UBE2H

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skin morphogenesis (GO:0043589)3.56026948
2negative regulation of glycogen biosynthetic process (GO:0045719)3.39816167
3cytoskeletal anchoring at plasma membrane (GO:0007016)3.30880653
4pyrimidine nucleobase catabolic process (GO:0006208)3.30874253
5positive regulation of receptor recycling (GO:0001921)3.28903756
6negative regulation of glycogen metabolic process (GO:0070874)3.24036473
7negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.19914860
8negative regulation of fatty acid transport (GO:2000192)3.18994099
9regulation of glycogen (starch) synthase activity (GO:2000465)3.17174272
10ER overload response (GO:0006983)3.17113939
11regulation of hippo signaling (GO:0035330)3.15990851
12regulation of NFAT protein import into nucleus (GO:0051532)3.02326779
13negative regulation of stem cell proliferation (GO:2000647)3.01788482
14protein localization to endosome (GO:0036010)2.99400233
15hypotonic response (GO:0006971)2.98552882
16ganglion development (GO:0061548)2.98395040
17cell adhesion mediated by integrin (GO:0033627)2.95429571
18hemidesmosome assembly (GO:0031581)2.95307483
19lung secretory cell differentiation (GO:0061140)2.92477598
20planar cell polarity pathway involved in neural tube closure (GO:0090179)2.92468519
21outflow tract septum morphogenesis (GO:0003148)2.89837853
22regulation of relaxation of muscle (GO:1901077)2.84828601
23cell-substrate junction assembly (GO:0007044)2.83695642
24negative regulation of striated muscle cell apoptotic process (GO:0010664)2.82627735
25epithelial cell-cell adhesion (GO:0090136)2.78494225
26growth hormone receptor signaling pathway (GO:0060396)2.76431569
27regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.76327105
28regulation of cardioblast differentiation (GO:0051890)2.76047223
29positive regulation of fatty acid oxidation (GO:0046321)2.67198621
30neuron remodeling (GO:0016322)2.64753757
31neural crest cell development (GO:0014032)2.64566564
32negative regulation of dendrite morphogenesis (GO:0050774)2.62419823
33limb bud formation (GO:0060174)2.60744319
34regulation of transforming growth factor beta2 production (GO:0032909)2.59400621
35semaphorin-plexin signaling pathway (GO:0071526)2.59318446
36endodermal cell differentiation (GO:0035987)2.58700149
37regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.58651976
38positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.57556878
39establishment or maintenance of apical/basal cell polarity (GO:0035088)2.57214626
40establishment or maintenance of bipolar cell polarity (GO:0061245)2.57214626
41positive regulation of fatty acid beta-oxidation (GO:0032000)2.56845248
42regulation of early endosome to late endosome transport (GO:2000641)2.56628417
43apical protein localization (GO:0045176)2.55742574
44glial cell proliferation (GO:0014009)2.55204455
45desmosome organization (GO:0002934)2.54073124
46kidney morphogenesis (GO:0060993)2.52940308
47paraxial mesoderm development (GO:0048339)2.51688427
48regulation of cardiac muscle cell apoptotic process (GO:0010665)2.50103712
49insulin-like growth factor receptor signaling pathway (GO:0048009)2.50050347
50adherens junction assembly (GO:0034333)2.49490865
51atrioventricular valve morphogenesis (GO:0003181)2.48615052
52nucleobase catabolic process (GO:0046113)2.47389977
53import into cell (GO:0098657)2.46569954
54cellular response to growth hormone stimulus (GO:0071378)2.43422575
55cell-substrate adherens junction assembly (GO:0007045)2.43199959
56focal adhesion assembly (GO:0048041)2.43199959
57negative regulation of anoikis (GO:2000811)2.42303660
58cellular response to monoamine stimulus (GO:0071868)2.41533000
59cellular response to catecholamine stimulus (GO:0071870)2.41533000
60negative regulation of cardiac muscle hypertrophy (GO:0010614)2.40378121
61macroautophagy (GO:0016236)2.40081841
62positive regulation of p38MAPK cascade (GO:1900745)2.39261347
63regulation of glucan biosynthetic process (GO:0010962)2.38181956
64regulation of glycogen biosynthetic process (GO:0005979)2.38181956
65cell proliferation involved in kidney development (GO:0072111)2.37882731
66kidney mesenchyme development (GO:0072074)2.37772806
67positive regulation of endothelial cell differentiation (GO:0045603)2.36679747
68protein retention in ER lumen (GO:0006621)2.34694892
69morphogenesis of an epithelial sheet (GO:0002011)2.33652045
70camera-type eye morphogenesis (GO:0048593)2.33462765
71stress fiber assembly (GO:0043149)2.32653380
72cortical actin cytoskeleton organization (GO:0030866)2.32215960
73collagen fibril organization (GO:0030199)2.32085813
74cardiac septum morphogenesis (GO:0060411)2.30923998
75mesodermal cell differentiation (GO:0048333)2.30768560
76positive regulation of glycogen biosynthetic process (GO:0045725)2.30550779
77endocardial cushion development (GO:0003197)2.30353870
78peptidyl-proline hydroxylation (GO:0019511)2.30220274
79metanephric mesenchyme development (GO:0072075)2.30127036
80regulation of cardiac muscle hypertrophy (GO:0010611)2.30061163
81maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.30037430
82surfactant homeostasis (GO:0043129)2.28983172
83negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.28434755
84substrate-dependent cell migration (GO:0006929)2.28132024
85regulation of glomerulus development (GO:0090192)2.27636804
86positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.23877859
87protein targeting to plasma membrane (GO:0072661)2.23649765
88heart valve morphogenesis (GO:0003179)2.23088988
89cortical cytoskeleton organization (GO:0030865)2.22846193
90endocytic recycling (GO:0032456)2.22312589
91dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.21845168
92embryonic retina morphogenesis in camera-type eye (GO:0060059)2.21382241
93glomerulus development (GO:0032835)2.21192226
94mating behavior (GO:0007617)2.20300134
