UBE2Q1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is 98% identical to the mouse counterpart. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.60253734
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.60253734
3histone H3-K36 demethylation (GO:0070544)4.81408684
4positive regulation of histone deacetylation (GO:0031065)4.10280052
5negative regulation of erythrocyte differentiation (GO:0045647)4.06760632
6regulation of NFAT protein import into nucleus (GO:0051532)4.01582242
7histone H3-K9 demethylation (GO:0033169)3.86108999
8Golgi transport vesicle coating (GO:0048200)3.66874479
9COPI coating of Golgi vesicle (GO:0048205)3.66874479
10protein localization to endosome (GO:0036010)3.63833513
11activation of Rac GTPase activity (GO:0032863)3.61855982
12heterochromatin organization (GO:0070828)3.47877717
13positive thymic T cell selection (GO:0045059)3.38402001
14pre-miRNA processing (GO:0031054)3.32336748
15RNA stabilization (GO:0043489)3.26250411
16mRNA stabilization (GO:0048255)3.26250411
17positive regulation of gamma-delta T cell activation (GO:0046645)3.25226431
18nuclear pore complex assembly (GO:0051292)3.20051339
19Arp2/3 complex-mediated actin nucleation (GO:0034314)3.13630605
20cellular protein complex localization (GO:0034629)3.11632598
21positive regulation of Cdc42 GTPase activity (GO:0043089)3.09309146
22mitotic chromosome condensation (GO:0007076)3.07569674
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.06290817
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.06290817
25retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.04352939
26regulation of gamma-delta T cell differentiation (GO:0045586)3.02685317
27regulation of translational fidelity (GO:0006450)3.01915318
28glucocorticoid receptor signaling pathway (GO:0042921)3.01603831
29focal adhesion assembly (GO:0048041)3.01199665
30cell-substrate adherens junction assembly (GO:0007045)3.01199665
31antigen processing and presentation of endogenous antigen (GO:0019883)3.00969213
32peptidyl-lysine dimethylation (GO:0018027)3.00205311
33regulation of ARF GTPase activity (GO:0032312)2.99590319
34maternal placenta development (GO:0001893)2.99497980
35adherens junction assembly (GO:0034333)2.99339520
36cytoplasmic mRNA processing body assembly (GO:0033962)2.99307614
37positive regulation of lamellipodium assembly (GO:0010592)2.94809691
38regulation of RNA export from nucleus (GO:0046831)2.94103175
39synaptonemal complex assembly (GO:0007130)2.93742414
40thymic T cell selection (GO:0045061)2.88470861
41B cell receptor signaling pathway (GO:0050853)2.87786758
42regulation of B cell receptor signaling pathway (GO:0050855)2.87430822
43positive regulation of protein deacetylation (GO:0090312)2.82516120
44NLS-bearing protein import into nucleus (GO:0006607)2.82450250
45cortical actin cytoskeleton organization (GO:0030866)2.80840140
46positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.78818515
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.75412695
48cell-substrate junction assembly (GO:0007044)2.74231161
49regulation of nucleobase-containing compound transport (GO:0032239)2.73892196
50protein export from nucleus (GO:0006611)2.73592270
51regulation of early endosome to late endosome transport (GO:2000641)2.71627182
523-UTR-mediated mRNA stabilization (GO:0070935)2.69841282
53positive T cell selection (GO:0043368)2.69507995
54regulation of interferon-beta biosynthetic process (GO:0045357)2.68258392
55positive regulation of receptor recycling (GO:0001921)2.68052261
56positive regulation by symbiont of host defense response (GO:0052509)2.66400308
57modulation by symbiont of host defense response (GO:0052031)2.66400308
58modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.66400308
59modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.66400308
60positive regulation by organism of defense response of other organism involved in symbiotic interact2.66400308
61modulation by symbiont of host immune response (GO:0052553)2.66400308
62regulation of glucose import in response to insulin stimulus (GO:2001273)2.64846227
63negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.63687460
64NIK/NF-kappaB signaling (GO:0038061)2.62680403
65regulation of mammary gland epithelial cell proliferation (GO:0033599)2.61482543
66regulation of chromatin binding (GO:0035561)2.61278930
67negative regulation of protein localization to plasma membrane (GO:1903077)2.60908562
68regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.59695793
69negative thymic T cell selection (GO:0045060)2.58422417
70regulation of gamma-delta T cell activation (GO:0046643)2.58359664
71receptor recycling (GO:0001881)2.57219789
72histone lysine demethylation (GO:0070076)2.56693606
73T cell selection (GO:0045058)2.56623744
74basement membrane organization (GO:0071711)2.56622616
75positive regulation of protein dephosphorylation (GO:0035307)2.56150969
76negative regulation of anoikis (GO:2000811)2.55125416
77positive regulation of Rap GTPase activity (GO:0032854)2.54655244
78body morphogenesis (GO:0010171)2.54545031
79adaptation of signaling pathway (GO:0023058)2.54479172
80maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.54239313
81negative regulation of histone methylation (GO:0031061)2.53936387
82modulation by symbiont of host cellular process (GO:0044068)2.53763412
83activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.52752564
84skin morphogenesis (GO:0043589)2.52367012
