UBE2L4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1activated T cell proliferation (GO:0050798)5.39125896
2signal peptide processing (GO:0006465)5.32526225
3ubiquinone biosynthetic process (GO:0006744)5.24474861
4behavioral response to nicotine (GO:0035095)5.03960109
5ubiquinone metabolic process (GO:0006743)4.57805217
6protein heterotetramerization (GO:0051290)4.38596471
7quinone biosynthetic process (GO:1901663)4.34705480
8transcription from RNA polymerase I promoter (GO:0006360)4.34621828
9protein polyglutamylation (GO:0018095)4.16049407
10regulation of protein glycosylation (GO:0060049)4.13017814
11negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)4.06705514
12positive regulation of glycoprotein biosynthetic process (GO:0010560)4.01156124
13RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.98210756
14tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.98210756
15cell proliferation in forebrain (GO:0021846)3.81460451
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.80598253
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.77650693
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.77650693
19NADH dehydrogenase complex assembly (GO:0010257)3.77650693
20ribosomal small subunit assembly (GO:0000028)3.77313188
21isoprenoid biosynthetic process (GO:0008299)3.76298768
22regulation of regulatory T cell differentiation (GO:0045589)3.69990202
23negative regulation of neurotransmitter secretion (GO:0046929)3.69087131
24DNA double-strand break processing (GO:0000729)3.62874846
25regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.62164217
26regulation of immunoglobulin secretion (GO:0051023)3.61934184
27regulation of cilium movement (GO:0003352)3.57312786
28protein complex biogenesis (GO:0070271)3.47278325
29transcription elongation from RNA polymerase I promoter (GO:0006362)3.47108722
30regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.46671858
31regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.46671858
32DNA deamination (GO:0045006)3.40058324
33protein-cofactor linkage (GO:0018065)3.39208959
34ncRNA 3-end processing (GO:0043628)3.33578605
35regulation of isotype switching to IgG isotypes (GO:0048302)3.31742363
36substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.30419480
37substrate-independent telencephalic tangential migration (GO:0021826)3.30419480
38peptidyl-histidine modification (GO:0018202)3.30226421
39positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.28552436
40peristalsis (GO:0030432)3.26231394
41GTP biosynthetic process (GO:0006183)3.18150426
42mitochondrial respiratory chain complex assembly (GO:0033108)3.16344235
43termination of RNA polymerase I transcription (GO:0006363)3.15514900
44phasic smooth muscle contraction (GO:0014821)3.12064630
45leukotriene biosynthetic process (GO:0019370)3.08594396
46motile cilium assembly (GO:0044458)3.07784794
47detection of light stimulus involved in visual perception (GO:0050908)3.01389184
48detection of light stimulus involved in sensory perception (GO:0050962)3.01389184
49meiotic chromosome segregation (GO:0045132)2.98454370
50positive regulation of transcription regulatory region DNA binding (GO:2000679)2.95915556
51detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.94409994
52mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.93492021
53heterotypic cell-cell adhesion (GO:0034113)2.90809892
54autophagic vacuole fusion (GO:0000046)2.87900829
55mannose metabolic process (GO:0006013)2.87377795
56mannosylation (GO:0097502)2.86036845
57maturation of 5.8S rRNA (GO:0000460)2.85427010
58dopamine transport (GO:0015872)2.84862338
59regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.84726480
60synaptic transmission, cholinergic (GO:0007271)2.83309929
61phosphatidylinositol acyl-chain remodeling (GO:0036149)2.73954548
62chaperone-mediated protein transport (GO:0072321)2.73071852
63cellular anion homeostasis (GO:0030002)2.73006249
64epithelial cilium movement (GO:0003351)2.69454600
65positive regulation of glycoprotein metabolic process (GO:1903020)2.69127237
66negative regulation of neurotransmitter transport (GO:0051589)2.64198029
67cytokine biosynthetic process (GO:0042089)2.61567838
68regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.61552318
69nonmotile primary cilium assembly (GO:0035058)2.60051464
70regulation of interleukin-6 biosynthetic process (GO:0045408)2.59965811
71membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.58348948
72regulation of neurotransmitter uptake (GO:0051580)2.57869959
73diacylglycerol metabolic process (GO:0046339)2.57843730
74UTP metabolic process (GO:0046051)2.56610163
75UTP biosynthetic process (GO:0006228)2.56525003
76positive regulation of organelle assembly (GO:1902117)2.55707974
77magnesium ion transport (GO:0015693)2.54747115
78multicellular organism reproduction (GO:0032504)2.54067082
79negative regulation of glycogen biosynthetic process (GO:0045719)2.54065098
80establishment of protein localization to mitochondrial membrane (GO:0090151)2.50797990
81energy coupled proton transport, down electrochemical gradient (GO:0015985)2.49755280
82ATP synthesis coupled proton transport (GO:0015986)2.49755280
83transcription initiation from RNA polymerase I promoter (GO:0006361)2.47144000
84rRNA catabolic process (GO:0016075)2.46786685
85electron transport chain (GO:0022900)2.46094294
86xenobiotic catabolic process (GO:0042178)2.45968503
87respiratory electron transport chain (GO:0022904)2.45039136
88ketone biosynthetic process (GO:0042181)2.43874669
89regulation of interleukin-8 secretion (GO:2000482)2.42778836
90detection of mechanical stimulus involved in sensory perception (GO:0050974)2.41897707
91negative regulation of execution phase of apoptosis (GO:1900118)2.41463873
92smooth muscle contraction (GO:0006939)2.41013314
93amine catabolic process (GO:0009310)2.39523774
94cellular biogenic amine catabolic process (GO:0042402)2.39523774
95pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.39048235
96regulation of microtubule-based movement (GO:0060632)2.38133039
97head development (GO:0060322)2.38110991
98positive regulation of cAMP-mediated signaling (GO:0043950)2.35382337
99cytidine deamination (GO:0009972)2.33909496
100cytidine catabolic process (GO:0006216)2.33909496

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.56962995
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.31513074
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.88413129
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.46042534
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.02823705
6VDR_22108803_ChIP-Seq_LS180_Human2.88984006
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.62906876
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.56959814
9ZNF274_21170338_ChIP-Seq_K562_Hela2.54680376
10PCGF2_27294783_Chip-Seq_NPCs_Mouse2.40599236
11EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.39981689
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.37038545
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.28905865
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.23041664
15EZH2_22144423_ChIP-Seq_EOC_Human2.21868180
16EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.16127655
17IGF1R_20145208_ChIP-Seq_DFB_Human2.12910436
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.11542294
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01637164
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.93016874
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86738721
22NFE2_27457419_Chip-Seq_LIVER_Mouse1.76552844
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76263163
24SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64014318
25EWS_26573619_Chip-Seq_HEK293_Human1.63302454
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.62243035
27EZH2_27294783_Chip-Seq_NPCs_Mouse1.55681255
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.55490147
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54904522
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54728290
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54499140
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53764075
33TP53_22573176_ChIP-Seq_HFKS_Human1.52448197
34GATA1_22025678_ChIP-Seq_K562_Human1.52085554
35VDR_23849224_ChIP-Seq_CD4+_Human1.51225650
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46244059
37PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.44784493
38STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.43032513
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42568651
40CBP_20019798_ChIP-Seq_JUKART_Human1.42568651
41PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.38686873
42ELK1_19687146_ChIP-ChIP_HELA_Human1.37401786
43RUNX_20019798_ChIP-Seq_JUKART_Human1.34940311
44CRX_20693478_ChIP-Seq_RETINA_Mouse1.33156168
45IRF1_19129219_ChIP-ChIP_H3396_Human1.26677750
46SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.25817493
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.24246440
48BCAT_22108803_ChIP-Seq_LS180_Human1.24224682
49ER_23166858_ChIP-Seq_MCF-7_Human1.23572354
50TAF15_26573619_Chip-Seq_HEK293_Human1.22738730
51ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21705168
52GATA3_26560356_Chip-Seq_TH2_Human1.21056277
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21008636
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17559671
55GBX2_23144817_ChIP-Seq_PC3_Human1.16535956
56SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15470514
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15459957
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.13865184
59P300_19829295_ChIP-Seq_ESCs_Human1.13527594
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12551555
61OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12303877
62CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10002538
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07484679
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.07214531
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05500087
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.05500087
67HOXB7_26014856_ChIP-Seq_BT474_Human1.03835022
68P53_22387025_ChIP-Seq_ESCs_Mouse1.03026334
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02934834
70TAF2_19829295_ChIP-Seq_ESCs_Human1.02015978
71FLI1_21867929_ChIP-Seq_TH2_Mouse1.01797901
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01202298
73P53_21459846_ChIP-Seq_SAOS-2_Human1.00869242
74STAT3_18555785_Chip-Seq_ESCs_Mouse1.00867177
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.00600200
76FOXH1_21741376_ChIP-Seq_EPCs_Human0.98917921
77EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98625882
78NANOG_19829295_ChIP-Seq_ESCs_Human0.98291384
79SOX2_19829295_ChIP-Seq_ESCs_Human0.98291384
80CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97548545
81RUNX1_27457419_Chip-Seq_LIVER_Mouse0.97073857
82MYC_19829295_ChIP-Seq_ESCs_Human0.95480854
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95462754
84E2F1_18555785_Chip-Seq_ESCs_Mouse0.95290610
85REST_21632747_ChIP-Seq_MESCs_Mouse0.94930276
86JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94678123
87AR_20517297_ChIP-Seq_VCAP_Human0.94328075
88FUS_26573619_Chip-Seq_HEK293_Human0.93867076
89FOXP3_21729870_ChIP-Seq_TREG_Human0.92823642
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92480058
91SOX2_18555785_Chip-Seq_ESCs_Mouse0.92406510
92RUNX2_22187159_ChIP-Seq_PCA_Human0.91481078
93CTCF_18555785_Chip-Seq_ESCs_Mouse0.90702857
94SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90305019
95AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90084437
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89789406
97CREB1_15753290_ChIP-ChIP_HEK293T_Human0.89543725
98P300_18555785_Chip-Seq_ESCs_Mouse0.89495777
99EED_16625203_ChIP-ChIP_MESCs_Mouse0.88995145
100NMYC_18555785_Chip-Seq_ESCs_Mouse0.88958869

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.43809063
2MP0010386_abnormal_urinary_bladder4.19114663
3MP0002138_abnormal_hepatobiliary_system3.11447331
4MP0008877_abnormal_DNA_methylation2.74196687
5MP0005084_abnormal_gallbladder_morpholo2.48201393
6MP0002837_dystrophic_cardiac_calcinosis2.48014661
7MP0003724_increased_susceptibility_to2.42893063
8MP0008875_abnormal_xenobiotic_pharmacok2.39623279
9MP0002933_joint_inflammation2.38653928
10MP0004147_increased_porphyrin_level2.38171418
11MP0002102_abnormal_ear_morphology2.36079739
12MP0002653_abnormal_ependyma_morphology2.28610830
13MP0008872_abnormal_physiological_respon2.21046473
14MP0001529_abnormal_vocalization2.16070240
15MP0003787_abnormal_imprinting2.06320256
16MP0003011_delayed_dark_adaptation2.05348097
17MP0001919_abnormal_reproductive_system2.03884881
18MP0002876_abnormal_thyroid_physiology1.98882270
19MP0005671_abnormal_response_to1.91707122
20MP0001905_abnormal_dopamine_level1.81142908
21MP0005083_abnormal_biliary_tract1.81066752
22MP0003195_calcinosis1.79002025
23MP0005253_abnormal_eye_physiology1.76480976
24MP0006292_abnormal_olfactory_placode1.72035157
25MP0005360_urolithiasis1.71302051
26MP0000538_abnormal_urinary_bladder1.70631105
27MP0004142_abnormal_muscle_tone1.68771752
28MP0006276_abnormal_autonomic_nervous1.68095232
29MP0005645_abnormal_hypothalamus_physiol1.62319037
30MP0004885_abnormal_endolymph1.58793235
31MP0001968_abnormal_touch/_nociception1.58079069
32MP0003123_paternal_imprinting1.56215601
33MP0005389_reproductive_system_phenotype1.55523645
34MP0006072_abnormal_retinal_apoptosis1.51660303
35MP0003646_muscle_fatigue1.50290352
36MP0004145_abnormal_muscle_electrophysio1.48305132
37MP0001835_abnormal_antigen_presentation1.44731594
38MP0001485_abnormal_pinna_reflex1.36863489
39MP0005670_abnormal_white_adipose1.34005239
40MP0002638_abnormal_pupillary_reflex1.31841116
41MP0005408_hypopigmentation1.30985195
42MP0003315_abnormal_perineum_morphology1.25853868
43MP0002736_abnormal_nociception_after1.24495974
44MP0008789_abnormal_olfactory_epithelium1.18242581
45MP0002277_abnormal_respiratory_mucosa1.17461577
46MP0005646_abnormal_pituitary_gland1.16084921
47MP0005551_abnormal_eye_electrophysiolog1.14871534
48MP0009046_muscle_twitch1.14188000
49MP0005387_immune_system_phenotype1.11266073
50MP0001790_abnormal_immune_system1.11266073
51MP0001800_abnormal_humoral_immune1.10671461
52MP0000230_abnormal_systemic_arterial1.09458681
53MP0005000_abnormal_immune_tolerance1.07055741
54MP0009745_abnormal_behavioral_response1.04946687
55MP0003763_abnormal_thymus_physiology1.04113382
56MP0002272_abnormal_nervous_system1.02585571
57MP0001502_abnormal_circadian_rhythm1.02127600
58MP0002148_abnormal_hypersensitivity_rea1.01854196
59MP0004924_abnormal_behavior1.00555927
60MP0005386_behavior/neurological_phenoty1.00555927
61MP0003866_abnormal_defecation0.99913231
62MP0002160_abnormal_reproductive_system0.95886846
63MP0001970_abnormal_pain_threshold0.93322879
64MP0000372_irregular_coat_pigmentation0.92589972
65MP0000631_abnormal_neuroendocrine_gland0.90448718
66MP0002909_abnormal_adrenal_gland0.90199741
67MP0000613_abnormal_salivary_gland0.89727634
68MP0001191_abnormal_skin_condition0.89147667
69MP0000465_gastrointestinal_hemorrhage0.85172836
70MP0000604_amyloidosis0.84445840
71MP0002557_abnormal_social/conspecific_i0.83071361
72MP0003121_genomic_imprinting0.82245121
73MP0009785_altered_susceptibility_to0.81718900
74MP0002405_respiratory_system_inflammati0.81360928
75MP0006082_CNS_inflammation0.78873252
76MP0002735_abnormal_chemical_nociception0.78508841
77MP0003718_maternal_effect0.78069060
78MP0002184_abnormal_innervation0.77367282
79MP0005197_abnormal_uvea_morphology0.77224880
80MP0003937_abnormal_limbs/digits/tail_de0.77132742
81MP0002572_abnormal_emotion/affect_behav0.76576285
82MP0000778_abnormal_nervous_system0.75388877
83MP0005636_abnormal_mineral_homeostasis0.75112236
84MP0005595_abnormal_vascular_smooth0.74284279
85MP0005195_abnormal_posterior_eye0.73912818
86MP0002210_abnormal_sex_determination0.73835987
87MP0002928_abnormal_bile_duct0.73582480
88MP0002723_abnormal_immune_serum0.71519912
89MP0005187_abnormal_penis_morphology0.70224438
90MP0005391_vision/eye_phenotype0.70179545
91MP0005503_abnormal_tendon_morphology0.69153845
92MP0008775_abnormal_heart_ventricle0.69012713
93MP0004036_abnormal_muscle_relaxation0.68406729
94MP0005025_abnormal_response_to0.68232182
95MP0001986_abnormal_taste_sensitivity0.67941857
96MP0001188_hyperpigmentation0.67881690
97MP0001845_abnormal_inflammatory_respons0.67412297
98MP0008873_increased_physiological_sensi0.66639671
99MP0001873_stomach_inflammation0.65151100
100MP0002095_abnormal_skin_pigmentation0.64782759

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of midbrain morphology (HP:0002418)4.13269664
2Molar tooth sign on MRI (HP:0002419)4.13269664
3Recurrent gram-negative bacterial infections (HP:0005420)3.92016282
4Periodontitis (HP:0000704)3.83238916
5Chronic bronchitis (HP:0004469)3.79623745
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.65110625
7Azoospermia (HP:0000027)3.57440082
8Pancreatic cysts (HP:0001737)3.36130565
9Abnormality of the pons (HP:0007361)3.32694321
10Acute necrotizing encephalopathy (HP:0006965)3.31242301
11Hypoplasia of the pons (HP:0012110)3.21723198
12Aplasia/hypoplasia of the uterus (HP:0008684)3.02181505
13Mitochondrial inheritance (HP:0001427)2.98666044
14Fibular aplasia (HP:0002990)2.95837562
15Asplenia (HP:0001746)2.89063477
16Pancreatic fibrosis (HP:0100732)2.88973800
17Sparse scalp hair (HP:0002209)2.87972597
18Aplasia/Hypoplasia of the spleen (HP:0010451)2.80547501
19Acute encephalopathy (HP:0006846)2.79407329
20Abnormal mitochondria in muscle tissue (HP:0008316)2.77664951
21Type I transferrin isoform profile (HP:0003642)2.76018505
22Progressive macrocephaly (HP:0004481)2.74284187
23Abnormal respiratory motile cilium physiology (HP:0012261)2.72000694
24Increased hepatocellular lipid droplets (HP:0006565)2.66897718
25Adactyly (HP:0009776)2.64895000
26Increased CSF lactate (HP:0002490)2.61077956
27Abnormal spermatogenesis (HP:0008669)2.56344905
28Congenital, generalized hypertrichosis (HP:0004540)2.55956157
29Leukocytosis (HP:0001974)2.55887742
30Tubular atrophy (HP:0000092)2.52628626
31Nephronophthisis (HP:0000090)2.47548415
32Microretrognathia (HP:0000308)2.44892013
33Stomatitis (HP:0010280)2.44601389
34Bony spicule pigmentary retinopathy (HP:0007737)2.43748733
35Lipid accumulation in hepatocytes (HP:0006561)2.40485120
36Abolished electroretinogram (ERG) (HP:0000550)2.40461602
37Absent/shortened dynein arms (HP:0200106)2.40094323
38Dynein arm defect of respiratory motile cilia (HP:0012255)2.40094323
39Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.39122702
40Abnormal protein N-linked glycosylation (HP:0012347)2.39122702
41Abnormal protein glycosylation (HP:0012346)2.39122702
42Abnormal glycosylation (HP:0012345)2.39122702
43Partial duplication of thumb phalanx (HP:0009944)2.37475311
44Optic disc pallor (HP:0000543)2.35017543
45Exertional dyspnea (HP:0002875)2.28168752
46Radial bowing (HP:0002986)2.26235021
47Anencephaly (HP:0002323)2.22183229
48Rhinitis (HP:0012384)2.21991995
49Hypothermia (HP:0002045)2.21961349
50Abnormality of the renal medulla (HP:0100957)2.20862829
51Absent thumb (HP:0009777)2.20514497
523-Methylglutaconic aciduria (HP:0003535)2.20474596
53Hypoproteinemia (HP:0003075)2.19711955
54Congenital stationary night blindness (HP:0007642)2.17074725
55Cystic liver disease (HP:0006706)2.11644651
56Renal Fanconi syndrome (HP:0001994)2.08148557
57IgG deficiency (HP:0004315)2.07392667
58True hermaphroditism (HP:0010459)2.05360698
59Constricted visual fields (HP:0001133)2.04886102
60Cerebellar dysplasia (HP:0007033)2.04062839
61Hypoalbuminemia (HP:0003073)2.03846499
62Abnormal albumin level (HP:0012116)2.03846499
63Decreased circulating renin level (HP:0003351)2.03103217
64Abnormal ciliary motility (HP:0012262)2.02338872
65Proximal tubulopathy (HP:0000114)2.01152420
66Decreased activity of mitochondrial respiratory chain (HP:0008972)1.99445682
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.99445682
68Delayed CNS myelination (HP:0002188)1.98277913
69Hepatocellular necrosis (HP:0001404)1.98225738
70Partial duplication of the phalanx of hand (HP:0009999)1.97548573
71Abnormal delayed hypersensitivity skin test (HP:0002963)1.97516431
72Progressive cerebellar ataxia (HP:0002073)1.97270596
73Abnormal respiratory motile cilium morphology (HP:0005938)1.97013716
74Abnormal respiratory epithelium morphology (HP:0012253)1.97013716
75Facial shape deformation (HP:0011334)1.96703839
76Potter facies (HP:0002009)1.96703839
77Type II lissencephaly (HP:0007260)1.92955397
78Autoimmune hemolytic anemia (HP:0001890)1.90977530
79Attenuation of retinal blood vessels (HP:0007843)1.90828186
80Humeroradial synostosis (HP:0003041)1.90325088
81Synostosis involving the elbow (HP:0003938)1.90325088
82Nonimmune hydrops fetalis (HP:0001790)1.89660366
83Hypoplastic pelvis (HP:0008839)1.89511469
84Polydipsia (HP:0001959)1.89163819
85Abnormal drinking behavior (HP:0030082)1.89163819
86Alveolar cell carcinoma (HP:0006519)1.88316211
87Abnormality of the axillary hair (HP:0100134)1.87396911
88Abnormality of secondary sexual hair (HP:0009888)1.87396911
89Prostate neoplasm (HP:0100787)1.86182051
90Hypoplasia of the radius (HP:0002984)1.85775362
91Rectal fistula (HP:0100590)1.84627942
92Rectovaginal fistula (HP:0000143)1.84627942
93Hypoplasia of the uterus (HP:0000013)1.84224111
94Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83886957
95Abnormality of the renal cortex (HP:0011035)1.83668030
96Cerebral edema (HP:0002181)1.83611331
97Amelogenesis imperfecta (HP:0000705)1.82473747
98Increased serum lactate (HP:0002151)1.82226190
99Abnormality of DNA repair (HP:0003254)1.80770637
100Squamous cell carcinoma (HP:0002860)1.80002149

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK13.84217470
2PRKCH3.72878652
3TXK3.02713369
4MAP2K72.68411402
5TNK22.65263360
6ZAK2.64233415
7MAP4K22.55276769
8PBK2.45457279
9CDK82.42921384
10TLK12.20869970
11STK162.20734487
12PLK22.13759661
13NUAK12.08232540
14NEK22.07347363
15WNK42.06035909
16PLK41.95216728
17ADRBK21.92648799
18MAPK131.90746991
19FRK1.75577399
20TAOK31.72449708
21DYRK21.68849099
22TNIK1.58263899
23WNK31.56163140
24MUSK1.52272007
25TYRO31.47873794
26MST41.42514961
27NME21.37730587
28STK391.28664755
29FES1.25549991
30GRK11.23705105
31ICK1.21510799
32PINK11.10756089
33ACVR1B1.10539036
34PRKCQ1.09665513
35MAP4K11.05021802
36CSK1.03268082
37ADRBK11.01303525
38DAPK20.97536774
39AURKA0.95403084
40PHKG20.94956523
41PHKG10.94956523
42PRKCG0.89654748
43LCK0.89341012
44BMPR1B0.88556049
45BUB10.81767305
46RPS6KB10.78021041
47PDK20.76257157
48VRK20.75388579
49PKN10.73203216
50MAP2K60.72858228
51VRK10.72808850
52MARK10.72571958
53DAPK10.71355343
54WEE10.71116951
55EPHA30.67235570
56PRKCI0.66861468
57INSRR0.65437427
58CAMK2A0.65177846
59TEC0.64236892
60SYK0.63229021
61OXSR10.62646870
62TIE10.62168111
63WNK10.61660305
64RPS6KA20.60988765
65PIK3CA0.60951880
66CAMK2D0.59601163
67CSNK1A10.59024690
68EIF2AK20.58585377
69CAMK10.57918684
70BMPR20.57666345
71MAP3K40.56680659
72RPS6KA60.56291863
73SGK10.55172378
74PRKCD0.52763168
75IKBKB0.51427323
76ABL20.48858480
77RPS6KL10.47886781
78RPS6KC10.47886781
79PRKCE0.47513696
80FER0.45259901
81PRKACA0.44850353
82CAMK40.43555962
83PRKCB0.42628013
84SRPK10.42565773
85CSNK2A20.42237860
86MAPK40.41263215
87TYK20.40959492
88PLK10.40375440
89CSNK1E0.39145293
90BCKDK0.38614751
91CAMK2G0.37752153
92OBSCN0.37298152
93IRAK20.34790863
94PRKCA0.34696612
95MAP3K140.34503926
96PRKD20.31962783
97GSK3A0.30493828
98KIT0.30394888
99MAP2K10.29168736
100CSF1R0.27842696

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030203.90544887
2Oxidative phosphorylation_Homo sapiens_hsa001903.00560410
3Caffeine metabolism_Homo sapiens_hsa002322.98300511
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.88478215
5Parkinsons disease_Homo sapiens_hsa050122.73837472
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.50706596
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.26487922
8Linoleic acid metabolism_Homo sapiens_hsa005912.23903666
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.17365475
10Ribosome_Homo sapiens_hsa030102.13420614
11Nitrogen metabolism_Homo sapiens_hsa009102.10144073
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.06101025
13Proteasome_Homo sapiens_hsa030501.75279545
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.72871000
15Huntingtons disease_Homo sapiens_hsa050161.71734042
16Basal transcription factors_Homo sapiens_hsa030221.69508371
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.67751005
18Autoimmune thyroid disease_Homo sapiens_hsa053201.66590685
19Alzheimers disease_Homo sapiens_hsa050101.57541197
20Propanoate metabolism_Homo sapiens_hsa006401.46615675
21Allograft rejection_Homo sapiens_hsa053301.46264519
22Graft-versus-host disease_Homo sapiens_hsa053321.45133033
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.45121735
24Cardiac muscle contraction_Homo sapiens_hsa042601.44989530
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43780707
26Fat digestion and absorption_Homo sapiens_hsa049751.43641383
27Rheumatoid arthritis_Homo sapiens_hsa053231.42492632
28Phototransduction_Homo sapiens_hsa047441.42111532
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41799009
30Type I diabetes mellitus_Homo sapiens_hsa049401.37777994
31Primary immunodeficiency_Homo sapiens_hsa053401.35553063
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.32491017
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.26357293
34Tryptophan metabolism_Homo sapiens_hsa003801.25647556
35RNA degradation_Homo sapiens_hsa030181.25061912
36Protein export_Homo sapiens_hsa030601.19233105
37Pyrimidine metabolism_Homo sapiens_hsa002401.17801894
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17708686
39Nicotine addiction_Homo sapiens_hsa050331.15650797
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15614885
41Arachidonic acid metabolism_Homo sapiens_hsa005901.13758777
42Glutathione metabolism_Homo sapiens_hsa004801.11343538
43Fanconi anemia pathway_Homo sapiens_hsa034601.10210932
44Glycerolipid metabolism_Homo sapiens_hsa005611.10032388
45Homologous recombination_Homo sapiens_hsa034401.09756519
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08872288
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06965562
48Mineral absorption_Homo sapiens_hsa049781.04693991
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04674238
50Ether lipid metabolism_Homo sapiens_hsa005651.03286183
51Malaria_Homo sapiens_hsa051441.02635949
52Morphine addiction_Homo sapiens_hsa050321.01910194
53Asthma_Homo sapiens_hsa053100.97111961
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96415627
55Chemical carcinogenesis_Homo sapiens_hsa052040.94269052
56Olfactory transduction_Homo sapiens_hsa047400.91976061
57Nucleotide excision repair_Homo sapiens_hsa034200.91768559
58Staphylococcus aureus infection_Homo sapiens_hsa051500.90469376
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.79469478
60Purine metabolism_Homo sapiens_hsa002300.79307111
61Taste transduction_Homo sapiens_hsa047420.75508315
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71472948
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70942610
64Retinol metabolism_Homo sapiens_hsa008300.70438635
65Hedgehog signaling pathway_Homo sapiens_hsa043400.68633123
66T cell receptor signaling pathway_Homo sapiens_hsa046600.67784212
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.66501605
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66254348
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65500922
70Hematopoietic cell lineage_Homo sapiens_hsa046400.64780985
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.63465616
72Legionellosis_Homo sapiens_hsa051340.63145773
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63016107
74Spliceosome_Homo sapiens_hsa030400.61637248
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.61455073
76Viral myocarditis_Homo sapiens_hsa054160.59945114
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57501855
78RNA transport_Homo sapiens_hsa030130.56423703
79Fatty acid degradation_Homo sapiens_hsa000710.52986155
80Metabolic pathways_Homo sapiens_hsa011000.52004890
81Butanoate metabolism_Homo sapiens_hsa006500.51852903
82Serotonergic synapse_Homo sapiens_hsa047260.50659380
83Basal cell carcinoma_Homo sapiens_hsa052170.48987352
84Fatty acid biosynthesis_Homo sapiens_hsa000610.48705015
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.47235683
86Peroxisome_Homo sapiens_hsa041460.47025074
87Insulin secretion_Homo sapiens_hsa049110.45987293
88Leishmaniasis_Homo sapiens_hsa051400.44380415
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42429986
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40958842
91beta-Alanine metabolism_Homo sapiens_hsa004100.40655356
92Collecting duct acid secretion_Homo sapiens_hsa049660.40430613
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39893870
94Salivary secretion_Homo sapiens_hsa049700.34770000
95Synaptic vesicle cycle_Homo sapiens_hsa047210.34225163
96Measles_Homo sapiens_hsa051620.32421622
97Pertussis_Homo sapiens_hsa051330.29381156
98Cholinergic synapse_Homo sapiens_hsa047250.26596311
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25712094
100GABAergic synapse_Homo sapiens_hsa047270.25129569

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »