UBE2D4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water-soluble vitamin biosynthetic process (GO:0042364)4.93125881
2protein complex biogenesis (GO:0070271)4.31661214
3behavioral response to nicotine (GO:0035095)4.07071084
4mitochondrial respiratory chain complex I assembly (GO:0032981)3.93854712
5NADH dehydrogenase complex assembly (GO:0010257)3.93854712
6mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.93854712
7respiratory chain complex IV assembly (GO:0008535)3.89474956
8mitochondrial respiratory chain complex assembly (GO:0033108)3.82294365
9cytochrome complex assembly (GO:0017004)3.72866191
10cellular ketone body metabolic process (GO:0046950)3.63951055
11regulation of glucokinase activity (GO:0033131)3.59918997
12regulation of hexokinase activity (GO:1903299)3.59918997
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.30980627
14ketone body metabolic process (GO:1902224)3.29009985
15membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.28604682
16inositol phosphate catabolic process (GO:0071545)3.17962754
17tryptophan catabolic process (GO:0006569)3.14019652
18indole-containing compound catabolic process (GO:0042436)3.14019652
19indolalkylamine catabolic process (GO:0046218)3.14019652
20kynurenine metabolic process (GO:0070189)3.12923126
21regulation of skeletal muscle contraction (GO:0014819)3.12602737
22response to pheromone (GO:0019236)3.08753249
23nitric oxide mediated signal transduction (GO:0007263)3.07198745
24detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.01743507
25preassembly of GPI anchor in ER membrane (GO:0016254)3.00514156
26platelet dense granule organization (GO:0060155)2.96695436
27neuronal action potential propagation (GO:0019227)2.96182211
28dopamine transport (GO:0015872)2.92004477
29negative regulation of cytosolic calcium ion concentration (GO:0051481)2.89518707
30regulation of neurotransmitter uptake (GO:0051580)2.88036694
31indolalkylamine metabolic process (GO:0006586)2.87915688
32axoneme assembly (GO:0035082)2.85598752
33detection of light stimulus involved in sensory perception (GO:0050962)2.83885195
34detection of light stimulus involved in visual perception (GO:0050908)2.83885195
35DNA deamination (GO:0045006)2.83313682
36auditory receptor cell stereocilium organization (GO:0060088)2.81250408
37xenobiotic catabolic process (GO:0042178)2.80603486
38ubiquinone biosynthetic process (GO:0006744)2.79784835
39synaptic transmission, cholinergic (GO:0007271)2.79522886
40positive regulation of meiosis (GO:0045836)2.77145491
41branched-chain amino acid catabolic process (GO:0009083)2.76863560
42phosphorylated carbohydrate dephosphorylation (GO:0046838)2.72041846
43inositol phosphate dephosphorylation (GO:0046855)2.72041846
44aromatic amino acid family catabolic process (GO:0009074)2.69553542
45regulation of relaxation of muscle (GO:1901077)2.68104090
46glycerophospholipid catabolic process (GO:0046475)2.67114766
47actin-myosin filament sliding (GO:0033275)2.62770870
48muscle filament sliding (GO:0030049)2.62770870
49regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.61445007
50C4-dicarboxylate transport (GO:0015740)2.61032729
51electron transport chain (GO:0022900)2.61010958
52L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.60673846
53respiratory electron transport chain (GO:0022904)2.58773259
54neuronal action potential (GO:0019228)2.58574597
55benzene-containing compound metabolic process (GO:0042537)2.58492992
56dentate gyrus development (GO:0021542)2.58159631
57proline transport (GO:0015824)2.57550047
58calcium ion import (GO:0070509)2.57355089
59protein polyglutamylation (GO:0018095)2.57236142
60ubiquinone metabolic process (GO:0006743)2.56077843
61alanine transport (GO:0032328)2.55669107
62mannosylation (GO:0097502)2.55277891
63tryptophan metabolic process (GO:0006568)2.55227484
64positive regulation of meiotic cell cycle (GO:0051446)2.53904067
65amine catabolic process (GO:0009310)2.52564702
66cellular biogenic amine catabolic process (GO:0042402)2.52564702
67piRNA metabolic process (GO:0034587)2.51150514
68positive regulation of mitochondrial fission (GO:0090141)2.47450956
69startle response (GO:0001964)2.47080294