85barbed-end actin filament capping (GO:0051016)2.52317588
86protein retention in ER lumen (GO:0006621)2.52221317
87DNA synthesis involved in DNA repair (GO:0000731)2.52029809
88Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.51426594
89signal complex assembly (GO:0007172)2.50990579
90positive regulation of B cell differentiation (GO:0045579)2.50242936
91response to peptidoglycan (GO:0032494)2.49976855
92Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.49499207
93immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.49499207
94Fc-gamma receptor signaling pathway (GO:0038094)2.49499207
95cytoskeletal anchoring at plasma membrane (GO:0007016)2.49472216
96regulation of sister chromatid cohesion (GO:0007063)2.49320458
97corticosteroid receptor signaling pathway (GO:0031958)2.47964195
98histone demethylation (GO:0016577)2.47755816
99negative T cell selection (GO:0043383)2.47692318
100positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.47375850
101positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.46882071
102apoptotic process involved in morphogenesis (GO:0060561)2.46528953
103embryonic process involved in female pregnancy (GO:0060136)2.45092610
104regulation of histone H3-K27 methylation (GO:0061085)2.45083857
105antigen processing and presentation via MHC class Ib (GO:0002475)2.44347421
106response to laminar fluid shear stress (GO:0034616)2.44143290
107growth hormone receptor signaling pathway (GO:0060396)2.44022533
108histone H2B ubiquitination (GO:0033523)2.43506897
109alternative mRNA splicing, via spliceosome (GO:0000380)2.43476535
110pinocytosis (GO:0006907)2.42371982
111negative regulation of B cell proliferation (GO:0030889)2.42295321
112positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.42258897
113chromatin assembly (GO:0031497)2.42055512
114regulation of extracellular matrix disassembly (GO:0010715)2.41603157
115macrophage activation involved in immune response (GO:0002281)2.41468350
116hypotonic response (GO:0006971)2.39926880
117lipopolysaccharide-mediated signaling pathway (GO:0031663)2.38548247
118natural killer cell differentiation (GO:0001779)2.38373642
119regulation of clathrin-mediated endocytosis (GO:2000369)2.37235975
120positive regulation of lamellipodium organization (GO:1902745)2.36884073
121epithelial cell-cell adhesion (GO:0090136)2.36862502
122mannose metabolic process (GO:0006013)2.36434432
123actin nucleation (GO:0045010)2.36172367
124regulation of lipid kinase activity (GO:0043550)2.36027026
125response to nerve growth factor (GO:1990089)2.35719149
126cellular response to nerve growth factor stimulus (GO:1990090)2.35719149
127embryonic body morphogenesis (GO:0010172)2.35460451
128regulation of mRNA stability (GO:0043488)2.35420942
129negative regulation of RNA splicing (GO:0033119)2.35229829
130positive regulation of lipid kinase activity (GO:0090218)2.34900808
131glycosphingolipid catabolic process (GO:0046479)2.34588758
132negative regulation of fatty acid transport (GO:2000192)2.34114384
133synaptonemal complex organization (GO:0070193)2.33939009
134morphogenesis of an endothelium (GO:0003159)2.33929257
135endothelial tube morphogenesis (GO:0061154)2.33929257
136cortical cytoskeleton organization (GO:0030865)2.33077777
137negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.33058528
138protein complex localization (GO:0031503)2.31344919
139negative regulation of cell size (GO:0045792)2.31162891
140regulation of anoikis (GO:2000209)2.31123737
141JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.30690739
142peptidyl-threonine modification (GO:0018210)2.30546102
143pore complex assembly (GO:0046931)2.30152357
144activation of JUN kinase activity (GO:0007257)2.29446400
145regulation of T-helper 2 cell differentiation (GO:0045628)2.28025382
146chromosome organization involved in meiosis (GO:0070192)2.27577871
147stress fiber assembly (GO:0043149)2.26158473
148mitotic sister chromatid cohesion (GO:0007064)2.26156943
149regulation of interleukin-12 biosynthetic process (GO:0045075)2.26069221
150regulation of ARF protein signal transduction (GO:0032012)2.25920809
151germ cell migration (GO:0008354)2.25427074
152cellular extravasation (GO:0045123)2.24470894
153epithelial cell differentiation involved in prostate gland development (GO:0060742)2.24071953
154G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.23720607
155nuclear pore organization (GO:0006999)2.23637406
156mitotic G1 DNA damage checkpoint (GO:0031571)2.23543432
157regulation of B cell differentiation (GO:0045577)2.23159022
158vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.23055893
159peptidyl-threonine phosphorylation (GO:0018107)2.23055119
160regulation of leukocyte degranulation (GO:0043300)2.23019109
161receptor catabolic process (GO:0032801)2.22979647
162regulation of nuclease activity (GO:0032069)2.22937308
163leukocyte aggregation (GO:0070486)2.22689414
164vesicle coating (GO:0006901)2.22155082
165endoplasmic reticulum unfolded protein response (GO:0030968)2.21840052
166L-alpha-amino acid transmembrane transport (GO:1902475)2.21705165
167nerve growth factor signaling pathway (GO:0038180)2.21614917
168ER-nucleus signaling pathway (GO:0006984)2.21555162
169regulation of RNA stability (GO:0043487)2.21428322
170regulation of transcription from RNA polymerase I promoter (GO:0006356)2.21401797
171negative regulation of necroptotic process (GO:0060546)2.20940949
172regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.20367806
173positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.20367806
174spliceosomal tri-snRNP complex assembly (GO:0000244)2.19637846
175positive regulation of nuclease activity (GO:0032075)2.19520870

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human5.25118286
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.32260773
3MYC_22102868_ChIP-Seq_BL_Human3.96326406
4VDR_21846776_ChIP-Seq_THP-1_Human3.13854852
5E2F7_22180533_ChIP-Seq_HELA_Human3.02709367
6TCF7_22412390_ChIP-Seq_EML_Mouse2.87567366
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.82282441
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.75966263
9KDM2B_26808549_Chip-Seq_DND41_Human2.75303761
10KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.67106797
11* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.55419146
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.52981752
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.51658990
14* MAF_26560356_Chip-Seq_TH1_Human2.28150443
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.24912240
16* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.15646701
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.14631006
18UTX_26944678_Chip-Seq_JUKART_Human2.14531643
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11315433
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08968930
21ELK3_25401928_ChIP-Seq_HUVEC_Human2.07986846
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.02843239
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.02819915
24VDR_24763502_ChIP-Seq_THP-1_Human2.01567342
25RARG_19884340_ChIP-ChIP_MEFs_Mouse2.00463280
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.97304767
27KDM2B_26808549_Chip-Seq_JURKAT_Human1.90516522
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.86329256
29MYB_26560356_Chip-Seq_TH2_Human1.85878699
30LXR_22292898_ChIP-Seq_THP-1_Human1.85824870
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.83250073
32ZFP281_27345836_Chip-Seq_ESCs_Mouse1.82400557
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.79731758
34TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.73731240
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72695249
36MYB_26560356_Chip-Seq_TH1_Human1.72604722
37SPI1_23127762_ChIP-Seq_K562_Human1.71901988
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69278168
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68055666
40* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.67050217
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.66585118
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65170384
43* RUNX1_22412390_ChIP-Seq_EML_Mouse1.61414254
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59563068
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59237619
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.57467610
47EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.56356094
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54791458
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.54138382
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53971105
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.53118482
52KDM2B_26808549_Chip-Seq_K562_Human1.52320659
53KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.52170569
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.50652519
55RUNX_20019798_ChIP-Seq_JUKART_Human1.49952709
56SCL_19346495_ChIP-Seq_HPC-7_Human1.49049359
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.46786545
58TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.43913479
59NCOR1_26117541_ChIP-Seq_K562_Human1.43765322
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43647908
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42936542
62* RACK7_27058665_Chip-Seq_MCF-7_Human1.40773165
63CLOCK_20551151_ChIP-Seq_293T_Human1.40208105
64UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39809185
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38166470
66* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37834920
67* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.35559800
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35443731
69ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.34041705
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33779131
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31091595
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.30212587
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30174905
74MAF_26560356_Chip-Seq_TH2_Human1.29538256
75CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29193406
76SPI1_23547873_ChIP-Seq_NB4_Human1.27845374
77PKCTHETA_26484144_Chip-Seq_BREAST_Human1.26133846
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25232671
79* CREB1_26743006_Chip-Seq_LNCaP_Human1.22943899
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19343271
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19177276
82UBF1/2_26484160_Chip-Seq_HMECs_Human1.17508822
83* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16886887
84ATF3_27146783_Chip-Seq_COLON_Human1.16522500
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15803612
86PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15744625
87SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15521742
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15295347
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15170066
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14645138
