bacterium (GO:0016045)2.53553136
129neuron projection extension involved in neuron projection guidance (GO:1902284)2.52757879
130axon extension involved in axon guidance (GO:0048846)2.52757879
131positive regulation of lipid kinase activity (GO:0090218)2.52464751
132regulation of heart morphogenesis (GO:2000826)2.52422572
133short-chain fatty acid metabolic process (GO:0046459)2.51843580
134response to dexamethasone (GO:0071548)2.51776325
135regulation of establishment of planar polarity (GO:0090175)2.51550042
136actin-mediated cell contraction (GO:0070252)2.50317517
137fatty acid oxidation (GO:0019395)2.50012288
138embryonic retina morphogenesis in camera-type eye (GO:0060059)2.49807294
139pyrimidine nucleobase catabolic process (GO:0006208)2.49803572
140maternal placenta development (GO:0001893)2.49570791
141cochlea morphogenesis (GO:0090103)2.49521608
142serine family amino acid catabolic process (GO:0009071)2.49158109
143response to parathyroid hormone (GO:0071107)2.49024146
144fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.48869565
145translational initiation (GO:0006413)2.48701238
146negative regulation of cardiac muscle tissue growth (GO:0055022)2.48594308
147negative regulation of heart growth (GO:0061117)2.48594308
148cerebral cortex radially oriented cell migration (GO:0021799)2.47942774
149regulation of macrophage cytokine production (GO:0010935)2.47373812
150paraxial mesoderm development (GO:0048339)2.46666733
151nucleosome disassembly (GO:0006337)2.46098712
152protein-DNA complex disassembly (GO:0032986)2.46098712
153cardiac myofibril assembly (GO:0055003)2.45557684
154radial glial cell differentiation (GO:0060019)2.44513498
155cellular response to dexamethasone stimulus (GO:0071549)2.44196306
156lipid oxidation (GO:0034440)2.43220138
157protein targeting to membrane (GO:0006612)2.43198294
158pattern specification involved in kidney development (GO:0061004)2.42711618
159sarcomere organization (GO:0045214)2.42391194
160axonal fasciculation (GO:0007413)2.40968485
161endocardial cushion development (GO:0003197)2.40634804
1624-hydroxyproline metabolic process (GO:0019471)2.40589619
163kidney mesenchyme development (GO:0072074)2.40366908
164modification by symbiont of host morphology or physiology (GO:0044003)2.40092461
165positive regulation of Rho protein signal transduction (GO:0035025)2.40080849
166regulation of plasminogen activation (GO:0010755)2.40051157
167high-density lipoprotein particle remodeling (GO:0034375)2.39835469
168lymphangiogenesis (GO:0001946)2.39769973
169embryonic body morphogenesis (GO:0010172)2.39527334
170cell migration involved in heart development (GO:0060973)2.38344053
171plasma membrane repair (GO:0001778)2.38229232
172establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.38095399
173establishment of nucleus localization (GO:0040023)2.38032779
174outer ear morphogenesis (GO:0042473)2.37786963
175positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)2.37757883
176protein heterotrimerization (GO:0070208)2.37115728
177regulation of protein activation cascade (GO:2000257)2.36962785
178neuron recognition (GO:0008038)2.36931400
179desmosome organization (GO:0002934)2.36183702
180microglial cell activation (GO:0001774)2.36025172
181regulation of phosphatidylinositol 3-kinase activity (GO:0043551)2.36012715
182regulation of RNA export from nucleus (GO:0046831)2.35834429
183neuronal stem cell maintenance (GO:0097150)2.35797858
184valine metabolic process (GO:0006573)2.35473973
185negative regulation of toll-like receptor signaling pathway (GO:0034122)2.35166395
186stress fiber assembly (GO:0043149)2.35037622
187negative regulation of histone methylation (GO:0031061)2.34752204
188negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.33473871
189urea metabolic process (GO:0019627)2.33426704
190urea cycle (GO:0000050)2.33426704
191arginine catabolic process (GO:0006527)2.32846840
192ketone body metabolic process (GO:1902224)2.32157314
193aspartate family amino acid catabolic process (GO:0009068)2.31765403
194negative regulation of lipase activity (GO:0060192)2.31476013
195vascular endothelial growth factor signaling pathway (GO:0038084)2.31415195
196pre-miRNA processing (GO:0031054)2.30488303

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.71240445
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.59328248
3EZH2_22144423_ChIP-Seq_EOC_Human5.08124943
4* RXR_22158963_ChIP-Seq_LIVER_Mouse4.15402542
5TRIM28_21343339_ChIP-Seq_HEK293_Human4.12656592
6TP63_17297297_ChIP-ChIP_HaCaT_Human4.11480367
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.69210499
8RARG_19884340_ChIP-ChIP_MEFs_Mouse3.35610148
9LXR_22158963_ChIP-Seq_LIVER_Mouse3.33983081
10CLOCK_20551151_ChIP-Seq_293T_Human3.06359498
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.34449505
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.31714302
13* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.31025144
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.27312715
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.25514021
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.17030897
17TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.12716364
18MYC_22102868_ChIP-Seq_BL_Human2.11734437
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.09849734
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.06462471
21EGR1_23403033_ChIP-Seq_LIVER_Mouse2.05059250
