UBE2N

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cullin deneddylation (GO:0010388)5.10588808
2protein deneddylation (GO:0000338)4.70961657
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.37350562
4* DNA double-strand break processing (GO:0000729)4.30599561
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.23918306
6negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.95320296
7establishment of integrated proviral latency (GO:0075713)3.82514665
8synaptic vesicle docking involved in exocytosis (GO:0016081)3.80272041
9positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.79576306
10regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.76505551
11energy coupled proton transport, down electrochemical gradient (GO:0015985)3.75720457
12ATP synthesis coupled proton transport (GO:0015986)3.75720457
13anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.75343550
14exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.72736065
15nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.69794026
16deoxyribonucleotide biosynthetic process (GO:0009263)3.61778323
172-deoxyribonucleotide biosynthetic process (GO:0009265)3.57186044
18deoxyribose phosphate biosynthetic process (GO:0046385)3.57186044
19negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.55186753
20negative regulation of ligase activity (GO:0051352)3.55186753
21replication fork processing (GO:0031297)3.54517724
22rRNA modification (GO:0000154)3.54027397
23ribosome assembly (GO:0042255)3.52387827
24* DNA catabolic process, exonucleolytic (GO:0000738)3.44868681
25DNA damage response, detection of DNA damage (GO:0042769)3.44805876
26IMP biosynthetic process (GO:0006188)3.35591054
27* positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.33991206
28regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.33804310
29regulation of mitotic spindle checkpoint (GO:1903504)3.33804310
30negative regulation of DNA-dependent DNA replication (GO:2000104)3.33475345
31mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.31147272
32DNA replication checkpoint (GO:0000076)3.28427260
33respiratory chain complex IV assembly (GO:0008535)3.28274221
34protein localization to kinetochore (GO:0034501)3.25625755
35proteasome assembly (GO:0043248)3.23331322
36DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.23115572
37protein complex biogenesis (GO:0070271)3.22498142
38histone mRNA metabolic process (GO:0008334)3.22486845
39mitochondrial respiratory chain complex assembly (GO:0033108)3.22183768
40pseudouridine synthesis (GO:0001522)3.21396370
41rRNA methylation (GO:0031167)3.20156643
42regulation of cellular amino acid metabolic process (GO:0006521)3.19020979
43purine nucleobase biosynthetic process (GO:0009113)3.18968063
44DNA strand elongation involved in DNA replication (GO:0006271)3.18025087
45signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.15983402
46intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.15983402
47spliceosomal snRNP assembly (GO:0000387)3.12805522
48viral mRNA export from host cell nucleus (GO:0046784)3.12748032
49* positive regulation of ligase activity (GO:0051351)3.11832707
50signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.11642376
51signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.11642376
52signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.11642376
53somatic diversification of immune receptors via somatic mutation (GO:0002566)3.09775761
54somatic hypermutation of immunoglobulin genes (GO:0016446)3.09775761
55nucleobase biosynthetic process (GO:0046112)3.09311792
56negative regulation of DNA recombination (GO:0045910)3.09102459
57formation of translation preinitiation complex (GO:0001731)3.06820653
58NADH dehydrogenase complex assembly (GO:0010257)3.05695593
59mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.05695593
60mitochondrial respiratory chain complex I assembly (GO:0032981)3.05695593
61maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.05554234
62peptidyl-arginine omega-N-methylation (GO:0035247)3.05447854
63synaptic vesicle exocytosis (GO:0016079)3.04924318
64mitotic metaphase plate congression (GO:0007080)3.04662241
65de novo protein folding (GO:0006458)3.02983018
66signal transduction involved in DNA integrity checkpoint (GO:0072401)3.02713472
67signal transduction involved in DNA damage checkpoint (GO:0072422)3.02713472
68somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.02582795
69somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.02582795
70isotype switching (GO:0045190)3.02582795
71signal transduction involved in cell cycle checkpoint (GO:0072395)3.02200085
72telomere maintenance via semi-conservative replication (GO:0032201)3.01540056
73DNA ligation (GO:0006266)3.01518721
74protein neddylation (GO:0045116)3.00817334
75RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.00659335
76CENP-A containing nucleosome assembly (GO:0034080)3.00545453
77water-soluble vitamin biosynthetic process (GO:0042364)2.99055026
78de novo posttranslational protein folding (GO:0051084)2.99026566
79DNA strand elongation (GO:0022616)2.98949109
80DNA replication initiation (GO:0006270)2.98763614
81glutamate secretion (GO:0014047)2.98244478
82* regulation of ubiquitin-protein transferase activity (GO:0051438)2.97908748
83ribosome biogenesis (GO:0042254)2.96862896
84protein targeting to mitochondrion (GO:0006626)2.96495935
85chromatin remodeling at centromere (GO:0031055)2.96262381