91* TET1_21451524_ChIP-Seq_MESCs_Mouse1.14447938
92CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13763172
93* SMC4_20622854_ChIP-Seq_HELA_Human1.13754815
94SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13198324
95FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.12935015
96* TFEB_21752829_ChIP-Seq_HELA_Human1.12551320
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12391724
98IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12174614
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11568882
100ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11263968
101CHD1_26751641_Chip-Seq_LNCaP_Human1.10819897
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10760330
103PU_27001747_Chip-Seq_BMDM_Mouse1.10672580
104TP63_17297297_ChIP-ChIP_HaCaT_Human1.10584375
105SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09945921
106CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09593142
107GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.09384033
108* P68_20966046_ChIP-Seq_HELA_Human1.08677006
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08281075
110RUNX1_27514584_Chip-Seq_MCF-7_Human1.07315776
111NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06470091
112STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05874279
113IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05829533
114RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05484688
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03762759
116ZNF263_19887448_ChIP-Seq_K562_Human1.03346291
117HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02408803
118* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02177771
119GATA3_27048872_Chip-Seq_THYMUS_Human1.02083435
120GATA1_19941826_ChIP-Seq_K562_Human1.01961081
121NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01897537
122* SA1_27219007_Chip-Seq_ERYTHROID_Human1.00656603
123GATA6_25053715_ChIP-Seq_YYC3_Human1.00579114
124HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99809956
125SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99578712
126ERG_21242973_ChIP-ChIP_JURKAT_Human0.99240546
127PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99160956
128STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99023522
129* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98344780
130SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97531495
131SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96961233
132TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95696532
133POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94534527
134PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93727598
135CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93095872
136PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91945039
137AR_21909140_ChIP-Seq_LNCAP_Human0.91150308

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.20136147
2MP0003300_gastrointestinal_ulcer3.38077584
3MP0005076_abnormal_cell_differentiation3.26706960
4MP0010234_abnormal_vibrissa_follicle3.18816223
5MP0010352_gastrointestinal_tract_polyps3.17690707
6MP0005451_abnormal_body_composition3.02793849
7MP0003705_abnormal_hypodermis_morpholog3.01209228
8MP0005409_darkened_coat_color2.78678602
9MP0009278_abnormal_bone_marrow2.62712785
10MP0008961_abnormal_basal_metabolism2.45252524
11MP0003172_abnormal_lysosome_physiology2.34114899
12MP0002877_abnormal_melanocyte_morpholog2.26401783
13MP0003436_decreased_susceptibility_to2.21062029
14MP0000569_abnormal_digit_pigmentation2.16050098
15MP0010307_abnormal_tumor_latency2.13119465
16MP0001835_abnormal_antigen_presentation2.11813387
17MP0005058_abnormal_lysosome_morphology2.09839601
18MP0004233_abnormal_muscle_weight2.03120311
19MP0008260_abnormal_autophagy2.03038162
20MP0002796_impaired_skin_barrier2.00364515
21MP0003191_abnormal_cellular_cholesterol1.99532914
22MP0000685_abnormal_immune_system1.96653881
23MP0001800_abnormal_humoral_immune1.95650964
24MP0002166_altered_tumor_susceptibility1.95139611
25MP0001790_abnormal_immune_system1.76537011
26MP0005387_immune_system_phenotype1.76537011
27MP0002452_abnormal_antigen_presenting1.75425239
28MP0003566_abnormal_cell_adhesion1.74893151
29MP0008438_abnormal_cutaneous_collagen1.73141324
30MP0005000_abnormal_immune_tolerance1.69852103
31MP0004808_abnormal_hematopoietic_stem1.65180674
32MP0004510_myositis1.60266142
33MP0002398_abnormal_bone_marrow1.59523480
34MP0002420_abnormal_adaptive_immunity1.56712507
35MP0001819_abnormal_immune_cell1.55746493
36MP0000678_abnormal_parathyroid_gland1.54929927
37MP0002723_abnormal_immune_serum1.54625214
38MP0004858_abnormal_nervous_system1.50893822
39MP0002006_tumorigenesis1.48071104
40MP0002405_respiratory_system_inflammati1.45135061
41MP0003045_fibrosis1.44554222
42MP0005501_abnormal_skin_physiology1.44377679
43MP0004947_skin_inflammation1.42674167
44MP0005167_abnormal_blood-brain_barrier1.42388743
45MP0005464_abnormal_platelet_physiology1.41419757
46MP0003866_abnormal_defecation1.40991113
47MP0005025_abnormal_response_to1.38920072
48MP0000703_abnormal_thymus_morphology1.37527767
49MP0003448_altered_tumor_morphology1.36911794
50MP0000716_abnormal_immune_system1.35727510
51MP0002419_abnormal_innate_immunity1.35372799
52MP0005174_abnormal_tail_pigmentation1.33989728
53MP0006082_CNS_inflammation1.32716020
54MP0002060_abnormal_skin_morphology1.30172728
55MP0005666_abnormal_adipose_tissue1.29508193
56MP0010155_abnormal_intestine_physiology1.29136964
57MP0002722_abnormal_immune_system1.26760786
58MP0000689_abnormal_spleen_morphology1.26402291
59MP0009333_abnormal_splenocyte_physiolog1.25485482
60MP0002089_abnormal_postnatal_growth/wei1.25090393
61MP0004185_abnormal_adipocyte_glucose1.21798568
62MP0005310_abnormal_salivary_gland1.20425532
63MP0005671_abnormal_response_to1.17030822
64MP0003763_abnormal_thymus_physiology1.16003791
65MP0001216_abnormal_epidermal_layer1.15061704
66MP0000858_altered_metastatic_potential1.14227393
67MP0003453_abnormal_keratinocyte_physiol1.14181688
68MP0002429_abnormal_blood_cell1.14105294
69MP0002909_abnormal_adrenal_gland1.13811143
70MP0009840_abnormal_foam_cell1.12392327
71MP0000490_abnormal_crypts_of1.10998197
72MP0000733_abnormal_muscle_development1.09205695
73MP0002086_abnormal_extraembryonic_tissu1.08789623
74MP0005623_abnormal_meninges_morphology1.08112315
75MP0005023_abnormal_wound_healing1.07757483
76MP0001545_abnormal_hematopoietic_system1.06857923
77MP0005397_hematopoietic_system_phenotyp1.06857923
78MP0003828_pulmonary_edema1.06749560
79MP0005621_abnormal_cell_physiology1.05290523
80MP0001845_abnormal_inflammatory_respons1.04063072
81MP0000604_amyloidosis1.03164103
82MP0003693_abnormal_embryo_hatching1.02287097
83MP0004197_abnormal_fetal_growth/weight/1.01647351
84MP0003091_abnormal_cell_migration1.00949084
85MP0003075_altered_response_to1.00627038
86MP0004381_abnormal_hair_follicle0.99960824
87MP0009672_abnormal_birth_weight0.99704579
88MP0003123_paternal_imprinting0.99468023
89MP0001958_emphysema0.99295150
90MP0005257_abnormal_intraocular_pressure0.97273690
91MP0003329_amyloid_beta_deposits0.96963779
92MP0000371_diluted_coat_color0.96367516
93MP0002148_abnormal_hypersensitivity_rea0.95875639
94MP0003941_abnormal_skin_development0.94910255
95MP0001730_embryonic_growth_arrest0.94439874
96MP0008770_decreased_survivor_rate0.94295589
97MP0002998_abnormal_bone_remodeling0.93630384
98MP0001849_ear_inflammation0.93601350
99MP0002396_abnormal_hematopoietic_system0.93343611
100MP0002009_preneoplasia0.93237669
101MP0006054_spinal_hemorrhage0.93000070
102MP0003183_abnormal_peptide_metabolism0.92266361
103MP0000465_gastrointestinal_hemorrhage0.92078552
104MP0001533_abnormal_skeleton_physiology0.91483328
105MP0003283_abnormal_digestive_organ0.90803350
106MP0005166_decreased_susceptibility_to0.89972597
107MP0001915_intracranial_hemorrhage0.88391254
108MP0002084_abnormal_developmental_patter0.88370222
109MP0000003_abnormal_adipose_tissue0.88195531
110MP0003115_abnormal_respiratory_system0.87249586
111MP0001853_heart_inflammation0.86347826
112MP0001348_abnormal_lacrimal_gland0.84480230
113MP0001851_eye_inflammation0.80023512
114MP0004264_abnormal_extraembryonic_tissu0.79943792
115MP0010678_abnormal_skin_adnexa0.79771387
116MP0000350_abnormal_cell_proliferation0.77498293
117MP0008057_abnormal_DNA_replication0.77473213
118MP0000313_abnormal_cell_death0.76783364
119MP0000477_abnormal_intestine_morphology0.76175779
120MP0000767_abnormal_smooth_muscle0.75972594
121MP0004859_abnormal_synaptic_plasticity0.75655307
122MP0003111_abnormal_nucleus_morphology0.75279851
123MP0001873_stomach_inflammation0.75008937
124MP0002925_abnormal_cardiovascular_devel0.73536981
125MP0002019_abnormal_tumor_incidence0.73415713
126MP0008004_abnormal_stomach_pH0.73008104
127MP0009053_abnormal_anal_canal0.73005827
128MP0001697_abnormal_embryo_size0.72847367
129MP0002971_abnormal_brown_adipose0.72789693
130MP0009931_abnormal_skin_appearance0.72181415
131MP0003984_embryonic_growth_retardation0.71903495
132MP0000377_abnormal_hair_follicle0.71544989
133MP0002080_prenatal_lethality0.71433252
134MP0009703_decreased_birth_body0.71095042
135MP0005384_cellular_phenotype0.70905027
136MP0004272_abnormal_basement_membrane0.70117567
137MP0005375_adipose_tissue_phenotype0.67406496
138MP0004957_abnormal_blastocyst_morpholog0.67165681
139MP0000013_abnormal_adipose_tissue0.66117871
140MP0001672_abnormal_embryogenesis/_devel0.65427229

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.60428587
2Cerebral aneurysm (HP:0004944)3.18631693
3Hyperparathyroidism (HP:0000843)2.99143375
4Subacute progressive viral hepatitis (HP:0006572)2.98648805
5Vertebral compression fractures (HP:0002953)2.87217429
6Volvulus (HP:0002580)2.78262830
7Hematochezia (HP:0002573)2.77995364
8Disinhibition (HP:0000734)2.73251523
9Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.65388453
10Cellulitis (HP:0100658)2.63940535
11Recurrent abscess formation (HP:0002722)2.62688172
12Macroorchidism (HP:0000053)2.60161338
13Protrusio acetabuli (HP:0003179)2.58090983
14Recurrent bacterial skin infections (HP:0005406)2.55351634
15Recurrent fungal infections (HP:0002841)2.50086607
16Premature rupture of membranes (HP:0001788)2.44806980
17Colitis (HP:0002583)2.43277576
18Short nail (HP:0001799)2.42631872
19Upper motor neuron abnormality (HP:0002127)2.40595421
20Increased cerebral lipofuscin (HP:0011813)2.38781709
21Papilledema (HP:0001085)2.38748578
22Apathy (HP:0000741)2.38664510
23Diminished motivation (HP:0000745)2.38389719
24Pustule (HP:0200039)2.34304055
25Recurrent viral infections (HP:0004429)2.33789103
26Dysostosis multiplex (HP:0000943)2.29065570
27Viral hepatitis (HP:0006562)2.28971088
28Metaphyseal cupping (HP:0003021)2.26442417
29Hand muscle atrophy (HP:0009130)2.22676318
30Abnormality of the thoracic spine (HP:0100711)2.21877916
31Interstitial pulmonary disease (HP:0006530)2.21144185
32Abnormality of the fingertips (HP:0001211)2.19918570
33Urinary glycosaminoglycan excretion (HP:0003541)2.19587385
34Mucopolysacchariduria (HP:0008155)2.19587385
35Hyperacusis (HP:0010780)2.17271574
36Ulnar bowing (HP:0003031)2.15651199
37Deep venous thrombosis (HP:0002625)2.14333213
38Gastrointestinal inflammation (HP:0004386)2.14194666
39Distal lower limb amyotrophy (HP:0008944)2.13973679
40Ankyloglossia (HP:0010296)2.13267716
41Obstructive sleep apnea (HP:0002870)2.13088648
42Flat acetabular roof (HP:0003180)2.10830671
43Upper limb amyotrophy (HP:0009129)2.07432405
44Distal upper limb amyotrophy (HP:0007149)2.07432405
45Cerebral inclusion bodies (HP:0100314)2.06425095
46Abnormality of oral frenula (HP:0000190)2.06331131
47Inflammation of the large intestine (HP:0002037)2.06264673
48Deep palmar crease (HP:0006191)2.05547231
49Thrombocytosis (HP:0001894)2.05268983
50Papilloma (HP:0012740)2.02188099
51Verrucae (HP:0200043)2.02188099
52Bone pain (HP:0002653)2.02122197
53Abnormality of macrophages (HP:0004311)2.02023317
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.01721992
55Osteolytic defects of the hand bones (HP:0009699)2.01721992
56Nasal polyposis (HP:0100582)2.01332317
57Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.01237421
58Increased density of long bones (HP:0006392)2.00945597
59Resting tremor (HP:0002322)2.00220072
60Termporal pattern (HP:0011008)1.99855015
61Insidious onset (HP:0003587)1.99855015
62Thoracic kyphosis (HP:0002942)1.98641051
63Long palpebral fissure (HP:0000637)1.98563567
64Loss of speech (HP:0002371)1.97626788
65Abnormality of glycolipid metabolism (HP:0010969)1.96248209
66Abnormality of liposaccharide metabolism (HP:0010968)1.96248209
67Abnormality of glycosphingolipid metabolism (HP:0004343)1.96248209
68Rectal prolapse (HP:0002035)1.95407598
69Spinal cord lesions (HP:0100561)1.94582989
70Syringomyelia (HP:0003396)1.94582989
71Chronic obstructive pulmonary disease (HP:0006510)1.93539113
72Obstructive lung disease (HP:0006536)1.93539113
73Basal cell carcinoma (HP:0002671)1.92855167
74Neurofibrillary tangles (HP:0002185)1.92730271
75Inappropriate behavior (HP:0000719)1.92616936
76Thin bony cortex (HP:0002753)1.91910568
77Mitral valve prolapse (HP:0001634)1.91827566
78Striae distensae (HP:0001065)1.89236357
79Achilles tendon contracture (HP:0001771)1.89007208
80Abnormal delayed hypersensitivity skin test (HP:0002963)1.86391278
81Mitral regurgitation (HP:0001653)1.85118479
82Abnormality of the nasal mucosa (HP:0000433)1.84835870
83Autoimmune thrombocytopenia (HP:0001973)1.84071753
84Dilatation of the ascending aorta (HP:0005111)1.83573541
85Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83560737
86Abnormality of polysaccharide metabolism (HP:0011012)1.83560737
87Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83560737
88Genu recurvatum (HP:0002816)1.82234022
89Hypercortisolism (HP:0001578)1.81909049
90Deep philtrum (HP:0002002)1.81623258
91Increased neuronal autofluorescent lipopigment (HP:0002074)1.81351601
92Cutaneous melanoma (HP:0012056)1.79737732
93Recurrent gram-negative bacterial infections (HP:0005420)1.79734484
94Mediastinal lymphadenopathy (HP:0100721)1.79595709
95Fragile skin (HP:0001030)1.78984944
96Gastrointestinal carcinoma (HP:0002672)1.78354249
97Malignant gastrointestinal tract tumors (HP:0006749)1.78354249
98Heterotopia (HP:0002282)1.77734551
99Amyotrophic lateral sclerosis (HP:0007354)1.77451461
100Slow saccadic eye movements (HP:0000514)1.77429670
101Increased connective tissue (HP:0009025)1.76922516
102Global brain atrophy (HP:0002283)1.76827041
103Progressive external ophthalmoplegia (HP:0000590)1.75758965
104Arterial tortuosity (HP:0005116)1.75724194
105Supranuclear gaze palsy (HP:0000605)1.75660747
106Bladder neoplasm (HP:0009725)1.75650818
107Bladder carcinoma (HP:0002862)1.75650818
108Chest pain (HP:0100749)1.75209133
109Somatic mutation (HP:0001428)1.74658856
110Distal lower limb muscle weakness (HP:0009053)1.74281889
111Aneurysm (HP:0002617)1.74123239
112Transitional cell carcinoma of the bladder (HP:0006740)1.73903487
113J-shaped sella turcica (HP:0002680)1.73510895
114Broad face (HP:0000283)1.73509578
115Polycythemia (HP:0001901)1.72811058
116Enlarged penis (HP:0000040)1.71914635
117Abnormality of the distal phalanges of the toes (HP:0010182)1.71114952
118Spontaneous hematomas (HP:0007420)1.70987134
119Uterine leiomyosarcoma (HP:0002891)1.70730401
120Leiomyosarcoma (HP:0100243)1.70730401
121Fatigue (HP:0012378)1.69662985
122Renal cell carcinoma (HP:0005584)1.69650238
123Sparse lateral eyebrow (HP:0005338)1.69545663
124Persistence of primary teeth (HP:0006335)1.69505531
125Purpura (HP:0000979)1.69478921
126Multiple lipomas (HP:0001012)1.69312569
127Increased CSF protein (HP:0002922)1.69117489
128Abnormality of the Achilles tendon (HP:0005109)1.68398721
129T lymphocytopenia (HP:0005403)1.67864918
130Elbow flexion contracture (HP:0002987)1.67806110
131Myocardial infarction (HP:0001658)1.67726659
132Insomnia (HP:0100785)1.67633088
133Recurrent bronchitis (HP:0002837)1.67339895
134Emphysema (HP:0002097)1.66439140
135Segmental peripheral demyelination/remyelination (HP:0003481)1.66129799
136Disproportionate tall stature (HP:0001519)1.65995529
137Gastrointestinal stroma tumor (HP:0100723)1.65580627
138Chronic otitis media (HP:0000389)1.65500070
139Neuronal loss in central nervous system (HP:0002529)1.65215296
140Centrally nucleated skeletal muscle fibers (HP:0003687)1.65103663
141Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.65075407