70response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.45961667
71amino acid salvage (GO:0043102)2.45901754
72L-methionine salvage (GO:0071267)2.45901754
73L-methionine biosynthetic process (GO:0071265)2.45901754
74nonmotile primary cilium assembly (GO:0035058)2.45311640
75GPI anchor metabolic process (GO:0006505)2.44151760
76cullin deneddylation (GO:0010388)2.43678825
77polyol catabolic process (GO:0046174)2.41491904
78adenosine metabolic process (GO:0046085)2.41313460
79L-fucose catabolic process (GO:0042355)2.41189859
80fucose catabolic process (GO:0019317)2.41189859
81L-fucose metabolic process (GO:0042354)2.41189859
82gamma-aminobutyric acid transport (GO:0015812)2.39003238
83vitamin biosynthetic process (GO:0009110)2.37353302
84C-terminal protein amino acid modification (GO:0018410)2.37020433
85somite development (GO:0061053)2.36890642
86action potential (GO:0001508)2.36103682
87kidney morphogenesis (GO:0060993)2.35299978
88positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.34693271
89sulfation (GO:0051923)2.34401984
90indole-containing compound metabolic process (GO:0042430)2.33654211
91anterograde synaptic vesicle transport (GO:0048490)2.33132547
92aspartate family amino acid catabolic process (GO:0009068)2.30515064
93membrane depolarization during action potential (GO:0086010)2.30509381
94skeletal muscle contraction (GO:0003009)2.30103960
95regulation of sarcomere organization (GO:0060297)2.30055058
96S-adenosylmethionine metabolic process (GO:0046500)2.29755705
97protein localization to cilium (GO:0061512)2.29469494
98neuromuscular synaptic transmission (GO:0007274)2.29253692
99regulation of action potential (GO:0098900)2.28912978
100pyrimidine nucleobase catabolic process (GO:0006208)2.28803819

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.21154258
2ZNF274_21170338_ChIP-Seq_K562_Hela3.08431160
3VDR_22108803_ChIP-Seq_LS180_Human2.73657782
4EZH2_22144423_ChIP-Seq_EOC_Human2.72139315
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.70638867
6IGF1R_20145208_ChIP-Seq_DFB_Human2.56278981
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.52008378
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.49836908
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32864446
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21894658
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10727817
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08856119
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.04087269
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90771552
15CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79152288
16FUS_26573619_Chip-Seq_HEK293_Human1.74734682
17ER_23166858_ChIP-Seq_MCF-7_Human1.73228386
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73177423
19P300_19829295_ChIP-Seq_ESCs_Human1.72673921
20TAF15_26573619_Chip-Seq_HEK293_Human1.71590683
21EWS_26573619_Chip-Seq_HEK293_Human1.66749628
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66603260
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63086992
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62568396
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61144646
26SMAD4_21799915_ChIP-Seq_A2780_Human1.57752945
27CBP_20019798_ChIP-Seq_JUKART_Human1.55608494
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55608494
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53991881
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.51080598
31BCAT_22108803_ChIP-Seq_LS180_Human1.50808288
32TP53_22573176_ChIP-Seq_HFKS_Human1.50101463
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49415599
34AR_25329375_ChIP-Seq_VCAP_Human1.47748130
35SOX2_19829295_ChIP-Seq_ESCs_Human1.43319532
36NANOG_19829295_ChIP-Seq_ESCs_Human1.43319532
37KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.43050528
38EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.42941284
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42442802
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.42282971
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40646032
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39651453
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39258686
44STAT3_23295773_ChIP-Seq_U87_Human1.38764302
45TCF4_23295773_ChIP-Seq_U87_Human1.37970864
46REST_21632747_ChIP-Seq_MESCs_Mouse1.37789104
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36617329
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.36514806
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.36188141
50* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35535478
51KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33836952
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.32783842
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32679766
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31057594
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29541914
56HTT_18923047_ChIP-ChIP_STHdh_Human1.29175562
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27345955
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.25366376
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25195990
60SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23000788
61NCOR_22424771_ChIP-Seq_293T_Human1.22365308
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21121717
63CRX_20693478_ChIP-Seq_RETINA_Mouse1.19389580
64TCF4_22108803_ChIP-Seq_LS180_Human1.19377983
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.18930026
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18703796
67P53_22387025_ChIP-Seq_ESCs_Mouse1.16633662
68REST_18959480_ChIP-ChIP_MESCs_Mouse1.15032118
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.14480828
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14480828
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13820579
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13777641
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.13293024
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12418640
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.12193511
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11257684
77RNF2_27304074_Chip-Seq_NSC_Mouse1.09908458
78CDX2_22108803_ChIP-Seq_LS180_Human1.09338029
79RUNX2_22187159_ChIP-Seq_PCA_Human1.08222518
80AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07921186
81AR_20517297_ChIP-Seq_VCAP_Human1.07204562
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07111381
83CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06731288
84SMAD4_21741376_ChIP-Seq_EPCs_Human1.06687399
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05972155
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.05525334
87EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05401680
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04587311
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03458874
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02366570
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02273426
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01831536
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01146454
94EST1_17652178_ChIP-ChIP_JURKAT_Human1.01055165
95SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00793356
96GATA3_21878914_ChIP-Seq_MCF-7_Human1.00121418
97JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98996311
98PRDM14_20953172_ChIP-Seq_ESCs_Human0.98281915
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98153189
100NOTCH1_21737748_ChIP-Seq_TLL_Human0.98021361

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.73547879
2MP0003646_muscle_fatigue3.73490472
3MP0004145_abnormal_muscle_electrophysio3.34085261
4MP0003195_calcinosis3.27559754
5MP0005646_abnormal_pituitary_gland2.41953177
6MP0002876_abnormal_thyroid_physiology2.38463224
7MP0006072_abnormal_retinal_apoptosis2.25752431
8MP0005551_abnormal_eye_electrophysiolog2.18855657
9MP0008877_abnormal_DNA_methylation2.07329093
10MP0005645_abnormal_hypothalamus_physiol2.04680838
11MP0000372_irregular_coat_pigmentation1.94523814
12MP0003283_abnormal_digestive_organ1.92277919
13MP0008875_abnormal_xenobiotic_pharmacok1.91122657
14MP0009046_muscle_twitch1.89061425
15MP0009745_abnormal_behavioral_response1.83466146
16MP0002272_abnormal_nervous_system1.82304569
17MP0004215_abnormal_myocardial_fiber1.81350303