22WT1_19549856_ChIP-ChIP_CCG9911_Human1.97438776
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.93917747
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.93917747
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.93917747
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.93352479
27TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.89380059
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89274242
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.82878867
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.78529364
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.78303882
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.78147076
33* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74784480
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.73687966
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.73432088
36* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.71330335
37OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.69358860
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68809183
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.68561843
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.68459663
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.67164492
42RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.66580021
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65796395
44RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.60959167
45ZNF263_19887448_ChIP-Seq_K562_Human1.58990150
46JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56973848
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.56746176
48VDR_24763502_ChIP-Seq_THP-1_Human1.55270456
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.55104553
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.53501949
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53315748
52NFIB_24661679_ChIP-Seq_LUNG_Mouse1.51390999
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49286216
54TBX20_22080862_ChIP-Seq_HEART_Mouse1.49226874
55TBX20_22328084_ChIP-Seq_HEART_Mouse1.49226874
56* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48802522
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46991022
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45756961
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.45271362
60RNF2_18974828_ChIP-Seq_MESCs_Mouse1.45271362
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44630948
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.44434317
63RING1B_27294783_Chip-Seq_NPCs_Mouse1.42730907
64EP300_21415370_ChIP-Seq_HL-1_Mouse1.39326727
65CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.38898748
66SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38234200
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.37609664
68GATA1_26923725_Chip-Seq_HPCs_Mouse1.37243846
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.33945014
70RACK7_27058665_Chip-Seq_MCF-7_Human1.33620844
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33296553
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32218524
73LXR_22292898_ChIP-Seq_THP-1_Human1.32077751
74KDM2B_26808549_Chip-Seq_DND41_Human1.30611629
75CDX2_20551321_ChIP-Seq_CACO-2_Human1.27116163
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26739294
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.24569628
78* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24431481
79EZH2_27294783_Chip-Seq_ESCs_Mouse1.22962851
80PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21851939
81ISL1_27105846_Chip-Seq_CPCs_Mouse1.21730820
82RING1B_27294783_Chip-Seq_ESCs_Mouse1.21302699
83SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21074465
84JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20715638
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20414211
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20195388
87EGR1_19374776_ChIP-ChIP_THP-1_Human1.18924977
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18462910
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17187263
90ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16877195
91PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.16666325
92TCF7_22412390_ChIP-Seq_EML_Mouse1.16459768
93* FOXO3_23340844_ChIP-Seq_DLD1_Human1.16266544
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14811177
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14767871
96POU5F1_16518401_ChIP-PET_MESCs_Mouse1.14216929
97CBX2_27304074_Chip-Seq_ESCs_Mouse1.13074464
98CTCF_27219007_Chip-Seq_Bcells_Human1.11903013
99SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11170678
100SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11094322
101HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10948730
102ESR2_21235772_ChIP-Seq_MCF-7_Human1.10693952
103TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.10522861
104STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10426634
105CJUN_26792858_Chip-Seq_BT549_Human1.09244799
106SPI1_23127762_ChIP-Seq_K562_Human1.08170461
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07001583
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06823635
109SOX2_20726797_ChIP-Seq_SW620_Human1.04857061
110PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04813011
111ESR1_21235772_ChIP-Seq_MCF-7_Human1.04699474
112NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03933061
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03864374