86regulation of helicase activity (GO:0051095)2.93891534
87respiratory electron transport chain (GO:0022904)2.93717405
887-methylguanosine mRNA capping (GO:0006370)2.93381516
89DNA deamination (GO:0045006)2.93311531
90establishment of viral latency (GO:0019043)2.93169627
91cell cycle G1/S phase transition (GO:0044843)2.92730975
92G1/S transition of mitotic cell cycle (GO:0000082)2.92730975
93negative regulation of mitotic sister chromatid separation (GO:2000816)2.90557270
94negative regulation of mitotic sister chromatid segregation (GO:0033048)2.90557270
95negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.90557270
96negative regulation of sister chromatid segregation (GO:0033046)2.90557270
97peptidyl-arginine methylation (GO:0018216)2.90464162
98peptidyl-arginine N-methylation (GO:0035246)2.90464162
99maturation of 5.8S rRNA (GO:0000460)2.89528541
100cytochrome complex assembly (GO:0017004)2.89513052
101electron transport chain (GO:0022900)2.89311513
102histone arginine methylation (GO:0034969)2.89218903
103peptidyl-histidine modification (GO:0018202)2.89088214
1047-methylguanosine RNA capping (GO:0009452)2.87343716
105RNA capping (GO:0036260)2.87343716
106DNA replication-dependent nucleosome assembly (GO:0006335)2.87197221
107DNA replication-dependent nucleosome organization (GO:0034723)2.87197221
108metaphase plate congression (GO:0051310)2.86013115
109IMP metabolic process (GO:0046040)2.85871585
110protein localization to mitochondrion (GO:0070585)2.84623663
111negative regulation of chromosome segregation (GO:0051985)2.84545940
112nucleotide-excision repair, DNA gap filling (GO:0006297)2.84474134
113RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.83838709
114tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.83838709
115protein K11-linked ubiquitination (GO:0070979)2.82126206
116protein-cofactor linkage (GO:0018065)2.82074986
117mitotic spindle assembly checkpoint (GO:0007094)2.81556389
118* regulation of ligase activity (GO:0051340)2.80844994
119establishment of protein localization to mitochondrion (GO:0072655)2.80795783
120negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.80451507
121kinetochore organization (GO:0051383)2.78012230
122mitotic sister chromatid segregation (GO:0000070)2.77944405
123antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.77058316
124negative regulation of microtubule polymerization (GO:0031115)2.76213882
125spindle assembly checkpoint (GO:0071173)2.75458282
126telomere maintenance via recombination (GO:0000722)2.75432509
127kinetochore assembly (GO:0051382)2.75285490
128histone H2A acetylation (GO:0043968)2.74962366
129chaperone-mediated protein transport (GO:0072321)2.74580185
130regulation of synaptic vesicle exocytosis (GO:2000300)2.73157258
131histone exchange (GO:0043486)2.72326941
132establishment of chromosome localization (GO:0051303)2.68064595
133L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.68036411
134sequestering of actin monomers (GO:0042989)2.64781041
135DNA replication-independent nucleosome assembly (GO:0006336)2.64602316
136DNA replication-independent nucleosome organization (GO:0034724)2.64602316
137regulation of mitochondrial translation (GO:0070129)2.64092797
138nucleobase-containing small molecule interconversion (GO:0015949)2.63968424
139regulation of sister chromatid segregation (GO:0033045)2.62473215
140regulation of mitotic sister chromatid separation (GO:0010965)2.62473215
141regulation of mitotic sister chromatid segregation (GO:0033047)2.62473215
142transcription elongation from RNA polymerase III promoter (GO:0006385)2.62022413
143termination of RNA polymerase III transcription (GO:0006386)2.62022413
144transcription-coupled nucleotide-excision repair (GO:0006283)2.61335605
145regulation of mitotic metaphase/anaphase transition (GO:0030071)2.61252525
146mitotic recombination (GO:0006312)2.61167076
147positive regulation of cell cycle arrest (GO:0071158)2.61001405
148pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.60555882
149regulation of centriole replication (GO:0046599)2.60007859
150spindle checkpoint (GO:0031577)2.58583307
151mitotic spindle checkpoint (GO:0071174)2.56816938

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.21628759
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.78551965
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.67009262
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.43512517
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.32463547
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.28053148
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.27265364
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.24895970
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.19375759
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.11111261
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.09972217
12RBPJ_22232070_ChIP-Seq_NCS_Mouse3.02950544
13* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.98827369
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.96054515
15* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.73831435
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64598939
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56565083
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.51699527
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.42094297
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28350205
21ZNF274_21170338_ChIP-Seq_K562_Hela2.26957376
