UBE2L5P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.69665731
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.21580548
3platelet dense granule organization (GO:0060155)4.13025914
4ATP synthesis coupled proton transport (GO:0015986)4.10789290
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.10789290
6response to pheromone (GO:0019236)4.10767021
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.96265404
8protein complex biogenesis (GO:0070271)3.92071420
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.82918437
10mitochondrial respiratory chain complex I assembly (GO:0032981)3.82918437
11NADH dehydrogenase complex assembly (GO:0010257)3.82918437
12epithelial cilium movement (GO:0003351)3.80183594
13establishment of protein localization to mitochondrial membrane (GO:0090151)3.79224511
14piRNA metabolic process (GO:0034587)3.66398865
15L-fucose catabolic process (GO:0042355)3.56409246
16fucose catabolic process (GO:0019317)3.56409246
17L-fucose metabolic process (GO:0042354)3.56409246
18mitochondrial respiratory chain complex assembly (GO:0033108)3.53890629
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.53474645
20cellular ketone body metabolic process (GO:0046950)3.39171699
21nonmotile primary cilium assembly (GO:0035058)3.38161201
22DNA deamination (GO:0045006)3.33205617
23sperm motility (GO:0030317)3.25081834
24sequestering of actin monomers (GO:0042989)3.24654848
25multicellular organism reproduction (GO:0032504)3.21618048
26synaptic transmission, cholinergic (GO:0007271)3.21305358
27cilium movement (GO:0003341)3.16889683
28electron transport chain (GO:0022900)3.16843207
29negative regulation of telomere maintenance (GO:0032205)3.16183505
30RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.14271920
31tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.14271920
32regulation of cilium movement (GO:0003352)3.13124478
33detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.10539125
34neuron fate determination (GO:0048664)3.10219713
35ketone body metabolic process (GO:1902224)3.06878125
36indolalkylamine metabolic process (GO:0006586)3.05651976
37respiratory electron transport chain (GO:0022904)3.05497537
38protein neddylation (GO:0045116)3.03274064
39axoneme assembly (GO:0035082)3.03076800
40male meiosis (GO:0007140)2.99732219
41tryptophan catabolic process (GO:0006569)2.96394871
42indole-containing compound catabolic process (GO:0042436)2.96394871
43indolalkylamine catabolic process (GO:0046218)2.96394871
44regulation of action potential (GO:0098900)2.96334925
45acrosome reaction (GO:0007340)2.95633412
46DNA methylation involved in gamete generation (GO:0043046)2.94268830
47detection of light stimulus involved in visual perception (GO:0050908)2.94016282
48detection of light stimulus involved in sensory perception (GO:0050962)2.94016282
49axonemal dynein complex assembly (GO:0070286)2.93965653
50protein-cofactor linkage (GO:0018065)2.93266264
51protein polyglutamylation (GO:0018095)2.88754504
52tryptophan metabolic process (GO:0006568)2.87522913
53ubiquinone biosynthetic process (GO:0006744)2.86498599
54water-soluble vitamin biosynthetic process (GO:0042364)2.84550234
55respiratory chain complex IV assembly (GO:0008535)2.83848235
56hydrogen ion transmembrane transport (GO:1902600)2.80823904
57neuronal action potential (GO:0019228)2.76256708
58proton transport (GO:0015992)2.73507940
59cytochrome complex assembly (GO:0017004)2.68895989
60hydrogen transport (GO:0006818)2.67545141
61primary amino compound metabolic process (GO:1901160)2.62776964
62presynaptic membrane assembly (GO:0097105)2.61655474
63behavioral response to ethanol (GO:0048149)2.61515309
64kynurenine metabolic process (GO:0070189)2.61161563
65cilium organization (GO:0044782)2.60839528
66intracellular protein transmembrane import (GO:0044743)2.60779096
67regulation of microtubule-based movement (GO:0060632)2.59958736
68retinal cone cell development (GO:0046549)2.59943680
69ATP biosynthetic process (GO:0006754)2.58452363
70ubiquinone metabolic process (GO:0006743)2.55756457
71pseudouridine synthesis (GO:0001522)2.54961580