114* RARB_27405468_Chip-Seq_BRAIN_Mouse1.02699436
115KDM2B_26808549_Chip-Seq_K562_Human1.02171542
116* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01866748
117CREB1_26743006_Chip-Seq_LNCaP_Human1.01277247
118NANOG_21062744_ChIP-ChIP_HESCs_Human1.00464328
119TP53_18474530_ChIP-ChIP_U2OS_Human0.99952078
120MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99271294
121DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99101594
122SA1_27219007_Chip-Seq_ERYTHROID_Human0.98371614
123UBF1/2_26484160_Chip-Seq_HMECs_Human0.98320725
124NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98189465
125NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98189465
126SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98047145
127DPY_21335234_ChIP-Seq_ESCs_Mouse0.97508118
128SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97245554
129TP63_19390658_ChIP-ChIP_HaCaT_Human0.97150149
130TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95667198
131* STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.95593432
132SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95240391
133ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95086297
134ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.94945457
135NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.94890208
136FOXA2_19822575_ChIP-Seq_HepG2_Human0.94851988
137EED_16625203_ChIP-ChIP_MESCs_Mouse0.94325787
138ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94190996
139TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93286853
140* VDR_21846776_ChIP-Seq_THP-1_Human0.92749352
141P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92717822
142WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91599343
143SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91565467
144GF1_26923725_Chip-Seq_HPCs_Mouse0.91525744
145KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91026295
146MYB_21317192_ChIP-Seq_ERMYB_Mouse0.90697580
147BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89666985
148MAF_26560356_Chip-Seq_TH1_Human0.87777929
149* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87097475
150* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87097475
151MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.86740022
152TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86280347
153SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86213558
154BRD4_25478319_ChIP-Seq_HGPS_Human0.86185838
155UTX_26944678_Chip-Seq_JUKART_Human0.85026460
156TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84729105
157RUNX1_26923725_Chip-Seq_HPCs_Mouse0.84687920
158NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84165321

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.60463874
2MP0005409_darkened_coat_color3.37091662
3MP0005360_urolithiasis3.29185161
4MP0003123_paternal_imprinting3.09664113
5MP0003705_abnormal_hypodermis_morpholog3.00703210
6MP0009053_abnormal_anal_canal2.90698621
7MP0008438_abnormal_cutaneous_collagen2.87740847
8MP0006292_abnormal_olfactory_placode2.68914399
9MP0005085_abnormal_gallbladder_physiolo2.53124260
10MP0000778_abnormal_nervous_system2.48843913
11MP0010368_abnormal_lymphatic_system2.42696781
12MP0005275_abnormal_skin_tensile2.34224246
13MP0003121_genomic_imprinting2.26788238
14MP0005365_abnormal_bile_salt2.24907507
15MP0002653_abnormal_ependyma_morphology2.21715918
16MP0003385_abnormal_body_wall2.11889858
17MP0003787_abnormal_imprinting2.10616683
18MP0005503_abnormal_tendon_morphology2.10443870
19MP0003890_abnormal_embryonic-extraembry2.06172908
20MP0004858_abnormal_nervous_system2.02586068
21MP0001293_anophthalmia2.01695445
22MP0003252_abnormal_bile_duct1.96549699
23MP0009250_abnormal_appendicular_skeleto1.95084397
24MP0003303_peritoneal_inflammation1.91417121
25MP0010030_abnormal_orbit_morphology1.91384467
26MP0002837_dystrophic_cardiac_calcinosis1.89763997
27MP0008875_abnormal_xenobiotic_pharmacok1.82231134
28MP0004272_abnormal_basement_membrane1.80859820
29MP0004185_abnormal_adipocyte_glucose1.72928393
30MP0000733_abnormal_muscle_development1.70859738
31MP0001879_abnormal_lymphatic_vessel1.69348954
32MP0000751_myopathy1.62543617
33MP0004859_abnormal_synaptic_plasticity1.59910315
34MP0005499_abnormal_olfactory_system1.58672170
35MP0005394_taste/olfaction_phenotype1.58672170
36MP0005083_abnormal_biliary_tract1.57423408
37MP0004087_abnormal_muscle_fiber1.54993202
38MP0003938_abnormal_ear_development1.53277585
39MP0003861_abnormal_nervous_system1.50302260
40MP0000749_muscle_degeneration1.48538772
41MP0001348_abnormal_lacrimal_gland1.45846329
42MP0003567_abnormal_fetal_cardiomyocyte1.44494798
43MP0003122_maternal_imprinting1.44492842
44MP0004130_abnormal_muscle_cell1.41675510
45MP0001286_abnormal_eye_development1.38638649
46MP0010329_abnormal_lipoprotein_level1.38028467
47MP0002092_abnormal_eye_morphology1.36437287
48MP0005666_abnormal_adipose_tissue1.35639756
49MP0010630_abnormal_cardiac_muscle1.35465364
50MP0005248_abnormal_Harderian_gland1.35200254
51MP0009384_cardiac_valve_regurgitation1.32839182
52MP0001188_hyperpigmentation1.32227584
53MP0003942_abnormal_urinary_system1.31756396
54MP0000955_abnormal_spinal_cord1.31627348
55MP0008789_abnormal_olfactory_epithelium1.30663878
56MP0000759_abnormal_skeletal_muscle1.29030025
57MP0002277_abnormal_respiratory_mucosa1.28793998
58MP0002249_abnormal_larynx_morphology1.28374481
59MP0000762_abnormal_tongue_morphology1.26821595