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25145386
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.25127105
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22994298
25VDR_23849224_ChIP-Seq_CD4+_Human2.20739343
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18630586
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15583847
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15439050
29XRN2_22483619_ChIP-Seq_HELA_Human2.13764899
30* GABP_19822575_ChIP-Seq_HepG2_Human2.03595041
31VDR_22108803_ChIP-Seq_LS180_Human1.98812388
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94828370
33DCP1A_22483619_ChIP-Seq_HELA_Human1.94571770
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.87375103
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.83179734
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79510292
37IGF1R_20145208_ChIP-Seq_DFB_Human1.77878965
38* YY1_21170310_ChIP-Seq_MESCs_Mouse1.77306478
39FOXP3_21729870_ChIP-Seq_TREG_Human1.76223791
40* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76121893
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75707831
42ELK1_19687146_ChIP-ChIP_HELA_Human1.75392700
43TTF2_22483619_ChIP-Seq_HELA_Human1.75108423
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.74049396
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65663187
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61104070
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61087470
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59536401
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.58816248
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58764424
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58462749
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.54889935
53TAF15_26573619_Chip-Seq_HEK293_Human1.53019087
54AR_21909140_ChIP-Seq_LNCAP_Human1.52911878
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52044131
56* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50752671
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49750820
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.47195771
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47052815
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45076740
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40193261
62P300_19829295_ChIP-Seq_ESCs_Human1.38187116
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37427693
64* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.35976829
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33482406
66* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32939794
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32324413
68* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.30774165
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27883858
70* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27145749
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24292404
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20456203
73IRF1_19129219_ChIP-ChIP_H3396_Human1.19150651
74EZH2_22144423_ChIP-Seq_EOC_Human1.17480900
75* KDM5A_27292631_Chip-Seq_BREAST_Human1.14300492
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14132532
77* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12838940
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11072601
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09727689
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04926557
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04455516
82CIITA_25753668_ChIP-Seq_RAJI_Human1.03901207
83GBX2_23144817_ChIP-Seq_PC3_Human1.03668257
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03325371
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02430295
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00629216
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99114240
88NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96906937
89REST_18959480_ChIP-ChIP_MESCs_Mouse0.96828126
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96183782
91TP53_22573176_ChIP-Seq_HFKS_Human0.96171906
92SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95855531
93* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95581469
94MYC_18940864_ChIP-ChIP_HL60_Human0.94706624
95* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93675886
96EZH2_27294783_Chip-Seq_NPCs_Mouse0.93474740
97SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91373353
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91285904
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91247614
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91239871
101FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90665230
102NFE2_27457419_Chip-Seq_LIVER_Mouse0.90568491
103FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90529909
104CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90410878
105* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89550962
106PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89464229
107ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89398578
108KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89215514
109SOX2_16153702_ChIP-ChIP_HESCs_Human0.88785506
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88109810
111SOX9_26525672_Chip-Seq_HEART_Mouse0.87462552
112SOX2_19829295_ChIP-Seq_ESCs_Human0.86431128
113NANOG_19829295_ChIP-Seq_ESCs_Human0.86431128
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85519029
