UBE2L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of macrophage activation (GO:0043032)9.24478447
2regulation of interleukin-5 production (GO:0032674)7.27364856
3regulation of gonadotropin secretion (GO:0032276)7.09619391
4cellular response to follicle-stimulating hormone stimulus (GO:0071372)6.37421119
5negative regulation of macrophage differentiation (GO:0045650)6.34505196
6endocrine hormone secretion (GO:0060986)5.47437056
7positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.37389119
8negative regulation of interferon-gamma production (GO:0032689)5.37233016
9regulation of endothelial cell differentiation (GO:0045601)5.33541117
10regulation of T-helper 1 type immune response (GO:0002825)5.06291795
11response to follicle-stimulating hormone (GO:0032354)4.90026742
12regulation of macrophage differentiation (GO:0045649)4.86818526
13regulation of macrophage activation (GO:0043030)4.79099449
14regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.54889912
15DNA deamination (GO:0045006)4.41224571
16regulation of B cell differentiation (GO:0045577)4.29551041
17cellular response to sterol (GO:0036315)4.29520656
18regulation of regulatory T cell differentiation (GO:0045589)4.27924151
19cellular response to cholesterol (GO:0071397)4.18575506
20cytidine deamination (GO:0009972)4.06408350
21cytidine metabolic process (GO:0046087)4.06408350
22cytidine catabolic process (GO:0006216)4.06408350
23positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.05295277
24positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.05295277
25positive regulation of mitotic sister chromatid separation (GO:1901970)4.05295277
26regulation of isotype switching to IgG isotypes (GO:0048302)4.03120397
27positive regulation of actin filament depolymerization (GO:0030836)3.99653611
28eosinophil chemotaxis (GO:0048245)3.83481888
29positive regulation of macrophage differentiation (GO:0045651)3.79410039
30negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.74178139
31positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)3.70743145
32positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)3.62059581
33eyelid development in camera-type eye (GO:0061029)3.60049186
34regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.58172215
35negative regulation of axon extension involved in axon guidance (GO:0048843)3.56078140
36hemoglobin metabolic process (GO:0020027)3.53695471
37response to sterol (GO:0036314)3.51770119
38amine catabolic process (GO:0009310)3.49016405
39cellular biogenic amine catabolic process (GO:0042402)3.49016405
40positive regulation of tolerance induction (GO:0002645)3.48002968
41nucleotide transmembrane transport (GO:1901679)3.47963916
42cGMP-mediated signaling (GO:0019934)3.45565628
43proteasome assembly (GO:0043248)3.44521471
44negative regulation of mast cell activation (GO:0033004)3.42839533
45pyrimidine ribonucleoside catabolic process (GO:0046133)3.42797268
46regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.42789607
47eosinophil migration (GO:0072677)3.42755800
48water-soluble vitamin biosynthetic process (GO:0042364)3.39491559
49response to cholesterol (GO:0070723)3.32993191
50negative regulation of adaptive immune response (GO:0002820)3.32847175
51behavioral response to ethanol (GO:0048149)3.32138196
52cAMP catabolic process (GO:0006198)3.29119904
53negative regulation of complement activation (GO:0045916)3.27911581
54mesodermal cell differentiation (GO:0048333)3.25256814
55positive regulation of interleukin-17 production (GO:0032740)3.17131957
56cytolysis (GO:0019835)3.13268620
57regulation of T cell tolerance induction (GO:0002664)3.10648968
58cellular response to gonadotropin stimulus (GO:0071371)3.10416535
59positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.09622223
60hepatocyte apoptotic process (GO:0097284)3.08656738
61regulation of tyrosine phosphorylation of STAT protein (GO:0042509)3.06692329
62ribonucleoprotein complex disassembly (GO:0032988)2.97622729
63positive regulation of JAK-STAT cascade (GO:0046427)2.97517759
64regulation of interferon-gamma production (GO:0032649)2.95578143
65positive regulation of lymphocyte migration (GO:2000403)2.86550111