60MP0005330_cardiomyopathy1.26667259
61MP0002932_abnormal_joint_morphology1.25893886
62MP0003878_abnormal_ear_physiology1.25657563
63MP0005377_hearing/vestibular/ear_phenot1.25657563
64MP0005257_abnormal_intraocular_pressure1.25096773
65MP0008260_abnormal_autophagy1.23239531
66MP0002796_impaired_skin_barrier1.22899992
67MP0003566_abnormal_cell_adhesion1.22741964
68MP0005423_abnormal_somatic_nervous1.22479953
69MP0002282_abnormal_trachea_morphology1.21984710
70MP0003279_aneurysm1.21834868
71MP0003724_increased_susceptibility_to1.20748293
72MP0000537_abnormal_urethra_morphology1.20703280
73MP0000750_abnormal_muscle_regeneration1.18698572
74MP0001849_ear_inflammation1.18689175
75MP0002152_abnormal_brain_morphology1.17758630
76MP0005076_abnormal_cell_differentiation1.15550752
77MP0005332_abnormal_amino_acid1.15399306
78MP0003436_decreased_susceptibility_to1.15072893
79MP0000049_abnormal_middle_ear1.14626344
80MP0002089_abnormal_postnatal_growth/wei1.12743617
81MP0005623_abnormal_meninges_morphology1.12740047
82MP0002233_abnormal_nose_morphology1.11534804
83MP0004510_myositis1.11331932
84MP0005367_renal/urinary_system_phenotyp1.11325014
85MP0000516_abnormal_urinary_system1.11325014
86MP0002106_abnormal_muscle_physiology1.09968086
87MP0003828_pulmonary_edema1.08625366
88MP0004145_abnormal_muscle_electrophysio1.08061823
89MP0005385_cardiovascular_system_phenoty1.07581629
90MP0001544_abnormal_cardiovascular_syste1.07581629
91MP0005451_abnormal_body_composition1.07354023
92MP0003941_abnormal_skin_development1.04427688
93MP0003300_gastrointestinal_ulcer1.03644305
94MP0000767_abnormal_smooth_muscle1.03299967
95MP0005369_muscle_phenotype1.01710429
96MP0002971_abnormal_brown_adipose1.01369197
97MP0002108_abnormal_muscle_morphology1.00155384
98MP0005620_abnormal_muscle_contractility0.99423046
99MP0004084_abnormal_cardiac_muscle0.99342849
100MP0002896_abnormal_bone_mineralization0.98647229
101MP0005375_adipose_tissue_phenotype0.98579616
102MP0000428_abnormal_craniofacial_morphol0.97953451
103MP0006054_spinal_hemorrhage0.97717195
104MP0002128_abnormal_blood_circulation0.97115132
105MP0008775_abnormal_heart_ventricle0.95443262
106MP0006138_congestive_heart_failure0.94841590
107MP0002060_abnormal_skin_morphology0.94390730
108MP0004036_abnormal_muscle_relaxation0.94052454
109MP0001958_emphysema0.93895853
110MP0002116_abnormal_craniofacial_bone0.93799852
111MP0002138_abnormal_hepatobiliary_system0.93748800
112MP0005508_abnormal_skeleton_morphology0.93743640
113MP0003119_abnormal_digestive_system0.93614283
114MP0003091_abnormal_cell_migration0.93563021
115MP0000609_abnormal_liver_physiology0.93357997
116MP0002081_perinatal_lethality0.92955218
117MP0001346_abnormal_lacrimal_gland0.92910892
118MP0002132_abnormal_respiratory_system0.91469581
119MP0000534_abnormal_ureter_morphology0.91243352
120MP0002972_abnormal_cardiac_muscle0.91235185
121MP0005319_abnormal_enzyme/_coenzyme0.90476674
122MP0009672_abnormal_birth_weight0.90091392
123MP0003172_abnormal_lysosome_physiology0.89865944
124MP0005501_abnormal_skin_physiology0.89537829
125MP0002822_catalepsy0.88904846
126MP0009278_abnormal_bone_marrow0.88621016
127MP0000163_abnormal_cartilage_morphology0.88537720
128MP0003115_abnormal_respiratory_system0.86929282
129MP0004811_abnormal_neuron_physiology0.86782460
130MP0003935_abnormal_craniofacial_develop0.86501306
131MP0002085_abnormal_embryonic_tissue0.86097728
132MP0003656_abnormal_erythrocyte_physiolo0.85737720
133MP0003315_abnormal_perineum_morphology0.85620887
134MP0003283_abnormal_digestive_organ0.85408527
135MP0000266_abnormal_heart_morphology0.85226713
136MP0003646_muscle_fatigue0.85157106
137MP0000747_muscle_weakness0.84845114
138MP0002115_abnormal_skeleton_extremities0.84305912
139MP0003755_abnormal_palate_morphology0.83942239
140MP0003329_amyloid_beta_deposits0.81187025
141MP0003195_calcinosis0.81180840
142MP0005187_abnormal_penis_morphology0.79854954
143MP0001340_abnormal_eyelid_morphology0.79638153
144MP0001851_eye_inflammation0.79352360
145MP0002084_abnormal_developmental_patter0.78196538
146MP0002098_abnormal_vibrissa_morphology0.78106286
147MP0002697_abnormal_eye_size0.77337202
148MP0003191_abnormal_cellular_cholesterol0.76649206
149MP0003937_abnormal_limbs/digits/tail_de0.76647967
150MP0002118_abnormal_lipid_homeostasis0.76147743
151MP0009379_abnormal_foot_pigmentation0.75435297
152MP0001299_abnormal_eye_distance/0.75031766
153MP0000566_synostosis0.74983638
154MP0008004_abnormal_stomach_pH0.74931078
155MP0001915_intracranial_hemorrhage0.73936598
156MP0003011_delayed_dark_adaptation0.72406680
157MP0002998_abnormal_bone_remodeling0.72033132
158MP0000432_abnormal_head_morphology0.71014659
159MP0002882_abnormal_neuron_morphology0.69133874
160MP0003690_abnormal_glial_cell0.68907821
161MP0005193_abnormal_anterior_eye0.68600945
162MP0003183_abnormal_peptide_metabolism0.67910297
163MP0002925_abnormal_cardiovascular_devel0.67271394
164MP0001943_abnormal_respiration0.66948367
165MP0005464_abnormal_platelet_physiology0.66278528
166MP0004883_abnormal_blood_vessel0.66249942
167MP0003453_abnormal_keratinocyte_physiol0.66137205
168MP0001529_abnormal_vocalization0.64792932
169MP0002127_abnormal_cardiovascular_syste0.63412674

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)3.94904163
2Protrusio acetabuli (HP:0003179)3.82455682
3Septo-optic dysplasia (HP:0100842)3.47789916
4Type 1 muscle fiber predominance (HP:0003803)3.47251586