115CBP_20019798_ChIP-Seq_JUKART_Human0.85519029
116FUS_26573619_Chip-Seq_HEK293_Human0.84707866
117REST_21632747_ChIP-Seq_MESCs_Mouse0.83390559
118KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83351938
119NANOG_16153702_ChIP-ChIP_HESCs_Human0.82810417
120TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.82262644
121ER_23166858_ChIP-Seq_MCF-7_Human0.81806136
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81771475
123PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81758957
124ELK1_22589737_ChIP-Seq_MCF10A_Human0.81725511
125CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81664632
126EWS_26573619_Chip-Seq_HEK293_Human0.80936425
127CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.80692905
128* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.79708767
129NANOG_21062744_ChIP-ChIP_HESCs_Human0.79533586
130TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.78001315
131NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.77141867
132* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.76375336
133SALL1_21062744_ChIP-ChIP_HESCs_Human0.76125366
134POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.75542942
135BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75041357
136DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74736973
137CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.74403621

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.65925410
2MP0008877_abnormal_DNA_methylation3.60225473
3MP0003123_paternal_imprinting3.24410729
4MP0003880_abnormal_central_pattern2.95180769
5MP0003693_abnormal_embryo_hatching2.80553849
6MP0004957_abnormal_blastocyst_morpholog2.79770298
7MP0010094_abnormal_chromosome_stability2.68621873
8MP0002736_abnormal_nociception_after2.41230946
9MP0003111_abnormal_nucleus_morphology2.38257606
10MP0001968_abnormal_touch/_nociception2.37614234
11MP0008058_abnormal_DNA_repair2.31933560
12MP0003077_abnormal_cell_cycle2.30649689
13MP0006072_abnormal_retinal_apoptosis2.26786901
14MP0003635_abnormal_synaptic_transmissio2.25358062
15MP0003122_maternal_imprinting2.15420941
16MP0008932_abnormal_embryonic_tissue2.14059124
17MP0002653_abnormal_ependyma_morphology2.11644945
18MP0009697_abnormal_copulation2.11199151
19MP0003121_genomic_imprinting2.09999273
20MP0009046_muscle_twitch2.08600660
21MP0003787_abnormal_imprinting2.00177283
22MP0002735_abnormal_chemical_nociception1.98748992
23MP0008007_abnormal_cellular_replicative1.98158382
24MP0002063_abnormal_learning/memory/cond1.94488631
25MP0004270_analgesia1.86550497
26MP0002734_abnormal_mechanical_nocicepti1.83583051
27MP0002064_seizures1.75642931
28MP0009745_abnormal_behavioral_response1.75555029
29MP0003567_abnormal_fetal_cardiomyocyte1.62782067
30MP0002572_abnormal_emotion/affect_behav1.53865075
31MP0001529_abnormal_vocalization1.52673173
32MP0000372_irregular_coat_pigmentation1.52194919
33MP0004811_abnormal_neuron_physiology1.48666990
34MP0005499_abnormal_olfactory_system1.47798278
35MP0005394_taste/olfaction_phenotype1.47798278
36MP0006036_abnormal_mitochondrial_physio1.47767798
37MP0002184_abnormal_innervation1.44492742
38MP0001293_anophthalmia1.43532841
39MP0005253_abnormal_eye_physiology1.42336317
40MP0008995_early_reproductive_senescence1.41953580
41MP0002938_white_spotting1.38980941
42MP0008789_abnormal_olfactory_epithelium1.34370718
43MP0010030_abnormal_orbit_morphology1.34348221
44MP0005645_abnormal_hypothalamus_physiol1.33869902
45MP0004233_abnormal_muscle_weight1.32661501
46MP0002272_abnormal_nervous_system1.32434248
47MP0008872_abnormal_physiological_respon1.31108061
48MP0001730_embryonic_growth_arrest1.29135465
49MP0003941_abnormal_skin_development1.28034982
50MP0003786_premature_aging1.27834357
51MP0001970_abnormal_pain_threshold1.27375699
52MP0000350_abnormal_cell_proliferation1.24303492
53MP0001188_hyperpigmentation1.23951258
54MP0002160_abnormal_reproductive_system1.23825752
55MP0002733_abnormal_thermal_nociception1.23252510
56MP0005084_abnormal_gallbladder_morpholo1.22918599
57MP0000778_abnormal_nervous_system1.19743929
58MP0002067_abnormal_sensory_capabilities1.19591594
59MP0003806_abnormal_nucleotide_metabolis1.18895224
60MP0004215_abnormal_myocardial_fiber1.17896029
61MP0006276_abnormal_autonomic_nervous1.17589981
62MP0002751_abnormal_autonomic_nervous1.17067437
63MP0003937_abnormal_limbs/digits/tail_de1.16423960
64MP0008057_abnormal_DNA_replication1.12524073
65MP0005551_abnormal_eye_electrophysiolog1.11579872
66MP0000631_abnormal_neuroendocrine_gland1.10892763
67MP0002210_abnormal_sex_determination1.10865680
68MP0002234_abnormal_pharynx_morphology1.10009985
69MP0005646_abnormal_pituitary_gland1.09249296
70MP0002638_abnormal_pupillary_reflex1.07778815
71MP0001984_abnormal_olfaction1.07426033
72MP0001485_abnormal_pinna_reflex1.06696680
73MP0000647_abnormal_sebaceous_gland1.06646184
74MP0001177_atelectasis1.05567584
75MP0006292_abnormal_olfactory_placode1.04292716
76MP0005423_abnormal_somatic_nervous1.03839785
77MP0001697_abnormal_embryo_size1.03281097
78MP0003890_abnormal_embryonic-extraembry1.03079652
79MP0000955_abnormal_spinal_cord1.01249069
80MP0003186_abnormal_redox_activity1.00999057
81MP0002837_dystrophic_cardiac_calcinosis1.00274171
82MP0003698_abnormal_male_reproductive0.99584460
83MP0003879_abnormal_hair_cell0.98708575
84MP0001929_abnormal_gametogenesis0.96618087
85MP0002090_abnormal_vision0.94776117
86MP0002557_abnormal_social/conspecific_i0.94706435
87MP0003646_muscle_fatigue0.93988677
88MP0006035_abnormal_mitochondrial_morpho0.93351006
89MP0004924_abnormal_behavior0.92883997
90MP0005386_behavior/neurological_phenoty0.92883997
91MP0005187_abnormal_penis_morphology0.91977293
92MP0001905_abnormal_dopamine_level0.91281602
93MP0001145_abnormal_male_reproductive0.90599445
94MP0004742_abnormal_vestibular_system0.90259183
95MP0005410_abnormal_fertilization0.89209434
96MP0002822_catalepsy0.89094379
97MP0001919_abnormal_reproductive_system0.87876744
98MP0003718_maternal_effect0.86558507
99MP0001119_abnormal_female_reproductive0.86116437
100MP0002882_abnormal_neuron_morphology0.85972932
101MP0008569_lethality_at_weaning0.85539784
102MP0001440_abnormal_grooming_behavior0.85525493
103MP0003119_abnormal_digestive_system0.84432965
104MP0003861_abnormal_nervous_system0.84345504
105* MP0002080_prenatal_lethality0.84168034
106MP0003011_delayed_dark_adaptation0.83237182
107MP0001486_abnormal_startle_reflex0.82866743
108MP0002152_abnormal_brain_morphology0.82690110
109MP0003195_calcinosis0.82593808
110MP0004142_abnormal_muscle_tone0.82532682
111MP0002233_abnormal_nose_morphology0.82368428
112MP0001764_abnormal_homeostasis0.81842228
113MP0002163_abnormal_gland_morphology0.81393217
114MP0000358_abnormal_cell_content/0.79672732
115MP0000537_abnormal_urethra_morphology0.79514540
116MP0002085_abnormal_embryonic_tissue0.78817813
117MP0002066_abnormal_motor_capabilities/c0.78709992
118MP0005380_embryogenesis_phenotype0.78023501
119MP0001672_abnormal_embryogenesis/_devel0.78023501
120MP0001286_abnormal_eye_development0.77854954
121MP0004147_increased_porphyrin_level0.77644687
122MP0000653_abnormal_sex_gland0.76290180
123MP0002084_abnormal_developmental_patter0.76020467
124MP0002102_abnormal_ear_morphology0.74537763
125MP0005389_reproductive_system_phenotype0.73799735
126MP0000313_abnormal_cell_death0.73440138
127MP0003942_abnormal_urinary_system0.72641707
128MP0005367_renal/urinary_system_phenotyp0.71877848
129MP0000516_abnormal_urinary_system0.71877848
130MP0003984_embryonic_growth_retardation0.71767703
131MP0004133_heterotaxia0.70359557
132MP0000049_abnormal_middle_ear0.70100479
133MP0000534_abnormal_ureter_morphology0.69504236
134MP0009672_abnormal_birth_weight0.69034724
135MP0005171_absent_coat_pigmentation0.68580397
136MP0002161_abnormal_fertility/fecundity0.67264742
137MP0002088_abnormal_embryonic_growth/wei0.67198174
138MP0005379_endocrine/exocrine_gland_phen0.66869668

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)3.72177950
2Increased hepatocellular lipid droplets (HP:0006565)3.67577350
3Abnormality of the labia minora (HP:0012880)3.55626540
4Focal motor seizures (HP:0011153)3.49241896
5Acute encephalopathy (HP:0006846)3.43368284
6Lipid accumulation in hepatocytes (HP:0006561)3.39619463
7Myokymia (HP:0002411)3.35632067
8Increased serum pyruvate (HP:0003542)3.13885405
9Abnormality of glycolysis (HP:0004366)3.13885405
10Methylmalonic acidemia (HP:0002912)3.09820904
11Cerebral hypomyelination (HP:0006808)3.07385326
12Aplasia/Hypoplasia of the uvula (HP:0010293)2.98370061
13Chromosomal breakage induced by crosslinking agents (HP:0003221)2.95160582
14Abnormal hair whorl (HP:0010721)2.92946762
15Shoulder girdle muscle weakness (HP:0003547)2.91667168
16Neuroendocrine neoplasm (HP:0100634)2.88747623
17Epileptic encephalopathy (HP:0200134)2.88488642
18Abnormality of the anterior horn cell (HP:0006802)2.86117222
19Degeneration of anterior horn cells (HP:0002398)2.86117222
20Atonic seizures (HP:0010819)2.85183771
21Pheochromocytoma (HP:0002666)2.85172807
22Abnormality of chromosome stability (HP:0003220)2.84209301
23Chromsome breakage (HP:0040012)2.81823602
24Gait imbalance (HP:0002141)2.74819273
25Atrophy/Degeneration involving motor neurons (HP:0007373)2.73562310
26Abnormality of the preputium (HP:0100587)2.71484151
27Congenital primary aphakia (HP:0007707)2.61861438
28Hepatic necrosis (HP:0002605)2.59047165
29Cerebral edema (HP:0002181)2.57485466
30Abnormal mitochondria in muscle tissue (HP:0008316)2.57410751
31Medial flaring of the eyebrow (HP:0010747)2.55207042
32Renal Fanconi syndrome (HP:0001994)2.53627271
33Irregular epiphyses (HP:0010582)2.52458685
34Patellar aplasia (HP:0006443)2.48277211
35Nephrogenic diabetes insipidus (HP:0009806)2.47904426
36Febrile seizures (HP:0002373)2.47552412
37Methylmalonic aciduria (HP:0012120)2.46958445
38Acute necrotizing encephalopathy (HP:0006965)2.45924877
393-Methylglutaconic aciduria (HP:0003535)2.42789010
40Pancreatic cysts (HP:0001737)2.40893247
41Neoplasm of the peripheral nervous system (HP:0100007)2.36218437
42Poor suck (HP:0002033)2.33737087
43Aplasia/Hypoplasia of the patella (HP:0006498)2.32345878
44Amyotrophic lateral sclerosis (HP:0007354)2.29350185
45Abnormality of methionine metabolism (HP:0010901)2.28883841
46Lactic acidosis (HP:0003128)2.25661635
47Unsteady gait (HP:0002317)2.21088072
48Exertional dyspnea (HP:0002875)2.20767306
49Abnormality of serum amino acid levels (HP:0003112)2.17780531
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.15747921
51True hermaphroditism (HP:0010459)2.15712865
52Abnormality of aspartate family amino acid metabolism (HP:0010899)2.15370665
53Abnormality of midbrain morphology (HP:0002418)2.15241596
54Molar tooth sign on MRI (HP:0002419)2.15241596
55Agnosia (HP:0010524)2.15209351
56Postnatal microcephaly (HP:0005484)2.14668962
57Congenital, generalized hypertrichosis (HP:0004540)2.14495351
58Abnormality of the lower motor neuron (HP:0002366)2.14103076