66positive regulation of erythrocyte differentiation (GO:0045648)2.86027491
67negative regulation of protein activation cascade (GO:2000258)2.84781519
68DNA integration (GO:0015074)2.82899687
69negative regulation of axon guidance (GO:1902668)2.81612449
70regulation of chronic inflammatory response (GO:0002676)2.81567904
71negative regulation by host of viral transcription (GO:0043922)2.81520540
72Arp2/3 complex-mediated actin nucleation (GO:0034314)2.79129939
73regulation of interferon-gamma biosynthetic process (GO:0045072)2.78637343
74negative regulation of B cell activation (GO:0050869)2.78537174
75regulation of tyrosine phosphorylation of Stat3 protein (GO:0042516)2.78316080
76regulation of lymphocyte chemotaxis (GO:1901623)2.75169615
77negative regulation of lymphocyte differentiation (GO:0045620)2.74420451
78regulation of relaxation of muscle (GO:1901077)2.74219284
79L-fucose catabolic process (GO:0042355)2.73713185
80fucose catabolic process (GO:0019317)2.73713185
81L-fucose metabolic process (GO:0042354)2.73713185
82cyclic nucleotide catabolic process (GO:0009214)2.71224265
83adenosine metabolic process (GO:0046085)2.67902859
84positive regulation of T cell mediated cytotoxicity (GO:0001916)2.66808961
85T cell migration (GO:0072678)2.64555146
86establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.61610008
87multicellular organism reproduction (GO:0032504)2.60557550
88signal peptide processing (GO:0006465)2.59923806
89activin receptor signaling pathway (GO:0032924)2.59502836
90actin nucleation (GO:0045010)2.56718946
91negative regulation of Ras GTPase activity (GO:0034261)2.56216972
92regulation of calcium-mediated signaling (GO:0050848)2.51229355
93regulation of cellular amino acid metabolic process (GO:0006521)2.50994565
94interferon-gamma production (GO:0032609)2.50638369
95regulation of endothelial cell chemotaxis (GO:2001026)2.50296756
96cellular response to interleukin-4 (GO:0071353)2.48655499
97positive regulation of chemokine production (GO:0032722)2.48312052
98positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.47647813
99positive regulation of chemokine secretion (GO:0090197)12.2759430
100regulation of chemokine secretion (GO:0090196)10.6113129

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.43651968
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.92641394
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.75736764
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.18935271
5ZNF274_21170338_ChIP-Seq_K562_Hela2.95081244
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.87230393
7VDR_22108803_ChIP-Seq_LS180_Human2.61141310
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.52024450
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43280699
10TAF15_26573619_Chip-Seq_HEK293_Human2.41925461
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.37984829
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.23694889
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.20543344
14GBX2_23144817_ChIP-Seq_PC3_Human2.19218519
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.04303977
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03587324
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01830820
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.99550711
19SMAD_19615063_ChIP-ChIP_OVARY_Human1.94691865
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89755322
21ER_23166858_ChIP-Seq_MCF-7_Human1.87334120
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85552725
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.82860828
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77649973
25ELK1_19687146_ChIP-ChIP_HELA_Human1.76018494
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.74423384
27SCL_19346495_ChIP-Seq_HPC-7_Human1.68419950
28BCAT_22108803_ChIP-Seq_LS180_Human1.65850270
29GATA1_22025678_ChIP-Seq_K562_Human1.65525527
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65407438
31VDR_23849224_ChIP-Seq_CD4+_Human1.63612445
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57442618
33EWS_26573619_Chip-Seq_HEK293_Human1.55363506
34CBP_20019798_ChIP-Seq_JUKART_Human1.53865960
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53865960
36TP53_22573176_ChIP-Seq_HFKS_Human1.50345780
