UBE2M

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)6.76976557
2establishment of apical/basal cell polarity (GO:0035089)5.25113135
3ribosomal small subunit biogenesis (GO:0042274)5.12850914
4transcription from mitochondrial promoter (GO:0006390)5.09204141
5regulation of mammary gland epithelial cell proliferation (GO:0033599)5.05661995
6embryonic process involved in female pregnancy (GO:0060136)5.00073178
7regulation of integrin activation (GO:0033623)4.92751958
8proline metabolic process (GO:0006560)4.83607108
9regulation of translational fidelity (GO:0006450)4.77882747
10mitotic G1 DNA damage checkpoint (GO:0031571)4.70459047
11negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.58316046
12establishment or maintenance of monopolar cell polarity (GO:0061339)4.50813354
13establishment of monopolar cell polarity (GO:0061162)4.50813354
14maternal placenta development (GO:0001893)4.42891260
15apoptotic process involved in morphogenesis (GO:0060561)4.36334190
16positive regulation of protein homooligomerization (GO:0032464)4.16621852
17positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling4.16085054
18negative regulation of cell size (GO:0045792)4.12494039
19regulation of early endosome to late endosome transport (GO:2000641)4.11285869
20negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.11007251
21protein localization to endosome (GO:0036010)4.10217169
22mitotic G1/S transition checkpoint (GO:0044819)4.00720998
23regulation of protein homooligomerization (GO:0032462)3.96423685
24protein retention in ER lumen (GO:0006621)3.89863978
25negative regulation of Ras GTPase activity (GO:0034261)3.89657038
26spliceosomal tri-snRNP complex assembly (GO:0000244)3.87102993
27mitochondrial DNA metabolic process (GO:0032042)3.81094443
28G1 DNA damage checkpoint (GO:0044783)3.80541427
29Golgi transport vesicle coating (GO:0048200)3.79990840
30COPI coating of Golgi vesicle (GO:0048205)3.79990840
31plasma membrane repair (GO:0001778)3.70825006
32protein maturation by protein folding (GO:0022417)3.69922754
33dosage compensation (GO:0007549)3.67615827
34negative regulation of potassium ion transmembrane transport (GO:1901380)3.66712415
35maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.61918341
36negative regulation of nucleotide catabolic process (GO:0030812)3.57503272
37trophectodermal cell differentiation (GO:0001829)3.56340192
38regulation of glucocorticoid metabolic process (GO:0031943)3.55240511
39oxidative demethylation (GO:0070989)3.52825980
40intracellular estrogen receptor signaling pathway (GO:0030520)3.51747032
41DNA deamination (GO:0045006)3.50502358
42regulation of hippo signaling (GO:0035330)3.50113843
43mitochondrial fusion (GO:0008053)3.46489573
44heterochromatin organization (GO:0070828)3.45661542
45regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 3.44294509
46nucleobase-containing small molecule interconversion (GO:0015949)3.42031622
47embryonic placenta development (GO:0001892)3.40847767
48negative regulation of erythrocyte differentiation (GO:0045647)3.40124917
49peptidyl-arginine omega-N-methylation (GO:0035247)3.36387701
50negative regulation of JAK-STAT cascade (GO:0046426)3.35575698
51stress fiber assembly (GO:0043149)3.34845393
52replication fork processing (GO:0031297)3.30719005
53apoptotic process involved in development (GO:1902742)3.27499510
54positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling3.24537561
55regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 3.24537561
56negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.24033562
57negative regulation of fatty acid biosynthetic process (GO:0045717)3.22612113
58retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.22534762
59DNA unwinding involved in DNA replication (GO:0006268)3.18944529
60planar cell polarity pathway involved in neural tube closure (GO:0090179)3.12162713
61protein complex localization (GO:0031503)3.10122676
62mitotic chromosome condensation (GO:0007076)3.10041481
63negative regulation of purine nucleotide catabolic process (GO:0033122)3.09266278
64signal complex assembly (GO:0007172)3.08426607
65regulation of response to osmotic stress (GO:0047484)3.07754888
66activation of Rac GTPase activity (GO:0032863)3.06938333
67regulation of cell size (GO:0008361)3.06680076
68maturation of SSU-rRNA (GO:0030490)3.03737369
69viral transcription (GO:0019083)3.03117630
70cellular protein complex localization (GO:0034629)3.01612974
71negative regulation of cell cycle arrest (GO:0071157)3.01145737
72cellular response to zinc ion (GO:0071294)2.99669979
73negative regulation of heart growth (GO:0061117)2.99273980
74negative regulation of cardiac muscle tissue growth (GO:0055022)2.99273980
75negative regulation of protein oligomerization (GO:0032460)2.98318999
76adherens junction assembly (GO:0034333)2.97170953
77nuclear envelope reassembly (GO:0031468)2.96872280
78mitotic nuclear envelope reassembly (GO:0007084)2.96872280
793-UTR-mediated mRNA stabilization (GO:0070935)2.96425480
80labyrinthine layer development (GO:0060711)2.94759091
81regulation of translational termination (GO:0006449)2.94158281
82histone arginine methylation (GO:0034969)2.94016574
83formation of translation preinitiation complex (GO:0001731)2.93655699
84mRNA cleavage (GO:0006379)2.93497463
85pre-miRNA processing (GO:0031054)2.93264695
86cell migration in hindbrain (GO:0021535)2.91727930
87regulation of tight junction assembly (GO:2000810)2.91432489
88regulation of NFAT protein import into nucleus (GO:0051532)2.90580985