142Recurrent skin infections (HP:0001581)1.64827042
143Bicuspid aortic valve (HP:0001647)1.64377982
144Blue sclerae (HP:0000592)1.63891129
145Micronodular cirrhosis (HP:0001413)1.63816101
146Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.63105758
147Shallow orbits (HP:0000586)1.63023858
148Arterial thrombosis (HP:0004420)1.62516576
149Recurrent cutaneous fungal infections (HP:0011370)1.62455036
150Chronic mucocutaneous candidiasis (HP:0002728)1.62455036
151Pathologic fracture (HP:0002756)1.62391758
152Vertebral arch anomaly (HP:0008438)1.62207455
153Vascular tortuosity (HP:0004948)1.62090038
154Gingivitis (HP:0000230)1.61892008
155Prominent nose (HP:0000448)1.61338519
156Fibrous tissue neoplasm (HP:0012316)1.61319182
157Asymmetry of the thorax (HP:0001555)1.60708799
158Pointed chin (HP:0000307)1.59638989
159Myositis (HP:0100614)1.58894485
160Axonal loss (HP:0003447)1.58556140
161Bulbar palsy (HP:0001283)1.58459551
162Increased variability in muscle fiber diameter (HP:0003557)1.57253699
163Abnormality of the lumbar spine (HP:0100712)1.56713445
164Trismus (HP:0000211)1.56668500
165Broad distal phalanx of finger (HP:0009836)1.55591833
166Abnormality of skeletal muscle fiber size (HP:0012084)1.55481453
167Mitral stenosis (HP:0001718)1.55057257
168Back pain (HP:0003418)1.54979946
169Polygenic inheritance (HP:0010982)1.54565994
170Menstrual irregularities (HP:0000858)1.54551846

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.97420066
2TRIB33.85713021
3PKN23.43162973
4MAP3K102.90651451
5MAP4K12.62596952
6SMG12.56468397
7SIK22.45631005
8CDK122.36275236
9IRAK32.35306681
10EEF2K2.25335143
11GRK62.15904022
12MET2.14092478
13ALK2.13487079
14ERN12.05699139
15SCYL22.03991240
16PTK61.91577605
17RIPK41.84276650
18BMX1.73344812
19STK101.69161386
20LRRK21.69003777
21TYRO31.63417630
22NME21.62830751
23TAOK21.60204660
24MAP3K91.54165530
25CAMK1G1.51302432
26RIPK11.50367674
27MST1R1.48355267
28PDGFRA1.47488202
29CDK61.46587347
30ARAF1.38056665
31ZAP701.36955071
32LATS21.36611972
33BLK1.36303341
34FES1.36233913
35KSR21.35525074
36CSK1.33565959
37ICK1.23183057
38FGR1.22906951
39NEK21.18885501
40CAMK1D1.18380402
41MAP3K31.18116578
42TYK21.16758102
43MAP3K141.16717902
44MAP3K61.10739122
45IRAK21.09654209
46DMPK1.08374167
47RET1.05512409
48CAMKK11.05120993
49HIPK21.03069863
50HCK1.02006256
51NEK90.97668281
52MAP3K20.92997235
53PDGFRB0.92304322
54PAK40.92129714
55FGFR30.92122903
56EPHB10.90608841
57SYK0.89106478
58TGFBR20.88283089
59PASK0.88070428
60YES10.87656158
61JAK20.86950112
62EPHA20.86647411
63JAK10.84556102
64MARK20.84406610
65ITK0.83260547
66TAOK10.82398754
67JAK30.80695638
68MAP3K110.80067539
69NTRK10.79520760
70TBK10.77252811
71CDC42BPA0.76275830
72TTN0.75326495
73PRKCH0.74950770
74MTOR0.74913067
75MAP3K80.74386573
76STK110.73805267
77PRKD30.73202440
78EGFR0.72946517
79BTK0.72493958
80LCK0.72195166
81PRKD20.71952199
82MAP3K130.71387864
83CSF1R0.71275386
84BRAF0.70489905
85MOS0.70353009
86DDR20.69293391
87RPS6KA20.68290056
88CDK70.67953316
89PTK2B0.67226501
90TNK20.65218906
91PTK20.64122451
92MAP3K10.64001768
93RPS6KL10.63877497
94RPS6KC10.63877497
95PDK10.63563147
96KSR10.63363752
97STK240.62168187
98PNCK0.61634853
99FGFR40.60695350
100CDK40.59888478
101STK30.59622604
102PIM10.58968596
103MARK30.57369852
104RPS6KA60.55866456
105RPS6KB20.55632863
106MATK0.55073297
107BRD40.55018166
108PAK20.54839707
109CDK90.52772926
110ILK0.51444114
111DYRK1B0.51216342
112RPS6KA40.50500820
113MAP2K30.50022893
114UHMK10.49984531
115CDC70.48298981
116STK380.48267327
117TESK10.47859239
118IRAK40.47226631
119SGK30.45347960
120SIK30.44440643
121SIK10.44112640
122RPS6KA10.43981244
123GSK3A0.42950866
124DAPK10.41547107
125INSR0.41289465
126LATS10.41233105
127MAPK110.41013066
128FYN0.40980878
129TAOK30.40781540
130MAP3K50.40729385
131PIM20.40275192
132CDK190.40246320
133PDPK10.37211379
134WNK10.36608630
135RAF10.35030456

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.23834559
2B cell receptor signaling pathway_Homo sapiens_hsa046622.13835031
3Osteoclast differentiation_Homo sapiens_hsa043801.87111991
4Chronic myeloid leukemia_Homo sapiens_hsa052201.77379021
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.73324177
6Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.72467021
7mTOR signaling pathway_Homo sapiens_hsa041501.71127954
8Leishmaniasis_Homo sapiens_hsa051401.63892505
9Prion diseases_Homo sapiens_hsa050201.58281536
10VEGF signaling pathway_Homo sapiens_hsa043701.53925673
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.53715717
12Neurotrophin signaling pathway_Homo sapiens_hsa047221.50464082
13Antigen processing and presentation_Homo sapiens_hsa046121.48359826
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.42478844
15Glioma_Homo sapiens_hsa052141.39394526
16T cell receptor signaling pathway_Homo sapiens_hsa046601.38944785
17Non-small cell lung cancer_Homo sapiens_hsa052231.38580796
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34665610
19Estrogen signaling pathway_Homo sapiens_hsa049151.33931381
20Dorso-ventral axis formation_Homo sapiens_hsa043201.31191573
21Acute myeloid leukemia_Homo sapiens_hsa052211.30407916
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.29580972
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28349137
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27228280
25Tuberculosis_Homo sapiens_hsa051521.24509460
26Long-term potentiation_Homo sapiens_hsa047201.23812056
27Pancreatic cancer_Homo sapiens_hsa052121.20664066