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49964471
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.47701859
39P300_19829295_ChIP-Seq_ESCs_Human1.46316819
40CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.45794149
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44346398
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.44096962
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.42611621
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40965563
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39751627
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36810191
47SMAD4_21799915_ChIP-Seq_A2780_Human1.36637131
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33952499
49KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31243646
50GATA3_26560356_Chip-Seq_TH2_Human1.30878980
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30225026
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.26839163
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.25806026
54ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24849503
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23965855
56IGF1R_20145208_ChIP-Seq_DFB_Human1.23804302
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.18138329
58CRX_20693478_ChIP-Seq_RETINA_Mouse1.16150993
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14814206
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.14732604
61CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.14224746
62CJUN_26792858_Chip-Seq_BT549_Human1.13132601
63JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12024621
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10965118
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.10712360
66FUS_26573619_Chip-Seq_HEK293_Human1.10490221
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10233106
68AR_20517297_ChIP-Seq_VCAP_Human1.08970430
69SALL4_22934838_ChIP-ChIP_CD34+_Human1.08430937
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.07889123
71PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07846992
72GATA6_21074721_ChIP-Seq_CACO-2_Human1.07815542
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.07455917
74TCF4_22108803_ChIP-Seq_LS180_Human1.06689844
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.05986930
76STAT3_23295773_ChIP-Seq_U87_Human1.04839985
77CDX2_22108803_ChIP-Seq_LS180_Human1.04108473
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03912473
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03046728
80OCT4_18555785_Chip-Seq_ESCs_Mouse1.01291935
81PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01253340
82SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00691884
83CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00607550
84FOXP3_21729870_ChIP-Seq_TREG_Human0.99664014
85FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99396538
86FOXA1_25329375_ChIP-Seq_VCAP_Human0.99396538
87TCF4_23295773_ChIP-Seq_U87_Human0.99113375
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99067725
89PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98451937
90TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97137535
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96363472
92CTCF_18555785_Chip-Seq_ESCs_Mouse0.96163653
93NANOG_18555785_Chip-Seq_ESCs_Mouse0.95426047
94MYC_19829295_ChIP-Seq_ESCs_Human0.95325827
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95247795
96TP53_18474530_ChIP-ChIP_U2OS_Human0.95170088
97CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.94896083
98PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94608403
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94205228
100NFYB_21822215_ChIP-Seq_K562_Human0.94061803

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose6.29227312
2MP0005187_abnormal_penis_morphology5.53585377
3MP0002009_preneoplasia3.36588511
4MP0006072_abnormal_retinal_apoptosis3.33432093
5MP0003315_abnormal_perineum_morphology3.20964337
6MP0002006_tumorigenesis3.03408410
7MP0002166_altered_tumor_susceptibility3.00256022
8MP0002102_abnormal_ear_morphology2.96885907
9MP0002638_abnormal_pupillary_reflex2.93456951
10MP0005671_abnormal_response_to2.88813887
11MP0003300_gastrointestinal_ulcer2.73866390