95cellular response to epinephrine stimulus (GO:0071872)2.19538784
96regulation of muscle hypertrophy (GO:0014743)2.19492255
97negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.19486744
98basement membrane organization (GO:0071711)2.19031492
99negative regulation of chondrocyte differentiation (GO:0032331)2.18617446
100establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.18396771
101cellular response to prostaglandin stimulus (GO:0071379)2.17877673
102regulation of glucose import in response to insulin stimulus (GO:2001273)2.17697399
103myoblast fusion (GO:0007520)2.16897388
104Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.16548833
105regulation of striated muscle cell apoptotic process (GO:0010662)2.15983906
106glomerular epithelial cell development (GO:0072310)2.15492100
107positive regulation of adherens junction organization (GO:1903393)2.15416540
108regulation of cAMP-dependent protein kinase activity (GO:2000479)2.14942533
109mesenchyme morphogenesis (GO:0072132)2.14444287
110cardiac chamber formation (GO:0003207)2.14242432
111negative regulation of complement activation (GO:0045916)2.13981152
112negative regulation of protein localization to plasma membrane (GO:1903077)2.13584818
113mammary gland development (GO:0030879)2.12901763
114neural tube formation (GO:0001841)2.12752595
115protein localization to microtubule (GO:0035372)2.12405750
116positive regulation of cellular response to insulin stimulus (GO:1900078)2.12402711
117regulation of p38MAPK cascade (GO:1900744)2.11703196
118negative regulation of muscle hypertrophy (GO:0014741)2.10810374
119sympathetic nervous system development (GO:0048485)2.10334925
120positive regulation of glycogen metabolic process (GO:0070875)2.10283726
121protein hydroxylation (GO:0018126)2.10117062
122regulation of nucleobase-containing compound transport (GO:0032239)2.10031027
123regulation of establishment of planar polarity (GO:0090175)2.10024481
124establishment of nucleus localization (GO:0040023)2.09981655
125cytoplasmic mRNA processing body assembly (GO:0033962)2.09682127
126protein heterotrimerization (GO:0070208)2.09412001
127embryonic camera-type eye morphogenesis (GO:0048596)2.08720723
128platelet-derived growth factor receptor signaling pathway (GO:0048008)2.08354631
129vascular endothelial growth factor signaling pathway (GO:0038084)2.08192407
130cerebellar granule cell differentiation (GO:0021707)2.08028974
131barbed-end actin filament capping (GO:0051016)2.07724836
132establishment of tissue polarity (GO:0007164)2.07672129
133establishment of planar polarity (GO:0001736)2.07672129
134ear development (GO:0043583)2.07606680
135axon extension (GO:0048675)2.07484601
136histone H3-K9 demethylation (GO:0033169)2.07194957
137metanephros development (GO:0001656)2.06617076
138positive regulation of male gonad development (GO:2000020)2.06375044
139syncytium formation by plasma membrane fusion (GO:0000768)2.06075922
140positive regulation of blood vessel endothelial cell migration (GO:0043536)2.05658667
141mesenchymal cell development (GO:0014031)2.05457393
142regulation of axon extension involved in axon guidance (GO:0048841)2.05263548
143asymmetric protein localization (GO:0008105)2.04263945
144negative regulation of sodium ion transport (GO:0010766)2.04144382
145pericardium development (GO:0060039)2.03574327
146vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.03384261
147cell communication by electrical coupling (GO:0010644)2.03251546
148Golgi transport vesicle coating (GO:0048200)2.02784857
149COPI coating of Golgi vesicle (GO:0048205)2.02784857
150regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.02143759
151regulation of smooth muscle cell differentiation (GO:0051150)2.02095950
152regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.02022041
153myelination in peripheral nervous system (GO:0022011)2.01824661
154peripheral nervous system axon ensheathment (GO:0032292)2.01824661
155clathrin coat assembly (GO:0048268)2.01745610
156positive regulation of cell junction assembly (GO:1901890)2.01172652
157positive regulation of focal adhesion assembly (GO:0051894)2.01172652
158regulation of receptor recycling (GO:0001919)2.00865704
159regulation of cardiac muscle cell differentiation (GO:2000725)2.00340720
160neuron projection extension (GO:1990138)2.00213587
161negative regulation of mast cell activation (GO:0033004)1.99887883
162iron ion import (GO:0097286)1.98795964
163regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)1.98736824
164positive regulation of stem cell differentiation (GO:2000738)1.98263488
165cardiac myofibril assembly (GO:0055003)1.97889538
166sarcomere organization (GO:0045214)1.96859513
167chondrocyte development (GO:0002063)1.94984051
168cardiac muscle hypertrophy (GO:0003300)1.94532355
169positive regulation of myoblast differentiation (GO:0045663)1.94358854
170regulation of polysaccharide biosynthetic process (GO:0032885)1.94261385
171embryonic skeletal joint morphogenesis (GO:0060272)1.94174565
172actin-mediated cell contraction (GO:0070252)1.94080809
173cellular glucuronidation (GO:0052695)1.93739129
174cranial suture morphogenesis (GO:0060363)1.93215233
175actomyosin structure organization (GO:0031032)1.93185888
176positive regulation of cartilage development (GO:0061036)1.92736337
177negative regulation of muscle cell apoptotic process (GO:0010656)1.91771506
178hippo signaling (GO:0035329)1.90433524
179negative regulation of keratinocyte proliferation (GO:0010839)1.90065264
180cardiac ventricle formation (GO:0003211)1.89789191
181response to follicle-stimulating hormone (GO:0032354)1.88759627
182negative regulation of protein activation cascade (GO:2000258)1.88422357
183cartilage development involved in endochondral bone morphogenesis (GO:0060351)1.88191841
184fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)1.87634082