28Colorectal cancer_Homo sapiens_hsa052101.18168079
29Chemokine signaling pathway_Homo sapiens_hsa040621.17830816
30Toxoplasmosis_Homo sapiens_hsa051451.17438603
31Primary immunodeficiency_Homo sapiens_hsa053401.17375853
32Proteoglycans in cancer_Homo sapiens_hsa052051.16853914
33Hepatitis C_Homo sapiens_hsa051601.16614662
34Endometrial cancer_Homo sapiens_hsa052131.15500442
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14215688
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.14119626
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.13974408
38Renal cell carcinoma_Homo sapiens_hsa052111.12144085
39Shigellosis_Homo sapiens_hsa051311.11466636
40Platelet activation_Homo sapiens_hsa046111.11177871
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09267123
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09252298
43Hepatitis B_Homo sapiens_hsa051611.02578784
44Lysosome_Homo sapiens_hsa041421.01080622
45Nitrogen metabolism_Homo sapiens_hsa009100.99472407
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98871245
47Adherens junction_Homo sapiens_hsa045200.97279942
48Type II diabetes mellitus_Homo sapiens_hsa049300.97038834
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.95898703
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.94487064
51MicroRNAs in cancer_Homo sapiens_hsa052060.93089663
52Pentose phosphate pathway_Homo sapiens_hsa000300.93028787
53Salmonella infection_Homo sapiens_hsa051320.92614681
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92123701
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.91151462
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91054134
57Pertussis_Homo sapiens_hsa051330.89009262
58Endocytosis_Homo sapiens_hsa041440.88357132
59GnRH signaling pathway_Homo sapiens_hsa049120.87893489
60Amoebiasis_Homo sapiens_hsa051460.87481999
61Focal adhesion_Homo sapiens_hsa045100.85390640
62Small cell lung cancer_Homo sapiens_hsa052220.84805771
63Apoptosis_Homo sapiens_hsa042100.84464728
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84375790
65Prolactin signaling pathway_Homo sapiens_hsa049170.83888535
66TNF signaling pathway_Homo sapiens_hsa046680.83406599
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83226136
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82436557
69ErbB signaling pathway_Homo sapiens_hsa040120.82288459
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.81578153
71Prostate cancer_Homo sapiens_hsa052150.80837187
72Viral myocarditis_Homo sapiens_hsa054160.80711683
73Herpes simplex infection_Homo sapiens_hsa051680.80672741
74Viral carcinogenesis_Homo sapiens_hsa052030.79055049
75Bladder cancer_Homo sapiens_hsa052190.78987514
76Insulin resistance_Homo sapiens_hsa049310.78717588
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78500432
78MAPK signaling pathway_Homo sapiens_hsa040100.77992960
79AMPK signaling pathway_Homo sapiens_hsa041520.77886289
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.77328489
81Measles_Homo sapiens_hsa051620.76693348
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.75961002
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74727274
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74310272
85Choline metabolism in cancer_Homo sapiens_hsa052310.74286930
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73228877
87Long-term depression_Homo sapiens_hsa047300.72647390
88Renin secretion_Homo sapiens_hsa049240.71853536
89Vibrio cholerae infection_Homo sapiens_hsa051100.71706582
90Notch signaling pathway_Homo sapiens_hsa043300.71473350
91HTLV-I infection_Homo sapiens_hsa051660.70845391
92Dopaminergic synapse_Homo sapiens_hsa047280.69324626
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69191242
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68387921
95Thyroid cancer_Homo sapiens_hsa052160.67902812
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67851664
97Gastric acid secretion_Homo sapiens_hsa049710.67689828
98Rap1 signaling pathway_Homo sapiens_hsa040150.66485820
99FoxO signaling pathway_Homo sapiens_hsa040680.65420274
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64678229
101Inositol phosphate metabolism_Homo sapiens_hsa005620.63133906
102Influenza A_Homo sapiens_hsa051640.62810192
103Epstein-Barr virus infection_Homo sapiens_hsa051690.62559744
104mRNA surveillance pathway_Homo sapiens_hsa030150.62207757
105Melanogenesis_Homo sapiens_hsa049160.62018107
106N-Glycan biosynthesis_Homo sapiens_hsa005100.61826454
107Gap junction_Homo sapiens_hsa045400.61805010
108Oxytocin signaling pathway_Homo sapiens_hsa049210.59484261
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59380164
110HIF-1 signaling pathway_Homo sapiens_hsa040660.58915847
111Malaria_Homo sapiens_hsa051440.57994195
112Galactose metabolism_Homo sapiens_hsa000520.57758908
113Legionellosis_Homo sapiens_hsa051340.57277020
114Insulin signaling pathway_Homo sapiens_hsa049100.56992364
115Pathways in cancer_Homo sapiens_hsa052000.56826637
116Staphylococcus aureus infection_Homo sapiens_hsa051500.56402897
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55084771
118Cell cycle_Homo sapiens_hsa041100.54145527
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.54121442
120Melanoma_Homo sapiens_hsa052180.53513101
121Phagosome_Homo sapiens_hsa041450.53505431
122Sphingolipid metabolism_Homo sapiens_hsa006000.50760762
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50457011

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