12MP0003136_yellow_coat_color2.62161450
13MP0002148_abnormal_hypersensitivity_rea2.49356658
14MP0005253_abnormal_eye_physiology2.44700498
15MP0001835_abnormal_antigen_presentation2.37304743
16MP0005171_absent_coat_pigmentation2.35760803
17MP0009697_abnormal_copulation2.04221314
18MP0003763_abnormal_thymus_physiology1.97956503
19MP0000343_altered_response_to1.97906204
20MP0001299_abnormal_eye_distance/1.86774227
21MP0004215_abnormal_myocardial_fiber1.85342607
22MP0003806_abnormal_nucleotide_metabolis1.82469623
23MP0002837_dystrophic_cardiac_calcinosis1.79700697
24MP0003787_abnormal_imprinting1.77894752
25MP0000372_irregular_coat_pigmentation1.66567300
26MP0003183_abnormal_peptide_metabolism1.63342586
27MP0001661_extended_life_span1.53548874
28MP0005645_abnormal_hypothalamus_physiol1.52761531
29MP0009333_abnormal_splenocyte_physiolog1.44608992
30MP0003252_abnormal_bile_duct1.37567202
31MP0008877_abnormal_DNA_methylation1.37076072
32MP0003646_muscle_fatigue1.26657123
33MP0002877_abnormal_melanocyte_morpholog1.25936611
34MP0000569_abnormal_digit_pigmentation1.22708472
35MP0003045_fibrosis1.22427505
36MP0008872_abnormal_physiological_respon1.19142950
37MP0004084_abnormal_cardiac_muscle1.17146647
38MP0001502_abnormal_circadian_rhythm1.15585637
39MP0009785_altered_susceptibility_to1.12602114
40MP0003950_abnormal_plasma_membrane1.11844792
41MP0002876_abnormal_thyroid_physiology1.09970262
42MP0001984_abnormal_olfaction1.09069235
43MP0005167_abnormal_blood-brain_barrier1.05934795
44MP0005085_abnormal_gallbladder_physiolo1.05231195
45MP0005551_abnormal_eye_electrophysiolog1.03946334
46MP0000013_abnormal_adipose_tissue1.03930972
47MP0003866_abnormal_defecation1.03798484
48MP0002723_abnormal_immune_serum1.02628569
49MP0001845_abnormal_inflammatory_respons0.99815681
50MP0001800_abnormal_humoral_immune0.98182181
51MP0001853_heart_inflammation0.97777377
52MP0005083_abnormal_biliary_tract0.97084692
53MP0009745_abnormal_behavioral_response0.95753902
54MP0005391_vision/eye_phenotype0.95540115
55MP0003137_abnormal_impulse_conducting0.91567613
56MP0001905_abnormal_dopamine_level0.89201764
57MP0000230_abnormal_systemic_arterial0.85862152
58MP0002909_abnormal_adrenal_gland0.85024300
59MP0000465_gastrointestinal_hemorrhage0.84955251
60MP0003724_increased_susceptibility_to0.83694482
61MP0002405_respiratory_system_inflammati0.83571415
62MP0005408_hypopigmentation0.83445618
63MP0002420_abnormal_adaptive_immunity0.81953776
64MP0005025_abnormal_response_to0.81796546
65MP0001764_abnormal_homeostasis0.80097981
66MP0001986_abnormal_taste_sensitivity0.79615059
67MP0006082_CNS_inflammation0.79204739
68MP0002928_abnormal_bile_duct0.78897820
69MP0006292_abnormal_olfactory_placode0.76209423
70MP0003936_abnormal_reproductive_system0.75545120
71MP0001819_abnormal_immune_cell0.75445860
72MP0005000_abnormal_immune_tolerance0.75005519
73MP0005387_immune_system_phenotype0.74100138
74MP0001790_abnormal_immune_system0.74100138
75MP0003878_abnormal_ear_physiology0.73376031
76MP0005377_hearing/vestibular/ear_phenot0.73376031
77MP0002277_abnormal_respiratory_mucosa0.71239149
78MP0008789_abnormal_olfactory_epithelium0.70229805
79MP0001119_abnormal_female_reproductive0.69999035
80MP0004742_abnormal_vestibular_system0.68967574
81MP0009643_abnormal_urine_homeostasis0.68042225
82MP0005248_abnormal_Harderian_gland0.64980575
83MP0004147_increased_porphyrin_level0.64585305
84MP0002090_abnormal_vision0.64054912
85MP0002452_abnormal_antigen_presenting0.63374012
86MP0008875_abnormal_xenobiotic_pharmacok0.62878498
87MP0005174_abnormal_tail_pigmentation0.62723619
88MP0001873_stomach_inflammation0.62369920
89MP0002693_abnormal_pancreas_physiology0.61592784
90MP0001501_abnormal_sleep_pattern0.60842674
91MP0004036_abnormal_muscle_relaxation0.59587789
92MP0001881_abnormal_mammary_gland0.59552433
93MP0003448_altered_tumor_morphology0.56927899
94MP0002398_abnormal_bone_marrow0.56646338
95MP0005584_abnormal_enzyme/coenzyme_acti0.55997106
96MP0003786_premature_aging0.55616603
97MP0002168_other_aberrant_phenotype0.55559929
98MP0000716_abnormal_immune_system0.55235129
99MP0004134_abnormal_chest_morphology0.54952521
100MP0006036_abnormal_mitochondrial_physio0.53888204

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.61635218
2Absent rod-and cone-mediated responses on ERG (HP:0007688)4.41855540
3Hypoproteinemia (HP:0003075)3.88318621
4Abnormality of alanine metabolism (HP:0010916)3.83921186
5Hyperalaninemia (HP:0003348)3.83921186
6Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.83921186
7Polydipsia (HP:0001959)3.64811724
8Abnormal drinking behavior (HP:0030082)3.64811724
9Bilateral sensorineural hearing impairment (HP:0008619)3.63396646
10Tubular atrophy (HP:0000092)3.36542567
11Follicular hyperkeratosis (HP:0007502)3.15673488
12Autoimmune hemolytic anemia (HP:0001890)3.14004496
13Alopecia of scalp (HP:0002293)3.11451134
14Pancreatic fibrosis (HP:0100732)2.98512981
15Abnormal rod and cone electroretinograms (HP:0008323)2.98343006
16Abnormality of T cell number (HP:0011839)2.91861056
17Elevated erythrocyte sedimentation rate (HP:0003565)2.89608402
18T lymphocytopenia (HP:0005403)2.84116555
19Short tibia (HP:0005736)2.72040143
20Aplasia/Hypoplasia of the tibia (HP:0005772)2.71652763
21Abnormality of midbrain morphology (HP:0002418)2.70557200
22Molar tooth sign on MRI (HP:0002419)2.70557200
23Nephronophthisis (HP:0000090)2.66478052
24Pancreatic cysts (HP:0001737)2.65744293
25Dyschromatopsia (HP:0007641)2.60945866
26Median cleft lip (HP:0000161)2.58559164
27Abolished electroretinogram (ERG) (HP:0000550)2.58130886
28Hypokalemic alkalosis (HP:0001949)2.53854113
29Abnormality of the renal cortex (HP:0011035)2.53161440
30Aplasia/Hypoplasia involving the musculature (HP:0001460)2.53140946
31Severe combined immunodeficiency (HP:0004430)2.46129882
32Sensory axonal neuropathy (HP:0003390)2.41762902
33Renal cortical cysts (HP:0000803)2.38828762
34Intestinal atresia (HP:0011100)2.37485091
35Spastic paraparesis (HP:0002313)2.34999793
36Abnormality of the renal medulla (HP:0100957)2.34548041
37Oligomenorrhea (HP:0000876)2.31248351
38IgG deficiency (HP:0004315)2.30553531
39Metaphyseal dysplasia (HP:0100255)2.29841238
40Polyuria (HP:0000103)2.29818894
41Thyroiditis (HP:0100646)2.29560730
42Alkalosis (HP:0001948)2.26268993
43Abnormality of eosinophils (HP:0001879)2.25777807
44Hypothermia (HP:0002045)2.23815007
45Generalized myoclonic seizures (HP:0002123)2.20121079
46Gastrointestinal atresia (HP:0002589)2.18311169
47True hermaphroditism (HP:0010459)2.15386138
48Hypoalbuminemia (HP:0003073)2.15222171
49Abnormal albumin level (HP:0012116)2.15222171
50Chronic sinusitis (HP:0011109)2.08426522
51Autoamputation (HP:0001218)2.07793675
52Bile duct proliferation (HP:0001408)2.07273746
53Abnormal biliary tract physiology (HP:0012439)2.07273746
54Hypokinesia (HP:0002375)2.04719101
55Stomatitis (HP:0010280)2.03949239
56Tongue fasciculations (HP:0001308)2.02992952
57Aplasia/Hypoplasia of the tongue (HP:0010295)2.02448254
583-Methylglutaconic aciduria (HP:0003535)2.00297201
59Methylmalonic acidemia (HP:0002912)1.99395499
60Alveolar cell carcinoma (HP:0006519)1.99013518
61Increased CSF lactate (HP:0002490)1.98455906
62Decreased central vision (HP:0007663)1.96982987
63Chronic diarrhea (HP:0002028)1.96504571
64Facial diplegia (HP:0001349)1.95598830
65Renal Fanconi syndrome (HP:0001994)1.95443564
66Abnormality of lateral ventricle (HP:0030047)1.94232061
67Hyperkalemia (HP:0002153)1.92567485
68Eosinophilia (HP:0001880)1.91869132
69Cerebral edema (HP:0002181)1.91436777
70Papilledema (HP:0001085)1.90864231
71Bifid tongue (HP:0010297)1.90798497
72Increased hepatocellular lipid droplets (HP:0006565)1.89072913
73Lipid accumulation in hepatocytes (HP:0006561)1.88943515
74Congenital, generalized hypertrichosis (HP:0004540)1.88693449
75Submucous cleft hard palate (HP:0000176)1.88140940
76Congenital stationary night blindness (HP:0007642)1.87092401
77Microglossia (HP:0000171)1.85362811
78Chronic hepatic failure (HP:0100626)1.83298949
79Menstrual irregularities (HP:0000858)1.79740113
80Abnormal urine output (HP:0012590)1.79548432
81Abnormality of T cells (HP:0002843)1.79385532
82Congenital hepatic fibrosis (HP:0002612)1.78544312
83Abnormality of the ischium (HP:0003174)1.78059852
84Optic disc pallor (HP:0000543)1.77975158
85Asplenia (HP:0001746)1.77612554
86Pigmentary retinal degeneration (HP:0001146)1.76677792
87Constricted visual fields (HP:0001133)1.75652789
88Ectropion (HP:0000656)1.75592172
89Febrile seizures (HP:0002373)1.75315526
90Prostate neoplasm (HP:0100787)1.74716124
91Metabolic acidosis (HP:0001942)1.74003031
92Gastrointestinal infarctions (HP:0005244)1.73547649
93Abnormal mitochondria in muscle tissue (HP:0008316)1.72828491
94Mitochondrial inheritance (HP:0001427)1.72691367
95White forelock (HP:0002211)1.72665008
96Aplasia/Hypoplasia of the spleen (HP:0010451)1.72446778
97Type I diabetes mellitus (HP:0100651)1.72236313
98Hyperglycemia (HP:0003074)1.70492020
99Combined immunodeficiency (HP:0005387)1.69598779
100Acute necrotizing encephalopathy (HP:0006965)1.69550733

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CLK16.16624867
2KDR3.38434286
3TESK22.93198132
4FRK2.82524678
5BMPR22.44013948
6TXK2.42631408
7STK392.40682053
8ADRBK22.36957170
9WNK42.25669373
10PDK22.23167201
11MAP2K72.17217394
12TEC2.14156113
13STK38L2.07037161
14ACVR1B1.99725465
15AKT31.97858192
16MAP3K41.91926558
17ITK1.86469304
18PINK11.79343054
19PLK21.73395933
20TAOK31.65825429
21MAP4K11.61291810
22INSRR1.56323791
23MAP4K21.52092834
24BMPR1B1.50185887
25CDK31.43594067
26MYLK1.40390563
27OXSR11.35720392
28NEK61.29914993
29ERBB31.29033423
30PRKCQ1.26192878
31BCKDK1.25247750
32TESK11.19653223
33CSK1.09327191
34NUAK10.98753721
35GRK10.96159549
36BUB10.94469163
37SRPK10.93749017
38VRK20.90685686
39LIMK10.88873183
40OBSCN0.87399663
41NEK20.84794545
42PAK30.80159779
43MARK30.79163835
44EPHA30.77643817
45ADRBK10.77333938
46PIK3CG0.76017465
47TIE10.74134549
48MAPK130.74018054
49MAP3K120.73811492
50MAP2K60.71287355
51PRKCE0.70558487
52MAPKAPK50.70418595
53WNK30.68295814
54MAPK110.68155747
55TLK10.66716442
56IKBKE0.64315722
57BTK0.63423696
58RPS6KA50.63232049
59ROCK10.63165163
60CDK90.63001924
61IRAK20.61319426
62PAK60.60392134
63PRKCH0.59646484
64CSNK1A10.59379410
65LCK0.58993845
66IRAK10.58085503
67DYRK20.57506961
68MAPKAPK30.57458423
69TGFBR10.56434391
70VRK10.52831182
71EIF2AK30.52412158
72TNK20.51116569
73LYN0.50312540
74PIK3CA0.50001541
75LATS10.47675463
76RPS6KB10.47191910
77AURKA0.46229811
78FER0.45803733
79CDK60.44984209
80ATR0.44705221
81GRK60.43648937
82PRKCA0.42938614
83PRKACA0.42919757
84GRK50.41587621
85IRAK40.41279167
86INSR0.39992929
87CAMK2A0.39715595
88NME10.38579710
89ZAK0.37192251
90PLK30.35705737
91PKN10.35181679
92PLK10.34896588
93CAMKK20.34511373
94IKBKB0.34061973
95PHKG20.33413453
96PHKG10.33413453
97CHEK20.32884478
98SGK30.32665402
99PRKCG0.32027446
100PTK2B0.31806238

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.79479715
2Primary immunodeficiency_Homo sapiens_hsa053403.67839315
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.29648016
4Graft-versus-host disease_Homo sapiens_hsa053322.97012311
5Protein export_Homo sapiens_hsa030602.75287240
6Antigen processing and presentation_Homo sapiens_hsa046122.55807129
7Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.51756141
8Hematopoietic cell lineage_Homo sapiens_hsa046402.37342138
9Basal transcription factors_Homo sapiens_hsa030222.26565042
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.11088255
11T cell receptor signaling pathway_Homo sapiens_hsa046601.94043436
12Autoimmune thyroid disease_Homo sapiens_hsa053201.91514849
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.89292986
14Oxidative phosphorylation_Homo sapiens_hsa001901.88093403
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.88001368
16Nitrogen metabolism_Homo sapiens_hsa009101.87600339
17Allograft rejection_Homo sapiens_hsa053301.86991583
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.64135464
19Type I diabetes mellitus_Homo sapiens_hsa049401.59821128
20Rheumatoid arthritis_Homo sapiens_hsa053231.57845688
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.52823678
22Parkinsons disease_Homo sapiens_hsa050121.52700339
23Linoleic acid metabolism_Homo sapiens_hsa005911.47682393
24Butanoate metabolism_Homo sapiens_hsa006501.46658339
25Fatty acid biosynthesis_Homo sapiens_hsa000611.41547194
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33556911
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.28775868
28Selenocompound metabolism_Homo sapiens_hsa004501.25603547