72regulation of rhodopsin mediated signaling pathway (GO:0022400)2.54627970
73DNA double-strand break processing (GO:0000729)2.53565510
74G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.52159784
75sulfation (GO:0051923)2.51958418
76neural tube formation (GO:0001841)2.51801109
77limb bud formation (GO:0060174)2.50913491
78spermatid development (GO:0007286)2.50767561
79cilium morphogenesis (GO:0060271)2.50475276
80cilium assembly (GO:0042384)2.49080745
81gamma-aminobutyric acid transport (GO:0015812)2.48247825
82cilium or flagellum-dependent cell motility (GO:0001539)2.46669195
83purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.46602900
84photoreceptor cell development (GO:0042461)2.46317041
85nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.45734856
86rhodopsin mediated signaling pathway (GO:0016056)2.44054764
87purine nucleoside triphosphate biosynthetic process (GO:0009145)2.43967459
88negative regulation of transcription regulatory region DNA binding (GO:2000678)2.43589152
89somite development (GO:0061053)2.43205085
90negative regulation of synaptic transmission, GABAergic (GO:0032229)2.43046684
91positive regulation of oligodendrocyte differentiation (GO:0048714)2.41956698
92otic vesicle formation (GO:0030916)2.41115319
93indole-containing compound metabolic process (GO:0042430)2.40358038
94neuron fate specification (GO:0048665)2.39222573
95transmission of nerve impulse (GO:0019226)2.35390461
96organic cation transport (GO:0015695)2.35126813
97positive regulation of action potential (GO:0045760)2.34884821
98positive regulation of gastrulation (GO:2000543)2.34094575
99synapsis (GO:0007129)2.34016671
100protein localization to cilium (GO:0061512)2.33031963

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.11128053
2VDR_22108803_ChIP-Seq_LS180_Human3.95654127
3ZNF274_21170338_ChIP-Seq_K562_Hela3.93890182
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.57578936
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53232943
6IGF1R_20145208_ChIP-Seq_DFB_Human2.46576956
7GBX2_23144817_ChIP-Seq_PC3_Human2.35197898
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.32789232
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29629517
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.22192858
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19721707
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17880045
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.09393720
14FUS_26573619_Chip-Seq_HEK293_Human2.07725288
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06806395
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.00803547
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92925039
18P300_19829295_ChIP-Seq_ESCs_Human1.91038758
19EWS_26573619_Chip-Seq_HEK293_Human1.86639962
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.86611164
21TAF15_26573619_Chip-Seq_HEK293_Human1.86263896
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.83221512
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82592635
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79746414
25ER_23166858_ChIP-Seq_MCF-7_Human1.76008125
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71450077
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.70827161
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69345206
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69230585
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67094968
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59185587
32TP53_22573176_ChIP-Seq_HFKS_Human1.56908142
33MYC_18940864_ChIP-ChIP_HL60_Human1.54486194
34TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51977750
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51977750
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49829482
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45650540
38CBP_20019798_ChIP-Seq_JUKART_Human1.45650540
39BCAT_22108803_ChIP-Seq_LS180_Human1.42351981
40NANOG_19829295_ChIP-Seq_ESCs_Human1.41617845
41SOX2_19829295_ChIP-Seq_ESCs_Human1.41617845
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.39588776
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.38434198