59Abnormality of the duodenum (HP:0002246)2.13474475
60Nephronophthisis (HP:0000090)2.09837710
61Progressive cerebellar ataxia (HP:0002073)2.09081332
62Leukodystrophy (HP:0002415)2.08631453
63Increased CSF lactate (HP:0002490)2.06830811
64Progressive macrocephaly (HP:0004481)2.05159543
65Poor coordination (HP:0002370)2.04987739
66Absence seizures (HP:0002121)2.03778158
67Type I transferrin isoform profile (HP:0003642)2.03669481
68Pelvic girdle muscle weakness (HP:0003749)2.03533334
69Hypoplasia of the pons (HP:0012110)2.02267682
70Optic disc pallor (HP:0000543)2.02092561
71Hyperglycinemia (HP:0002154)2.01870807
72Increased intramyocellular lipid droplets (HP:0012240)2.01581029
73Tongue fasciculations (HP:0001308)2.01531316
74Type 2 muscle fiber atrophy (HP:0003554)2.01220089
75Lissencephaly (HP:0001339)2.00660382
76Ependymoma (HP:0002888)1.99397404
77Pendular nystagmus (HP:0012043)1.99082338
78Mitochondrial inheritance (HP:0001427)1.97991427
79Carpal bone hypoplasia (HP:0001498)1.97916683
80Decreased activity of mitochondrial respiratory chain (HP:0008972)1.97196413
81Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.97196413
82Hypoplasia of the capital femoral epiphysis (HP:0003090)1.95268929
83Fetal akinesia sequence (HP:0001989)1.94325627
84Oral leukoplakia (HP:0002745)1.94126373
85Hepatocellular necrosis (HP:0001404)1.93684560
86Focal seizures (HP:0007359)1.93462987
87Sloping forehead (HP:0000340)1.92169026
88Abnormality of the musculature of the pelvis (HP:0001469)1.91891067
89Abnormality of the hip-girdle musculature (HP:0001445)1.91891067
90Neoplasm of the adrenal gland (HP:0100631)1.91718801
91Volvulus (HP:0002580)1.91503875
92Respiratory failure (HP:0002878)1.91083602
93Breast hypoplasia (HP:0003187)1.90891430
94Triphalangeal thumb (HP:0001199)1.90102883
95Colon cancer (HP:0003003)1.89927427
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89329404
97Abnormality of alanine metabolism (HP:0010916)1.89329404
98Hyperalaninemia (HP:0003348)1.89329404
99Failure to thrive in infancy (HP:0001531)1.87847040
100Broad foot (HP:0001769)1.87576130
101Neuroblastic tumors (HP:0004376)1.87448936
102Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.87448936
103Neuroblastoma (HP:0003006)1.87448936
104Primitive neuroectodermal tumor (HP:0030065)1.87448936
105Medulloblastoma (HP:0002885)1.87430010
106Abnormality of the vitamin B12 metabolism (HP:0004341)1.86425067
107Abnormal lung lobation (HP:0002101)1.86310286
108Poor head control (HP:0002421)1.85950796
109Clubbing of toes (HP:0100760)1.85657245
110Progressive inability to walk (HP:0002505)1.85443815
111Respiratory difficulties (HP:0002880)1.84862104
112Lethargy (HP:0001254)1.84067894
113Hypothermia (HP:0002045)1.83734758
114Meckel diverticulum (HP:0002245)1.81890862
115Exercise intolerance (HP:0003546)1.80690015
116Absent epiphyses (HP:0010577)1.80689604
117Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.80689604
118Abnormal glycosylation (HP:0012345)1.80678438
119Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80678438
120Abnormal protein N-linked glycosylation (HP:0012347)1.80678438
121Abnormal protein glycosylation (HP:0012346)1.80678438
122Glioma (HP:0009733)1.80091967
123Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.79449792
124Muscle fiber atrophy (HP:0100295)1.78868478
125Abnormality of vitamin B metabolism (HP:0004340)1.78699046
126Vaginal atresia (HP:0000148)1.77525135
127Abnormality of the ileum (HP:0001549)1.77308211
128Intestinal atresia (HP:0011100)1.77023068
129Abolished electroretinogram (ERG) (HP:0000550)1.75786287
130Genital tract atresia (HP:0001827)1.75565328
131Septo-optic dysplasia (HP:0100842)1.73907893
132Heterochromia iridis (HP:0001100)1.73699424
133Increased serum lactate (HP:0002151)1.73168540
134Megaloblastic anemia (HP:0001889)1.71763398
135Visual hallucinations (HP:0002367)1.70067150
136CNS hypomyelination (HP:0003429)1.69993877
137Abnormality of the carotid arteries (HP:0005344)1.69796971
138Aplasia/Hypoplasia of the sternum (HP:0006714)1.69745388
139Cleft eyelid (HP:0000625)1.69687234
140Papillary thyroid carcinoma (HP:0002895)1.69647987
141Horseshoe kidney (HP:0000085)1.69551183
142Limb dystonia (HP:0002451)1.69346107
143Specific learning disability (HP:0001328)1.68969620
144Delusions (HP:0000746)1.68746245
145Stenosis of the external auditory canal (HP:0000402)1.68571273
146Emotional lability (HP:0000712)1.68076563
147Abnormality of glycine metabolism (HP:0010895)1.67786776
148Abnormality of serine family amino acid metabolism (HP:0010894)1.67786776
149Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67775967
150Breast aplasia (HP:0100783)1.67082223
151Pancytopenia (HP:0001876)1.66652136
152Muscle fibrillation (HP:0010546)1.64923328
153Aplastic anemia (HP:0001915)1.64472252
154Pancreatic fibrosis (HP:0100732)1.63684552
155Supernumerary spleens (HP:0009799)1.62184443
156Dialeptic seizures (HP:0011146)1.61501773
157Impaired vibration sensation in the lower limbs (HP:0002166)1.61334620
158Broad-based gait (HP:0002136)1.60324221
159Premature graying of hair (HP:0002216)1.59181212
160Embryonal renal neoplasm (HP:0011794)1.58328831
161Abnormality of the pons (HP:0007361)1.58198143
162Small intestinal stenosis (HP:0012848)1.57848177
163Duodenal stenosis (HP:0100867)1.57848177
164Rough bone trabeculation (HP:0100670)1.56376876

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K123.19811473
2EIF2AK13.14005366
3NEK13.13062489
4CDK193.01532280
5BUB12.98357378
6TRIM282.96013363
7VRK22.84913121
8TSSK62.83078352
9CASK2.79902904
10TESK12.73510002
11MST42.69306163
12CCNB12.66767008
13NUAK12.56379740
14ZAK2.40048782
15TESK22.33019052
16CDC72.26665536
17WNK32.24074735
18LIMK12.22200825
19WEE12.14633533
20PLK22.01707787
21MINK11.92904077
22DAPK11.89717241
23MAP2K71.85580940
24MARK11.81684934
25MAP4K21.81049823
26SIK31.81016502
27STK161.79909231
28PDK31.75092318
29PDK41.75092318
30SRPK11.74627427
31PLK41.71024888
32PLK31.70126918
33BRSK11.69156278
34NTRK31.64801609
35ACVR1B1.64686139
36ERBB31.58711284
37TAF11.58178287
38MAP3K41.57246705
39SCYL21.44692769
40AKT31.33852225
41BRSK21.33257982
42EIF2AK31.31404833
43FRK1.28128334
44TNIK1.26808028
45MKNK11.24443999
46CSNK1G11.23324691
47PRPF4B1.22589878
48CSNK1G31.20821843
49BCR1.19740469
50VRK11.18831818
51CSNK1G21.15523158
52PLK11.09383386
53MKNK21.08385698
54PDK21.02678928
55BRAF1.01785102
56CDK180.99884351
57CDK140.95430087
58OXSR10.94014876
59NME10.93006013
60CSNK1A1L0.92535724
61KSR10.90518613
62MAPK130.90027033
63DYRK20.89642647
64DAPK20.89341436
65CDK80.87484508
66BCKDK0.87355123
67CDK150.87309193
68CDK11A0.85453977
69AURKA0.84902728
70PRKCG0.84769636
71TLK10.83964915
72MAP3K90.83957852
73GRK10.83376752
74ADRBK20.79210588
75LATS20.78012340
76EPHA40.77509140
77RPS6KA40.76439783
78MAP2K40.72698863
79DYRK30.71412609
80STK390.70743997
81NTRK20.68949376
82NEK20.68847791
83YES10.64483803
84INSRR0.63867620
85ATR0.62591392
86MAP3K110.61980070
87PASK0.61175614
88ARAF0.60089131
89ATM0.59618506
90PNCK0.59379555
91CLK10.58439971
92PRKD30.56489506
93AURKB0.56109765
94CAMKK20.54191822
95PAK40.53460831
96PIM20.51637783
97TAOK20.51083541
98TTK0.51046359
99CAMKK10.49347502
100BMPR1B0.49168347
101TXK0.48048286
102CHEK20.47278892
103STK30.47182886
104PRKCE0.47157920
105TGFBR10.47104318
106SGK20.47064103
107PAK30.46886862
108CDK50.45846690
109STK38L0.44997283
110CHEK10.44119559
111PAK10.43375574
112MYLK0.42595662
113ALK0.41709267
114PINK10.39844198
115DAPK30.39398798
116ILK0.39363420
117CDK30.39091150
118CSNK2A10.37701618
119UHMK10.37455677
120PAK60.35455705
121CDK20.33827498
122CSNK1A10.33101960
123CSNK1E0.32468138
124CAMK2A0.32108657
125RPS6KA50.31876917
126CDK10.31696314
127BMPR20.31248398
128GRK50.30846440
129CDK70.29881013
130LMTK20.29605059
131PRKCI0.28612735
132SGK2230.27159858
133SGK4940.27159858
134NLK0.27047769
135EIF2AK20.26750372
136KDR0.26367965
137FGFR10.26035444
138CSNK2A20.25822895
139PBK0.24610415

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.28115952
2DNA replication_Homo sapiens_hsa030303.27679050
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.86942308
4Synaptic vesicle cycle_Homo sapiens_hsa047212.78869550
5Mismatch repair_Homo sapiens_hsa034302.78536540
6RNA polymerase_Homo sapiens_hsa030202.55919253
7Spliceosome_Homo sapiens_hsa030402.54312217
8RNA transport_Homo sapiens_hsa030132.46364177
9Base excision repair_Homo sapiens_hsa034102.11857745
10Cell cycle_Homo sapiens_hsa041102.11487623
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.03775911
12Nucleotide excision repair_Homo sapiens_hsa034201.97298156
13Homologous recombination_Homo sapiens_hsa034401.91096612
14Oocyte meiosis_Homo sapiens_hsa041141.90910193
15Collecting duct acid secretion_Homo sapiens_hsa049661.89383444
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86804888
17Propanoate metabolism_Homo sapiens_hsa006401.80665158
18Nicotine addiction_Homo sapiens_hsa050331.78633322
19Pyrimidine metabolism_Homo sapiens_hsa002401.71931627
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.70379435
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.68625212
22Basal transcription factors_Homo sapiens_hsa030221.66323661
23Vibrio cholerae infection_Homo sapiens_hsa051101.58074753
24mRNA surveillance pathway_Homo sapiens_hsa030151.54452950
25Parkinsons disease_Homo sapiens_hsa050121.49168587
26Oxidative phosphorylation_Homo sapiens_hsa001901.46533280
27RNA degradation_Homo sapiens_hsa030181.42062841
28Huntingtons disease_Homo sapiens_hsa050161.38687910
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35866629
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35634744
31Fatty acid elongation_Homo sapiens_hsa000621.33111747
32Steroid biosynthesis_Homo sapiens_hsa001001.31454936
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27601422
34Pyruvate metabolism_Homo sapiens_hsa006201.24828444
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24422231
36Olfactory transduction_Homo sapiens_hsa047401.22709993
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22247683
38Fanconi anemia pathway_Homo sapiens_hsa034601.20001885
39Long-term potentiation_Homo sapiens_hsa047201.17425533
40Purine metabolism_Homo sapiens_hsa002301.14736287
41Amphetamine addiction_Homo sapiens_hsa050311.14272633
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13287071
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12783265
44* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11817225
45Dopaminergic synapse_Homo sapiens_hsa047281.11474053
46Epstein-Barr virus infection_Homo sapiens_hsa051691.11302777
47Type I diabetes mellitus_Homo sapiens_hsa049401.10979591
48Caffeine metabolism_Homo sapiens_hsa002321.04005191
49Circadian entrainment_Homo sapiens_hsa047131.02442852
50Ribosome_Homo sapiens_hsa030101.00060885
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99281464
52Vitamin B6 metabolism_Homo sapiens_hsa007500.99107162
53Butanoate metabolism_Homo sapiens_hsa006500.97962905