29Caffeine metabolism_Homo sapiens_hsa002321.24505650
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.18754905
31Salmonella infection_Homo sapiens_hsa051321.18036204
32Collecting duct acid secretion_Homo sapiens_hsa049661.16690426
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16644570
34Asthma_Homo sapiens_hsa053101.15193615
35Propanoate metabolism_Homo sapiens_hsa006401.13998018
36Olfactory transduction_Homo sapiens_hsa047401.11688264
37Non-homologous end-joining_Homo sapiens_hsa034501.02782242
38ABC transporters_Homo sapiens_hsa020100.96043359
39Measles_Homo sapiens_hsa051620.94348192
40NF-kappa B signaling pathway_Homo sapiens_hsa040640.89669250
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89068089
42Phototransduction_Homo sapiens_hsa047440.88429305
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87131697
44TGF-beta signaling pathway_Homo sapiens_hsa043500.86726658
45Alzheimers disease_Homo sapiens_hsa050100.86658587
46Ether lipid metabolism_Homo sapiens_hsa005650.86293540
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85459398
48Chemical carcinogenesis_Homo sapiens_hsa052040.80022519
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80018210
50One carbon pool by folate_Homo sapiens_hsa006700.75908951
51Fat digestion and absorption_Homo sapiens_hsa049750.68691367
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.68654717
53Taste transduction_Homo sapiens_hsa047420.68014858
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.66235844
55Morphine addiction_Homo sapiens_hsa050320.65670149
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64263327
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62067990
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61579001
59Fanconi anemia pathway_Homo sapiens_hsa034600.61426620
60Tryptophan metabolism_Homo sapiens_hsa003800.60969878
61RNA polymerase_Homo sapiens_hsa030200.60475097
62Huntingtons disease_Homo sapiens_hsa050160.60302276
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59651997
64Regulation of autophagy_Homo sapiens_hsa041400.59381261
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57279657
66Retinol metabolism_Homo sapiens_hsa008300.54524190
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52520638
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.52026982
69Calcium signaling pathway_Homo sapiens_hsa040200.51799958
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51624208
71Lysosome_Homo sapiens_hsa041420.50617071
72Chemokine signaling pathway_Homo sapiens_hsa040620.49759193
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49529690
74Fatty acid degradation_Homo sapiens_hsa000710.49053210
75Fatty acid metabolism_Homo sapiens_hsa012120.48760384
76Vitamin digestion and absorption_Homo sapiens_hsa049770.48722954
77Arginine and proline metabolism_Homo sapiens_hsa003300.48659934
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.48587536
79Cardiac muscle contraction_Homo sapiens_hsa042600.48180062
80Purine metabolism_Homo sapiens_hsa002300.48102027
81Peroxisome_Homo sapiens_hsa041460.47321747
82Sulfur metabolism_Homo sapiens_hsa009200.47204219
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46642985
84RNA transport_Homo sapiens_hsa030130.46603668
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.46444924
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46086612
87Nicotine addiction_Homo sapiens_hsa050330.45016326
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40237109
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40164170
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39896665
91Metabolic pathways_Homo sapiens_hsa011000.39856414
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.38160151
93TNF signaling pathway_Homo sapiens_hsa046680.38007290
94Homologous recombination_Homo sapiens_hsa034400.36466458
95Pyrimidine metabolism_Homo sapiens_hsa002400.36219174
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35449434
97Circadian rhythm_Homo sapiens_hsa047100.35125710
98Hedgehog signaling pathway_Homo sapiens_hsa043400.34321435
99Renin secretion_Homo sapiens_hsa049240.33100802
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33069529

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