44REST_21632747_ChIP-Seq_MESCs_Mouse1.37977768
45RNF2_27304074_Chip-Seq_NSC_Mouse1.37687654
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.36301304
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36061878
48ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35513326
49GATA3_21878914_ChIP-Seq_MCF-7_Human1.35064306
50IRF1_19129219_ChIP-ChIP_H3396_Human1.34411337
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.31090596
52AR_25329375_ChIP-Seq_VCAP_Human1.27682995
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24048997
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.24048997
55AR_21572438_ChIP-Seq_LNCaP_Human1.23917454
56NCOR_22424771_ChIP-Seq_293T_Human1.22945356
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22732811
58ELK1_19687146_ChIP-ChIP_HELA_Human1.21996922
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20287014
60ERA_21632823_ChIP-Seq_H3396_Human1.19103006
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.18182382
62VDR_23849224_ChIP-Seq_CD4+_Human1.17822665
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15537505
64MYC_19829295_ChIP-Seq_ESCs_Human1.15144476
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15095969
66TCF4_22108803_ChIP-Seq_LS180_Human1.13646031
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13361323
68SMAD4_21799915_ChIP-Seq_A2780_Human1.13146025
69AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12693710
70TCF4_23295773_ChIP-Seq_U87_Human1.12386228
71STAT3_23295773_ChIP-Seq_U87_Human1.12291296
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10267788
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.10212821
74EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09493653
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.09187544
76RUNX2_22187159_ChIP-Seq_PCA_Human1.08786340
77CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08595862
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08356848
79EZH2_27294783_Chip-Seq_ESCs_Mouse1.07279375
80NANOG_20526341_ChIP-Seq_ESCs_Human1.07141746
81FOXH1_21741376_ChIP-Seq_EPCs_Human1.06888091
82HOXB7_26014856_ChIP-Seq_BT474_Human1.06576635
83REST_18959480_ChIP-ChIP_MESCs_Mouse1.06407357
84SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05829650
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05811688
86TAF2_19829295_ChIP-Seq_ESCs_Human1.05618721
87JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04977497
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04349697
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04220413
90ETS1_20019798_ChIP-Seq_JURKAT_Human1.02643046
91AR_20517297_ChIP-Seq_VCAP_Human1.02477598
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.02303570
93PIAS1_25552417_ChIP-Seq_VCAP_Human0.99395232
94SMAD4_21741376_ChIP-Seq_EPCs_Human0.99296948
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98788039
96SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98449958
97JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.97638330
98JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96901344
99SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94990001
100ERG_20517297_ChIP-Seq_VCAP_Human0.94241955

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.46106413
2MP0000566_synostosis2.59178409
3MP0001968_abnormal_touch/_nociception2.49726831
4MP0002102_abnormal_ear_morphology2.29005429
5MP0005551_abnormal_eye_electrophysiolog2.28020070
6MP0005410_abnormal_fertilization2.20598075
7MP0002736_abnormal_nociception_after2.17590451
8MP0001529_abnormal_vocalization2.15934700
9MP0000569_abnormal_digit_pigmentation2.11358199
10MP0004142_abnormal_muscle_tone2.04177179
11MP0001485_abnormal_pinna_reflex1.94997532
12MP0006292_abnormal_olfactory_placode1.94526444
13MP0008877_abnormal_DNA_methylation1.94466479
14MP0005645_abnormal_hypothalamus_physiol1.93149254
15MP0009745_abnormal_behavioral_response1.90426165
16MP0003646_muscle_fatigue1.88353270
17MP0008875_abnormal_xenobiotic_pharmacok1.85224874
18MP0006072_abnormal_retinal_apoptosis1.85133178
19MP0003880_abnormal_central_pattern1.84185973
20MP0002272_abnormal_nervous_system1.84141655
21MP0001486_abnormal_startle_reflex1.81512395
22MP0002653_abnormal_ependyma_morphology1.76746028
23MP0002735_abnormal_chemical_nociception1.76342251
24MP0004885_abnormal_endolymph1.76156299
25MP0008872_abnormal_physiological_respon1.74157594
26MP0006276_abnormal_autonomic_nervous1.70125712
27MP0000631_abnormal_neuroendocrine_gland1.69506804
28MP0004742_abnormal_vestibular_system1.67485412
29MP0002837_dystrophic_cardiac_calcinosis1.67235594
30MP0004133_heterotaxia1.67023355
31MP0000372_irregular_coat_pigmentation1.65648850
32MP0005084_abnormal_gallbladder_morpholo1.64960796
33MP0002938_white_spotting1.64025977
34MP0001905_abnormal_dopamine_level1.62513546
35MP0009046_muscle_twitch1.61955021
36MP0005253_abnormal_eye_physiology1.59550248
37MP0003195_calcinosis1.56778870
38MP0005646_abnormal_pituitary_gland1.55901985
39MP0002638_abnormal_pupillary_reflex1.55876439
40MP0001501_abnormal_sleep_pattern1.49900384
41MP0001986_abnormal_taste_sensitivity1.46014031
42MP0002572_abnormal_emotion/affect_behav1.43862888
43MP0003011_delayed_dark_adaptation1.39607138
44MP0002064_seizures1.34372150
45MP0009379_abnormal_foot_pigmentation1.33762447
46MP0005174_abnormal_tail_pigmentation1.33237737
47MP0001984_abnormal_olfaction1.31698592
48MP0001970_abnormal_pain_threshold1.30123104
49MP0002876_abnormal_thyroid_physiology1.29091020
50MP0000026_abnormal_inner_ear1.28877322
51MP0002277_abnormal_respiratory_mucosa1.28646556
52MP0008789_abnormal_olfactory_epithelium1.27503249
53MP0002733_abnormal_thermal_nociception1.27336274
54MP0002067_abnormal_sensory_capabilities1.26738620
55MP0002557_abnormal_social/conspecific_i1.26122691
56MP0010386_abnormal_urinary_bladder1.25397726
57MP0002928_abnormal_bile_duct1.24413772
58MP0002163_abnormal_gland_morphology1.23691116
59MP0004147_increased_porphyrin_level1.22022984
60MP0003787_abnormal_imprinting1.22009861
61MP0004043_abnormal_pH_regulation1.16918258
62MP0003878_abnormal_ear_physiology1.16314272
63MP0005377_hearing/vestibular/ear_phenot1.16314272
64MP0003698_abnormal_male_reproductive1.14604329
65MP0003635_abnormal_synaptic_transmissio1.09976854
66MP0004924_abnormal_behavior1.06064097
67MP0005386_behavior/neurological_phenoty1.06064097
68MP0002160_abnormal_reproductive_system1.05548313
69MP0001929_abnormal_gametogenesis1.04715892
70MP0005167_abnormal_blood-brain_barrier1.02239779
71MP0004145_abnormal_muscle_electrophysio1.01988628
72MP0002095_abnormal_skin_pigmentation1.01862280
73MP0008995_early_reproductive_senescence1.01492705
74MP0001963_abnormal_hearing_physiology1.01232421
75MP0001293_anophthalmia0.97833759
76MP0002063_abnormal_learning/memory/cond0.97665284
77MP0002734_abnormal_mechanical_nocicepti0.97299672
78MP0000778_abnormal_nervous_system0.97004816
79MP0005379_endocrine/exocrine_gland_phen0.95062836
80MP0002234_abnormal_pharynx_morphology0.94987648
81MP0002752_abnormal_somatic_nervous0.92389740
82MP0000049_abnormal_middle_ear0.91777177
83MP0005389_reproductive_system_phenotype0.91283366
84MP0005195_abnormal_posterior_eye0.90097427
85MP0003718_maternal_effect0.89363939
86MP0005499_abnormal_olfactory_system0.89254311
87MP0005394_taste/olfaction_phenotype0.89254311
88MP0002184_abnormal_innervation0.88923949
89MP0005171_absent_coat_pigmentation0.88268358
90MP0001502_abnormal_circadian_rhythm0.88091202
91MP0003315_abnormal_perineum_morphology0.86948025
92MP0005187_abnormal_penis_morphology0.86705246
93MP0000427_abnormal_hair_cycle0.86548973
94MP0002210_abnormal_sex_determination0.86085037
95MP0003137_abnormal_impulse_conducting0.85952378
96MP0002822_catalepsy0.81889353
97MP0010030_abnormal_orbit_morphology0.81679135
98MP0002282_abnormal_trachea_morphology0.80771807
99MP0001440_abnormal_grooming_behavior0.80456493
100MP0002229_neurodegeneration0.76792794

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.89593209
2Type II lissencephaly (HP:0007260)3.79718112
3Molar tooth sign on MRI (HP:0002419)3.77519964
4Abnormality of midbrain morphology (HP:0002418)3.77519964
5True hermaphroditism (HP:0010459)3.56919306
6Congenital stationary night blindness (HP:0007642)3.38892789
7Pancreatic fibrosis (HP:0100732)3.22178605
8Nephronophthisis (HP:0000090)3.13177115
9Lipid accumulation in hepatocytes (HP:0006561)3.11511591
103-Methylglutaconic aciduria (HP:0003535)3.10440599
11Congenital, generalized hypertrichosis (HP:0004540)3.07986921
12Increased hepatocellular lipid droplets (HP:0006565)3.07248537
13Mitochondrial inheritance (HP:0001427)3.04712067
14Attenuation of retinal blood vessels (HP:0007843)2.97089906
15Absent/shortened dynein arms (HP:0200106)2.94641775
16Dynein arm defect of respiratory motile cilia (HP:0012255)2.94641775
17Acute necrotizing encephalopathy (HP:0006965)2.82890303
18Cerebellar dysplasia (HP:0007033)2.77776874
19Increased CSF lactate (HP:0002490)2.70717700
20Abnormal ciliary motility (HP:0012262)2.67945021
21Abnormal rod and cone electroretinograms (HP:0008323)2.67939865
22Medial flaring of the eyebrow (HP:0010747)2.65156419
23Abnormal respiratory epithelium morphology (HP:0012253)2.64106998
24Abnormal respiratory motile cilium morphology (HP:0005938)2.64106998
25Abnormality of alanine metabolism (HP:0010916)2.63865663
26Hyperalaninemia (HP:0003348)2.63865663
27Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.63865663
28Renal Fanconi syndrome (HP:0001994)2.63556278
29Abnormality of the renal medulla (HP:0100957)2.59164414
30Abnormality of the renal cortex (HP:0011035)2.58887209
31Absent rod-and cone-mediated responses on ERG (HP:0007688)2.58083570
32Acute encephalopathy (HP:0006846)2.55353015
33Abnormal mitochondria in muscle tissue (HP:0008316)2.52412161
34Hepatocellular necrosis (HP:0001404)2.51026838
35Abolished electroretinogram (ERG) (HP:0000550)2.50228870
36Progressive macrocephaly (HP:0004481)2.46554946
37Pendular nystagmus (HP:0012043)2.45917715
38Hypothermia (HP:0002045)2.45288412
39Large for gestational age (HP:0001520)2.43663771
40Concave nail (HP:0001598)2.42511778
41Polydipsia (HP:0001959)2.37154287
42Abnormal drinking behavior (HP:0030082)2.37154287
43Sclerocornea (HP:0000647)2.34956899
44Optic disc pallor (HP:0000543)2.33395797
45Retinal dysplasia (HP:0007973)2.33149066
46Bony spicule pigmentary retinopathy (HP:0007737)2.31372783
47Hepatic necrosis (HP:0002605)2.31118629
48Optic nerve hypoplasia (HP:0000609)2.30871278
49Abnormal respiratory motile cilium physiology (HP:0012261)2.30335720
50Abnormality of the labia minora (HP:0012880)2.30215050
51Male pseudohermaphroditism (HP:0000037)2.29732360
52Cystic liver disease (HP:0006706)2.28362015
53Chronic hepatic failure (HP:0100626)2.27491189
54Focal motor seizures (HP:0011153)2.23922877
55Increased corneal curvature (HP:0100692)2.21709561
56Keratoconus (HP:0000563)2.21709561
57Gait imbalance (HP:0002141)2.16482015
58Exertional dyspnea (HP:0002875)2.16265640
59Renal cortical cysts (HP:0000803)2.13704767
60Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.13196668
61Lissencephaly (HP:0001339)2.11615706
62Hyperventilation (HP:0002883)2.08969768
63Intestinal atresia (HP:0011100)2.07406201
64Inability to walk (HP:0002540)2.06913064
65Gastrointestinal atresia (HP:0002589)2.06540895
66Bilateral microphthalmos (HP:0007633)2.06525934
67Hypoplasia of the pons (HP:0012110)2.03933953
68Abnormality of the pons (HP:0007361)2.03621979
69Congenital primary aphakia (HP:0007707)2.03420328
70Oligodactyly (hands) (HP:0001180)2.02308620
71Increased intramyocellular lipid droplets (HP:0012240)2.00890193
72Septo-optic dysplasia (HP:0100842)1.99822059
73Increased serum lactate (HP:0002151)1.99537229
74Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.99528870
75Esophageal atresia (HP:0002032)1.99321316
76Abnormal biliary tract physiology (HP:0012439)1.98128065
77Bile duct proliferation (HP:0001408)1.98128065
78Abnormal number of erythroid precursors (HP:0012131)1.97352706
79Aplasia/hypoplasia of the uterus (HP:0008684)1.96721273
80Furrowed tongue (HP:0000221)1.91872854
81Chorioretinal atrophy (HP:0000533)1.90322630
82Anencephaly (HP:0002323)1.89738702
83Nephrogenic diabetes insipidus (HP:0009806)1.89715728
84Tubular atrophy (HP:0000092)1.86724161
85Vaginal atresia (HP:0000148)1.86670277
86Genital tract atresia (HP:0001827)1.85987193
87Abnormal sex determination (HP:0012244)1.85457732
88Sex reversal (HP:0012245)1.85457732
89Abnormality of renal resorption (HP:0011038)1.79842802
90Polyuria (HP:0000103)1.78295843
91Agitation (HP:0000713)1.77204597
92Abnormality of urine glucose concentration (HP:0011016)1.74708121
93Glycosuria (HP:0003076)1.74708121
94Decreased central vision (HP:0007663)1.74262545
95Increased muscle lipid content (HP:0009058)1.73802880
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.72617639
97Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71792003
98Degeneration of the lateral corticospinal tracts (HP:0002314)1.70917413
99Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.70917413
100Limb dystonia (HP:0002451)1.70744771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK13.86337145
2FRK3.27536562
3BMPR1B3.25545323
4ADRBK23.13887319
5TLK13.05841392
6ZAK2.87910048
7WNK32.83794376
8MAPK152.45728494
9WNK42.37810739
10GRK12.34289080
11CASK2.24844947
12PNCK1.99000703
13INSRR1.79587542
14MAP4K21.77914873
15MAPK131.74553853
16TAOK31.70646157
17MARK11.69468896
18DYRK21.68597983
19FGFR21.66987047
20STK161.65985185
21TGFBR11.56658383
22NUAK11.56204509
23ACVR1B1.52821506
24MAP3K41.51349316
25VRK11.48711851
26EPHA31.45630830
27TXK1.37972410
28STK391.37683730
29MAP2K71.32160866
30OXSR11.29060377
31RPS6KA51.26807338
32TSSK61.20721798
33TNIK1.16557999
34MKNK21.14916131
35ADRBK11.11650001
36PLK41.09032855
37DAPK21.00500876
38TIE10.96935806
39PAK30.94898814
40EIF2AK30.94459443
41MUSK0.93415817
42MAP3K120.93135942
43PHKG10.91990576
44PHKG20.91990576
45VRK20.90097567
46CSNK1G20.89671041
47PRKCG0.85715952
48TEC0.84460250
49NME10.80813581
50MARK30.79375751
51BCKDK0.78261275
52CSNK1G30.76814751
53CDK80.76651482
54PRKCE0.75754253
55EPHB20.74034472
56NTRK20.69269765
57CSNK1G10.68186848
58STK38L0.67396836
59PKN10.62683824
60ITK0.61299068
61MKNK10.61087378
62CDK30.58877891
63CSNK1A1L0.58243583
64PRKCQ0.57769590
65TRIM280.57115261
66EPHA40.55282090
67PLK20.54968452
68PRKG10.54758250
69MAPKAPK50.54660265
70CAMK2A0.54109662
71NTRK30.51227515
72WEE10.50565435
73CSNK1A10.49945020
74PRKACA0.49916697
75PLK30.48864411
76NEK20.48299672
77KIT0.46210586
78OBSCN0.44546327
79PTK2B0.43463134
80KDR0.43434743
81DYRK30.41365000
82CAMKK20.40529561
83BMPR20.36153941
84TAF10.35923031
85CAMK10.34968149
86PRKCA0.34665863
87PASK0.34498128
88WNK10.34403467
89IKBKB0.34097879
90LIMK10.32071278
91ERBB30.31082083
92DAPK30.29352032
93GRK70.28489418
94SYK0.28265957
95MYLK0.27262391
96GRK50.27150152
97PRKCI0.26767301
98MINK10.26597759
99TNK20.25403809
100ABL10.25143958

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.68482916
2Parkinsons disease_Homo sapiens_hsa050123.15117110
3Ribosome_Homo sapiens_hsa030102.72983001
4Nitrogen metabolism_Homo sapiens_hsa009102.69201949
5Phototransduction_Homo sapiens_hsa047442.68261522
6Linoleic acid metabolism_Homo sapiens_hsa005912.37754901
7Protein export_Homo sapiens_hsa030602.36749845
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.20239532
9Nicotine addiction_Homo sapiens_hsa050332.18350017
10Huntingtons disease_Homo sapiens_hsa050162.18047053
11RNA polymerase_Homo sapiens_hsa030202.14943863
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06862187
13Cardiac muscle contraction_Homo sapiens_hsa042602.00365965
14Butanoate metabolism_Homo sapiens_hsa006501.96683978
15Alzheimers disease_Homo sapiens_hsa050101.95370987
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.93554138
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.77894368
18Proteasome_Homo sapiens_hsa030501.77233444
19Basal transcription factors_Homo sapiens_hsa030221.75645293
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70063107
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.61129413
22Caffeine metabolism_Homo sapiens_hsa002321.58925695
23Asthma_Homo sapiens_hsa053101.54911604
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53812512
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.53679793
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.51164599
27Ether lipid metabolism_Homo sapiens_hsa005651.50880356
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45730161
29Olfactory transduction_Homo sapiens_hsa047401.42825222
30Homologous recombination_Homo sapiens_hsa034401.38590443
31Propanoate metabolism_Homo sapiens_hsa006401.23862015
32Tryptophan metabolism_Homo sapiens_hsa003801.22611839
33Taste transduction_Homo sapiens_hsa047421.21227171
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11362521
35Fanconi anemia pathway_Homo sapiens_hsa034601.09898476
36Morphine addiction_Homo sapiens_hsa050321.07924693
37RNA degradation_Homo sapiens_hsa030181.05921438
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04439519
39Sulfur metabolism_Homo sapiens_hsa009201.03746997
40Selenocompound metabolism_Homo sapiens_hsa004501.03118811
41Hedgehog signaling pathway_Homo sapiens_hsa043401.01814041
42Chemical carcinogenesis_Homo sapiens_hsa052040.97488235
43Autoimmune thyroid disease_Homo sapiens_hsa053200.95887157
44Arachidonic acid metabolism_Homo sapiens_hsa005900.95499410
45Serotonergic synapse_Homo sapiens_hsa047260.94947746
46Allograft rejection_Homo sapiens_hsa053300.93733746
47Collecting duct acid secretion_Homo sapiens_hsa049660.93081488
48Type I diabetes mellitus_Homo sapiens_hsa049400.89806365
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.86223701
50GABAergic synapse_Homo sapiens_hsa047270.84762008
51Peroxisome_Homo sapiens_hsa041460.83943432
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83335547
53Glutamatergic synapse_Homo sapiens_hsa047240.82787856
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80846593
55Purine metabolism_Homo sapiens_hsa002300.80271933
56Graft-versus-host disease_Homo sapiens_hsa053320.80041318
57Insulin secretion_Homo sapiens_hsa049110.78778087
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77805281
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77122307
60Primary immunodeficiency_Homo sapiens_hsa053400.75158089
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73915494
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68641723
63Regulation of autophagy_Homo sapiens_hsa041400.67875109
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.66867968
65Circadian entrainment_Homo sapiens_hsa047130.65733349
66Basal cell carcinoma_Homo sapiens_hsa052170.64581145
67Mineral absorption_Homo sapiens_hsa049780.63958591
68Sulfur relay system_Homo sapiens_hsa041220.63948362
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63095582
70Metabolic pathways_Homo sapiens_hsa011000.62998031
71beta-Alanine metabolism_Homo sapiens_hsa004100.62455576
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61700281
73Fat digestion and absorption_Homo sapiens_hsa049750.61218474
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60952141
75One carbon pool by folate_Homo sapiens_hsa006700.60931220
76Retinol metabolism_Homo sapiens_hsa008300.59687053
77Ovarian steroidogenesis_Homo sapiens_hsa049130.58754351
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58374518
79Systemic lupus erythematosus_Homo sapiens_hsa053220.57496449
80Pyrimidine metabolism_Homo sapiens_hsa002400.57439757
81ABC transporters_Homo sapiens_hsa020100.57141296
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54673549
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53091832
84Glycerolipid metabolism_Homo sapiens_hsa005610.52625832
85Calcium signaling pathway_Homo sapiens_hsa040200.50962955
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50667954
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50377836
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.49879848
89Cocaine addiction_Homo sapiens_hsa050300.49008113
90Rheumatoid arthritis_Homo sapiens_hsa053230.48172440
91Salivary secretion_Homo sapiens_hsa049700.46774005
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46463952
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44591498
94Histidine metabolism_Homo sapiens_hsa003400.42930647
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39352722
96Synaptic vesicle cycle_Homo sapiens_hsa047210.38574222
97Dorso-ventral axis formation_Homo sapiens_hsa043200.35396390
98Antigen processing and presentation_Homo sapiens_hsa046120.34699946
99Amphetamine addiction_Homo sapiens_hsa050310.33532107
100RNA transport_Homo sapiens_hsa030130.32675378

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