89sarcomere organization (GO:0045214)2.90483655
90positive regulation of protein oligomerization (GO:0032461)2.90463100
91positive regulation of myotube differentiation (GO:0010831)2.89564941
92nodal signaling pathway (GO:0038092)2.88784969
93hypotonic response (GO:0006971)2.88388464
94glutamine family amino acid biosynthetic process (GO:0009084)2.88169653
95vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.86399102
96pentose-phosphate shunt (GO:0006098)2.83842788
97anatomical structure regression (GO:0060033)2.83738269
98synaptic vesicle docking involved in exocytosis (GO:0016081)2.83639903
99focal adhesion assembly (GO:0048041)2.82980481
100cell-substrate adherens junction assembly (GO:0007045)2.82980481
101peptidyl-arginine N-methylation (GO:0035246)2.82282972
102peptidyl-arginine methylation (GO:0018216)2.82282972
103regulation of gene silencing by RNA (GO:0060966)2.82273726
104regulation of posttranscriptional gene silencing (GO:0060147)2.82273726
105regulation of gene silencing by miRNA (GO:0060964)2.82273726
106negative regulation of focal adhesion assembly (GO:0051895)2.81757425
107negative regulation of cell junction assembly (GO:1901889)2.81757425
108negative regulation of adherens junction organization (GO:1903392)2.81757425
109carnitine shuttle (GO:0006853)2.81543058
110modulation by symbiont of host cellular process (GO:0044068)2.81301883
111regulation of protein oligomerization (GO:0032459)2.81043571
112protein localization to microtubule (GO:0035372)2.79990972
113polarized epithelial cell differentiation (GO:0030859)2.79692591
114regulation of apoptotic process involved in morphogenesis (GO:1902337)2.78208661
115positive regulation of lamellipodium assembly (GO:0010592)2.76878911
116convergent extension (GO:0060026)2.76022977
117modulation by virus of host process (GO:0019054)2.75821835
118embryonic camera-type eye development (GO:0031076)2.74183165
119activation of MAPKKK activity (GO:0000185)2.73564740
120glucose 6-phosphate metabolic process (GO:0051156)2.72525802
121glucose catabolic process (GO:0006007)2.72508948
122negative regulation of GTPase activity (GO:0034260)2.72507331
123negative regulation of GTP catabolic process (GO:0033125)2.72507331
124cardiac myofibril assembly (GO:0055003)2.71998912
125endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.71052384
126cellular hyperosmotic response (GO:0071474)2.70637901
127regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.70006039
128maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.69770749
129barbed-end actin filament capping (GO:0051016)2.69402873
130cytoskeletal anchoring at plasma membrane (GO:0007016)2.68105919
131translational termination (GO:0006415)2.67766945
132regulation of chromatin binding (GO:0035561)2.67300039
133lymph vessel development (GO:0001945)2.67069002
134regulation of podosome assembly (GO:0071801)2.63342062
135negative regulation of glial cell proliferation (GO:0060253)2.62153758
136cardiac muscle contraction (GO:0060048)2.61715312
137anterior/posterior axis specification, embryo (GO:0008595)2.60673512
138regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.59542577
139diaphragm development (GO:0060539)2.59515045
140translational elongation (GO:0006414)2.59412112
1414-hydroxyproline metabolic process (GO:0019471)2.58487543
142establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.58314268
143mitochondrion transport along microtubule (GO:0047497)2.58314268
144positive regulation of protein dephosphorylation (GO:0035307)2.58253195
145protein heterotrimerization (GO:0070208)2.58013766
146respiratory system process (GO:0003016)2.57330801
147cardiac muscle cell development (GO:0055013)2.57231974
148deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.57115656
149protein targeting to plasma membrane (GO:0072661)2.57054508
150negative regulation of mRNA processing (GO:0050686)2.56565924
151negative regulation of striated muscle cell differentiation (GO:0051154)2.56353926
152regulation of glucose import in response to insulin stimulus (GO:2001273)2.56247816
153protein insertion into membrane (GO:0051205)2.55308857
154intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.54926342
155ribonucleoprotein complex biogenesis (GO:0022613)2.53527996
156nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.53348903
157cell-cell junction maintenance (GO:0045217)2.53300485
158negative regulation of skeletal muscle tissue development (GO:0048642)2.50767455
159modulation by virus of host morphology or physiology (GO:0019048)2.48533580
160mRNA stabilization (GO:0048255)2.48185148
161RNA stabilization (GO:0043489)2.48185148
162NADH metabolic process (GO:0006734)2.46627497
163activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.46198283
164negative regulation of necroptotic process (GO:0060546)2.45912859
165skeletal muscle organ development (GO:0060538)2.45244485
166positive regulation of hair follicle development (GO:0051798)2.45204595
167positive regulation of hair cycle (GO:0042635)2.45204595
168response to parathyroid hormone (GO:0071107)2.44864278
169positive regulation of synapse maturation (GO:0090129)2.42088384
170cell-substrate junction assembly (GO:0007044)2.41422528
171positive regulation of protein export from nucleus (GO:0046827)2.40302273
172positive regulation of nuclease activity (GO:0032075)2.39810809
173positive regulation of mitochondrion organization (GO:0010822)2.36499634
174glutamate secretion (GO:0014047)2.35446291

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.81741415