185uronic acid metabolic process (GO:0006063)1.87602124
186glucuronate metabolic process (GO:0019585)1.87602124

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.10153495
2SMAD_19615063_ChIP-ChIP_OVARY_Human2.76110559
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.73236444
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.30024520
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24505536
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.12212667
7ESR1_20079471_ChIP-ChIP_T-47D_Human2.11578743
8* FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.10150502
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02789487
10* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.00167821
11STAT6_21828071_ChIP-Seq_BEAS2B_Human1.93178530
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.90898875
13ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.88911663
14WT1_19549856_ChIP-ChIP_CCG9911_Human1.87688070
15* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77067804
16AHR_22903824_ChIP-Seq_MCF-7_Human1.77022718
17EP300_21415370_ChIP-Seq_HL-1_Mouse1.76508966
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.76377294
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.76089865
20CJUN_26792858_Chip-Seq_BT549_Human1.69613179
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69428026
22* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.67399421
23NRF2_20460467_ChIP-Seq_MEFs_Mouse1.64813628
24NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.64813628
25* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.60133284
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.57390462
27* KDM2B_26808549_Chip-Seq_K562_Human1.53115470
28* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.52688098
29RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.50871895
30ARNT_22903824_ChIP-Seq_MCF-7_Human1.50745309
31* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49202569
32* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49186580
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.49145474
34GBX2_23144817_ChIP-Seq_PC3_Human1.47534284
35NFIB_24661679_ChIP-Seq_LUNG_Mouse1.46470796
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46175482
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.44988722
38SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.43938671
39SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.43938671
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.41899837
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41508445
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39928075
43* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39576781
44P300_27058665_Chip-Seq_ZR-75-30cells_Human1.39491491
45LXR_22158963_ChIP-Seq_LIVER_Mouse1.37529296
46TP53_16413492_ChIP-PET_HCT116_Human1.36892171
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34029875
48CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.33904989
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32354995
50STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.31715961
51* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.31442752
52* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.31290898
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.30878153
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.30193543
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.30193543
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28284753
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27582733
58TP53_18474530_ChIP-ChIP_U2OS_Human1.27136302
59HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27057015
60SMAD4_21799915_ChIP-Seq_A2780_Human1.27005364
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26192368
62KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26072664
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.24619871
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23162155
65* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22795685
66ISL1_27105846_Chip-Seq_CPCs_Mouse1.22404387
67EED_16625203_ChIP-ChIP_MESCs_Mouse1.22113618
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22073928
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21225688
70* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20990246
71SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19655734
72EGR1_19374776_ChIP-ChIP_THP-1_Human1.19460732
73* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19273731
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18845457
75* CLOCK_20551151_ChIP-Seq_293T_Human1.18776215
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16919435
77ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16764502
78* GATA1_19941826_ChIP-Seq_K562_Human1.14549391
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13860755
80RNF2_27304074_Chip-Seq_ESCs_Mouse1.13331329
81SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13039771
82YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12563905
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11750668
84* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11283521
85ESR2_21235772_ChIP-Seq_MCF-7_Human1.10799002
86PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10494166
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10273154
88RXR_22108803_ChIP-Seq_LS180_Human1.08576295
89RXR_22158963_ChIP-Seq_LIVER_Mouse1.08351448
90ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07237655
91* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07206795
92SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07095776
93POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06736081
94SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06723497
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06548461
96STAT3_23295773_ChIP-Seq_U87_Human1.06072206
97ELK3_25401928_ChIP-Seq_HUVEC_Human1.06031853