54Selenocompound metabolism_Homo sapiens_hsa004500.96774291
55GABAergic synapse_Homo sapiens_hsa047270.95077049
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93056259
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92160639
58Folate biosynthesis_Homo sapiens_hsa007900.87798825
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87372353
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85131101
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81716374
62Morphine addiction_Homo sapiens_hsa050320.80995650
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78628383
64p53 signaling pathway_Homo sapiens_hsa041150.78503301
65Alcoholism_Homo sapiens_hsa050340.76999093
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75459553
67Alzheimers disease_Homo sapiens_hsa050100.72641693
68Cardiac muscle contraction_Homo sapiens_hsa042600.72382111
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71063448
70Glutamatergic synapse_Homo sapiens_hsa047240.67505540
71Shigellosis_Homo sapiens_hsa051310.65510974
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.64737693
73Phagosome_Homo sapiens_hsa041450.64240507
74Metabolic pathways_Homo sapiens_hsa011000.63669393
75Protein export_Homo sapiens_hsa030600.62831238
76Sulfur metabolism_Homo sapiens_hsa009200.62419093
77Peroxisome_Homo sapiens_hsa041460.60848923
78One carbon pool by folate_Homo sapiens_hsa006700.60765558
79Colorectal cancer_Homo sapiens_hsa052100.59889810
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59301586
81Glutathione metabolism_Homo sapiens_hsa004800.58596645
82Long-term depression_Homo sapiens_hsa047300.57422913
83Biosynthesis of amino acids_Homo sapiens_hsa012300.56170410
84Gap junction_Homo sapiens_hsa045400.55838858
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55800507
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54367857
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54071082
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53576963
89Rheumatoid arthritis_Homo sapiens_hsa053230.52900109
90Non-homologous end-joining_Homo sapiens_hsa034500.52105361
91Legionellosis_Homo sapiens_hsa051340.51683837
92Hippo signaling pathway_Homo sapiens_hsa043900.51663975
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47990924
94Tryptophan metabolism_Homo sapiens_hsa003800.46647406
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45318880
96beta-Alanine metabolism_Homo sapiens_hsa004100.44856411
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44459960
98Fatty acid metabolism_Homo sapiens_hsa012120.44407516
99Cholinergic synapse_Homo sapiens_hsa047250.44098397
100Viral carcinogenesis_Homo sapiens_hsa052030.43658487
101Thyroid cancer_Homo sapiens_hsa052160.42889721
102Taste transduction_Homo sapiens_hsa047420.42807451
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41382730
104Serotonergic synapse_Homo sapiens_hsa047260.40837493
105Insulin secretion_Homo sapiens_hsa049110.40819881
106HTLV-I infection_Homo sapiens_hsa051660.40638776
107Oxytocin signaling pathway_Homo sapiens_hsa049210.39833166
108Carbon metabolism_Homo sapiens_hsa012000.39374947
109Pentose phosphate pathway_Homo sapiens_hsa000300.35494626
110Calcium signaling pathway_Homo sapiens_hsa040200.34990980
111Nitrogen metabolism_Homo sapiens_hsa009100.34981087
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.34324879
113Cocaine addiction_Homo sapiens_hsa050300.34102176
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34074623
115N-Glycan biosynthesis_Homo sapiens_hsa005100.33392170
116Fatty acid degradation_Homo sapiens_hsa000710.33143036
117Primary immunodeficiency_Homo sapiens_hsa053400.32971078
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32666712
119Glioma_Homo sapiens_hsa052140.32502696
120Gastric acid secretion_Homo sapiens_hsa049710.31438052
121Fructose and mannose metabolism_Homo sapiens_hsa000510.31264905
122HIF-1 signaling pathway_Homo sapiens_hsa040660.30724942
123Endocytosis_Homo sapiens_hsa041440.30651500
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30201782
125Wnt signaling pathway_Homo sapiens_hsa043100.29235293
126Regulation of autophagy_Homo sapiens_hsa041400.28617200
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28606325
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28577531
129ErbB signaling pathway_Homo sapiens_hsa040120.28404863
130Endometrial cancer_Homo sapiens_hsa052130.27562257
131Axon guidance_Homo sapiens_hsa043600.27432600
132Renin-angiotensin system_Homo sapiens_hsa046140.27146085
133Salmonella infection_Homo sapiens_hsa051320.26303618
134Ether lipid metabolism_Homo sapiens_hsa005650.25906760
135Melanoma_Homo sapiens_hsa052180.25477520
136Phototransduction_Homo sapiens_hsa047440.25170062
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23293461
138Linoleic acid metabolism_Homo sapiens_hsa005910.23070344
139Vitamin digestion and absorption_Homo sapiens_hsa049770.20971059
140Drug metabolism - other enzymes_Homo sapiens_hsa009830.19125411
141Arginine and proline metabolism_Homo sapiens_hsa003300.19042253
142Chemical carcinogenesis_Homo sapiens_hsa052040.18923599
143Sulfur relay system_Homo sapiens_hsa041220.17829631
144Retinol metabolism_Homo sapiens_hsa008300.17012273
145Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.16523973
146Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.14462307
147alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.14147555

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