18MP0005253_abnormal_eye_physiology1.79343281
19MP0006036_abnormal_mitochondrial_physio1.79218049
20MP0004270_analgesia1.79049224
21MP0001984_abnormal_olfaction1.78670374
22MP0002638_abnormal_pupillary_reflex1.74171950
23MP0000749_muscle_degeneration1.74136891
24MP0001968_abnormal_touch/_nociception1.69826645
25MP0002102_abnormal_ear_morphology1.63183859
26MP0003787_abnormal_imprinting1.60650446
27MP0003880_abnormal_central_pattern1.60359422
28MP0004142_abnormal_muscle_tone1.53802027
29MP0001501_abnormal_sleep_pattern1.53285767
30MP0002909_abnormal_adrenal_gland1.49996709
31MP0006276_abnormal_autonomic_nervous1.46679488
32MP0002064_seizures1.43522426
33MP0004885_abnormal_endolymph1.43002605
34MP0003011_delayed_dark_adaptation1.41150349
35MP0000013_abnormal_adipose_tissue1.38744125
36MP0005379_endocrine/exocrine_gland_phen1.38046900
37MP0004036_abnormal_muscle_relaxation1.35625091
38MP0004043_abnormal_pH_regulation1.35021315
39MP0010386_abnormal_urinary_bladder1.30910575
40MP0001986_abnormal_taste_sensitivity1.29532484
41MP0002163_abnormal_gland_morphology1.28782215
42MP0001905_abnormal_dopamine_level1.28252693
43MP0008775_abnormal_heart_ventricle1.26784747
44MP0001485_abnormal_pinna_reflex1.26761641
45MP0001486_abnormal_startle_reflex1.26551065
46MP0002736_abnormal_nociception_after1.25989163
47MP0005332_abnormal_amino_acid1.25969415
48MP0002734_abnormal_mechanical_nocicepti1.25787516
49MP0004130_abnormal_muscle_cell1.24531945
50MP0008872_abnormal_physiological_respon1.18776189
51MP0009780_abnormal_chondrocyte_physiolo1.17969353
52MP0002938_white_spotting1.17812894
53MP0000631_abnormal_neuroendocrine_gland1.17751299
54MP0002572_abnormal_emotion/affect_behav1.17728741
55MP0005167_abnormal_blood-brain_barrier1.16942551
56MP0001970_abnormal_pain_threshold1.13659638
57MP0002229_neurodegeneration1.12362739
58MP0005620_abnormal_muscle_contractility1.11847226
59MP0002557_abnormal_social/conspecific_i1.11710449
60MP0003635_abnormal_synaptic_transmissio1.09533564
61MP0005084_abnormal_gallbladder_morpholo1.08419592
62MP0002160_abnormal_reproductive_system1.07723775
63MP0002106_abnormal_muscle_physiology1.06948298
64MP0003879_abnormal_hair_cell1.06514591
65MP0002234_abnormal_pharynx_morphology1.05617950
66MP0002733_abnormal_thermal_nociception1.04840553
67MP0002653_abnormal_ependyma_morphology1.04193790
68MP0005670_abnormal_white_adipose1.03267147
69MP0003137_abnormal_impulse_conducting1.02571511
70MP0005075_abnormal_melanosome_morpholog1.01974202
71MP0003122_maternal_imprinting1.00890085
72MP0004085_abnormal_heartbeat1.00527423
73MP0004084_abnormal_cardiac_muscle0.99709548
74MP0002693_abnormal_pancreas_physiology0.99528356
75MP0002067_abnormal_sensory_capabilities0.99144105
76MP0004924_abnormal_behavior0.98886727
77MP0005386_behavior/neurological_phenoty0.98886727
78MP0002735_abnormal_chemical_nociception0.98010624
79MP0000569_abnormal_digit_pigmentation0.97940753
80MP0000230_abnormal_systemic_arterial0.95995750
81MP0002063_abnormal_learning/memory/cond0.93424939
82MP0006292_abnormal_olfactory_placode0.92543995
83MP0001944_abnormal_pancreas_morphology0.91235763
84MP0002127_abnormal_cardiovascular_syste0.90915009
85MP0002138_abnormal_hepatobiliary_system0.90700338
86MP0005369_muscle_phenotype0.89712894
87MP0005389_reproductive_system_phenotype0.89500177
88MP0004133_heterotaxia0.88379648
89MP0001440_abnormal_grooming_behavior0.87489038
90MP0002332_abnormal_exercise_endurance0.86033649
91MP0010329_abnormal_lipoprotein_level0.85387995
92MP0002139_abnormal_hepatobiliary_system0.84982101
93MP0000751_myopathy0.84578452
94MP0003950_abnormal_plasma_membrane0.83899605
95MP0005174_abnormal_tail_pigmentation0.83626509
96MP0005423_abnormal_somatic_nervous0.82546539
97MP0002078_abnormal_glucose_homeostasis0.81139125
98MP0005266_abnormal_metabolism0.79015836
99MP0003252_abnormal_bile_duct0.78133544
100MP0003633_abnormal_nervous_system0.77875878

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.39775593
2Muscle fiber inclusion bodies (HP:0100299)3.39186370
3Hepatic necrosis (HP:0002605)3.32294619
4Nemaline bodies (HP:0003798)3.30428978
5Mitochondrial inheritance (HP:0001427)3.24568677
6Progressive macrocephaly (HP:0004481)3.24202903
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.20780260
8Hepatocellular necrosis (HP:0001404)3.18798080
9Pancreatic cysts (HP:0001737)3.18417984
10Muscle hypertrophy of the lower extremities (HP:0008968)3.12857574
11Molar tooth sign on MRI (HP:0002419)3.05189928
12Abnormality of midbrain morphology (HP:0002418)3.05189928
13Increased CSF lactate (HP:0002490)3.04319419
14Abnormal mitochondria in muscle tissue (HP:0008316)3.01392577
15Acute encephalopathy (HP:0006846)3.01106172
16Calf muscle hypertrophy (HP:0008981)3.00381287
17Ketoacidosis (HP:0001993)2.96757896
18Pancreatic fibrosis (HP:0100732)2.93953154
19True hermaphroditism (HP:0010459)2.85057519
20Abnormality of the renal cortex (HP:0011035)2.82785187
21Medial flaring of the eyebrow (HP:0010747)2.81982903
22Type 2 muscle fiber atrophy (HP:0003554)2.81802954
23Methylmalonic acidemia (HP:0002912)2.78688330
24Type II lissencephaly (HP:0007260)2.77537932
25Congenital stationary night blindness (HP:0007642)2.73900877
26Renal cortical cysts (HP:0000803)2.70935556
27Nephronophthisis (HP:0000090)2.69594588
28Ketosis (HP:0001946)2.60271255
29Hypomagnesemia (HP:0002917)2.53940717
30Hyperventilation (HP:0002883)2.50775682
31Congenital sensorineural hearing impairment (HP:0008527)2.46805845
32Abnormal rod and cone electroretinograms (HP:0008323)2.43185982
33Methylmalonic aciduria (HP:0012120)2.41788543
34Respiratory failure (HP:0002878)2.39832936
35Large for gestational age (HP:0001520)2.32243425
36Hemiparesis (HP:0001269)2.29986277
37Abnormality of the renal medulla (HP:0100957)2.29904474
38Hypothermia (HP:0002045)2.27163316
39Abolished electroretinogram (ERG) (HP:0000550)2.25115841
40Cerebral edema (HP:0002181)2.22674942
41Attenuation of retinal blood vessels (HP:0007843)2.20478945
42Agitation (HP:0000713)2.19179729
43Muscle fiber atrophy (HP:0100295)2.18745871
44Pendular nystagmus (HP:0012043)2.17100694
453-Methylglutaconic aciduria (HP:0003535)2.15935980
46Exercise-induced muscle cramps (HP:0003710)2.13648133
47Polydipsia (HP:0001959)2.12193873
48Abnormal drinking behavior (HP:0030082)2.12193873
49Gait imbalance (HP:0002141)2.11007576
50Lactic acidosis (HP:0003128)2.10646583
51Lipid accumulation in hepatocytes (HP:0006561)2.06641786
52Optic disc pallor (HP:0000543)2.04969391
53CNS demyelination (HP:0007305)2.03906526
54Bundle branch block (HP:0011710)2.03629633
55Polyuria (HP:0000103)2.01607346
56Hyperglycinuria (HP:0003108)2.01426398
57Congenital primary aphakia (HP:0007707)1.99052650
58Absent rod-and cone-mediated responses on ERG (HP:0007688)1.97053561
59Lethargy (HP:0001254)1.96074013
60Abnormality of the calf musculature (HP:0001430)1.95860004
61Hypoglycemic coma (HP:0001325)1.93886169
62Increased serum lactate (HP:0002151)1.93692746
63Gaze-evoked nystagmus (HP:0000640)1.92363719
64Tachypnea (HP:0002789)1.92138721
65Absent phalangeal crease (HP:0006109)1.91432662
66Abnormality of magnesium homeostasis (HP:0004921)1.90571747
67Syncope (HP:0001279)1.90385386
68Increased hepatocellular lipid droplets (HP:0006565)1.90177293
69Abnormality of vitamin B metabolism (HP:0004340)1.89887011
70Insulin-resistant diabetes mellitus (HP:0000831)1.89406351
71Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88962596
72Abnormality of alanine metabolism (HP:0010916)1.88962596
73Hyperalaninemia (HP:0003348)1.88962596
74Progressive cerebellar ataxia (HP:0002073)1.87472386
75Hyperglycinemia (HP:0002154)1.85388190
76Abnormal EKG (HP:0003115)1.83354348
77Progressive inability to walk (HP:0002505)1.82732379
78Retinal dysplasia (HP:0007973)1.82590267
79Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81560102
80Exercise-induced myalgia (HP:0003738)1.81055676
81Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80428775
82Dicarboxylic aciduria (HP:0003215)1.80428775
83Aplasia/Hypoplasia of the fovea (HP:0008060)1.79975309
84Hypoplasia of the fovea (HP:0007750)1.79975309
85Abnormality of glycine metabolism (HP:0010895)1.79782441
86Abnormality of serine family amino acid metabolism (HP:0010894)1.79782441
87Left ventricular hypertrophy (HP:0001712)1.78614949
88Abnormality of urine glucose concentration (HP:0011016)1.78524519
89Glycosuria (HP:0003076)1.78524519
90Late onset (HP:0003584)1.78029891
91Inability to walk (HP:0002540)1.77992685
92Progressive microcephaly (HP:0000253)1.76802069
93Fetal akinesia sequence (HP:0001989)1.76468405
94Generalized aminoaciduria (HP:0002909)1.75795469
95Broad-based gait (HP:0002136)1.75385113
96Decreased central vision (HP:0007663)1.73910411
97Abnormality of macular pigmentation (HP:0008002)1.73870448
98Aplasia/Hypoplasia of the tibia (HP:0005772)1.73621938
99Renal Fanconi syndrome (HP:0001994)1.73051287
100Oligomenorrhea (HP:0000876)1.72902870

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.53802340
2BMPR1B4.13585623
3OBSCN3.52128281
4PHKG23.28130866
5PHKG13.28130866
6PINK13.19166970
7MAP4K22.60136211
8WNK32.44047937
9TAOK32.41813076
10GRK12.30179596
11ADRBK22.24008019
12MAPK131.95420107
13NUAK11.77373102
14BCKDK1.68875302
15PLK21.52717631
16MARK11.50897995
17MUSK1.48562243
18MST41.44082919
19PAK31.42139631
20INSRR1.38476022
21NTRK31.36121651
22DAPK21.33395389
23OXSR11.33016816
24STK391.28967874
25MAP3K41.26345438
26LIMK11.26142138
27WNK41.19915126
28ZAK1.17902071
29MAPKAPK31.10873991
30VRK21.05468311
31CASK1.05375727
32IRAK11.03708352
33CSNK1G21.02815206
34ERBB30.99704039
35CSNK1G10.98102606
36TLK10.97523576
37FER0.97376190
38CSNK1G30.94720058
39PRKCE0.93719032
40FGFR20.91612711
41ACVR1B0.90525948
42MAP2K60.88048371
43DYRK20.83652994
44EIF2AK30.82390478
45PIK3CG0.81410204
46PDK20.81125574
47STK160.80367371
48CAMK2D0.79940767
49PTK2B0.78199701
50MAP2K70.76764529
51VRK10.74618175
52CAMK2A0.74222258
53TXK0.73950789
54PIK3CA0.73322911
55CSNK1A1L0.71706865
56PRKCG0.71690414
57MAPKAPK50.68956108
58PKN10.68399205
59ADRBK10.66391890
60STK38L0.65990118
61GRK70.61921777
62PRKCI0.61608911
63PRKACA0.61043565
64TIE10.58086867
65GRK50.55910847
66CAMK10.55605416
67TNIK0.52852563
68TRPM70.51417780
69IKBKB0.50400773
70MARK30.50291359
71TNK20.49715769
72CSNK1A10.48135340
73PRKAA10.46652208
74PRKG10.45183589
75CCNB10.44284643
76PRKCQ0.44110755
77AKT30.43424620
78NME10.43344838
79PAK60.42228653
80EPHA40.41545277
81PASK0.41482969
82CAMK2G0.41442934
83PRKAA20.41150527
84PRKD30.39956317
85MAP2K10.39805938
86DAPK10.39376240
87PLK30.39367024
88CSNK1D0.39261385
89PRKACB0.38496120
90STK110.37402721
91PRKD20.35735414
92PRKCA0.35074595
93TRIM280.34061532
94RPS6KA50.33028483
95GSK3A0.30788490
96ROCK10.30372246
97PRKACG0.29599976
98CAMK2B0.29423798
99TEC0.28402507
100EIF2AK10.27676896

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001902.88647552
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.78553026
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.42611326
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.41414577
5Butanoate metabolism_Homo sapiens_hsa006502.38356529
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37652595
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.36342726
8Parkinsons disease_Homo sapiens_hsa050122.19622072
9Propanoate metabolism_Homo sapiens_hsa006402.14801557
10Phototransduction_Homo sapiens_hsa047442.10352949
11Cardiac muscle contraction_Homo sapiens_hsa042602.00255043
12Tryptophan metabolism_Homo sapiens_hsa003801.97816580
13Protein export_Homo sapiens_hsa030601.84863545
14Fatty acid elongation_Homo sapiens_hsa000621.72742123
15Nicotine addiction_Homo sapiens_hsa050331.72435279
16Linoleic acid metabolism_Homo sapiens_hsa005911.67504144
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.64150738
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62726382
19Alzheimers disease_Homo sapiens_hsa050101.57942214
20Peroxisome_Homo sapiens_hsa041461.56158392
21Insulin secretion_Homo sapiens_hsa049111.50800658
22Nitrogen metabolism_Homo sapiens_hsa009101.45794426
23Sulfur metabolism_Homo sapiens_hsa009201.45635112
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42587260
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41231059
26RNA polymerase_Homo sapiens_hsa030201.40426737
27Caffeine metabolism_Homo sapiens_hsa002321.39229334
28Fatty acid degradation_Homo sapiens_hsa000711.38586122
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36699390
30Collecting duct acid secretion_Homo sapiens_hsa049661.33701143
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30911910
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29458533
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27770119
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27747397
35beta-Alanine metabolism_Homo sapiens_hsa004101.27402690
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27137061
37Huntingtons disease_Homo sapiens_hsa050161.26636925
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.23167934
39Proteasome_Homo sapiens_hsa030501.21900099
40Fatty acid metabolism_Homo sapiens_hsa012121.21353589
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16269775
42Chemical carcinogenesis_Homo sapiens_hsa052041.15330523
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12563758
44Regulation of autophagy_Homo sapiens_hsa041401.12198507
45Circadian rhythm_Homo sapiens_hsa047101.10032514
46Ether lipid metabolism_Homo sapiens_hsa005651.06761337
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.93291957
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93061065
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91380465
50Circadian entrainment_Homo sapiens_hsa047130.91220153
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89636309
52Retinol metabolism_Homo sapiens_hsa008300.87256138
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86880418
54Synaptic vesicle cycle_Homo sapiens_hsa047210.86359572
55Morphine addiction_Homo sapiens_hsa050320.86155743
56Basal transcription factors_Homo sapiens_hsa030220.84312857
57GABAergic synapse_Homo sapiens_hsa047270.83497083
58Pyruvate metabolism_Homo sapiens_hsa006200.82613256
59Olfactory transduction_Homo sapiens_hsa047400.82477339
60Vitamin B6 metabolism_Homo sapiens_hsa007500.80710303
61Salivary secretion_Homo sapiens_hsa049700.79648425
62Metabolic pathways_Homo sapiens_hsa011000.79428897
63Calcium signaling pathway_Homo sapiens_hsa040200.75900731
64Arachidonic acid metabolism_Homo sapiens_hsa005900.75656774
65Arginine and proline metabolism_Homo sapiens_hsa003300.75222641
66Taste transduction_Homo sapiens_hsa047420.74529302
67Glycerolipid metabolism_Homo sapiens_hsa005610.74224534
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73659015
69ABC transporters_Homo sapiens_hsa020100.73247467
70RNA degradation_Homo sapiens_hsa030180.73171361
71Selenocompound metabolism_Homo sapiens_hsa004500.71466925
72Purine metabolism_Homo sapiens_hsa002300.71130690
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70852735
74Homologous recombination_Homo sapiens_hsa034400.70529236
75Folate biosynthesis_Homo sapiens_hsa007900.70053181
76Serotonergic synapse_Homo sapiens_hsa047260.69357690
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66990120
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66457297
79Glutamatergic synapse_Homo sapiens_hsa047240.65101641
80Ovarian steroidogenesis_Homo sapiens_hsa049130.64492959
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63514767
82Histidine metabolism_Homo sapiens_hsa003400.63244556
83Fanconi anemia pathway_Homo sapiens_hsa034600.58660086
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56871916
85Amphetamine addiction_Homo sapiens_hsa050310.56602379
86Renin secretion_Homo sapiens_hsa049240.55337728
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54644582
88One carbon pool by folate_Homo sapiens_hsa006700.54605003
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54329044
90Tyrosine metabolism_Homo sapiens_hsa003500.53967160
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51938632
92Starch and sucrose metabolism_Homo sapiens_hsa005000.51847582
93Glutathione metabolism_Homo sapiens_hsa004800.49129662
94Oxytocin signaling pathway_Homo sapiens_hsa049210.48594559
95Dilated cardiomyopathy_Homo sapiens_hsa054140.48512309
96Pyrimidine metabolism_Homo sapiens_hsa002400.46142079
97Fat digestion and absorption_Homo sapiens_hsa049750.45066473
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44085252
99PPAR signaling pathway_Homo sapiens_hsa033200.42681787
100Dopaminergic synapse_Homo sapiens_hsa047280.42508771

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »