UBE2D2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)7.00026381
2viral transcription (GO:0019083)6.88113986
3translational termination (GO:0006415)6.63028359
4ribosomal small subunit assembly (GO:0000028)5.73817773
5translational elongation (GO:0006414)5.69282558
6deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.61556035
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.57630597
8protein targeting to ER (GO:0045047)5.49581658
9cotranslational protein targeting to membrane (GO:0006613)5.48993433
10nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.44483378
11viral life cycle (GO:0019058)5.42505613
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.28914138
13cellular protein complex disassembly (GO:0043624)5.28316902
14maturation of SSU-rRNA (GO:0030490)5.23906716
15protein localization to endoplasmic reticulum (GO:0070972)5.16593687
16protein complex disassembly (GO:0043241)4.81027119
17pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.77195262
18pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.70894073
19deoxyribose phosphate biosynthetic process (GO:0046385)4.67540254
202-deoxyribonucleotide biosynthetic process (GO:0009265)4.67540254
21translational initiation (GO:0006413)4.66876842
22ribosomal large subunit biogenesis (GO:0042273)4.64633405
23macromolecular complex disassembly (GO:0032984)4.59854861
24pyrimidine nucleotide catabolic process (GO:0006244)4.27352236
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.27301468
26energy coupled proton transport, down electrochemical gradient (GO:0015985)4.11105731
27ATP synthesis coupled proton transport (GO:0015986)4.11105731
28protein maturation by protein folding (GO:0022417)4.04351181
29deoxyribonucleotide biosynthetic process (GO:0009263)3.96139577
30protein targeting to membrane (GO:0006612)3.95259171
31chaperone-mediated protein transport (GO:0072321)3.88479622
32regulation of protein heterodimerization activity (GO:0043497)3.84772946
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.82948450
34translation (GO:0006412)3.77920128
35nuclear-transcribed mRNA catabolic process (GO:0000956)3.74906350
36ribonucleoprotein complex biogenesis (GO:0022613)3.71274533
37mRNA catabolic process (GO:0006402)3.55989512
38oxidative phosphorylation (GO:0006119)3.52741078
39positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.51385053
40protein neddylation (GO:0045116)3.51366607
41negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.39034759
42negative regulation of RNA splicing (GO:0033119)3.37593301
43RNA catabolic process (GO:0006401)3.35329825
44pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.31086334
45formation of translation preinitiation complex (GO:0001731)3.29533861
46deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.28336227
47Arp2/3 complex-mediated actin nucleation (GO:0034314)3.23121602
48chromatin remodeling at centromere (GO:0031055)3.22575761
49heterochromatin organization (GO:0070828)3.18052699
50peptidyl-arginine omega-N-methylation (GO:0035247)3.17380041
51CENP-A containing nucleosome assembly (GO:0034080)3.16826513
52respiratory electron transport chain (GO:0022904)3.16373663
53histone arginine methylation (GO:0034969)3.15230516
54positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling3.13127597
55regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 3.13127597
56regulation of mitochondrial translation (GO:0070129)3.11873388
57metallo-sulfur cluster assembly (GO:0031163)3.11662332
58iron-sulfur cluster assembly (GO:0016226)3.11662332
59negative regulation of DNA-templated transcription, elongation (GO:0032785)3.11271691
60negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.09016387
61cellular component biogenesis (GO:0044085)3.08020555
62establishment of integrated proviral latency (GO:0075713)3.07873125
63protein targeting to mitochondrion (GO:0006626)3.07328701
64nucleobase-containing small molecule interconversion (GO:0015949)3.06637417
652-deoxyribonucleotide metabolic process (GO:0009394)3.04972412
66electron transport chain (GO:0022900)3.04160649
67mitotic nuclear envelope reassembly (GO:0007084)3.02912838
68nuclear envelope reassembly (GO:0031468)3.02912838
69mitotic chromosome condensation (GO:0007076)3.01383289
70establishment of protein localization to mitochondrion (GO:0072655)3.01095600
71establishment of protein localization to membrane (GO:0090150)2.98874031
72deoxyribonucleotide catabolic process (GO:0009264)2.98246005
73establishment of mitochondrion localization (GO:0051654)2.95117474
74establishment of viral latency (GO:0019043)2.94298066
75pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.93922275
76regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.88895838
77deoxyribose phosphate catabolic process (GO:0046386)2.87946802
78establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.86904276
79mitochondrion transport along microtubule (GO:0047497)2.86904276
803-UTR-mediated mRNA stabilization (GO:0070935)2.86198775
81deoxyribose phosphate metabolic process (GO:0019692)2.84839194
82DNA unwinding involved in DNA replication (GO:0006268)2.83467346
83mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.83240446
84negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.81915426
85protein localization to mitochondrion (GO:0070585)2.80035542
86viral protein processing (GO:0019082)2.78928370
87protein targeting (GO:0006605)2.77950053
88guanosine-containing compound biosynthetic process (GO:1901070)2.77809496
89mitochondrial calcium ion transport (GO:0006851)2.74853041
90positive regulation of mitochondrion organization (GO:0010822)2.74312856
91UTP biosynthetic process (GO:0006228)2.69979245
92kinetochore organization (GO:0051383)2.67403250
93kinetochore assembly (GO:0051382)2.66857586
94UTP metabolic process (GO:0046051)2.65047388
95deoxyribonucleotide metabolic process (GO:0009262)2.64052626
96GTP biosynthetic process (GO:0006183)2.62575889
97sequestering of actin monomers (GO:0042989)2.61659527
98telomere maintenance via semi-conservative replication (GO:0032201)2.61171003
99DNA replication-independent nucleosome assembly (GO:0006336)2.60171641
100DNA replication-independent nucleosome organization (GO:0034724)2.60171641

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.51117344
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.86308676
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.85695351
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.72837557
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.48108163
6MYC_18358816_ChIP-ChIP_MESCs_Mouse2.78234098
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.67380361
8* XRN2_22483619_ChIP-Seq_HELA_Human2.65869055
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.64902537
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.60933114
11THAP11_20581084_ChIP-Seq_MESCs_Mouse2.52117956
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49445237
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.36361132
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.30022598
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.29877612
16* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18911095
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12746284
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.11915565
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.03683324
20MYC_22102868_ChIP-Seq_BL_Human1.99504706
21CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.98834768
22E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94527743
23TTF2_22483619_ChIP-Seq_HELA_Human1.94188081
24POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91582908
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.90968750
26DCP1A_22483619_ChIP-Seq_HELA_Human1.90128485
27CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.89806840
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89071096
29ZFX_18555785_ChIP-Seq_MESCs_Mouse1.88439252
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.83396585
31GABP_19822575_ChIP-Seq_HepG2_Human1.82260382
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81361216
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.80867337
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.78478291
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.78301236
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.75292925
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.73919198
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.68466480
39VDR_21846776_ChIP-Seq_THP-1_Human1.66986751
40KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.59200555
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.55288864
42CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.46033938
43FOXP3_21729870_ChIP-Seq_TREG_Human1.45171853
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44339419
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43450451
46CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.43416366
47VDR_23849224_ChIP-Seq_CD4+_Human1.42274309
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41850008
49BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.38247028
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35655785
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.34838371
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33656201
53* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33645966
54CIITA_25753668_ChIP-Seq_RAJI_Human1.31381848
55KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30769183
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29092838
57CTCF_18555785_ChIP-Seq_MESCs_Mouse1.26012854
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24114005
59MAF_26560356_Chip-Seq_TH2_Human1.23625262
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23366705
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23188480
62ZNF263_19887448_ChIP-Seq_K562_Human1.22845189
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21873336
64KDM5A_27292631_Chip-Seq_BREAST_Human1.21331022
65OCT4_18692474_ChIP-Seq_MEFs_Mouse1.21066816
66TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.19643499
67LXR_22292898_ChIP-Seq_THP-1_Human1.18732265
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17927033
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17540542
70* E2F1_21310950_ChIP-Seq_MCF-7_Human1.17104840
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16844580
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14505420
73* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14330731
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.14232979
75SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13975947
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13571946
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13404603
78* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13370056
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11136972
80HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10599873
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10351052
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07936903
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06301145
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05811259
85CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04546978
86* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03965632
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02578152
88UTX_26944678_Chip-Seq_JUKART_Human1.02374297
89MAF_26560356_Chip-Seq_TH1_Human1.02292093
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02057379
91* FOXP1_21924763_ChIP-Seq_HESCs_Human1.01653470
92SA1_27219007_Chip-Seq_ERYTHROID_Human1.00638308
93ERG_21242973_ChIP-ChIP_JURKAT_Human0.99956140
94SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.99907249
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99768532
96P68_20966046_ChIP-Seq_HELA_Human0.98047730
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97488715
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97191969
99* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95970400
100ELF1_20517297_ChIP-Seq_JURKAT_Human0.95742705

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.21955914
2MP0003693_abnormal_embryo_hatching3.68385089
3MP0002163_abnormal_gland_morphology3.15990734
4MP0004957_abnormal_blastocyst_morpholog3.07158191
5MP0008932_abnormal_embryonic_tissue2.62963221
6MP0002653_abnormal_ependyma_morphology2.40747874
7MP0006292_abnormal_olfactory_placode2.39073884
8MP0003077_abnormal_cell_cycle2.22834647
9MP0003111_abnormal_nucleus_morphology2.12238202
10MP0008789_abnormal_olfactory_epithelium2.08484334
11MP0003123_paternal_imprinting2.03935430
12MP0005394_taste/olfaction_phenotype2.00038162
13MP0005499_abnormal_olfactory_system2.00038162
14MP0003787_abnormal_imprinting1.97117748
15MP0001529_abnormal_vocalization1.96504154
16MP0010094_abnormal_chromosome_stability1.87751778
17MP0000490_abnormal_crypts_of1.72042966
18MP0004185_abnormal_adipocyte_glucose1.71530612
19MP0003315_abnormal_perineum_morphology1.70459788
20MP0003763_abnormal_thymus_physiology1.69705771
21MP0006036_abnormal_mitochondrial_physio1.59511935
22MP0002822_catalepsy1.55190308
23MP0008058_abnormal_DNA_repair1.52224096
24MP0000350_abnormal_cell_proliferation1.46101852
25MP0004858_abnormal_nervous_system1.43431226
26MP0000703_abnormal_thymus_morphology1.40007586
27MP0003880_abnormal_central_pattern1.37795517
28MP0009333_abnormal_splenocyte_physiolog1.36204532
29MP0008007_abnormal_cellular_replicative1.35637218
30MP0008260_abnormal_autophagy1.34834921
31MP0000750_abnormal_muscle_regeneration1.32635521
32MP0001188_hyperpigmentation1.30697637
33MP0000778_abnormal_nervous_system1.30008389
34MP0001727_abnormal_embryo_implantation1.25797250
35MP0005379_endocrine/exocrine_gland_phen1.24584478
36MP0002398_abnormal_bone_marrow1.23701020
37MP0001730_embryonic_growth_arrest1.23264466
38MP0005671_abnormal_response_to1.21876272
39MP0009278_abnormal_bone_marrow1.21363737
40MP0000049_abnormal_middle_ear1.21263763
41MP0006035_abnormal_mitochondrial_morpho1.20355476
42MP0000313_abnormal_cell_death1.17397833
43MP0004859_abnormal_synaptic_plasticity1.17085692
44MP0003186_abnormal_redox_activity1.16323171
45MP0001346_abnormal_lacrimal_gland1.15769015
46MP0001919_abnormal_reproductive_system1.14064438
47MP0005501_abnormal_skin_physiology1.13794611
48MP0002009_preneoplasia1.13052831
49MP0004811_abnormal_neuron_physiology1.03494276
50MP0010030_abnormal_orbit_morphology1.03114154
51MP0003221_abnormal_cardiomyocyte_apopto1.02726924
52MP0004233_abnormal_muscle_weight1.02595819
53MP0000685_abnormal_immune_system1.01596183
54MP0001293_anophthalmia1.01050074
55MP0009053_abnormal_anal_canal1.00873983
56MP0001905_abnormal_dopamine_level1.00792184
57MP0002722_abnormal_immune_system0.99089588
58MP0003567_abnormal_fetal_cardiomyocyte0.97522068
59MP0002249_abnormal_larynx_morphology0.95946342
60MP0006276_abnormal_autonomic_nervous0.95098551
61MP0000716_abnormal_immune_system0.92766986
62MP0000465_gastrointestinal_hemorrhage0.92566618
63MP0002080_prenatal_lethality0.92159013
64MP0005423_abnormal_somatic_nervous0.91810251
65MP0003861_abnormal_nervous_system0.91254752
66MP0004510_myositis0.90511029
67MP0000955_abnormal_spinal_cord0.90096126
68MP0005451_abnormal_body_composition0.89768099
69MP0003121_genomic_imprinting0.89666694
70MP0001697_abnormal_embryo_size0.89015769
71MP0002429_abnormal_blood_cell0.88910946
72MP0002420_abnormal_adaptive_immunity0.88157333
73MP0001819_abnormal_immune_cell0.87587330
74MP0000358_abnormal_cell_content/0.87009514
75MP0001348_abnormal_lacrimal_gland0.86565383
76MP0000689_abnormal_spleen_morphology0.86060025
77MP0002085_abnormal_embryonic_tissue0.85806418
78MP0005187_abnormal_penis_morphology0.84118668
79MP0005380_embryogenesis_phenotype0.83314554
80MP0001672_abnormal_embryogenesis/_devel0.83314554
81MP0000631_abnormal_neuroendocrine_gland0.82770719
82MP0001881_abnormal_mammary_gland0.81635812
83MP0000343_altered_response_to0.79384010
84MP0002092_abnormal_eye_morphology0.78470356
85MP0002152_abnormal_brain_morphology0.78174550
86MP0000681_abnormal_thyroid_gland0.74836801
87MP0005000_abnormal_immune_tolerance0.74805139
88MP0006072_abnormal_retinal_apoptosis0.73501025
89MP0003436_decreased_susceptibility_to0.73034514
90MP0002019_abnormal_tumor_incidence0.72334146
91MP0005623_abnormal_meninges_morphology0.71021979
92MP0001800_abnormal_humoral_immune0.70058615
93MP0003122_maternal_imprinting0.69434958
94MP0002723_abnormal_immune_serum0.69394919
95MP0002796_impaired_skin_barrier0.69259650
96* MP0002210_abnormal_sex_determination0.69066522
97MP0003385_abnormal_body_wall0.68116806
98MP0000759_abnormal_skeletal_muscle0.66924278
99MP0001340_abnormal_eyelid_morphology0.66383537
100MP0009384_cardiac_valve_regurgitation0.66297251

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.59719846
2Abnormality of cells of the erythroid lineage (HP:0012130)5.44333209
3Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.73501617
4Decreased activity of mitochondrial respiratory chain (HP:0008972)4.73501617
5Abnormal number of erythroid precursors (HP:0012131)4.71379914
6Increased intramyocellular lipid droplets (HP:0012240)4.21029836
7Macrocytic anemia (HP:0001972)4.04042407
8Increased muscle lipid content (HP:0009058)3.89364533
9Pallor (HP:0000980)3.67802443
10Aplasia/Hypoplasia of the sacrum (HP:0008517)3.55220615
11Abnormal mitochondria in muscle tissue (HP:0008316)3.48355189
12Myokymia (HP:0002411)3.39995278
13Cortical dysplasia (HP:0002539)3.20243031
14Increased hepatocellular lipid droplets (HP:0006565)3.19983460
15Acute necrotizing encephalopathy (HP:0006965)3.17889847
16Ragged-red muscle fibers (HP:0003200)3.14712113
17Lipid accumulation in hepatocytes (HP:0006561)3.13037775
18Increased serum pyruvate (HP:0003542)2.94811594
19Mitochondrial inheritance (HP:0001427)2.76945925
20Renal Fanconi syndrome (HP:0001994)2.65439026
21Abnormality of reticulocytes (HP:0004312)2.64346155
22Progressive muscle weakness (HP:0003323)2.62971143
23Exercise intolerance (HP:0003546)2.60900589
24Acute encephalopathy (HP:0006846)2.59956595
25Abnormality of glycolysis (HP:0004366)2.48596334
26Increased CSF lactate (HP:0002490)2.46541834
27Deep palmar crease (HP:0006191)2.43864986
283-Methylglutaconic aciduria (HP:0003535)2.42706075
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.33630883
30Hyperthyroidism (HP:0000836)2.31817515
31Muscle stiffness (HP:0003552)2.30117812
32Respiratory difficulties (HP:0002880)2.28856238
33Muscle fiber atrophy (HP:0100295)2.24587066
34Hepatocellular necrosis (HP:0001404)2.21513019
35Hypertensive crisis (HP:0100735)2.21397553
36Dysphonia (HP:0001618)2.20450080
37Achilles tendon contracture (HP:0001771)2.20004073
38Atrophy/Degeneration involving motor neurons (HP:0007373)2.18107102
39Broad distal phalanx of finger (HP:0009836)2.17832632
40Lactic acidosis (HP:0003128)2.15757186
41Increased serum lactate (HP:0002151)2.14533708
42Progressive macrocephaly (HP:0004481)2.12487510
43Aplastic anemia (HP:0001915)2.12063668
44Microretrognathia (HP:0000308)2.10944555
45Cerebral edema (HP:0002181)2.07191433
46Pancytopenia (HP:0001876)2.05295656
47Hypokinesia (HP:0002375)2.05070919
48Partial duplication of thumb phalanx (HP:0009944)2.03895705
49Agammaglobulinemia (HP:0004432)2.02824612
50Calcaneovalgus deformity (HP:0001848)1.99977840
51Shoulder girdle muscle weakness (HP:0003547)1.99974800
52Microvesicular hepatic steatosis (HP:0001414)1.99335072
53Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.97894214
54Duplication of thumb phalanx (HP:0009942)1.97718683
55Hepatic necrosis (HP:0002605)1.97240157
56IgM deficiency (HP:0002850)1.96969254
57Amyotrophic lateral sclerosis (HP:0007354)1.96621176
58Septo-optic dysplasia (HP:0100842)1.96117609
59Truncus arteriosus (HP:0001660)1.94945073
60Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91106104
61Progressive external ophthalmoplegia (HP:0000590)1.90769969
62Hypoplastic left heart (HP:0004383)1.87807362
63Split foot (HP:0001839)1.86092535
64Myoglobinuria (HP:0002913)1.85725387
65Rhabdomyolysis (HP:0003201)1.84012736
66Colon cancer (HP:0003003)1.83271699
67Failure to thrive in infancy (HP:0001531)1.83169371
68Gastrointestinal stroma tumor (HP:0100723)1.83002465
69Limb dystonia (HP:0002451)1.79995457
70Maternal diabetes (HP:0009800)1.79398773
71Abnormal neuron morphology (HP:0012757)1.79121636
72Abnormality of the motor neurons (HP:0002450)1.79121636
73Fasciculations (HP:0002380)1.78354820
74Hyperparathyroidism (HP:0000843)1.78300672
75Depressed nasal ridge (HP:0000457)1.77958106
76Athetosis (HP:0002305)1.75637967
77Deformed tarsal bones (HP:0008119)1.75501647
78Centrally nucleated skeletal muscle fibers (HP:0003687)1.75019111
79Hypercortisolism (HP:0001578)1.74943569
80Abnormality of the anterior horn cell (HP:0006802)1.74459205
81Degeneration of anterior horn cells (HP:0002398)1.74459205
82Retinal dysplasia (HP:0007973)1.73918007
83Insomnia (HP:0100785)1.73557736
84Myopathic facies (HP:0002058)1.71687353
85Growth hormone excess (HP:0000845)1.70915661
86Partial duplication of the phalanx of hand (HP:0009999)1.69790856
87Abnormality of the Achilles tendon (HP:0005109)1.69786762
88Myotonia (HP:0002486)1.69353257
89Absent thumb (HP:0009777)1.69352006
90Stenosis of the external auditory canal (HP:0000402)1.67830494
91Pelvic girdle muscle weakness (HP:0003749)1.67706134
92Thick lower lip vermilion (HP:0000179)1.67639835
93Gout (HP:0001997)1.64717532
94Abnormality of the hip-girdle musculature (HP:0001445)1.63754167
95Abnormality of the musculature of the pelvis (HP:0001469)1.63754167
96Abnormality of the tricuspid valve (HP:0001702)1.60180873
97Triphalangeal thumb (HP:0001199)1.59740269
98Exercise-induced muscle cramps (HP:0003710)1.57943605
99Multiple enchondromatosis (HP:0005701)1.56861537
100Horseshoe kidney (HP:0000085)1.56139336

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.35077120
2TESK24.12114384
3SCYL23.45152628
4ARAF3.44985884
5CDK192.71895391
6VRK22.66472874
7BUB12.52407593
8TESK12.49108652
9MAP3K112.43649325
10KDR2.25637106
11BCKDK2.20930834
12NEK12.15936966
13TAOK22.09731899
14LIMK12.04656713
15PIM21.92172121
16BRAF1.79250837
17CDC71.73580197
18MAP3K91.71905264
19DYRK21.58978137
20DYRK1B1.48793916
21STK161.47347596
22AURKA1.39772330
23DYRK31.36666988
24MAP3K131.34080987
25VRK11.32997515
26MAP3K101.31724307
27CDK141.27503268
28CSNK1G31.22589515
29CDK81.18521572
30CDK11A1.17366741
31MAP2K71.11022588
32MOS1.09805682
33DMPK1.09562551
34BCR1.07677434
35CDK151.07366241
36MAP4K11.05569077
37TAF11.03269366
38CDK181.03116071
39IRAK31.00576739
40SMG10.97988584
41CSNK1G20.96735633
42PRPF4B0.95370427
43PLK40.91570497
44PASK0.87304742
45ILK0.86469668
46GRK60.86463951
47CDK40.86085846
48EPHB20.81064426
49LRRK20.78913786
50UHMK10.77250993
51CSNK1A1L0.75329793
52PIM10.74667897
53AURKB0.73462718
54TYRO30.72612413
55MINK10.71250438
56TXK0.71219174
57RPS6KA40.71086285
58MAP2K20.70335312
59CHEK20.69853429
60MAP3K80.69046691
61ABL20.68675098
62CSNK1G10.68099680
63SIK30.67840843
64NEK20.67559290
65TBK10.66732418
66SRPK10.63870446
67TLK10.63699591
68IRAK40.63515144
69PLK10.62912473
70CDK70.60461480
71RPS6KB20.60317509
72SIK20.60041825
73MAP3K140.59433593
74MAP3K50.56410378
75DAPK30.55272005
76WEE10.54654975
77PAK10.50387516
78RPS6KA50.43370597
79BRSK10.42598163
80AKT20.42163365
81CSNK2A20.40996690
82CSNK2A10.40622443
83ICK0.40302805
84MAP3K40.39180295
85ATR0.38997123
86EIF2AK10.37994060
87CDK20.37525916
88RAF10.37505360
89RPS6KC10.36770713
90RPS6KL10.36770713
91MAP3K10.34946034
92FES0.34639785
93CDK30.31587735
94LATS20.31196981
95KSR20.30877957
96IRAK20.30300653
97TAOK30.30138876
98TRIB30.29705548
99TTK0.25626060
100KSR10.25357129

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.93619633
2Oxidative phosphorylation_Homo sapiens_hsa001903.38066457
3Parkinsons disease_Homo sapiens_hsa050123.30722433
4DNA replication_Homo sapiens_hsa030303.15356619
5Spliceosome_Homo sapiens_hsa030402.63933237
6Proteasome_Homo sapiens_hsa030502.44893533
7Mismatch repair_Homo sapiens_hsa034302.37915819
8Base excision repair_Homo sapiens_hsa034102.31891998
9Huntingtons disease_Homo sapiens_hsa050162.20035013
10Alzheimers disease_Homo sapiens_hsa050102.19266335
11Sulfur relay system_Homo sapiens_hsa041222.04260543
12Cardiac muscle contraction_Homo sapiens_hsa042602.02383453
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.94750106
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.91224220
15Pyrimidine metabolism_Homo sapiens_hsa002401.89136433
16RNA polymerase_Homo sapiens_hsa030201.67425299
17Primary immunodeficiency_Homo sapiens_hsa053401.63131986
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61724524
19Nucleotide excision repair_Homo sapiens_hsa034201.56033786
20Cell cycle_Homo sapiens_hsa041101.50493203
21mRNA surveillance pathway_Homo sapiens_hsa030151.41043751
22RNA transport_Homo sapiens_hsa030131.38942218
23Fanconi anemia pathway_Homo sapiens_hsa034601.33308786
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33087398
25Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.28914738
26Biosynthesis of amino acids_Homo sapiens_hsa012301.19698479
27* Shigellosis_Homo sapiens_hsa051311.19527102
28Folate biosynthesis_Homo sapiens_hsa007901.15102199
29Homologous recombination_Homo sapiens_hsa034401.13976747
30Epstein-Barr virus infection_Homo sapiens_hsa051691.10905893
31Basal transcription factors_Homo sapiens_hsa030221.07502625
32Protein export_Homo sapiens_hsa030601.07226798
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04603430
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03914041
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02813127
36Alcoholism_Homo sapiens_hsa050341.01749683
37Pentose phosphate pathway_Homo sapiens_hsa000301.00726168
38Notch signaling pathway_Homo sapiens_hsa043300.93217051
39Viral carcinogenesis_Homo sapiens_hsa052030.92841908
40Carbon metabolism_Homo sapiens_hsa012000.90134198
41* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89770825
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89655765
43RNA degradation_Homo sapiens_hsa030180.88530467
44Fatty acid elongation_Homo sapiens_hsa000620.84632302
45B cell receptor signaling pathway_Homo sapiens_hsa046620.84619043
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82228822
47Purine metabolism_Homo sapiens_hsa002300.82021609
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76201621
49Bladder cancer_Homo sapiens_hsa052190.75568886
50One carbon pool by folate_Homo sapiens_hsa006700.73322566
51Vibrio cholerae infection_Homo sapiens_hsa051100.73271683
52Thyroid cancer_Homo sapiens_hsa052160.72092270
53HTLV-I infection_Homo sapiens_hsa051660.70038886
54Oocyte meiosis_Homo sapiens_hsa041140.69682145
55Colorectal cancer_Homo sapiens_hsa052100.66731510
56T cell receptor signaling pathway_Homo sapiens_hsa046600.66483114
57Herpes simplex infection_Homo sapiens_hsa051680.65955938
58Salmonella infection_Homo sapiens_hsa051320.65795693
59p53 signaling pathway_Homo sapiens_hsa041150.65673229
60Systemic lupus erythematosus_Homo sapiens_hsa053220.63954688
61Synaptic vesicle cycle_Homo sapiens_hsa047210.62567382
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62037146
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.60801097
64VEGF signaling pathway_Homo sapiens_hsa043700.57936113
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57844036
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57814569
67* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56043954
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55395166
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55242946
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55207105
71Endocytosis_Homo sapiens_hsa041440.52203549
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50229444
73Pancreatic cancer_Homo sapiens_hsa052120.49764557
74Apoptosis_Homo sapiens_hsa042100.49680372
75Collecting duct acid secretion_Homo sapiens_hsa049660.49473267
76Viral myocarditis_Homo sapiens_hsa054160.47722000
77Non-small cell lung cancer_Homo sapiens_hsa052230.46342861
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46197877
79Chronic myeloid leukemia_Homo sapiens_hsa052200.44290080
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43370549
81Basal cell carcinoma_Homo sapiens_hsa052170.39733972
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39356983
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.38766135
84Acute myeloid leukemia_Homo sapiens_hsa052210.38750566
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.38058265
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36650144
87Prion diseases_Homo sapiens_hsa050200.36178396
88Hepatitis B_Homo sapiens_hsa051610.35679386
89Phenylalanine metabolism_Homo sapiens_hsa003600.34493431
90Galactose metabolism_Homo sapiens_hsa000520.33525763
91Wnt signaling pathway_Homo sapiens_hsa043100.32961046
92Axon guidance_Homo sapiens_hsa043600.32716093
93Pyruvate metabolism_Homo sapiens_hsa006200.28584144
94Measles_Homo sapiens_hsa051620.28336483
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27011467
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26310338
97Metabolic pathways_Homo sapiens_hsa011000.26232708
98Hippo signaling pathway_Homo sapiens_hsa043900.25916941
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25167235
100Renal cell carcinoma_Homo sapiens_hsa052110.24770885

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