2LXR_22292898_ChIP-Seq_THP-1_Human2.72871881
3VDR_21846776_ChIP-Seq_THP-1_Human2.72845404
4MYC_22102868_ChIP-Seq_BL_Human2.55306971
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.49462662
6ZNF263_19887448_ChIP-Seq_K562_Human2.48464371
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.32684140
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.31686922
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.30687211
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29374536
11KDM2B_26808549_Chip-Seq_DND41_Human2.28967251
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.27572531
13ZFP281_18757296_ChIP-ChIP_E14_Mouse2.25208045
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.19676072
15E2F7_22180533_ChIP-Seq_HELA_Human2.14357406
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.08214774
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03325959
18RACK7_27058665_Chip-Seq_MCF-7_Human2.01675818
19SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.99532655
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.96985783
21DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.96652728
22KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.93399464
23FOXM1_23109430_ChIP-Seq_U2OS_Human1.87463582
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.86226235
25NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.81260834
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.78032007
27STAT3_1855785_ChIP-Seq_MESCs_Mouse1.77275243
28ZFP281_27345836_Chip-Seq_ESCs_Mouse1.76834944
29TCF7_22412390_ChIP-Seq_EML_Mouse1.76805086
30* XRN2_22483619_ChIP-Seq_HELA_Human1.71815890
31CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.66902392
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62786059
33* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.62710843
34KDM2B_26808549_Chip-Seq_K562_Human1.61907035
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.60764051
36* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.59424466
37P300_27058665_Chip-Seq_ZR-75-30cells_Human1.59194320
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.58767215
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58162522
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51138345
41P68_20966046_ChIP-Seq_HELA_Human1.50677090
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49355409
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49234330
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.49132330
45* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47257688
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.46840118
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.46488494
48KDM2B_26808549_Chip-Seq_JURKAT_Human1.46373661
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45968496
50CREB1_26743006_Chip-Seq_LNCaP_Human1.44404925
51ATF3_27146783_Chip-Seq_COLON_Human1.44252160
52CTCF_27219007_Chip-Seq_ERYTHROID_Human1.42991916
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.42342526
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.42342526
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.42342526
56* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41141163
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39162135
58POU5F1_16518401_ChIP-PET_MESCs_Mouse1.39044963
59ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.38626448
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38030825
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38020940
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38013509
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.36674791
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.34974249
65BCOR_27268052_Chip-Seq_Bcells_Human1.34574018
66MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33466317
67* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32409234
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31040672
69MAF_26560356_Chip-Seq_TH1_Human1.30011512
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29786794
71SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.29345935
72CTCF_21964334_ChIP-Seq_BJAB-B_Human1.29333012
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28795840
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28787901
75ELF1_20517297_ChIP-Seq_JURKAT_Human1.28727094
76BCL6_27268052_Chip-Seq_Bcells_Human1.27006705
77NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.26421927
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24918680
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24660067
80NANOG_21062744_ChIP-ChIP_HESCs_Human1.23917044
81TP53_22127205_ChIP-Seq_IMR90_Human1.22935614
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22405564
83CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21056419
84* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20851218
85UTX_26944678_Chip-Seq_JUKART_Human1.20582133
86WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19323251
87PHF8_20622854_ChIP-Seq_HELA_Human1.19277126
88SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.17224374
89STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17205666
90YY1_22570637_ChIP-Seq_MALME-3M_Human1.15393768
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.14342995
92SMC4_20622854_ChIP-Seq_HELA_Human1.14085541
93HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13719693
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13645411
95* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13157009
96TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12870716
97E2F1_20622854_ChIP-Seq_HELA_Human1.12765432
98MAF_26560356_Chip-Seq_TH2_Human1.12723769
99NCOR1_26117541_ChIP-Seq_K562_Human1.12008175
100VDR_24763502_ChIP-Seq_THP-1_Human1.11999917
101* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11494956
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10931487
103KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10276051
104* FOXP1_21924763_ChIP-Seq_HESCs_Human1.10270783
105TRIM28_21343339_ChIP-Seq_HEK293_Human1.09351647
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08804173
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08700031
108TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07708772
109TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07685088
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07538411
111NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.07273923
112CTCF_27219007_Chip-Seq_Bcells_Human1.07247521
113CLOCK_20551151_ChIP-Seq_293T_Human1.07068219
114* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07046331
115* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07000284
116NELFA_20434984_ChIP-Seq_ESCs_Mouse1.06841707
117CTCF_21964334_Chip-Seq_Bcells_Human1.06692618
118MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06257092
119POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05603693
120JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05562205
121CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05554299
122SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04005508
123TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03586220
124DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03535610
125MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02586017
126NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01622493
127EGR1_19374776_ChIP-ChIP_THP-1_Human1.01459453
128EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01429818
129RARA_24833708_ChIP-Seq_LIVER_Mouse0.98643098
130SPI1_20517297_ChIP-Seq_HL60_Human0.98576928
131GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98543461
132ESR2_21235772_ChIP-Seq_MCF-7_Human0.98047775

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.92361863
2MP0003705_abnormal_hypodermis_morpholog3.76446209
3MP0004233_abnormal_muscle_weight3.67126882
4MP0005451_abnormal_body_composition3.51529369
5MP0009278_abnormal_bone_marrow3.42684786
6MP0000751_myopathy3.03164568
7MP0003123_paternal_imprinting2.71397970
8MP0010030_abnormal_orbit_morphology2.69395206
9MP0005076_abnormal_cell_differentiation2.58792016
10MP0010352_gastrointestinal_tract_polyps2.43778027
11MP0000678_abnormal_parathyroid_gland2.37776950
12MP0002269_muscular_atrophy2.29369021
13MP0003646_muscle_fatigue2.25731849
14MP0002653_abnormal_ependyma_morphology2.17291756
15MP0005330_cardiomyopathy2.14638964
16MP0002837_dystrophic_cardiac_calcinosis2.14582568
17MP0004087_abnormal_muscle_fiber2.14084525
18MP0001346_abnormal_lacrimal_gland2.14057061
19MP0010234_abnormal_vibrissa_follicle2.12999502
20MP0005623_abnormal_meninges_morphology2.08870601
21MP0000537_abnormal_urethra_morphology2.06636144
22MP0003283_abnormal_digestive_organ2.05899854
23MP0003566_abnormal_cell_adhesion1.90497717
24MP0010630_abnormal_cardiac_muscle1.89583585
25MP0000750_abnormal_muscle_regeneration1.86651289
26MP0004130_abnormal_muscle_cell1.83421081
27MP0004084_abnormal_cardiac_muscle1.79739594
28MP0004185_abnormal_adipocyte_glucose1.78901701
29MP0002163_abnormal_gland_morphology1.78683544
30MP0003137_abnormal_impulse_conducting1.69198364
31MP0008260_abnormal_autophagy1.68769600
32MP0003119_abnormal_digestive_system1.63155050
33MP0000759_abnormal_skeletal_muscle1.61745251
34MP0008057_abnormal_DNA_replication1.59610571
35MP0003329_amyloid_beta_deposits1.59333323
36MP0003303_peritoneal_inflammation1.55520117
37MP0005670_abnormal_white_adipose1.51635170
38MP0004197_abnormal_fetal_growth/weight/1.50915238
39MP0005409_darkened_coat_color1.50664422
40MP0002106_abnormal_muscle_physiology1.50406271
41MP0002086_abnormal_extraembryonic_tissu1.50173056
42MP0001545_abnormal_hematopoietic_system1.49465144
43MP0005397_hematopoietic_system_phenotyp1.49465144
44MP0003567_abnormal_fetal_cardiomyocyte1.48940956
45MP0000747_muscle_weakness1.47688492
46MP0002084_abnormal_developmental_patter1.46619256
47MP0001697_abnormal_embryo_size1.45865190
48MP0009379_abnormal_foot_pigmentation1.45538100
49MP0005257_abnormal_intraocular_pressure1.44569152
50MP0003693_abnormal_embryo_hatching1.42400589
51MP0000749_muscle_degeneration1.38593374
52MP0004858_abnormal_nervous_system1.35500640
53MP0009672_abnormal_birth_weight1.33788242
54MP0009053_abnormal_anal_canal1.31943170
55MP0005666_abnormal_adipose_tissue1.31441361
56MP0002085_abnormal_embryonic_tissue1.31296264
57MP0003828_pulmonary_edema1.30871936
58MP0001672_abnormal_embryogenesis/_devel1.30585457
59MP0005380_embryogenesis_phenotype1.30585457
60MP0000681_abnormal_thyroid_gland1.29342479
61MP0000733_abnormal_muscle_development1.28013701
62MP0001730_embryonic_growth_arrest1.26354468
63MP0008775_abnormal_heart_ventricle1.25500236
64MP0003453_abnormal_keratinocyte_physiol1.25098933
65MP0000858_altered_metastatic_potential1.24615145
66MP0004957_abnormal_blastocyst_morpholog1.24327306
67MP0003221_abnormal_cardiomyocyte_apopto1.23425528
68MP0002282_abnormal_trachea_morphology1.23397937
69MP0003984_embryonic_growth_retardation1.21149482
70MP0002088_abnormal_embryonic_growth/wei1.19094036
71MP0005369_muscle_phenotype1.16895940
72MP0002796_impaired_skin_barrier1.16074328
73MP0005171_absent_coat_pigmentation1.15186414
74MP0005058_abnormal_lysosome_morphology1.14155795
75MP0003942_abnormal_urinary_system1.13020465
76MP0002080_prenatal_lethality1.12018807
77MP0003077_abnormal_cell_cycle1.11897455
78MP0005375_adipose_tissue_phenotype1.11873809
79MP0010307_abnormal_tumor_latency1.10145423
80MP0002249_abnormal_larynx_morphology1.07071554
81MP0008932_abnormal_embryonic_tissue1.06229335
82MP0004859_abnormal_synaptic_plasticity1.05381345
83MP0000266_abnormal_heart_morphology1.05356141
84MP0004145_abnormal_muscle_electrophysio1.05331012
85MP0001188_hyperpigmentation1.04672869
86MP0004133_heterotaxia1.03887575
87MP0003656_abnormal_erythrocyte_physiolo1.03735958
88MP0001849_ear_inflammation1.03147257
89MP0005023_abnormal_wound_healing1.02345518
90MP0003111_abnormal_nucleus_morphology1.02021937
91MP0008961_abnormal_basal_metabolism1.01780837
92MP0003172_abnormal_lysosome_physiology0.98609701
93MP0008770_decreased_survivor_rate0.98157260
94MP0003385_abnormal_body_wall0.98006302
95MP0005385_cardiovascular_system_phenoty0.96748885
96MP0001544_abnormal_cardiovascular_syste0.96748885
97MP0008438_abnormal_cutaneous_collagen0.93325871
98MP0000350_abnormal_cell_proliferation0.93180831
99MP0009840_abnormal_foam_cell0.92549410
100MP0009115_abnormal_fat_cell0.91550938
101MP0003045_fibrosis0.89976938
102MP0002089_abnormal_postnatal_growth/wei0.89475113
103MP0002332_abnormal_exercise_endurance0.89325954
104MP0003634_abnormal_glial_cell0.89047034
105MP0004272_abnormal_basement_membrane0.88413903
106MP0004036_abnormal_muscle_relaxation0.88409601
107MP0005501_abnormal_skin_physiology0.87700328
108MP0008995_early_reproductive_senescence0.87322805
109MP0000313_abnormal_cell_death0.87147440
110MP0000534_abnormal_ureter_morphology0.86734530
111MP0003091_abnormal_cell_migration0.86085321
112MP0002925_abnormal_cardiovascular_devel0.85928795
113MP0004510_myositis0.85816391
114MP0000003_abnormal_adipose_tissue0.85228067
115MP0002970_abnormal_white_adipose0.84973280
116MP0009333_abnormal_splenocyte_physiolog0.84898340
117MP0004215_abnormal_myocardial_fiber0.83815760
118MP0001348_abnormal_lacrimal_gland0.83777126
119MP0000343_altered_response_to0.82841543
120MP0002111_abnormal_tail_morphology0.82298437
121MP0003191_abnormal_cellular_cholesterol0.81432810
122MP0002932_abnormal_joint_morphology0.79914706
123MP0005621_abnormal_cell_physiology0.79906175
124MP0000428_abnormal_craniofacial_morphol0.79649599
125MP0008007_abnormal_cellular_replicative0.79576248
126MP0003279_aneurysm0.75337004
127MP0003935_abnormal_craniofacial_develop0.74715887
128MP0003315_abnormal_perineum_morphology0.74619530
129MP0002060_abnormal_skin_morphology0.73937551
130MP0001784_abnormal_fluid_regulation0.73712324
131MP0003300_gastrointestinal_ulcer0.72735488
132MP0002108_abnormal_muscle_morphology0.72671705
133MP0003075_altered_response_to0.72246028
134MP0001661_extended_life_span0.72086477
135MP0000490_abnormal_crypts_of0.71087311
136MP0004808_abnormal_hematopoietic_stem0.67533586
137MP0003879_abnormal_hair_cell0.66741605
138MP0009250_abnormal_appendicular_skeleto0.66569356
139MP0001727_abnormal_embryo_implantation0.65094568
140MP0004811_abnormal_neuron_physiology0.64109622
141MP0005384_cellular_phenotype0.63689720
142MP0002114_abnormal_axial_skeleton0.63177669
143MP0000579_abnormal_nail_morphology0.62589126
144MP0006138_congestive_heart_failure0.61200279
145MP0008874_decreased_physiological_sensi0.58983996
146MP0000762_abnormal_tongue_morphology0.58915876
147MP0001270_distended_abdomen0.57041773

Predicted human phenotypes

RankGene SetZ-score
1Annular pancreas (HP:0001734)4.03716644
2Cerebral aneurysm (HP:0004944)3.82686789
3Sudden death (HP:0001699)3.70880297
4Turricephaly (HP:0000262)3.66761440
5Ulnar bowing (HP:0003031)3.63995025
6Concave nail (HP:0001598)3.48533840
7Asymmetric septal hypertrophy (HP:0001670)3.46096412
8Hypercortisolism (HP:0001578)3.30379354
9Exercise-induced myalgia (HP:0003738)3.28752793
10Difficulty climbing stairs (HP:0003551)3.15447497
11Rib fusion (HP:0000902)3.12744206
12Broad distal phalanx of finger (HP:0009836)3.10505149
13Abnormality of the lower motor neuron (HP:0002366)3.08491813
14Achilles tendon contracture (HP:0001771)3.05363779
15Distal lower limb amyotrophy (HP:0008944)3.05252164
16Exercise-induced muscle cramps (HP:0003710)2.94578885
17Myoglobinuria (HP:0002913)2.86355736
18Abnormality of the Achilles tendon (HP:0005109)2.83791521
19Vertebral compression fractures (HP:0002953)2.82833595
20Hyperthyroidism (HP:0000836)2.81096289
21Increased connective tissue (HP:0009025)2.76923332
22Alopecia of scalp (HP:0002293)2.68515160
23Aplasia/Hypoplasia of the sacrum (HP:0008517)2.67595175
24Myopathic facies (HP:0002058)2.66950257
25Distal lower limb muscle weakness (HP:0009053)2.66626918
26Centrally nucleated skeletal muscle fibers (HP:0003687)2.65217693
27Ventricular tachycardia (HP:0004756)2.63283336
28Progressive muscle weakness (HP:0003323)2.63249133
29Muscle fibrillation (HP:0010546)2.59872272
30Truncus arteriosus (HP:0001660)2.59812294
31Hyporeflexia of lower limbs (HP:0002600)2.55833781
32Hyperparathyroidism (HP:0000843)2.54894119
33Polycythemia (HP:0001901)2.54109427
34Diaphragmatic weakness (HP:0009113)2.52495315
35Coronal craniosynostosis (HP:0004440)2.50971544
36Pustule (HP:0200039)2.48789881
37Abnormality of the distal phalanges of the toes (HP:0010182)2.48033296
38Congenital hip dislocation (HP:0001374)2.47911299
39Hyperacusis (HP:0010780)2.47167446
40Long palpebral fissure (HP:0000637)2.46005104
41Male infertility (HP:0003251)2.43111784
42Lower limb amyotrophy (HP:0007210)2.41966922
43Short humerus (HP:0005792)2.41664770
44Upper limb amyotrophy (HP:0009129)2.41522254
45Distal upper limb amyotrophy (HP:0007149)2.41522254
46Abnormal hemoglobin (HP:0011902)2.38199577
47Difficulty running (HP:0009046)2.37139517
48Protrusio acetabuli (HP:0003179)2.36857169
49Ragged-red muscle fibers (HP:0003200)2.34168560
50Deep palmar crease (HP:0006191)2.31921379
51Abnormality of the phalanges of the hallux (HP:0010057)2.31056033
52Aplasia/hypoplasia of the humerus (HP:0006507)2.30548944
53Disproportionate tall stature (HP:0001519)2.27736933
54Bundle branch block (HP:0011710)2.27699385
55Abnormal gallbladder physiology (HP:0012438)2.26195340
56Cholecystitis (HP:0001082)2.26195340
57Muscle fiber splitting (HP:0003555)2.25008471
58Hamartoma of the eye (HP:0010568)2.24634389
59Vertebral hypoplasia (HP:0008417)2.24066440
60Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.24066440
61Trismus (HP:0000211)2.23942598
62Facial hemangioma (HP:0000329)2.21787756
63Stridor (HP:0010307)2.21706470
64Tongue fasciculations (HP:0001308)2.20201580
65Abnormality of the umbilical cord (HP:0010881)2.18753670
66Adenoma sebaceum (HP:0009720)2.18588490
67Angiofibromas (HP:0010615)2.18588490
68Abnormality of the aortic arch (HP:0012303)2.17539018
69Multiple lipomas (HP:0001012)2.16672419
70Genu recurvatum (HP:0002816)2.15345454
71Bowed forearm bones (HP:0003956)2.14455636
72Bowing of the arm (HP:0006488)2.14455636
73EMG: neuropathic changes (HP:0003445)2.14441675
74Abnormality of the astrocytes (HP:0100707)2.13019581
75Astrocytoma (HP:0009592)2.13019581
76Abnormality of the fetal cardiovascular system (HP:0010948)2.12728080
77Abnormal umbilical cord blood vessels (HP:0011403)2.12728080
78Single umbilical artery (HP:0001195)2.12728080
79Shallow orbits (HP:0000586)2.12305472
80Poikiloderma (HP:0001029)2.12059732
81Dysmetric saccades (HP:0000641)2.10354002
82Myotonia (HP:0002486)2.08823424
83Cutaneous melanoma (HP:0012056)2.08443481
84Patellar dislocation (HP:0002999)2.08332307
85Orthostatic hypotension (HP:0001278)2.08169856
86Selective tooth agenesis (HP:0001592)2.07354485
87Supranuclear gaze palsy (HP:0000605)2.07040927
88Hand muscle atrophy (HP:0009130)2.06735234
89Overriding aorta (HP:0002623)2.06484025
90Spinal rigidity (HP:0003306)2.06029300
91Generalized amyotrophy (HP:0003700)2.05497249
92Increased variability in muscle fiber diameter (HP:0003557)2.04587191
93Mucopolysacchariduria (HP:0008155)2.03446906
94Urinary glycosaminoglycan excretion (HP:0003541)2.03446906
95Septate vagina (HP:0001153)2.03203224
96Rectal fistula (HP:0100590)2.02442129
97Rectovaginal fistula (HP:0000143)2.02442129
98Hamartoma (HP:0010566)2.02423959
99Right ventricular cardiomyopathy (HP:0011663)2.02229053
100Lymphangioma (HP:0100764)2.01837004
101Fragile skin (HP:0001030)2.01616920
102Axonal loss (HP:0003447)2.01269094
103Basal cell carcinoma (HP:0002671)1.98613942
104Growth hormone excess (HP:0000845)1.98076452
105Abnormality of skeletal muscle fiber size (HP:0012084)1.97769007
106Reticulocytosis (HP:0001923)1.97589265
107Large for gestational age (HP:0001520)1.96060379
108Depression (HP:0000716)1.95729452
109Abnormality of the distal phalanx of the thumb (HP:0009617)1.95257630
110Cerebral inclusion bodies (HP:0100314)1.94280246
111Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.94107257
112Fasciculations (HP:0002380)1.93942155
113Abnormality of the tricuspid valve (HP:0001702)1.93222030
114Short nail (HP:0001799)1.92677330
115Vaginal fistula (HP:0004320)1.92450430
116Elfin facies (HP:0004428)1.90215514
117Pointed chin (HP:0000307)1.89124405
118Fibroma (HP:0010614)1.88915562
119Hypertensive crisis (HP:0100735)1.88849969
120Insomnia (HP:0100785)1.88023310
121Aneurysm (HP:0002617)1.87191211
122Spinal cord compression (HP:0002176)1.86921341
123Ventricular fibrillation (HP:0001663)1.86371787
124Intestinal fistula (HP:0100819)1.86207410
125Unilateral renal agenesis (HP:0000122)1.85536442
126Elbow flexion contracture (HP:0002987)1.84068106
127Testicular atrophy (HP:0000029)1.83630277
128Renal duplication (HP:0000075)1.83052835
129Abnormal large intestine physiology (HP:0012700)1.82742455
130Ependymoma (HP:0002888)1.82648584
131Mitral regurgitation (HP:0001653)1.82205795
132Hypercalcemia (HP:0003072)1.82003633
133Bowel incontinence (HP:0002607)1.81730673
134Obstructive sleep apnea (HP:0002870)1.81569018
135Round ear (HP:0100830)1.80402547
136Multiple enchondromatosis (HP:0005701)1.79991767
137Ventricular arrhythmia (HP:0004308)1.79499744
138Premature rupture of membranes (HP:0001788)1.79098933
139Vertebral fusion (HP:0002948)1.77986733
140Dysostosis multiplex (HP:0000943)1.77962894
141Abnormal ventriculo-arterial connection (HP:0011563)1.77685819
142Transposition of the great arteries (HP:0001669)1.77685819
143Abnormal connection of the cardiac segments (HP:0011545)1.77685819
144Mildly elevated creatine phosphokinase (HP:0008180)1.77344107
145Foot dorsiflexor weakness (HP:0009027)1.76862132
146EMG: myopathic abnormalities (HP:0003458)1.76834585
147Choanal stenosis (HP:0000452)1.76721840
148Short chin (HP:0000331)1.76355052
149Atrioventricular block (HP:0001678)1.76107020
150Breast hypoplasia (HP:0003187)1.74601569
151Bulbar palsy (HP:0001283)1.74409229
152Rhabdomyolysis (HP:0003201)1.73559556
153Back pain (HP:0003418)1.72789816
154Limb-girdle muscle atrophy (HP:0003797)1.72770444
155Abnormal atrioventricular conduction (HP:0005150)1.71381155
156Ankle clonus (HP:0011448)1.71140257
157Type 1 muscle fiber predominance (HP:0003803)1.70929345
158Abnormality of reticulocytes (HP:0004312)1.70188050
159Congenital glaucoma (HP:0001087)1.70020000
160Nuclear cataract (HP:0100018)1.69444379
161Visual hallucinations (HP:0002367)1.68484823
162Microretrognathia (HP:0000308)1.65158177
163Abnormality of the gallbladder (HP:0005264)1.63261418
164Broad face (HP:0000283)1.61791855
165Cholelithiasis (HP:0001081)1.61470953
166Neuronal loss in central nervous system (HP:0002529)1.61225224
167Hallux valgus (HP:0001822)1.60815133
168Congenital malformation of the right heart (HP:0011723)1.58633745
169Double outlet right ventricle (HP:0001719)1.58633745
170Deviation of the hallux (HP:0010051)1.58045415

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.72620447
2TRIB34.33873914
3DDR23.41493886
4SMG13.39934414
5IRAK33.28350818
6PRPF4B3.27881529
7PKN22.96555036
8MAP3K112.77383791
9ARAF2.60830266
10MAP3K102.48052015
11BMX2.45699676
12TYRO32.44565204
13PDGFRA2.26475329
14MAP3K62.19710198
15TTN2.04140324
16LATS22.01029898
17PINK11.80363032
18EEF2K1.78735173
19TLK11.75396464
20BRAF1.73342147
21UHMK11.68760985
22PHKG11.65817350
23PHKG21.65817350
24DYRK1B1.65761232
25MATK1.62973264
26PRKD21.60841959
27NEK11.56567541
28MAP2K31.55233674
29FGR1.49989634
30MAPK151.49318649
31DAPK11.45259288
32TAOK11.41864079
33PIM21.38417633
34RIPK11.35919254
35MAP3K131.33797631
36EPHA21.33351624
37ERN11.24917208
38PRKD31.24594342
39CSK1.23978311
40ALK1.20658553
41DMPK1.20113526
42IRAK21.12528070
43CDK121.12289872
44MAP3K91.11065786
45RPS6KC11.09976930
46RPS6KL11.09976930
47ILK1.08364890
48CDC42BPA0.99965343
49DAPK30.96223280
50PDK40.94719690
51PDK30.94719690
52TESK10.94624716
53CDK60.93354661
54MTOR0.93277941
55BRSK10.93236300
56MAP3K10.92925644
57RPS6KA60.92666025
58STK380.92243873
59TESK20.90013830
60PAK60.87644434
61PDPK10.86461835
62AURKA0.84831319
63MAPK110.84767034
64LRRK20.82206571
65LMTK20.82025508
66MOS0.82010864
67CDK70.79983563
68PIM10.77104821
69PTK60.76627505
70RPS6KA10.75223762
71KSR20.75118708
72MAPKAPK30.75016354
73SCYL20.74448847
74CDK80.73791300
75TRPM70.69675198
76TAOK20.68475923
77MAPK120.68119389
78PRKG20.67726669
79VRK20.66308793
80PAK40.66307293
81MAP3K70.64239036
82ABL20.63719654
83KDR0.63153657
84NEK20.62941038
85CAMK1D0.61515806
86BUB10.60968839
87PRKD10.60949706
88PAK20.59333879
89MAP3K30.58680798
90PTK20.58143179
91GSK3A0.57572615
92PRKAA10.57542362
93MST1R0.57109633
94RIPK40.54750204
95CHEK20.53651856
96SIK10.52431709
97RPS6KB20.52275180
98STK40.52094750
99IRAK40.50707399
100CAMKK10.49870210
101MAP3K80.49040520
102GRK60.48746576
103HIPK20.45016702
104PAK10.43932864
105SIK20.43373085
106PDK10.42111849
107PDGFRB0.40799926
108NME20.40781932
109FGFR40.40624120
110AKT20.40020559
111EPHB20.38967470
112BCKDK0.38759970
113CDK150.37000814
114CDK40.36623761
115CDK11A0.36356437
116LIMK10.36147427
117EIF2AK10.35949903
118CAMK2G0.35618292
119CAMK1G0.34846020
120MARK20.34143358
121NTRK10.33885436
122PRKCI0.33618646
123RPS6KA20.33125700
124TBK10.32183062
125RAF10.31891589
126EGFR0.31365287
127CDK20.31360929
128CDK140.30100449
129CDK180.28578278
130FLT30.27520464
131STK110.27203814
132MAP2K20.27005595
133CAMK40.26349205
134STK100.26133238
135RET0.25785458

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.36897274
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.23308977
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.62554990
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.28503314
5mTOR signaling pathway_Homo sapiens_hsa041502.25439359
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.08439565
7Biosynthesis of amino acids_Homo sapiens_hsa012302.00494373
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.93785456
9Bladder cancer_Homo sapiens_hsa052191.92888588
10Vitamin B6 metabolism_Homo sapiens_hsa007501.91173895
11Prion diseases_Homo sapiens_hsa050201.86158969
12Synaptic vesicle cycle_Homo sapiens_hsa047211.77956185
13VEGF signaling pathway_Homo sapiens_hsa043701.74770638
14Sulfur relay system_Homo sapiens_hsa041221.73716866
15Base excision repair_Homo sapiens_hsa034101.67440210
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58432433
17Hippo signaling pathway_Homo sapiens_hsa043901.54787623
18Central carbon metabolism in cancer_Homo sapiens_hsa052301.53500665
19Arginine biosynthesis_Homo sapiens_hsa002201.52754109
20Chronic myeloid leukemia_Homo sapiens_hsa052201.52664463
21Carbon metabolism_Homo sapiens_hsa012001.50547615
22Notch signaling pathway_Homo sapiens_hsa043301.49875553
23Vibrio cholerae infection_Homo sapiens_hsa051101.48736034
24Longevity regulating pathway - mammal_Homo sapiens_hsa042111.43552049
25Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.43459258
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43446998
27Other glycan degradation_Homo sapiens_hsa005111.36461042
28Insulin signaling pathway_Homo sapiens_hsa049101.36436133
29Hedgehog signaling pathway_Homo sapiens_hsa043401.35841310
30Cardiac muscle contraction_Homo sapiens_hsa042601.34884020
31Adherens junction_Homo sapiens_hsa045201.34519165
32Mismatch repair_Homo sapiens_hsa034301.33472777
33Fatty acid metabolism_Homo sapiens_hsa012121.29754320
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29596032
35mRNA surveillance pathway_Homo sapiens_hsa030151.28262185
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26284087
37Fructose and mannose metabolism_Homo sapiens_hsa000511.24471753
38Dilated cardiomyopathy_Homo sapiens_hsa054141.24056063
39Lysine degradation_Homo sapiens_hsa003101.20454361
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20210804
41Proteoglycans in cancer_Homo sapiens_hsa052051.16515871
42Viral myocarditis_Homo sapiens_hsa054161.15454213
43AMPK signaling pathway_Homo sapiens_hsa041521.12805176
44Glioma_Homo sapiens_hsa052141.12633324
45DNA replication_Homo sapiens_hsa030301.12371202
46Acute myeloid leukemia_Homo sapiens_hsa052211.11395739
47Long-term potentiation_Homo sapiens_hsa047201.07525150
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05718174
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05626353
50Focal adhesion_Homo sapiens_hsa045101.03934606
51Endometrial cancer_Homo sapiens_hsa052131.02645461
52HIF-1 signaling pathway_Homo sapiens_hsa040661.00485382
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99653457
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99337956
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99103993
56Arginine and proline metabolism_Homo sapiens_hsa003300.99101751
57Tight junction_Homo sapiens_hsa045300.98765646
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96980148
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95932440
60Non-small cell lung cancer_Homo sapiens_hsa052230.94993479
61Basal cell carcinoma_Homo sapiens_hsa052170.94674344
62Gap junction_Homo sapiens_hsa045400.92239774
63Estrogen signaling pathway_Homo sapiens_hsa049150.91950932
64Thyroid cancer_Homo sapiens_hsa052160.91567074
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89876775
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89836290
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88983330
68Shigellosis_Homo sapiens_hsa051310.88821019
69Glucagon signaling pathway_Homo sapiens_hsa049220.87749741
70Dorso-ventral axis formation_Homo sapiens_hsa043200.87629430
71Oocyte meiosis_Homo sapiens_hsa041140.84610464
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84110931
73Colorectal cancer_Homo sapiens_hsa052100.83346709
74Galactose metabolism_Homo sapiens_hsa000520.83276665
75ErbB signaling pathway_Homo sapiens_hsa040120.82546569
76Nitrogen metabolism_Homo sapiens_hsa009100.82386733
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82006685
78MicroRNAs in cancer_Homo sapiens_hsa052060.81544250
79Small cell lung cancer_Homo sapiens_hsa052220.81394207
80Apoptosis_Homo sapiens_hsa042100.80709458
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.80446327
82RNA transport_Homo sapiens_hsa030130.78730282
83Wnt signaling pathway_Homo sapiens_hsa043100.74611842
84Alcoholism_Homo sapiens_hsa050340.72581582
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.71588734
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71432561
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.70866810
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70288423
89Endocytosis_Homo sapiens_hsa041440.70262630
90Cell cycle_Homo sapiens_hsa041100.69973952
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.69262019
92Pyruvate metabolism_Homo sapiens_hsa006200.68682725
93GnRH signaling pathway_Homo sapiens_hsa049120.66390307
94Pyrimidine metabolism_Homo sapiens_hsa002400.65802980
95Insulin resistance_Homo sapiens_hsa049310.65088541
96Salmonella infection_Homo sapiens_hsa051320.64459029
97Melanoma_Homo sapiens_hsa052180.62870118
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62324068
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61141764
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.60899037
101TGF-beta signaling pathway_Homo sapiens_hsa043500.60613317
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59990792
103Viral carcinogenesis_Homo sapiens_hsa052030.57362808
104Hepatitis B_Homo sapiens_hsa051610.56319787
105Spliceosome_Homo sapiens_hsa030400.55594129
106p53 signaling pathway_Homo sapiens_hsa041150.55365223
107Renal cell carcinoma_Homo sapiens_hsa052110.55180018
108Prostate cancer_Homo sapiens_hsa052150.54429917
109Choline metabolism in cancer_Homo sapiens_hsa052310.52725456
110Lysosome_Homo sapiens_hsa041420.52239446
111Inositol phosphate metabolism_Homo sapiens_hsa005620.52237403
112Ribosome_Homo sapiens_hsa030100.50471033
113MAPK signaling pathway_Homo sapiens_hsa040100.49747111
114Pentose phosphate pathway_Homo sapiens_hsa000300.49589363
115Folate biosynthesis_Homo sapiens_hsa007900.49144322
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49083211
117Fatty acid degradation_Homo sapiens_hsa000710.48321190
118HTLV-I infection_Homo sapiens_hsa051660.47947197
119Pancreatic cancer_Homo sapiens_hsa052120.47675913
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47577875
121Melanogenesis_Homo sapiens_hsa049160.47485494
122Amoebiasis_Homo sapiens_hsa051460.46473854
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45223874
124One carbon pool by folate_Homo sapiens_hsa006700.44419319
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44366962
126Hepatitis C_Homo sapiens_hsa051600.43538454
127N-Glycan biosynthesis_Homo sapiens_hsa005100.43275341
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42862927
129B cell receptor signaling pathway_Homo sapiens_hsa046620.42679325
130Oxytocin signaling pathway_Homo sapiens_hsa049210.42462418
131Rap1 signaling pathway_Homo sapiens_hsa040150.42202856
132Epstein-Barr virus infection_Homo sapiens_hsa051690.41991052
133Prolactin signaling pathway_Homo sapiens_hsa049170.40454717
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39326147

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