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05522405
99TCF7_22412390_ChIP-Seq_EML_Mouse1.04573207
100P300_19829295_ChIP-Seq_ESCs_Human1.01696424
101VDR_24787735_ChIP-Seq_THP-1_Human1.01010826
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99900389
103* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99261476
104NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98874679
105TP63_23658742_ChIP-Seq_EP156T_Human0.98825195
106SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98583157
107TP63_17297297_ChIP-ChIP_HaCaT_Human0.98579822
108* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97714147
109* SOX2_20726797_ChIP-Seq_SW620_Human0.96031346
110KDM2B_26808549_Chip-Seq_JURKAT_Human0.94830537
111FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94740796
112Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94627962
113ZNF263_19887448_ChIP-Seq_K562_Human0.94144308
114UBF1/2_26484160_Chip-Seq_HMECs_Human0.93951003
115ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93798059
116RACK7_27058665_Chip-Seq_MCF-7_Human0.92366073
117FOXA2_19822575_ChIP-Seq_HepG2_Human0.92160583
118CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.92000647
119BRD4_25478319_ChIP-Seq_HGPS_Human0.91970672
120ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91940822
121EZH2_27304074_Chip-Seq_ESCs_Mouse0.91369825
122* GATA2_19941826_ChIP-Seq_K562_Human0.90846624
123TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90697618
124CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90561162
125KDM2B_26808549_Chip-Seq_DND41_Human0.90520958
126PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.90377500
127SOX2_21211035_ChIP-Seq_LN229_Gbm0.90312016
128JARID2_20075857_ChIP-Seq_MESCs_Mouse0.90165445
129RUNX_20019798_ChIP-Seq_JUKART_Human0.90161968
130ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89533940
131ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89290011
132MTF2_20144788_ChIP-Seq_MESCs_Mouse0.89146741
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.88345261
134AR_19668381_ChIP-Seq_PC3_Human0.87645331
135SMAD4_21741376_ChIP-Seq_HESCs_Human0.86927287
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86920140
137ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86592907
138TBX20_22328084_ChIP-Seq_HEART_Mouse0.86248270
139TBX20_22080862_ChIP-Seq_HEART_Mouse0.86248270
140AR_21572438_ChIP-Seq_LNCaP_Human0.85311411
141* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.85264870
142PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85222610
143BCAT_22108803_ChIP-Seq_LS180_Human0.85203603
144SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.84572209
145SMAD3_21741376_ChIP-Seq_EPCs_Human0.84217087
146RING1B_27294783_Chip-Seq_NPCs_Mouse0.82680069

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.87438898
2MP0005503_abnormal_tendon_morphology3.66148323
3MP0005409_darkened_coat_color2.83374528
4MP0003787_abnormal_imprinting2.70643305
5MP0003091_abnormal_cell_migration2.68586278
6MP0005275_abnormal_skin_tensile2.59029521
7MP0008789_abnormal_olfactory_epithelium2.47605288
8MP0003279_aneurysm2.34789599
9MP0003705_abnormal_hypodermis_morpholog2.33356965
10MP0003385_abnormal_body_wall2.26752870
11MP0003122_maternal_imprinting2.14899348
12MP0001177_atelectasis2.10196201
13MP0004510_myositis2.06715843
14MP0010368_abnormal_lymphatic_system2.04420367
15MP0010234_abnormal_vibrissa_follicle2.04087052
16MP0002139_abnormal_hepatobiliary_system2.03784956
17MP0002877_abnormal_melanocyte_morpholog2.00086347
18MP0009250_abnormal_appendicular_skeleto1.99368930
19MP0003942_abnormal_urinary_system1.97151607
20MP0005394_taste/olfaction_phenotype1.96812980
21MP0005499_abnormal_olfactory_system1.96812980
22MP0004134_abnormal_chest_morphology1.94165039
23MP0004272_abnormal_basement_membrane1.93921465
24MP0003453_abnormal_keratinocyte_physiol1.90161615
25MP0005248_abnormal_Harderian_gland1.77407613
26MP0005023_abnormal_wound_healing1.77044766
27MP0001879_abnormal_lymphatic_vessel1.75084926
28MP0005076_abnormal_cell_differentiation1.73015335
29MP0008260_abnormal_autophagy1.72838422
30MP0009053_abnormal_anal_canal1.72569626
31MP0003941_abnormal_skin_development1.71303244
32MP0005367_renal/urinary_system_phenotyp1.67915691
33MP0000516_abnormal_urinary_system1.67915691
34MP0003300_gastrointestinal_ulcer1.67474107
35MP0000534_abnormal_ureter_morphology1.67015365
36MP0009780_abnormal_chondrocyte_physiolo1.66645113
37MP0010352_gastrointestinal_tract_polyps1.63509175
38MP0000751_myopathy1.63161396
39MP0003329_amyloid_beta_deposits1.62246412
40MP0005408_hypopigmentation1.59735041
41MP0003121_genomic_imprinting1.57971139
42MP0002837_dystrophic_cardiac_calcinosis1.57424813
43MP0001849_ear_inflammation1.56157659
44MP0005623_abnormal_meninges_morphology1.53188341
45MP0005171_absent_coat_pigmentation1.52443032
46MP0001984_abnormal_olfaction1.48680249
47MP0000762_abnormal_tongue_morphology1.48006414
48MP0002972_abnormal_cardiac_muscle1.45457591
49MP0000733_abnormal_muscle_development1.44181887
50MP0004859_abnormal_synaptic_plasticity1.44175674
51MP0009384_cardiac_valve_regurgitation1.42989768
52MP0005365_abnormal_bile_salt1.42632708
53MP0005508_abnormal_skeleton_morphology1.38903218
54MP0003950_abnormal_plasma_membrane1.38048065
55MP0001958_emphysema1.36876385
56MP0009697_abnormal_copulation1.35596477
57MP0000579_abnormal_nail_morphology1.35403915
58MP0002168_other_aberrant_phenotype1.33863673
59MP0005085_abnormal_gallbladder_physiolo1.33338658
60MP0003828_pulmonary_edema1.31351792
61MP0003045_fibrosis1.29869260
62MP0003755_abnormal_palate_morphology1.26781429
63MP0002233_abnormal_nose_morphology1.26144204
64MP0002108_abnormal_muscle_morphology1.23783486
65MP0000767_abnormal_smooth_muscle1.22773365
66MP0004185_abnormal_adipocyte_glucose1.22165496
67MP0003115_abnormal_respiratory_system1.20988684
68MP0004087_abnormal_muscle_fiber1.19595244
69MP0002295_abnormal_pulmonary_circulatio1.18572003
70MP0002115_abnormal_skeleton_extremities1.17691339
71MP0002876_abnormal_thyroid_physiology1.17284141
72MP0003690_abnormal_glial_cell1.16809429
73MP0003943_abnormal_hepatobiliary_system1.15317213
74MP0002133_abnormal_respiratory_system1.14867889
75MP0005388_respiratory_system_phenotype1.14867889
76MP0010630_abnormal_cardiac_muscle1.14807152
77MP0002132_abnormal_respiratory_system1.13836589
78MP0005666_abnormal_adipose_tissue1.12525585
79MP0004130_abnormal_muscle_cell1.12314351
80MP0006138_congestive_heart_failure1.10413124
81MP0004036_abnormal_muscle_relaxation1.10024868
82MP0004883_abnormal_blood_vessel1.09923451
83MP0001542_abnormal_bone_strength1.08687302
84MP0005375_adipose_tissue_phenotype1.06744305
85MP0003935_abnormal_craniofacial_develop1.06584984
86MP0002060_abnormal_skin_morphology1.05349143
87MP0004858_abnormal_nervous_system1.04735567
88MP0003252_abnormal_bile_duct1.04429626
89MP0005646_abnormal_pituitary_gland1.03998979
90MP0004084_abnormal_cardiac_muscle1.03348639
91MP0001544_abnormal_cardiovascular_syste1.02722467
92MP0005385_cardiovascular_system_phenoty1.02722467
93MP0002009_preneoplasia1.02594331
94MP0000003_abnormal_adipose_tissue1.02570355
95MP0005620_abnormal_muscle_contractility1.02093873
96MP0003634_abnormal_glial_cell1.00790529
97MP0002896_abnormal_bone_mineralization1.00026437
98MP0002909_abnormal_adrenal_gland0.99917104
99MP0010678_abnormal_skin_adnexa0.99515605
100MP0000163_abnormal_cartilage_morphology0.98684270
101MP0002933_joint_inflammation0.97982312
102MP0000749_muscle_degeneration0.96652543
103MP0003656_abnormal_erythrocyte_physiolo0.95459973
104MP0000747_muscle_weakness0.94653276
105MP0004782_abnormal_surfactant_physiolog0.94497858
106MP0008004_abnormal_stomach_pH0.93730745
107MP0008775_abnormal_heart_ventricle0.92829652
108MP0005595_abnormal_vascular_smooth0.92507094
109MP0010329_abnormal_lipoprotein_level0.90913899
110MP0000569_abnormal_digit_pigmentation0.90155440
111MP0000759_abnormal_skeletal_muscle0.89700034
112MP0005257_abnormal_intraocular_pressure0.89589442
113MP0003303_peritoneal_inflammation0.88516379
114MP0005197_abnormal_uvea_morphology0.87838413
115MP0000778_abnormal_nervous_system0.87715775
116MP0004233_abnormal_muscle_weight0.87336613
117MP0003191_abnormal_cellular_cholesterol0.85915726
118MP0005670_abnormal_white_adipose0.84088203
119MP0002796_impaired_skin_barrier0.84007791
120MP0005621_abnormal_cell_physiology0.83065709
121MP0002089_abnormal_postnatal_growth/wei0.83020929
122MP0002925_abnormal_cardiovascular_devel0.82834088
123MP0000372_irregular_coat_pigmentation0.81194157
124MP0010030_abnormal_orbit_morphology0.81094716
125MP0001299_abnormal_eye_distance/0.80975592
126MP0003566_abnormal_cell_adhesion0.80725501
127MP0001614_abnormal_blood_vessel0.80198424
128MP0002998_abnormal_bone_remodeling0.78887305
129MP0005360_urolithiasis0.78169274
130MP0004085_abnormal_heartbeat0.77904502
131MP0000537_abnormal_urethra_morphology0.76680603
132MP0002128_abnormal_blood_circulation0.76329566
133MP0001175_abnormal_lung_morphology0.76313301
134MP0000858_altered_metastatic_potential0.75954548
135MP0002109_abnormal_limb_morphology0.75439140
136MP0005451_abnormal_body_composition0.75024225
137MP0002971_abnormal_brown_adipose0.73389461
138MP0001915_intracranial_hemorrhage0.73173614
139MP0000750_abnormal_muscle_regeneration0.72692546
140MP0002332_abnormal_exercise_endurance0.71342042
141MP0000432_abnormal_head_morphology0.70841698
142MP0004264_abnormal_extraembryonic_tissu0.70737206
143MP0001286_abnormal_eye_development0.70694889
144MP0005164_abnormal_response_to0.70556990
145MP0002113_abnormal_skeleton_development0.70255192
146MP0004484_altered_response_of0.69842899
147MP0000428_abnormal_craniofacial_morphol0.68591010
148MP0005390_skeleton_phenotype0.68339030
149MP0000639_abnormal_adrenal_gland0.67612784

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)3.77234654
2Hepatoblastoma (HP:0002884)3.63839009
3Abnormality of incisor morphology (HP:0011063)3.55212410
4Asymmetry of the thorax (HP:0001555)3.44863048
5Atrophic scars (HP:0001075)3.31637327
6Neoplasm of the adrenal cortex (HP:0100641)3.26119981
7Neonatal hypoglycemia (HP:0001998)3.05444962
8Neurofibrillary tangles (HP:0002185)2.91605506
9Thyroid carcinoma (HP:0002890)2.90565483
10Cerebral inclusion bodies (HP:0100314)2.86805739
11Vascular tortuosity (HP:0004948)2.83102460
12Aortic aneurysm (HP:0004942)2.81275088
13Enlarged kidneys (HP:0000105)2.74178141
14Subacute progressive viral hepatitis (HP:0006572)2.72074853
15Bladder diverticulum (HP:0000015)2.66231356
16Neoplasm of the adrenal gland (HP:0100631)2.62097147
17Abnormality of the ischium (HP:0003174)2.59184484
18Hypothermia (HP:0002045)2.55589000
19Obstructive sleep apnea (HP:0002870)2.55353355
20Absent eyebrow (HP:0002223)2.55316834
21Mitral valve prolapse (HP:0001634)2.51784277
22Cerebral aneurysm (HP:0004944)2.49683665
23Meningioma (HP:0002858)2.49233221
24Neonatal short-limb short stature (HP:0008921)2.48431795
25Submucous cleft hard palate (HP:0000176)2.47573506
26Overgrowth (HP:0001548)2.44139340
27Bilateral sensorineural hearing impairment (HP:0008619)2.43596626
28Abnormality of the intervertebral disk (HP:0005108)2.42522063
29Curly hair (HP:0002212)2.40092011
30Abnormality of the nasal septum (HP:0000419)2.39317462
31Deep philtrum (HP:0002002)2.38540434
32Alveolar cell carcinoma (HP:0006519)2.38438662
33Aortic dissection (HP:0002647)2.37645728
34Increased variability in muscle fiber diameter (HP:0003557)2.37531668
35Fragile skin (HP:0001030)2.37326518
36Syringomyelia (HP:0003396)2.36994980
37Spinal cord lesions (HP:0100561)2.36994980
38Mitral stenosis (HP:0001718)2.36528581
39Vitreoretinal degeneration (HP:0000655)2.36084408
40Hyporeflexia of lower limbs (HP:0002600)2.31012983
41Osteolytic defects of the hand bones (HP:0009699)2.29044724