5Deep palmar crease (HP:0006191)3.34937189
6Exercise-induced muscle cramps (HP:0003710)3.33854371
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.25057873
8Lymphangioma (HP:0100764)3.18560923
9Right ventricular cardiomyopathy (HP:0011663)3.11964121
10Broad metatarsal (HP:0001783)2.97401063
11Exercise-induced myalgia (HP:0003738)2.93832807
12Muscle fiber inclusion bodies (HP:0100299)2.90936940
13Muscle hypertrophy of the lower extremities (HP:0008968)2.90926655
14Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.89999657
15Supernumerary ribs (HP:0005815)2.87517055
16Obstructive sleep apnea (HP:0002870)2.87487654
17Myoglobinuria (HP:0002913)2.87296177
18Round ear (HP:0100830)2.87279207
19Xanthomatosis (HP:0000991)2.86270008
20Increased connective tissue (HP:0009025)2.83881131
21Shallow orbits (HP:0000586)2.82263525
22Sudden death (HP:0001699)2.81507997
23Hyporeflexia of lower limbs (HP:0002600)2.80346943
24Calf muscle hypertrophy (HP:0008981)2.79571086
25Abnormality of monocarboxylic acid metabolism (HP:0010996)2.74578763
26Premature rupture of membranes (HP:0001788)2.73816241
27Ventricular tachycardia (HP:0004756)2.72056714
28Long palpebral fissure (HP:0000637)2.71520851
29Eczematoid dermatitis (HP:0000976)2.67273929
30Metaphyseal cupping (HP:0003021)2.67161707
31Abnormality of glutamine family amino acid metabolism (HP:0010902)2.66535623
32Partial duplication of thumb phalanx (HP:0009944)2.64251700
33Partial duplication of the phalanx of hand (HP:0009999)2.60122978
34Muscle fiber splitting (HP:0003555)2.55704487
35Back pain (HP:0003418)2.55639579
36Nemaline bodies (HP:0003798)2.52056628
37Intrahepatic cholestasis (HP:0001406)2.48056944
38Ketosis (HP:0001946)2.47084598
39Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.46988842
40Reticulocytopenia (HP:0001896)2.46625384
41Myokymia (HP:0002411)2.43261047
42Asymmetry of the thorax (HP:0001555)2.40301567
43Peritonitis (HP:0002586)2.38014297
44Osteomalacia (HP:0002749)2.37903475
45Vertebral arch anomaly (HP:0008438)2.37756841
46Absent phalangeal crease (HP:0006109)2.37689635
47Distal arthrogryposis (HP:0005684)2.37467828
48Subaortic stenosis (HP:0001682)2.33905943
49Abnormality of the left ventricular outflow tract (HP:0011103)2.33905943
50Hyperammonemia (HP:0001987)2.33712298
51Abnormal hemoglobin (HP:0011902)2.31991166
52Rectal prolapse (HP:0002035)2.31982722
53Abnormality of the calf musculature (HP:0001430)2.31709905
54Epidermoid cyst (HP:0200040)2.29330809
55EMG: myopathic abnormalities (HP:0003458)2.28675301
56Diastasis recti (HP:0001540)2.26535862
57Recurrent gram-negative bacterial infections (HP:0005420)2.26371495
58Abnormality of the parietal bone (HP:0002696)2.26074216
59Wide anterior fontanel (HP:0000260)2.26012294
60Abnormality of the 4th metacarpal (HP:0010012)2.25117143
61Increased variability in muscle fiber diameter (HP:0003557)2.24740533
6211 pairs of ribs (HP:0000878)2.24407014
63Macroorchidism (HP:0000053)2.24382557
64Abnormality of the Achilles tendon (HP:0005109)2.23934954
65Abnormality of macrophages (HP:0004311)2.22656484
66Maternal diabetes (HP:0009800)2.21178518
67Hyperlipoproteinemia (HP:0010980)2.20636148
68Missing ribs (HP:0000921)2.20317350
69Abnormal vertebral ossification (HP:0100569)2.20237873
70Arnold-Chiari malformation (HP:0002308)2.19358482
71Coronal craniosynostosis (HP:0004440)2.18875274
72Supernumerary bones of the axial skeleton (HP:0009144)2.18438532
73Hypochromic microcytic anemia (HP:0004840)2.18091962
74Rhabdomyolysis (HP:0003201)2.17892507
75Complement deficiency (HP:0004431)2.17828130
76Difficulty running (HP:0009046)2.14898908
77Recurrent abscess formation (HP:0002722)2.13939801
78Mitral valve prolapse (HP:0001634)2.13012328
79Abnormality of skeletal muscle fiber size (HP:0012084)2.11966506
80Conjunctival hamartoma (HP:0100780)2.09816073
81Neonatal hypoglycemia (HP:0001998)2.08384733
82Hypoglycemic coma (HP:0001325)2.07338350
83Absent septum pellucidum (HP:0001331)2.06242883
84Hepatocellular carcinoma (HP:0001402)2.05677346
85Abnormality of the phalanges of the hallux (HP:0010057)2.05370963
86Neurofibrillary tangles (HP:0002185)2.04378351
87Aortic aneurysm (HP:0004942)2.03876814
88Hydroxyprolinuria (HP:0003080)2.02806333
89Abnormality of proline metabolism (HP:0010907)2.02806333
90Recurrent bacterial skin infections (HP:0005406)2.02482285
91High anterior hairline (HP:0009890)2.01557722
92Hypoalphalipoproteinemia (HP:0003233)2.01250003
93Abnormality of the aortic arch (HP:0012303)1.99481937
94Lipoatrophy (HP:0100578)1.97328226
95Trigonocephaly (HP:0000243)1.97319019
96Abnormality of the distal phalanx of the thumb (HP:0009617)1.97077424
97Aortic dissection (HP:0002647)1.97038565
98Abnormality of incisor morphology (HP:0011063)1.97010507
99Macrocytic anemia (HP:0001972)1.96708428
100Abnormality of fatty-acid metabolism (HP:0004359)1.96400245
101Broad thumb (HP:0011304)1.95945614
102Achilles tendon contracture (HP:0001771)1.94980101
103Abnormal cartilage morphology (HP:0002763)1.94952794
104Hypobetalipoproteinemia (HP:0003563)1.94846991
105Vertebral clefting (HP:0008428)1.93115642
106Spinal rigidity (HP:0003306)1.92762620
107Rib fusion (HP:0000902)1.92001625
108Ketoacidosis (HP:0001993)1.91706371
109Cellulitis (HP:0100658)1.89572131
110Hyperglycinuria (HP:0003108)1.89494046
111Scapular winging (HP:0003691)1.88817661
112Cerebral inclusion bodies (HP:0100314)1.88328818
113Gastrointestinal infarctions (HP:0005244)1.87656744
114Hepatoblastoma (HP:0002884)1.86579413
115Disproportionate tall stature (HP:0001519)1.86394939
116Obsessive-compulsive behavior (HP:0000722)1.85516823
117Broad finger (HP:0001500)1.85390003
118Abnormal number of incisors (HP:0011064)1.85324447
119Vitreoretinal degeneration (HP:0000655)1.84679940
120Oligodactyly (HP:0012165)1.83771906
121Short 4th metacarpal (HP:0010044)1.83491179
122Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.83491179
123Prolonged partial thromboplastin time (HP:0003645)1.82879881
124Hyperglycinemia (HP:0002154)1.82713680
125Overgrowth (HP:0001548)1.81884667
126Elbow flexion contracture (HP:0002987)1.80468185
127Aqueductal stenosis (HP:0002410)1.80426766
128Hypolipoproteinemia (HP:0010981)1.80403072
129Abnormal pancreas size (HP:0012094)1.79716052
130Abnormality of glycine metabolism (HP:0010895)1.78750823
131Abnormality of serine family amino acid metabolism (HP:0010894)1.78750823
132Neonatal short-limb short stature (HP:0008921)1.77799553
133Calcaneovalgus deformity (HP:0001848)1.77705979
134Turricephaly (HP:0000262)1.77422821
135Blue sclerae (HP:0000592)1.77126976
136Hypercortisolism (HP:0001578)1.76075445
137Abnormality of complement system (HP:0005339)1.75972468
138Ulnar deviation of the wrist (HP:0003049)1.75785297
139Polycythemia (HP:0001901)1.74849076
140Impulsivity (HP:0100710)1.74658555
141Broad phalanges of the hand (HP:0009768)1.74504026
142Camptodactyly of toe (HP:0001836)1.74344518
143Multiple lipomas (HP:0001012)1.73900588
144Mitral regurgitation (HP:0001653)1.73861995
145Sleep apnea (HP:0010535)1.73646331
146Spontaneous hematomas (HP:0007420)1.73381459
147Hypogonadotrophic hypogonadism (HP:0000044)1.72718010
148Gingivitis (HP:0000230)1.71301587
149Venous abnormality (HP:0002624)1.71300617
150Oligodactyly (hands) (HP:0001180)1.71254286
151Deviation of the hallux (HP:0010051)1.71023402
152Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.70989915
153Buphthalmos (HP:0000557)1.70824023
154Abnormal finger flexion creases (HP:0006143)1.69750375
155Genu recurvatum (HP:0002816)1.69484850
156Asymmetric septal hypertrophy (HP:0001670)1.69108676
157Arterial tortuosity (HP:0005116)1.68265956
158Muscle stiffness (HP:0003552)1.68257777
159Supranuclear gaze palsy (HP:0000605)1.68253891
160Abnormality of the incisor (HP:0000676)1.68045708
161Renal duplication (HP:0000075)1.67960428
162Cerebral aneurysm (HP:0004944)1.67697069
163Sex reversal (HP:0012245)1.67509277
164Abnormal sex determination (HP:0012244)1.67509277
165Abnormality of the common coagulation pathway (HP:0010990)1.67258747
166Increased IgE level (HP:0003212)1.67026158
167Exostoses (HP:0100777)1.66926804
168Hemorrhage of the eye (HP:0011885)1.66305867
169Limb-girdle muscle atrophy (HP:0003797)1.65587690
170Pallor (HP:0000980)1.65041511
171Anosmia (HP:0000458)1.64265978
172Abnormality of the septum pellucidum (HP:0007375)1.64207701
173Abnormality of the intervertebral disk (HP:0005108)1.63959873
174Abnormal hair whorl (HP:0010721)1.63434381
175Broad palm (HP:0001169)1.63283779
176Asymmetric growth (HP:0100555)1.62578676
177Sporadic (HP:0003745)1.61703308
178Thoracic kyphosis (HP:0002942)1.61180055
179Abnormality of the calcaneus (HP:0008364)1.60594790
180Broad long bones (HP:0005622)1.59095302
181Abnormality of the fingertips (HP:0001211)1.57357241
182Broad phalanx (HP:0006009)1.56853759
183Amyloidosis (HP:0011034)1.56616766
184Orchitis (HP:0100796)1.56407199
185Truncal obesity (HP:0001956)1.55808592

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.61216975
2EPHB23.39444696
3TTN3.28821891
4PKN23.21724628
5PRPF4B2.77870649
6SIK12.45855053
7MAP3K92.25258642
8NEK92.21541931
9MAP3K102.19187424
10BCKDK2.14192268
11ERN12.13631427
12CDK192.06234008
13DMPK2.05418320
14PNCK2.04139441
15TYRO32.03739083
16MARK21.88681648
17KSR11.87698541
18KSR21.87338559
19MAP3K131.87238027
20LATS11.86285659
21PTK61.85294737
22ARAF1.82578191
23LRRK21.77882122
24PHKG21.73856217
25PHKG11.73856217
26TLK11.73114189
27OBSCN1.65613079
28PDGFRA1.65362542
29PRKD31.64380993
30CSK1.62314413
31RIPK41.60435124
32TGFBR21.43281164
33BRAF1.42946076
34ILK1.42522578
35INSRR1.41384121
36EPHA31.40833729
37RIPK11.39498029
38IRAK41.38493472
39NME21.38492503
40DDR21.36966149
41MYLK1.36061829
42FGFR41.35771722
43DYRK1B1.35621933
44RPS6KA41.33964922
45CDK61.31841427
46FLT31.30611808
47FGR1.29125397
48MAP2K31.27825608
49CASK1.26499505
50EPHB11.24840717
51SGK31.24567779
52BMX1.20902192
53WNK41.20039343
54LATS21.18604279
55PASK1.17967382
56MOS1.15241357
57SGK2231.14171942
58SGK4941.14171942
59NTRK21.13510426
60SGK21.13498226
61CAMK1G1.10145582
62PAK21.07588333
63MAP3K71.07179099
64TAOK11.06958998
65DYRK21.04895397
66WNK11.04334948
67MARK11.04156892
68PIK3CA1.03712701
69TGFBR11.03355909
70SIK21.03265628
71YES11.02271976
72DYRK31.01817571
73PIK3CG0.98455555
74NTRK10.96546059
75IRAK10.95027170
76PTK20.93971782
77MAP3K10.93437533
78MAP3K110.92880030
79SMG10.90778340
80KDR0.90541235
81STK110.90493056
82STK380.90042500
83FES0.89771500
84FGFR20.86518188
85FER0.84935428
86CAMK1D0.84429452
87TBK10.83401784
88PRKAA20.82884742
89TNIK0.82280321
90ERBB20.79702353
91STK30.79411187
92PRKD10.79387754
93PAK30.78045656
94RPS6KA20.76773814
95CDK120.74178476
96UHMK10.74063228
97PRKCZ0.71091959
98FGFR10.70760731
99MAP2K20.70626307
100MTOR0.67960089
101IRAK20.66576953
102MAPK110.66344627
103TIE10.66034411
104MAP3K20.65277315
105PRKD20.64590177
106FGFR30.63445788
107CDK90.63287444
108ALK0.62018293
109MET0.61417940
110PIM20.60937594
111DAPK30.60909957
112ABL20.60520271
113PDPK10.60441057
114GSK3A0.59473442
115ROCK10.59472200
116PAK40.58962620
117PRKCH0.58502357
118STK100.58131156
119CAMK40.55229223
120CAMKK10.53309659
121MAP3K60.52800359
122MST1R0.51288371
123ERBB30.49252642
124NTRK30.49039495
125HCK0.48715812
126MAP2K40.46395133
127MAP3K30.46258735
128CDK40.46249303
129ICK0.46055573
130CDC42BPA0.45350992
131SGK10.44528772
132CAMK10.44290911
133LIMK10.43531207
134TRPM70.43353170
135AKT20.43318113
136PDK10.43160726
137FYN0.42607405
138ROCK20.42465444
139PDGFRB0.41970490
140RPS6KA10.41960780
141MKNK20.41616674
142TNK20.41373323
143AKT10.41211479
144HIPK20.40819211
145ZAP700.40013344
146CDK11A0.39934483
147BTK0.39931923
148STK390.39137933
149MATK0.39105371
150BRD40.38924542
151EEF2K0.37624094
152STK240.36989260
153TAOK20.36858474
154RET0.36219938
155RPS6KA60.35965254
156STK40.35839720
157RPS6KC10.35531988
158RPS6KL10.35531988
159MKNK10.34586078
160JAK20.34581008
161FRK0.33233283
162ADRBK10.32272292

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.90561262
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.68210143
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.53156265
4Fatty acid degradation_Homo sapiens_hsa000712.52431277
5Nitrogen metabolism_Homo sapiens_hsa009102.51661150
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.45515353
7Propanoate metabolism_Homo sapiens_hsa006402.28033976
8Arginine biosynthesis_Homo sapiens_hsa002202.24441009
9Tryptophan metabolism_Homo sapiens_hsa003802.20291640
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.18317315
11B cell receptor signaling pathway_Homo sapiens_hsa046622.04634942
12Endometrial cancer_Homo sapiens_hsa052132.03194515
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.01004044
14Complement and coagulation cascades_Homo sapiens_hsa046101.99715959
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.96758138
16Non-small cell lung cancer_Homo sapiens_hsa052231.85126776
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83906268
18Butanoate metabolism_Homo sapiens_hsa006501.83319108
19PPAR signaling pathway_Homo sapiens_hsa033201.81403822
20Fatty acid metabolism_Homo sapiens_hsa012121.75846699
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.74949556
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.73797333
23VEGF signaling pathway_Homo sapiens_hsa043701.72008861
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69038438
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.69034981
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.65116329
27ErbB signaling pathway_Homo sapiens_hsa040121.64576840
28Axon guidance_Homo sapiens_hsa043601.62200590
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.62007000
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.55559073
31Colorectal cancer_Homo sapiens_hsa052101.54229392
32Peroxisome_Homo sapiens_hsa041461.53907951
33Osteoclast differentiation_Homo sapiens_hsa043801.51872965
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.51527457
35Chemical carcinogenesis_Homo sapiens_hsa052041.51101296
36beta-Alanine metabolism_Homo sapiens_hsa004101.50718496
37Dorso-ventral axis formation_Homo sapiens_hsa043201.50132668
38Lysine degradation_Homo sapiens_hsa003101.40417025
39Chemokine signaling pathway_Homo sapiens_hsa040621.38240411
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.37899317
41Starch and sucrose metabolism_Homo sapiens_hsa005001.35952331
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.34565619
43Sulfur relay system_Homo sapiens_hsa041221.31674340
44Staphylococcus aureus infection_Homo sapiens_hsa051501.30367348
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.29115915
46Phenylalanine metabolism_Homo sapiens_hsa003601.25983427
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25186548
48Histidine metabolism_Homo sapiens_hsa003401.24259572
49Tyrosine metabolism_Homo sapiens_hsa003501.22238770
50Long-term potentiation_Homo sapiens_hsa047201.20094592
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.18839675
52Leishmaniasis_Homo sapiens_hsa051401.18509983
53Gap junction_Homo sapiens_hsa045401.18508503
54Phospholipase D signaling pathway_Homo sapiens_hsa040721.17697371
55Glioma_Homo sapiens_hsa052141.16586194
56Rap1 signaling pathway_Homo sapiens_hsa040151.16400449
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.16203241
58GnRH signaling pathway_Homo sapiens_hsa049121.15282942
59Caffeine metabolism_Homo sapiens_hsa002321.14671534
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14316265
61Pyruvate metabolism_Homo sapiens_hsa006201.13671155
62Basal cell carcinoma_Homo sapiens_hsa052171.13593201
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12905038
64Melanogenesis_Homo sapiens_hsa049161.12611117
65Retinol metabolism_Homo sapiens_hsa008301.12112151
66Sulfur metabolism_Homo sapiens_hsa009201.10587346
67MAPK signaling pathway_Homo sapiens_hsa040101.10250794
68Prolactin signaling pathway_Homo sapiens_hsa049171.09585889
69Adherens junction_Homo sapiens_hsa045201.07873717
70Carbon metabolism_Homo sapiens_hsa012001.07470690
71Estrogen signaling pathway_Homo sapiens_hsa049151.07075454
72Dilated cardiomyopathy_Homo sapiens_hsa054141.03192998
73Fatty acid elongation_Homo sapiens_hsa000621.02631815
74Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01951123
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00252957
76Bladder cancer_Homo sapiens_hsa052191.00152324
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99791931
78Focal adhesion_Homo sapiens_hsa045100.98280660
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97822155
80ECM-receptor interaction_Homo sapiens_hsa045120.97288694
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96236336
82Choline metabolism in cancer_Homo sapiens_hsa052310.94426866
83Endocytosis_Homo sapiens_hsa041440.94376557
84Bile secretion_Homo sapiens_hsa049760.93987438
85Insulin resistance_Homo sapiens_hsa049310.92035963
86Long-term depression_Homo sapiens_hsa047300.91480238
87Proteoglycans in cancer_Homo sapiens_hsa052050.89971873
88Cholinergic synapse_Homo sapiens_hsa047250.87980630
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87574789
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.86716469
91T cell receptor signaling pathway_Homo sapiens_hsa046600.86290346
92Tuberculosis_Homo sapiens_hsa051520.85790346
93Ribosome_Homo sapiens_hsa030100.85671999
94Arginine and proline metabolism_Homo sapiens_hsa003300.85640138
95Ras signaling pathway_Homo sapiens_hsa040140.83846527
96Platelet activation_Homo sapiens_hsa046110.83282076
97Viral myocarditis_Homo sapiens_hsa054160.82608464
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.82523696
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80918047
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79711819
101Chronic myeloid leukemia_Homo sapiens_hsa052200.78656246
102Hepatitis B_Homo sapiens_hsa051610.77768029
103HIF-1 signaling pathway_Homo sapiens_hsa040660.77111264
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.76673280
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76271625
106Fat digestion and absorption_Homo sapiens_hsa049750.75567093
107Oxytocin signaling pathway_Homo sapiens_hsa049210.74650277
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74456706
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73475230
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72823557
111Phagosome_Homo sapiens_hsa041450.70427229
112Hippo signaling pathway_Homo sapiens_hsa043900.70103773
113AMPK signaling pathway_Homo sapiens_hsa041520.69265326
114Dopaminergic synapse_Homo sapiens_hsa047280.68468681
115Hepatitis C_Homo sapiens_hsa051600.67761207
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65536159
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.64707280
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64492294
119TGF-beta signaling pathway_Homo sapiens_hsa043500.64480651
120cAMP signaling pathway_Homo sapiens_hsa040240.64006897
121Small cell lung cancer_Homo sapiens_hsa052220.62870874
122Glutathione metabolism_Homo sapiens_hsa004800.62721897
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62581789
124Salmonella infection_Homo sapiens_hsa051320.62213341
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62135294
126Hedgehog signaling pathway_Homo sapiens_hsa043400.62128621
127Cardiac muscle contraction_Homo sapiens_hsa042600.62085496
128Prostate cancer_Homo sapiens_hsa052150.61490247
129Amoebiasis_Homo sapiens_hsa051460.61264688
130Shigellosis_Homo sapiens_hsa051310.60336680
131Inositol phosphate metabolism_Homo sapiens_hsa005620.60151337
132Influenza A_Homo sapiens_hsa051640.59398757
133Selenocompound metabolism_Homo sapiens_hsa004500.59315908
134Cocaine addiction_Homo sapiens_hsa050300.58081127
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57480790
136MicroRNAs in cancer_Homo sapiens_hsa052060.57443247
137AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56751993
138mTOR signaling pathway_Homo sapiens_hsa041500.56723769
139Renal cell carcinoma_Homo sapiens_hsa052110.55862521
140Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55391739
141Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54153927
142Parkinsons disease_Homo sapiens_hsa050120.53920943
143Insulin signaling pathway_Homo sapiens_hsa049100.53012324
144Folate biosynthesis_Homo sapiens_hsa007900.52905679
145Leukocyte transendothelial migration_Homo sapiens_hsa046700.51870925
146Melanoma_Homo sapiens_hsa052180.51450178
147Measles_Homo sapiens_hsa051620.51398326
148Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49786186
149Biosynthesis of amino acids_Homo sapiens_hsa012300.49250230
150Thyroid cancer_Homo sapiens_hsa052160.49115762
151Glucagon signaling pathway_Homo sapiens_hsa049220.44363503
152Acute myeloid leukemia_Homo sapiens_hsa052210.42641954
153Wnt signaling pathway_Homo sapiens_hsa043100.42566126
154Tight junction_Homo sapiens_hsa045300.42098076
155Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41796130
156PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38126245
157Notch signaling pathway_Homo sapiens_hsa043300.34283456
158Pancreatic cancer_Homo sapiens_hsa052120.34005802
159Malaria_Homo sapiens_hsa051440.33684443
160Pathways in cancer_Homo sapiens_hsa052000.32652328
161Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32577049
162Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32403618
163Alzheimers disease_Homo sapiens_hsa050100.31017208
164FoxO signaling pathway_Homo sapiens_hsa040680.30317769
165Prion diseases_Homo sapiens_hsa050200.29306273
166Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28484488

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