42Osteolytic defects of the phalanges of the hand (HP:0009771)2.29044724
43Soft skin (HP:0000977)2.27020653
44Arterial tortuosity (HP:0005116)2.26164303
45Hepatocellular carcinoma (HP:0001402)2.18260359
46Bell-shaped thorax (HP:0001591)2.18084240
47Hyperextensible skin (HP:0000974)2.16312529
48Mitral regurgitation (HP:0001653)2.14857826
49Peritonitis (HP:0002586)2.14690902
50Broad metatarsal (HP:0001783)2.12951898
51Muscle fiber splitting (HP:0003555)2.11819185
52Genu recurvatum (HP:0002816)2.10552401
53Absent frontal sinuses (HP:0002688)2.10375375
54Dilatation of the ascending aorta (HP:0005111)2.09347199
55Aneurysm (HP:0002617)2.08603497
56Neoplasm of the tracheobronchial system (HP:0100552)2.08511610
57Abnormality of skeletal muscle fiber size (HP:0012084)2.04793416
58Right ventricular cardiomyopathy (HP:0011663)2.04271879
59Mesomelia (HP:0003027)2.03086858
60Chorioretinal atrophy (HP:0000533)1.99370645
61Follicular hyperkeratosis (HP:0007502)1.98126562
62Ulnar bowing (HP:0003031)1.95189018
63Hyperacusis (HP:0010780)1.94429015
64Absent eyelashes (HP:0000561)1.93859317
65Distal lower limb muscle weakness (HP:0009053)1.93565875
66Ankle contracture (HP:0006466)1.92491233
67Spinal rigidity (HP:0003306)1.92377171
68Midline defect of the nose (HP:0004122)1.90506986
69Hyperglycemia (HP:0003074)1.90376387
70Wormian bones (HP:0002645)1.89989731
71Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.89357725
72Cystic hygroma (HP:0000476)1.88719952
73Morphological abnormality of the middle ear (HP:0008609)1.88623770
74Abnormality of the aortic arch (HP:0012303)1.88490943
75Abnormality of dentin (HP:0010299)1.88283851
76Abnormal pancreas size (HP:0012094)1.87701762
77Increased connective tissue (HP:0009025)1.86361692
78Difficulty running (HP:0009046)1.85015977
79Diastasis recti (HP:0001540)1.84168743
80Protrusio acetabuli (HP:0003179)1.83584263
81Pheochromocytoma (HP:0002666)1.83548673
82Striae distensae (HP:0001065)1.83142586
83Ankyloglossia (HP:0010296)1.82059952
84Vertebral arch anomaly (HP:0008438)1.80652918
85Epiphyseal dysplasia (HP:0002656)1.79931537
86Hypoplasia of the iris (HP:0007676)1.79756337
87Nuclear cataract (HP:0100018)1.79266431
88Turricephaly (HP:0000262)1.78815204
89Insulin-resistant diabetes mellitus (HP:0000831)1.78594190
90Shallow orbits (HP:0000586)1.77393051
91Distal upper limb amyotrophy (HP:0007149)1.77307952
92Upper limb amyotrophy (HP:0009129)1.77307952
93Enlarged epiphyses (HP:0010580)1.77208898
94Insomnia (HP:0100785)1.77164016
95Arnold-Chiari malformation (HP:0002308)1.76751713
96Slow-growing hair (HP:0002217)1.75204806
97Abnormality of hair growth rate (HP:0011363)1.75204806
98Myocardial infarction (HP:0001658)1.75032216
99Osteomalacia (HP:0002749)1.74979176
100Joint laxity (HP:0001388)1.74133042
101Accelerated skeletal maturation (HP:0005616)1.73734930
102Abnormal hair whorl (HP:0010721)1.73242515
103Hammertoe (HP:0001765)1.72579391
104Wide anterior fontanel (HP:0000260)1.72399307
105Short nail (HP:0001799)1.71780008
106Type 1 muscle fiber predominance (HP:0003803)1.71029137
107Foot dorsiflexor weakness (HP:0009027)1.70902290
108Germ cell neoplasia (HP:0100728)1.70217133
109Neoplasm of the liver (HP:0002896)1.69909108
110Aplasia involving bones of the upper limbs (HP:0009823)1.69786185
111Aplasia of the phalanges of the hand (HP:0009802)1.69786185
112Aplasia involving bones of the extremities (HP:0009825)1.69786185
113Hypoplastic ischia (HP:0003175)1.69785489
114Tibial bowing (HP:0002982)1.69682134
115Hypoplastic left heart (HP:0004383)1.69346329
116Abnormality of the anterior chamber (HP:0000593)1.69193331
117Pulmonary artery stenosis (HP:0004415)1.68701847
118Blue sclerae (HP:0000592)1.68582214
119Myelomeningocele (HP:0002475)1.67664819
120Premature rupture of membranes (HP:0001788)1.66673282
121Scapular winging (HP:0003691)1.66653435
122Pigmentary retinal degeneration (HP:0001146)1.66323242
123Deep venous thrombosis (HP:0002625)1.66165618
124Febrile seizures (HP:0002373)1.66022532
125Vertebral compression fractures (HP:0002953)1.65591278
126Distal lower limb amyotrophy (HP:0008944)1.64827463
127Exercise-induced muscle cramps (HP:0003710)1.64602049
128Alopecia of scalp (HP:0002293)1.63500792
129Bradycardia (HP:0001662)1.62934251
130Abnormality of the distal phalanx of the thumb (HP:0009617)1.61796899
131Cubitus valgus (HP:0002967)1.60819657
132Cupped ribs (HP:0000887)1.60784215
133Tarsal synostosis (HP:0008368)1.60204503
134Stridor (HP:0010307)1.60132376
135Wrist flexion contracture (HP:0001239)1.59310079
136Pulmonic stenosis (HP:0001642)1.59290628
137Decreased motor nerve conduction velocity (HP:0003431)1.58433410
138Mildly elevated creatine phosphokinase (HP:0008180)1.58152869
139Hand muscle atrophy (HP:0009130)1.58121690
140Camptodactyly of toe (HP:0001836)1.57296350
141Abnormality of the foot musculature (HP:0001436)1.57246828
142Preauricular pit (HP:0004467)1.57098232
143Periauricular skin pits (HP:0100277)1.57098232
144Hypophosphatemic rickets (HP:0004912)1.56647862
145Abnormality of the fingertips (HP:0001211)1.56430623
146Hypercortisolism (HP:0001578)1.56076620
147Coronal craniosynostosis (HP:0004440)1.55870306
148Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.55730582
149Narrow nasal bridge (HP:0000446)1.55146212
150Spondylolisthesis (HP:0003302)1.54574262
151Bowel diverticulosis (HP:0005222)1.54424626
152Cervical subluxation (HP:0003308)1.54344955
153Bundle branch block (HP:0011710)1.54157553
154Flat acetabular roof (HP:0003180)1.53999196
155Difficulty climbing stairs (HP:0003551)1.53837463
156Adrenal hypoplasia (HP:0000835)1.53689434
157Asymmetric septal hypertrophy (HP:0001670)1.53510850
158Blue irides (HP:0000635)1.53148198
159Tubulointerstitial fibrosis (HP:0005576)1.53037994
160Short hallux (HP:0010109)1.52095149
161Broad face (HP:0000283)1.50860536
162Subaortic stenosis (HP:0001682)1.50677143
163Abnormality of the left ventricular outflow tract (HP:0011103)1.50677143
164Advanced eruption of teeth (HP:0006288)1.50559289
165Mild short stature (HP:0003502)1.50364755
166Ventricular tachycardia (HP:0004756)1.50249425
167Centrally nucleated skeletal muscle fibers (HP:0003687)1.49209880
168Back pain (HP:0003418)1.48974167
169Round ear (HP:0100830)1.48919673
170Pterygium (HP:0001059)1.48674076
171Lower limb amyotrophy (HP:0007210)1.48512589
172Hyperkalemia (HP:0002153)1.47282081
173Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.46430941
174Tetraparesis (HP:0002273)1.46343350
175Coxa vara (HP:0002812)1.46323949

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT33.76372156
2STK38L3.57447541
3PRPF4B3.21372161
4SGK23.21045912
5ERBB32.96818273
6STK242.93486394
7NTRK12.87361443
8SGK32.62740035
9SGK2232.53889346
10SGK4942.53889346
11BMPR22.42270840
12ZAK2.29366608
13FRK2.23584064
14EPHA21.99688784
15MAP3K91.89322486
16SIK31.87789686
17TTN1.79993172
18CDK121.76577058
19MET1.73291854
20PRKCH1.72882313
21NEK91.65426068
22MAP3K141.63442260
23PLK21.62936277
24ICK1.56090506
25PKN21.52618340
26BCR1.52057217
27TNIK1.48238880
28MAP3K131.47684627
29PRKD31.47262459
30FGFR31.47208118
31MOS1.46570422
32EPHA31.45422207
33OBSCN1.40103952
34SIK11.39328329
35MAP3K101.35392986
36YES11.33418876
37PIK3CA1.31241334
38LATS11.28243140
39MARK21.25822040
40KSR11.24479831
41KSR21.24134367
42STK31.23346033
43MAP3K21.22983905
44TYRO31.22639430
45PDGFRA1.20922603
46EPHB21.19963327
47FGFR21.19812089
48STK381.18609896
49EEF2K1.16925235
50DDR21.15179057
51MYLK1.13327396
52CAMK1G1.11484842
53LMTK21.10133134
54MST1R1.10055916
55ERN11.04162549
56BMX1.01386556
57MTOR1.00745095
58RET0.97606718
59ERBB40.94849341
60TRIB30.94750579
61TRPM70.94522863
62RPS6KA20.92531867
63ROCK10.92320011
64ARAF0.90026417
65RIPK10.89922533
66CHUK0.89246515
67FGFR40.88693763
68CDC42BPA0.88236914
69PAK30.87149111
70TAOK10.86895173
71WNK10.86755875
72MAP3K60.83947650
73TXK0.83807424
74RPS6KB10.83316734
75JAK10.83270112
76NEK60.82836791
77NUAK10.82831567
78PIK3CG0.80329870
79CASK0.79223629
80MARK10.77249648
81FGR0.76203964
82LIMK10.74615347
83MAP2K10.73703242
84FER0.73685122
85CAMK1D0.73465547
86LRRK20.71471993
87DYRK1B0.70970525
88PDGFRB0.70143825
89PRKCE0.68784260
90BMPR1B0.68727507
91MAP2K30.63375825
92MAP3K10.63159156
93HIPK20.62436996
94PLK40.62114684
95MAPK130.61292816
96PRKD20.61025210
97MAPK70.60215898
98PTK2B0.59189278
99NLK0.59173613
100SMG10.59049033
101PAK20.58834437
102CSK0.55885800
103MAP3K70.55757647
104SGK10.55460856
105MAP2K70.54643914
106EPHB10.52948870
107MINK10.50255013
108ITK0.50113046
109PAK40.49298055
110ERBB20.49092340
111NTRK30.48889649
112PRKCQ0.48748038
113WNK40.48525655
114LATS20.48505202
115PTK20.48176060
116MAP3K30.48115196
117BRD40.47848075
118RPS6KL10.47461820
119RPS6KC10.47461820
120MAPK100.46996758
121ROCK20.46366124
122TAOK20.46304721
123RPS6KA60.46196687
124DYRK20.45242131
125CDK60.44922589
126GSK3A0.44606823
127DMPK0.44529393
128IKBKE0.43313643
129PLK30.41613039
130PDPK10.41361066
131FGFR10.41340908
132MST40.40884923
133NTRK20.40353242
134PRKAA10.39549768
135STK100.38943380
136TGFBR20.38683396
137MAPK80.38194052
138IRAK30.37848220
139SIK20.37839169
140CDK90.37295081
141PRKCZ0.37070391
142DAPK20.35241703
143MAP3K40.33923484
144MELK0.33160922
145STK390.32341525
146MARK30.31752381
147IGF1R0.31411544
148CAMK40.30469862
149PTK60.30031570
150MAPK30.29843834
151PAK60.28904172
152INSRR0.28768592

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.99133795
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.80646238
3Endometrial cancer_Homo sapiens_hsa052131.73547628
4Adherens junction_Homo sapiens_hsa045201.57421759
5Fatty acid metabolism_Homo sapiens_hsa012121.50872202
6Fatty acid degradation_Homo sapiens_hsa000711.36547654
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31280072
8Propanoate metabolism_Homo sapiens_hsa006401.30795617
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29370694
10Hippo signaling pathway_Homo sapiens_hsa043901.29069379
11Focal adhesion_Homo sapiens_hsa045101.27521521
12Notch signaling pathway_Homo sapiens_hsa043301.25719128
13PPAR signaling pathway_Homo sapiens_hsa033201.25333771
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.23276461
15Prostate cancer_Homo sapiens_hsa052151.23270781
16Dorso-ventral axis formation_Homo sapiens_hsa043201.22499961
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.22209167
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.20614859
19Olfactory transduction_Homo sapiens_hsa047401.20258478
20ECM-receptor interaction_Homo sapiens_hsa045121.19497948
21Small cell lung cancer_Homo sapiens_hsa052221.18709625
22Dilated cardiomyopathy_Homo sapiens_hsa054141.16876005
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15301014
24Prion diseases_Homo sapiens_hsa050201.12943032
25Long-term potentiation_Homo sapiens_hsa047201.11871127
26FoxO signaling pathway_Homo sapiens_hsa040681.11723603
27Phospholipase D signaling pathway_Homo sapiens_hsa040721.09038354
28Sulfur metabolism_Homo sapiens_hsa009201.08928799
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.08639939
30Insulin resistance_Homo sapiens_hsa049311.07908288
31VEGF signaling pathway_Homo sapiens_hsa043701.07748940
32Tight junction_Homo sapiens_hsa045301.06827515
33Steroid biosynthesis_Homo sapiens_hsa001001.06782742
34Bladder cancer_Homo sapiens_hsa052191.03675980
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02585562
36Estrogen signaling pathway_Homo sapiens_hsa049151.02415888
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00627835
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00120665
39Thyroid cancer_Homo sapiens_hsa052160.98755892
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98140396
41Pancreatic cancer_Homo sapiens_hsa052120.97178384
42TGF-beta signaling pathway_Homo sapiens_hsa043500.96717291
43Gap junction_Homo sapiens_hsa045400.96157049
44Choline metabolism in cancer_Homo sapiens_hsa052310.94981528
45GnRH signaling pathway_Homo sapiens_hsa049120.94091340
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.94047769
47Rap1 signaling pathway_Homo sapiens_hsa040150.92975734
48Proteoglycans in cancer_Homo sapiens_hsa052050.89494158
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86764127
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86164870
51Prolactin signaling pathway_Homo sapiens_hsa049170.85894795
52Complement and coagulation cascades_Homo sapiens_hsa046100.85837489
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85725970
54Axon guidance_Homo sapiens_hsa043600.85070064
55Chronic myeloid leukemia_Homo sapiens_hsa052200.82562803
56Fatty acid biosynthesis_Homo sapiens_hsa000610.81997947
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81210201
58ErbB signaling pathway_Homo sapiens_hsa040120.80659408
59Starch and sucrose metabolism_Homo sapiens_hsa005000.79044041
60Peroxisome_Homo sapiens_hsa041460.78550710
61Amoebiasis_Homo sapiens_hsa051460.78425141
62Melanoma_Homo sapiens_hsa052180.78254741
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.76825416
64Tryptophan metabolism_Homo sapiens_hsa003800.76748151
65Basal cell carcinoma_Homo sapiens_hsa052170.76193237
66Platelet activation_Homo sapiens_hsa046110.75081234
67HIF-1 signaling pathway_Homo sapiens_hsa040660.74718820
68Glioma_Homo sapiens_hsa052140.74684883
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73806054
70Endocytosis_Homo sapiens_hsa041440.73660258
71Inositol phosphate metabolism_Homo sapiens_hsa005620.72939180
72PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72697512
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.72589676
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71634263
75Colorectal cancer_Homo sapiens_hsa052100.71505534
76Lysine degradation_Homo sapiens_hsa003100.70393415
77beta-Alanine metabolism_Homo sapiens_hsa004100.70154477
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69296207
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69212763
80Hepatitis C_Homo sapiens_hsa051600.69081748
81Ras signaling pathway_Homo sapiens_hsa040140.69013183
82Renal cell carcinoma_Homo sapiens_hsa052110.66875063
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66345843
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66027834
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65881553
86Viral myocarditis_Homo sapiens_hsa054160.65637045
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65404403
88Staphylococcus aureus infection_Homo sapiens_hsa051500.65029473
89Type II diabetes mellitus_Homo sapiens_hsa049300.64528341
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64233333
91Insulin signaling pathway_Homo sapiens_hsa049100.64226801
92Hedgehog signaling pathway_Homo sapiens_hsa043400.64038776
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63961891
94B cell receptor signaling pathway_Homo sapiens_hsa046620.63942735
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62937627
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62726887
97Toxoplasmosis_Homo sapiens_hsa051450.62647348
98Thyroid hormone synthesis_Homo sapiens_hsa049180.62157996
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61886107
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61610364
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61357645
102Non-small cell lung cancer_Homo sapiens_hsa052230.59847737
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.59611653
104MAPK signaling pathway_Homo sapiens_hsa040100.59570359
105Long-term depression_Homo sapiens_hsa047300.59516568
106TNF signaling pathway_Homo sapiens_hsa046680.59365175
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59249709
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58191333
109Graft-versus-host disease_Homo sapiens_hsa053320.57757328
110cAMP signaling pathway_Homo sapiens_hsa040240.57213345
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.56779978
112Retinol metabolism_Homo sapiens_hsa008300.56685254
113Chemical carcinogenesis_Homo sapiens_hsa052040.56058997
114Renin secretion_Homo sapiens_hsa049240.55982804
115Fatty acid elongation_Homo sapiens_hsa000620.55934443
116Chemokine signaling pathway_Homo sapiens_hsa040620.55256081
117Melanogenesis_Homo sapiens_hsa049160.54373918
118Circadian rhythm_Homo sapiens_hsa047100.54278874
119Glycerolipid metabolism_Homo sapiens_hsa005610.53922695
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52953167
121Bile secretion_Homo sapiens_hsa049760.52567240
122Wnt signaling pathway_Homo sapiens_hsa043100.52115853
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52005158
124Acute myeloid leukemia_Homo sapiens_hsa052210.51680098
125Protein digestion and absorption_Homo sapiens_hsa049740.51651478
126AMPK signaling pathway_Homo sapiens_hsa041520.51570937
127Oxytocin signaling pathway_Homo sapiens_hsa049210.51570216
128Cocaine addiction_Homo sapiens_hsa050300.51194028
129Salmonella infection_Homo sapiens_hsa051320.50574139
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50263618
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50246165
132Pathways in cancer_Homo sapiens_hsa052000.49785222
133mTOR signaling pathway_Homo sapiens_hsa041500.49782145
134Rheumatoid arthritis_Homo sapiens_hsa053230.49381989
135Ovarian steroidogenesis_Homo sapiens_hsa049130.48790874
136Butanoate metabolism_Homo sapiens_hsa006500.47879232
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46114484
138Cholinergic synapse_Homo sapiens_hsa047250.46030434
139MicroRNAs in cancer_Homo sapiens_hsa052060.44661921
140T cell receptor signaling pathway_Homo sapiens_hsa046600.43038150
141Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42955250
142Malaria_Homo sapiens_hsa051440.42864250

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »